251. Regression rate of clinical HPV infection of the lower genital tract during pregnancy after laser CO2 surgery.
- Author
-
Frega A, Baiocco E, Pace S, Palazzo A, Iacovelli R, Biamontil A, Moscarini M, and Stentella P
- Subjects
- Carbon Dioxide, Condylomata Acuminata virology, Female, Follow-Up Studies, Genital Diseases, Female virology, Humans, Postpartum Period, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Second, Recurrence, Retreatment statistics & numerical data, Condylomata Acuminata surgery, Genital Diseases, Female surgery, Laser Therapy, Pregnancy Complications, Infectious surgery
- Abstract
The objective of the study was to evaluate the effects of laser CO2 surgery during pregnancy to prevent clinical HPV infection recurrence after delivery and vertical infection. A case-control study was performed on 280 pregnant women affected by clinical HPV infection treated during pregnancy with 256 women treated three months after delivery. Follow-up was performed for a minimum of three colposcopic examinations for two years. Recurrence rates were calculated considering the number of positive findings for at least one colposcopic examination confirmed by biopsy after a negative control in a year. Statistical comparison of rates was performed by chi-squared and Fisher's exact test. Recurrence rates were higher in the women treated in postpartum (p < .01) than in the group treated during gestation (p < .005). Clinical HPV infections treated during the second trimester of pregnancy showed a sensitive decrease in recurrence-rate of infection. Rarity of respiratory papillomatosis makes conclusions inconsistent for the prevention of vertical infection.
- Published
- 2006