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We investigated the prevalence of the JAK2 V617F gain-of-function mutation in patients with Philadelphia chromosome-negative chronic myeloproliferative disorders (Ph- MPD) and explored the links between JAK2 mutational status and the clinicopathologic picture of essential thrombocythemia (ET), chronic idiopathic myelofibrosis (CIMF), and polycythemia vera (PV). Allele-specific polymerase chain reaction results for 59 ET, 18 CIMF, and 9 PV cases were compared with values for clinical variables at presentation and last follow-up and with the diagnostic trephine bone marrow biopsy pictures. JAK2 V617F was found in 38 (64%) of ET cases, 7 (39%) of CIMF cases, and 9 (100%) of PV cases. The ET patients with the mutant JAK2 showed significantly higher (although not overtly polycythemic) red blood cell parameter values, lower platelet counts, and higher white blood cell counts. Similar trends were found in CIMF. Megakaryocyte clustering was much less pronounced in the CIMF cases with mutant JAK2, with an analogous trend occurring in the ET cases. Bone marrow cellularity values and the numbers of CD34+ and CD117+ blasts in the ET and CIMF groups did not differ. Fibrosis was slightly less marked in the ET cases with mutant JAK2. The mutation did not significantly influence the clinical course during the follow-up in either disease in the short term (median follow-up, 22 months). The JAK2 V617F mutation is prevalent in all Ph- MPD and may skew their presenting phenotype, including bone marrow histology, toward a more “erythremic” and less “thrombocythemic” phenotype.

The article makes an attempt to characterize a Polish language teacher who works in a secondary school. The author uses Polish les­sons reports which teachers fill out and tries to make generalizations concerning methodological solutions intro­duced by the teachers. Opinions of Polish language teachers who implement objectives developed as a part of ‘Tools in Action’ programme were used to analyse such elements of a lesson as: motivation situation, the topic of a lesson or innovations introduced by the teachers to already prepared lesson plans. The teachers’ comments and suggestions which were included in the reports allowed to characterize the image of a Polish language teacher and to describe selected areas of lessons. Due to their realization the perception of an educational thought inscribed within the idea of teaching as extensive humane project is possible during the Polish lessons in second­ary schools.

Insufficiency of the pituitary gland and hematological abnormalities may coexist in the context of two syndromes. In the course of some hematopoietic neoplasms, particularly acute leukemias, the pituitary insufficiency may be caused by destruction of the gland either by direct neoplastic infiltration or occlusion of vessels. Alternatively, thy pituitary dysfunction may be associated with but not caused by hematological abnormalities, usually mild peripheral cytopenias. We present four cases of the latter type (1. M/33, pituitary tumor, hypogonadism, hyperprolactinemia, anemia, mild leukopenia with leukocytosis, 2. F/54, pituitary tumor, hyperprolactinemia, thyreotropic and corticotropic insufficiency, anemia, thrombocytopenia, mild neutropenia, 3. F/27, pituitary tumor, diabetes insipidus, hypogonadism, sideropenic anemia, leukopenia, thrombocytopenia, 4. M/24, primary multihormonal insufficiency of the anterior portion of the pituitary gland, neutropenia, microcytosis). Trephine and aspiration bone marrow biopsies revealed topographic and cytological abnormalities partially resembling these found in myelodysplastic syndromes (MDS). Bone marrow cellularity varied markedly between and within the cases, and in three patients abnormal aplastic areas were found. The percentage of hematopoietic stem cells (CD34+) was low in three cases and normal in one case. Pituitary dysfunction may be associated with hematological abnormalities simulating MDS, but showing different, less aggressive clinical course. The proliferative potential of hematopoietic cells is low, the peripheral blood abnormalities are stable, and no patient developed acute leukemia. Detailed bone marrow examination, including the trephine bone marrow biopsy, is useful in differentiation with true MDS, which was also reported in the literature in the patients with pituitary insufficiency.

This study investigates the response of metallicolous (M) and nonmetallicolous (NM) ecotypes of Dianthus carthusianorum L. to chronic multi-metal and acute Zn stress. Plants were cultivated on the Zn-Pb waste heap substrate and under Zn excess in hydroponics. Growth parameters as well as accumulation of organic acids and thiol peptides were determined as a function of metal accumulation. When grown on the metalliferous substrate, the M plants showed less phytotoxicity symptoms, lower foliar metal (Zn, Pb, Cd) accumulation, higher malate and citrate but lower glutathione content than the NM plants. When exposed to Zn excess in hydroponics, the M ecotype was also more tolerant but accumulated more Zn in comparison with the NM ecotype, accompanied by greater malate and citrate concentrations in the shoots, which were however not affected by increasing Zn doses. No phytochelatins were detected under any experimental conditions. Both constitutive and adaptive tolerance was found in D. carthusianorum. Under chronic metal stress, enhanced tolerance results from restricted metal uptake to the shoots and probably from detoxification by organic acids; however, under acute Zn stress it is not related to diminished metal uptake or organic acids. Glutathione and phytochelatins are not implicated in adaptive metal tolerance.

"Problematyka dotycząca rozwoju powieści dla dziewcząt doczekała się wszechstronnego opracowania naukowego, uwzględniającego m.in. periodyzację jej ewolucji, genologię, przemiany głównej bohaterki, powielanie i interpretację znanych motywów oraz powinowactwo z baśnią. Niemałą rolę w zgłębianiu tych kwestii odegrały badania nad powieścią dla dziewcząt po 1945 roku2." [fragment tekstu]

The article is an attempt to critically read Lucyna Sadzikowska’s book Listy z lagrów i więzień 1939−1945. Wybrane zagadnienia (Letters from the labor camps and prisons 1939-1945. Selected issues) published in 2019. The publication presents the methodological contexts of the camp correspondence study. Małgorzata Wójcik-Dudek critically analyzes the theory of letter used by the author as a message and comments on the results of research by a Silesian literary researcher.

W a rtykule opisane zostały przestrzenie i nspirowane refleksją pedagogiczną Janusza Korczaka, znajdujące się w Muzeum Historii Żydów Polskich POLIN: miejsce edukacji rodzinnej „U króla Maciusia” oraz wystawa „W Polsce króla Maciusia. 100-lecie odzyskania niepodległości”. Autorka ukazała, w jaki sposób zwrot edukacyjny we współczesnym muzealnictwie przełożył się na rozwój koncepcji przestrzeni muzealnej przeznaczonej dla dzieci. Koncepcja ta w dużym stopniu wyrasta ze współczesnych teorii wychowania, począwszy od konstruktywizmu Johna Deweya, przez pedagogikę Janusza Korczaka, aż po popularne dziś skandynawskie modele wychowania.

The article is an attempt to show the ritual of dining as a tool of oppression applied to children. Literature aimed at children tries to help them overcome the trauma of eating process by showing culinary experience as a social event, which is the beginning of reflection on freedom, possibilities of making choices or building one’s own identity. According to the author the collection of poems by Natalia Usenko serves that purpose.

In the article, the Kabbalistic interpretation by Władysław Panas (contained in his treatise Księga blasku ‘The Book of Radiance’) of the titular short story from Bruno Schulz’s Sklepy cynamonowe (“The Cinnamon Shops”) was adapted by the author with a view to utilizing it during a Polish lesson. As the author of the article puts forward, the pivotal notion for the short story under analysis is the mysticism of light, the presence of which guarantees the world order. Interpreting “The Cinnamon Shops” in the context of Judaist topics, while leaving aside the contexts suggested by the literary history and biography, allows to indicate other, quite inspiring, interpretive possibilities. The latter convincingly reinforce Schulz’s exceptional place in the canon of Polish literature and, most of all, prove that his oeuvre still requires from the contemporary readers not only the skill of close reading, but also highly developed aesthetic sensitivity.

Tak brzmi jedno z pierwszych zdań Stereotypu czarownicy i jego modyfikowania…, ważnej książki dostojnej Jubilatki. Książki na tyle inspirującej, że pozwalam sobie na krótki komentarz, który choć nie ma językowego charakteru, to wynika z ustaleń poczynionych przez Badaczkę. We wspomnianej publikacji jak w soczewce skupiają się przecież obszary zainteresowań naukowych jej Autorki: językowy obraz świata, dydaktyka oraz literatura dla dzieci i młodzieży. Tym samym wydaje się, że w miarę udaną próbą wejścia w dialog z dyskursem naukowym reprezentowanym przez Bernadetę Niesporek‑Szamburską byłby literacki ogląd tekstu należącego do współczesnej literatury czwartej, który przedstawiałby problem inicjacji czytelniczej jako moment magiczny (Fragment tekstu).