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801 results on '"McBride, William H"'

261. Radiation and Inflammation.

Author

Schaue, Dörthe, Micewicz, Ewa D., Ratikan, Josephine A., Xie, Michael W., Genhong Cheng, and McBride, William H.

Abstract

The immune system has the power to modulate the expression of radiation-induced normal and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the other hand, it can influence acute and late radiation side effects, which in many ways resemble acute and chronic inflammatory disease states. The way radiation-induced inflammation feeds into adaptive antigen-specific immune responses adds another dimension to the tumor-host cross talk during radiation therapy and to possible radiation-driven autoimmune responses. Understanding how radiation affects inflammation and immunity is therefore critical if we are to effectively manipulate these forces for benefit in radiation oncology treatments. [ABSTRACT FROM AUTHOR]

Published
2015
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262. Radiation Biology in the Context of Changing Patterns of Radiotherapy.

Author

Murray, David, McBride, William H., and Schwartz, Jeffrey L.

Subjects
RADIOTHERAPY, PHYSIOLOGICAL effects of radiation, BRAIN tumors, RADIOBIOLOGY research, MEDICAL radiology
Abstract

The last decade has witnessed a revolution in the clinical application of high-dose 'ablative' radiation therapy. Initially this approach was limited to the treatment of brain tumors, but more recently we have seen its successful extension to tumors outside the brain, e.g., for small lung nodules. These advances have been driven largely by improvements in image-guided inverse treatment planning that allow the dose per fraction to the tumor to be increased over the conventional 2 Gy dose while keeping the late normal tissue complications at an acceptable level by dose limitation. Despite initial concerns about excessive late complications, as might be expected based on dose extrapolations using the linear-quadratic equation, these approaches have shown considerable clinical promise. Our knowledge of the biological consequences of high-doses of ionizing radiation in normal and cancerous tissues has lagged behind these clinical advances. Our intent here is to survey recent experimental findings from the perspective of better understanding the biological effects of high-dose therapy and whether they are truly different from conventional doses. We will also consider the implications of this knowledge for further refining and improving these approaches on the basis of underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2014
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266. Generation of Melanoma-Specific Cytotoxic T Lymphocytes by Dendritic Cells Transduced with a MART-1 Adenovirus

Author

Butterfield, Lisa H., primary, Jilani, Syed M., additional, Chakraborty, Nitya G., additional, Bui, Lynne A., additional, Ribas, Antoni, additional, Dissette, Vivian Beck, additional, Lau, Roy, additional, Gamradt, Seth C., additional, Glaspy, John A., additional, McBride, William H., additional, Mukherji, Bijay, additional, and Economou, James S., additional

Published
1998
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287. Opportunities and challenges of radiotherapy for treating cancer

Author

Schaue, Dörthe and McBride, William H.

Abstract

Radiotherapy needs a paradigm shift to include biological interventions that are tailored to radiation-related phenomenaDNA-repair mechanisms are obvious targets for interventions aimed at improving the radiotherapeutic benefitChromatin structure and nuclear architecture critically influence the dynamics and extent of DNA damage and repair, and thus the response to radiationCells exist along a wide spectrum of radiation responsiveness, with cancer stem cells generally being radioresistantRadiation therapy can be an antitumour immune adjuvant and new approaches to immunotherapy will offer the opportunity to exploit this interactionBiomarkers that are redox-related or immune-related might help evaluate the status of patients with cancer and provide insight into how best to combine radiotherapy with biological treatments in each individual

Published
2015
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298. ADENOVIRUS-MEDIATED GENE TRANSFER IN THE TRANSPLANT SETTING

Author

CSETE, MARIE E., primary, DRAZAN, KENNETH E., additional, BREE, MARK VAN, additional, MCINTEE, DIANE F., additional, MCBRIDE, WILLIAM H., additional, BETT, ANDREW, additional, GRAHAM, FRANK L., additional, BUSUTTIL, RONALD W., additional, BERK, ARNOLD J., additional, and SHARED, ABRAHAM, additional

Published
1994
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