10,040 results on '"Maione, A."'
Search Results
252. Preface and Abstracts of the 2nd International One Health Conference
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Ferrante, Margherita, primary, Oliveri Conti, Gea, additional, Vito, Domenico, additional, Fernandez, Gabriela, additional, Maione, Carol, additional, Lauriola, Paolo, additional, Piscitelli, Prisco, additional, Jimenez Gomes Tagle, Melissa, additional, Dora, Carlos, additional, Serrano Pons, Jordi, additional, Conforti, Carole, additional, Panisello, Joima, additional, Sol Ventura, Paula, additional, Bernotti, Ilaria, additional, Ruiz Martin, Carmen, additional, Buloz, Edgar, additional, Trombetta, Marcella, additional, Banfi, Giuseppe, additional, and Tageo, Valentina, additional
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- 2024
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253. A rare case of simultaneous occurrence of non-arteritic anterior ischemic optic neuropathy and corpus callosum ischemia
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Fossataro, Federica, primary, Pece, Alfredo, additional, Maione, Giulio, additional, Zur, Dinah, additional, and Loewestein, Anat, additional
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- 2024
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254. Influence of regression, its extent and tumor-infiltrating lymphocytes on sentinel node status, relapse, and survival in a 10-year retrospective study of melanoma patients
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Maione, Vincenzo, primary, Perantoni, Martina, additional, Bettolini, Luca, additional, Bighetti, Stefano, additional, Arisi, Mariachiara, additional, Tomasi, Cesare, additional, Incardona, Paolo, additional, and Calzavara-Pinton, Piergiacomo, additional
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- 2024
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255. To score or not to score
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Frola, Edoardo, primary, Mortola, Lorenzo, additional, Mariani, Erica, additional, Scovazzi, Paolo, additional, Maione, Massimo, additional, and Barili, Fabio, additional
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- 2024
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256. SGLT2 Inhibitors in Patients with Advanced Heart Failure Awaiting Heart Transplant: Preliminary Results from The SGLT2i-HT Study
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Gallone, G., primary, Pidello, S., additional, Bertarelli, E., additional, Tedeschi, A., additional, Maione, D., additional, Cacioli, G., additional, Pradegan, N., additional, Tessari, C., additional, Di Nora, C., additional, Verde, A., additional, Perna, E., additional, Raineri, C., additional, Marro, M., additional, Simonato, E., additional, Breviario, F., additional, Cavallier, F., additional, Amarelli, C., additional, Turco, A., additional, Vendramin, I., additional, Gerosa, G., additional, Scelsi, L., additional, Lilla Della Monica, P., additional, Sinagra, G., additional, Garascia, A., additional, Merlo, M., additional, Rinaldi, M., additional, De Ferrari, G.M., additional, and Boffini, M., additional
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- 2024
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257. Non-Integer Order Control of PMSM Drives with Two Nested Feedback Loops
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Lino, Paolo, Maione, Guido, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Malinowska, Agnieszka B., editor, Mozyrska, Dorota, editor, and Sajewski, Łukasz, editor
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- 2020
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258. Urban Metabolism and Minority Pulse: An Education and Awareness Campaign Targeting Minority Groups
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Fernandez, Gabriela, Maione, Carol, Nhamo, Godwell, editor, and Mjimba, Vuyo, editor
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- 2020
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259. Navy Warship Selection and Multicriteria Analysis: The THOR Method Supporting Decision Making
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Tenório, Fabricio Maione, dos Santos, Marcos, Gomes, Carlos Francisco Simões, Araujo, Jean de Carvalho, Thomé, Antônio Márcio Tavares, editor, Barbastefano, Rafael Garcia, editor, Scavarda, Luiz Felipe, editor, dos Reis, João Carlos Gonçalves, editor, and Amorim, Marlene Paula Castro, editor
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- 2020
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260. Imaging Analysis of Patella Instability Factors
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Berruto, Massimo, Ferrua, Paolo, Tradati, Daniele, Maione, Alessio, Usellini, Eva, Dejour, David, editor, Zaffagnini, Stefano, editor, Arendt, Elizabeth A., editor, Sillanpää, Petri, editor, and Dirisamer, Florian, editor
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- 2020
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261. The Use of Fat Grafting for Chronic Headache of Cervical Origin Treatment
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Klinger, Marco, Maione, Luca, Klinger, Francesco, Giannasi, Silvia, and Raposio, Edoardo, editor
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- 2020
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262. Management of Retro-Odontoid Pseudotumor
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Barbagallo, Giuseppe M. V., Maione, Massimiliano, Certo, Francesco, Tessitore, Enrico, editor, Dehdashti, Amir R., editor, Schonauer, Claudio, editor, and Thomé, Claudius, editor
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- 2020
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263. Surgical Decision-Making in Cranio-Vertebral Junction Trauma: A Case Illustrated Chapter
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Schonauer, Claudio, Tessitore, Enrico, de Falco, Raffaele, Maione, Massimiliano, Certo, Francesco, Barbagallo, Giuseppe, Tessitore, Enrico, editor, Dehdashti, Amir R., editor, Schonauer, Claudio, editor, and Thomé, Claudius, editor
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- 2020
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264. The Role of Indocyanine Near-Infrared Fluorescence in Colorectal Surgery
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Francesco Maione, Michele Manigrasso, Alessia Chini, Sara Vertaldi, Pietro Anoldo, Anna D’Amore, Alessandra Marello, Carmen Sorrentino, Grazia Cantore, Rosa Maione, Nicola Gennarelli, Salvatore D’Angelo, Nicola D’Alesio, Giuseppe De Simone, Giuseppe Servillo, Marco Milone, and Giovanni Domenico De Palma
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indocyanine green ,colorectal cancer ,perfusion ,minimally invasive surgery ,nearinfrared fluorescence ,Surgery ,RD1-811 - Abstract
PurposesThe aim of this study was to evaluate the importance of Indocyanine Green in control of anastomosis perfusion and on anastomotic leakage rates during laparoscopic and robotic colorectal procedures.MethodsA retrospective review of patients who underwent elective minimally invasive surgery for colorectal cancer from 1 January 2018 to 31 December 2020 was performed. All patients underwent Near-Infrared Fluorescence-Indocyanine Green system in two moments: before performing the anastomosis and after completing the anastomotic procedure. Primary outcomes were the rate of intraoperative change in the surgical resection due to an inadequate vascularization and the rate of postoperative anastomotic leakage. Secondary outcomes were the postoperative complications, both medical and surgical (intra-abdominal bleeding, anastomotic leakage).ResultsOur analysis included 93 patients. Visible fluorescence was detected in 100% of the cases. In 7 patients (7.5%), the planned site of resection was changed due to inadequate perfusion. The mean extension of the surgical resection in these 7 patients was 2.2 ± 0.62. Anastomotic leakage occurred in 2 patients (2.1%). Other complications included 8 postoperative bleedings (8.6%) and 1 pulmonary thromboembolism.ConclusionsThe intraoperative use of Near-Infrared Fluorescence-Indocyanine Green in colorectal surgery is safe, feasible, and associated with a substantial reduction in postoperative anastomotic leakage rate.
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- 2022
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265. La questione meridionale e la figura di Don Luigi Sturzo a 150 anni dalla nascita
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Raffaele Maione
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Jurisprudence. Philosophy and theory of law ,K201-487 ,Political theory ,JC11-607 - Abstract
The contribution offers a reflection on the ‘southern question’ through the thought of Luigi Sturzo, founder of the Italian Popular Party. A ‘question’ still relevant today that should be framed not only in the space of autonomy and regionalism but also through the reading of the human person, his rights and dignity as a place of participation in economic, political and social life.
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- 2021
266. ‘Collected’ Pages for the Issipile (Teatro San Carlo, 1763)
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Maione Paologiovanni
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issipile ,pasquale cafaro ,metastasio ,naples ,caterina gabrielli ,Musical instruction and study ,MT1-960 - Abstract
During the 1763–64 season, numerous intersections and connections occur behind the scenes of the principal Neapolitan opera house of Teatro di San Carlo. On the one hand, the focus on Metastasian repertoire persists without interruptions – a long and boundless tradition which will only fade towards the end of the century; on the other hand, Hasse’s world still exerts its fascination.
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- 2021
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267. VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
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Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, and Lorenzo Di Cesare Mannelli
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VEGF-A ,VEGFR-1 ,Neuropathy biomarker ,Astrocytes ,D16F7 mAb ,Oxaliplatin ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Neuropathic pain is a clinically relevant adverse effect of several anticancer drugs that markedly impairs patients’ quality of life and frequently leads to dose reduction or therapy discontinuation. The poor knowledge about the mechanisms involved in neuropathy development and pain chronicization, and the lack of effective therapies, make treatment of chemotherapy-induced neuropathic pain an unmet medical need. In this context, the vascular endothelial growth factor A (VEGF-A) has emerged as a candidate neuropathy hallmark and its decrease has been related to pain relief. In the present study, we have investigated the role of VEGF-A and its receptors, VEGFR-1 and VEGFR-2, in pain signalling and in chemotherapy-induced neuropathy establishment as well as the therapeutic potential of receptor blockade in the management of pain. Methods Behavioural and electrophysiological analyses were performed in an in vivo murine model, by using selective receptor agonists, blocking monoclonal antibodies or siRNA-mediated silencing of VEGF-A and VEGFRs. Expression of VEGF-A and VEGFR-1 in astrocytes and neurons was detected by immunofluorescence staining and confocal microscopy analysis. Results In mice, the intrathecal infusion of VEGF-A (VEGF165 isoforms) induced a dose-dependent noxious hypersensitivity and this effect was mediated by VEGFR-1. Consistently, electrophysiological studies indicated that VEGF-A strongly stimulated the spinal nociceptive neurons activity through VEGFR-1. In the dorsal horn of the spinal cord of animals affected by oxaliplatin-induced neuropathy, VEGF-A expression was increased in astrocytes while VEGFR-1 was mainly detected in neurons, suggesting a VEGF-A/VEGFR-1-mediated astrocyte-neuron cross-talk in neuropathic pain pathophysiology. Accordingly, the selective knockdown of astrocytic VEGF-A by intraspinal injection of shRNAmir blocked the development of oxaliplatin-induced neuropathic hyperalgesia and allodynia. Interestingly, both intrathecal and systemic administration of the novel anti-VEGFR-1 monoclonal antibody D16F7, endowed with anti-angiogenic and antitumor properties, reverted oxaliplatin-induced neuropathic pain. Besides, D16F7 effectively relieved hypersensitivity induced by other neurotoxic chemotherapeutic agents, such as paclitaxel and vincristine. Conclusions These data strongly support the role of the VEGF-A/VEGFR-1 system in mediating chemotherapy-induced neuropathic pain at the central nervous system level. Thus, treatment with the anti-VEGFR-1 mAb D16F7, besides exerting antitumor activity, might result in the additional advantage of attenuating neuropathic pain when combined with neurotoxic anticancer agents.
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- 2021
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268. Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice
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Nicola Forte, Serena Boccella, Lea Tunisi, Alba Clara Fernández-Rilo, Roberta Imperatore, Fabio Arturo Iannotti, Maria De Risi, Monica Iannotta, Fabiana Piscitelli, Raffaele Capasso, Paolo De Girolamo, Elvira De Leonibus, Sabatino Maione, Vincenzo Di Marzo, and Luigia Cristino
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Science - Abstract
The authors show that adult hippocampal neurogenesis is altered in the dentate gyrus of obese mice with subsequent inhibition of long-term potentiation and impairment of pattern separation. Inhibition of orexin-A action at orexin-1 receptors rescued both impairments in obese mice.
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- 2021
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269. Mechanical support concept of the DEMO breeding blanket
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Bachmann, C., Gliss, C., Härtl, T., Hernandez, F., Maione, I., Steinbacher, T., and Vizvary, Z.
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- 2021
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270. MHD flow in liquid metal blankets: Major design issues, MHD guidelines and numerical analysis
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Mistrangelo, C., Bühler, L., Smolentsev, S., Klüber, V., Maione, I., and Aubert, J.
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- 2021
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271. Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways
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Potenza, Marianna, Sciarretta, Martina, Chini, Maria Giovanna, Saviano, Anella, Maione, Francesco, D'Auria, Maria Valeria, De Marino, Simona, Giordano, Assunta, Hofstetter, Robert Klaus, Festa, Carmen, Werz, Oliver, and Bifulco, Giuseppe
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- 2021
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272. Pentadecanoic acid against Candida albicans-Klebsiella pneumoniae biofilm: towards the development of an anti-biofilm coating to prevent polymicrobial infections
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Galdiero, E., Ricciardelli, A., D'Angelo, C., de Alteriis, E., Maione, A., Albarano, L., Casillo, A., Corsaro, M.M., Tutino, M.L., and Parrilli, E.
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- 2021
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273. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, McMillan, H, Moss, J, Pugliese, MJ, Richards, T, Seow, YTN, Thian, A, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Huang, L, Lam, YH, Nathan, A, Ong, BS, Ooi, E, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Hui, N, Izwan, S, Jeyarajan, E, Jordan, S, Liang, R, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Sommerville, C, Townend, P, Von Papen, M, Wullschleger, M, Dawson, AC, Drane, A, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Gerns, N, McGeorge, S, Riddell, A, Roberts, M, Rukin, N, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Sheahan, G, Swinson, B, Waldron, A, Walker, P, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Wright, G, Lun, EWY, Lanner, M, Burtscher, J, Trivik-Barrientos, F, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Holawe, S, Zimmermann, M, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St. John, S, Walkes, K, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Ceelen, W, Pattyn, P, Van de putte, D, Van Nieuwenhove, Y, Van Ramshorst, G, Willaert, W, Bazzett-Matabele, L, Chiyapo, SP, Ramogola-Masire, D, Ramontshonyana, G, Seiphetlheng, A, Vuylsteke, P, Abdallah, EA, Aguiar Júnior, S, Baiocchi, G, Carvalho, GB, Coimbra, FJF, Kowalski, LP, Makdissi, F, Marques, N, Marques, T, Soares Dos Santos, S, Tirapelli Gonçalves, B, Vartanian, JG, Dos Reis, R, Camara, P, De Lima, RK, Della Giustina, E, Hoffmann, PV, Gatti, A, Nardi, C, Oliva, R, Nacif, L, Carvalho Ferro, C, Gomes Mendonça Ataíde, G, Lima Buarque, I, Lira dos Santos Leite, A, Pol-Fachin, L, Santos Bezerra, T, Maylson Ramos da Silva, A, Windson de Araújo Silvestre, D, Vieira Barros, A, Campbell, L, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, FR, Terra, RM, Faccini Teixeira, M, Kulcsar, MAV, Matos, LL, Nunes, KS, Laporte, G, Salem, M, Barakat Awada, J, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Nunes, R, Bodanese, B, Eidt, ER, Isoton, JC, Lemos Vieira da Cunha, M, Regina de Sampaio, L, Vendrame, C, Zeni, M, Zortéa, JA, Zortéa, MR, Sokolov, M, Kidane, B, Srinathan, S, Munro, A, Helyer, L, McKeen, D, Boutros, M, Caminsky, NG, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Cheng, D, MacNeil, SD, Martin, J, Dumitra, S, Kouyoumdjian, A, Schmid, S, Spicer, J, Agarwal, A, Brar, A, Dada, J, Dare, A, Hameed, U, Osman, F, Johnston, B, Russell, C, Groot, G, Persad, A, Pham, H, Wood, M, Ko, M, Rajendran, L, Demyttenaere, S, Garfinkle, R, Brown, C, Karimuddin, A, Lee, N, Liu, J, Madani Kia, T, Phang, PT, Raval, M, Tom, K, Abou-Khalil, J, Martel, A, Nessim, C, Stevenson, J, Al Riyami, S, Bali, K, Bigam, D, Dajani, K, Dell, A, Modolo, MM, Ramirez Nieto, P, Sepulveda, R, Molero, A, Bolbaran, A, Ruiz, I, Heredia, F, Bellolio, F, Besser, N, Grasset, E, Guaman, JO, Inzunza, M, Irarrázaval, MJ, Jarry, C, Quintana Martinic, M, Riquoir Altamirano, C, Romero Manqui, CA, Ruiz Esquide, M, Vargas Añazco, C, Almeciga, A, Fletcher, A, Merchan, A, Quijano, T, Sanabria, D, Arias-Amézquita, F, Cétares, C, Cortes Murgueitio, N, Gomez-Mayorga, JL, Herrera-Almario, G, Rodriguez, J, Iglesias, P, 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Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Taylor, M, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, MD, Millward, CP, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, Babar, MS, Bowen, J, Collard, B, Goodrum, S, Lau, K, Sargent, M, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Semple, C, Elhamshary, A, Imam, SMB, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, McEwen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Arumugam, S, Ibrahim, B, Khan, K, Combellack, T, Hill, G, Jones, S, Kornaszewska, M, Mohammed, M, Tahhan, G, Valtzoglou, V, Blencowe, N, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, TA, Main, B, Olivier, J, Newton, C, Roswadowski, S, Ryan, N, Teh, E, West, D, Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, McEvoy, K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, 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Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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274. Interleukin-17A (IL-17A): A silent amplifier of COVID-19
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Maione, Francesco, Casillo, Gian Marco, Raucci, Federica, Salvatore, Cristian, Ambrosini, Giovanna, Costa, Luisa, Scarpa, Raffaele, Caso, Francesco, and Bucci, Mariarosaria
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- 2021
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275. Models of dielectric relaxation based on completely monotone functions
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Garrappa, Roberto, Mainardi, Francesco, and Maione, Guido
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Mathematical Physics ,Condensed Matter - Materials Science ,Condensed Matter - Soft Condensed Matter ,Mathematics - Complex Variables ,26A33, 33E12, 34A08, 26A48, 44A10, 91B74 - Abstract
The relaxation properties of dielectric materials are described, in the frequency domain, according to one of the several models proposed over the years: Kohlrausch-Williams-Watts, Cole-Cole, Cole-Davidson, Havriliak-Negami (with its modified version) and Excess wing model are among the most famous. Their description in the time domain involves some mathematical functions whose knowledge is of fundamental importance for a full understanding of the models. In this work, we survey the main dielectric models and we illustrate the corresponding time-domain functions. In particular, we stress the attention on the completely monotone character of the relaxation and response functions. We also provide a characterization of the models in terms of differential operators of fractional order., Comment: 44 pages, 26 figures
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- 2016
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276. Modeling Mergers of Known Galactic Systems of Binary Neutron Stars
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Feo, Alessandra, De Pietri, Roberto, Maione, Francesco, and Löffler, Frank
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General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology - Abstract
We present a study of the merger of six different known galactic systems of binary neutron stars (BNS) of unequal mass with a mass ratio between $0.75$ and $0.99$. Specifically, these systems are J1756-2251, J0737-3039A, J1906+0746, B1534+12, J0453+1559 and B1913+16. We follow the dynamics of the merger from the late stage of the inspiral process up to $\sim$ 20 ms after the system has merged, either to form a hyper-massive neutron star (NS) or a rotating black hole (BH), using a semi-realistic equation of state (EOS), namely the seven-segment piece-wise polytropic SLy with a thermal component. For the most extreme of these systems ($q=0.75$, J0453+1559), we also investigate the effects of different EOSs: APR4, H4, and MS1. Our numerical simulations are performed using only publicly available open source code such as, the Einstein Toolkit code deployed for the dynamical evolution and the LORENE code for the generation of the initial models. We show results on the gravitational wave signals, spectrogram and frequencies of the BNS after the merger and the BH properties in the two cases in which the system collapse within the simulated time., Comment: 13 pages, 10 figures
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- 2016
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277. Binary neutron star merger simulations with different initial orbital frequency and equation of state
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Maione, Francesco, De Pietri, Roberto, Feo, Alessandra, and Löffler, Frank
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results from three-dimensional general relativistic simulations of binary neutron star coalescences and mergers using public codes. We considered equal mass models where the baryon mass of the two Neutron Stars (NS) is $1.4M_{\odot}$, described by four different equations of state (EOS) for the cold nuclear matter (APR4, SLy, H4, and MS1; all parametrized as piecewise polytropes). We started the simulations from four different initial interbinary distances ($40, 44.3, 50$, and $60$ km), including up to the last 16 orbits before merger. That allows to show the effects on the gravitational wave phase evolution, radiated energy and angular momentum due to: the use of different EOSs, the orbital eccentricity present in the initial data and the initial separation (in the simulation) between the two stars. Our results show that eccentricity has a major role in the discrepancy between numerical and analytical waveforms until the very last few orbits, where "tidal" effects and missing high-order post-Newtonian coefficients also play a significant role. We test different methods for extrapolating the gravitational wave signal extracted at finite radii to null infinity. We show that an effective procedure for integrating the Newman-Penrose $\psi_4$ signal to obtain the gravitational wave strain $h$ is to apply a simple high-pass digital filter to $h$ after a time domain integration, where only the two physical motivated integration constants are introduced. That should be preferred to the more common procedures of introducing additional integration constants, integrating in the frequency domain or filtering $\psi_4$ before integration., Comment: 32 pages, 13 figures
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- 2016
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278. A Cluster Analysis Methodology for the Categorization of Soil Samples for Forensic Sciences Based on Elemental Fingerprint
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Camila Maione, Nattane Luíza da Costa, Fernando Barbosa, and Rommel Melgaço Barbosa
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Electronic computers. Computer science ,QA75.5-76.95 ,Cybernetics ,Q300-390 - Abstract
Soil and dirt fragments are easily transferred from the ground to objects such as clothing, shoes, skin, nails, and tires. The elemental analysis of these samples involved in crimes can be an important source of information for forensic scientists because they can present substantial evidence by creating links between victims, suspects, crime scenes and other relevant actors or places. In this work we present a promising new approach for the study of soil samples, using data mining techniques applied to the elemental fingerprints of soil. We experimented on soil samples obtained from southeast Oregon and northern Nevada, two neighboring states in the United States that have similar geological characteristics while also displaying some specific differences. The chemical composition of soil and sediments samples were determined by the use of inductively coupled plasma-mass spectrometry (ICP-MS). Thirty-three elements were analyzed, and we used their concentrations to conduct the analysis. Cluster analysis was performed employing the K-means clustering algorithm. We found three clusters that showed interesting chemical patterns. In order to investigate the most significant chemical elements that distinguish the clusters, we employed the Correlation-Based Feature Selection (CFS) algorithm. Lastly, we developed a classification model based on support vector machine (SVM), which can predict in which of the found clusters an arbitrary soil sample would fall with a 99% prediction accuracy when all 32 variables were used for training the model, and a 95% prediction accuracy when only the 10 most relevant elements were used for training the model. Following this methodology, forensic scientists and experts would be able to establish profiles of soil samples extracted from the crime scene and nearby regions, and use classification models to predict which of these profiles an arbitrary soil sample found on the subjects involved in the crime would be associated with.
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- 2022
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279. Editorial: Natural products as an emerging therapeutic alternative for the treatment of anxiety and depression, Volume II
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Ajmal Khan, Haroon Khan, Francesco Maione, and Nasiara Karim
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natural products ,depression ,major depressive disorder (DEP) ,monoamine oxidase (MAO) ,herbomics ,Therapeutics. Pharmacology ,RM1-950 - Published
- 2022
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280. Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs
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Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A. Schildberg, Paul A. Gleeson, Birgit M. Reipert, Johannes Oldenburg, and Christian Kurts
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Hematology ,Immunology ,Medicine - Abstract
A major complication of hemophilia A therapy is the development of alloantibodies (inhibitors) that neutralize intravenously administered coagulation factor VIII (FVIII). Immune tolerance induction therapy (ITI) by repetitive FVIII injection can eradicate inhibitors, and thereby reduce morbidity and treatment costs. However, ITI success is difficult to predict and the underlying immunological mechanisms are unknown. Here, we demonstrated that immune tolerance against FVIII under nonhemophilic conditions was maintained by programmed death (PD) ligand 1–expressing (PD-L1–expressing) regulatory T cells (Tregs) that ligated PD-1 on FVIII-specific B cells, causing them to undergo apoptosis. FVIII-deficient mice injected with FVIII lacked such Tregs and developed inhibitors. Using an ITI mouse model, we found that repetitive FVIII injection induced FVIII-specific PD-L1+ Tregs and reengaged removal of inhibitor-forming B cells. We also demonstrated the existence of FVIII-specific Tregs in humans and showed that such Tregs upregulated PD-L1 in patients with hemophilia after successful ITI. Simultaneously, FVIII-specific B cells upregulated PD-1 and became killable by Tregs. In summary, we showed that PD-1–mediated B cell tolerance against FVIII operated in healthy individuals and in patients with hemophilia A without inhibitors, and that ITI reengaged this mechanism. These findings may impact monitoring of ITI success and treatment of patients with hemophilia A.
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- 2022
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281. Survival analyses of the ZeOxaNMulti trial: Follow-up randomized, double-blinded, placebo-controlled trial of oral PMA-zeolite to prevent chemotherapy-induced side effects, especially peripheral neuropathy
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Maria Giuseppa Vitale, Anna Crispo, Dario Arundine, Riccardo Ronga, Carmela Barbato, Assunta Luongo, Francesco Habetswallner, Bernardo Maria De Martino, Angela Maione, Sandra Eisenwagen, Giovanna Vitale, and Ferdinando Riccardi
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oxaliplatin ,PMA-zeolite ,chemotherapy-induced peripheral neuropathy ,colorectal cancer ,disease-free survival ,progression-free survival ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Following the previously published results of the clinical randomized ZeOxaNMulti trial, we evaluated the potential of the tested product PMA-ZEO (Multizeo Med) in the prevention of chemotherapy-induced side effects (especially peripheral neuropathy) within a 30-month follow-up analysis. The aim was to determine the disease-free survival (DFS), progression-free survival (PFS), and overall survival (OS) in a study-population suffering from colorectal cancer that was previously enrolled in the ZeOxaNMulti trial from April 2015 to October 2018. The participants of the study were randomized to receive either PMA-ZEO or placebo while undergoing oxaliplatin-based chemotherapy. A total of 104 patients (pts) (51% of participants randomized to the PMA-ZEO group and 49% to the placebo group), out of a total of 120 pts included in the ZeOxaNMulti trial in 2015, were followed up until March 2021 and were included in the follow-up analysis. According to the chemotherapy line, 44.2% of patients received chemotherapy in an adjuvant setting, and 55.8% of patients received chemotherapy as first-line treatment. The statistical analysis for DFS, PFS, and OS was performed by comparison of the end results with data from the PMA-ZEO/placebo-intervention start point. The analysis of OS did not show statistically significant differences in the first-line chemotherapy patients randomized to PMA-ZEO than among the placebo group (p = 0.1) over the whole period of follow-up (30 months). However, focusing on the PMA-ZEO supplementation time point (7 months), a positive and statistically significant trend (p = 0.004) was documented in the OS analysis for the first-line chemotherapy patients with increasing months of PMA-ZEO treatment compared to the placebo group. Furthermore, borderline statistical significance was reached for PFS at the PMA-ZEO supplementation time point (7 months) in the first-line chemotherapy patients (p = 0.05) for cancer progression events. After stratification of the first-line chemotherapy patients, statistically relevant trends for OS for age, comorbidities, and oxaliplatin dosage (cycles) were also determined. The overall results for DFS (adjuvant patients), PFS (first-line chemotherapy patients), and OS (adjuvant and first-line chemotherapy patients) were generally slightly better in the PMA-ZEO group than in the placebo group, even though no statistically significant results were obtained between the groups within the follow-up period until 2021 (30 months). Based on this follow-up analysis, protective effects of PMA-zeolite supplementation can be deduced. A positive trend and more importantly, significant results in PFS and OS for specific patient groups during and/or after PMA-ZEO treatment were determined, which supports the use of PMA-ZEO as an oncological supportive therapy.
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- 2022
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282. Efficiency of injected anchors in connecting T–shaped masonry walls: a modelling approach
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Maione, A., Casapulla, C., Di Ludovico, M., Prota, A., and Ceroni, F.
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- 2021
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283. Efficacy of short-term antibiotic prophylaxis in immediate two-stage breast reconstruction after mastectomy: A retrospective monocentric study
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Barbera, Federico, Lisa, Andrea, Vinci, Valeriano, Maione, Luca, Veronesi, Alessandra, Giannasi, Silvia, Bandi, Valeria, and Klinger, Francesco
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- 2021
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284. Quantifying plastics waste accumulations on coastal tourism sites in Zanzibar, Tanzania
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Maione, Carol
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- 2021
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285. Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer
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Saviano, Anella, Casillo, Gian Marco, Raucci, Federica, Pernice, Alessia, Santarcangelo, Cristina, Piccolo, Marialuisa, Ferraro, Maria Grazia, Ciccone, Miriam, Sgherbini, Alessandro, Pedretti, Nadia, Bonvicini, Daniele, Irace, Carlo, Daglia, Maria, Mascolo, Nicola, and Maione, Francesco
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- 2021
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286. Quantum Big Bounce of the Isotropic Universe Using Relational Time
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Eleonora Giovannetti, Fabio Maione, and Giovanni Montani
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quantum cosmology ,isotropic Universe ,quantum Big Bounce ,polymer quantum mechanics ,Elementary particle physics ,QC793-793.5 - Abstract
We analyze the canonical quantum dynamics of the isotropic Universe with a metric approach by adopting a self-interacting scalar field as relational time. When the potential term is absent, we are able to associate the expanding and collapsing dynamics of the Universe with the positive- and negative-frequency modes that emerge in the Wheeler–DeWitt equation. On the other side, when the potential term is present, a non-zero transition amplitude from positive- to negative-frequency states arises, as in standard relativistic scattering theory below the particle creation threshold. In particular, we are able to compute the transition probability for an expanding Universe that emerges from a collapsing regime both in the standard quantization procedure and in the polymer formulation. The probability distribution results similar in the two cases, and its maximum takes place when the mean values of the momentum essentially coincide in the in-going and out-going wave packets, as it would take place in a semiclassical Big Bounce dynamics.
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- 2023
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287. Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment
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Francesco Petrillo, Marica Sinoca, Antonio Maria Fea, Marilena Galdiero, Angela Maione, Emilia Galdiero, Marco Guida, and Michele Reibaldi
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fungal ocular infection ,antimicrobial agents ,Candida albicans ,fungal biofilms ,endophtalmitis ,keratitis and ocular candidiasis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Fungi represent a very important cause of microbial eye infections, especially in tropical and developing countries, as they could cause sight-threating disease, such as keratitis and ocular candidiasis, resulting in irreversible vision loss. Candida species are among the most frequent microorganisms associated with fungal infection. Although Candida albicans is still the most frequently detected organism among Candida subspecies, an important increase in non-albicans species has been reported. Mycotic infections often represent an important diagnostic-clinical problem due to the difficulties in performing the diagnosis and a therapeutic problem due to the limited availability of commercial drugs and the difficult penetration of antifungals into ocular tissues. The ability to form biofilms is another feature that makes Candida a dangerous pathogen. In this review, a summary of the state-of-the-art panorama about candida ocular pathology, diagnosis, and treatment has been conducted. Moreover, we also focused on new prospective natural compounds, including nanoparticles, micelles, and nanocarriers, as promising drug delivery systems to better cure ocular fungal and biofilm-related infections. The effect of the drug combination has also been examined from the perspective of increasing efficacy and improving the course of infections caused by Candida which are difficult to fight.
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- 2023
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288. Effect of Escin Alone or in Combination with Antifungal Agents on Resistant Candida glabrata Biofilms: Mechanisms of Action
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Angela Maione, Marianna Imparato, Marilena Galdiero, Elisabetta de Alteriis, Antonia Feola, Emilia Galdiero, and Marco Guida
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biofilm ,Candida glabrata ,azole resistance ,β-escin ,antifungal therapy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Nowadays, the increase in antimicrobial-resistant fungi (AMR) is certainly a major health concern, and the development of alternative therapeutic strategies has become crucial. Natural products have been used to treat various infections, and their chemical properties contribute to the performance of their biological activities, such as antifungal action. The various virulence factors and mechanisms of resistance to antifungals contribute to making Candida glabrata one of the most frequent agents of candidiasis. Here we investigate the in vitro and in vivo activity of β-escin against Candida glabrata. The β-escin MICs were determined for a reference strain and two clinical isolates of C. glabrata. Furthermore, growth kinetics assays and biofilm inhibition/eradication assays (crystal violet) were performed. The differences in the expression of some anti-biofilm-associated genes were analyzed during biofilm inhibition treatment so that reactive oxygen species could be detected. The efficacy of β-escin was evaluated in combination with fluconazole, ketoconazole, and itraconazole. In addition, a Galleria mellonella infection model was used for in vivo treatment assays. Results have shown that β-escin had no toxicity in vitro or in vivo and was able to inhibit or destroy biofilm formation by downregulating some important genes, inducing ROS activity and affecting the membrane integrity of C. glabrata cells. Furthermore, our study suggests that the combination with azoles can have synergistic effects against C. glabrata biofilm. In summary, the discovery of new antifungal drugs against these resistant fungi is crucial and could potentially lead to the development of future treatment strategies.
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- 2023
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289. Contributors
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Abashkin, Andrew Y., primary, Abdelhady, Samar, additional, Abedi, Reem, additional, Agarkova, Darya I., additional, Alam, Hasan, additional, Alexiou, George, additional, Alexiou, Georgios, additional, Alicia, Garzon Heredia, additional, Aloisi, Marta, additional, Ande, Sudharsana Rao, additional, Asehnoune, Karim, additional, Ashekyan, Ohanes, additional, Azicnuda, Eva, additional, Barlow, Karen M., additional, Batson, Carleen, additional, Belal, Eslam, additional, Belardo, Carmela, additional, Biroli, Francesco, additional, Bivona, Umberto, additional, Boccella, Serena, additional, Bouras, Marwan, additional, Bragin, Denis E., additional, Calabrò, Rocco Salvatore, additional, Carabias, C.S., additional, Cattin, Lucia, additional, Chavali, Siddharth, additional, Chui, Helena C., additional, Ciurli, Maria Paola, additional, Claire, Vallat-Azouvi, additional, Contrada, Marianna, additional, Cordoba, Alvaro, additional, de Oliveira, Matheus Fernandes, additional, De Rosa, Silvia, additional, Devarajan, Agilandeswari, additional, Dhote, Vipin V., additional, Dobrzeniecki, Michael, additional, dos Santos, João Gustavo Rocha Peixoto, additional, Eid, Ali, additional, El Dor, Maya, additional, Eriksson, Evert A., additional, Fighera, Michele Rechia, additional, Formisano, Rita, additional, Frache, Bernardina, additional, Froese, Logan, additional, Furian, Ana Flavia, additional, Gasenzer, Elena Romana, additional, Gomez, Alwyn, additional, Gritti, Paolo, additional, Guida, Francesca, additional, Hacioglu, Aysa, additional, Haidar, Muhammad Ali, additional, Hicks, Steven D., additional, Higuchi, Makoto, additional, Huang, Shih-Wei, additional, Iannotta, Monica, additional, Infantino, Rosmara, additional, Irimia, Andrei, additional, Issa, Hawraa, additional, Iyer, Kartik K., additional, Kanat, Ayhan, additional, Kang, Min-Gu, additional, Karaca, Zuleyha, additional, Kelestimur, Fahrettin, additional, Kemp, Michael, additional, Kim, Doo Young, additional, Kim, Eunkyung, additional, Kiragu, Andrew, additional, Kobeissy, Firas H., additional, Kopylov, Artem A., additional, Korolev, Svyatoslav B., additional, Kozo, Hanayama, additional, Lagares, A., additional, Law, E. Meng, additional, Lee, Yu-Hao, additional, Leobas, Gustavo Fernandes, additional, Lima, Gabriel Corrêa, additional, Liou, Tsan-Hon, additional, Luongo, Livio, additional, Maggio, Maria Grazia, additional, Maione, Sabatino, additional, Martynov, Dmitry S., additional, Metaxas, Dimitrios, additional, Mimura, Masaru, additional, MohanMarugaRaja, Muthu Kumaradoss, additional, Mondello, Stefania, additional, Nakae, Ryuta, additional, Nasios, Anastasios, additional, Nasrallah, Leila, additional, Oh, Byung-Mo, additional, Oliveira, M.S., additional, Outani, Oumaima, additional, Paiva, Wellingson Silva, additional, Palazzo, Enza, additional, Patel, Vinood B., additional, Philippe, Allain, additional, Philippe, Azouvi, additional, Preedy, Victor R., additional, Pyun, Sung-Bom, additional, Rajendram, Rajkumar, additional, Rambo, Leonardo Magno, additional, Rapiti, Marta, additional, Rath, Girija Prasad, additional, Reslan, Mohammad Amine, additional, Ricciardi, Flavia, additional, Ricciardi, Luca, additional, Rizos, Dimitrios, additional, Roldan, Jose Maria Dominguez, additional, Roquilly, Antoine, additional, Rostowsky, Kenneth A., additional, Royes, Luiz Fernando Freire, additional, Samir, Yasmine, additional, Scerrati, Alba, additional, Semenova, Zhanna B., additional, Shakkour, Zaynab, additional, Shankar, Jai Jai Shiva, additional, Sheludyakov, Anatoly Y., additional, Silvestro, Daniela, additional, Slusher, Tina, additional, Sönmez, Bedriye Müge, additional, Sorte, Anselmo Alves Boa, additional, Stein, Athena, additional, Tabet, Maha, additional, Tagai, Kenji, additional, Takahata, Keisuke, additional, Takashi, Hiraoka, additional, Thomas, Christopher S., additional, Trofimov, Alexey O., additional, Trofimova, Xenia A., additional, Villalobos, Dolores, additional, Voulgaris, Spyridon, additional, Wakam, Glenn, additional, Wu, Andrew, additional, Ygropoulou, Olga, additional, Yokobori, Shoji, additional, Zangari, Rosalia, additional, Zeiler, Frederick A., additional, and Zibara, Kazem, additional
- Published
- 2022
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290. Protecting Our Oceans with Citizen Science: El Astillero, Nicaragua
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Maione, Carol, primary, Fernandez, Gabriela, additional, Vito, Domenico, additional, Marsaglia, Luca, additional, Cortez, Manuel, additional, and Buurstee, Christan, additional
- Published
- 2022
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291. Optimized Current and Speed Fractional-Order PID Control in Electrical Drives
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Jakovljević, Boris, primary, Lino, Paolo, additional, and Maione, Guido, additional
- Published
- 2022
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292. Cannabidiol in traumatic brain injury
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Palazzo, Enza, primary, Iannotta, Monica, additional, Belardo, Carmela, additional, Infantino, Rosmara, additional, Ricciardi, Flavia, additional, Boccella, Serena, additional, Guida, Francesca, additional, Luongo, Livio, additional, and Maione, Sabatino, additional
- Published
- 2022
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293. Technology usage, intellectual capital, firm performance and employee satisfaction: the accountants' idea
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Torre, Carlo, Tommasetti, Aurelio, and Maione, Gennaro
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- 2021
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294. Medial closure supracondylar femoral osteotomy: an effective solution for long-term treatment of arthritic valgus knee?
- Author
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Francesco Mattia Uboldi, Martino Travi, Daniele Tradati, Alessio Maione, Andrea Fabio Manunta, and Massimo Berruto
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Knee ,Femur ,Valgus ,Osteotomy ,Unicompartmental osteoarthritis ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Purpose The aim of this work was to retrospectively analyze the clinical, subjective, and radiological results of medial closing-wedge distal femur osteotomy (MCW-DFO) for the treatment of osteoarthritis (OA) in valgus knee at medium- to long-term follow-up. Materials and methods A total of 57 patients (62 knees) treated with MCW-DFO between 1984 and 2018 were included in the study. Patient age at the time of the surgery ranged between 28 and 61 years (average: 48 years). All patients with a minimum follow-up of 4 years were contacted to request for them to undergo clinical, subjective, and radiological evaluation. Preoperative hip–knee–ankle (HKA) angle (i.e., preoperative valgus malalignment) was 8.6° ± 2°. Patients were evaluated using the following scales: the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Knee Society Score (KSS), the International Knee Documentation Committee (IKDC), the Visual Analog Scale (VAS), and the Numeric Rating Scale 11 (NRS-11). Results Mean follow-up was 11.6 ± 4.9 years, and a total of 17 patients (20 knees) were available for the last examination. At maximum follow-up, 4 patients underwent conversion to a total knee replacement (20%); their survival rate was 100% at 10 years and 66.7% at 15 years, as estimated using the Kaplan–Meier curve. The subjective Knee Society Score improved on average from 37.7 ± 10 to 63.9 ± 15.4. The objective Knee Society Score improved on average from 42.2 ± 11.7 to 75 ± 22.5. The pain detected through the VAS and NRS-11 scales improved from 56.7 ± 12.9 to 42 ± 17.1 and from 5.8 ± 1.1 to 4.4 ± 1.7, respectively. Thirteen patients (70%) required hardware removal at an average time of 19 ± 4 months due to a local nuisance. Conclusions MCW-DFO can improve symptoms in patients with osteoarthritis in a valgus knee at medium- to long-term follow-up, reducing the progression of osteoarthritis in properly selected patients.
- Published
- 2021
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295. Evidence of a recent decline in UK emissions of hydrofluorocarbons determined by the InTEM inverse model and atmospheric measurements
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A. J. Manning, A. L. Redington, D. Say, S. O'Doherty, D. Young, P. G. Simmonds, M. K. Vollmer, J. Mühle, J. Arduini, G. Spain, A. Wisher, M. Maione, T. J. Schuck, K. Stanley, S. Reimann, A. Engel, P. B. Krummel, P. J. Fraser, C. M. Harth, P. K. Salameh, R. F. Weiss, R. Gluckman, P. N. Brown, J. D. Watterson, and T. Arnold
- Subjects
Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
National greenhouse gas inventories (GHGIs) are submitted annually to the United Nations Framework Convention on Climate Change (UNFCCC). They are estimated in compliance with Intergovernmental Panel on Climate Change (IPCC) methodological guidance using activity data, emission factors and facility-level measurements. For some sources, the outputs from these calculations are very uncertain. Inverse modelling techniques that use high-quality, long-term measurements of atmospheric gases have been developed to provide independent verification of national GHGIs. This is considered good practice by the IPCC as it helps national inventory compilers to verify reported emissions and to reduce emission uncertainty. Emission estimates from the InTEM (Inversion Technique for Emission Modelling) model are presented for the UK for the hydrofluorocarbons (HFCs) reported to the UNFCCC (HFC-125, HFC-134a, HFC-143a, HFC-152a, HFC-23, HFC-32, HFC-227ea, HFC-245fa, HFC-43-10mee and HFC-365mfc). These HFCs have high global warming potentials (GWPs), and the global background mole fractions of all but two are increasing, thus highlighting their relevance to the climate and a need for increasing the accuracy of emission estimation for regulatory purposes. This study presents evidence that the long-term annual increase in growth of HFC-134a has stopped and is now decreasing. For HFC-32 there is an early indication, its rapid global growth period has ended, and there is evidence that the annual increase in global growth for HFC-125 has slowed from 2018. The inverse modelling results indicate that the UK implementation of European Union regulation of HFC emissions has been successful in initiating a decline in UK emissions from 2018. Comparison of the total InTEM UK HFC emissions in 2020 with the average from 2009–2012 shows a drop of 35 %, indicating progress toward the target of a 79 % decrease in sales by 2030. The total InTEM HFC emission estimates (2008–2018) are on average 73 (62–83) % of, or 4.3 (2.7–5.9) Tg CO2-eq yr−1 lower than, the total HFC emission estimates from the UK GHGI. There are also significant discrepancies between the two estimates for the individual HFCs.
- Published
- 2021
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296. Upgraded formulations for the onset of local mechanisms in multi-storey masonry buildings using limit analysis
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Casapulla, Claudia, Argiento, Luca U., Maione, Alessandra, and Speranza, Elena
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- 2021
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297. Structural assessment of the EU-DEMO WCLL Central Outboard Blanket segment under normal and off-normal operating conditions
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Catanzaro, Ilenia, Arena, Pietro, Basile, Salvatore, Bongiovì, Gaetano, Chiovaro, Pierluigi, Del Nevo, Alessandro, Di Maio, Pietro Alessandro, Forte, Ruggero, Maione, Ivan Alessio, and Vallone, Eugenio
- Published
- 2021
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298. Cardiovascular complications of acromegaly
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Kamenický, Peter, Maione, Luigi, and Chanson, Philippe
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- 2021
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299. Electromagnetic analysis activities in support of the Breeding Blanket during the DEMO Pre-Conceptual Design Phase: Methodology and main results
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Maione, Ivan Alessio, Roccella, Massimo, Lucca, Flavio, Villone, Fabio, Hernandez, Francisco, Del Nevo, Alessandro, and Bachmann, Christian
- Published
- 2021
- Full Text
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300. Impact of obesity on influenza compared to pneumonia hospitalization outcomes
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Wei, Chen, Qian, Frank, Liu, Ye, Maione, Luigi, Hsu, Huei-Ching, Hsu, Wan-Ting, and Lee, Chien-Chang
- Published
- 2021
- Full Text
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