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256. Plasma proteome profiles of stable CAD patients stratified according to total Apo CIII levels

Author

Conte, E, Chiarello, C, Castagna, A, Robotti, E, Gosetti, F, Patrone, M, Martinelli, N, Bassi, A, Cecconi, D, Manfredi, M, Marengo, E, Olivieri, O, Conte, E, Chiarello, C, Castagna, A, Robotti, E, Gosetti, F, Patrone, M, Martinelli, N, Bassi, A, Cecconi, D, Manfredi, M, Marengo, E, and Olivieri, O

Subjects
Plasma proteome, CAD, Apo CIII, LC-MS, CHIM/01 - CHIMICA ANALITICA
Published
2018

257. A cad system in hep-2 iif reading: a multicentre study

Author

Rigon, A., Infantino, M., Merone, M., Iannello, G., Sansone, C., Tincani, A., Cavazzana, I., Manfredi, M., Radice, A., Soda, P., Afeltra, A., Rigon, A., Infantino, M., Merone, M., Iannello, G., Sansone, C., Tincani, A., Cavazzana, I., Manfredi, M., Radice, A., Soda, P., and Afeltra, A.

Published
2018

258. Plasma Proteome profiles of stable CAD patients stratified according to total Apo CIII levels

Author

Manfredi, M, Chiariello, C, Conte, E, Castagna, A, Robotti, E, Gosetti, F, Mazzucco, E, Martinelli, N, Cecconi, D, Olivieri, O, Marengo, E, Manfredi, M, Chiariello, C, Conte, E, Castagna, A, Robotti, E, Gosetti, F, Mazzucco, E, Martinelli, N, Cecconi, D, Olivieri, O, and Marengo, E

Subjects
CHIM/01 - CHIMICA ANALITICA, plasma proteome, APO CIII, high-resolution MS, swath MS
Published
2018

259. Characterization of the modification in mitochondrial proteome due to eIF6 depletion by SWATH-MS analysis and multivariate statistical tools

Author

Robotti, E, Martinotti, S, Manfredi, M, Conte, E, Scagliola, A, Calamita, P, Gosetti, F, Marengo, E, Ranzato, E, Biffo, S, Robotti, E, Martinotti, S, Manfredi, M, Conte, E, Scagliola, A, Calamita, P, Gosetti, F, Marengo, E, Ranzato, E, and Biffo, S

Subjects
CHIM/01 - CHIMICA ANALITICA, mitochondrial proteome, eIF6, SWATH-MS, multivariate analysis, chemometrics
Published
2018

263. Erratum to: tDCS application over the STG improves the ability to recognize and appreciate elements involved in humor processing (Experimental Brain Research, (2017), 235, 6, (1843-1852), 10.1007/s00221-017-4932-5)

Author

Manfredi M., Manfredi, M, Proverbio, A, Donate, A, Vieira, S, Comfort, W, De Araujo Andreoli, M, Boggio, P, Manfredi M., Proverbio A. M., Donate A. P. G., Vieira S. M. G., Comfort W. E., De Araujo Andreoli M., Boggio P. S., Manfredi M., Manfredi, M, Proverbio, A, Donate, A, Vieira, S, Comfort, W, De Araujo Andreoli, M, Boggio, P, Manfredi M., Proverbio A. M., Donate A. P. G., Vieira S. M. G., Comfort W. E., De Araujo Andreoli M., and Boggio P. S.

Abstract

The original version of this article contained an error in two references (listed below) for Bonda et al. (1996). Bonda E, Ostry D, Evans A (1996a) Specific involvement of human parietal systems in the perception of biological motion and the amygdala. J Neurosci 76(11):3737-3744 Bonda E, Petrides M, Ostry D, Evans A (1996b) Specific involvement of human parietal systems and the amygdala in the perception of biological motion. J Neurosci 16:3737-3744 They should be deleted and substituted with just one paper whose the correct reference is: Bonda E, Petrides M, Ostry D, Evans A (1996) Specific involvement of human parietal systems and the amygdala in the perception of biological motion. J Neurosci 16(11):3737-3744.

Published
2017

269. SHiP Experiment - Progress Report

Author

Ahdida, C, Albanese, R, Alexandrov, A, Anokhina, A, Aoki, S, Arduini, G, Atkin, E, Azorskiy, N, Back, J J, Bagulya, A, Baaltasar Dos Santos, F, Baranov, A, Bardou, F, Barker, G J, Battistin, M, Bauche, J, Bay, A, Bayliss, V, Bencivenni, G, Berdnikov, A Y, Berdnikov, Y A, Berezkina, I, Bertani, M, Betancourt, C, Bezshyiko, I, Bezshyyko, O, Bick, D, Bieschke, S, Blanco, A, Boehm, J, Bogomilov, M, Bondarenko, K, Bonivento, W M, Borburgh, J, Boyarsky, A, Brenner, R, Breton, D, Brundler, R, Bruschi, M, Buscher, V, Buonaura, A, Buontempo, S, Cadeddu, S, Calcaterra, A, Calviani, M, Campanelli, M, Casolino, M, Charitonidis, N, Chau, P, Chauveau, J, Chepurnov, A, Chernyavskiy, M, Choi, K -Y, Chumakov, A, Ciambrone, P, Cornelis, K, Cristinziani, M, Crupano, A, Dallavalle, G M, Datwyler, A, D'Ambrosio, N, D'Appollonio, G, De Carvalho Saraiva, J, De Lellis, G, de Magistris, M, De Roeck, A, De Serio, M, De Simone, D, Dedenko, L, Dergachev, P, Di Crescenzo, A, Di Marco, N, Dib, C, Dijkstra, H, Dipinto, P, Dmitrenko, V, Dmitrievskiy, S, Dougherty, L A, Dolmatov, A, Domenici, D, Donskov, S, Drohan, V, Dubreuil, A, Ebert, J, Ehlert, M, Enik, T, Etenko, A, Fabbri, F, Fabbri, L, Fabich, A, Fedin, O, Fedotovs, F, Felici, G, Ferro-Luzzi, M, Filippov, K, Fini, R A, Fonte, P, Franco, C, Fraser, M, Fresa, R, Froeschl, R, Fukuda, T, Galati, G, Gall, J, Gatignon, L, Gavrilov, G, Gentile, V, Gerlach, S, Goddard, B, Golinka-Bezshyyko, L, Golovatiuk, A, Golubkov, D, Golutvin, A, Gorbounov, P, Gorbunov, D, Gorbunov, S, Gorkavenko, V, Gornushkin, Y, Gorshenkov, M, Grachev, V, Grandchamp, A L, Granich, G, Graverini, E, Grenard, J -L, Grenier, D, Grichine, V, Gruzinskii, N, M Guler, A, Guz, Yu, Haefeli, G J, Hagner, C, Hakobyan, H, Harris, I W, van Herwijnen, E, Hessler, C, Hollnagel, A, Hosseini, B, Hushchyn, M, Iaselli, G, Iuliano, A, Ivantchenko, V, Jacobsson, R, Jokovic, D, Jonker, M, Kadenko, I, Kain, V, Kamiscioglu, C, Kershaw, K, Khabibullin, M, Khalikov, E, Khaustov, G, Khoriauli, G, Khotyantsev, A, Kim, S H, Kim, Y G, Kim, V, Kitagawa, N, Ko, -W, Kodama, K, Kolesnikov, A, Kolev, D I, Kolosov, V, Komatsu, M, Kondrateva, N, Kono, A, Konovalova, N, Kormannshaus, S, Korol, I, Korolko, I, Korzenev, A, Kostyukhin, V, Koukovini Platia, E, Kovalenko, S, Krasilnikova, I, Kudenko, Y, Kurbatov, E, Kurbatov, P, Kurochka, V, Kuznetsova, E, Lacker, H M, Lamont, M, Lanfranchi, G, Lantwin, O, Lauria, A, Lee, K S, Lee, K Y, Levy, J-M, Loschiavo, V P, Lopes, L, Lopez Sola, E, Lyubovitskij, V, Maalmi, J, Magnan, A, Maleev, V, Malinin, A, Manabe, Y, Managadze, A K, Manfredi, M, Marsh, S, Marshall, A M, Mefodev, A, Mermod, P, Miano, A, Mikado, S, Mikhaylov, Yu, Milstead, D A, Mineev, O, Montanari, A, Montesi, M C, Morishima, K, Movchan, S, Muttoni, Y, Naganawa, N, Nakamura, M, Nakano, T, Nasybulin, S, Ninin, P, Nishio, A, Novikov, A, Obinyakov, B, Ogawa, S, Okateva, N, Opitz, B, Osborne, J, Ovchynnikov, M, Owtscharenko, N, Owen, P H, Pacholek, P, Paoloni, A, Paparella, R, Park, B D, Park, S K, Pastore, A, Patel, M, Pereyma, D, Perillo-Marcone, A, Petkov, G L, Petridis, K, Petrov, A, Podgrudkov, D, Poliakov, V, Polukhina, N, Prieto Prieto, J, Prokudin, M, Prota, A, Quercia, A, Rademakers, A, Rakai, A, Ratnikov, F, Rawlings, T, Redi, F, Ricciardi, S, Rinaldesi, M, Rodin, Volodymyr, Rodin, Viktor, Robbe, P, Rodrigues Cavalcante, A B, Roganova, T, Rokujo, H, Rosa, G, Rovelli, T, Ruchayskiy, O, Ruf, T, Samoylenko, V, Samsonov, V, Sanchez Galan, F, Santos Diaz, P, Sanz Ull, A, Saputi, A, Sato, O, Savchenko, E S, Schliwinski, J S, Schmidt-Parzefall, W, Serra, N, Sgobba, S, Shadura, O, Shakin, A, Shaposhnikov, M, Shatalov, P, Shchedrina, T, Shchutska, L, Shevchenko, V, Shibuya, H, Shihora, M, Shirobokov, S, Shustov, A, Silverstein, S B, Simone, S, Simoniello, R, Skorokhvatov, M, Smirnov, S, Sohn, J Y, Sokolenko, A, Solodko, E, Starkov, N, Stoel, L, Storaci, B, Stramaglia, M E, Sukhonos, D, Suzuki, Y, Takahashi, S, Tastet, J L, Teterin, P, Than Naing, S, Timiryasov, I, Tioukov, V, Tommasini, D, Torii, M, Tosi, N, Treille, D, Tsenov, R, Ulin, S, Ustyuzhanin, A, Uteshev, Z, Vankova-Kirilova, G, Vannucci, F, Venkova, P, Venturi, V, Vilchinski, S, Villa, M, Vincke, Heinz, Vincke, Helmut, Visone, C, Vlasik, K, Volkov, A, Voronkov, R, van Waasen, S, Wanke, R, Wertelaers, P, Woo, J -K, Wurm, M, Xella, S, Yilmaz, D, Yilmazer, A U, Yoon, C S, Zarubin, P, Zarubina, I, and Zaytsev, Yu

Subjects
Detectors and Experimental Techniques
Abstract

Progress on the SHiP experiment and the Comprehensive Design Study (CDS) is presented with focus on the re-optimization, the simulation studies and the detector developments, including beam tests since the Technical Proposal, and the physics performance. This document is complementing the proposal submitted to the update of the European Strategy for Particle Physics (ESPPU).

Published
2019

270. An efficient MRI agent targeting extracellular markers in prostate adenocarcinoma

Author

Pagoto, A., Tripepi, M., Stefania, R., Lanzardo, S., Livio Longo, D., Garello, F., Porpiglia, F., Manfredi, M., Aime, S., Terreno, E., and Longo, Dario Livio

Subjects
Male, Gadolinium, Contrast Media, Peptide, weighted MRI, Acetates, 030218 nuclear medicine & medical imaging, Mice, Prostate cancer, 0302 clinical medicine, Nuclear magnetic resonance, Prostate, T-1-weighted MRI, chemistry.chemical_classification, Azepines, prostate cancer, Magnetic Resonance Imaging, medicine.anatomical_structure, Protein Binding, Spectrometry, Mass, Electrospray Ionization, Relaxometry, Mice, Nude, chemistry.chemical_element, Adenocarcinoma, 03 medical and health sciences, fibrin-fibronectin complex, In vivo, Cell Line, Tumor, Biomarkers, Tumor, Extracellular, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, AAZTA, fibrin–fibronectin complex, T, 1, targeting peptide, Fibrin, Prostatic Neoplasms, medicine.disease, In vitro, Fibronectins, chemistry, Peptides, Neoplasm Transplantation, 030217 neurology & neurosurgery
Abstract

Purpose Prostate cancer (PCa) is the most widespread tumor affecting males in Western countries. We propose a novel MRI molecular tetrameric probe based on the heptadentate gadolinium (Gd)-AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) that is able to in vivo detect PCa through the recognition of the fibrin-fibronectin (FB-FN) complex. Methods The peptide CREKA (Cys-Arg-Glu-Lys-Ala), targeting the FB-FN complex in the reactive stroma of the tumor, was synthesized by solid phase peptide synthesis (SPPS) and conjugated to the tetramer dL-(Gd-AAZTA)4 . The resulting probe was characterized by 1 H relaxometry, tested in vitro on FB clots and in vivo on an orthotopic mouse model of PCa. Results CREKA-dL-(Gd-AAZTA)4 showed a remarkable relaxivity of 18.2 m M Gd - 1 s-1 (0.47 T, 25°C) because of the presence of 2 water molecules (q = 2) in the inner coordination sphere of each Gd3+ ion, whose rotational motion (τR ) is lengthened as the result of the relatively high molecular weight. The probe displayed a detectable affinity for plasma-derived FB clots. On intravenous injection of the probe in an orthotopic mouse model of PCa, a significant increase in the prostate T1 contrast (~40%) was observed. The MRI signal appears statistically higher either with respect to the one observed for the control probes and to the one detected when CREKA-dL-(Gd-AAZTA)4 was administered to healthy animals. Conclusions This study demonstrated the ability of the CREKA-dL-(Gd-AAZTA)4 probe to specifically localize in prostate tumor after injection. The high relaxivity of the probe allows the reduction of the injected dose to 20 µmolGd /kg, yielding a good in vivo contrast enhancement in the region of prostate tumor.

Published
2019

271. A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: a pilot study

Author

Infantino, M., Carbone, T., Manfredi, M., Grossi, V., Antico, A., Panozzo, M. P., Brusca, I., Alessio, M. G., Previtali, G., Platzgummer, S., Cinquanta, L., Paura, G., Deleonardi, G., Trevisan, M. T., Radice, A., Castiglione, C., Imbastaro, T., Fabris, M., Pesce, G., brunetta porcelli, Terzuoli, L., Sorrentino, M. C., Tampoia, M., Villalta, D., Conte, M., Barberio, G., Gallo, N., Benucci, M., and Bizzaro, N.

Published
2019

272. Effect of different types of roasting on hazelnut immunoreactivity

Author

Lamberti C.(1), Nebbia S.(1), Cirrincione S. (1), Antoniazzi S.(1), Manfredi M.(2), Marengo E.(2), Giuffrida M.G.(1), and Cavallarin L. (1)

Subjects
food allergy, hazelnut, processing
Abstract

Introduction: It is known that thermal processing, commonly used during food production, may affect food allergenicity by inducing physical and/or chemical changes in macronutrients. However, due to the lack of detailed information on processing procedures, available evidences on this topic are presently contradictory. This study aims to evaluate the effects of different types of roasting on hazelnut protein solubility and immune reactivity. Methods: We investigated the IgE-binding capacities of both soluble and insoluble hazelnut protein fractions from C. avellana (Cv. Tonda Gentile delle Langhe), before and after roasting using two different roasting techniques: hot air (HA) as a ''traditional method," and infrared (IR), as an ''innovative method". Two combinations of time and temperature for each oven were considered: 140°C for 25min (LT) and 170°C for 17 min (HT) in HA; 140°C for 12 min (LT) and 170°C for 10 min (HT) in IR. Total protein and oil body associated protein extracts were used for immunoblotting experiments with allergic patient sera. Results: A decrease in hazelnut protein solubility was detectable following LT-IR roasting and it became more evident after HT processing, for both roasting types. Concerning allergenicity, the raw hazelnut proteins extract was the most immune reactive, followed by LT-HA and LT-IR processed hazelnut that showed a very similar immune reactive pattern. The HA-HT treatment resulted in a low, although detectable, immune reactivity, while the IR-HT processing caused a quite complete disappearance of immune reactivity of hazelnut proteins. The different hazelnut allergens (Cor a 8, 9, 11, 12, 13, 14, 15) were differently affected by thermal treatments, in accordance with their thermal stability, as already reported by literature. Discussion: HA oven is the most conservative processing, especially at low temperatures, both considering protein solubility and immune-reactivity. Both the HT treatments demonstrated to reduce immune-recognition of hazelnut proteins by allergic patient sera.

Published
2019

273. Effect of thermal processing on the immune cross-reactivity of five edible insects

Author

Cirrincione S. (1), Nebbia S. (1), Lamberti C. (1), Bufo A. (1), Giorgis V. (2), Manfredi M. (3), Marengo E. (3), Giuffrida M.G. (1), Rolla G. (2), and Cavallarin L. (1)

Subjects
food allergy, edible insect, cross-reactivity, fungi, LC-MS/MS
Abstract

Introduction. Edible insects are currently being evaluated as an alternative and sustainable protein source for humans in order to meet the nutritional needs of the growing world population. Specific risk assessment for edible insects is necessary in Europe, where the consumption of insects is an emerging practice. The allergenic potential associated to entomophagy has to be investigated since the introduction of this new food source can cause IgE-mediated cross reactions in patients allergic to crustaceans and mites, that belong to the same phylum of insect. Methods. Five edible insects were investigated: buffalo worm (Alphitobius diaperinus), mealworm (Tenebrio molitor), silkworm (Bombyx mori); cricket (Gryllodes sigillatus) and grasshopper (Locusta migratoria). The soluble and insoluble proteins were extracted from raw and processed (boiled and fried) insects and the protein profiles were analyzed by SDS-PAGE. The IgE cross-reactivity of shrimp (n=8) and house dust mite (n=28) Italian allergic patients were investigated by immunoblotting followed by LC-MS/MS analysis for immune-reactive proteins identification. Results. Buffulo worm, mealworm and cricket showed similar protein profiles for raw and boiled extract, while grasshopper and silkworm differed for both processing methods. For all insects, proteins aggregation increased with increasing processing temperatures, causing an enrichment of the insoluble protein fraction. Preliminary results on the immune-recognition of insect proteins by the sera IgEs of patient allergic to shrimp and mites indicate that the major allergens of shrimp and house dust mite, such as tropomyosin and arginine kinase, are cross-reactive in insects. Furthermore, both processing methods show to affect protein reactivity in an insect-dependent manner. Discussion. The evidence of cross-reactivity of IgEs from patients allergic to shrimp and house dust mite towards differently processed edible insect protein extracts confirms the issue of possible risk associated to insects consuming.

Published
2019

280. European Polistes venom allergy

Author

Severino, M. G., Campi, P., Macchia, D., Manfredi, M., Turillazzi, S., Spadolini, I., Bilò, M. B., and Bonifazi, F.

Published
2006

290. PE35 - A new technology to optimize selective clamping during 3D guided robotic partial nephrectomy: Is it feasible to precisely establish the perfusion areas of the organ?

Author

Amparore, D., Piramide, F., Checcucci, E., De Cillis, S., Piana, A., Volpi, G., Sica, M., Verri, P., Granato, S., Burgio, M., Ola, L., Zamengo, D., Della Corte, M., Busacca, G., Colombo, M., Mandaletti, M., Cossu, M., Mesterca, A.G., Manfredi, M., Fiori, C., and Porpiglia, F.

Published
2022
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292. PE13 - Identify patients candidate for extended pelvic lymph- node dissection during radical prostatectomy based on target biopsy findings only: Internal validation of novel nomogram

Author

Fiori, C., Checcucci, E., Stura, I., De Cillis, S., Amparore, D., Piramide, F., Piana, A., Volpi, G., Granato, S., Verri, P., Sica, M., Piscitello, S., Ola, L., Meziere, J., Zamengo, D., Cisero, E., Della Corte, M., Manfredi, M., Giuseppe, M., and Porpiglia, F.

Published
2022
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296. SC237 - Results from our prospective comparative and functional analysis after different ablative techniques for MRI/real-time ultrasound image fusion guided high intensity focused ultrasound (HIFU)

Author

Piramide, F., De Luca, S., Checcucci, E., Amparore, D., Volpi, G., De Cillis, S., Piana, A., Verri, P., Piscitello, S., Zamengo, D., Meziere, J., Busacca, G., Colombo, M., Pini, F., Sterrantino, A., Ortenzi, M., Giordano, A., Manfredi, M., Fiori, C., and Porpiglia, F.

Published
2022
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299. SC173 - Standard prostate biopsy combined with target biopsy in biopsy naïve patients: does it has an additional role when compared with radical prostatectomy specimens? results of a prospective randomized clinical trial

Author

Checcucci, E., Alladio, E., Manfredi, M., Amparore, D., De Cillis, S., Piramide, F., Volpi, G., Piana, A., Sica, M., Verri, P., Piscitello, S., Ola, L., Zamengo, D., Cisero, E., Della Corte, M., Pini, F., Giordano, A., Fiori, C., De Luca, S., and Porpiglia, F.

Published
2022
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300. SC177 - 3D virtual models assistance predicts higher rates of “successful” minimally-invasive partial nephrectomy: an institutional analysis across the available trifecta definitions

Author

Pecoraro, A., Amparore, D., Piramide, F., Verri, P., Checcucci, E., De Cillis, S., Piana, A., Sica, M., Piscitello, S., Burgio, M., Meziere, J., Zamengo, D., Quarà, A., Della Corte, M., Busacca, G., Colombo, M., Mandaletti, M., Manfredi, M., Fiori, C., and Porpiglia, F.

Published
2022
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