2,910 results on '"Maurice, F"'
Search Results
252. An Introductory Electrical Engineering Lesson On Operational Amplifiers
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Sia Yiu, Paul Lo, E. J. Mastascusa, and Maurice F. Aburdene
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- 2020
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253. A Dynamic Parameter Estimation Experiment That Is Remotely Accessible Via Internet
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Richard J. Kozick and Maurice F. Aburdene
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- 2020
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254. Lack of Change in the Projected Frequency and Persistence of Atmospheric Circulation Types Over Central Europe
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Sven Kotlarski, Cornelia Schwierz, Erich M. Fischer, Simon C. Scherrer, Maurice F. Huguenin, and Reto Knutti
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Atmosphere ,Geophysics ,Atmospheric circulation ,General Earth and Planetary Sciences ,Environmental science ,Circulation (currency) ,Persistence (discontinuity) ,Atmospheric sciences - Published
- 2020
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255. Lack of Change in the Projected Frequency and Persistence of Atmospheric Circulation Types Over Central Europe
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Huguenin, Maurice F., Fischer, Erich M., Kotlarski, Sven, Scherrer, Simon C., Schwierz, Cornelia, and Knutti, Reto
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Persistence ,Europe ,Circulation ,Atmosphere ,Frequency ,Central - Abstract
In recent summers, Europe experienced record‐breaking heatwaves, wildfires (in Northern Europe), and large‐scale water scarcity. Apart from anthropogenic warming, one contribution leading to such exceptionally hot weather was a weaker jet stream allowing a quasi‐stationary high‐pressure system to persist for many days. Here, we quantify changes in the frequency and persistence of the Central European large‐scale circulation types using various climate models. Independent of the circulation type, the models project warmer and drier future summer conditions in Central Europe, but no consistent shift to a more persistent summer or winter circulation. Most of the frequency and persistence changes are small and either within the internal variability or inconsistent across models. The model projections in this study do not support the claim of more persistent weather over Central Europe. Reconciling the results of different approaches and classifications is therefore critical to understand and predict changes in extreme weather over Europe., Geophysical Research Letters, 47 (9), ISSN:0094-8276, ISSN:1944-8007
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- 2020
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256. Reinforcement Theory: A Practical Tool
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Villere, Maurice F. and Hartman, Sandra S.
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- 1991
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257. Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke
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Horan, Martin, Newsway, Vicky, Yasmin, Lewis, Mark D., Easter, Tammy E., Rees, D. Aled, Mahto, Arti, Millar, David S., Procter, Annie M., Scanlon, Maurice F., Wilkinson, Ian B., Hall, Ian P., Wheatley, Amanda, Blakey, John, Bath, Philip M. W., Cockcroft, John R., Krawczak, Michael, and Cooper, David N.
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- 2006
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258. CRAFT AND HANDIWORK
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Hurley, Maurice F., primary
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- 2013
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259. Hypoxemia After Percutaneous Mitral Valve Replacement: Management
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James A. DiNardo, Andrew Maslow, Maurice F. Joyce, Tzonghuei Chen, and Michelle Gorgone
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medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Echocardiography, Three-Dimensional ,Hypoxemia ,Postoperative Complications ,Mitral valve ,Internal medicine ,medicine ,Humans ,Hypoxia ,Aged, 80 and over ,Heart Valve Prosthesis Implantation ,business.industry ,Mitral valve replacement ,Mitral Valve Insufficiency ,Hypoxia (medical) ,medicine.disease ,Pulmonary hypertension ,Oxygen ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Cardiology ,Mitral Valve ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Transesophageal ,Mitral valve surgery - Published
- 2018
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260. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion
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Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Mihaila, Silvia M, Faria, João, Stefens, Maurice F J, Stamatialis, Dimitrios, Verhaar, Marianne C, Gerritsen, Karin G F, Masereeuw, Rosalinde, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Mihaila, Silvia M, Faria, João, Stefens, Maurice F J, Stamatialis, Dimitrios, Verhaar, Marianne C, Gerritsen, Karin G F, and Masereeuw, Rosalinde
- Published
- 2020
261. Simulation of distributed algorithms using OCCAM.
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Andrew E. Love Jr and Maurice F. Aburdene
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- 1990
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262. Aspects of spacecraft charging in sunlight
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Lai, Shu T. and Tautz, Maurice F.
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Photoemission -- Analysis ,Reflectance -- Measurement ,Space ships -- Electric properties ,Space ships -- Research ,Space vehicles -- Electric properties ,Space vehicles -- Research ,Business ,Chemistry ,Electronics ,Electronics and electrical industries - Abstract
This paper is an overview of spacecraft charging in sunlight. The daylight photoelectron flux emitted from spacecraft surfaces normally exceeds the ambient electron flux. As a result, charging of spacecraft surfaces to positive voltage is expected to occur in sunlight. Indeed, spacecraft are often observed to charge to low positive voltages in sunlight. However, spacecraft can charge to high-level (kiloelectronvolts) negative voltages in sunlight. Why do spacecraft charge negatively in sunlight? One chief reason concerns differential charging between the sunlit and dark sides. For a satellite with dielectric surfaces, an electric field builds up on the shaded surfaces and then wraps around to the sunlit side to form a potential barrier that suppresses the photoemission. A monopole-dipole (for zero spin) or monopole-quadrupole model (for fast spin) describes the differential charging potential distribution due to blocked photoelectrons. It is shown that these cases are similar to a more general multipole potential field in that the surface node potentials satisfy an approximate linear relation. These cases are all driven by the shade side charging so that the onset for charging is approximately the same in sunlight or eclipse if conduction currents through the spacecraft can be neglected. If conduction currents are important, potential barriers can develop on the dark side, leading to suppression of the secondary emission currents and modification of charging onset. The results were briefly compared with observations. Another important reason for negative charging concerns reflectance. Highly reflective mirrors generate substantially reduced photoemission so that current balance can be achieved without barrier formation. The onset for charging in this case depends strongly on the reflectivity. The critical temperature for charging of surface materials under space substorm conditions with different ratios of photoemission current to electron ambient current, corresponding to varying satellite surface reflectivity values, was calculated. Numerical results, which show that with substantially reduced photoemission, highly reflective surfaces charge in sunlight with the critical temperature for onset decreasing with increasing reflectivity, are presented. Index Terms--Monopole-dipole, monopole-quadrupole, photo-emission, reflectance, spacecraft charging, sunlight charging.
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- 2006
263. A Case Study in Archaeology and Public Benefit from an Urban Excavation in an Old Brewery: Cork City, Ireland
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Hurley, Maurice F., primary
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- 2021
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264. Depression After Traumatic Brain Injury: A Review of Evidence for Clinical Heterogeneity
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Moldover, Joseph E., Goldberg, Kenneth B., and Prout, Maurice F.
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- 2004
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265. Simultaneous Localization and Mapping in Marine Environments
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Fallon, Maurice F., primary, Johannsson, Hordur, additional, Kaess, Michael, additional, Folkesson, John, additional, McClelland, Hunter, additional, Englot, Brendan J., additional, Hover, Franz S., additional, and Leonard, John J., additional
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- 2012
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266. Only One Earth
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Dodds, Felix, primary, Strauss, Michael, additional, and Strong, with Maurice F., additional
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- 2012
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267. The use of poly-L-lactic acid in lumbar interbody cages: design and biomechanical evaluation in vitro
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van Dijk, Martijn, Smit, Theo H., Arnoe, Maurice F., Burger, Elisabeth H., and Wuisman, Paul I.
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- 2003
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268. Treating complex trauma in women within community mental health
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Chaikin, Nicole D. and Prout, Maurice F.
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Psychic trauma -- Care and treatment ,Mental health ,Health ,Psychology and mental health - Abstract
Community mental health clinicians are likely to find their case loads composed of women who have complicated trauma histories. In response to the absence of comprehensive treatment for trauma survivors within the community mental health system, an alternative model, OPAL, is offered. As an intensive treatment program, OPAL is structured in a triphase format to accommodate the individual needs of each woman and to promote symptom reduction and/or resolution.
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- 2004
269. Spectroscopic Methods
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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270. Sources
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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271. Detectors
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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272. Terahertz Imaging
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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273. Optical Components
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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274. Introduction
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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275. Optical Principles at Terahertz Frequencies
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Bründermann, Erik, primary, Hübers, Heinz-Wilhelm, additional, and Kimmitt, Maurice F., additional
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- 2011
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276. Differential block coding of bilevel images.
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George R. Robertson, Maurice F. Aburdene, and Richard J. Kozick
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- 1996
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277. Conservation Committee Report on Effects of Alteration of Sagebrush Communities on the Associated Avifauna
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Baker, Maurice F, Eng, Robert L, Gashwiler, Jay S, Schroeder, Max H, Braun, Clait E, and BioStor
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- 1976
278. Wow! linear systems and signal processing is fun!
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Maurice F. Aburdene and Kundan Nepal
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- 2011
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279. Methods for designing efficient parallel‐recursive filter structures for computing discrete transforms
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Kozick, Richard J. and Aburdene, Maurice F.
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- 2000
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280. Effects of posttraumatic stress disorder and child sexual abuse on self-efficacy development
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Diehl, Amy S. and Prout, Maurice F.
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Child sexual abuse -- Psychological aspects ,Self-actualization (Psychology) ,Post-traumatic stress disorder ,Self-realization ,Health ,Psychology and mental health - Abstract
The symptoms of child sexual abuse and posttraumatic stress disorder (PTSD) affect a child's self-efficacy. A child's self-efficacy beliefs impact the course and treatment of PTSD, because perceived self-efficacy plays a mediating role in children's ability to cope with trauma. Self-efficacy research indicates that emotional competence can be learned and may provide treatment for PTSD that provides symptom reduction as well as a means of substituting problem-solving coping skills for emotion-focused coping skills.
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- 2002
281. Un diabète sympathique
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Dongala, A., primary, Khiari, M., additional, Taillard, V., additional, Maurice, F., additional, Gilly, O., additional, and Guedj, A.M., additional
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- 2020
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282. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion
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Mihaila, Silvia M., primary, Faria, João, additional, Stefens, Maurice F. J., additional, Stamatialis, Dimitrios, additional, Verhaar, Marianne C., additional, Gerritsen, Karin G. F., additional, and Masereeuw, Rosalinde, additional
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- 2020
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283. Range Equation for Hybrid-Electric Aircraft with Constant Power Split
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de Vries, Reynard, primary, Hoogreef, Maurice F. M., additional, and Vos, Roelof, additional
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- 2020
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284. Wood Dust Levels in Alberta Sawmills
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Yamanaka, Michael W., Guidotti, Tee L., Koehncke, Niels, Taylor, Maurice F., Taylor, Chris, and Harman, Lloyd
- Published
- 2009
285. Effects of Dehydroepiandrosterone Replacement on Vascular Function in Primary and Secondary Adrenal Insufficiency: A Randomized Crossover Trial
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Rice, Sam P. L., Agarwal, Neera, Bolusani, Hemanth, Newcombe, Robert, Scanlon, Maurice F., Ludgate, Marian, and Rees, D Aled
- Published
- 2009
286. A new phenanthrene derivative from Entada abyssinica with antimicrobial and antioxidant properties.
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Magnibou, Larissa M., Leutcha, Peron B., Tchegnitegni, Billy T., Wouamba, Steven C. N., Magne, Cyrille Y. F. F., Yaya, Abel J. G., Kopa, Theodora, Tagatsing, Maurice F., Tombozara, Nantenaina, Meli, Alain L., Henoumont, Celine, Laurent, Sophie, and Talla, Emmanuel
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PHENANTHRENE derivatives ,PHENANTHRENE ,PATHOGENIC fungi ,SALMONELLA enterica ,ANTIOXIDANT testing ,NUCLEAR magnetic resonance spectroscopy ,CANDIDA albicans ,CANDIDA - Abstract
Entada abyssinica Steud. Ex A. Rich (Leguminosae) is a medicinal plant used traditionally for the treatment of infections. A phytochemical investigation of the methanol extract of E. abyssinica root bark led to the isolation of a new phenanthrene derivative named phenentada (1), together with seven known compounds (8 S, 13 E)-kolavic acid 15-methyl ester (2) and 8 S-kolavic acid 15-methyl ester (3) obtained as mixture, 8 S-kolavic acid 15-methyl ester (3), 8 S-kolavic acid 18-methyl ester (4), 13,14,15,16-tetranorclerod-3-ene-12,18-dioic acid (5), 1′,26′-bis-[(S)-2,3-dihydroxypropyl] hexacosanedioate (6), campesterol (7) and 3-O-β-d-glucopyranosylstigmasterol (8). Their structures were determined by NMR spectroscopy (1D and 2D), mass spectrometry (HRESIMS) and by comparison with previously reported data. The crude extract and some isolated compounds were evaluated for their in vitro antimicrobial activities by the microdilution method while, the antioxidant activity was evaluated by the DPPH methods. Regarding the antimicrobial activity, the crude extract showed significant inhibitory activities against bacteria strains (MIC 7.81–31.3 μg mL
−1 ) and yeasts (MIC 15.6–31.3 μg mL−1 ) whereas all compounds tested exhibited significant activity against Staphylococcus epidermidis. Moreover, compounds 4, 5 and 6 and the mixture 2/3 showed significant antimicrobial activity on Candida parapsilosis strain (MIC = 3.12 μg mL−1 ), as well as selected antifungal property against candida pathogenic fungi strains. On the other hand, compounds (1) demonstrated the best bioactivities against Candida albicans and Salmonella enterica with MIC = 3.12 μg mL−1 while the mixture 2/3 appeared to have the highest inhibition on gram (+) bacteria strain S. epidermidis with MIC of 0.78 μg mL−1 and compound 5 (MIC = 1.56 μg mL−1 ) against the gram (−) bacteria strain. Furthermore, the SC50 values measured by the antioxidant test for all samples varied between 47.21 and 52.44 μg mL−1 for DPPH. These results support the traditional uses of E. abyssinica in the management of several diseases including the claim in the skin disease treatment. Additionally, here is reported the first time isolation of a phenanthrene derivative in the Fabaceae family to the best of our knowledge. [ABSTRACT FROM AUTHOR]- Published
- 2022
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287. TSH (Thyroid-Stimulating Hormone; Thyrotropin)
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Rees, D. Aled, primary and Scanlon, Maurice F., additional
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- 2004
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288. Repairing relationships and restoring trust: behavioral finance and the economic crisis.
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Gounaris, Kathleen M. and Prout, Maurice F.
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Financial services industry -- Customer relations ,Customer relations -- Psychological aspects ,Consumer behavior -- Management ,Financial services industry ,Company business management - Published
- 2009
289. Management Strategies in Geriatric Trauma Care
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Maurice F. Joyce, Justin Benoit, and Ruben J. Azocar
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Population ,Disease ,medicine.disease ,Traumatic injury ,Geriatric trauma ,Geriatric population ,Orthopedic surgery ,Medicine ,business ,Intensive care medicine ,education - Abstract
The geriatric population is rapidly growing, and they are leading an increasingly active lifestyle resulting in a brisk and continuing increase in the incidence of traumatic injury in this population. Due to normal physiologic changes associated with aging and an increased prevalence of coexisting disease, it is expected that traumatic injuries in geriatric patients would be associated with a higher morbidity and mortality. However, the current statistics are dismal, and the economic impact is enormous. It is imperative that we improve. This chapter will provide a brief overview of the normal physiologic changes associated with aging and then discuss a geriatric-specific approach to the triaging, evaluation, and management of these patients with a particular focus on orthopedic and neurologic traumatic injuries. It will conclude with a brief discussion of the concept of clinical momentum as it relates to the management of traumatic injuries in the geriatric population.
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- 2019
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290. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA
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McGuire D, Alexander J, Johansen O, Perkovic V, Rosenstock J, Cooper M, Wanner C, Kahn S, Toto R, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, Marx N, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, Commendatore V, Tedesco J, Bolzan P, Cuneo C, Narcisa G, Caputi V, Pablo S, Sandra G, Pacora F, Tinari M, Jure H, Parody M, Toranzo A, Frechtel G, Yohena S, Lovecchio S, Muller C, Martin S, Olivera C, Breyaui M, Bianchi G, Garcia C, Luciana V, Florencia F, Ruben G, Gelersztein E, Rey G, Sanchez C, Fornasari L, Di Pierro L, Giacomi G, Miguel S, Laura T, Gonzalo C, Ramon C, Glenny J, Koretzky M, Porto A, Tiberio O, Ellenberg A, Saurral R, Igarzabal C, Vilamajo O, Matkovich J, de Lapertosa S, Villagra M, Cuzziol G, de la Cruz M, Pinchetti R, Mierez M, Lopez C, Gorosito V, Gabito A, Kleiban A, Grosembacher L, Adrian P, Paula R, Javier G, Kraft F, Andres F, Krynski F, Nicolas P, Marcelo F, Alfredo F, de la Fuente R, Natalia C, Luquez H, Recuero Y, Becchetti N, Ruiz M, Costantino M, Vazquez G, Guzman C, Pelatia P, Maffei L, Sassone S, Yantorno M, Prado G, Khron B, Maldonado N, Gustavo L, Veronica V, Marino J, Elizabeth A, Alejandra C, Oscar R, Azize G, Gallardo M, Escudero M, Vargas E, Ramos H, Lucero C, Najenson M, Crocci I, Chiesa A, Nardone L, Dominguez S, Zanini A, Manghi F, Grossman M, Giudice G, Romeo A, Piskorz D, Miguel C, Susana D, Noeli U, Rosa S, Martin V, Soledad A, Virginia M, Lorena G, Prado A, Veronica L, Eduardo H, Adolfo P, Florencia W, Rista L, Scolari C, Rojas N, Bertolio V, Zarandon R, Jair S, Orlando C, Sanabria H, Ignacio D, Viviana C, Marina R, Sarjanovich R, Scaro G, Huerta C, Mana M, Gutierrez M, Dain A, Gavicola R, Sessa H, Sacripanti J, Felman R, Vilarino P, Sicer M, Lagrutta M, Sala J, Casabella T, Cecilia H, Carlos B, Vines G, Javier R, Vico M, Lanchiotti P, Martella C, Torres L, Villarino A, Molina M, Martinez J, Farias C, Bertola S, Rojas M, Guzman P, Nisi J, Martinez D, Barrionuevo M, Vita N, Lopez A, Vottero E, Giuliano M, Paron L, Vogel D, Mele P, Imposti H, Dominguez A, Zaidman C, Fernando G, Beck M, Beltrame P, Chemello D, Junior R, Abreu A, Fernandes V, Saboia J, Rodrigues L, Carvalho M, Gurgel M, Gadelha D, Ramos C, Borba V, Golbert M, Pitthan M, Golbert L, Valentini R, Canani L, Gross J, Valenti A, Sartori C, Dutra O, Azevedo E, Azevedo A, Vaz R, Vaz H, da Costa F, da Costa L, Panarotto D, Lain F, Camazzola F, Dellomea B, Rech R, Pizzato P, Nunes C, Jaeger C, Silveira D, Wagner L, Machado L, Rea R, de Bem A, Alves J, Jonasson T, Malucelli F, Betti R, Lerario A, Lisboa H, Bem J, Tres G, Tavares C, Nardi A, Pozzatto M, Backes L, Reolao J, Scariot E, Ziguer E, Baldissera D, Griz L, Antunes D, Victor F, Freire K, Barros A, Costi B, Sa M, Carneiro A, Felicio J, Felicio K, Penha P, Ferreira J, Melo F, Alves A, Souza A, Costa L, Pinheiro D, Turatti L, Augusto G, Leanca C, Santomauro A, Forti A, Sena R, Marinho A, Facanha C, de Souza K, de Souza A, de Queiroz W, Leite S, Vieira S, Gubert L, Olsen A, Piazzetta G, Fuck A, Ferreira M, Fortes J, Brandao T, Alves F, Radice E, dos Santos J, de Almeida R, Franco D, Saporito W, Eliaschewitz F, de Siqueira K, Bona R, Genestreti P, de Castro D, Visconti G, Sampaio C, Palhares F, Konigsfeld H, Alves E, Feder C, Leao B, Saraiva J, Rodovalho S, Costa M, Pires N, Figueiredo E, Werner G, Garcia J, de Paiva I, Quirino B, Botelho R, da Silva R, Navarro A, Lourenco C, Pereira A, Arantes F, Boner D, Saad J, Falchetto E, Washizu E, Mandil A, Pimenta N, Tofani F, Fonseca T, Teixeira L, Maia L, Lemos M, Mouco O, Nakazone M, Weiand L, Bohn J, Hissa M, Araripe F, Carvalho F, Cancado G, Wang R, Chacra A, Fusaro A, de Mendonca E, Cercato C, Halpern A, Alves B, Braile M, Sestito R, Mustafa E, Ferreira V, Sbardellini B, de Almeida P, Guimaraes F, Piedade M, Bienert I, Braga J, Daher R, Hirakawa T, Terra E, Farias E, Figueiredo M, Lima L, Moraes K, Avelino I, Flato U, Plavnik F, Portes E, Moreira M, Vendramini M, Veloso R, Padilha M, Rodrigues A, Adam R, Santos S, Sayeg N, Guerrero D, Madeira M, Siqueira J, Pinheiro R, Villacorta A, Mellazi A, Braga T, Kaiser S, Paolino B, Lefterov I, Marinchev A, Angelova S, Klyuchkova N, Lybomirova Z, Kerekovski Y, Kuneva T, Penkova D, Levterov G, Videnova E, Georgieva P, Shinkov A, Borissova A, Vlahov J, Dakovska-Dekova L, Lucheva M, Luchev P, Temelkova M, Borisova K, Tsenov S, Andreeva V, Margaritov V, Arasheva G, Lozanov L, Borisov R, Gorcheva D, Henein S, Whatley S, Boutros M, Kalyniuk N, Berlingieri J, Nisker W, Hoag G, Hepburn D, Harvey M, Manjoo P, Yale J, Sherman M, Tsoukas M, Rehman W, Mason M, Santerre M, De Kock J, Barkhuizen F, Rooke C, Gill C, Kooy J, Burgoyne G, de Kock J, Degen G, Hockman L, Invik R, Roberts P, Ward K, Alasaad H, Susan A, Davies V, Gupta N, Milhalidis J, Grossman L, Agawal N, Yared Z, Rwaheed, Nouhad S, Nahla A, Khandwala H, Warwick A, Wadehra D, Manan A, Vecchiarelli J, Aslam N, Ferrao A, St-Maurice F, Collette R, Davey B, Nawaz S, Coutu B, Costi P, Greiss I, Mansour F, Raymond J, St-Phard W, Nadra I, Della Siega A, Barahona L, Klinke P, Contractor H, Fryer M, Chandra N, Conti B, Telzer L, Sorensen S, Lounsbury N, Martin E, Mitchell L, Pelzer E, Nelson S, Jones M, Cox J, Luco G, Trhoughton T, Labonte R, Chouinard G, Frechette A, Rheaume M, Cusson J, Faucher J, Dery V, Kelly A, Miranda B, Al-Kayssi N, Malette P, Rheault P, Fredette P, Dumas R, Palardy J, Belanger A, Boucher P, Doyon B, Charbonneau J, Bailey G, Odendaal M, Stephan K, Badenhorst J, Knight D, Thurgood A, Johnston M, Cooper-Rosen E, Jagger R, Green M, Weisnagel S, Gangloff A, Bergeron J, Pesant Y, Chevalier P, Woo V, Hurd C, Ruckert G, Lira J, Navarro G, Venegas M, Gonzalez P, Montecinos H, Vidal G, Fernandez M, Varas J, Fernandez C, Aguilar J, Marin R, Kindel C, Yovaniniz P, Gherman O, Aravena M, Carvajal J, Macias E, Corrado P, Lazcano M, Garrido B, Charme G, Carrasco J, Vignolo P, Saavedra S, Gajardo V, Saavedra C, Santamaria D, del Castillo B, Balda I, Zurvarra V, Fu G, Jiang D, Huang H, Wang M, Song J, Lu W, Lin Y, Lu Z, Shi Y, Zhong M, Zhao X, Chen D, Zhang G, He Y, Shi P, Chu K, Gao Q, Deng W, Zhang J, Zhang Y, Chen H, Liu E, Xie Y, Lin R, Tan W, Yuan Z, Wang Y, Ren J, Yu H, Luo M, Ma W, Shi W, Xu H, Xu M, Liu G, 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Kitamura H, Toriumi Y, Ishiguro H, Naganuma T, Shu S, Suzuki K, Hirota Y, Hayashi T, Hozawa K, Fukui T, Abe Y, Yamauchi K, Maruyama M, Matsumura S, Kozuma R, Nagai Y, Kihara Y, Maeda H, Nakanishi K, Iitsuka T, Hatori M, Shinozaki Y, Akiyama D, Kawabe M, Takei M, Sato A, Kawai Y, Kitajima K, Ide M, Sato N, Morisaki H, Nakashima K, Takayanagi H, Watanabe H, Iwahashi N, Tsujimoto M, Hibuse K, Hata T, Ueno K, Tatsuma H, Wakida Y, Ito T, Mizuno R, Fujita H, Konishi N, Kanehira T, Watanabe R, Miyaoka H, Okada T, Yamamoto M, Okita S, Murakami H, Todo Y, Umeoka F, Hori K, Shiraishi K, Tada F, Shimizu T, Tamai J, Sasaki C, Okuzima Y, Yasuda M, Iwaita Y, Tanaka K, Rha S, Na J, Cho D, Cho Y, Hwang E, Choi T, Won K, Kim H, Kim S, Oh D, Lee J, Choi H, Chung H, Park H, Suh Y, Kim Y, Kim N, Kim K, An J, Kim J, Park K, Kwak S, Kim M, Hwangbo Y, Lee D, Hong A, Kim L, Oh C, Moon S, Jung C, Jin J, Hyun B, Yang Y, Kong S, Yoon K, Yang H, Hong T, Oh J, Park J, Lee H, Choi J, Ahn J, Han S, Park W, Jo S, Suh S, An W, Park M, Lee S, Kim D, Jin H, Seo J, Chung C, Lim J, Huh J, Park I, Yu S, Sim N, Khan S, Albakari N, Sivaraman J, Manaf K, Maharuddin I, Nagendram S, Ali N, Abdul Latiff N, Othman N, Sarip S, Chew E, Mohamed S, Aziz N, Hui K, Lin L, Velaiutham S, Khir A, Lee L, Manikam S, Chooi K, Chang M, Ooi C, Anthony J, Seganathirajah M, Ng O, Ismail N, Cheah C, Ramanathan G, Mui N, Wen F, Choo T, Bin Ruhani A, Jamaludin S, Abidin S, Nor F, Abu Hassan M, Hanari N, Ahmad N, Suan M, Zainul N, Ali S, Sridhar G, Han C, Chin A, Vin L, Kadir K, Zain A, Hussain N, Pusparajah P, Lozano F, Gomez A, Zaccari E, Vigil A, Preciado C, de Leon M, Parra M, Cervantes A, Aguirre E, Orozco E, Gonzalez S, Elizondo R, Flores E, Guerrero M, Flores F, Sanchez J, Perez F, Rodriguez J, Martinez L, Marquez D, Gutierrez B, Flores M, Real M, Campos P, Garcia P, Rios M, Romero E, Perez Z, Tarabay C, Munoz L, Farias J, Gonzalez J, Palestino N, Sanchez L, Carrillo G, Ordonez N, Pech C, Andrade M, Euan J, Ortegon M, Garcia S, Orozco J, Vazquez H, Herrera R, Perez E, Arango A, Ibarra M, Gonzales L, Esperano J, Quintana L, Salazar I, Ruiz L, Barron C, Ballesteros C, Cervera L, Hercilla E, Gomez H, Mesa J, Herrera P, Rodriguez M, Ochoa R, Mora E, Charles C, Silva R, Mijangos J, Diaz C, Zavala C, Baron P, Bernal A, Martinez F, Tlapale M, Ramirez E, Basila A, Munguia R, Tello M, Martinez M, Mulder H, van der Graaff P, Nawaz A, Keller I, Schoofs M, Smak-Gregoor P, Al-Windy N, Bulut S, de Jong J, Maas A, Schaardenburgh P, Imholz B, Heijster J, Hoogenberg K, Smit C, Kooy A, Huvers F, Landewe-Cleuren S, Kars M, van Moorsel D, Wolffenbuttel B, Lutgens H, Schutte E, Gansevoort R, Idzerda N, Westerink J, Weijmans M, Berg J, van Kleef M, Slob M, Jaspers N, Hovens M, Monajemi H, Kobielusz-Gembala I, Zmuda W, Adamczyk M, Konieczny M, Strzelecka-Sosik A, Nowacka E, Krzyzagorska E, Sekulska M, CzajkowskaKaczmarek E, Kaczmarek B, Opawska K, Dabrowska M, Kus W, Wrzesien-Kus A, Piotrowski G, Hotlos L, Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, Gmytrasiewicz M, Zambrzycki J, Krysiak-Kowaluk H, Klodawska K, Klszczewski Z, Zieleniewski J, Opadczuk P, Urbanska K, Faran-Grabowska K, Szczepanik T, Siegel A, Kleczek A, Kincel K, Nowak D, Slowik-Gomulka L, Watemborska-Matuszyk G, Lampart J, Strozik-Krecichwost A, Dziewit T, Broncel M, Wojcik-Odyniec J, Jakubczyk E, Wierzbicka K, Witowicz A, Jedrych B, Korczyk P, Socik-Pojawa M, Monteiro P, Monteiro S, Mendes P, Soares F, Mendes S, Leite L, Vicente J, Santos M, Ferreira A, Alves P, Rosario F, Garrao A, Duarte L, Rogado C, Duarte R, Laginha T, Matos P, Raposo J, Mariz J, Teixeira J, Capela C, Leitao A, Cardiga R, Alface M, Augusto S, Basto L, Cunha A, Rei D, Dantas J, Verdasca I, Andrade L, Silva A, Suarez M, Dias V, Silva J, Pereira N, Goncalves M, Goncalves A, Silveira A, Sampaio A, Dias A, Diogo M, Vilaca C, Cif A, Calin T, Elena S, Crisan C, Adina S, Ramona S, Anghel V, Simona C, Turcu L, Mihaela V, Cosma D, Cristina H, Marius-Calin H, Negrisanu G, Andreea-Andrada M, Maria-Mihaela V, Camelia T, Oana P, Monia A, Onaca A, Mircea O, Mot A, Stolea V, Elena N, Barbonta D, Cristian B, Oana S, Popescu A, Madalina M, Coman A, Anca C, Constantinescu S, Mircea C, Diaconu-Sotropa M, Ene D, Pintilei E, Mihai G, Delia R, Toarba I, Simona H, Negru D, Flaminzeanu F, Iulian C, Maria-Cristina C, Doros R, Cleo S, Sorin B, Demian L, Mihai S, Raul B, Ioana A, Nicolau A, Cosmin P, Isabela G, Elena C, Ileana T, Valuyskikh E, Miroshnichenko E, Klementyeva N, Zelman O, Chumakova G, Vigel A, Leonova N, Pergaeva Y, Stefanovskaya O, Pushkareva S, Antoshkina L, Zheleznova N, Iveitsman, Barbarash O, Zvereva T, Zhuravleva E, Zavyrylina I, Usoltceva E, Savostyanova Y, Kupriyanova T, Krivoshapova K, Kondyukova N, Inozemceva A, Argunova Y, Tsyba L, Belenky D, Mariich O, Terekhova A, Tsygankova O, Kuznetsova E, Nagibovich G, Ivchenko Y, Dobronravov V, Dobronravov A, Bush M, Trofimenko I, Vishnevsky A, Zikov V, Kositsyn D, Palzman Z, Spiridonova T, Rodina N, Polozhentsev S, Mamedova L, Panov A, Abesadze I, Alugishvili M, Ivashkin V, Drapkina O, Korneeva O, Zyatenkova E, Glinkina I, Poluboyarinova I, Gurova O, Raykhman A, Vertkin A, Rodykova I, Shamaeva K, Petrovskaya T, Uzueva E, Milovanov Y, Milovanova S, Milovanova L, Markina M, Dobrosmyslov I, Markov V, Afanasiev S, Babich E, Belokopytova N, Demyanov S, Maximov A, Maximov I, Rebrova T, Shtatolkina M, Masin A, Demko A, Chuyko O, Pronina A, Charf G, Akatova E, Urlaeva I, Nikolin O, Khovaeva Y, Ermachkova L, Burdina E, Shvalb P, Suchkov I, Pshennikov A, Gryaznov S, Rymar O, Dolinskaya Y, Bahareva Y, Mustafina S, Sherbakova L, Ovsyannikova A, Bolshakova O, Polunicheva E, Dora S, Agafyina A, Yashina A, Vasilieva I, Yakhontova P, Selivanova S, Kargapoltseva O, Shilina N, Bayramova G, Sorokin I, Astamirova K, Kuchuk P, Koniushenko D, Malykh N, Dvorkin M, Krovelets T, Konovalova K, Seeber M, van Niekerk F, Siebert H, Steenkamp W, Wiid S, Noeth M, Siebert R, Breedt J, Bouwer J, Kapp C, Venter T, Rayner B, Trinder Y, Rheeder P, Delport E, Mathijs S, Soma P, van Zyl D, Strydom M, Marais A, Badat A, Hansa S, Fourie D, Walton T, Engelbrecht J, Jansen J, Roos J, du Toit S, Lehloenya K, van Zyl L, van Zyl F, Naude M, Mookadam M, van der Merwe A, Trokis J, Lombard L, Coetzee K, Ismail S, Bruning H, Latiff G, Yasmin O, Pillay T, Mohamed Z, Dawood S, Stapelberg A, Abrahams P, Jurgens J, van Heerden P, Swart E, Botha C, Meeding J, Hemus A, Oosthuysen W, Visagie G, Fourie N, Hutton P, van der Merwe N, Chelin N, Everton T, Duki M, Ghila N, Joshi M, Hira M, Madueno F, Martinez B, Sebastian N, Mercadal L, Isbert S, Gonzalez I, Asencio J, Figueras M, Rivas M, Garcia H, Fusalba A, Geat D, Cambra G, Sastre J, Castro F, Mas A, Portillo C, Serrano I, Hernandez S, Fajardo F, Juan C, Ferrer J, Peralta F, Padin C, Mauricio D, Madorell B, San Miguel F, Pedrol N, Trescoli C, Montanana C, Gonzalo M, Capellan J, Estrella A, Martinez C, Montesinos I, Loscos A, Coronado J, Perez J, Castillo B, Alonso C, Quesada V, Teruel J, Perez S, Lama M, del Rio E, Zlova T, Ponomarenko K, Karpenko O, Bezuglova S, Mitskevych L, Kizim S, Nevolina I, Katerenchuk V, Liudmyla B, Ivan K, Rudyk I, Olena M, Anna I, Ganna B, Topchii I, Semenovykh P, Yulia Y, Mykhalchyshyn G, Kirienko D, Kobiliak N, Bodnar, Mykhalchyshyn, Pertseva N, Olena G, Tomashkevych H, Korpachev V, Prybyla O, Kovalchuk A, Kushnarova N, Zinych O, Tseluyko V, Andriy Z, Olga R, Mankovskyy B, Zherdova N, Lykhoshapko O, Logoida P, Godlevska O, Olena V, Olga C, Gyrina O, Alifer O, Dozhuk K, Pekhenko V, Gorobets N, Korneichuk A, Makarenko E, Martynyuk L, Martynuyk O, Stanislavchuk M, Larysa P, Natalia S, Botsyurko V, Kostitska I, Dzeman O, Ablitsov Y, Ivaseiko S, Konovart O, Sandurska S, Vendzilovych Y, Samoylov O, Iryna C, Rozhkivska L, Ulyanchenko I, Kateryna V, Orlenko V, Ivaskina K, Tronko M, Tronko K, Pashkovska N, Stankova N, Vynnychenko L, Bolotnikova N, Demokhova N, Reshotko D, Popova A, Dr Bogdana, Tetiana S, Svitlana D, Oksana R, Vlasenko M, Litvinova S, Semenyuk I, Fishchuk O, Mostovoy Y, Tkachenko T, Ovcharuk M, Rasputina L, Vakaliuk I, Tymochko N, Drapchak I, Petrovska L, Lai W, Yen H, Voon W, Lin T, Cheng K, Chiu C, Chu C, Hsu P, Chiang C, Li Y, Kuo C, Lin S, Chao T, Yu W, Sung S, Wang K, Lu T, Shih K, Wu C, Chiang F, Hwang J, Tsai C, Juang J, Jeng J, Tang S, Lai C, Cheng C, Hsieh I, Hsieh M, Chen C, Lee C, Pai P, Ko P, Wang T, Chen T, Wu H, Chang S, Chen K, Hsieh L, Chou C, Jiang J, Lee M, Huang J, Chen J, Chiu K, Tsai L, Chen P, Saxena M, Collier D, Vaidya B, Harman S, Ramell M, Davies M, Chatterjee S, Meakin L, Quinn M, Bain S, Mallipedhi A, Min T, Bashir J, Blagden M, Ali J, McCrimmon R, Brennan G, Malcolm E, McDonald D, Pearson E, Illsley G, Darzy K, Winocour P, Hanif W, Cockwell P, Charlton M, Thekkepat S, Howat I, Devers M, Patrick J, Wyatt N, Smith C, Singh B, Nicholas J, Gillani S, Green F, Bell E, Boyle J, MacKin S, Livingstone R, Arif A, Syed M, Hammoud J, Sparks J, Anderson M, Tumey R, Condit J, Reddy M, Abalos-Galito M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, Harris B, Levy R, Siev E, Berlin H, DiMattia M, Sugimoto D, Dugas J, Benson M, Stegemoller R, Schmoll M, Kinnaman S, O'Connor T, Powel T, Rudolph L, Lewiecki M, Best E, Chavez J, Garcia M, Cohen R, Colman D, Ocampo M, Heaney L, Rappley G, Quezada I, Santos V, Nikfarjam A, Reyes M, Rodriguez R, Josephs L, Hernandez R, Flores P, Espinoza L, Mejia W, Pedraza Z, Castaneda R, Laguerre J, Cook R, Patel R, Werner H, Blank R, Small S, Andersen J, Holmes D, Farmer M, Wiener V, Pharr W, Bray B, Beekman J, Anderson A, Andrawis N, Gabra N, Moche T, Marty S, Galvez O, Reyes R, Garcia R, Lerma G, Pliquin B, Mayfield R, Durham N, Phillips R, Baran A, Kondo N, Dempsey S, Kufs W, Laddis T, Zimmer K, Van Depol M, Dweck L, Kestler M, Werner N, Ashraf M, Quick A, Schallert G, Sligh T, Trueba P, Batista J, Martinez T, Moya J, Amarales V, Santos E, Torres P, Diaz T, Diaz J, Hodish I, Else T, Buras E, Moratis A, Valika S, Rahman A, Malalis W, Box E, Box P, Kerwood B, Nagaeva J, Metz C, Hinnant J, Griswell D, 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Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
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cardiovascular disease ,type 2 diabetes mellitus ,heart failure ,chronic kidney diseases - Abstract
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532.
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- 2019
291. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk The CARMELINA Randomized Clinical Trial
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Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
- Abstract
IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. OBJECTIVE To evaluate the effect of linagliptin, a selective DPP-4 inhibitor, on CV outcomes and kidney outcomes in patients with type 2 diabetes at high risk of CV and kidney events. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, multicenter noninferiority trial conducted from August 2013 to August 2016 at 605 clinic sites in 27 countries among adults with type 2 diabetes, hemoglobin A(1c) of 6.5% to 10.0%, high CV risk (history of vascular disease and urine-albumin creatinine ratio [UACR] > 200mg/g), and high renal risk (reduced eGFR and micro-or macroalbuminuria). Participants with end-stage renal disease (ESRD) were excluded. Final follow-up occurred on January 18, 2018. INTERVENTIONS Patients were randomized to receive linagliptin, 5 mg once daily (n = 3494), or placebo once daily (n = 3485) added to usual care. Other glucose-lowering medications or insulin could be added based on clinical need and local clinical guidelines. MAIN OUTCOMES AND MEASURES Primary outcomewas time to first occurrence of the composite of CV death, nonfatalmyocardial infarction, or nonfatal stroke. Criteria for noninferiority of linagliptin vs placebo was defined by the upper limit of the 2-sided 95% CI for the hazard ratio (HR) of linagliptin relative to placebo being less than 1.3. Secondary outcome was time to first occurrence of adjudicated death due to renal failure, ESRD, or sustained 40% or higher decrease in eGFR from baseline. RESULTS Of 6991 enrollees, 6979 (mean age, 65.9 years; eGFR, 54.6 mL/min/1.73m2; 80.1% with UACR > 30mg/g) received at least 1 dose of study medication and 98.7% completed the study. During a median follow-up of 2.2 years, the primary outcome occurred in 434 of 3494 (12.4%) and 420 of 3485 (12.1%) in the linagliptin and placebo groups, respectively, (absolute incidence rate difference, 0.13 [95% CI,-0.63 to 0.90] per 100 person-years) (HR, 1.02; 95% CI, 0.89-1.17; P
- Published
- 2019
292. Recursive computation of discrete Legendre polynomial coefficients
- Author
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Aburdene, Maurice F.
- Published
- 1996
- Full Text
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293. The role of mineral metabolism and inflammation on dialysis vascular access failure
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MORENA, M., BOSC, J. Y., JAUSSENT, I., DUPUY, A. M., TERRIER, N., LERAY-MORAGUES, H., FLAVIER, J. L., MAURICE, F., DELCOURT, C., CRISTOL, J. P., and CANAUD, B.
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- 2006
294. Psychological implications of retirement in the 21st century.
- Author
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Matour, Susan and Prout, Maurice F.
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Retirement -- Psychological aspects ,Financial planning -- Psychological aspects - Published
- 2007
295. Unification of Legendre, Laguerre, Hermite, and binomial discrete transforms using Pascal's matrix
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Aburdene, Maurice F. and Dorband, John E.
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- 1994
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296. Constitutional law - freedom of speech - New Jersey State Constitution requires privately owned shopping malls to allow access for expressional leafletting, subject to the owner's reasonable time, place, and manner restrictions.
- Author
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Kirchofer, Maurice F., III
- Subjects
Freedom of speech -- Cases ,Shopping centers -- Cases ,Public forum doctrine (Law) -- Cases ,New Jersey Coalition Against War in the Middle East v. J.M.B. Realty Corp. (650 A.2d 757 (N.J. 1994)) - Published
- 1997
297. Differential responses of rat cerebral somatostatinergic and cholinergic cells to glutamate agonists
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Ham, Jack, Duberley, Ruth, Rickards, Carole, and Scanlon, Maurice F.
- Published
- 1993
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298. On the computation of discrete Legendre polynomial coefficients
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Aburdene, Maurice F.
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- 1993
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299. Persistence and determinants of statin therapy among middle-aged patients for primary and secondary prevention
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Perreault, S., Blais, L., Lamarre, D., Dragomir, A., Berbiche, D., Lalonde, L., Laurier, C., St-Maurice, F., and Collin, J.
- Published
- 2005
300. ANTIOXIDANT STATUS OF INSULIN DEPENDENT DIABETICS
- Author
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Cser, M. Agnes, primary, Sziklai-László, I., additional, Laryea, Maurice F., additional, and Lombeck, Ingrid, additional
- Published
- 1999
- Full Text
- View/download PDF
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