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814 results on '"Ma, Lie"'

261. Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer

Author

Zhu, Cai-xia, Xiong, Wei, Wang, Ma-lie, Yang, Juan, Shi, Hui-juan, Chen, Han-qing, and Niu, Gang

Abstract

Objective To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer.Methods Nuclear and cytoplasmic GPR30 expressions were determined using immunohistochemistry to identify the intracellular location in tissues from patients with ovarian cancer. Data were correlated with clinicopathological characteristics and outcomes.Results Tissue samples were obtained from 110 patients with epithelial ovarian cancer between 2005 and 2010. Nuclear GPR30 was significantly more frequent in the group of patients with recurrence. The presence of nuclear GPR30 predicted lower overall survival) and 5-year progression-free survival in all patients with ovarian cancer and overall survival in patients with high grade ovarian cancer. Cytoplasmic GPR30 was observed significantly more often in advanced ovarian cancer and did not predict survival.Conclusion This study showed that nuclear GPR30 is an independent negative prognostic indicator in patients with ovarian cancer, especially in those with a high grade malignancy.

Published
2018
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262. In situassembly of fibrinogen/hyaluronic acid hydrogel via knob-hole interaction for 3D cellular engineering

Author

Huang, Shengjie, Wang, Chunfen, Xu, Jingwei, Ma, Lie, and Gao, Changyou

Abstract

Hyaluronic acid (HA)-based hydrogels have applied widely for biomedical applications due to its biocompatibility and biodegradability. However, the use of initiators or crosslinkers during the hydrogel formation may cause cytotoxicity and thereby impair the biocompatibility. Inspired by the crosslinking mechanism of fibrin gel, a novel HA-based hydrogel was developed via the in situsupramolecular assembly based on knob-hole interactions between fibrinogen and knob-grafted HA (knob-g-HA) in this study. The knob-grafted HA was synthesized by coupling knob peptides (GPRPAAC, a mimic peptide of fibrin knob A) to HA via Michael addition. Then the translucent fibrinogen/knob-g-HA hydrogels were prepared by simply mixing the solutions of knob-g-HA and fibrinogen at the knob/hole ratio of 1.2. The rheological behaviors of the fibrinogen/knob-g-HA hydrogels with the fibrinogen concentrations of 50, 100 and 200 mg/mL were evaluated, and it was found that the dynamic storage moduli (G′) were higher than the loss moduli (G″) over the whole frequency range for all the groups. The SEM results showed that fibrinogen/knob-g-HA hydrogels presented the heterogeneous mesh-like structures which were different from the honeycomb-like structures of fibrinogen/MA-HA hydrogels. Correspondingly, a higher swelling ratio was obtained in the groups of fibrinogen/knob-g-HA hydrogel. Finally, the cytocompatibility of fibrinogen/knob-g-HA hydrogels was proved by live/dead stainings and MTT assays in the 293T cells encapsulation test. All these results highlight the biological potential of the fibrinogen/knob-g-HA hydrogels for 3D cellular engineering.

Published
2017
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265. A study of turning gait control for quadruped walking vehicle

Author

Ma Lie and Ma Peisun

Subjects
Gait (human), Computer science, Gait control, Robot, Mobile robot, Gait, Simulation
Abstract

This paper studies the realization of turning gait control, taking a quadruped walking vehicle as the subject of the research. Based on the analyses of previous works, a kind of turning gait with the center of gravity of the vehicle walking along multiple broken lines has been planned, which is more suitable for practical control than previous methods. The process of the turning gait and its feasibility are discussed in detail. The turning gait presented is being implemented in the omnidirectional quadruped walking robot JTUWM-II. >

Published
2002

266. Knowledge based error recovery in robotized assembly

Author

Ma Lie and Qian Wenhan

Subjects
Structure (mathematical logic), Knowledge-based systems, Engineering, business.industry, Failure diagnosis, Embedded system, Functional module, Testbed, Modular design, business
Abstract

Presents a framework of an online knowledge based error recovery system for robotized assembly, which deals with problems of execution monitoring, sensor processing, failure diagnosis and recovery. The system is of modular and hierarchical structure. Techniques have been integrated into each functional module. Based on the presented framework, the authors have also investigated the way to implement the proposed system in their testbed. The prototype has been realized at the first stage using V+ as the main tool. >

Published
2002

267. Validation of the vault prediction model based on the sulcus-to-sulcus diameter and lens thickness: a 925-eye prospective study.

Author

Zhu, Qiu-Jian, Xing, Xiao-Ying, Zhu, Man-Hui, Ma, Lie, Yuan, You, and Song, E

Subjects
UVEA, SEASONS, LONGITUDINAL method
Abstract

Background: To verify the accuracy and stability of the prediction formula based on the ciliary sulcus diameter and lens thickness and to analyse factors influencing the prediction results.Methods: In total, 925 eyes from 506 subjects were enrolled in this prospective study between July 1, 2020, and June 30, 2021. Subjects were divided into four seasons, each spanning three months. The target vault was set to be between 300 μm and 700 μm according the prediction formula. The actual vault was measured one month postoperatively. The Bland-Altman test, 95% confidence intervals (95% CI) and 95% limits of agreement (95% LoA) were used to evaluate the agreement between the predicted vault and the actual vault. Eyes with absolute prediction errors greater than 300 μm were further analysed.Results: The mean predicted vaults for the four seasons were 503 ± 99, 494 ± 96, 481 ± 92 and 502 ± 93 μm, while the mean actual vaults were 531 ± 189, 491 ± 179, 464 ± 179 and 529 ± 162 μm, respectively. The predicted and actual vaults of the overall subjects were 493 ± 95 and 500 ± 180 μm, respectively. Of the 925 eyes, 861 eyes (93.08%), 42 eyes (4.54%), and 22 eyes (2.38%) showed a normal vault, high vault, and low vault, respectively. Bland-Altman plots showed that the mean difference between the actual vault and predicted vault overall (± 95% LoA) was 6.43 ± 176.2 μm (-339 to 352 μm). Three UBM features may lead to large prediction errors (more than 300 μm): wide iris-ciliary angle (ICA), iris concavity and anteriorly positioned ciliary body.Conclusions: This study demonstrated the accuracy and stability of the prediction formula through the validation of a large sample size and a long time span. Wide ICA, iris concavity and anteriorly positioned ciliary body may have an effect on vault. [ABSTRACT FROM AUTHOR]

Published
2022
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269. Liver transplantation in acute-on-chronic liver failure patients with high model for end-stage liver disease (MELD) scores: a single center experience of 100 consecutive cases

Author

Duan, Bin-Wei, primary, Lu, Shi-Chun, additional, Wang, Meng-Long, additional, Liu, Jin-Ning, additional, Chi, Ping, additional, Lai, Wei, additional, Wu, Ju-Shan, additional, Guo, Qing-Liang, additional, Lin, Dong-Dong, additional, Liu, Yuan, additional, Zeng, Dao-Bing, additional, Li, Chuan-Yun, additional, Meng, Qing-Hua, additional, Ding, Hui-Guo, additional, Chen, Xin-Yue, additional, Liao, Hui-Yu, additional, Ma, Lie-Qing, additional, Chen, Yu, additional, Zhang, Jing, additional, Xiang, Hai-Ping, additional, Duan, Zhong-Ping, additional, and Li, Ning, additional

Published
2013
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277. Aurovertin-Type Polyketides from Calcarisporium arbuscula with Potent Cytotoxic Activities against Triple-Negative Breast Cancer.

Author

Zhao, Hong, Wu, Rui, Ma, Lie‐Feng, Wo, Li‐Ke, Hu, Yuan‐Yuan, Chen, Chao, and Zhan, Zha‐Jun

Abstract

Two new polyene polyketides, namely aurovertins T and U ( 1 and 2), were isolated from Calcarisporium arbuscula, together with aurovertins B ( 3), D and E ( 4 and 5), and M ( 6). The structures were elucidated by extensive spectroscopic methods (especially 2D- NMR techniques). The cytotoxic activities of all isolates against human triple-negative breast cancer cell line ( MDA- MB-231) were evaluated. As a result, compounds 3, 4, and 6 exhibited more potent cytotoxic activities against MDA- MB-231 cell line than the positive control taxol. Also, discussion about the relationships between structure and activity of these aurovertins was presented. [ABSTRACT FROM AUTHOR]

Published
2016
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278. CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse.

Author

Guan, Yuting, Ma, Yanlin, Li, Qi, Sun, Zhenliang, Ma, Lie, Wu, Lijuan, Wang, Liren, Zeng, Li, Shao, Yanjiao, Chen, Yuting, Ma, Ning, Lu, Wenqing, Hu, Kewen, Han, Honghui, Yu, Yanhong, Huang, Yuanhua, Liu, Mingyao, and Li, Dali

Abstract

The X-linked genetic bleeding disorder caused by deficiency of coagulator factor IX, hemophilia B, is a disease ideally suited for gene therapy with genome editing technology. Here, we identify a family with hemophilia B carrying a novel mutation, Y371D, in the human F9 gene. The CRISPR/Cas9 system was used to generate distinct genetically modified mouse models and confirmed that the novel Y371D mutation resulted in a more severe hemophilia B phenotype than the previously identified Y371S mutation. To develop therapeutic strategies targeting this mutation, we subsequently compared naked DNA constructs versus adenoviral vectors to deliver Cas9 components targeting the F9 Y371D mutation in adult mice. After treatment, hemophilia B mice receiving naked DNA constructs exhibited correction of over 0.56% of F9 alleles in hepatocytes, which was sufficient to restore hemostasis. In contrast, the adenoviral delivery system resulted in a higher corrective efficiency but no therapeutic effects due to severe hepatic toxicity. Our studies suggest that CRISPR/Cas-mediated in situ genome editing could be a feasible therapeutic strategy for human hereditary diseases, although an efficient and clinically relevant delivery system is required for further clinical studies. [ABSTRACT FROM AUTHOR]

Published
2016
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284. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

Author

Wang, Di, primary, Zheng, Mingzhu, additional, Lei, Lei, additional, Ji, Jian, additional, Yao, Yunliang, additional, Qiu, Yuanjun, additional, Ma, Lie, additional, Lou, Jun, additional, Ouyang, Chuan, additional, Zhang, Xue, additional, He, Yuewei, additional, Chi, Jun, additional, Wang, Lie, additional, Kuang, Ying, additional, Wang, Jianli, additional, Cao, Xuetao, additional, and Lu, Linrong, additional

Published
2012
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287. A construct of adipose-derived mesenchymal stem cells—laden collagen scaffold for fertility restoration by inhibiting fibrosis in a rat model of endometrial injury

Author

Dai, Yangyang, Xin, Liaobing, Hu, Sentao, Xu, Shiqian, Huang, Dong, Jin, Xiaoying, Chen, Jianmin, Chan, Rachel Wah Shan, Ng, Ernest Hung Yu, Yeung, William Shu Biu, Ma, Lie, and Zhang, Songying

Abstract

Severe endometrium damage causes pathological conditions such as thin endometrium and intrauterine adhesion, resulting in uterine factor infertility. Mesenchymal stem cell (MSC) therapy is a promising strategy in endometrial repair; yet, exogenous MSCs still raise concerns for safety and ethical issues. Human adipose-derived mesenchymal stem cells (ADMSCs) residing in adipose tissue have high translational potentials due to their autologous origin. To harness the high translation potentials of ADMSC in clinical endometrium regeneration, here we constructed an ADMSCs composited porous scaffold (CS/ADMSC) and evaluated its effectiveness on endometrial regeneration in a rat endometrium-injury model. We found that CS/ADMSC intrauterine implantation (i) promoted endometrial thickness and gland number, (ii) enhanced tissue angiogenesis, (iii) reduced fibrosis and (iv) restored fertility. We ascertained the pro-proliferation, pro-angiogenesis, immunomodulating and anti-fibrotic effects of CS/ADMSC in vitroand revealed that the CS/ADMSC influenced extracellular matrix composition and organization by a transcriptomic analysis. Our results demonstrated the effectiveness of CS/ADMSC for endometrial regeneration and provided solid proof for our future clinical study.

Published
2023
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289. Design and preliminary test results of Daya Bay RPC modules

Author

Xu, Ji-Lei, primary, Guan, Meng-Yun, additional, Yang, Chang-Gen, additional, Wang, Yi-Fang, additional, Zhang, Jia-Wen, additional, Lu, Chang-Guo, additional, McDonald, Kirk, additional, Hackenburg, Robert, additional, Lau, Kwong, additional, Lebanowski, Logan, additional, Newsom, Cullen, additional, Shih-Kai, Lin, additional, Link, Jonathan, additional, Ma, Lie-Hua, additional, Pěč, Viktor, additional, Vorobel, Vit, additional, Chen, Jin, additional, Liu, Jin-Chang, additional, Zhou, Yong-Zhao, additional, and Liang, Hao, additional

Published
2011
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299. Macromol. Chem. Phys. 4/2010

Author

Zhou, Jie, primary, Romero, Gabriela, additional, Rojas, Elena, additional, Moya, Sergio, additional, Ma, Lie, additional, and Gao, Changyou, additional

Published
2010
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