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6,707 results on '"Otto, C"'

251. Supplementary Figure 2 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients

Author

I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Pierre G. Coulie, Gregor Winkels, Michelle van Rossum, Wim J.G. Oyen, Sandra Croockewit, Otto C. Boerman, Daniel Benitez-Ribas, Barbara M. Schulte, Gerty Schreibelt, Tetsuro Baba, Erik H.J.G. Aarntzen, and Jurjen Tel

Abstract

Supplementary Figure 2 PDF file - 46K, Supplementary Figure 2 Plasmacytoid DCs acquire CCL21-driven chemotactic ability upon activation

Published
2023
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252. Supplementary Figure 1 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients

Author

I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Pierre G. Coulie, Gregor Winkels, Michelle van Rossum, Wim J.G. Oyen, Sandra Croockewit, Otto C. Boerman, Daniel Benitez-Ribas, Barbara M. Schulte, Gerty Schreibelt, Tetsuro Baba, Erik H.J.G. Aarntzen, and Jurjen Tel

Abstract

Supplementary Figure 1 PDF file - 34K, Supplementary Figure 1 CliniMACS-based pDC isolation is feasible

Published
2023
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253. Supplementary Table 1 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients

Author

I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Pierre G. Coulie, Gregor Winkels, Michelle van Rossum, Wim J.G. Oyen, Sandra Croockewit, Otto C. Boerman, Daniel Benitez-Ribas, Barbara M. Schulte, Gerty Schreibelt, Tetsuro Baba, Erik H.J.G. Aarntzen, and Jurjen Tel

Abstract

Supplementary Table 1 PDF file - 29K, Induration (mm) of the different injection sites in the DTH skin test

Published
2023
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256. Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases

Author

Heskamp, Sandra, Heijmen, Linda, Gerrits, Danny, Molkenboer-Kuenen, Janneke D. M., ter Voert, Edwin G. W., Heinzmann, Kathrin, Honess, Davina J., Smith, Donna-Michelle, Griffiths, John R., Doblas, Sabrina, Sinkus, Ralph, Laverman, Peter, Oyen, Wim J. G., Heerschap, Arend, and Boerman, Otto C.

Published
2017
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261. Group Theoretical Approach to Pseudo-Hermitian Quantum Mechanics with Lorentz Covariance and c → ∞ Limit

Author

Suzana Bedić, Otto C. W. Kong, and Hock King Ting

Subjects
Lorentz covariant quantum mechanics, Minkowski Metric Operator, pseudo-unitary representation, pseudo-hermitian quantum mechanics, symmetry contraction limits, quantum nonrelativistic and classical limits, Mathematics, QA1-939
Abstract

We present the formulation of a version of Lorentz covariant quantum mechanics based on a group theoretical construction from a Heisenberg–Weyl symmetry with position and momentum operators transforming as Minkowski four-vectors. The basic representation is identified as a coherent state representation, essentially an irreducible component of the regular representation, with the matching representation of an extension of the group C*-algebra giving the algebra of observables. The key feature is that it is not unitary but pseudo-unitary, exactly in the same sense as the Minkowski spacetime representation. The language of pseudo-Hermitian quantum mechanics is adopted for a clear illustration of the aspect, with a metric operator obtained as really the manifestation of the Minkowski metric on the space of the state vectors. Explicit wavefunction description is given without any restriction of the variable domains, yet with a finite integral inner product. The associated covariant harmonic oscillator Fock state basis has all the standard properties in exact analog to those of a harmonic oscillator with Euclidean position and momentum operators. Galilean limit and the classical limit are retrieved rigorously through appropriate symmetry contractions of the algebra and its representation, including the dynamics described through the symmetry of the phase space.

Published
2020
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264. Conclusions

Author

Doering, Otto C., Randolph, J. C., Southworth, Jane, Pfeifer, Rebecca A., Doering, Otto C., III, editor, Randolph, J. C., editor, Southworth, Jane, editor, and Pfeifer, Rebecca A., editor

Published
2002
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265. Successful Combination of Sunitinib and Girentuximab in Two Renal Cell Carcinoma Animal Models: A Rationale for Combination Treatment of Patients with Advanced RCC

Author

Jeannette C. Oosterwijk-Wakka, Mirjam C.A. de Weijert, Gerben M. Franssen, William P.J. Leenders, Jeroen A.W.M. van der Laak, Otto C. Boerman, Peter F.A. Mulders, and Egbert Oosterwijk

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Anti-angiogenic treatment with tyrosine kinase inhibitors (TKI) has lead to an impressive increase in progression-free survival for patients with metastatic RCC (mRCC), but mRCC remains largely incurable. We combined sunitinib, targeting the endothelial cells with Girentuximab (monoclonal antibody cG250, recognizing carbonic anhydrase IX (CAIX) targeting the tumor cells to study the effect of sunitinib on the biodistribution of Girentuximab because combination of modalities targeting tumor vasculature and tumor cells might result in improved effect. Nude mice with human RCC xenografts (NU12, SK-RC-52) were treated orally with 0.8 mg/day sunitinib, or vehicle for 7 to 14 days. Three days before start or cessation of treatment mice were injected i.v. with 0.4 MBq/5 μg 111In-Girentuximab followed by biodistribution studies. Immunohistochemical analyses were performed to study the tumor vasculature and CAIX expression and to confirm Girentuximab uptake. NU12 appeared to represent a sunitinib sensitive tumor: sunitinib treatment resulted in extensive necrosis and decreased microvessel density (MVD). Accumulation of Girentuximab was significantly decreased when sunitinib treatment preceded the antibody injection but remained unchanged when sunitinib followed Girentuximab injection. Cessation of therapy led to a rapid neovascularization, reminiscent of a tumor flare. SK-RC-52 appeared to represent a sunitinib-resistant tumor: (central) tumor necrosis was minimal and MVD was not affected. Sunitinib treatment resulted in increased Girentuximab uptake, regardless of the sequence of treatment. These data indicate that sunitinib can be combined with Girentuximab. Since these two modalities have different modes of action, this combination might lead to enhanced therapeutic efficacy.

Published
2015
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268. Learning Dynamic 3D Geometry and Texture for Video Face Swapping

Author

Otto, C., primary, Naruniec, J., additional, Helminger, L., additional, Etterlin, T., additional, Mignone, G., additional, Chandran, P., additional, Zoss, G., additional, Schroers, C., additional, Gross, M., additional, Gotardo, P., additional, Bradley, D., additional, and Weber, R., additional

Published
2022
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282. Resistance Resurgent: Resurrecting a Method of Irregular Warfare in Great Power Competition

Author

Otto C. Fiala

Subjects
Great power, Competition (economics), Resistance (ecology), business.industry, Political science, Superpower, International trade, business, Irregular warfare
Abstract

The U.S. has spent the last two decades, during its short time as the singular superpower, engaging relatively successfully in counterterrorism. However, we have now entered a new era of Great Powe...

Published
2021
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284. A Persistent Simulation Environment for Autonomous Systems

Author

Kelley, Benjamin N, Williams, Ralph A, Holland, Jason L, Schnarr, Otto C, and Allen, B. Danette

Subjects
Cybernetics, Artificial Intelligence And Robotics
Abstract

The age of Autonomous Unmanned Aircraft Systems (AUAS) is creating new challenges for the accreditation and certification requiring new standards, policies and procedures that sanction whether a UAS is safe to fly. Establishing a basis for certification of autonomous systems via research into trust and trustworthiness is the focus of Autonomy Teaming and TRAjectories for Complex Trusted Operational Reliability (ATTRACTOR), a new NASA Convergent Aeronautics Solution (CAS) project. Simulation Environments to test and evaluate AUAS decision making may be a low-cost solution to help certify that various AUAS systems are trustworthy enough to be allowed to fly in current general and commercial aviation airspace. NASA is working to build a peer-to-peer persistent simulation (P3 Sim) environment. The P3 Sim will be a Massively Multiplayer Online (MMO) environment were AUAS avatars can interact with a complex dynamic environment and each other. The focus of the effort is to provide AUAS researchers a low-cost intuitive testing environment that will aid training for and assessment of decisions made by autonomous systems such as AUAS. This presentation focuses on the design approach and challenges faced in development of the P3 Sim Environment is support of investigating trustworthiness of autonomous systems.

Published
2018

285. Integration of Optical Coherence Tomography Scan Patterns to Augment Clinical Data Suite

Author

Mason, S, Patel, N, Van Baalen, M, Tarver, W, Otto, C, Samuels, B, Koslovsky, M, Schaefer, C, Taiym, W, Wear, M, and Tafreshi, A

Subjects
Aerospace Medicine
Abstract

Vision changes identified in long duration spaceflight astronauts has led Space Medicine at NASA to adopt a more comprehensive clinical monitoring protocol. Optical Coherence Tomography (OCT) was recently implemented at NASA, including on board the International Space Station in 2013. NASA is collaborating with Heidelberg Engineering to increase the fidelity of the current OCT data set by integrating the traditional circumpapillary OCT image with radial and horizontal block images at the optic nerve head. The retinal nerve fiber layer was segmented by two experienced individuals. Intra-rater (N=4 subjects and 70 images) and inter-rater (N=4 subjects and 221 images) agreement was performed. The results of this analysis and the potential benefits will be presented.

Published
2018

289. Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity

Author

Bol, Kalijn F., Aarntzen, Erik H. J. G., Pots, Jeanette M., Olde Nordkamp, Michel A. M., van de Rakt, Mandy W. M. M., Scharenborg, Nicole M., de Boer, Annemiek J., van Oorschot, Tom G. M., Croockewit, Sandra A. J., Blokx, Willeke A. M., Oyen, Wim J. G., Boerman, Otto C., Mus, Roel D. M., van Rossum, Michelle M., van der Graaf, Chantal A. A., Punt, Cornelis J. A., Adema, Gosse J., Figdor, Carl G., de Vries, I. Jolanda M., and Schreibelt, Gerty

Published
2016
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290. Lung Cancer in Austria

Author

Otto C. Burghuber, Walter Klepetko, Helmut Popper, Robert Pirker, Martin Filipits, Mir Alireza Hoda, Helmut Prosch, Sabine Zöchbauer-Müller, Karin Dieckmann, and Thomas Klikovits

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, business.industry, Smoking, MEDLINE, medicine.disease, Sex Factors, Text mining, Sex factors, Austria, Internal medicine, medicine, Humans, business, Lung cancer
Published
2021
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291. Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology

Author

Perkmann, Thomas, primary, Koller, Thomas, additional, Perkmann-Nagele, Nicole, additional, Ozsvar-Kozma, Maria, additional, Eyre, David, additional, Matthews, Philippa, additional, Bown, Abbie, additional, Stoesser, Nicole, additional, Breyer, Marie-Kathrin, additional, Breyer-Kohansal, Robab, additional, Burghuber, Otto C, additional, Hartl, Slyvia, additional, Aletaha, Daniel, additional, Sieghart, Daniela, additional, Quehenberger, Peter, additional, Marculescu, Rodrig, additional, Mucher, Patrick, additional, Radakovics, Astrid, additional, Klausberger, Miriam, additional, Duerkop, Mark, additional, Holzer, Barba, additional, Hartmann, Boris, additional, Strassl, Robert, additional, Leitner, Gerda, additional, Grebien, Florian, additional, Gerner, Wilhelm, additional, Grabherr, Reingard, additional, Wagner, Oswald F, additional, Binder, Christoph J, additional, and Haslacher, Helmuth, additional

Published
2022
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295. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study

Author

Roth, G, Mensah, G, Johnson, C, Addolorato, G, Ammirati, E, Baddour, L, Barengo, N, Beaton, A, Benjamin, E, Benziger, C, Bonny, A, Brauer, M, Brodmann, M, Cahill, T, Carapetis, J, Catapano, A, Chugh, S, Cooper, L, Coresh, J, Criqui, M, Decleene, N, Eagle, K, Emmons-Bell, S, Feigin, V, Fernandez-Sola, J, Fowkes, G, Gakidou, E, Grundy, S, He, F, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, H, Mirijello, A, Temesgen, A, Mokdad, A, Moran, A, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, A, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundstrom, J, Timpel, P, Tleyjeh, I, Valgimigli, M, Vos, T, Whelton, P, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Fowkes, F, Misganaw, A, Oliveira, G, Sliwa, K, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, W, Abu-Gharbieh, E, Abushouk, A, Acharya, D, Adair, T, Adebayo, O, Ademi, Z, Advani, S, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, M, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, C, Alahdab, F, Al-Eyadhy, A, Alhabib, K, Alif, S, Alipour, V, Aljunid, S, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, R, Amegah, A, Amini, S, Aminorroaya, A, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, C, Ansari-Moghaddam, A, Anteneh, Z, Antonazzo, I, Antony, B, Anwer, R, Appiah, L, Arabloo, J, Arnlov, J, Artanti, K, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, A, Awoke, M, Ayele, H, Ayza, M, Azari, S, B, D, Baheiraei, N, Baig, A, Bakhtiari, A, Banach, M, Banik, P, Baptista, E, Barboza, M, Barua, L, Basu, S, Bedi, N, Bejot, Y, Bennett, D, Bensenor, I, Berman, A, Bezabih, Y, Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, M, Boloor, A, Brant, L, Brenner, H, Briko, N, Butt, Z, Caetano dos Santos, F, Cahill, L, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cantu-Brito, C, Car, J, Carrero, J, Carvalho, F, Castaneda-Orjuela, C, Catala-Lopez, F, Cerin, E, Charan, J, Chattu, V, Chen, S, Chin, K, Choi, J, Chu, D, Chung, S, Cirillo, M, Coffey, S, Conti, S, Costa, V, Cundiff, D, Dadras, O, Dagnew, B, Dai, X, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Gongora, V, De la Hoz, F, De Neve, J, Denova-Gutierrez, E, Derbew Molla, M, Derseh, B, Desai, R, Deuschl, G, Dharmaratne, S, Dhimal, M, Dhungana, R, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, B, Duraes, A, Eagan, A, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, I, Elhadi, M, El-Jaafary, S, Esteghamati, S, Etisso, A, Eyawo, O, Fadhil, I, Faraon, E, Faris, P, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, M, Gaidhane, S, Ganji, M, Garg, J, Gebre, A, Gebregiorgis, B, Gebregzabiher, K, Gebremeskel, G, Getacher, L, Obsa, A, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, S, Gill, P, Gillum, R, Glushkova, E, Gnedovskaya, E, Golechha, M, Gonfa, K, Goudarzian, A, Goulart, A, Guadamuz, J, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, T, Hamadeh, R, Hamidi, S, Hankey, G, Hargono, A, Hartono, R, Hashemian, M, Hashi, A, Hassan, S, Hassen, H, Havmoeller, R, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, C, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Iqbal, U, Irvani, S, Islam, S, Islam, R, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, S, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, R, Jonas, J, Jonnagaddala, J, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, A, Katoto, P, Kayode, G, Khader, Y, Khammarnia, M, Khan, M, Khan, E, Khatab, K, Kibria, G, Kim, Y, Kim, G, Kimokoti, R, Kisa, S, Kisa, A, Kivimaki, M, Kolte, D, Koolivand, A, Korshunov, V, Koulmane Laxminarayana, S, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, G, Kumar, N, Kurmi, O, Kusuma, D, Kwan, G, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, Z, Lauriola, P, Lawrence, W, Laxmaiah, A, Legrand, K, Li, M, Li, B, Li, S, Lim, S, Lim, L, Lin, H, Lin, Z, Lin, R, Liu, X, Lopez, A, Lorkowski, S, Lotufo, P, Lugo, A, M, N, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, A, Mamun, A, Manafi, N, Mansournia, M, Mantovani, L, Martini, S, Mathur, M, Mazzaglia, G, Mehata, S, Mehndiratta, M, Meier, T, Menezes, R, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mirrakhimov, E, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, D, Mohammed, S, Mohammed, M, Mokhayeri, Y, Molokhia, M, Montasir, A, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velasquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, K, Nagarajan, A, Nalini, M, Nangia, V, Naqvi, A, Narasimha Swamy, S, Nascimento, B, Nayak, V, Nazari, J, Nazarzadeh, M, Negoi, R, Neupane Kandel, S, Nguyen, H, Nixon, M, Norrving, B, Noubiap, J, Nouthe, B, Nowak, C, Odukoya, O, Ogbo, F, Olagunju, A, Orru, H, Ortiz, A, Ostroff, S, Padubidri, J, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E, Parvizi, M, Pashazadeh Kan, F, Patel, U, Pathak, M, Paudel, R, Pepito, V, Perianayagam, A, Perico, N, Pham, H, Pilgrim, T, Piradov, M, Pishgar, F, Podder, V, Polibin, R, Pourshams, A, Pribadi, D, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, M, Rahman, M, Rahmani, A, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, S, Rathi, P, Rawal, L, Rawasia, W, Rawassizadeh, R, Remuzzi, G, Renzaho, A, Rezapour, A, Riahi, S, Roberts-Thomson, R, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, G, Saadatagah, S, Saber-Ayad, M, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, A, Santos, I, Santric-Milicevic, M, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, M, Schutte, A, Senthilkumaran, S, Sepanlou, S, Sha, F, Shahabi, S, Shahid, I, Shaikh, M, Shamali, M, Shamsizadeh, M, Shawon, M, Sheikh, A, Shigematsu, M, Shin, M, Shin, J, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, T, Silva, D, Singh, J, Mtech, A, Skryabin, V, Skryabina, A, Soheili, A, Spurlock, E, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, E, Tadesse, D, Tajdini, M, Tariqujjaman, M, Teklehaimanot, B, Temsah, M, Tesema, A, Thakur, B, Thankappan, K, Thapar, R, Thrift, A, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, M, Tripathi, A, Tripathy, J, Truelsen, T, Tsegay, G, Tsegaye, G, Tsilimparis, N, Tusa, B, Tyrovolas, S, Umapathi, K, Unim, B, Unnikrishnan, B, Usman, M, Vaduganathan, M, Valdez, P, Vasankari, T, Velazquez, D, Venketasubramanian, N, Vu, G, Vujcic, I, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, R, Weldemariam, A, Westerman, R, Winkler, A, Wiysonge, C, Wolfe, C, Wubishet, B, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, L, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, T, Yeshaw, Y, Yilgwan, C, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, S, Zaman, M, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, M, Zastrozhina, A, Zhang, Z, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, Y, Roth G. A., Mensah G. A., Johnson C. O., Addolorato G., Ammirati E., Baddour L. M., Barengo N. C., Beaton A. Z., Benjamin E. J., Benziger C. P., Bonny A., Brauer M., Brodmann M., Cahill T. J., Carapetis J., Catapano A. L., Chugh S. S., Cooper L. T., Coresh J., Criqui M., DeCleene N., Eagle K. A., Emmons-Bell S., Feigin V. L., Fernandez-Sola J., Fowkes G., Gakidou E., Grundy S. M., He F. J., Howard G., Hu F., Inker L., Karthikeyan G., Kassebaum N., Koroshetz W., Lavie C., Lloyd-Jones D., Lu H. S., Mirijello A., Temesgen A. M., Mokdad A., Moran A. E., Muntner P., Narula J., Neal B., Ntsekhe M., Moraes de Oliveira G., Otto C., Owolabi M., Pratt M., Rajagopalan S., Reitsma M., Ribeiro A. L. P., Rigotti N., Rodgers A., Sable C., Shakil S., Sliwa-Hahnle K., Stark B., Sundstrom J., Timpel P., Tleyjeh I. M., Valgimigli M., Vos T., Whelton P. K., Yacoub M., Zuhlke L., Murray C., Fuster V., Beaton A., Carapetis J. R., Chugh S., Criqui M. H., DeCleene N. K., Fowkes F. G. R., Kassebaum N. J., Koroshetz W. J., Misganaw A. T., Mokdad A. H., Oliveira G. M. M., Otto C. M., Owolabi M. O., Reitsma M. B., Rigotti N. A., Sable C. A., Shakil S. S., Sliwa K., Stark B. A., Tleyjeh I. I., Zuhlke L. J., Abbasi-Kangevari M., Abdi A., Abedi A., Aboyans V., Abrha W. A., Abu-Gharbieh E., Abushouk A. I., Acharya D., Adair T., Adebayo O. M., Ademi Z., Advani S. M., Afshari K., Afshin A., Agarwal G., Agasthi P., Ahmad S., Ahmadi S., Ahmed M. B., Aji B., Akalu Y., Akande-Sholabi W., Aklilu A., Akunna C. J., Alahdab F., Al-Eyadhy A., Alhabib K. F., Alif S. M., Alipour V., Aljunid S. M., Alla F., Almasi-Hashiani A., Almustanyir S., Al-Raddadi R. M., Amegah A. K., Amini S., Aminorroaya A., Amu H., Amugsi D. A., Ancuceanu R., Anderlini D., Andrei T., Andrei C. L., Ansari-Moghaddam A., Anteneh Z. A., Antonazzo I. C., Antony B., Anwer R., Appiah L. T., Arabloo J., Arnlov J., Artanti K. D., Ataro Z., Ausloos M., Avila-Burgos L., Awan A. T., Awoke M. A., Ayele H. T., Ayza M. A., Azari S., B D. B., Baheiraei N., Baig A. A., Bakhtiari A., Banach M., Banik P. C., Baptista E. A., Barboza M. A., Barua L., Basu S., Bedi N., Bejot Y., Bennett D. A., Bensenor I. M., Berman A. E., Bezabih Y. M., Bhagavathula A. S., Bhaskar S., Bhattacharyya K., Bijani A., Bikbov B., Birhanu M. M., Boloor A., Brant L. C., Brenner H., Briko N. I., Butt Z. A., Caetano dos Santos F. L., Cahill L. E., Cahuana-Hurtado L., Camera L. A., Campos-Nonato I. R., Cantu-Brito C., Car J., Carrero J. J., Carvalho F., Castaneda-Orjuela C. A., Catala-Lopez F., Cerin E., Charan J., Chattu V. K., Chen S., Chin K. L., Choi J. -Y. J., Chu D. -T., Chung S. -C., Cirillo M., Coffey S., Conti S., Costa V. M., Cundiff D. K., Dadras O., Dagnew B., Dai X., Damasceno A. A. M., Dandona L., Dandona R., Davletov K., De la Cruz-Gongora V., De la Hoz F. P., De Neve J. -W., Denova-Gutierrez E., Derbew Molla M., Derseh B. T., Desai R., Deuschl G., Dharmaratne S. D., Dhimal M., Dhungana R. R., Dianatinasab M., Diaz D., Djalalinia S., Dokova K., Douiri A., Duncan B. B., Duraes A. R., Eagan A. W., Ebtehaj S., Eftekhari A., Eftekharzadeh S., Ekholuenetale M., El Nahas N., Elgendy I. Y., Elhadi M., El-Jaafary S. I., Esteghamati S., Etisso A. E., Eyawo O., Fadhil I., Faraon E. J. A., Faris P. S., Farwati M., Farzadfar F., Fernandes E., Fernandez Prendes C., Ferrara P., Filip I., Fischer F., Flood D., Fukumoto T., Gad M. M., Gaidhane S., Ganji M., Garg J., Gebre A. K., Gebregiorgis B. G., Gebregzabiher K. Z., Gebremeskel G. G., Getacher L., Obsa A. G., Ghajar A., Ghashghaee A., Ghith N., Giampaoli S., Gilani S. A., Gill P. S., Gillum R. F., Glushkova E. V., Gnedovskaya E. V., Golechha M., Gonfa K. B., Goudarzian A. H., Goulart A. C., Guadamuz J. S., Guha A., Guo Y., Gupta R., Hachinski V., Hafezi-Nejad N., Haile T. G., Hamadeh R. R., Hamidi S., Hankey G. J., Hargono A., Hartono R. K., Hashemian M., Hashi A., Hassan S., Hassen H. Y., Havmoeller R. J., Hay S. I., Hayat K., Heidari G., Herteliu C., Holla R., Hosseini M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Huang J., Humayun A., Iavicoli I., Ibeneme C. U., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Iqbal U., Irvani S. S. N., Islam S. M. S., Islam R. M., Iso H., Iwagami M., Jain V., Javaheri T., Jayapal S. K., Jayaram S., Jayawardena R., Jeemon P., Jha R. P., Jonas J. B., Jonnagaddala J., Joukar F., Jozwiak J. J., Jurisson M., Kabir A., Kahlon T., Kalani R., Kalhor R., Kamath A., Kamel I., Kandel H., Kandel A., Karch A., Kasa A. S., Katoto P. D. M. C., Kayode G. A., Khader Y. S., Khammarnia M., Khan M. S., Khan M. N., Khan M., Khan E. A., Khatab K., Kibria G. M. A., Kim Y. J., Kim G. R., Kimokoti R. W., Kisa S., Kisa A., Kivimaki M., Kolte D., Koolivand A., Korshunov V. A., Koulmane Laxminarayana S. L., Koyanagi A., Krishan K., Krishnamoorthy V., Kuate Defo B., Kucuk Bicer B., Kulkarni V., Kumar G. A., Kumar N., Kurmi O. P., Kusuma D., Kwan G. F., La Vecchia C., Lacey B., Lallukka T., Lan Q., Lasrado S., Lassi Z. S., Lauriola P., Lawrence W. R., Laxmaiah A., LeGrand K. E., Li M. -C., Li B., Li S., Lim S. S., Lim L. -L., Lin H., Lin Z., Lin R. -T., Liu X., Lopez A. D., Lorkowski S., Lotufo P. A., Lugo A., M N. K., Madotto F., Mahmoudi M., Majeed A., Malekzadeh R., Malik A. A., Mamun A. A., Manafi N., Mansournia M. A., Mantovani L. G., Martini S., Mathur M. R., Mazzaglia G., Mehata S., Mehndiratta M. M., Meier T., Menezes R. G., Meretoja A., Mestrovic T., Miazgowski B., Miazgowski T., Michalek I. M., Miller T. R., Mirrakhimov E. M., Mirzaei H., Moazen B., Moghadaszadeh M., Mohammad Y., Mohammad D. K., Mohammed S., Mohammed M. A., Mokhayeri Y., Molokhia M., Montasir A. A., Moradi G., Moradzadeh R., Moraga P., Morawska L., Moreno Velasquez I., Morze J., Mubarik S., Muruet W., Musa K. I., Nagarajan A. J., Nalini M., Nangia V., Naqvi A. A., Narasimha Swamy S., Nascimento B. R., Nayak V. C., Nazari J., Nazarzadeh M., Negoi R. I., Neupane Kandel S., Nguyen H. L. T., Nixon M. R., Norrving B., Noubiap J. J., Nouthe B. E., Nowak C., Odukoya O. O., Ogbo F. A., Olagunju A. T., Orru H., Ortiz A., Ostroff S. M., Padubidri J. R., Palladino R., Pana A., Panda-Jonas S., Parekh U., Park E. -C., Parvizi M., Pashazadeh Kan F., Patel U. K., Pathak M., Paudel R., Pepito V. C. F., Perianayagam A., Perico N., Pham H. Q., Pilgrim T., Piradov M. A., Pishgar F., Podder V., Polibin R. V., Pourshams A., Pribadi D. R. A., Rabiee N., Rabiee M., Radfar A., Rafiei A., Rahim F., Rahimi-Movaghar V., Ur Rahman M. H., Rahman M. A., Rahmani A. M., Rakovac I., Ram P., Ramalingam S., Rana J., Ranasinghe P., Rao S. J., Rathi P., Rawal L., Rawasia W. F., Rawassizadeh R., Remuzzi G., Renzaho A. M. N., Rezapour A., Riahi S. M., Roberts-Thomson R. L., Roever L., Rohloff P., Romoli M., Roshandel G., Rwegerera G. M., Saadatagah S., Saber-Ayad M. M., Sabour S., Sacco S., Sadeghi M., Saeedi Moghaddam S., Safari S., Sahebkar A., Salehi S., Salimzadeh H., Samaei M., Samy A. M., Santos I. S., Santric-Milicevic M. M., Sarrafzadegan N., Sarveazad A., Sathish T., Sawhney M., Saylan M., Schmidt M. I., Schutte A. E., Senthilkumaran S., Sepanlou S. G., Sha F., Shahabi S., Shahid I., Shaikh M. A., Shamali M., Shamsizadeh M., Shawon M. S. R., Sheikh A., Shigematsu M., Shin M. -J., Shin J. I., Shiri R., Shiue I., Shuval K., Siabani S., Siddiqi T. J., Silva D. A. S., Singh J. A., Mtech A. S., Skryabin V. Y., Skryabina A. A., Soheili A., Spurlock E. E., Stockfelt L., Stortecky S., Stranges S., Suliankatchi Abdulkader R., Tadbiri H., Tadesse E. G., Tadesse D. B., Tajdini M., Tariqujjaman M., Teklehaimanot B. F., Temsah M. -H., Tesema A. K., Thakur B., Thankappan K. R., Thapar R., Thrift A. G., Timalsina B., Tonelli M., Touvier M., Tovani-Palone M. R., Tripathi A., Tripathy J. P., Truelsen T. C., Tsegay G. M., Tsegaye G. W., Tsilimparis N., Tusa B. S., Tyrovolas S., Umapathi K. K., Unim B., Unnikrishnan B., Usman M. S., Vaduganathan M., Valdez P. R., Vasankari T. J., Velazquez D. Z., Venketasubramanian N., Vu G. T., Vujcic I. S., Waheed Y., Wang Y., Wang F., Wei J., Weintraub R. G., Weldemariam A. H., Westerman R., Winkler A. S., Wiysonge C. S., Wolfe C. D. A., Wubishet B. L., Xu G., Yadollahpour A., Yamagishi K., Yan L. L., Yandrapalli S., Yano Y., Yatsuya H., Yeheyis T. Y., Yeshaw Y., Yilgwan C. S., Yonemoto N., Yu C., Yusefzadeh H., Zachariah G., Zaman S. B., Zaman M. S., Zamanian M., Zand R., Zandifar A., Zarghi A., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zhang Y., Zhang W., Zhong C., Zou Z., Zuniga Y. M. H., Murray C. J. 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O, Ademi, Z, Advani, S, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, M, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, C, Alahdab, F, Al-Eyadhy, A, Alhabib, K, Alif, S, Alipour, V, Aljunid, S, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, R, Amegah, A, Amini, S, Aminorroaya, A, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, C, Ansari-Moghaddam, A, Anteneh, Z, Antonazzo, I, Antony, B, Anwer, R, Appiah, L, Arabloo, J, Arnlov, J, Artanti, K, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, A, Awoke, M, Ayele, H, Ayza, M, Azari, S, B, D, Baheiraei, N, Baig, A, Bakhtiari, A, Banach, M, Banik, P, Baptista, E, Barboza, M, Barua, L, Basu, S, Bedi, N, Bejot, Y, Bennett, D, Bensenor, I, Berman, A, Bezabih, Y, Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, M, Boloor, A, Brant, L, Brenner, H, Briko, N, Butt, Z, Caetano dos Santos, F, Cahill, L, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cantu-Brito, C, Car, J, Carrero, J, Carvalho, F, Castaneda-Orjuela, C, Catala-Lopez, F, Cerin, E, Charan, J, Chattu, V, Chen, S, Chin, K, Choi, J, Chu, D, Chung, S, Cirillo, M, Coffey, S, Conti, S, Costa, V, Cundiff, D, Dadras, O, Dagnew, B, Dai, X, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Gongora, V, De la Hoz, F, De Neve, J, Denova-Gutierrez, E, Derbew Molla, M, Derseh, B, Desai, R, Deuschl, G, Dharmaratne, S, Dhimal, M, Dhungana, R, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, B, Duraes, A, Eagan, A, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, I, Elhadi, M, El-Jaafary, S, Esteghamati, S, Etisso, A, Eyawo, O, Fadhil, I, Faraon, E, Faris, P, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, M, Gaidhane, S, Ganji, M, Garg, J, Gebre, A, Gebregiorgis, B, Gebregzabiher, K, Gebremeskel, G, Getacher, L, Obsa, A, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, S, Gill, P, Gillum, R, Glushkova, E, Gnedovskaya, E, Golechha, M, Gonfa, K, Goudarzian, A, Goulart, A, Guadamuz, J, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, T, Hamadeh, R, Hamidi, S, Hankey, G, Hargono, A, Hartono, R, Hashemian, M, Hashi, A, Hassan, S, Hassen, H, Havmoeller, R, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, C, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Iqbal, U, Irvani, S, Islam, S, Islam, R, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, S, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, R, Jonas, J, Jonnagaddala, J, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, A, Katoto, P, Kayode, G, Khader, Y, Khammarnia, M, Khan, M, Khan, E, Khatab, K, Kibria, G, Kim, Y, Kim, G, Kimokoti, R, Kisa, S, Kisa, A, Kivimaki, M, Kolte, D, Koolivand, A, Korshunov, V, Koulmane Laxminarayana, S, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, G, Kumar, N, Kurmi, O, Kusuma, D, Kwan, G, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, Z, Lauriola, P, Lawrence, W, Laxmaiah, A, Legrand, K, Li, M, Li, B, Li, S, Lim, S, Lim, L, Lin, H, Lin, Z, Lin, R, Liu, X, Lopez, A, Lorkowski, S, Lotufo, P, Lugo, A, M, N, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, A, Mamun, A, Manafi, N, Mansournia, M, Mantovani, L, Martini, S, Mathur, M, Mazzaglia, G, Mehata, S, Mehndiratta, M, Meier, T, Menezes, R, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mirrakhimov, E, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, D, Mohammed, S, Mohammed, M, Mokhayeri, Y, Molokhia, M, Montasir, A, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velasquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, K, 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F., La Vecchia C., Lacey B., Lallukka T., Lan Q., Lasrado S., Lassi Z. S., Lauriola P., Lawrence W. R., Laxmaiah A., LeGrand K. E., Li M. -C., Li B., Li S., Lim S. S., Lim L. -L., Lin H., Lin Z., Lin R. -T., Liu X., Lopez A. D., Lorkowski S., Lotufo P. A., Lugo A., M N. K., Madotto F., Mahmoudi M., Majeed A., Malekzadeh R., Malik A. A., Mamun A. A., Manafi N., Mansournia M. A., Mantovani L. G., Martini S., Mathur M. R., Mazzaglia G., Mehata S., Mehndiratta M. M., Meier T., Menezes R. G., Meretoja A., Mestrovic T., Miazgowski B., Miazgowski T., Michalek I. M., Miller T. R., Mirrakhimov E. M., Mirzaei H., Moazen B., Moghadaszadeh M., Mohammad Y., Mohammad D. K., Mohammed S., Mohammed M. A., Mokhayeri Y., Molokhia M., Montasir A. A., Moradi G., Moradzadeh R., Moraga P., Morawska L., Moreno Velasquez I., Morze J., Mubarik S., Muruet W., Musa K. I., Nagarajan A. J., Nalini M., Nangia V., Naqvi A. A., Narasimha Swamy S., Nascimento B. R., Nayak V. C., Nazari J., Nazarzadeh M., Negoi R. 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W., Tsilimparis N., Tusa B. S., Tyrovolas S., Umapathi K. K., Unim B., Unnikrishnan B., Usman M. S., Vaduganathan M., Valdez P. R., Vasankari T. J., Velazquez D. Z., Venketasubramanian N., Vu G. T., Vujcic I. S., Waheed Y., Wang Y., Wang F., Wei J., Weintraub R. G., Weldemariam A. H., Westerman R., Winkler A. S., Wiysonge C. S., Wolfe C. D. A., Wubishet B. L., Xu G., Yadollahpour A., Yamagishi K., Yan L. L., Yandrapalli S., Yano Y., Yatsuya H., Yeheyis T. Y., Yeshaw Y., Yilgwan C. S., Yonemoto N., Yu C., Yusefzadeh H., Zachariah G., Zaman S. B., Zaman M. S., Zamanian M., Zand R., Zandifar A., Zarghi A., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zhang Y., Zhang W., Zhong C., Zou Z., Zuniga Y. M. H., and Murray C. J. L.

Abstract

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside

Published
2020

296. Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction-Results of the Chymase Inhibitor in Adverse Remodeling after Myocardial Infarction (CHIARA MIA) 2 tria

Author

Duengen, H, Kim, R, Zahger, D, Orvin, K, Kornowski, R, Admon, D, Kettner, J, Shimony, A, Otto, C, Becka, M, Kanefendt, F, Romo, A, Hasin, T, Ostadal, P, Rojas, G, Senni, M, GROUP investigators of the CHIARA MIA, 2, Duengen HD, Kim RJ, Zahger D, Orvin K, Kornowski R, Admon D, Kettner J, Shimony A, Otto C, Becka M, Kanefendt F, Romo AI, Hasin T, Ostadal P, Rojas GC, Senni M, GROUP investigators of the CHIARA MIA 2 trial, Duengen, H, Kim, R, Zahger, D, Orvin, K, Kornowski, R, Admon, D, Kettner, J, Shimony, A, Otto, C, Becka, M, Kanefendt, F, Romo, A, Hasin, T, Ostadal, P, Rojas, G, Senni, M, GROUP investigators of the CHIARA MIA, 2, Duengen HD, Kim RJ, Zahger D, Orvin K, Kornowski R, Admon D, Kettner J, Shimony A, Otto C, Becka M, Kanefendt F, Romo AI, Hasin T, Ostadal P, Rojas GC, Senni M, and GROUP investigators of the CHIARA MIA 2 trial

Abstract

Background: Adverse cardiac remodeling is a major risk factor for the development of post myocardial infarction (MI) heart failure (HF). This study investigates the effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute ST-segment-elevation myocardial infarction (STEMI). Methods: In this double-blind, randomized, placebo-controlled trial patients with first STEMI were eligible. To preferentially enrich patients at high risk of adverse remodeling, main inclusion criteria were a left-ventricular ejection fraction (LVEF) ≤45% and an infarct size >10% on day 5 to 9 post MI as measured by cardiac MRI. Patients were then randomized to 6 months treatment with either 25 mg fulacimstat (n = 54) or placebo (n = 53) twice daily on top of standard of care starting day 6 to 12 post MI. The changes in LVEF, LV end-diastolic volume index (LVEDVI), and LV end-systolic volume index (LVESVI) from baseline to 6 months were analyzed by a central blinded cardiac MRI core laboratory. Results: Fulacimstat was safe and well tolerated and achieved mean total trough concentrations that were approximately tenfold higher than those predicted to be required for minimal therapeutic activity. Comparable changes in LVEF (fulacimstat: 3.5% ± 5.4%, placebo: 4.0% ± 5.0%, P = .69), LVEDVI (fulacimstat: 7.3 ± 13.3 mL/m2, placebo: 5.1 ± 18.9 mL/m2, P = .54), and LVESVI (fulacimstat: 2.3 ± 11.2 mL/m2, placebo: 0.6 ± 14.8 mL/m2, P = .56) were observed in both treatment arms. Conclusion: Fulacimstat was safe and well tolerated in patients with left-ventricular dysfunction (LVD) after first STEMI but had no effect on cardiac remodeling.

Published
2020

299. CT airway remodelling and chronic cough

Author

Hazim Abozid, Miranda Kirby, Neha Nasir, Sylvia Hartl, Robab Breyer-Kohansal, Marie-Kathrin Breyer, Otto C Burghuber, Jean Bourbeau, Emiel F M Wouters, and Wan Tan

Subjects
Pulmonary and Respiratory Medicine, mechanisms, OUTCOMES, CT MRI etc, imaging, CHRONIC MUCUS HYPERSECRETION, ASSOCIATION, OBSTRUCTIVE PULMONARY-DISEASE, INFLAMMATION, cough, LUNG-FUNCTION DECLINE, YOUNG-ADULTS, FEV1 DECLINE, COHORT, pharmacology, VARIANT ASTHMA
Abstract

RationaleStructural airway changes related to chronic cough (CC) are described in the literature, but so far reported data are rare and non-conclusive. Furthermore, they derive mainly from cohorts with small sample sizes. Advanced CT imaging not only allows airway abnormalities to be quantified, but also to count the number of visible airways. The current study evaluates these airway abnormalities in CC and assesses the contribution of CC in addition to CT findings on the progression of airflow limitation, defined as a decline in forced expiratory volume in 1 s (FEV1) over time.MethodsA total of 1183 males and females aged ≥40 years with thoracic CT scans and valid spirometry from Canadian Obstructive Lung Disease, a Canadian multicentre, population-based study has been included in this analysis. Participants were stratified into 286 never-smokers, 297 ever-smokers with normal lung function and 600 with chronic obstructive pulmonary disease (COPD) of different severity grades. Imaging parameters analyses included total airway count (TAC), airway wall thickness, emphysema as well as parameters for functional small airway disease quantification.ResultsIrrespective of COPD presence, CC was not related to specific airway and lung structure features. Independent of TAC and emphysema score, CC was highly associated with FEV1 decline over time in the entire study population, particularly in ever-smokers (pConclusionThe absence of specific structural CT features independently from COPD presence indicate that other underlying mechanisms are contributing to the symptomatology of CC. On top of derived CT parameters, CC seems to be independently associated with FEV1 decline.Trial registration numberNCT00920348.

Published
2023
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