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Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mentalhealth and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.

This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

Nowadays, raw biological data can be easily stored as databases in computers but extracting the required information is the real challenge for researchers. For this reason, bioinformatics tools perform a vital role in extracting and analyzing information from databases. Bioinformatics Tools and Big Data Analytics for Patient describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery for patient care. The book gives details about the recent developments in the fields of artificial intelligence, cloud computing, and data analytics. It highlights the advances in computational techniques used to perform intelligent medical tasks. Features: Presents recent developments in the fields of artificial intelligence, cloud computing, and data analytics for improved patient care. Describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery. Summarizes several strategies, analyses, and optimization methods for patient healthcare. Focuses on drug discovery and development by cloud computing and data-driven research The targeted audience comprises academics, research scholars, healthcare professionals, hospital managers, pharmaceutical chemists, the biomedical industry, software engineers, and IT professionals.

Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations'role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. - Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine - Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks - Features contributions from leading voices in precision medicine and clinical decision support

Most human tissues do not regenerate spontaneously, but the development of biotherapies using stem cells may offer promising alternatives. Among the possible medium-term therapeutic applications for this technique are: cardiac insufficiency, preparation of small diameter arteries, treatment of atherosclerosis, bone repair, cartilage defects, burns, diabetes, liver or bladder regeneration, and neurodegenerative disorders. This concept of regenerative medicine is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering, and can be seen as a way of improving health and quality of life by restoring, maintaining, or enhancing tissue and organ function. This book presents the proceedings of the 9th China-France Symposium on Stem Cells and Regenerative Medicine, held in Strasbourg, France, from 2-4 October 2019.The aim of the symposium was to provide researchers, clinicians and students with a comprehensive, up-to-date overview of stem cells and potential medical applications in cellular and tissue engineering for the treatment of various chronic diseases. It also brought together scientists from various disciplines and experiences to discuss recent advances in the use and applications of stem cells. The contributions presented here divide into three main themes: cells; tissue engineering; and clinical applications. Important complementary aspects such as ethics and cell marketing are also discussed. Illustrating the challenges and recent progress achieved in the characterization of stem cells, the book will be of interest to all those working in the field.

Bridge the gap between ophthalmology and pathology with the 8th Edition of this comprehensive, easy-to-understand reference from Drs. Myron Yanoff and Joseph W. Sassani. Designed to keep you up to date with every aspect of the field, from current imaging techniques to genetics and molecular biology to clinical pearls, Ocular Pathology provides the concise yet complete information you need for board exams and clinical practice. - Includes new coverage of genetics and molecular biology, complications in diabetes mellitus, and the role of new drugs and other treatments for macular degeneration. - Covers the latest imaging techniques, including optical coherence tomography (OCT), anterior segment OCT (AS-OCT) and OCT-angiography. - Contains new images throughout that provide updated correlations between pathological and clinical aspects of each disorder. Clinicopathological correlations are presented with side-by-side image comparisons to make clinical pearl boxes even more useful. - Features more than 1,900 illustrations from the collections of internationally renowned leaders in ocular pathology. - Presents information in a quick-reference outline format – ideal for today's busy physician.

This monograph approaches from various angles the problematic difficulties of definition of multiple sclerosis. Although no figures or tables are included, a schematic series of attempts are made in terms of short review style the overall and specific highlights of pathologic involvement of the central nervous system in neurodegeneration,neuroinflammation and demyelination as seen in autopsy material. A clear concise style has been adopted that allows however the establishment of comprehensive inclusion of various pathogenic features of operative schematization of current understanding in MS pathogenesis. This volume is particularly suitable in view of the organic structuring of various operative factors in MS that interest students, post-graduates researchers of various disciplines, and also integrative information of interest to clinicians in active clinical investigations, and also pathologists and neuropathologists.

This 8 volume encyclopedia set presents important research on genetics. Some of the topics discussed herein include the speciation of Arabian gazelles, tau alternative splicing in Alzheimer's disease, Cornelia de Lange syndrome and autosomal dominant polycystic kidney disease.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With detailed coverage in contributions from over 250 of the world's most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. This volume, Foundations, summarizes basic theories, concepts, research areas, and the history of medical genetics, providing a contextual framework for integrating genetics into medical practice. In this new edition, clinically oriented information is supported by full-color images and expanded sections on the foundations of genetic analytics, next generation sequencing, and therapeutics. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. - Introduces genetic researchers, students, and health professionals to basic theories, concepts, research areas, and the history of medical genetics, offering a contextual framework for integrating genetics into medical practice - Completely revised and up-to-date, this new edition highlights traditional approaches and new developments in the field of medical genetics, including cancer genetics, genomic technologies, genome and exome sequencing, prenatal diagnosis, public health genetics, genetic counseling, and single-cell analysis for diagnosis - Includes color images supporting identification, concept illustration, and method processing - Features contributions by leading international researchers and practitioners of medical genetics

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With detailed coverage in contributions from over 250 of the world's most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly.Clinical Principles and Applications thoroughly addresses general methods and approaches to genetic counseling, genetic diagnostics, treatment pathways, and drug discovery. Additionally, new and updated chapters explore the clinical implementation of genomic technologies, analytics, and therapeutics, with special attention paid to developing technologies, common challenges, patient care, and ethical and legal aspects.With regular advances in genomic technologies propelling precision medicine into the clinic, the seventh edition of Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. - Fully revised and up-to-date, this new edition introduces genetic researchers, students, and health professionals to general principles of genetic counseling, genetic and genomic diagnostics, treatment pathways, drug discovery, and the application of genomic technologies, analytics, and therapeutics in clinical practice - Examines key topics and developing areas within clinical genomics, including genetic evaluation of patients, clinical trials and drug discovery, genetic health records, cytogenetic analysis, diagnostic molecular genetics, small molecule genetic therapeutics, gene product replacement, clinical teratology, transplantation genetics, and ethical and legal aspects of genomic medicine - Includes color images supporting identification, concept illustration, and method processing - Features contributions by leading international researchers and practitioners of medical genetics

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The ULTIMATE reference about syndromes to have on hand to facilitate rapid recognition and perioperative implications --- in full color Syndromes: Rapid Recognition and Perioperative Implications, Second Edition, is the ultimate reference for anesthesiologists, surgeons, internists, pediatricians, emergency physicians and nurses caring for patients affected with special operative needs and acute medical care. This updated book provides a complete A-to-Z encyclopedic clinical presentation of more than 2,200 syndromes. Extensive cross-referencing of international synonyms, classifications, and other conditions to be considered in the differential diagnosis further expands coverage to more than 5,000 entries. It is the most comprehensive reference on the subject. Syndromes: Rapid Recognition and Perioperative Implications, Second Edition, is enhanced by 200 high-quality photographs, in addition to tables, classifications and clinical management considerations. The addition of color tabs, a new feature, improve consultation and speed information retrieval. Each syndrome, listed in alphabetical order, is described as follows: •“At a glance” description•Synonyms•Incidence•Genetic Inheritance•Pathophysiology•Diagnosis•Clinical Aspects•Precautions Before Anesthesia•Anesthetic Considerations•Pharmacological Implications•Other conditions to be considered•References Health care providers, fellows and residents in training will find this textbook to be an essential reference to improve patient care in this highly demanding medical and surgical environment.

An Essential Guide to Cytogenetics explores the use of cytogenetic data for studies of frogs as well as the insights that hypotheses of phylogenetic relationships have added to this issue. The authors provide an overview of PcP190 satellite DNA, sex chromosome systems and B chromosomes found in Anura. This book also aim to establish the health effects of various activities and exposures by examining the levels of exposure and the biological effects resulting from the interaction between the organism and the chemical agent. Following this, a chapter is included which focuses on on the complex karyotype issues in myelodysplastic diseases, leukemias, lymphomas and multiple myelomas as the authors see them in daily practice in their center. The authors investigate hybridization, suggesting that the viability of a hybrid between species with a chromosomal discrepancy may offer important hypotheses to explain the morphological, molecular, and cytogenetic diversity of the genus. Trichorhinophalangeal syndrome is analyzed, suggesting that in cases of cytogenetically-invisible alterations, parental FISH analysis as well as aCGH should be considered as part of the clinical baseline testing.

This volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.

Even as classic cytogenetics has given way to molecular karyotyping, and as new deletion and duplication syndromes are identified almost every day, the fundamental role of the genetics clinic remains mostly unchanged. Genetic counselors and medical geneticists explain the'unexplainable,'helping families understand why abnormalities occur and whether they're likely to occur again. Chromosome Abnormalities and Genetic Counseling is the genetics professional's definitive guide to navigating both chromosome disorders and the clinical questions of the families they impact. Combining a primer on these disorders with the most current approach to their best clinical approaches, this classic text is more than just a reference; it is a guide to how to think about these disorders, even as our technical understanding of them continues to evolve. Completely updated and still infused with the warmth and voice that have made it essential reading for professionals across medical genetics, this edition of Chromosome Abnormalities and Genetic Counseling represents a leap forward in clinical understanding and communication. It is, as ever, essential reading for the field.

A popular and easy-to-use guide, this book is a must-have tool for clinical consultations in genetics and genomic medicine. Ideal for quick reference during practice, it covers the process of diagnosis, investigation, management, and counselling for patients. With a strong evidence base and international guidelines, it puts reliable and trustworthy guidance at your fingertips. Designed for use as a first-line guide, the A to Z format ensures it's accessible, and the simple layout makes it easy to assimilate information. Highly illustrated, the book also contains up-to-date glossaries of terms used in genetics and dysmorphology providing quick reference for key concepts. The second edition is an eagerly anticipated update of the gold standard in the specialty. It covers new developments in the field, particularly the advent of genome-wide sequencing and major updates in cancer. Fifteen new topics have been added, including Sudden cardiac death, Neonatal screening, and Ciliopathies. The authors have used their experience to devise a practical clinical approach to many common genetic referrals, both outpatient and ward based. The most common Mendelian disorders, chromosomal disorders, congenital anomalies and syndromes are all covered, and where available diagnostic criteria are included. In addition there are chapters on familial cancer and pregnancy-related topics such as fetal anomalies, teratogens, prenatal and pre-implantation diagnosis and non-invasive prenatal testing. The book also provides information on the less common situations where management is particularly complex. Both practical and pertinent, Oxford Desk Reference: Clinical Genetics and Genomics is the companion you need by your side during clinical consultations.

​​This book is the first of its kind to describe ocular manifestations of systemic diseases in the pediatric population. Written and edited by experts in areas of pediatric ophthalmology and genetics, this new text covers a multitude of topics in a comprehensive and cataloged fashion. The Eye in Pediatric Systemic Disease is designed as an in-depth and up-to-date reference work that is heavily referenced, thus allowing the reader ready access to the international supporting literature. Everything from ocular manifestations of hematologic disease, child abuse, psychiatric diseases, renal disorders, and vitamin disorders are covered, allowing readers to know what to look for in the eyes of children with a given systemic disorder. The Eye in Pediatric Systemic Disease is written in language that is accessible to ophthalmologists and pediatricians, as well as allied health care professionals.

Human Behavior Theory and Social Work Practice remains a foundation work for those interested in the practice and teaching of social work. Roberta Greene covers theoretical areas and individual theorists including classical psychoanalytic thought, Eriksonian theory, Carl Rogers, cognitive theory, systems theory, ecological perspectives, social construction, feminism, and genetics. She discusses the historical context, its philosophical roots, and major assumptions of each theory. The general theme, which distinguishes this volume, is that the person-in-environment perspective has been a central influence in the formation of the profession's knowledge base, as well as its approach to practice. Greene provides perspective on how individuals and social systems interact.This book examines how social workers can use theory to shape social work practice by increasing his or her understanding of and potential for enhancing human well-being. Greene covers the relationship between human behavior theory and professional social work practice. She also explores the challenges and limitations of each theory and addresses the following issues: how the theory serves as a framework for social work practice; how the theory lends itself to an understanding of individual, family, group, community, or organizational behavior; what the implications are of the theory for social work interventions or practice strategies; and what role it proposes for the social worker as a change agent.Throughout the profession's history, social workers have turned to a number of theoretical approaches for the organizing concepts needed to define their practice base. The aims of social work--to improve societal conditions and to enhance social functioning of and between individuals, families, and groups--are put into action across all fields of practice and realized through a variety of methods in a range of settings. This third edition, completely revised, represents a fundamental contribution to the field, and like its predecessors, will be widely used as a basic text.

Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the various areas, each chapter presents lessons for clinical management in an attempt to link basic research, physiology and pathophysiology with the clinical management of pubertal disorders. Puberty from Bench to Clinic bridges up-to-date concepts from animal and human physiology and pathology towards a better understanding and management of pubertal disorders, making it a unique resource for researchers in the field of development and reproduction, clinical scientists and practitioners in neuro-, pediatric and adolescent endocrinology as well as gynecology.

This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.

Ksiażka jest kontynuacją dwóch wydań Podstaw genetyki dla studentów i lekarzy. Jak dotychczas, jest to pierwszy podręcznik z tej dziedziny, który został napisany przez polskich autorów, zajmujących się na co dzień problemami genetyki i biologii medycznej. Podręcznik zawiera 35 rozdziałów, w których omówiono zagadnienia z podstaw genetyki klasycznej i medycznej. Poza omówieniem najważniejszych chorób genetycznych autorzy przedstawili, znane od dawna metody podstawowe oraz najnowsze techniki badań molekularnych i cytogenetycznych. W podręczniku znajdują się liczne tabele, ryciny i schematy oraz oryginalne fotografie. Na końcu każdego rozdziału umieszczono pytania kontrolne wraz z odpowiedziami. Pozycja adresowana jest przede wszystkim do studentów medycyny, biologii i biotechnologii. Podręcznik ten będzie również przydatny dla lekarzy w trakcie specjalizacji, a także dla tych już posiadających określoną specjalność medyczną. Kolejną, ważną grupą adresatów są praktykujący diagności laboratoryjni.

Human Behavior Theory and Social Work Practice remains a foundation work for those interested in the practice and teaching of social work. Roberta Greene covers theoretical areas and individual theorists including classical psychoanalytic thought, Eriksonian theory, Carl Rogers, cognitive theory, systems theory, ecological perspectives, social construction, feminism, and genetics. She discusses the historical context, its philosophical roots, and major assumptions of each theory. The general theme, which distinguishes this volume, is that the person-in-environment perspective has been a central influence in the formation of the profession's knowledge base, as well as its approach to practice. Greene provides perspective on how individuals and social systems interact. This book examines how social workers can use theory to shape social work practice by increasing his or her understanding of and potential for enhancing human well-being. Greene covers the relationship between human behavior theory and professional social work practice. She also explores the challenges and limitations of each theory and addresses the following issues: how the theory serves as a framework for social work practice; how the theory lends itself to an understanding of individual, family, group, community, or organizational behavior; what the implications are of the theory for social work interventions or practice strategies; and what role it proposes for the social worker as a change agent. Throughout the profession's history, social workers have turned to a number of theoretical approaches for the organizing concepts needed to define their practice base. The aims of social work--to improve societal conditions and to enhance social functioning of and between individuals, families, and groups--are put into action across all fields of practice and realized through a variety of methods in a range of settings. This third edition, completely revised, represents a fundamental contribution to the field, and like its predecessors, will be widely used as a basic text.

Title from PDF title page (viewed on Oct. 13, 2007).