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256. PROMOTING HEALTHY EMPLOYEE LIFESTYLES

Author

Dolores M Alford

Subjects
Gerontology, Health promotion, Geriatric Nursing, Life style, MEDLINE, Humans, Gerontological nursing, Health Promotion, Models, Psychological, Psychology, Life Style, General Nursing
Published
1985
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262. The use of the international classification of functioning, disability and health (ICF) in indigenous healthcare: a systematic literature review

Author

Gillian Webb, Shaun Ewen, Louisa Remedios, and Vanessa M Alford

Subjects
030506 rehabilitation, medicine.medical_specialty, Population, Person centered, Review, Indigenous, WHO, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, International Classification of Functioning, Disability and Health, International Classification of Diseases, Bio-psychosocial, Activities of Daily Living, Health care, medicine, Health Services, Indigenous, Humans, Functioning, 030212 general & internal medicine, 10. No inequality, Socioeconomics, education, Health policy, Medical education, education.field_of_study, business.industry, Research, Public health, Health Policy, Healthcare, ICF, Australia, Health services research, Public Health, Environmental and Occupational Health, Health equity, 3. Good health, Health, 0305 other medical science, business
Abstract

Introduction: The International Classification of Functioning, Disability and Health (ICF) was endorsed by the World Health Organisation (WHO) in 2001 to obtain a comprehensive perspective of health and functioning of individuals and groups. Health disparities exist between Indigenous and non-Indigenous Australians and there is a need to understand the health experiences of Indigenous communities from Indigenous Australian’s perspectives in order to develop and implement culturally appropriate and effective intervention strategies to improve Indigenous health. This systematic review examines the literature to identify the extent and context of use of the ICF in Indigenous healthcare, to provide the foundation on which to consider its potential use for understanding the health experiences of Indigenous communities from their perspective. Methods: The search was conducted between May and June 2012 of five scientific and medical electronic databases: MEDLINE, Web of Science, CINAHL, Academic Search Complete and PsychInfo and six Indigenousspecific databases: AIATSIS, APAIS-health, ATSI-health, health and society, MAIS-ATSIS and RURAL. Reference lists of included papers were also searched. Articles which applied the ICF within an Indigenous context were selected. Quantitative and qualitative data were extracted and analysed by two independent reviewers. Agreement was reached by consensus. Results: Five articles met the inclusion criteria however two of the articles were not exclusively in an Indigenous context. One article applied the ICF in the context of understanding the health experience and priorities of Indigenous people and a second study had a similar focus but used the revised version of the International Classification of Impairments, Disability and Handicap (ICIDH-2), the predecessor to the ICF. Four of the five papers involved Indigenous Australians, and one of the paper’s participants were Indigenous (First Nation) Canadians. Conclusion: Literature referring to the use of the ICF with Indigenous populations is limited. The ICF has the potential to help understand the health and functioning experience of Indigenous persons from their perspective. Further research is required to determine if the ICF is a culturally appropriate tool and whether it is able to capture the Indigenous health experience or whether modification of the framework is necessary for use with this population.

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263. The LOFT mission concept: a status update

Author

Feroci, M, Bozzo, E, Brandt, S, Hernanz, M, Van Der Klis, M, Liu, L, Orleanski, P, Pohl, M, Santangelo, A, Schanne, S, Stella, L, Takahashi, T, Tamura, H, Watts, A, Wilms, J, Zane, S, Zhang, S, Bhattacharyya, S, Agudo, I, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J, Azzarello, P, Bakala, P, Ballantyne, Dr, Baldazzi, G, Baldo, M, Balman, S, Barbera, M, Van Baren, C, Barret, D, Baykal, A, Begelman, M, Behar, E, Behar, O, Belloni, T, Bellutti, P, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bode, M, Bodin, P, Bombaci, I, Bonnet Bidaud, J, Borghi, G, Boutloukos, S, Bouyjou, F, Bradley, L, Braga, J, Briggs, Ms, Brown, E, Buballa, M, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jorgensen, C, Cackett, E, Cadoux, Fr, Cais, P, Caliandro, Ga, Campana, R, Campana, S, Cao, X, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, Aj, Cavazzuti, E, Cavechi, Y, Celestin, S, Cerda-Duran, P, Chakrabarty, D, Chamel, N, Chateau, F, Chen, C, Chen, Y, Chenevez, J, Chernyakova, M, Coker, J, Cole, R, Collura, A, Coriat, M, Cornelisse, R, Costamante, L, Cros, A, Cui, W, Cumming, A, Cusumano, G, Czerny, B, D'Ai, A, D'Ammando, F, D'Elia, V, Dai, Z, Del Monte, E, De Luca, A, De Martino, D, Dercksen, Jpc, De Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Degenaar, N, Den Herder, Jw, Diebold, S, Di Salvo, T, Dong, Y, Donnarumma, I, Doroshenko, V, Doyle, G, Drake, Sa, Durant, M, Emmanoulopoulos, D, Enoto, T, Erkut, Mh, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Fender, R, Feng, H, Ferrari, V, Ferrigno, C, Ficorella, F, Finger, M, Finger, Mh, Fraser, Gw, Frericks, M, Fullekrug, M, Fuschino, F, Gabler, M, Galloway, Dk, Galvez Sanchez, Jl, Gandhi, P, Gao, Z, Garcia-Berro, E, Gendre, B, Gevin, O, Gezari, S, Giles, Ab, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Gogus, E, Goldwurm, A, Goluchova, K, Gotz, D, Gou, L, Gouiffes, C, Grandi, P, Grassi, M, Greiner, J, Grinberg, V, Groot, P, Gschwender, M, Gualtieri, L, Guedel, M, Guidorzi, C, Guy, L, Haas, D, Haensel, P, Hailey, M, Hamuguchi, K, Hansen, F, Hartmann, Dh, Haswell, Ca, Hebeler, K, Heger, A, Hempel, M, Hermsen, W, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Huppenkothen, D, Inam, Sc, Ingram, A, In'Tzand, Jjm, Israel, G, Iwasawa, K, Izzo, L, Jacobs, Hm, Jetter, F, Johannsen, T, Jenke, Pa, Jonker, P, Jose, J, Kaaret, P, Kalamkar, M, Kalemci, E, Kanbach, G, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Koerding, E, Kokkotas, K, Komossa, S, Korpela, S, Kouveliotou, C, Kowalski, Af, Kreykenbohm, I, Kuiper, Lm, Kunneriath, D, Kurkela, A, Kuvvetli, I, La Franca, F, Labanti, C, Lai, D, Lamb, Fk, Lachaud, C, Laubert, Pp, Lebrun, F, Li, X, Liang, E, Limousin, O, Lin, D, Linares, M, Linder, D, Lodato, G, Longo, F, Lu, F, Lund, N, Maccarone, Tj, Macera, D, Maestre, S, Mahmoodifar, S, Maier, D, Malcovati, P, Malzac, J, Malone, C, Mandel, I, Mangano, V, Manousakis, A, Marelli, M, Margueron, J, Marisaldi, M, Markoff, Sb, Markowitz, A, Marinucci, A, Martindale, A, Martinez, G, Mchardy, Im, Medina-Tanco, G, Mehdipour, M, Melatos, A, Mendez, M, Mereghetti, S, Migliari, S, Mignani, R, Michalska, M, Mihara, T, Miller, Mc, Miller, Jm, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Mouret, G, Mulacova, J, Muleri, F, Munoz-Darias, T, Negueruela, I, Neilsen, J, Neubert, T, Norton, Aj, Nowak, M, Nucita, A, O'Brien, P, Oertel, M, Olsen, Peh, Orienti, M, Orio, M, Orlandini, M, Osborne, Jp, Osten, R, Ozel, F, Pacciani, L, Paerels, F, Paltani, S, Paolillo, M, Papadakis, I, Papitto, A, Paragi, Z, Paredes, Jm, Patruno, A, Paul, B, Pederiva, F, Perinati, E, Pellizzoni, A, Penacchioni, Av, Peretz, U, Perez, Ma, Perez-Torres, M, Peterson, Bm, Petracek, V, Picciotto, A, Piemonte, C, Pittori, C, Pons, J, Portell, J, Possenti, A, Postnov, K, Poutanen, J, Prakash, M, Prandoni, I, Le Provost, H, Psaltis, D, Pye, J, Qu, J, Rambaud, D, Ramon, P, Ramsay, G, Rapisarda, M, Rachevski, A, Rashevskaya, I, Ray, Ps, Rea, N, Reddy, S, Reig, P, Reina Aranda, M, Remillard, R, Reynolds, C, Rezzolla, L, Ribo, M, De La Rie, R, Riggio, A, Rios, A, Rischke, Dh, Rodriguez-Gil, P, Rodriguez, J, Rohlfs, R, Romano, P, Rossi, Emr, Rozanska, A, Rousseau, A, Rudak, B, Russell, Dm, Ryde, F, Sabau-Graziati, L, Sakamoto, T, Sala, G, Salvaterra, R, Salvetti, D, Sanna, A, Sandberg, J, Savolainen, T, Scaringi, S, Schaffner-Bielich, J, Schatz, H, Schee, J, Schmid, C, Serino, M, Shakura, N, Shore, S, Schnittman, Jd, Schneider, R, Schwenk, A, Schwope, Ad, Sedrakian, A, Seyler, J, Shearer, A, Slowikowska, A, Sims, M, Smith, A, Smith, Dm, Smith, Pj, Sobolewska, M, Sochora, V, Soffitta, P, Soleri, P, Song, L, Spencer, A, Stamerra, A, Stappers, B, Staubert, R, Steiner, Aw, Stergioulas, N, Stevens, Al, Stratta, G, Strohmayer, Te, Stuchlik, Z, Suchy, S, Suleimanov, V, Tamburini, F, Tauris, T, Tavecchio, F, Tenzer, C, Thielemann, Fk, Tiengo, A, Tolos, L, Tombesi, F, Tomsick, J, Torok, G, Torrejon, Jm, Torres, Df, Torresi, E, Tramacere, A, Traulsen, I, Trois, A, Turolla, R, Turriziani, S, Typel, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vietri, M, Vincent, Fh, Vrba, V, Walton, D, Wang, J, Wang, Z, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wille, M, Wilson-Hodge, Ca, Winter, B, Walk, Sj, Wood, K, Woosley, Se, Wu, X, Xiao, L, Xu, R, Yu, W, Yuan, F, Yuan, W, Yuan, Y, Zampa, G, Zampa, N, Zampieri, L, Zdunik, L, Zdziarski, A, Zech, A, Zhang, B, Zhang, C, Zingale, M, Zorzi, N, Zwart, F, High Energy Astrophys. & Astropart. Phys (API, FNWI), ISDC Data Centre for Astrophysics, Université de Genève = University of Geneva (UNIGE), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers), Institut für Astronomie und Astrophysik [Tübingen] (IAAT), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze e Tecnologie Chimiche, Università degli Studi di Roma Tor Vergata [Roma], Graduate School of the Natural Science and Technology [Kanazawa], Kanazawa University (KU), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Tampere University of Technology [Tampere] (TUT), University of Maryland [College Park], University of Maryland System, Department of Biological Sciences [Mississippi], University of Southern Mississippi (USM), School of Physics and Astronomy [Southampton], University of Southampton, Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), Istituto Nazionale di Astrofisica (INAF), Università di Roma La Sapienza, Università di Roma Tor Vergata, Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées (LATT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Swedish Institute of Space Physics [Uppsala] (IRF), INAF - Osservatorio Astronomico di Brera (OAB), Department of Computer Sciences [Scheffield], University of Sheffield [Sheffield], Colgate University, Bibliothèque nationale de France (BnF), Istituto di Astrofisica Spaziale e Fisica cosmica - Palermo (IASF-Pa), ARC Centre of Excellence for Environmental Decisions (ARC CEED), The University of Western Australia (UWA)-Australian National University (ANU)-University of Queensland [Brisbane]-Royal Melbourne Institute of Technology University (RMIT University)-School of BioSciences [Melbourne], Faculty of Science [Melbourne], University of Melbourne-University of Melbourne-Faculty of Science [Melbourne], University of Melbourne-University of Melbourne, ARC Centre of Excellence for Coral Reef Studies (CoralCoE), James Cook University (JCU), Lund University [Lund], Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de synthèse organique (DCSO), École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Alabama at Birmingham [ Birmingham] (UAB), INAF - Osservatorio Astronomico di Cagliari (OAC), ELECTRONIQUE 2016, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), School of Geosciences, Monash University [Clayton], Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université libre de Bruxelles (ULB), National Oceanography Centre [Southampton] (NOC), Dublin Institute for Advanced Studies (DIAS), Dublin City University [Dublin] (DCU), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Sciences [Beijing] (CAS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), China Information Technology Security Evaluation Center (CNITSEC), Department of Applied Mathematics and Computer Science [Lyngby] (DTU Compute), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), PCAS, Anton Pannekoek Institute for Astronomy, Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), International Space Science Institute [Bern] (ISSI), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CALVIN research group [Edinburgh], Institute of Perception, Action and Behaviour (IPAB), University of Edinburgh-University of Edinburgh, Department of Electronics and Electrical Engineering [Bath], University of Bath [Bath], United States Geological Survey [Reston] (USGS), Sr. PLM Consultant, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Dept Ind Engn & Informat Techonolgy, Università degli studi di Trieste = University of Trieste, Max-Planck-Institut für Extraterrestrische Physik (MPE), MIT Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology (MIT), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Wisconsin Regional Primate Research Center, University of Wisconsin-Madison, SRON Netherlands Institute for Space Research (SRON), Opole University of Technology, University of Technology (Opole), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud University [Nijmegen]-Radboud University [Nijmegen], Radboud University [Nijmegen], NASA Goddard Space Flight Center (GSFC), Dept Fis Aplicada, Universidad de Granada = University of Granada (UGR), Victoria University [Melbourne], The Hong Kong Polytechnic University [Hong Kong] (POLYU), Chinese Academy of Sciences [Changchun Branch] (CAS), Department of Physics, Chemistry and Biology [Linköping] (IFM), Linköping University (LIU), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institute of Astronomy, University of Zielona Góra, Department of Electronics and Computer Systems, Takushoku University, Instituto Nacional de Pesquisas da Amazônia (INPA), Università degli studi di Catania = University of Catania (Unict), Centre d'Ecologie et des Sciences de la COnservation (CESCO), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Physico-Chimie de l'Atmosphère (LPCA), Université du Littoral Côte d'Opale (ULCO)-Centre National de la Recherche Scientifique (CNRS), HEPL, Solar Physics, Stanford University, Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Space Telescope Science Institute (STSci), Dipartimento di Scienze Fisiche [Naples], University of Naples Federico II = Università degli studi di Napoli Federico II, Columbia University [New York], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Department of Anthropology [University of Arkansas], University of Arkansas [Fayetteville], Hu county ventre for disease control and prevention of Shaanxi province, Istituto Nazionale di Fisica Nucleare, Sezione di Trieste (INFN, Sezione di Trieste), Istituto Nazionale di Fisica Nucleare (INFN), Institut Jean le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciencies de l'Espai [Barcelona] (ICE-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Reading (UOR), Departamento de Matemática Aplicada, Universidade de Santiago de Compostela [Spain] (USC ), Osservatorio Astrofisico di Catania, Équipe Robotique et InteractionS (LAAS-RIS), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centro Euro-Mediterraneo per i Cambiamenti Climatici [Bologna] (CMCC), Institut für Theoretische Physik, Universität Heidelberg [Heidelberg] = Heidelberg University, Augsburg Hospital, Leibniz-Institut für Astrophysik Potsdam (AIP), Daimler Chrysler AG (Daimler), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Montserrat Volcano Observatory (MVO), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Jodrell Bank Centre for Astrophysics, University of Manchester [Manchester], FICLIT, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Max-Planck-Institut für Radioastronomie (MPIFR), Argelander-Institut für Astronomie (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Christian-Albrechts-Universität zu Kiel (CAU), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Cahill Center for Astronomy and Astrophysics, California Institute of Technology (CALTECH), Xinjiang Astronomical Observatory, Mitsubishi Electric Research Laboratories (MERL), Mitsubishi Research Institute, Inc., School of Urban and Regional Planning, University of Southern California (USC), National University of Defense Technology [China], Princeton University, Department of Microtechnology and Nanoscience (MC2), Chalmers University of Technology [Gothenburg, Sweden], Feroci, M., Bozzo, E., Brandt, S., Hernanz, M., van der Klis, M., Liu, L., Orleanski, P., Pohl, M., Santangelo, A., Schanne, S., Stella, L., Takahashi, T., Tamura, H., Watts, A., Wilms, J., Zane, S., Zhang, S., Bhattacharyya, S., Agudo, I., Ahangarianabhari, M., Albertus, C., Alford, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Artigues, B., Atteia, J., Azzarello, P., Bakala, P., Ballantyne, D., Baldazzi, G., Baldo, M., Balman, S., Barbera, M., van Baren, C., Barret, D., Baykal, A., Begelman, M., Behar, E., Behar, O., Belloni, T., Bernardini, F., Bertuccio, G., Bianchi, S., Bianchini, A., Binko, P., Blay, P., Bocchino, F., Bode, M., Bodin, P., Bombaci, I., Bonnet Bidaud, J., Boutloukos, S., Bouyjou, F., Bradley, L., Braga, J., Briggs, M., Brown, E., Buballa, M., Bucciantini, N., Burderi, L., Burgay, M., Bursa, M., Budtz Jørgensen, C., Cackett, E., Cadoux, F., Cais, P., Caliandro, G., Campana, R., Campana, S., Cao, X., Capitanio, F., Casares, J., Casella, P., Castro Tirado, A., Cavazzuti, E., Cavechi, Y., Celestin, S., Cerda Duran, P., Chakrabarty, D., Chamel, N., Château, F., Chen, C., Chen, Y., Chenevez, J., Chernyakova, M., Coker, J., Cole, R., Collura, A., Coriat, M., Cornelisse, R., Costamante, L., Cros, A., Cui, W., Cumming, A., Cusumano, G., Czerny, B., D'Aì, A., D'Ammando, F., D'Elia, V., Dai, Z., Del Monte, E., De Luca, A., De Martino, D., Dercksen, J., De Pasquale, M., De Rosa, A., Del Santo, M., Di Cosimo, S., Degenaar, N., den Herder, J., Diebold, S., DI SALVO, T., Dong, Y., Donnarumma, I., Doroshenko, V., Doyle, G., Drake, S., Durant, M., Emmanoulopoulos, D., Enoto, T., Erkut, M., Esposito, P., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Fender, R., Feng, H., Ferrari, V., Ferrigno, C., Finger, M., Fraser, G., Frericks, M., Fullekrug, M., Fuschino, F., Gabler, M., Galloway, D., Gálvez Sanchez, J., Gandhi, P., Gao, Z., Garcia Berro, E., Gendre, B., Gevin, O., Gezari, S., Giles, A., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Gogus, E., Goldwurm, A., Goluchová, K., Götz, D., Gou, L., Gouiffes, C., Grandi, P., Grassi, M., Greiner, J., Grinberg, V., Groot, P., Gschwender, M., Gualtieri, L., Guedel, M., Guidorzi, C., Guy, L., Haas, D., Haensel, P., Hailey, M., Hamuguchi, K., Hansen, F., Hartmann, D., Haswell, C., Hebeler, K., Heger, A., Hempel, M., Hermsen, W., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Huppenkothen, D., Inam, S., Ingram, A., In't Zand, J., Israel, G., Iwasawa, K., Izzo, L., Jacobs, H., Jetter, F., Johannsen, T., Jenke, P., Jonker, P., Josè, J., Kaaret, P., Kalamkar, K., Kalemci, E., Kanbach, G., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Koerding, E., Kokkotas, K., Komossa, S., Korpela, S., Kouveliotou, C., Kowalski, A., Kreykenbohm, I., Kuiper, L., Kunneriath, D., Kurkela, A., Kuvvetli, I., La Franca, F., Labanti, C., Lai, D., Lamb, F., Lachaud, C., Laubert, P., Lebrun, F., Li, X., Liang, E., Limousin, O., Lin, D., Linares, M., Linder, D., Lodato, G., Longo, F., Lu, F., Lund, N., Maccarone, T., Macera, D., Maestre, S., Mahmoodifar, S., Maier, D., Malcovati, P., Malzac, J., Malone, C., Mandel, I., Mangano, V., Manousakis, A., Marelli, M., Margueron, J., Marisaldi, M., Markoff, S., Markowitz, A., Marinucci, A., Martindale, A., Martínez, G., Mchardy, I., Medina Tanco, G., Mehdipour, M., Melatos, A., Mendez, M., Mereghetti, S., Migliari, S., Mignani, R., Michalska, M., Mihara, T., Miller, M., Miller, J., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Mouret, G., Mulačová, J., Muleri, F., Muñoz Darias, T., Negueruela, I., Neilsen, J., Neubert, T., Norton, A., Nowak, M., Nucita, A., O'Brien, P., Oertel, M., Olsen, P., Orienti, M., Orio, M., Orlandini, M., Osborne, J., Osten, R., Ozel, F., Pacciani, L., Paerels, F., Paltani, S., Paolillo, M., Papadakis, I., Papitto, A., Paragi, Z., Paredes, J., Patruno, A., Paul, B., Pederiva, F., Perinati, E., Pellizzoni, A., Penacchioni, A., Peretz, U., Perez, M., Perez Torres, M., Peterson, B., Petracek, V., Pittori, C., Pons, J., Portell, J., Possenti, A., Postnov, K., Poutanen, J., Prakash, M., Prandoni, I., Le Provost, H., Psaltis, D., Pye, J., Qu, J., Rambaud, D., Ramon, P., Ramsay, G., Rapisarda, M., Rashevski, A., Rashevskaya, I., Ray, P., Rea, N., Reddy, S., Reig, P., Reina Aranda, M., Remillard, R., Reynolds, C., Rezzolla, L., Ribo, M., de la Rie, R., Riggio, A., Rios, A., Rischke, D., Rodríguez Gil, P., Rodriguez, J., Rohlfs, R., Romano, P., Rossi, E., Rozanska, A., Rousseau, A., Rudak, B., Russell, D., Ryde, F., Sabau Graziati, L., Sakamoto, T., Sala, G., Salvaterra, R., Salvetti, D., Sanna, A., Sandberg, J., Savolainen, T., Scaringi, S., Schaffner Bielich, J., Schatz, H., Schee, J., Schmid, C., Serino, M., Shakura, N., Shore, S., Schnittman, J., Schneider, R., Schwenk, A., Schwope, A., Sedrakian, A., Seyler, J., Shearer, A., Slowikowska, A., Sims, M., Smith, A., Smith, D., Smith, P., Sobolewska, M., Sochora, V., Soffitta, P., Soleri, P., Song, L., Spencer, A., Stamerra, A., Stappers, B., Staubert, R., Steiner, A., Stergioulas, N., Stevens, A., Stratta, G., Strohmayer, T., Stuchlik, Z., Suchy, S., Suleimanov, V., Tamburini, F., Tauris, T., Tavecchio, F., Tenzer, C., Thielemann, F., Tiengo, A., Tolos, L., Tombesi, F., Tomsick, J., Torok, G., Torrejon, J., Torres, D., Torresi, E., Tramacere, A., Traulsen, I., Trois, A., Turolla, R., Turriziani, S., Typel, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vietri, M., Vincent, F., Vrba, V., Walton, D., Wang, J., Wang, Z., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson Hodge, C., Winter, B., Walk, S., Wood, K., Woosley, S., Wu, X., Xu, R., Yu, W., Yuan, F., Yuan, W., Yuan, Y., Zampa, G., Zampa, N., Zampieri, L., Zdunik, L., Zdziarski, A., Zech, A., Zhang, B., Zhang, C., Zingale, M., Zwart, F., University of Geneva [Switzerland], Eberhard Karls Universität Tübingen, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Graduate School of the Natural Science and Technology, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), School of BioSciences [Melbourne], University of Melbourne-University of Melbourne-Royal Melbourne Institute of Technology University (RMIT University)-University of Queensland [Brisbane]-Australian National University (ANU)-The University of Western Australia (UWA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National d’Études Spatiales [Paris] (CNES), Université Libre de Bruxelles [Bruxelles] (ULB), Dublin City University, Dublin 9, Ireland, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), China Information Technology Security Evaluation Center, Technical University of Denmark [Lyngby] (DTU), Université Grenoble Alpes (UGA), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Trieste, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Intégrative de la Cellule (I2BC), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Università degli Studi di Roma 'La Sapienza' [Rome], Radboud university [Nijmegen]-Radboud university [Nijmegen], Radboud university [Nijmegen], Universidad de Granada (UGR), Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Catania [Catania], Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Université du Littoral Côte d'Opale, Stanford University [Stanford], Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Università degli studi di Napoli Federico II, IFP Energies nouvelles (IFPEN), National Institute for Nuclear Physics (INFN), Institut Jean Le Rond d'Alembert (DALEMBERT), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), Ingénierie des Matériaux Polymères (IMP), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centro Euro-Mediterraneo per i Cambiamenti Climatici (CMCC), Universität Heidelberg [Heidelberg], Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Università di Bologna [Bologna] (UNIBO), University of California [Berkeley], University of California-University of California, Universita degli Studi di Padova, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Chalmers University of Technology [Göteborg], Astronomy, Jan-Willem A. den Herder, Shouleh Nikzad, Kazuhiro Nakazawa, Van Der Klis, M., Liu, L. -P., Zhang, S. -N., Atteia, J. -L., Ballantyne, D. R., Van Baren, C., Bellutti, P., Bonnet Bidaud, J. -M., Borghi, G., Briggs, M. S., Budtz-Jorgensen, C., Cadoux, F. R., Caliandro, G. A., Castro-Tirado, A. J., Cerda-Duran, P., Chateau, F., D'Ai, A., Dercksen, J. P. C., Den Herder, J. W., Di Salvo, T., Drake, S. A., Erkut, M. H., Ficorella, F., Finger, M. H., Fraser, G. W., Galloway, D. K., Galvez Sanchez, J. L., Garcia-Berro, E., Giles, A. B., Goluchova, K., Gotz, D., Hartmann, D. H., Haswell, C. A., Inam, S. C., In'Tzand, J. J. M., Jacobs, H. M., Jenke, P. A., Jose, J., Kalamkar, M., Kowalski, A. F., Kuiper, L. M., Lamb, F. K., Laubert, P. P., Maccarone, T. J., Markoff, S. B., Martinez, G., Mchardy, I. M., Medina-Tanco, G., Miller, M. C., Miller, J. M., Mulacova, J., Munoz-Darias, T., Norton, A. J., Olsen, P. E. H., Osborne, J. P., Paredes, J. M., Penacchioni, A. V., Perez, M. A., Perez-Torres, M., Peterson, B. M., Picciotto, A., Piemonte, C., Rachevski, A., Ray, P. S., De La Rie, R., Rischke, D. H., Rodriguez-Gil, P., Rossi, E. M. R., Russell, D. M., Sabau-Graziati, L., Schaffner-Bielich, J., Schnittman, J. D., Schwope, A. D., Seyler, J. -Y., Smith, D. M., Smith, P. J., Steiner, A. W., Stevens, A. L., Strohmayer, T. E., Thielemann, F. K., Torrejon, J. M., Torres, D. F., Vincent, F. H., Wilson-Hodge, C. A., Walk, S. J., Woosley, S. E., Xiao, L., Zorzi, N., Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Department of Psychiatry (Icahn School of Medicine at Mount Sinai) ( ISMMS ), Rutgers, The State University of New Jersey [New Brunswick] ( RUTGERS ), Institut fur Astronomie und Astrophysik, Astrophysique Interactions Multi-échelles ( AIM - UMR 7158 - UMR E 9005 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ), Kanazawa University ( KU ), Department of Earth Sciences, University of Oxford [Oxford], Centre Interdisciplinaire de Nanoscience de Marseille ( CINaM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Tampere University of Technology [Tampere] ( TUT ), University of Southern Mississippi ( USM ), University of Southampton [Southampton], Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano ( IASF-MI ), Istituto Nazionale di Astrofisica ( INAF ), Istituto di Astrofisica e Planetologia Spaziali ( IAPS ), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées ( LATT ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Swedish Institute of Space Physics [Uppsala] ( IRF ), Osservatorio Astronomico di Brera ( INAF ), Bibliothèque nationale de France ( BnF ), Istituto di Astrofisica Spaziale e Fisica cosmica - Palermo ( IASF-Pa ), ARC Centre of Excellence for Environmental Decisions ( ARC CEED ), The University of Western Australia ( UWA ) -Australian National University ( ANU ) -University of Queensland [Brisbane]-RMIT University [Melbourne]-University of Melbourne, ARC Centre of Excellence for Coral Reef Studies ( CoralCoE ), James Cook University ( JCU ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Anthropologie Moléculaire et Imagerie de Synthèse ( AMIS ), PRES Université de Toulouse-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de synthèse organique ( DCSO ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Pathology, University of Alabama at Birmingham, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, INAF-Osservatorio di Cagliari, Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Théorique et Modèles Statistiques ( LPTMS ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace ( LPC2E ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Université Libre de Bruxelles [Bruxelles] ( ULB ), Ocean and Earth Sciences, National Oceanography Centre Southampton, Dublin Institute for advanced studies, 31 Fitzwilliam Place, Dublin 2, Ireland, Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), Institut Parisien de Chimie Moléculaire ( IPCM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Beijing] ( CAS ), Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Applied Mathematics and Computer Science [Lyngby] ( DTU Compute ), Technical University of Denmark [Lyngby] ( DTU ), Institut für Astronomie und Astrophysik ( IAAT ), Anton Pannekoek Institute for Astronomy, University of Amsterdam, University of Cambridge [UK] ( CAM ), International Space Science Institute ( ISSI ), Université Grenoble Alpes - UFR Médecine ( UGA UFRM ), Université Grenoble Alpes ( UGA ), Institute of Perception, Action and Behaviour ( IPAB ), United States Geological Survey [Reston] ( USGS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Max-Planck-Institut für Extraterrestrische Physik ( MPE ), Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology ( MIT ), Institut de Physique du Globe de Paris ( IPGP ), Institut national des sciences de l'Univers ( INSU - CNRS ) -IPG PARIS-Université Paris Diderot - Paris 7 ( UPD7 ) -Université de la Réunion ( UR ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Biologie Intégrative de la Cellule ( I2BC ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), University of Wisconsin-Madison [Madison], SRON Netherlands Institute for Space Research ( SRON ), University of Technology ( Opole ), Institute for Mathematics, Astrophysics and Particle Physics ( IMAPP ), Grp Fis Atmosfera, Ctr Andaluz Medio Ambiente CEAMA, Universidad de Granada ( UGR ), The Hong Kong Polytechnic University [Hong Kong] ( POLYU ), Chinese Academy of Sciences [Changchun Branch] ( CAS ), Department of Physics, Chemistry and Biology, Linköping University ( LIU ), Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique Nucléaire de Lyon ( IPNL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Astronomical Institute Anton Pannekoek ( AI PANNEKOEK ), University of Amsterdam [Amsterdam] ( UvA ), Erlangen Centre for Astroparticle Physics ( ECAP ), Friedrich-Alexander Universität Erlangen-Nürnberg ( FAU ), Centre de recherches de biochimie macromoléculaire ( CRBM ), Université Montpellier 1 ( UM1 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Instituto Nacional de Pesquisas da Amazônia ( INPA ), Instituto Nacional de Pesquisas da Amazônia, Centre d'Ecologie et des Sciences de la COnservation ( CESCO ), Muséum National d'Histoire Naturelle ( MNHN ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Ecologie Alpine ( LECA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie de l'Atmosphère ( LPCA ), Université du Littoral Côte d'Opale-Centre National de la Recherche Scientifique ( CNRS ), Institut des Sciences Moléculaires de Marseille ( ISM2 ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), Space Telescope Science Institute ( STSci ), IFP Energies nouvelles ( IFPEN ), Laboratoire de Biométrie et Biologie Evolutive ( LBBE ), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ), University of Arkansas, Istituto Nazionale di Fisica Nucleare, Sezione di Trieste ( INFN, Sezione di Trieste ), National Institute for Nuclear Physics ( INFN ), Institut Jean Le Rond d'Alembert ( DALEMBERT ), Institut de Ciencies de l'Espai [Barcelona] ( ICE-CSIC ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), University of Reading ( UOR ), Universidade de Santiago de Compostela, Équipe Robotique et InteractionS ( LAAS-RIS ), Laboratoire d'analyse et d'architecture des systèmes [Toulouse] ( LAAS ), Institut National Polytechnique [Toulouse] ( INP ) -Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National Polytechnique [Toulouse] ( INP ) -Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Ingénierie des Matériaux Polymères - Site INSA Lyon ( IMP ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre National de la Recherche Scientifique ( CNRS ), Leibniz-Institut für Astrophysik Potsdam ( AIP ), Daimler Chrysler AG ( Daimler ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Montserrat Volcano Observatory ( MVO ), Institut Armand Frappier ( INRS-IAF ), Institut National de la Recherche Scientifique [Québec] ( INRS ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut Armand Frappier, Università di Bologna [Bologna] ( UNIBO ), Max-Planck-Institut für Radioastronomie, Argelander Institut für Astronomie, Bonn Universität [Bonn], Space Sciences Laboratory [Berkeley] ( SSL ), Christian-Albrechts-Universität zu Kiel ( CAU ), Universita degli Studi di Padova = University of Padua = Université de Padoue, APC - Gravitation ( APC-Gravitation ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Max-Planck-Institut-Max-Planck-Institut, California Institute of Technology ( CALTECH ), Mitsubishi Electric Research Laboratories ( MERL ), Mitsubishi Electric Research Laboratories, Institute for Astronomy, University of Amsterdam, The Netherland, University of Southern California ( USC ), National University of Defense Technology [Changsha], Department of Microtechnology and Nanoscience ( MC2 ), Université Chalmers, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Nice Sophia Antipolis (UNS), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Den Herder, Jan-Willem A., Bautz, M., den Herder, Jan-Willem A., Takahashi, Tadayuki, Bautz, Marshall, Jan-Willem A. den Herder, Tadayuki Takahashi, Marshall Bautz, Liu, L. P., Zhang, S. N., Atteia, J. L., Bonnet Bidaud, J. M., Castro Tirado, A. J., D'Aı, A., den Herder, J. W., Gálvez Sanchez, J. L., In't Zand, J. J. M., Nucita, Achille, Seyler, J. Y., Wilson Hodge, C. A., Baldazzi, Giuseppe, Fuschino, Fabio, Bianchi, Stefano, Casella, Piergiorgio, DE ROSA, Alessandra, Giovannini, Gabriele, LA FRANCA, Fabio, Marinucci, Andrea, Paredes, M. J., Schneider, Raffaella, Vietri, Mario, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), M., Feroci, E., Bozzo, S., Brandt, M., Hernanz, M., van der Kli, L. P., Liu, P., Orleanski, M., Pohl, A., Santangelo, S., Schanne, L., Stella, T., Takahashi, H., Tamura, A., Watt, J., Wilm, S., Zane, S. N., Zhang, S., Bhattacharyya, I., Agudo, M., Ahangarianabhari, C., Albertu, M., Alford, A., Alpar, D., Altamirano, L., Alvarez, L., Amati, C., Amoro, N., Andersson, A., Antonelli, A., Argan, R., Artigue, B., Artigue, J. L., Atteia, P., Azzarello, P., Bakala, D., Ballantyne, G., Baldazzi, M., Baldo, S., Balman, M., Barbera, C., van Baren, D., Barret, A., Baykal, M., Begelman, E., Behar, O., Behar, T., Belloni, F., Bernardini, G., Bertuccio, S., Bianchi, A., Bianchini, P., Binko, P., Blay, F., Bocchino, M., Bode, P., Bodin, I., Bombaci, J. M., Bonnet Bidaud, S., Boutlouko, F., Bouyjou, L., Bradley, J., Braga, M. S., Brigg, E., Brown, M., Buballa, N., Bucciantini, L., Burderi, M., Burgay, M., Bursa, C., Budtz Jørgensen, E., Cackett, F., Cadoux, P., Cai, G. A., Caliandro, R., Campana, S., Campana, X., Cao, F., Capitanio, J., Casare, P., Casella, A. J., Castro Tirado, E., Cavazzuti, Y., Cavechi, S., Celestin, P., Cerda Duran, D., Chakrabarty, N., Chamel, F., Château, C., Chen, Y., Chen, J., Chenevez, M., Chernyakova, J., Coker, R., Cole, A., Collura, M., Coriat, R., Cornelisse, L., Costamante, A., Cro, W., Cui, A., Cumming, G., Cusumano, B., Czerny, A., D'Aì, F., D'Ammando, V., D'Elia, Z., Dai, E., Del Monte, A., De Luca, D., De Martino, J. P. C., Dercksen, M., De Pasquale, A., De Rosa, M., Del Santo, S., Di Cosimo, N., Degenaar, J. W., den Herder, S., Diebold, T., Di Salvo, Y., Dong, I., Donnarumma, V., Doroshenko, G., Doyle, S. A., Drake, M., Durant, D., Emmanoulopoulo, T., Enoto, M. H., Erkut, P., Esposito, Y., Evangelista, A., Fabian, M., Falanga, Y., Favre, C., Feldman, R., Fender, H., Feng, V., Ferrari, C., Ferrigno, M., Finger, M. H., Finger, G. W., Fraser, M., Frerick, M., Fullekrug, F., Fuschino, M., Gabler, D. K., Galloway, J. L., Gálvez Sanchez, P., Gandhi, Z., Gao, E., Garcia Berro, B., Gendre, O., Gevin, S., Gezari, A. B., Gile, M., Gilfanov, P., Giommi, G., Giovannini, M., Giroletti, E., Gogu, A., Goldwurm, K., Goluchová, D., Götz, L., Gou, C., Gouiffe, P., Grandi, M., Grassi, J., Greiner, V., Grinberg, P., Groot, M., Gschwender, L., Gualtieri, M., Guedel, C., Guidorzi, L., Guy, D., Haa, P., Haensel, M., Hailey, K., Hamuguchi, F., Hansen, D. H., Hartmann, C. A., Haswell, K., Hebeler, A., Heger, M., Hempel, W., Hermsen, J., Homan, A., Hornstrup, R., Hudec, J., Huovelin, D., Huppenkothen, S. C., Inam, A., Ingram, J. J. M., In't Zand, G., Israel, K., Iwasawa, L., Izzo, H. M., Jacob, F., Jetter, T., Johannsen, P. A., Jenke, P., Jonker, J., Josè, P., Kaaret, K., Kalamkar, E., Kalemci, G., Kanbach, V., Kara, D., Karelin, D., Kataria, L., Keek, T., Kennedy, D., Klochkov, W., Kluzniak, E., Koerding, K., Kokkota, S., Komossa, S., Korpela, C., Kouveliotou, A. F., Kowalski, I., Kreykenbohm, L. M., Kuiper, D., Kunneriath, A., Kurkela, I., Kuvvetli, F., La Franca, C., Labanti, D., Lai, F. K., Lamb, C., Lachaud, P. P., Laubert, F., Lebrun, X., Li, E., Liang, O., Limousin, D., Lin, M., Linare, D., Linder, G., Lodato, F., Longo, F., Lu, N., Lund, T. J., Maccarone, D., Macera, S., Maestre, S., Mahmoodifar, D., Maier, P., Malcovati, J., Malzac, C., Malone, I., Mandel, V., Mangano, A., Manousaki, M., Marelli, J., Margueron, M., Marisaldi, S. B., Markoff, A., Markowitz, A., Marinucci, A., Martindale, G., Martínez, I. M., Mchardy, G., Medina Tanco, M., Mehdipour, A., Melato, M., Mendez, S., Mereghetti, S., Migliari, R., Mignani, M., Michalska, T., Mihara, M. C., Miller, J. M., Miller, T., Mineo, G., Miniutti, S., Morsink, C., Motch, S., Motta, M., Mouchet, G., Mouret, J., Mulačová, F., Muleri, T., Muñoz Daria, I., Negueruela, J., Neilsen, T., Neubert, A. J., Norton, M., Nowak, A., Nucita, P., O'Brien, M., Oertel, P. E. H., Olsen, M., Orienti, M., Orio, M., Orlandini, J. P., Osborne, R., Osten, F., Ozel, L., Pacciani, F., Paerel, S., Paltani, Paolillo, Maurizio, I., Papadaki, A., Papitto, Z., Paragi, J. M., Parede, A., Patruno, B., Paul, F., Pederiva, E., Perinati, A., Pellizzoni, A. V., Penacchioni, U., Peretz, M. A., Perez, M., Perez Torre, B. M., Peterson, V., Petracek, C., Pittori, J., Pon, J., Portell, A., Possenti, K., Postnov, J., Poutanen, M., Prakash, I., Prandoni, H., Le Provost, D., Psalti, J., Pye, J., Qu, D., Rambaud, P., Ramon, G., Ramsay, M., Rapisarda, A., Rashevski, I., Rashevskaya, P. S., Ray, N., Rea, S., Reddy, P., Reig, M., Reina Aranda, R., Remillard, C., Reynold, L., Rezzolla, M., Ribo, R., de la Rie, A., Riggio, A., Rio, D. H., Rischke, P., Rodríguez Gil, J., Rodriguez, R., Rohlf, P., Romano, E. M. R., Rossi, A., Rozanska, A., Rousseau, B., Rudak, D. M., Russell, F., Ryde, L., Sabau Graziati, T., Sakamoto, G., Sala, R., Salvaterra, D., Salvetti, A., Sanna, J., Sandberg, T., Savolainen, S., Scaringi, J., Schaffner Bielich, H., Schatz, J., Schee, C., Schmid, M., Serino, N., Shakura, S., Shore, J. D., Schnittman, R., Schneider, A., Schwenk, A. D., Schwope, A., Sedrakian, J. Y., Seyler, A., Shearer, A., Slowikowska, M., Sim, A., Smith, D. M., Smith, P. J., Smith, M., Sobolewska, V., Sochora, P., Soffitta, P., Soleri, L., Song, A., Spencer, A., Stamerra, B., Stapper, R., Staubert, A. W., Steiner, N., Stergioula, A. L., Steven, G., Stratta, T. E., Strohmayer, Z., Stuchlik, S., Suchy, V., Suleimanov, F., Tamburini, T., Tauri, F., Tavecchio, C., Tenzer, F. K., Thielemann, A., Tiengo, L., Tolo, F., Tombesi, J., Tomsick, G., Torok, J. M., Torrejon, D. F., Torre, E., Torresi, A., Tramacere, I., Traulsen, A., Troi, R., Turolla, S., Turriziani, S., Typel, P., Uter, P., Uttley, A., Vacchi, P., Varniere, S., Vaughan, S., Vercellone, M., Vietri, F. H., Vincent, V., Vrba, D., Walton, J., Wang, Z., Wang, S., Watanabe, R., Wawrzaszek, N., Webb, N., Weinberg, H., Wende, P., Wheatley, R., Wijer, R., Wijnand, M., Wille, C. A., Wilson Hodge, B., Winter, S. J., Walk, K., Wood, S. E., Woosley, X., Wu, R., Xu, W., Yu, F., Yuan, W., Yuan, Y., Yuan, G., Zampa, N., Zampa, L., Zampieri, L., Zdunik, A., Zdziarski, A., Zech, B., Zhang, C., Zhang, S., Zhang, M., Zingale, and F., Zwart

Subjects
X-ray timing, [ SDU.ASTR.GA ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Field of view, Astrophysics, 01 natural sciences, law.invention, law, Observatory, timing, 010303 astronomy & astrophysics, QB, Physics, microchannel plates. PROPORTIONAL COUNTER ARRAY, CALIBRATION, X-ray astronomy, Electronic, Optical and Magnetic Material, Applied Mathematics, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications1707 Computer Vision and Pattern Recognition, X-ray detectors, Condensed Matter Physics, compact objects, X-ray spectroscopy, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], spectroscopy, Cosmic Vision, [ INFO ] Computer Science [cs], Silicon detector, Astrophysics::High Energy Astrophysical Phenomena, Condensed Matter Physic, Telescope, X-ray, Silicon detectors, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Electronic, [INFO]Computer Science [cs], Optical and Magnetic Materials, Spectral resolution, DETECTOR, ta115, X-ray astronomy, Silicon detectors, timing, spectroscopy, 010308 nuclear & particles physics, X-ray imaging, Applied Mathematic, Neutron star, QB460-466 Astrophysics, Large Observatory For x-ray Timing (LOFT), Large Area Detector (LAD), Wide Field Monitor (WFM), Large Area Silicon Drift Detectors (SDD), Gamma-ray burst
Abstract

The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, >8m2 effective area, 2-30 keV, 240 eV spectral resolution, 1 degree collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g., GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the current technical and programmatic status of the mission. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Published
2016
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265. Trends in cause-specific mortality among persons with Alzheimer's disease in South Carolina: 2014 to 2019.

Author

Brown CS, Ning X, Money A, Alford M, Pan Y, Miller M, and Lohman M

Abstract

Introduction: Inconsistencies of reports contributes to the underreporting of Alzheimer's disease (AD) on death certificates. Whether underreporting exists within South Carolina has not been studied., Methods: We conducted a prospective, population-based study on a cohort of persons ( N  = 78,534) previously diagnosed with AD and died between 2014-2019. We linked vital records with the South Carolina Alzheimer's Disease and Related Dementias Registry to investigate their cause of death and survival rates. Descriptive analyses calculated frequencies of demographic and health-related characteristics. Turnbull's method estimated the survival probabilities for different subgroups of patients. Hazard ratios were computed from the Cox proportional hazards model, adjusting for the following confounding variables of age at diagnosis, education level, gender, and race., Results: The top immediate cause of death was Alzheimer's disease among all racial groups, except for Native American/American Indian. More females (60.3%) were affected by AD compared to males (39.7%). There is a 25% probability of survival, beyond 5 years, after AD diagnosis. Black/African American AD patients have the smallest risk of all-cause mortality across all racial/ethnic groups (HR 0.87; 95% CI, 0.85-0.89). Individuals with lower education had a lower likelihood of mortality., Conclusion: Although AD was not underreported in the state of South Carolina further research is needed to develop protocols around classification of deaths among those diagnosed with dementia and comorbidities, including cardiovascular disease, to ensure dementia is properly reported as we move to prevent and treat Alzheimer's disease by 2025 and beyond., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Brown, Ning, Money, Alford, Pan, Miller and Lohman.)

Published
2024
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268. Governance and Power Across Intersecting Value Chains: The Case of South African Apples.

Author

Visser M and Alford M

Abstract

A prevailing focus of global value chain (GVC) analysis has been on the dominance of highly consolidated Northern retailers over suppliers in the global South. The rise of regional and domestic value chains (RVCs/DVCs) within the Global South which intersect with GVCs, has been found to involve private governance by Southern lead firms. However, we have limited insight into the implications of this changing value chain context for the role of public governance, or different groups of workers. South African fruit provides a rich example of rapid shifts in RVCs/DVCs governed by different private and public actors. The following two questions are addressed: How is the public-private governance of labour standards evolving in the context of RVCs and DVCs that intersect with GVCs? What are the implications for workers operating across different value chains? Conceptually, the paper draws on GVC analysis of governance and power, to examine the governance of labour standards across intersecting value chains. Our analysis highlights the intentional and unintentional mechanisms through which power and standard-setting are diffused away from Northern lead firms to a wider array of public and private actors operating across RVCs/DVCs. While existing analysis of governance and power focuses on singular GVCs, our study highlights diffusion of power across intersecting value chains, with significant and uneven implications for the public-private governance of labour standards. Our findings carry significant ethical implications for the governance of labour standards, as end-markets continue to shift South., Competing Interests: Conflict of interestThe authors have no competing interests to declare that are relevant to the content of this article., (© The Author(s) 2023.)

Published
2023
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269. The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species.

Author

Wiesmann CL, Zhang Y, Alford M, Hamilton CD, Dosanjh M, Thoms D, Dostert M, Wilson A, Pletzer D, Hancock REW, and Haney CH

Subjects
Animals, Mice, Pseudomonas aeruginosa, Plants microbiology, Pseudomonas genetics, Pseudomonas fluorescens genetics
Abstract

Members of the bacterial genus Pseudomonas form mutualistic, commensal, and pathogenic associations with diverse hosts. The prevalence of host association across the genus suggests that symbiosis may be a conserved ancestral trait and that distinct symbiotic lifestyles may be more recently evolved. Here we show that the ColR/S two-component system, part of the Pseudomonas core genome, is functionally conserved between Pseudomonas aeruginosa and Pseudomonas fluorescens. Using plant rhizosphere colonization and virulence in a murine abscess model, we show that colR is required for commensalism with plants and virulence in animals. Comparative transcriptomics revealed that the ColR regulon has diverged between P. aeruginosa and P. fluorescens and deleting components of the ColR regulon revealed strain-specific, but not host-specific, requirements for ColR-dependent genes. Collectively, our results suggest that ColR/S allows Pseudomonas to sense and respond to a host, but that the ColR-regulon has diverged between Pseudomonas strains with distinct lifestyles. This suggests that conservation of two-component systems, coupled with life-style dependent diversification of the regulon, may play a role in host association and lifestyle transitions., (© 2022. The Author(s), under exclusive licence to International Society for Microbial Ecology.)

Published
2023
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270. Remote neuropsychological assessment: Acceptability and feasibility of direct-to-home teleneuropsychology methodology during the COVID-19 pandemic.

Author

Sumpter R, Camsey E, Meldrum S, Alford M, Campbell I, Bois C, O'Connell S, and Flood J

Subjects
Humans, Pandemics, State Medicine, Feasibility Studies, Neuropsychological Tests, Communicable Disease Control, COVID-19 epidemiology
Abstract

Objective: To determine the acceptability and feasibility of telephone and video-conference calls to complete cognitive assessments during the COVID-19 pandemic., Method: In rapid response to the pandemic, evidence-based adaptations were made to routine face-to-face (FTF) practice, delivering teleneuropsychology (TNP) within a National Health Service (NHS) Scotland neuropsychology service. Caldicott guardian approval was obtained to complete a six month study (April to October 2020) from the early stages of the first United Kingdom (UK) lockdown. Assessments were completed with patients in their own homes (direct-to-home) via remote connections. Neuropsychology clinicians, service-users and referring agents were approached for structured feedback and qualitative comment., Results: Data was captured for 212 referrals assessed by seven clinical psychologists; with responses from 70 (33%) service-users and 14 (58%) referring agents. 94% of referrals were assessed remotely and discharged. TNP reduced defaulted appointment discharge rates. Gender, socioeconomic deprivation and age did not affect access to information technology (IT) equipment.Clinicians agreed that remote assessment allowed them to complete initial interview (96%) and formulate (77%) cases appropriately. Service-users agreed they were comfortable with equipment (84%), the process was straightforward (74%), and would recommend TNP to others (68%). Referring agents were satisfied with the service provided (100%). Limitations included evidence-based remote test availability, technical issues and home distractions., Conclusions: Study findings evidence the acceptability and efficiency of TNP; increasing service accessibility, while reducing infection risk, defaulted appointments and travel. The results advocate for a post-pandemic mixed model of service delivery encompassing both FTF and TNP approaches.

Published
2023
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271. Demographic and Glycemic Factors Linked With Diabetes Distress in Teens With Type 1 Diabetes.

Author

Inverso H, LeStourgeon LM, Parmar A, Bhangui I, Hughes B, Straton E, Alford M, Streisand R, and Jaser SS

Subjects
Adolescent, Blood Glucose, Emotions, Ethnicity, Female, Glycated Hemoglobin, Humans, Male, Diabetes Mellitus, Type 1 psychology
Abstract

Objective: Diabetes distress (DD) is a negative emotional response related to the burdens of living with type 1 diabetes (T1D) and is linked with diabetes outcomes, such as hemoglobin A1c (A1c). Yet, less is known about how other glycemic indicators, average blood glucose and time in range, relate to DD, and which demographic characteristics are associated with higher DD., Methods: In total, 369 teens (Mage 15.6 ± 1.4, 51% female, MT1D duration 6.7 ± 3.8 years) screened for DD using The Problem Areas in Diabetes-Teen Version to determine eligibility for an ongoing multi-site behavioral trial. The associations of DD, demographic factors, and glycemic indicators (A1c, average blood glucose, and time in range) were analyzed., Results: Twenty-nine percent of teens (n = 95) scored above the clinical cutoff (≥44) for DD. Females scored significantly higher on average than males. Black/African American, non-Hispanic youth screened significantly higher compared to youth from other racial/ethnic groups. Higher DD scores were related to higher A1c and average blood glucose, and lower time in range. Logistic regression models revealed that females were significantly more likely to report clinically elevated DD than males, and teens with higher A1c were 1.3 times more likely to report DD. Age and diabetes duration were not significantly associated with clinically elevated DD scores., Conclusions: Results demonstrated that DD is most prevalent in Black, non-Hispanic and female teens, and DD is associated with higher average blood glucose and lower time in range. Further investigation into these disparities is warranted to promote optimal health outcomes for teens with T1D., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2022
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273. Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response.

Author

Etayash H, Alford M, Akhoundsadegh N, Drayton M, Straus SK, and Hancock REW

Subjects
Humans, Methicillin-Resistant Staphylococcus aureus drug effects, Microbial Sensitivity Tests, Staphylococcus epidermidis drug effects, Anti-Bacterial Agents pharmacology, Antimicrobial Cationic Peptides pharmacology, Bacteria drug effects, Biofilms drug effects, Immunity, Innate drug effects
Abstract

Effective anti-infective therapies are required to offset the rise in antibiotic resistance. A novel vancomycin-innate defense regulator conjugate (V-IDR1018) was constructed with multimodal functionality, including bacterial killing, biofilm eradication, and immune modulation. The conjugate killed bacteria within 30 min, exhibited potent activity against persister cells, and showed no susceptibility to antimicrobial resistance in tissue culture assays. Additionally, it stimulated the release of chemokine MCP-1 and anti-inflammatory cytokine IL-10 and suppressed pro-inflammatory IL-1β from lipopolysaccharide-stimulated white blood cells. The conjugate demonstrated ∼90% eradication efficacy when assessed against the MRSA biofilm formed on an organoid human skin equivalent. Similarly, when evaluated in a murine, high-density skin abscess infection model using MRSA or Staphylococcus epidermidis , the conjugate decreased dermonecrosis and reduced bacterial load. The exceptional in vitro and in vivo efficacy of the conjugate, in addition to its safety profile, makes it a valuable candidate to treat complex infectious diseases.

Published
2021
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274. Evaluating the Clinical Impact of National Dementia Behaviour Support Programs on Neuropsychiatric Outcomes in Australia.

Author

Macfarlane S, Atee M, Morris T, Whiting D, Healy M, Alford M, and Cunningham C

Abstract

Background/Objective: People living with dementia (PLWD) in residential aged care homes (RACHs) are frequently prescribed psychotropic medications due to the high prevalence of neuropsychiatric symptoms, also known as behaviours and psychological symptoms of dementia (BPSD). However, the gold standard to support BPSD is using psychosocial/non-pharmacological therapies. This study aims to describe and evaluate services and neuropsychiatric outcomes associated with the provision of psychosocial person-centred care interventions delivered by national multidisciplinary dementia-specific behaviour support programs. Methods: A 2-year retrospective pre-post study with a single-arm analysis was conducted on BPSD referrals received from Australian RACHs to the two Dementia Support Australia (DSA) programs, the Dementia Behaviour Management Advisory Service (DBMAS) and the Severe Behaviour Response Teams (SBRT). Neuropsychiatric outcomes were measured using the Neuropsychiatric Inventory (NPI) total scores and total distress scores. The questionnaire version "NPI-Q" was administered for DBMAS referrals whereas the nursing home version "NPI-NH" was administered for SBRT referrals. Linear mixed effects models were used for analysis, with time, baseline score, age, sex, and case length as predictors. Clinical significance was measured using Cohen's effect size ( d ; ≥0.3), the mean change score (MCS; 3 points for the NPI-Q and 4 points for the NPI-NH) and the mean percent change (MPC; ≥30%) in NPI parameters. Results: A total of 5,914 referrals (55.9% female, age 82.3 ± 8.6 y) from 1,996 RACHs were eligible for analysis. The most common types of dementia were Alzheimer's disease (37.4%) and vascular dementia (11.7%). The average case length in DSA programs was 57.2 ± 26.3 days. The NPI scores were significantly reduced as a result of DSA programs, independent of covariates. There were significant reductions in total NPI scores as a result of the DBMAS (61.4%) and SBRT (74.3%) programs. For NPI distress scores, there were 66.5% and 69.1% reductions from baseline for the DBMAS and SBRT programs, respectively. All metrics ( d , MCS, MPC) were above the threshold set for determining a clinically significant effect. Conclusions: Multimodal psychosocial interventions delivered by DSA programs are clinically effective as demonstrated by positive referral outcomes, such as improved BPSD and related caregiver distress., Competing Interests: The authors are staff members of The Dementia Centre; a research, education, and consultancy arm of HammondCare, an independent Christian charity which auspices the DSA programs – DBMAS and SBRT. SM is the Head of Clinical Services for The Dementia Centre, HammondCare. MAl is the Head of Business Development, HammondCare. CC is the Director of The Dementia Centre, HammondCare., (Copyright © 2021 Macfarlane, Atee, Morris, Whiting, Healy, Alford and Cunningham.)

Published
2021
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275. COVID-19 and the case for global development.

Author

Oldekop JA, Horner R, Hulme D, Adhikari R, Agarwal B, Alford M, Bakewell O, Banks N, Barrientos S, Bastia T, Bebbington AJ, Das U, Dimova R, Duncombe R, Enns C, Fielding D, Foster C, Foster T, Frederiksen T, Gao P, Gillespie T, Heeks R, Hickey S, Hess M, Jepson N, Karamchedu A, Kothari U, Krishnan A, Lavers T, Mamman A, Mitlin D, Monazam Tabrizi N, Müller TR, Nadvi K, Pasquali G, Pritchard R, Pruce K, Rees C, Renken J, Savoia A, Schindler S, Surmeier A, Tampubolon G, Tyce M, Unnikrishnan V, and Zhang YF

Abstract

COVID-19 accentuates the case for a global, rather than an international, development paradigm. The novel disease is a prime example of a development challenge for all countries, through the failure of public health as a global public good. The COVID-19 pandemic has highlighted the falsity of any assumption that the global North has all the expertise and solutions to tackle global challenges, and has further highlighted the need for multi-directional learning and transformation in all countries towards a more sustainable and equitable world. We illustrate our argument for a global development paradigm by examining the implications of the COVID-19 pandemic across four themes or 'vignettes': global value chains, digitalisation, debt, and climate change. We conclude that development studies must adapt to a very different context from when the field emerged in the mid-20th century., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2020 Elsevier Ltd. All rights reserved.)

Published
2020
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276. Management of Orbital Floor Fractures.

Author

Shokri T, Alford M, Hammons M, Ducic Y, and Sokoya M

Subjects
Eye Movements, Facial Bones injuries, Humans, Retrospective Studies, Orbital Fractures surgery
Abstract

Fractures of the orbital floor represent a common yet difficult to manage sequelae of craniomaxillofacial trauma. Repair of these injuries should be carried out with the goal of restoring normal orbital volume, facial contour, and ocular motility. Precise surgical repair is imperative to reduce the risk of long-term debilitating morbidity. This article aims to review concepts on the management of orbital floor fractures in the hope of further elucidating perioperative evaluation and decision-making regarding operative intervention., Competing Interests: None., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)

Published
2019
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277. Role of endonuclease III enzymes in uracil repair.

Author

Yang Y, Park SH, Alford-Zappala M, Lee HW, Li J, Cunningham RP, and Cao W

Subjects
DNA Repair, Deamination, Humans, Uracil-DNA Glycosidase metabolism, DNA, Bacterial metabolism, Deoxyribonuclease (Pyrimidine Dimer) metabolism, Escherichia coli Proteins metabolism, Uracil metabolism
Abstract

Endonuclease III is a DNA glycosylase previously known for its repair activity on oxidative pyrimidine damage. Uracil is a deamination product derived from cytosine. Uracil DNA N-glycosylase (UNG) and mismatch-specific uracil DNA glycosylase (MUG) are two known repair enzymes with enzymatic activity on uracil in E. coli. Here we report a G/U specific uracil DNA glycosylase activity in E. coli endonuclease III (endo III, Nth), which is comparable to MUG but significantly lower than its thymine glycol DNA glycosylase activity. The possibility that the novel activity is due to contamination is ruled out by expressing the wild type nth gene and an active site mutant in a uracil-repair-deficient genetic background. Consistent with the biochemical analysis, analyses of lac +  reversion and mutation frequencies in the presence of human AID induced cytosine deamination indicate the endo III can play a role in repair of cytosine deamination. In addition to E. coli, UDG activity is found in endo III homologs from other organisms. E. coli nucleoside diphosphate kinase (Ndk) was also tested for UDG activity because it was previously reported as an uracil repair enzyme. Under the assay conditions, very limited UDG activity was detected in single-stranded uracil-containing DNA from E. coli Ndk and no UDG activity was detected in human Ndk homologs. This study provides definitive clarification on uracil repair by endo III and reveals that endonuclease III is a G/U-specific UDG that can be viewed as a prototype for the human MBD4 uracil DNA glycosylase., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2019
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278. Augmenting Buried in Treasures with in-home uncluttering practice: Pilot study in hoarding disorder.

Author

Linkovski O, Zwerling J, Cordell E, Sonnenfeld D, Willis H, La Lima CN, Baker C, Ghazzaoui R, Girson R, Sanchez C, Wright B, Alford M, Varias A, Filippou-Frye M, Shen H, Jo B, Shuer L, Frost RO, and Rodriguez CI

Subjects
Activities of Daily Living, Adult, Aged, Feasibility Studies, Female, Humans, Middle Aged, Pilot Projects, Hoarding Disorder therapy, Outcome Assessment, Health Care, Psychotherapy, Group methods
Abstract

Hoarding disorder is characterized by difficulty parting with possessions and by clutter that impairs the functionality of living spaces. Cognitive behavioral therapy conducted by a therapist (individual or in a group) for hoarding symptoms has shown promise. For those who cannot afford or access the services of a therapist, one alternative is an evidence-based, highly structured, short-term, skills-based group using CBT principles but led by non-professional facilitators (the Buried in Treasures [BIT] Workshop). BIT has achieved improvement rates similar to those of psychologist-led CBT. Regardless of modality, however, clinically relevant symptoms remain after treatment, and new approaches to augment existing treatments are needed. Based on two recent studies - one reporting that personalized care and accountability made treatments more acceptable to individuals with hoarding disorder and another reporting that greater number of home sessions were associated with better clinical outcomes, we tested the feasibility and effectiveness of adding personalized, in-home uncluttering sessions to the final weeks of BIT. Participants (n = 5) had 15 sessions of BIT and up to 20 hours of in-home uncluttering. Reductions in hoarding symptoms, clutter, and impairment of daily activities were observed. Treatment response rate was comparable to rates in other BIT studies, with continued improvement in clutter level after in-home uncluttering sessions. This small study suggests that adding in-home uncluttering sessions to BIT is feasible and effective., (Published by Elsevier Ltd.)

Published
2018
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279. Gabapentin Use in Acute Alcohol Withdrawal Management.

Author

Wilming C, Alford M, and Klaus L

Abstract

Gabapentin's anxiolytic and sedative properties along with its overall safety profile suggest that it may be a viable adjuvant to lorazepam in the management of acute alcohol withdrawal., Competing Interests: Author disclosures The authors report no actual or potential conflicts of interest with regard to this article.

Published
2018

280. Compact Stars with Sequential QCD Phase Transitions.

Author

Alford M and Sedrakian A

Abstract

Compact stars may contain quark matter in their interiors at densities exceeding several times the nuclear saturation density. We explore models of such compact stars where there are two first-order phase transitions: the first from nuclear matter to a quark-matter phase, followed at a higher density by another first-order transition to a different quark-matter phase [e.g., from the two-flavor color-superconducting (2SC) to the color-flavor-locked (CFL) phase]. We show that this can give rise to two separate branches of hybrid stars, separated from each other and from the nuclear branch by instability regions, and, therefore, to a new family of compact stars, denser than the ordinary hybrid stars. In a range of parameters, one may obtain twin hybrid stars (hybrid stars with the same masses but different radii) and even triplets where three stars, with inner cores of nuclear matter, 2SC matter, and CFL matter, respectively, all have the same mass but different radii.

Published
2017
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281. Validity of the iPhone M7 motion co-processor as a pedometer for able-bodied ambulation.

Author

Major MJ and Alford M

Subjects
Actigraphy standards, Adult, Female, Humans, Male, Reproducibility of Results, Young Adult, Actigraphy methods, Mobile Applications, Smartphone, Walking physiology
Abstract

Physical activity benefits for disease prevention are well-established. Smartphones offer a convenient platform for community-based step count estimation to monitor and encourage physical activity. Accuracy is dependent on hardware-software platforms, creating a recurring challenge for validation, but the Apple iPhone® M7 motion co-processor provides a standardised method that helps address this issue. Validity of the M7 to record step count for level-ground, able-bodied walking at three self-selected speeds, and agreement with the StepWatch TM was assessed. Steps were measured concurrently with the iPhone® (custom application to extract step count), StepWatch TM and manual count. Agreement between iPhone® and manual/StepWatch TM count was estimated through Pearson correlation and Bland-Altman analyses. Data from 20 participants suggested that iPhone® step count correlations with manual and StepWatch TM were strong for customary (1.3 ± 0.1 m/s) and fast (1.8 ± 0.2 m/s) speeds, but weak for the slow (1.0 ± 0.1 m/s) speed. Mean absolute error (manual-iPhone®) was 21%, 8% and 4% for the slow, customary and fast speeds, respectively. The M7 accurately records step count during customary and fast walking speeds, but is prone to considerable inaccuracies at slow speeds which has important implications for certain patient groups. The iPhone® may be a suitable alternative to the StepWatch TM for only faster walking speeds.

Published
2016
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282. Healthcare resource utilization after medium-term residential assessment for epilepsy and psychogenic nonepileptic seizures.

Author

Anderson J, Hill J, Alford M, Oto M, Russell A, and Razvi S

Subjects
Adult, Electroencephalography methods, Epilepsy psychology, Female, Humans, Male, Middle Aged, Psychophysiologic Disorders psychology, Retrospective Studies, Scotland, Seizures psychology, Delivery of Health Care statistics & numerical data, Epilepsy diagnosis, Health Services statistics & numerical data, Psychophysiologic Disorders diagnosis, Seizures diagnosis
Abstract

Introduction: Epilepsy and epilepsy mimics may lead to high healthcare resource utilization (HRU) including diagnostic resources. The William Quarrier Scottish Epilepsy Centre (SEC) provides medium-term residential assessment (MTRA; average length of stay: 28days) and treatment for complex presentations of epilepsy and related conditions (principally psychogenic nonepileptic seizures, PNES). We studied the effect of MTRA on HRU in a defined health board area in Scotland., Methods: A retrospective audit of individuals admitted to the SEC from a defined health board area using SEC and health board medical records. Neurological HRU assessed included emergency department visits, hospital admissions, outpatient clinic appointments, and brain imaging prior to and post-MTRA. Healthcare resource utilization was also compared with individuals referred but not admitted to the SEC because of individual circumstances and choice., Results: Seventy-three individuals (51 female, average age: 37.51; 22 men, average age: 43.72) were identified from three years of admissions (1st April 2010 to 31st March 2013). Final diagnosis was epilepsy (ES), 32; ES and psychogenic nonepileptic seizures (ES+PNES), 17; and PNES alone, 24. Twenty-two individuals were identified as a comparison group (8 men, 14 women; average age: 37.21 and 43.90, respectively). Total average contacts per patient per year (CPY) was significantly different pre- and post-MTRA (4.16 vs. 1.32; t(72)=6.11, p<.0001, d=.72). Comparison of HRU in the first year of baseline and last full year of follow-up showed a post-MTRA reduction in HRU for PNES of 92.28%, for ES of 46.81%, and for ES+PNES of 28.3%. During the course of follow-up, PNES CPY continued to drop (1.13 first year vs. 0.10 at 3years post-MTRA). For individuals with epilepsy (with or without PNES), HRU use dropped significantly in the year after admission, and these gains remained stable (total first vs. third postdischarge CPY, 1.74 vs. 1.29). The participants in the comparison group, who were not admitted, had no comparable drop across the study period and were using significantly more resources at each follow-up point than those in the admitted group (F (1, 48)=44.45, p<.01, ηp(2)=.49)., Conclusion: Medium-term residential assessment is associated with sustained reduction in HRU especially in patients with PNES. Overall HRU reduction was 68.27% following admission (d=.72). This suggests benefit from the MTRA model for people with complex presentations., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
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283. Validity and Reliability of a Glucometer Against Industry Reference Standards.

Author

Salacinski AJ, Alford M, Drevets K, Hart S, and Hunt BE

Abstract

As an appealing alternative to reference glucose analyzers, portable glucometers are recommended for self-monitoring at home, in the field, and in research settings. The purpose was to characterize the accuracy and precision, and bias of glucometers in biomedical research. Fifteen young (20-36 years; mean = 24.5), moderately to highly active men (n = 10) and women (n = 5), defined by exercising 2 to 3 times a week for the past 6 months, were given an oral glucose tolerance test (OGTT) after an overnight fast. Participants ingested 50, 75, or 150 grams of glucose over a 5-minute period. The glucometer was compared to a reference instrument. The glucometer had 39% of values within 15% of measurements made using the reference instrument ranging from 45.05 to 169.37 mg/dl. There was both a proportional (-0.45 to -0.39) and small fixed (5.06 and 0.90 mg/dl) bias. Results of the present study suggest that the glucometer provided poor validity and reliability results compared to the results provided by the reference laboratory analyzer. The portable glucometers should be used for patient management, but not for diagnosis, treatment, or research purposes., (© 2014 Diabetes Technology Society.)

Published
2014
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284. A method-comparison study regarding the validity and reliability of the Lactate Plus analyzer.

Author

Hart S, Drevets K, Alford M, Salacinski A, and Hunt BE

Abstract

Objectives: The aims of this study were to: (1) determine the validity and reliability of the Nova Biomedical Lactate Plus portable analyzer, and quantify any fixed or proportional bias; (2) determine the effect of any bias on the determination of the lactate threshold and (3) determine the effect that blood sampling methods have on validity and reliability., Design: In this method comparison study we compared blood lactate concentration measured using the Lactate Plus portable analyzer to lactate concentration measured by a reference analyzer, the YSI 2300., Setting: University campus in the USA., Participants: Fifteen active men and women performed a discontinuous graded exercise test to volitional exhaustion on a motorised treadmill. Blood samples were taken via finger prick and collected in microcapillary tubes for analysis by the reference instrument at the end of each stage. Duplicate samples for the portable analyzer were either taken directly from the finger or from the micro capillary tubes. PRIMARY OUTCOME MEASUREMENTS: Ordinary least products regressions were used to assess validity, reliability and bias in the portable analyzer. Lactate threshold was determined by visual inspection., Results: Though measurements from both instruments were correlated (r=0.91), the differences between instruments had large variability (SD=1.45 mM/l) when blood was sampled directly from finger. This variability was reduced by ∼95% when both instruments measured blood collected in the capillary tubes. As the proportional and fixed bias between instruments was small, there was no difference in estimates of the lactate threshold between instruments. Reliability for the portable instrument was strong (r=0.99, p<0.05) with no proportional bias (slope=1.02) and small fixed bias (-0.19 mM/l)., Conclusions: The Lactate Plus analyzer provides accurate and reproducible measurements of blood lactate concentration that can be used to estimate workloads corresponding to blood lactate transitions or any absolute lactate concentrations.

Published
2013
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285. Human endonuclease V as a repair enzyme for DNA deamination.

Author

Mi R, Alford-Zappala M, Kow YW, Cunningham RP, and Cao W

Subjects
DNA metabolism, Deoxyribonuclease (Pyrimidine Dimer) genetics, Escherichia coli genetics, Gene Transfer Techniques, Humans, Inosine analogs & derivatives, Inosine metabolism, Mutation, Thioredoxins metabolism, DNA Repair, DNA Repair Enzymes metabolism, Deamination, Deoxyribonuclease (Pyrimidine Dimer) metabolism
Abstract

The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reports biochemical properties of human endonuclease V with respect to repair of deaminated base lesions. Using soluble proteins fused to thioredoxin at the N-terminus, we determined repair activities of human endonuclease V on deoxyinosine (I)-, deoxyxanthosine (X)-, deoxyoxanosine (O)- and deoxyuridine (U)-containing DNA. Human endonuclease V is most active with deoxyinosine-containing DNA but with minor activity on deoxyxanthosine-containing DNA. Endonuclease activities on deoxyuridine and deoxyoxanosine were not detected. The endonuclease activity on deoxyinosine-containing DNA follows the order of single-stranded I>G/I>T/I>A/I>C/I. The preference of the catalytic activity correlates with the binding affinity of these deoxyinosine-containing DNAs. Mg(2+) and to a much less extent, Mn(2+), Ni(2+), Co(2+) can support the endonuclease activity. Introduction of human endonuclease V into Escherichia coli cells deficient in nfi, mug and ung genes caused three-fold reduction in mutation frequency. This is the first report of deaminated base repair activity for human endonuclease V. The relationship between the endonuclease activity and deaminated deoxyadenosine (deoxyinosine) repair is discussed., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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286. Information needs across the colorectal cancer care continuum: scoping the literature.

Author

van Mossel C, Leitz L, Scott S, Daudt H, Dennis D, Watson H, Alford M, Mitchell A, Payeur N, Cosby C, Levi-Milne R, and Purkis ME

Subjects
Humans, Colorectal Neoplasms, Health Services Needs and Demand, Information Services, Patient Education as Topic
Abstract

Because cancer care requires a multifaceted approach, providing useful and timely information to people with colorectal cancer may be fragmented and inconsistent. Our interest was in examining what has and has not captured the attention of researchers speaking to the information needs of people with colorectal cancer. We followed Arksey and O'Malley's framework for the methodology of scoping review. Focusing solely on colorectal cancer, we analysed 239 articles to get a picture of which information needs and sources of information, as well as the timing of providing information, were attended to. Treatment-related information received the most mentions (26%). Healthcare professionals (49%) were mentioned as the most likely source of information. Among articles focused on one stage of the care continuum, post-treatment (survivorship) received the most attention (16%). Only 27% of the articles consulted people with colorectal cancer and few attended to diet/nutrition and bowel management. This study examined the numerical representation of issues to which researchers attend, not the quality of the mentions. We ponder, however, on the relationship between the in/frequency of mentions and the actual information needs of people with colorectal cancer as well as the availability, sources and timing of information., (© 2012 Blackwell Publishing Ltd.)

Published
2012
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287. Challenges of patient-centred care: practice or rhetoric.

Author

van Mossel C, Alford M, and Watson H

Subjects
Decision Making, Humans, Models, Nursing, Neoplasms nursing, Oncology Nursing, Qualitative Research, Neoplasms therapy, Patient Participation psychology, Patient-Centered Care organization & administration, Patient-Centered Care trends, Professional-Patient Relations
Published
2011
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289. Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions.

Author

Watanabe MA, Alford M, Schneider R, Bauer A, Barthel P, Stein PK, and Schmidt G

Subjects
Adrenergic beta-Antagonists therapeutic use, Chi-Square Distribution, Databases, Factual, Electrocardiography, Ambulatory, Female, Heart Conduction System drug effects, Heart Conduction System physiopathology, Humans, Male, Mathematical Computing, Middle Aged, Myocardial Infarction drug therapy, Myocardial Infarction physiopathology, Predictive Value of Tests, Signal Processing, Computer-Assisted, Ventricular Premature Complexes physiopathology, Circadian Rhythm drug effects, Heart Rate drug effects
Abstract

Background: Demonstration of a circadian rhythm in two parameters of heart rate turbulence--turbulence onset (TO) and turbulence slope (TS)--has been difficult., Objective: The aim of this study was to devise a new method for detecting circadian rhythm in noisy data and to apply it to selected Holter recordings from two postmyocardial infarction databases: Cardiac Arrhythmia Suppression Trial (CAST, n = 684) and Innovative Stratification of Arrhythmic Risk (ISAR, n = 327)., Methods: For each patient, TS and TO were calculated for each hour with >4 ventricular premature contractions (VPCs). An autocorrelation function Corr(Deltat) = then was calculated and averaged over all patients. Positive Corr(Deltat) indicates that TS at a given hour and Deltat hours later are similar. TO was treated likewise. Simulations and mathematical analysis showed that a circadian rhythm required Corr(Deltat) to have a U-shape consisting of positive values near Deltat = 0 and 23 and negative values for intermediate Deltat. Significant deviation of Corr(Deltat) from the correlator function of pure noise was evaluated as a Chi-square value., Results: Circadian patterns were not apparent in hourly averages of TS and TO plotted against clock time, which had large error bars. However, their correlator functions produced Chi-square values of approximately 10 in CAST (both P <.0001) and approximately 3 in ISAR (both P <.0001), indicating the presence of circadian rhythmicity., Conclusion: Correlator functions may be a powerful tool for detecting the presence of circadian rhythms in noisy data, even with recordings limited to 24 hours.

Published
2007
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290. Astrophysics: quark matter in compact stars?

Author

Alford M, Blaschke D, Drago A, Klähn T, Pagliara G, and Schaffner-Bielich J

Abstract

In a theoretical interpretation of observational data from the neutron star EXO 0748-676, Ozel concludes that quark matter probably does not exist in the centre of neutron stars. However, this conclusion is based on a limited set of possible equations of state for quark matter. Here we compare Ozel's observational limits with predictions based on a more comprehensive set of proposed quark-matter equations of state from the literature, and conclude that the presence of quark matter in EXO 0748-676 is not ruled out.

Published
2007
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291. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.

Author

Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, and Masliah E

Subjects
Alzheimer Disease, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor chemistry, Animals, Aspartic Acid Endopeptidases, Blotting, Western, Brain metabolism, Brain ultrastructure, DNA, Complementary metabolism, Humans, Immunohistochemistry, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Transgenic, Middle Aged, Neurodegenerative Diseases metabolism, Neurons metabolism, Promoter Regions, Genetic, Protein Structure, Tertiary, RNA metabolism, RNA, Messenger metabolism, Time Factors, Amyloid beta-Peptides genetics, Amyloid beta-Peptides metabolism, Endopeptidases metabolism
Abstract

Amyloid-beta peptides (Abeta) are widely presumed to play a causal role in Alzheimer disease. Release of Abeta from the amyloid precursor protein (APP) requires proteolysis by the beta-site APP-cleaving enzyme (BACE1). Although increased BACE1 activity in Alzheimer disease brains and human (h) BACE1 transgenic (tg) mice results in altered APP cleavage, the contribution of these molecular alterations to neurodegeneration is unclear. We therefore used the murine Thy1 promoter to express high levels of hBACE1, with or without hAPP, in neurons of tg mice. Compared with hAPP mice, hBACE1/hAPP doubly tg mice had increased levels of APP C-terminal fragments (C89, C83) and decreased levels of full-length APP and Abeta. In contrast to non-tg controls and hAPP mice, hBACE1 mice and hBACE1/hAPP mice showed degeneration of neurons in the neocortex and hippocampus and degradation of myelin. Neurological deficits were also more severe in hBACE1 and hBACE1/hAPP mice than in hAPP mice. These results demonstrate that high levels of BACE1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo. This pathogenic pathway involves the accumulation of APP C-terminal fragments but does not depend on increased production of human Abeta. Thus, inhibiting BACE1 may block not only Abeta-dependent but also Abeta-independent pathogenic mechanisms.

Published
2005
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292. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease.

Author

Tiraboschi P, Hansen LA, Masliah E, Alford M, Thal LJ, and Corey-Bloom J

Subjects
Age of Onset, Aged, Aged, 80 and over, Alleles, Alzheimer Disease epidemiology, Alzheimer Disease metabolism, Alzheimer Disease pathology, Apolipoprotein E2, Apolipoprotein E4, Apolipoproteins E genetics, Brain enzymology, Brain pathology, California epidemiology, Choline O-Acetyltransferase analysis, Cohort Studies, Female, Follow-Up Studies, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Nerve Tissue Proteins analysis, Neurofibrillary Tangles genetics, Plaque, Amyloid genetics, Single-Blind Method, Alzheimer Disease genetics, Apolipoproteins E physiology
Abstract

Background: The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains controversial. In contrast, the epsilon2 allele has been reported to decrease the risk for AD. However, its effect on neuropathologic and neurochemical markers of disease is unclear., Objective: To investigate the relationship between APOE genotype and both pathologic severity and cholinergic dysfunction in AD., Methods: In an autopsy series of 296 patients with AD, APOE genotype was determined in blood or postmortem brain tissue. NPs and NFTs were counted in the midfrontal (MF), inferior parietal (IP), and superior temporal (ST) cortices and the hippocampus. Choline acetyltransferase (ChAT) activity was assessed in the MF, IP, and ST cortices., Results: Compared with patients with no epsilon4 alleles, epsilon4 carriers (patients with either one or two epsilon4 alleles) did not differ significantly with regard to any pathologic or neurochemical measures, except for increased ST NPs. However, when cases were stratified into three groups according to the number of epsilon4 alleles, patients with two epsilon4 alleles had significantly more NPs and NFTs in all neocortical regions than those with either one or no epsilon4 alleles. The association of the epsilon4/4 genotype with neocortical pathologic severity remained significant even after adjusting for age at onset or age at death. In contrast, there were no significant group differences with regard to neocortical ChAT activity. When pathologic and neurochemical measures were compared between patients with the epsilon2 allele and those without, a strong relationship emerged between the epsilon2 allele and decreased NPs in all neocortical regions., Conclusions: The epsilon4 allele does not predict cholinergic decline in AD. Although the presence of a single epsilon4 allele appears to have no effect, the presence of two epsilon4 alleles is an important determinant of both NP and NFT accumulation. A putative protective role for the epsilon2 allele in AD may be mediated by reduced plaque burden.

Published
2004
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293. Gapless color-flavor-locked quark matter.

Author

Alford M, Kouvaris C, and Rajagopal K

Abstract

In neutral cold quark matter that is so dense that the strange quark mass Ms is unimportant, all three quark flavors pair in a color-flavor locked (CFL) pattern, and all nine fermionic quasiparticles have a gap Delta (or 2Delta). We argue that, as the density decreases (or Ms increases), there is a quantum phase transition (at M(2s/mu approximately 2Delta) to a new "gapless CFL phase" in which only seven quasiparticles have a gap. There is still an unbroken U(1)(Q) gluon/photon, but, unlike CFL, gapless CFL is a Q conductor with gapless (charged) quasiquarks and a nonzero electron density at zero temperature, so its low energy effective theory and astrophysical properties are qualitatively new. At the transition, the dispersion relations of both gapless quasiparticles are quadratic, but for larger M2s/mu, one becomes conventionally linear while the other remains quadratic, up to tiny corrections.

Published
2004
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294. Alzheimer disease without neocortical neurofibrillary tangles: "a second look".

Author

Tiraboschi P, Sabbagh MN, Hansen LA, Salmon DP, Merdes A, Gamst A, Masliah E, Alford M, Thal LJ, and Corey-Bloom J

Subjects
Aged, Aged, 80 and over, Alzheimer Disease genetics, Alzheimer Disease metabolism, Apolipoproteins E genetics, California, Choline O-Acetyltransferase analysis, Disease Progression, Female, Genotype, Humans, Immunohistochemistry, Male, Neocortex metabolism, Neuropsychological Tests statistics & numerical data, Organ Size, Protein Isoforms genetics, Synaptophysin analysis, Alzheimer Disease pathology, Neocortex pathology, Neurofibrillary Tangles pathology, Plaque, Amyloid pathology
Abstract

Objective: To compare the clinical and pathologic features of plaque only Alzheimer disease (POAD) with plaque and tangle Alzheimer disease (PTAD)., Methods: An autopsy series of 16 patients with POAD and 32 subjects with PTAD on whom extensive antemortem neuropsychological testing was available. Plaques, tangles, and cerebral amyloid angiopathy were examined in the neocortex and hippocampus using thioflavin S staining. In addition, immunocytochemical analysis with AT8 for phosphorylated tau was performed. Midfrontal (MF) synaptic density, MF choline acetyltransferase (ChAT) activity, and apolipoprotein E genotyping were also assessed., Results: Initial neuropsychological test scores and rates of cognitive decline on the Mini-Mental State Examination and Blessed Information-Memory-Concentration were similar between the two groups. However, compared to PTAD, POAD patients tended to deteriorate more slowly on the Mattis Dementia Rating Scale. Furthermore, they were somewhat less impaired on all these measures at last examination. There was an older age at onset and death, and a trend toward a shorter disease duration, in POAD compared to PTAD patients. POAD subjects, by definition, had no neocortical neurofibrillary tangles (NFT) (Braak stages IV or less). In addition, they also had fewer hippocampal NFT, fewer neuritic plaques, and higher mean MF ChAT activity than PTAD subjects. On the other hand, the two groups did not differ significantly in brain weight or MF synaptic density. Although lacking overt tangle formation, the POAD group displayed abnormal phosphorylated tau immunoreactivity in neocortical pyramidal neurons., Conclusions: Dementing syndromes virtually indistinguishable from each other can, and do, develop in the presence or absence of neocortical NFT. Patients without neocortical NFT are, on average, older at disease onset and death, and show a trend toward a shorter disease duration with somewhat slower deterioration. Although neocortical NFT per se are not obligatory for the development of clinical dementia, more subtle neocortical cytoskeletal tau pathology may contribute to cognitive decline in these subjects.

Published
2004
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295. Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

Author

Van Uden E, Mallory M, Veinbergs I, Alford M, Rockenstein E, and Masliah E

Subjects
Animals, Dendrites metabolism, Dendrites pathology, Disease Models, Animal, Disease Progression, Hippocampus metabolism, Hippocampus pathology, Homozygote, Humans, Immunohistochemistry, LDL-Receptor Related Protein-Associated Protein genetics, Mice, Mice, Transgenic, Microtubule-Associated Proteins biosynthesis, Neocortex metabolism, Neocortex pathology, Neurodegenerative Diseases genetics, Neurodegenerative Diseases pathology, Amyloid metabolism, Amyloid beta-Protein Precursor genetics, Extracellular Space metabolism, LDL-Receptor Related Protein-Associated Protein deficiency, Neurodegenerative Diseases physiopathology
Abstract

The low-density lipoprotein receptor-related protein (LRP) is an abundant neuronal cell surface receptor that regulates amyloid beta-protein (Abeta) trafficking into the cell. Specifically, LRP binds secreted Abeta complexes and mediates its degradation. Previously, we have shown in vitro that the uptake of Abeta mediated by LRP is protective and that blocking this receptor significantly enhances neurotoxicity. To further characterize the effects of LRP and other lipoprotein receptors on Abeta deposition, an in vivo model of decreased LRP expression, receptor-associated protein (RAP)-deficient (RAP-/-) mice was crossed with human amyloid protein precursor transgenic (hAPP tg) mice, and plaque formation and neurodegeneration were analyzed. We found that, although the age of onset for plaque formation was the same in hAPP tg and hAPP tg/RAP-/- mice, the amount of amyloid deposited doubled in the hAPP tg/RAP-/- background. Moreover, these mice displayed increased neuronal damage and astrogliosis. Together, these results further support the contention that LRP and other lipoprotein receptors might be neuroprotective against Abeta toxicity and that this receptor might play an integral role in Abeta clearance.

Published
2002

296. Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease.

Author

Tiraboschi P, Hansen LA, Alford M, Merdes A, Masliah E, Thal LJ, and Corey-Bloom J

Subjects
Aged, Alzheimer Disease enzymology, Alzheimer Disease pathology, Brain Stem enzymology, Brain Stem pathology, Choline O-Acetyltransferase analysis, Cholinergic Fibers enzymology, Cholinergic Fibers pathology, Cognition Disorders diagnosis, Cognition Disorders enzymology, Cognition Disorders pathology, Cohort Studies, Diagnosis, Differential, Disease Progression, Female, Humans, Lewy Bodies pathology, Lewy Body Disease enzymology, Lewy Body Disease pathology, Male, Neocortex chemistry, Neocortex pathology, Neuropsychological Tests statistics & numerical data, Severity of Illness Index, Alzheimer Disease diagnosis, Choline O-Acetyltransferase metabolism, Lewy Body Disease diagnosis, Neocortex enzymology
Abstract

Background: Reductions in cholinergic function occur in Alzheimer disease (AD) and dementia with Lewy bodies and correlate with cognitive decline. However, whether such alterations appear in early-stage disease is unclear., Objective: To examine the timing of cholinergic deficits in AD and dementia with Lewy bodies., Methods: Autopsy series of 89 patients with AD and 50 patients with the Lewy body variant of AD (LBV). Stage of disease was stratified according to results of the last Mini-Mental State Examination (MMSE) before death as mild, moderate, severe, or very severe. We analyzed choline acetyltransferase (ChAT) activity in the midfrontal, superior temporal, and inferior parietal cortices., Results: Although compared with a normal control group ChAT activity was decreased in the AD and LBV cohorts, ChAT activity reduction for the LBV cohort was much greater. Moreover, although the decline in ChAT activity in the AD cohort compared with the normal control group was significant only for patients in later stages of the illness, the decline in the LBV cohort was significant for those who died with mild-stage disease. When less impaired patients in each cohort (MMSE, > or = 10) underwent separate analysis, the relationship of ChAT activity with the MMSE score was strong and significant for the LBV cohort alone., Conclusions: Although cholinergic deficits are seen in both AD and LBV, loss of ChAT activity is less severe and occurs later in the clinical course of AD. Conversely, in LBV, loss of ChAT activity is already prominent in the earliest stages of the illness, suggesting that cholinergic replacement therapy may be more effective in LBV than in AD, especially in mild-stage disease.

Published
2002
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297. Persistent visual loss following retrobulbar hemorrhage.

Author

Patel AD, Alford M, and Carter KD

Subjects
Aged, Aged, 80 and over, Blindness physiopathology, Drainage, Female, Humans, Retrobulbar Hemorrhage diagnostic imaging, Retrobulbar Hemorrhage surgery, Suction, Tomography, X-Ray Computed, Visual Acuity, Visual Fields, Blindness etiology, Retrobulbar Hemorrhage complications
Published
2002
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298. Effects of Cerebrolysin on amyloid-beta deposition in a transgenic model of Alzheimer's disease.

Author

Rockenstein E, Mallory M, Mante M, Alford M, Windisch M, Moessler H, and Masliah E

Subjects
Alzheimer Disease pathology, Animals, Disease Models, Animal, Mice, Mice, Transgenic, Nerve Degeneration drug therapy, Nerve Degeneration metabolism, Nerve Degeneration pathology, Alzheimer Disease drug therapy, Alzheimer Disease metabolism, Amino Acids pharmacology, Amyloid beta-Peptides metabolism, Nootropic Agents pharmacology
Abstract

We investigated the potential mechanisms through which Cerebrolysin, a neuroprotective noothropic agent, might affect Alzheimer's disease pathology. Transgenic (tg) mice expressing mutant human (h) amyloid precursor protein 751 (APP751) cDNA under the Thy-1 promoter (mThy1-hAPP751) were treated for four weeks with this compound and analyzed by confocal microscopy to asses its effects on amyloid plaque formation and neurodegeneration. In this model, amyloid plaques in the brain are found much earlier (beginning at 3 months) than in other tg models. Quantitative computer-aided analysis with anti-amyloid-beta protein (A beta) antibodies, revealed that Cerebrolysin significantly reduced the amyloid burden in the frontal cortex of 5-month-old mice. Furthermore, Cerebrolysin treatment reduced the levels of A beta(1-42). This was accompanied by amelioration of the synaptic alterations in the frontal cortex of mThy1-hAPP751 tg mice. In conclusion, the present study supports the possibility that Cerebrolysin might have neuroprotective effects by decreasing the production of A beta(1-42) and reducing amyloid deposition.

Published
2002

299. Correlation of nicotinic receptor binding with clinical and neuropathological changes in Alzheimer's disease and dementia with Lewy bodies.

Author

Sabbagh MN, Reid RT, Hansen LA, Alford M, and Thal LJ

Subjects
Aged, Aged, 80 and over, Analysis of Variance, Cerebral Cortex metabolism, Cerebral Cortex pathology, Cognition Disorders metabolism, Cognition Disorders pathology, Humans, Neurofibrillary Tangles metabolism, Neurofibrillary Tangles pathology, Alzheimer Disease metabolism, Alzheimer Disease pathology, Lewy Body Disease metabolism, Lewy Body Disease pathology, Receptors, Nicotinic metabolism
Abstract

We investigated the relationship between the loss of nicotinic acetylcholine receptors (nAChR) and the cognitive decline or neuropathological changes seen in Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB). Midfrontal (MF) cortex of 31 AD, 24 DLB and 11 non-demented controls was examined. Total plaque (TP), neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were obtained. NAChR binding was assayed using 3H-epibatidine [3H-EPI]. Last Blessed Information-Memory-Concentration scores (BIMC), Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale (DRS) scores were collected. There were no correlations between 3H-EPI binding and TP, NP, NFTs counts in either AD or DLB. Last BIMC, MMSE, DRS scores did not correlate with 3H-EPI binding in AD or DLB. Thus, decline in cognitive function does not correlate with loss of nAChR in DLB or AD at the end of life suggesting that later in these diseases, loss of nAChR binding is not a reliable marker of cognitive function in AD or DLB. Loss of nAChR activity does not appear to be related to plaques or NFTs in AD or DLB.

Published
2001
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300. The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease.

Author

Tiraboschi P, Hansen LA, Alford M, Masliah E, Thal LJ, and Corey-Bloom J

Subjects
Aged, Aged, 80 and over, Alzheimer Disease psychology, Female, Humans, Immunohistochemistry, Male, Psychiatric Status Rating Scales, Alzheimer Disease pathology, Brain pathology, Cholinergic Fibers pathology, Synapses pathology
Abstract

Objective: To determine the timing of cholinergic loss and reduction of synapses in AD., Background: Decrements in neocortical synapses and cholinergic function occur in AD and correlate with cognitive decline. However, how early in the disease process these changes appear remains unclear., Methods: An autopsy series of 89 demented patients with pathologically confirmed AD (National Institute on Aging and Consortium to Establish a Registry for Alzheimer's Disease criteria) and 18 normal control subjects (NC). The AD cases were stratified according to their last Mini-Mental State Examination (MMSE) score prior to death as mild (MMSE = 20; n = 14), moderate (MMSE = 10 to 19; n = 20), severe (MMSE = 1 to 9; n = 29), and very severe (MMSE = 0; n = 26). Midfrontal (MF) synapse density was assessed by dot-immunobinding assay for synaptophysin (Syn), and MF choline acetyltransferase (ChAT) activity was determined using standard protocols., Results: Compared with those in NC, neither Syn nor ChAT was appreciably reduced in patients with mild AD at death. Decline of ChAT was significant only in AD patients who died in the late stages of the disease and was maximal in those who had more severely deteriorated. In contrast, decline of Syn was significant and almost maximal in patients in intermediate or moderate stages. Consequently, the last MMSE score prior to death correlated more strongly with ChAT than Syn when the AD cohort included more impaired patients (r = 0.46 versus 0.40). The reverse occurred when only less impaired patients (MMSE = 10) were included in the analyses (r = 0.28 versus 0.64). There was only a modest correlation between Syn and ChAT activity., Conclusions: The results imply an asynchronous pattern of decline of synapses and cholinergic activity, with Syn loss preceding ChAT decrements. However, neither MF synapse reduction nor cholinergic dysfunction appears to be an early event in AD.

Published
2000
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