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893 results on '"Moulin, Pierre"'

254. Représentations sociales de la douleur

Author

Moulin, Pierre, Moulin, Pierre, Laboratoire de Psychologie Sociale - EHESS (LPS-EHESS), and École des hautes études en sciences sociales (EHESS)

Subjects
[SHS.PSY] Humanities and Social Sciences/Psychology, [SHS.ANTHRO-SE] Humanities and Social Sciences/Social Anthropology and ethnology, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, social representations, [SHS.PSY]Humanities and Social Sciences/Psychology, pain, douleur, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, représentations sociales, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1998

255. Social Imaginary and Cancer

Author

Moulin, Pierre, Santé reproductive, sexualité, infection à VIH - épidémiologie, démographie, sciences sociales, Institut national d'études démographiques (INED)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)-Institut national d'études démographiques (INED)

Subjects
Imaginary, Imaginaire Social, [SHS.SOCIO]Humanities and Social Sciences/Sociology, Common sense, Métaphores, [SHS.PSY]Humanities and Social Sciences/Psychology, Metaphors, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, Représentations sociales, Social representations, Sens commun, Cancer
Abstract

International audience; This paper aims at analyzing contemporary social imaginary about cancer, through the study of the main social (lay and erudite) representations linked to this pathology and which currently occur in France. More than a simple pathology among others, however, cancer generates a real “cultural universe” which reveals and questions the collective mentalities and practices, taking into account its epidemiological importance and at the same time its strong symbolic load and the increasing mobilisation of patients’associations. It is about these three aspects that we shall explain our comments.; Nous tenterons ici de décrypter l’imaginaire social contemporain du cancer en se fondant sur l’analyse des principales représentations sociales (profanes et savantes) de cette pathologie, qui ont cours actuellement en France. Mais plus qu’une pathologie, le cancer génère un authentique « univers culturel » qui vient révéler et questionner les mentalités et les conduites collectives, compte tenu à la fois de son importance épidémiologique, de sa forte charge symbolique et de la mobilisation croissante des associations de malades. C’est autour de ces trois aspects que nous développeronsnotre propos.

Published
2005

257. Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.

Author

Chapeau, Emilie A., Gembarska, Agnieszka, Durand, Eric Y., Mandon, Emeline, Estadieu, Claire, Romanet, Vincent, Wiesmann, Marion, Tiedt, Ralph, Lehar, Joseph, de Weck, Antoine, Rad, Roland, Barys, Louise, Jeay, Sebastien, Ferretti, Stephane, Kauffmann, Audrey, Sutter, Esther, Grevot, Armelle, Moulin, Pierre, Murakami, Masato, and Sellers, William R.

Subjects
MUTAGENESIS, LABORATORY mice, TRANSPOSONS, COHORT analysis, PHARMACOLOGY
Abstract

Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the TP53 gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent CDKN2A deletion in human cancer that, through inactivation of p14ARF, activates MDM2 protein, which in turn degrades TP53 tumor suppressor. Here we used piggyBac (PB) transposon insertional mutagenesis to anticipate resistance mechanisms occurring during treatment with the MDM2-TP53 inhibitor HDM201. Constitutive PB mutagenesis in Arf-/- mice provided a collection of spontaneous tumors with characterized insertional genetic landscapes. Tumors were allografted in large cohorts of mice to assess the pharmacologic effects of HDM201. Sixteen out of 21 allograft models were sensitive to HDM201 but ultimately relapsed under treatment. A comparison of tumors with acquired resistance to HDM201 and untreated tumors identified 87 genes that were differentially and significantly targeted by the PB transposon. Resistant tumors displayed a complex clonality pattern suggesting the emergence of several resistant subclones. Among the most frequent alterations conferring resistance, we observed somatic and insertional loss-of-function mutations in transformation-related protein 53 (Trp53) in 54% of tumors and transposonmediated gain-of-function alterations in B-cell lymphoma-extra large (Bcl-xL), Mdm4, and two TP53 family members, resulting in expression of the TP53 dominant negative truncations △NTrp63 and △NTrp73. Enhanced BCL-xL and MDM4 protein expression was confirmed in resistant tumors, as well as in HDM201-resistant patient-derived tumor xenografts. Interestingly, concomitant inhibition of MDM2 and BCL-xL demonstrated significant synergy in p53 wild-type cell lines in vitro. Collectively, our findings identify several potential mechanisms by which TP53 wild-type tumors may escape MDM2-targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2017
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258. Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats.

Author

Uteng, Marianne, Mahl, Andreas, Beckmann, Nicolau, Piaia, Alessandro, Ledieu, David, Dubost, Valerie, Tritto, Elaine, Wolf, Armin, Moulin, Pierre, Li Li, Chibout, Salah-Dine, and Pognan, Francois

Subjects
HEPATITIS B treatment, TENOFOVIR, LABORATORY rats, NEPHROTOXICOLOGY, MAGNETIC resonance imaging, GLOMERULAR filtration rate
Abstract

The aim of this study was to determine the relative safety of 4 antiviral drugs (telbivudine, tenofovir, adefovir, and entecavir) against hepatitis B virus with respect to kidney function and toxicity in male Sprague Dawley rats. The antiviral drugs were administered once daily for 4 weeks by oral gavage at ~10 and 25-40 times the human equivalent dose. Main assessments included markers of renal toxicity in urine, magnetic resonance imaging (MRI) of kidney function, histopathology, and electron microscopic examination. Administration of adefovir at 11 and 28 mg/kg for 4 weeks caused functional and morphological kidney alterations in a time- and dose-dependent manner, affecting mainly the proximal tubules and suggesting a mechanism of toxicity related to mitochondrial degeneration/depletion. Of note, the observed adefovir-induced reduction of kidney function was not detected by the standard method of glomerular filtration rate (GFR) measurements (clearance rate of the endogenous marker, creatinine), thereby emphasizing the superiority of MRI in terms of sensitive detection of GFR in rats. For the low dose of 300 mg/kg of tenofovir, minor kidney effects such as nuclear enlargement in the tubular epithelium, and hyaline droplets accumulation were detected, which was also observed for the low dose (11 mg/kg) of adefovir. No assessments could be done at the higher dose of 600/1000 mg/kg tenofovir due to gastrointestinal tract toxicity which prevented treatment of the animals for longer than 1 week. Entecavir at 1 and 3 mg/kg and telbivudine at 600 and 1600 mg/kg caused no toxicologically relevant effects on the kidney. [ABSTRACT FROM AUTHOR]

Published
2017
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260. Circulating microRNA biomarkers of paracetamol hepatotoxicity in zebrafish

Author

Vliegenthart, Bastiaan, primary, Lewis, Philip Starkey, additional, Tucker, Carl, additional, Del Pozo, Jorge, additional, Rider, Seb, additional, Antoine, Dan, additional, Dubost, Valerie, additional, Westphal, Magdalena, additional, Moulin, Pierre, additional, Bailey, Matthew, additional, Moggs, Jonathan, additional, Goldring, Chris, additional, Park, Kevin, additional, and Dear, James, additional

Published
2014
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266. Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity

Author

Vliegenthart, Adriaan D.B., primary, Starkey Lewis, Philip, additional, Tucker, Carl S., additional, Del Pozo, Jorge, additional, Rider, Sebastein, additional, Antoine, Daniel J., additional, Dubost, Valérie, additional, Westphal, Magdalena, additional, Moulin, Pierre, additional, Bailey, Matthew A., additional, Moggs, Jonathan G., additional, Goldring, Chris E., additional, Park, B. Kevin, additional, and Dear, James W., additional

Published
2014
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287. Sa1033 Interferon-Free Alisporivir Treatment Down-Regulates Interferon-Stimulated Genes Suggesting a Unique Antiviral Mechanism of Action for the Cyclophilin Inhibitor Alisporivir

Author

Kaiser, Sergio, primary, Gallay, Philippe, additional, Bobardt, Michael, additional, Bolognani, Federico, additional, Hartmann, Nicole, additional, Letzkus, Martin, additional, Rasul, Rashad, additional, Bao, Weibin, additional, Staedtler, Frank, additional, Johnson, Keith J., additional, Moulin, Pierre, additional, Avila, Claudio, additional, Naoumov, Nikolai V., additional, Nirmala, Nanguneri, additional, and Li, Bin, additional

Published
2013
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290. Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity

Author

Lia-Baldini, Anne-Sophie, primary, Magdelaine, Corinne, additional, Nizou, Angélique, additional, Airault, Coraline, additional, Salles, Jean-Pierre, additional, Moulin, Pierre, additional, Delemer, Brigitte, additional, Aitouares, Mina, additional, Funalot, Benoît, additional, Sturtz, Franck, additional, and Lienhardt-Roussie, Anne, additional

Published
2013
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291. Heart Structure-Specific Transcriptomic Atlas Reveals Conserved microRNA-mRNA Interactions

Author

Vacchi-Suzzi, Caterina, primary, Hahne, Florian, additional, Scheubel, Philippe, additional, Marcellin, Magali, additional, Dubost, Valerie, additional, Westphal, Magdalena, additional, Boeglen, Catherine, additional, Büchmann-Møller, Stine, additional, Cheung, Ming Sin, additional, Cordier, André, additional, De Benedetto, Christopher, additional, Deurinck, Mark, additional, Frei, Moritz, additional, Moulin, Pierre, additional, Oakeley, Edward, additional, Grenet, Olivier, additional, Grevot, Armelle, additional, Stull, Robert, additional, Theil, Diethilde, additional, Moggs, Jonathan G., additional, Marrer, Estelle, additional, and Couttet, Philippe, additional

Published
2013
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293. Predicting the Success of Volatility Targeting Strategies: Application to Equities and Other Asset Classes.

Author

PERCHET, ROMAIN, DE CARVALHO, RAUL LEOTE, HECKEL, THOMAS, and MOULIN, PIERRE

Subjects
GARCH model, ARCH model (Econometrics), MATHEMATICAL models of economic forecasting, SHARPE ratio, FINANCIAL ratios, PORTFOLIO management (Investments)
Abstract

The article investigates different Generalized Auto-Regressive Conditional Heteroskedasticity (GARCH) models with parameters reflecting empirical observations and specific features of volatility to establish a relationship between those parameters and the success of volatility targeting strategies in increasing the Sharpe ratio. It shows that the application of volatility targeting strategies for equities leads to an improvement in the Sharpe ratio and reduction in portfolio drawdowns.

Published
2016

294. Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion

Author

Lempiäinen, Harri, primary, Couttet, Philippe, additional, Bolognani, Federico, additional, Müller, Arne, additional, Dubost, Valérie, additional, Luisier, Raphaëlle, additional, del Rio-Espinola, Alberto, additional, Vitry, Veronique, additional, Unterberger, Elif B., additional, Thomson, John P., additional, Treindl, Fridolin, additional, Metzger, Ute, additional, Wrzodek, Clemens, additional, Hahne, Florian, additional, Zollinger, Tulipan, additional, Brasa, Sarah, additional, Kalteis, Magdalena, additional, Marcellin, Magali, additional, Giudicelli, Fanny, additional, Braeuning, Albert, additional, Morawiec, Laurent, additional, Zamurovic, Natasa, additional, Längle, Ulrich, additional, Scheer, Nico, additional, Schübeler, Dirk, additional, Goodman, Jay, additional, Chibout, Salah-Dine, additional, Marlowe, Jennifer, additional, Theil, Diethilde, additional, Heard, David J., additional, Grenet, Olivier, additional, Zell, Andreas, additional, Templin, Markus F., additional, Meehan, Richard R., additional, Wolf, Roland C., additional, Elcombe, Clifford R., additional, Schwarz, Michael, additional, Moulin, Pierre, additional, Terranova, Rémi, additional, and Moggs, Jonathan G., additional

Published
2012
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299. Investigative safety science as a competitive advantage for Pharma

Author

Moggs, Jonathan, primary, Moulin, Pierre, additional, Pognan, Francois, additional, Brees, Dominique, additional, Leonard, Michele, additional, Busch, Steve, additional, Cordier, Andre, additional, Heard, David J, additional, Kammüller, Michael, additional, Merz, Michael, additional, Bouchard, Page, additional, and Chibout, Salah-Dine, additional

Published
2012
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