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This second updated volume on breast cancer provides a comprehensive overview of its clinical management and current therapies. Updated to reflect the changes in breast cancer staging, the progress in immunotherapy approaches, as well as the latest guidelines for therapies, this book brings readers up to speed with the latest therapeutic regimens in breast cancer and provides an in-depth account of current and new therapeutic approaches. The most important phase III trials, high quality meta-analysis, consensus reports and guidelines are extensively discussed in this new edition and provide the reader with the most up-to-date information.Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget'sdisease and phyllodes tumors and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must-have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.

Knapp 25 Jahre sind vergangen, seit die Eosinophile Ösophagitis (EoE) als eigenständiges Krankheitsbild erkannt worden ist. Heute belegen Fallberichte aus allen Kontinenten, dass die EoE weltweit zu einem relevanten Problem geworden ist und sowohl Patienten, Ärzte als auch Gesundheitssysteme erheblich belastet. Trotz intensiver Forschungstätigkeit mit mittlerweile über 300 wissenschaftlichen Publikationen pro Jahr sind wesentliche Fragen der Pathogenese und der Therapie auch heute noch nicht restlos geklärt. Trotzdem lohnt es sich, eine Zwischenbilanz zu ziehen. Dieses Buch hat das Ziel, die wesentlichen Eckpunkte der EoE in verständlicher Form zusammenzufassen, um Ärzte zu befähigen, ihre EoE-Patienten bestmöglich zu betreuen.

This book offers the reader sound advice on how to perform optimal conventional pediatric radiographs and how to obtain quick and easy organ dose estimates in order to improve the optimization process in pediatric imaging. Clear guidelines are provided for minimization of the radiation exposure of children through optimization of the radiation exposure conditions, and conversion coefficients are presented for calculation of the organ doses achieved in organs and tissues during conventional pediatric radiography, taking into consideration both optimal and suboptimal radiation field settings. Previously published conversion coefficients have failed to represent the variation in radiation field settings in daily clinical routine, which has made it difficult for the pediatric radiologist to estimate the impact of the field settings on absorbed doses in organs and tissues. The aim of this book, co-written by a pediatric radiologist, a physician and physicist, and a medical radiation technologist, is to address this issue by providing, for the first time, a thorough overview of clinical radiation field settings and their implications for radiation protection. An accompanying volume is devoted to fluoroscopy.

Dieses Frauenärztlichen Taschenbuch gibt eine Übersicht zur Diagnostik und Therapie von Myomen. Neben epidemiologischen Daten erfolgt die Darstellung wesentlicher diagnostischer Methoden mit Bildmaterial.Der Schwerpunkt des Buches liegt auf der medikamentösen Therapie von Myomen. Neben der kurzen Darstellung anderer Therapieverfahren werden einzelne medikamentöse Verfahren detailliert beschrieben. Ein besonderer Fokus wird auf die Langzeittherapie mit Progesteronmodulatoren gesetzt, dargestellt in typischen Kasuistiken. Zusammenfassend sind die Ergebnisse eines Expertenmeetings einschließlich eines Therapiealgorythmus dargelegt.

Das Standardwerk für die dreijährige Zusatzweiterbildung Kinder-Endokrinologie und –Diabetologie vereint zwei Subdisziplinen der Pädiatrie. Der Bogen spannt sich von den physiologischen Grundlagen bis hin zum speziellen Wissen über bestimmte Krankheitsentitäten und Untersuchungstechniken. Zudem werden Referenzwerttabellen für unterschiedliche Mess- und Laborwerte bereitgestellt.

This book focuses on the characteristic of glaucomatous optic neuropathy and its relationship with cerebrospinal fluid (CSF) pressure. It also explores the potential novel methods to manage glaucoma by adjusting CSF pressure. This book covers several interesting topics such as why normal tension glaucoma (NTG) patients still develops into glaucoma without high intraocular pressure (IOP); and whether there are factors other than IOP contributing to the pathogenesis of NTG why the role of IOP in the pathogenesis of POAG becomes vague and controversial. This book contains over 40 chapters, including numerous images from clinical patients and experiments on gross anatomy, pathological tissue, and immunohistochemistry, electronic speculum etc. The ophthalmologists and researchers can also benefit from the clinical cases. We hope this book serves as a clinical guidance with practical significant for the understanding, prevention and diagnosis of glaucoma.

Nearly 25 years have passed since eosinophilic esophagitis (EoE) has been recognized as an own, distinct entity. Initial doubts about the existence of this new disease were quickly eliminated by its dramatic increase. Despite intensive research activities with meanwhile more than 300 scientific publications per year, essential questions of pathogenesis and therapy are still unclear today. Nevertheless, it is worthwhile to draw up an interim balance. The purpose of this 2nd edition is to summarize the key parameters of EoE in an understandable way to empower clinicians to care for EoE patients.

This book provides an up-to-date review of the risk factors and genetics influencing the development of this rare disease. This volume presents clinical features and recent advances in histopathology and molecular profiling are analyzed, providing a valuable aid to clinicians in tailoring treatment to both the patient and the tumour. Readers will find important insights into the most effective strategies for making or negating a diagnosis of MBC. Within this timely volume, consideration is also given to the psychological needs of men with breast cancer alongside a discussion of the most effective support methods. The surgical management of the disease is examined, together with algorithms for local and systemic therapy. Owing to the problem of late diagnosis in MBC, many men have advanced or disseminated disease at diagnosis and, as such, the evidence-based management of these cases is reviewed. Male Breast Cancer concludes with a discussion on determiningprognosis and the likely future developments in MBC with a focus on improved diagnosis and survival. Male Breast Cancer will be of interest to breast surgeons, oncologists, breast radiologists, breast histopathologists and breast care nurses worldwide.

This second volume of the handbook on breast disease provides a comprehensive overview of its clinical management and current therapies. It brings readers up to speed with the latest guidelines and therapeutic regimens in breast cancer and provides and in-depth account of current and new therapeutic approaches. Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget's disease and phyllodes tumors, and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must- have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain aninterdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental, and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Neurochirurgie up to date Neurochirurgie – kaum ein anderes Fachgebiet stellt so hohe Anforderungen an Geschick und aktuelle Kenntnisse des behandelnden Facharztes. Die neuen Ansätze in der „Hightech-Medizin“ eröffnen effektive Möglichkeiten für Diagnostik und therapeutische Interventionen. Darüber hinaus ist aber auch eine interdisziplinäre Kooperation unabdingbar, um die bestmögliche Behandlung des Patienten zu gewährleisten. Die „Neurochirurgie“ von Moskopp und Wassmann bündelt die Fachexpertise von renommierten, erfahrenen Klinikern aus Neurochirurgie und angrenzenden Gebieten und Setzt mit der grundlegend aktualisierten und erweiterten 2. Auflage wieder Maßstäbe. - Das umfassende Lehr- und Referenzwerk für den gesamten deutschsprachigen Raum: Handbuch für die Aus- und Weiterbildung zum Facharzt für Neurochirurgie und interdiziplinäres Nachschlagewerk - Hochrangige Fachvertreter aus Neurochirurgie und angrenzenden Spezialgebieten: gesichertes und aktualisiertes Wissen von über 100 ausgewiesenen klinischen Experten - Neu in der 2. Auflage: - Berücksichtigung neuropädiatrischer Belange - Ausweitung spezieller zerebrovaskulärer und spinaler Aspekte - Zahlreiche neue Beiträge (u.a. Hirntumoren im Kindesalter, Glomustumoren, Thoracic-outlet-Syndrom, prächirurgische Epilepsiediagnostik, neurovaskuläre Dekompressionen bei Neuralgien) - Abstimmung auf die aktuelle WBO und Empfehlung zur Ausbildung zum Facharzt für Neurochirurgie - Refresher-Fragen zum Facharztwissen online KEYWORDS: Neuroanatomie, Hirntod, Koma, Neurodiagnostik, interdisziplinäre Neurochirurgie, funktionelle Neurochirurgie, pädiatrische und geriatrische Neurochirurgie, Schädel-Hirn-Traumata, intrakranielle und -spinale Blutungen, Gefäßmalformation, ZNS-Tumoren, ZNS-Infektionen, Erkrankungen im Bereich des Liquorsystems, Läsionen des kraniozervikalen Übergangs, Stenosen und Lähmungen, Myelopathien, radikuläre Syndrome, neurologisch-neurochirurgische Begutachtung, Facharztaus- und -weiterbildung, Facharztprüfung, Praxismanagement

Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest practices in dermatologic diagnosis and treatment at your fingertips. It delivers more comprehensive coverage of basic science, clinical practice, pediatric dermatology, and dermatologic surgery than you'll find in any other source. Whether you're a resident or an experienced practitioner, you'll have the in-depth, expert, up-to-the-minute answers you need to overcome any challenge you face in practice. Find answers fast with a highly user-friendly,'easy-in-easy-out'format and a wealth of tables and algorithms for instant visual comprehension. Get full exposure to core knowledge with coverage of dermatology's entire spectrum of subspecialties. See just the essential information with'need-to-know'basic science information and key references. Expedite decision making and clarify complex concepts with logical tables, digestible artwork, and easy-to-grasp schematics. Visualize more of the conditions you see in practice with over 3500 illustrations, of which over 1,400 are new: 1,039 clinical images, 398 pathology slides, and 152 schematics. Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color. Get an enhanced understanding of the foundations of dermatology in pathology, the clinical setting, and dermoscopy with a completely rewritten introductory chapter. Better comprehend the clinical-pathological relationship of skin disease with increased histologic coverage. Bolognia's Dermatology is the ultimate multimedia reference for residents in training AND the experienced practitioner.

This is a comprehensive, one-stop online book relating to all areas of pregnancy and birth. The second edition of this easily searchable guide is edited by eminent experts in the field and includes new contributions from international authors. It will be an ideal reference for Maternal-Fetal Specialists and Generalists wanting an authoritative answer on any point. Key features: •Grouped in to six topics (modules) for convenience•Electronic search facility across all chapters•Approximately 700,000 words of text, 7000 references, 300 figures (including 100 in full colour), and 200 tables available to search Key topics: •All common pregnancy and birth related problems such as diabetes and pregnancy•Many rarer complications such as protozoan infections•Fetal assessment, which is absolutely central to MFM practice•Medico-legal aspects•Sickle cell disease – a major problem for patients of African descent New chapters include: •Recurrent early pregnancy losses•Invasive hemodynamic monitoring•Chronic and acute hypertension•Neurological disorders•Maternal obesity•Assessment of fetal genetic disorders•First and second trimester screening

1897 wurde unter dem ersten Ordinarius für Kinderheilkunde der Medizinischen Fakultät Graz, Prof. Theodor Escherich, die erste Röntgeneinrichtung in einem Kinderkrankenhaus in Europa installiert. Bis in die 50er Jahre gehörte das Erlernen der gebräuchlichen Röntgenuntersuchungen zur Ausbildung eines Kinderarztes. 1963 wurde die European Society of Pediatric Radiology in Paris gegründet und auf dem Kinderärztekongress in Köln die Arbeitsgemeinschaft Pädiatrische Radiologie, aus der die Gesellschaft für Pädiatrische Radiologie der Kinderradiologen des gesamten deutschen Sprachraumes hervorging. Die Entwicklung von Sonographie und MRT beeinflusste die Kinderradiologie grundlegend. Ihr konsequenter Einsatz senkt die medizinisch verursachte Strahlenexposition bei Kindern und Jugendlichen weitestgehend.Dieses Buch gibt einen detaillierten Überblick über die Entwicklung und damit auch über die Bedeutung der Kinderradiologie in Deutschland, den Niederlanden, Österreich und der Schweiz.

O livro de dermatologia mais abrangente da atualidade com revisão científica da Sociedade Brasileira de Dermatologia. A 2ª Edição da obra Dermatologia, que já é referência no Brasil e no mundo, agraciada com o Highly Commended 2008 da British Medical Association, foi elaborada com ênfase na aprendizagem visual para ser usada semanal ou mesmo diário pelos dermatologistas, de forma que ofereça um fácil contato e a experiência necessária de fornecer informações atualizadas, tanto precisas quanto práticas.

For over 40 years Scheuer's Liver Biopsy Interpretation has been an invaluable resource for the pathologist in practice and in training in helping to solve diagnostic problems at the microscope. Lavishly illustrated in full color throughout it covers all aspects of liver pathology from the normal, the hepatidities, childhood disease and neoplasms. Copious technical tips and diagnostic'pearls'reflect the extensive experience and insight of the late Peter Scheuer and Jay Lefkowitch.. Throughout the text histopathologic features are correlated with clinical features to provide a practical account of how pathology impacts the diagnosis and management of liver disease.Well written, complete and concise quick reference.Helps the practicing and trainee pathologist solve diagnostic problems at the mircroscope.High quality color images complement the text throughout.Provides the user with a complete visual guide to each entity and assists in the recognition and diagnosis of any tissue sample under the microscope.Practical tips and “hands on” advice from two of the world's leading experts in liver pathology. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens.Glossary of frequently used terms and descriptions used in the pathology report contained at the end of the book. Useful quick reference for trainee pathologists and clinical hepatologists who may be unfamiliar with many of the terms and descriptions. Will assist in the writing and reading of a pathology report.A selection of a few general reading references at the end of each chapter.Directs the trainee or practitioner to the most relevant and authoritative sources of further information and study.A brand new chapter:'Practical Principles in Biopsy Assessment'. Focus is on interpretation rather than a mere listing of pathological changes. The initial overview of the biopsy specimen provides critical clues to diagnosis and a highly illustrated guide to ddx will be of enormous help in avoiding diagnostic errors.Expanded coverage throughout, especially of liver tumours, pediatric fatty liver disease, neonatal cholestasis. Keeps the user apprised of the key areas of growth and development in diagnosis and interpretation.Histopathology correlated with molecular genetics and immunohistochemistry whenever clinically relevant. Keeps the user up-to-date with all of the latest tools for performing a complete and accurate diagnosis.Many new high-quality colour illustrations. Helps the user identify a wide variety of pathologic lesions.Text and images available online via Expert Consult.

Being obese increases the risk of leukemia, non-Hodgkin lymphoma, multiple myeloma, breast, cervical, colorectal, esophageal, gallbladder, kidney, liver, ovarian, pancreatic, prostate, stomach, and uterine cancers. In addition, some studies show that obesity negatively affects a person's prognosis (chance of recovery). For example, obese men are more likely to be diagnosed with advanced prostate cancer, have a recurrence of prostate cancer, or die of prostate cancer than men who are not obese. This new volume presents significant recent research in the field from around the world.

Le «Traité de pneumologie» dont la 1ère édition a été publiée sous la direction du professeur Aubier en 1997, a immédiatement été reconnu comme le traité de référence dans la discipline. La nouvelle édition qui parait toujours sous la direction du professeur Aubier, prend en compte toutes les nouvelles acquisitions depuis 10 ans. L'ouvrage reste divisé en 4 parties : dans la 1ère, les auteurs traitent en 16 chapitres de la physiologie et la physiopathologie de l'appareil respiratoire, cette partie a été enrichie de chapitres sur le développement pulmonaire, l'immunologie respiratoire, le contrôle de la ventilation, l'altitude. Dans la 2ème partie, consacrée aux techniques d'exploration, les auteurs ont largement pris en compte les progrès de l'imagerie et en particulier de la tomodensitométrie et de la TEP. La 3ème partie traite des symptômes et syndromes : toux, dyspnée, expectoration, hémophysie, douleurs thoraciques. La 4ème partie expose, en 60 chapitres, toute la pathologie broncho-pulmonaire depuis la broncho-pneumopathie jusqu'aux manifestations respiratoires des maladies systémiques, en passant par l'asthme, le cancer broncho-pulmonaire, l'embolie pulmonaire, etc.. Dans cette édition, une place toute particulière a été réservée aux pneumopathies émergentes, aux localisations pulmonaires de l'infection par le VIH, à l'HTAP primitive, à la pollution. Dans tous ces chapitres de pathologie, les auteurs abordent successivement les signes cliniques, la stratégie diagnostique aidée des examens paracliniques, les armes thérapeutiques, les prévisions pronostiques. La richesse des illustrations, tableaux, arbres de décision, références bibliographiques fait de cet ouvrage complet, actuel et pratique l'outil indispensable au médecin.

Direct from the Cleveland Clinic Foundation, Endovascular Techniques in the Management of Cerebrovascular Disease is intended for neurologists, neurosurgery fellows-in training, and practicing clinicians with an interest in endovascular procedures. This essential volume:Reviews equipment, devices, and therapeutic agents such as anti-coagulants and

This definitive reference provides easy access to essential and authoritative clinical guidance on the full range of dermatologic entities encountered in today's practice. It delivers more comprehensive coverage of clinical adult and pediatric dermatology, drug therapy, dermatologic surgery, and pathology than you will find in any other single text. Thousands of helpful illustrations equip you with the visual guidance you need to arrive at confident diagnoses.Discusses pathologic entities in proportion to their incidence, enabling you to focus on the likeliest diagnoses for a given set of symptoms.Includes only the'need-to-know'basic science information and key references, so you have just the right amount of detail on every subject.Presents hundreds of full-color photographs depicting every type of skin disorder, along with a wealth of diagrams that clarify complex concepts and numerous algorithms that expedite decision making. Presents more'high-yield'information in restructured chapters, as well as expanded coverage of rarities - now displayed in table format - without increasing the extent of the book. Includes additional images covering more conditions, for enhanced reference power.

Ein Klassiker aktualisiert! Auch die 8. vollständig neu überarbeitete Auflage liefert unverzichtbares Basiswissen zur Beurteilung pflanzlicher Arzneimittel und beschreibt den Beitrag der Naturstoffforschung zur Entwicklung hochwirksamer Arzneistoffe. Berücksichtigt werden auch die aktuell gebräuchlichen Nahrungsergänzungsmittel und die in Europa verwendeten Arzneidrogen der traditionellen chinesischen Medizin. Die über sieben Auflagen bewährte Grundkonzeption wurde beibehalten: Das Werk informiert umfassend über die Bildung des Naturstoffs in der Pflanze bis zur Herstellung von pflanzlichen Arzneimitteln, deren chemisch-analytische Prüfung, pharmakologische Testung und therapeutische Anwendung. Es liefert Hintergrundwissen über Produkte, die in der Selbstmedikation tagtäglich von Hunderttausenden eingenommen werden. Der neue Hänsel/Sticher ist eine kompakte, aktuelle und wissenschaftlich-kritische Darstellung der Phytochemie, Phytopharmazie, Phytopharmakologie und Phytotherapie für Apotheker, Ärzte und Arzneimittelchemiker sowie ein praxisnahes Lehrbuch der Pharmazeutischen Biologie für Studierende der Pharmazie.