362,679 results on '"Ludwig A"'
Search Results
252. Prehabilitation of Elderly Patients With Frailty Syndrome Before Elective Surgery (PRAEP-GO)
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Ludwig-Maximilians - University of Munich, The Institute for Medical Information Processing, Biometry, and Epidemiology, Technische Universität Berlin, BARMER, and Claudia Spies, Univ.- Prof. Dr. Claudia Spies
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- 2024
253. Learning Based Dynamic Cluster Reconfiguration for UAV Mobility Management with 3D Beamforming
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Meer, Irshad A., Besser, Karl-Ludwig, Ozger, Mustafa, Schupke, Dominic, Poor, H. Vincent, and Cavdar, Cicek
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
In modern cell-less wireless networks, mobility management is undergoing a significant transformation, transitioning from single-link handover management to a more adaptable multi-connectivity cluster reconfiguration approach, including often conflicting objectives like energy-efficient power allocation and satisfying varying reliability requirements. In this work, we address the challenge of dynamic clustering and power allocation for unmanned aerial vehicle (UAV) communication in wireless interference networks. Our objective encompasses meeting varying reliability demands, minimizing power consumption, and reducing the frequency of cluster reconfiguration. To achieve these objectives, we introduce a novel approach based on reinforcement learning using a masked soft actor-critic algorithm, specifically tailored for dynamic clustering and power allocation., Comment: 6 pages, 4 figures
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- 2024
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254. Scalable Mechanism Design for Multi-Agent Path Finding
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Friedrich, Paul, Zhang, Yulun, Curry, Michael, Dierks, Ludwig, McAleer, Stephen, Li, Jiaoyang, Sandholm, Tuomas, and Seuken, Sven
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Computer Science - Artificial Intelligence ,Computer Science - Computer Science and Game Theory ,Computer Science - Multiagent Systems - Abstract
Multi-Agent Path Finding (MAPF) involves determining paths for multiple agents to travel simultaneously and collision-free through a shared area toward given goal locations. This problem is computationally complex, especially when dealing with large numbers of agents, as is common in realistic applications like autonomous vehicle coordination. Finding an optimal solution is often computationally infeasible, making the use of approximate, suboptimal algorithms essential. Adding to the complexity, agents might act in a self-interested and strategic way, possibly misrepresenting their goals to the MAPF algorithm if it benefits them. Although the field of mechanism design offers tools to align incentives, using these tools without careful consideration can fail when only having access to approximately optimal outcomes. In this work, we introduce the problem of scalable mechanism design for MAPF and propose three strategyproof mechanisms, two of which even use approximate MAPF algorithms. We test our mechanisms on realistic MAPF domains with problem sizes ranging from dozens to hundreds of agents. We find that they improve welfare beyond a simple baseline., Comment: 12 pages, 5 figures. IJCAI'24 camera-ready version
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- 2024
255. Exploring one giga electronvolt cosmic gamma rays with a Cherenkov plenoscope capable of recording atmospheric light fields, Part 1: Optics
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Mueller, Sebastian Achim, Daglas, Spyridon, Engels, Axel Arbet, Ahnen, Max Ludwig, Neise, Dominik, Egger, Adrian, Chatzi, Eleni, Biland, Adrian, and Hofmann, Werner
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Detecting cosmic gamma rays at high rates is the key to time-resolve the acceleration of particles within some of the most powerful events in the universe. Time-resolving the emission of gamma rays from merging celestial bodies, apparently random bursts of gamma rays, recurring novas in binary systems, flaring jets from active galactic nuclei, clocking pulsars, and many more became a critical contribution to astronomy. For good timing on account of high rates, we would ideally collect the naturally more abundant, low energetic gamma rays in the domain of one giga electronvolt in large areas. Satellites detect low energetic gamma rays but only in small collecting areas. Cherenkov telescopes have large collecting areas but can only detect the rare, high energetic gamma rays. To detect gamma rays with lower energies, Cherenkov-telescopes need to increase in precision and size. But when we push the concept of the -- far/tele -- seeing Cherenkov telescope accordingly, the telescope's physical limits show more clearly. The narrower depth-of-field of larger mirrors, the aberrations of mirrors, and the deformations of mirrors and mechanics all blur the telescope's image. To overcome these limits, we propose to record the -- full/plenum -- Cherenkov-light field of an atmospheric shower, i.e. recording the directions and impacts of each individual Cherenkov photon simultaneously, with a novel class of instrument. This novel Cherenkov plenoscope can turn a narrow depth-of-field into the perception of depth, can compensate aberrations, and can tolerate deformations. We design a Cherenkov plenoscope to explore timing by detecting low energetic gamma rays in large areas., Comment: An interdisciplinary effort investigated by physicists and civil engineers. For simulations, see https://github.com/cherenkov-plenoscope. 28 pages, 25 figures, 50 references, 100% motivation. Log:(2024 February 09) Add journal reference, update email and affiliations
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- 2024
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256. Entropy-calibrated stellar modeling: Testing and improving the use of prescriptions for entropy of adiabatic convection
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Manchon, L., Deal, M., Goupil, M. -J., Serenelli, A., Lebreton, Y., Klevas, J., Kučinskas, A., Ludwig, H. -G., Montalbán, J., and Gizon, L.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The modeling of convection is a long standing problem in stellar physics. Up-to-now, all ad hoc models rely on a free parameter alpha (among others) which has no real physical justification and is therefore poorly constrained. However, a link exists between this free parameter and the entropy of the stellar adiabat. Prescriptions, derived from 3D stellar atmospheric models, are available that provide entropy as a function of stellar atmospheric parameters (effective temperature, surface gravity, chemical composition). This can provide constraints on alpha through the development of entropy-calibrated models. Several questions arise as these models are increasingly used. Which prescription should be used? How do uncertainties impact entropy-calibrated models? We aim to study the three existing prescriptions and determine which one should be used, and how. We implemented the entropy-calibration method into the stellar evolution code Cesam2k20 and performed comparisons with the Sun and the alpha Cen system. In addition, we used data from the CIFIST grid of 3D atmosphere models to evaluate the accuracy of the prescriptions. Of the three entropy prescriptions available, we determine which one best reproduces the entropies of the 3D models. We also demonstrate that the entropy obtained from this prescription should be corrected for the evolving chemical composition and for an entropy offset different between various EoS tables, following a precise procedure, otherwise classical parameters obtained from the models will be strongly biased. Finally, we also provide table with entropy of the adiabat of the CIFIST grid, as well as fits of these entropies. We performed a precise examination of entropy-calibrated modelling, and gave recommendations on which adiabatic entropy prescription to use, how to correct it and to implement the method into a stellar evolution code., Comment: 18 pages, 11 figures. Submitted to Astronomy and Astrophysics, recommended for publication with minor revisions
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- 2024
257. Switching the sign of the Casimir force between two PEMC spheres
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Schoger, Tanja and Ingold, Gert-Ludwig
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Quantum Physics - Abstract
For non-reciprocal objects in vacuum, the Casimir interaction can become repulsive. Here, we present a comprehensive study for idealized non-reciprocal materials known as perfect electromagnetic conductors (PEMC). The system consists of two spheres made of different PEMC materials, including the plane-sphere geometry as a particular case. The sign of the Casimir force does not only depend on the distance between the spheres and their geometric parameters but can be controlled by adjusting the temperature. A repulsive Casimir interaction at small distances allows for stable equilibrium configurations of the spheres. A sum rule previously derived for the plane-plane geometry at zero temperature is violated in general, if at least one plane is replaced by a sphere.
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- 2024
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258. Efficacy of Venetoclax in Combination With Rituximab in Waldenström's Macroglobulinemia (VIWA-1)
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Ludwig-Maximilians - University of Munich, Zentrum für Klinische Studien Ulm, AbbVie, Pfizer, University Hospital Schleswig-Holstein, Campus Kiel, and Christian Buske, Prof. Dr.
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- 2024
259. Bartholomew's trend test -- approximated by a multiple contrast test
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Hothorn, Ludwig A.
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Statistics - Methodology - Abstract
Bartholomew's trend test belongs to the broad class of isotonic regression models, specifically with a single qualitative factor, e.g. dose levels. Using the approximation of the ANOVA F-test by the maximum contrast test against grand mean and pool-adjacent-violator estimates under order restriction, an easier to use approximation is proposed., Comment: 1 figure, 5 tables
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- 2024
260. pyAKI -- An Open Source Solution to Automated KDIGO classification
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Porschen, Christian, Ernsting, Jan, Brauckmann, Paul, Weiss, Raphael, Würdemann, Till, Booke, Hendrik, Amini, Wida, Maidowski, Ludwig, Risse, Benjamin, Hahn, Tim, and von Groote, Thilo
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Computer Science - Machine Learning ,Computer Science - Software Engineering - Abstract
Acute Kidney Injury (AKI) is a frequent complication in critically ill patients, affecting up to 50% of patients in the intensive care units. The lack of standardized and open-source tools for applying the Kidney Disease Improving Global Outcomes (KDIGO) criteria to time series data has a negative impact on workload and study quality. This project introduces pyAKI, an open-source pipeline addressing this gap by providing a comprehensive solution for consistent KDIGO criteria implementation. The pyAKI pipeline was developed and validated using a subset of the Medical Information Mart for Intensive Care (MIMIC)-IV database, a commonly used database in critical care research. We defined a standardized data model in order to ensure reproducibility. Validation against expert annotations demonstrated pyAKI's robust performance in implementing KDIGO criteria. Comparative analysis revealed its ability to surpass the quality of human labels. This work introduces pyAKI as an open-source solution for implementing the KDIGO criteria for AKI diagnosis using time series data with high accuracy and performance.
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- 2024
261. Addressing researcher degrees of freedom through minP adjustment
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Mandl, Maximilian M, Becker-Pennrich, Andrea S, Hinske, Ludwig C, Hoffmann, Sabine, and Boulesteix, Anne-Laure
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Statistics - Methodology - Abstract
When different researchers study the same research question using the same dataset they may obtain different and potentially even conflicting results. This is because there is often substantial flexibility in researchers' analytical choices, an issue also referred to as ''researcher degrees of freedom''. Combined with selective reporting of the smallest p-value or largest effect, researcher degrees of freedom may lead to an increased rate of false positive and overoptimistic results. In this paper, we address this issue by formalizing the multiplicity of analysis strategies as a multiple testing problem. As the test statistics of different analysis strategies are usually highly dependent, a naive approach such as the Bonferroni correction is inappropriate because it leads to an unacceptable loss of power. Instead, we propose using the ''minP'' adjustment method, which takes potential test dependencies into account and approximates the underlying null distribution of the minimal p-value through a permutation-based procedure. This procedure is known to achieve more power than simpler approaches while ensuring a weak control of the family-wise error rate. We illustrate our approach for addressing researcher degrees of freedom by applying it to a study on the impact of perioperative paO2 on post-operative complications after neurosurgery. A total of 48 analysis strategies are considered and adjusted using the minP procedure. This approach allows to selectively report the result of the analysis strategy yielding the most convincing evidence, while controlling the type 1 error -- and thus the risk of publishing false positive results that may not be replicable.
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- 2024
262. Realizing limit cycles in dissipative bosonic systems
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Skulte, Jim, Kongkhambut, Phatthamon, Keßler, Hans, Hemmerich, Andreas, Mathey, Ludwig, and Cosme, Jayson G.
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Condensed Matter - Quantum Gases ,Quantum Physics - Abstract
We propose a general mechanism for generating limit cycle (LC) oscillations by coupling a linear bosonic mode to a dissipative nonlinear bosonic mode. By analyzing the stability matrix, we show that LCs arise due to a supercritical Hopf bifurcation. We find that the existence of LCs is independent of the sign of the effective nonlinear interaction. The LC phase can be classified as a continuous time crystal (CTC), if it emerges in a many-body system. The bosonic model can be realised in three-level systems interacting with a quantised light mode as realised in atom-cavity systems. Using such a platform, we experimentally observe LCs for the first time in an atom-cavity system with attractive optical pump lattice, thereby confirming our theoretical predictions.
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- 2024
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263. Pulse Checks Using Femoral Artery B-Mode Ultrasound With Compressibility Assessment
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Ludwig Boltzmann Institute Digital Health and Patient Safety, Emergency Medical Service of Vienna, and Philipp Metelka, Resident
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- 2024
264. Influence of an Anti-osteoporotic Drug on Healing After Surgical Repair of Chronic Rotator Cuff Lesions of the Shoulder (ZORRO)
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Ludwig Boltzmann Institute for Traumatology - The research center in cooperation with AUVA, CCSRM Clinical Center for Studies in Regenerative Medicine in cooperation with the Ludwig Boltzmann Institute for Traumatology, and Jakob Schanda, Principal Investigator
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- 2024
265. 150 Years of Women at CED (College of Environmental Design)
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Fullerton, Sarah and Ludwig, Lisa
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150w ,UCB ,Women in Environmental Design and Architecture - Published
- 2024
266. Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
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Magaret, Craig, Li, Li, deCamp, Allan, Rolland, Morgane, Juraska, Michal, Williamson, Brian, Ludwig, James, Molitor, Cindy, Benkeser, David, Luedtke, Alex, Simpkins, Brian, Heng, Fei, Sun, Yanqing, Carpp, Lindsay, Bai, Hongjun, Dearlove, Bethany, Giorgi, Elena, Jongeneelen, Mandy, Brandenburg, Boerries, McCallum, Matthew, Bowen, John, Veesler, David, Sadoff, Jerald, Gray, Glenda, Roels, Sanne, Vandebosch, An, Stieh, Daniel, Le Gars, Mathieu, Vingerhoets, Johan, Grinsztejn, Beatriz, Goepfert, Paul, de Sousa, Leonardo, Silva, Mayara, Casapia, Martin, Losso, Marcelo, Gaur, Aditya, Bekker, Linda-Gail, Garrett, Nigel, Truyers, Carla, Van Dromme, Ilse, Swann, Edith, Marovich, Mary, Follmann, Dean, Neuzil, Kathleen, Corey, Lawrence, Greninger, Alexander, Roychoudhury, Pavitra, Hyrien, Ollivier, Gilbert, Peter, and Little, Susan
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Humans ,Ad26COVS1 ,COVID-19 ,SARS-CoV-2 ,Vaccine Efficacy ,Amino Acids ,Antibodies ,Viral ,Antibodies ,Neutralizing - Abstract
In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe-critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 vaccine and 1,067 placebo recipients who acquired COVID-19. In this set of prespecified analyses, we show that in Latin America, VE was significantly lower against Lambda vs. Reference and against Lambda vs. non-Lambda [family-wise error rate (FWER) p
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- 2024
267. Precise in situ radius measurement of individual optically trapped microspheres using negative optical torque exerted by focused vortex beams
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Diniz, Kainã, Schoger, Tanja, Moura, Guilherme T., Fonseca, Arthur L., Ether Jr, Diney S., Dutra, Rafael S., Ingold, Gert-Ludwig, Viana, Nathan B., and Neto, Paulo A. Maia
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Physics - Optics ,Physics - Applied Physics - Abstract
We demonstrate a new method for determining the radius of micron-sized particles trapped by a vortex laser beam. The technique is based on measuring the rotation experienced by the center of mass of a microsphere that is laterally displaced by a Stokes drag force to an off-axis equilibrium position. The rotation results from an optical torque pointing along the direction opposite to the vortex beam angular momentum. We fit the rotation angle data for different Laguerre-Gaussian modes taking the radius as a fitting parameter in the Mie-Debye theory of optical tweezers. We also discuss how micron-sized beads can be used as probes for optical aberrations introduced by the experimental setup., Comment: 11 pages, 5 figures
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- 2023
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268. Equilibrium Parametric Amplification in Raman-Cavity Hybrids
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Collado, H. P. Ojeda, Michael, Marios H., Skulte, Jim, Rubio, Angel, and Mathey, Ludwig
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Parametric resonances and amplification have led to extraordinary photoinduced phenomena in pump-probe experiments. While these phenomena manifest themselves in out-of-equilibrium settings, here, we present the striking result of parametric amplification in equilibrium. In particular, we demonstrate that quantum and thermal fluctuations of a Raman-active mode amplifies light inside a cavity, at equilibrium, when the Raman mode frequency is twice the cavity mode frequency. This noise-driven amplification leads to the creation of an unusual parametric Raman polariton, intertwining the Raman mode with cavity squeezing fluctuations, with smoking gun signatures in Raman spectroscopy. In the resonant regime, we show the emergence of not only quantum light amplification but also localization and static shift of the Raman mode. Apart from the fundamental interest of equilibrium parametric amplification our study suggests a resonant mechanism for controlling Raman modes and thus matter properties by cavity fluctuations. We conclude by outlining how to compute the Raman-cavity coupling, and suggest possible experimental realization, Comment: as accepted in PRL
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- 2023
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269. Non-linear photoconductivity of strongly driven graphene
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Broers, Lukas and Mathey, Ludwig
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Other Condensed Matter - Abstract
We present the non-linear DC photoconductivity of graphene under strong infra-red (IR) radiation. The photoconductivity is obtained as the response to a strong DC electric field, with field strengths outside of the linear-response regime, while the IR radiation is described by a strong AC electric field. The conductivity displays two distinct regimes in which either the DC or the AC field dominates. We explore these regimes and associate them with the dynamics of driven Landau-Zener quenches in the case of a large DC field. In the limit of large AC field, we describe the conductivity in a Floquet picture and compare the results to the closely related Tien-Gordon effect. We present analytical calculations for the non-linear differential photoconductivity, for both regimes based on the corresponding mechanisms. As part of this discussion of the non-equilibrium state of graphene, we present analytical estimates of the conductivity of undriven graphene as a function of temperature and DC bias field strength that show very good agreement with our simulations.
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- 2023
270. Accelerated adiabatic passage of a single electron spin qubit in quantum dots
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Liu, Xiao-Fei, Matsumoto, Yuta, Fujita, Takafumi, Ludwig, Arne, Wieck, Andreas D., and Oiwa, Akira
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Adiabatic processes can keep the quantum system in its instantaneous eigenstate, which is robust to noises and dissipation. However, it is limited by sufficiently slow evolution. Here, we experimentally demonstrate the transitionless quantum driving (TLQD) of the shortcuts to adiabaticity in gate-defined semiconductor quantum dots (QDs) to greatly accelerate the conventional adiabatic passage for the first time. For a given efficiency of quantum state transfer, the acceleration can be more than twofold. The dynamic properties also prove that the TLQD can guarantee fast and high-fidelity quantum state transfer. In order to compensate for the diabatic errors caused by dephasing noises, the modified TLQD is proposed and demonstrated in experiment by enlarging the width of the counter-diabatic drivings. The benchmarking shows that the state transfer fidelity of 97.8% can be achieved. This work will greatly promote researches and applications about quantum simulations and adiabatic quantum computation based on the gate-defined QDs., Comment: 6 pages, 3 figures
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- 2023
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271. Modelling the Lymphatic Metastatic Progression Pathways of OPSCC from Multi-Institutional Datasets
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Ludwig, Roman, Schubert, Adrian, Barbatei, Dorothea, Bauwens, Lauence, Hoffmann, Jean-Marc, Werlen, Sandrine, Elicin, Olgun, Dettmer, Matthias, Zrounba, Philippe, Pouymayou, Bertrand, Balermpas, Panagiotis, Grégoire, Vincent, Giger, Roland, and Unkelbach, Jan
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Physics - Medical Physics - Abstract
The elective clinical target volume (CTV-N) in oropharyngeal squamous cell carcinoma (OPSCC) is currently based mostly on the prevalence of lymph node metastases in different lymph node levels (LNLs) for a given primary tumor location. We present a probabilistic model for ipsilateral lymphatic spread that can quantify the microscopic nodal involvement risk based on an individual patient's T-category and clinical involvement of LNLs at diagnosis. We extend a previously published hidden Markov model (HMM), which models the LNLs (I, II, III, IV, V, and VII) as hidden binary random variables (RVs). Each represents a patient's true state of lymphatic involvement. Clinical involvement at diagnosis represents the observed binary RVs linked to the true state via sensitivity and specificity. The primary tumor and the hidden RVs are connected in a graph. Each edge represents the conditional probability of metastatic spread per abstract time-step, given disease at the edge's starting node. To learn these probabilities, we draw Markov chain Monte Carlo samples from the likelihood of a dataset (686 OPSCC patients) from three institutions. We compute the model evidence using thermodynamic integration for different graphs to determine which describes the data best. The graph maximizing the model evidence connects the tumor to each LNL and the LNLs I through V in order. It predicts the risk of occult disease in level IV is below 5% if level III is clinically negative, and that the risk of occult disease in level V is below 5% except for advanced T-category (T3 and T4) patients with clinical involvement of levels II, III, and IV. The provided statistical model of nodal involvement in OPSCC patients trained on multi-institutional data may guide the design of clinical trials on volume-deescalated treatment of OPSCC and contribute to more personal guidelines on elective nodal treatment., Comment: 17 pages, 12 figures, 7 tables, submitted to Physics in Medicine and Biology
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- 2023
272. Photonic fusion of entangled resource states from a quantum emitter
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Meng, Yijian, Faurby, Carlos F. D., Chan, Ming Lai, Sund, Patrik I., Liu, Zhe, Wang, Ying, Bart, Nikolai, Wieck, Andreas D., Ludwig, Arne, Midolo, Leonardo, Sørensen, Anders S., Paesani, Stefano, and Lodahl, Peter
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Quantum Physics - Abstract
Fusion-based photonic quantum computing architectures rely on two primitives: i) near-deterministic generation and control of constant-size entangled states and ii) probabilistic entangling measurements (photonic fusion gates) between entangled states. Here, we demonstrate these key functionalities by fusing resource states deterministically generated using a solid-state spin-photon interface. Repetitive operation of the source leads to sequential entanglement generation, whereby curiously entanglement is created between the quantum states of the same spin at two different instances in time. Such temporal multiplexing of photonic entanglement provides a resource-efficient route to scaling many-body entangled systems with photons.
- Published
- 2023
273. Benchmarking Distribution Shift in Tabular Data with TableShift
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Gardner, Josh, Popovic, Zoran, and Schmidt, Ludwig
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Computer Science - Machine Learning - Abstract
Robustness to distribution shift has become a growing concern for text and image models as they transition from research subjects to deployment in the real world. However, high-quality benchmarks for distribution shift in tabular machine learning tasks are still lacking despite the widespread real-world use of tabular data and differences in the models used for tabular data in comparison to text and images. As a consequence, the robustness of tabular models to distribution shift is poorly understood. To address this issue, we introduce TableShift, a distribution shift benchmark for tabular data. TableShift contains 15 binary classification tasks in total, each with an associated shift, and includes a diverse set of data sources, prediction targets, and distribution shifts. The benchmark covers domains including finance, education, public policy, healthcare, and civic participation, and is accessible using only a few lines of Python code via the TableShift API. We conduct a large-scale study comparing several state-of-the-art tabular data models alongside robust learning and domain generalization methods on the benchmark tasks. Our study demonstrates (1) a linear trend between in-distribution (ID) and out-of-distribution (OOD) accuracy; (2) domain robustness methods can reduce shift gaps but at the cost of reduced ID accuracy; (3) a strong relationship between shift gap (difference between ID and OOD performance) and shifts in the label distribution. The benchmark data, Python package, model implementations, and more information about TableShift are available at https://github.com/mlfoundations/tableshift and https://tableshift.org ., Comment: NeurIPS 2023 Dataset and Benchmarks Track accepted version
- Published
- 2023
274. High-throughput study of the phase constitution of the thin film system Mg-Mn-Al-O in relation to Li recovery from slags
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Lourens, Florian, Suhr, Ellen, Schnickmann, Alena, Schirmer, Thomas, and Ludwig, Alfred
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Condensed Matter - Materials Science - Abstract
The increasing importance of recycling makes the recovery of valuable elements from slags interesting, e.g., by the concept of engineered artificial minerals (EnAMs). In this concept, it is aimed for the formation of EnAMs, meaning phase(s) with a high content of the to-be-recovered element(s) from slags of pyrometallurgical recycling processes. For this, understanding the phase constitution of the slag systems is of high importance. The system Mg-Mn-Al-O is a metal oxide slag subsystem from Li-ion battery recycling, that is critical for the formation of spinel phases, which are competing phases to the possible Li-containing EnAM phase LiAlO2. Here, the phase constitution was investigated using a thin film materials library that covers the composition space (Mg14-69Mn11-38Al14-74)Ox. By means of high-throughput energy-dispersive X-ray spectroscopy and X-ray diffraction, the formation of the spinel solid solution phase was confirmed for a wide composition space. Increasing preferential orientation of the spinel solid solution along (400) with increasing Mg content was identified. X-ray photoelectron spectroscopy was used to measure the near-surface composition of selected areas of the materials library, and detailed peak fitting of the Mn 2p3/2 region revealed the Mn oxidation state to be a mixture of Mn2+ and Mn3+. For one measurement area of the materials library containing equal atomic amounts of Mg, Mn and Al, transmission electron microscopy showed that the approximately 420 nm-thick film consists of columnar spinel grains with Mg, Mn and Al being evenly distributed. Based on these results, we suggest that the shown high likelihood of spinel formation in slags might be influenced by controlling the Mn oxidation state to enable the formation of desirable EnAM phases.
- Published
- 2023
275. Reinforcement Learning Based Dynamic Power Control for UAV Mobility Management
- Author
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Meer, Irshad A., Besser, Karl-Ludwig, Ozger, Mustafa, Poor, H. Vincent, and Cavdar, Cicek
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Modern communication systems need to fulfill multiple and often conflicting objectives at the same time. In particular, new applications require high reliability while operating at low transmit powers. Moreover, reliability constraints may vary over time depending on the current state of the system. One solution to address this problem is to use joint transmissions from a number of base stations (BSs) to meet the reliability requirements. However, this approach is inefficient when considering the overall total transmit power. In this work, we propose a reinforcement learning-based power allocation scheme for an unmanned aerial vehicle (UAV) communication system with varying communication reliability requirements. In particular, the proposed scheme aims to minimize the total transmit power of all BSs while achieving an outage probability that is less than a tolerated threshold. This threshold varies over time, e.g., when the UAV enters a critical zone with high-reliability requirements. Our results show that the proposed learning scheme uses dynamic power allocation to meet varying reliability requirements, thus effectively conserving energy., Comment: 5 pages, 3 figures
- Published
- 2023
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276. Computing the Frequency-Dependent NMR Relaxation of $^1$H Nuclei in Liquid Water
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Paschek, Dietmar, Busch, Johanna, Mock, Eduard, Ludwig, Ralf, and Strate, Anne
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Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics - Abstract
It is the purpose of this paper to present a computational framework for reliably determining the frequency-dependent intermolecular and intramolecular NMR dipole-dipole relaxation rate of spin $1/2$ nuclei from MD simulations. The approach avoids alterations caused by well-known finite-size effects of the translational diffusion. Moreover, a procedure is derived to control and correct for effects caused by fixed distance-sampling cutoffs and periodic boundary conditions. By construction, this approach is capable of accurately predicting the correct low-frequency scaling behavior of the intermolecular NMR dipole-dipole relaxation rate and thus allows the reliable calculation of the frequency-dependent relaxation rate over many orders of magnitude. Our approach is based on the utilisation of the theory of Hwang and Freed for the intermolecular dipole-dipole correlation function and its corresponding spectral density [J. Chem. Phys. 63, 4017 (1975)] and its combination with data from molecular dynamics (MD) simulations. The deviations from the Hwang and Freed theory caused by periodic boundary conditions and sampling distance cutoffs are quantified by means of random walker Monte Carlo simulations. An expression based on the Hwang and Freed theoryis also suggested for correcting those effects. As a proof of principle, our approach is demonstrated by computing the frequency-dependent inter- and intramolecular dipolar NMR relaxation rate of the $^1$H nuclei in liquid water at $273\,\mbox{K}$ and $298\,\mbox{K}$ based on simulations of the TIP4P/2005 model. Our calculations are suggesting that the intermolecular contribution to the $^1$H NMR relaxation rate of the TIP4P/2005 model in the extreme narrowing limit has previously been substantially underestimated., Comment: 15 pages, 8 figures, removed typos, added an additional Figure 4, corrected mistake in Figure 8 (previously Figure 7)
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- 2023
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277. MoSi Superconducting Nanowire Single-Photon Detectors on GaAs for On-Chip Integration
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Erbe, M., Berrazouane, R., Geyer, S., Stasi, L., van der Brugge, F., Gras, G., Schmidt, M., Wieck, A. D., Ludwig, A., Bussières, F., and Warburton, R. J.
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Physics - Applied Physics - Abstract
We report on MoSi-based superconducting nanowire single-photon detectors on a gallium arsenide substrate. MoSi deposited on a passivated GaAs surface has the same critical temperature as MoSi deposited on silicon. The critical temperature decreases slightly on depositing MoSi directly on the native oxide of GaAs. Hence, MoSi works well as a thin-film superconductor on GaAs. We propose that the amorphous structure of MoSi ensures compatibility with the GaAs matrix. Superconducting nanowire single-photon detectors (SNSPDs) are fabricated with MoSi on GaAs using a meander-wire design. The SNSPD metrics are very similar to those of devices fabricated with the same procedure on a silicon substrate. We observe a plateau in the response-versus-bias curve signalling a saturated internal quantum efficiency. The plateau remains even at an elevated temperature, 2.2 K, at a wavelength of 980 nm. We achieve a timing jitter of 50 ps and a recovery time of 29 ns. These results point to the promise of integrating MoSi SNSPDs with GaAs photonic circuits.
- Published
- 2023
278. The Association between Boredom and Creativity in Educational Contexts: A Scoping Review on Research Approaches and Empirical Findings
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Anke Zeißig, Julia Kansok-Dusche, Saskia M. Fischer, Julia Moeller, and Ludwig Bilz
- Abstract
Assumptions around the association between boredom and creativity are contentious. Although studies suggest positive effects of boredom, it is also considered a negative predictor of creativity. Researchers also assume that creativity reduces boredom, but boredom can also occur during creative tasks. In this review, we identify and systematise the empirical evidence available to date on the association between creativity and boredom in educational contexts. The string-guided electronic search yielded 2849 publications. Nineteen publications based on 27 empirical studies met the inclusion criteria. Two reviewers extracted definitions, theories, methods, operationalisations, measurement instruments, and outcomes from the studies using a coding scheme. We identified a range of different theoretical and methodological approaches. The largest cache of empirical evidence was obtained from experimental and quasi-experimental studies (five positive associations, four negative, two contradictory, and three insignificant results). Correlation studies identified three negative, one contradictory, and seven insignificant correlations between boredom and creativity. In addition, two studies with exploratory, statistically not relevant results contributed to the body of research. The results from the identified and evaluated studies argue both for and against the sensitivity of creative processes in relation to boredom--but a clear causal, positive or negative effect of boredom on creativity is not currently supported by the empirical evidence available. Previous research has also not yet demonstrated an apparent effect of creative states or traits on academic boredom. Future research should aim to explore under what circumstances different relationships between boredom and creativity can be observed and reliably replicated.
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- 2024
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279. Topology-Driven Ordering of Flocking Matter
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Amélie Chardac, Ludwig A. Hoffmann, Yoann Poupart, Luca Giomi, and Denis Bartolo
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Physics ,QC1-999 - Abstract
When interacting motile units self-organize into flocks, they realize one of the most robust ordered states found in nature. However, after 25 years of intense research, the very mechanism controlling the ordering dynamics of both living and artificial flocks has remained unsettled. Here, combining active-colloid experiments, numerical simulations, and analytical work, we explain how flocking liquids heal their spontaneous flows initially plagued by collections of topological defects to achieve long-ranged polar order even in two dimensions. We demonstrate that the self-similar ordering of flocking matter is ruled by a living network of domain walls linking all ±1 vortices and guiding their annihilation dynamics. Crucially, this singular orientational structure echoes the formation of extended density patterns in the shape of interconnected bow ties. We establish that this double structure emerges from the interplay between self-advection and density gradients dressing each -1 topological charge with four orientation walls. We then explain how active Magnus forces link all topological charges with extended domain walls, while elastic interactions drive their attraction along the resulting filamentous network of polarization singularities. Taken together, our experimental, numerical, and analytical results illuminate the suppression of all flow singularities and the emergence of pristine unidirectional order in flocking matter.
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- 2021
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280. Effects of Ultrasonic Use on Hearing Loss in Dental Hygienists: A matched pairs design study
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Suedbeck, Jessica, Ludwig, Emily A., Blando, James, and Michalak, Nathan
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Dental hygienists -- Medical examination ,Hearing loss -- Diagnosis -- Risk factors -- Demographic aspects ,Ultrasonic equipment -- Usage -- Safety and security measures - Abstract
Purpose Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise. Methods A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a series of auditory tests including otoacoustic emissions test, pure-tone audiometry, and tympanometry on the experimental and control groups. Results In the right ear, there were notable differences from 1000 Hz-10,000 Hz and in the left ear from 6000 Hz-10,000 Hz, with higher hearing thresholds in the experimental group of dental hygienists. While 56% of the univariate tests conducted on how many days were worked per week showed statistical significance, the regression line slope indicated those that worked more days had better hearing statuses. The variables for years in practice for dental hygienists, how many of those years were full-time employment, and how many years the dental hygienist had used an ultrasonic scaling device, also had many significant univariate tests for the experimental group only. These variables were more likely to serve as proxies representing true noise exposure. The paired t-test between the groups demonstrated statistically significant differences between the experimental and control group at 9000 Hz in both ears. Conclusion While results from this study demonstrated various qualitative differences in hearing status of the control group (non-dental hygienists) and experimental group (dental hygienists), age was found to be the most critical variable. Furthermore, this data demonstrated differences in hearing status based on various frequencies between dental hygienists and age-matched controls that should be further explored with a larger population. Keywords dental hygienists, ultrasonic instrumentation, hearing loss, occupational noise exposure NDHRA priority area, Professional development: Occupational health (determination and assessment of risks). Submitted for publication: 5/16/2024; accepted after revision: 7/1/2024, INTRODUCTION Research dating back to the 1990's has indicated dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. (1) Since that time, the rate [...]
- Published
- 2024
281. Author Correction: From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions
- Author
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Mori, Matteo, Zhang, Zhongge, Banaei-Esfahani, Amir, Lalanne, Jean-Benoît, Okano, Hiroyuki, Collins, Ben C, Schmidt, Alexander, Schubert, Olga T, Lee, Deok-Sun, Li, Gene-Wei, Aebersold, Ruedi, Hwa, Terence, and Ludwig, Christina
- Published
- 2024
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282. Can Mankind Understand the Spirit of the Liturgy Anymore?
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Müller, Gerhard Ludwig
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- 2024
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283. The Hadwiger Theorem on Convex Functions, I
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Colesanti, Andrea, Ludwig, Monika, and Mussnig, Fabian
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- 2024
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284. A new method for satellite-based remote sensing analysis of plant-specific biomass yield patterns for precision farming applications
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Hagn, Ludwig, Schuster, Johannes, Mittermayer, Martin, and Hülsbergen, Kurt-Jürgen
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- 2024
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285. Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
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Alerie Guzman De La Fuente, Simona Lange, Maria Elena Silva, Ginez A. Gonzalez, Herbert Tempfer, Peter van Wijngaarden, Chao Zhao, Ludovica Di Canio, Andrea Trost, Lara Bieler, Pia Zaunmair, Peter Rotheneichner, Anna O’Sullivan, Sebastien Couillard-Despres, Oihana Errea, Maarja A. Mäe, Johanna Andrae, Liqun He, Annika Keller, Luis F. Bátiz, Christer Betsholtz, Ludwig Aigner, Robin J.M. Franklin, and Francisco J. Rivera
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neurovascular niche ,pericytes ,remyelination ,oligodendrocyte progenitor cell ,Lama2 ,Biology (General) ,QH301-705.5 - Abstract
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.
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- 2017
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286. Discussion on Modeling Capability for Macrosegregation
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Wu Menghuai, Kharicha Abdellah, and Ludwig Andreas
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macrosegregation ,solidification ,crystal growth ,heat and mass transfer ,porosity ,diffusion kinetics ,Technology ,Chemical technology ,TP1-1185 ,Chemicals: Manufacture, use, etc. ,TP200-248 - Abstract
Macrosegregation originates from the solute partitioning at the liquid-solid interface and the relative motion between liquid and solid phases during solidification of metal alloys. A suitable macrosegregation model should incorporate solidification thermodynamics, crystal growth kinetics, multiphase computational fluid dynamics, and even thermal-structural mechanics. No current model includes all those phenomena, hence leading to assumptions having to be made. This paper discusses some modeling assumptions regarding the treatment of (1) diffusion kinetics of crystal growth, (2) crystal dendritic morphology and (3) solidification shrinkage. Theoretical analyses based on test calculations were made. We find that some previous models, which over-simplified some of the aspects mentioned above for the purpose of computational efficiency, can only be applied to study macrosegregation qualitatively. They lead to significant error estimations of macrosegregation. When the quantitative accuracy for macrosegregation is of primary importance, the multiphase-based models with an appropriate treatment of these aspects, despite the sophisticated computational requirements, are recommended.
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- 2017
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287. Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis
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Joanna Adamczak, Markus Aswendt, Christina Kreutzer, Peter Rotheneichner, Adrien Riou, Marion Selt, Andreas Beyrau, Ulla Uhlenküken, Michael Diedenhofen, Melanie Nelles, Ludwig Aigner, Sebastien Couillard-Despres, and Mathias Hoehn
- Subjects
Stroke ,Neurogenesis ,Age dependence of neurogenesis after stroke ,Bioluminescence imaging ,Magnetic resonance imaging ,Doublecortin ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Stroke is a leading cause of death and disability worldwide with no treatment for the chronic phase available. Interestingly, an endogenous repair program comprising inflammation and neurogenesis is known to modulate stroke outcome. Several studies have shown that neurogenesis decreases with age but the therapeutic importance of endogenous neurogenesis for recovery from cerebral diseases has been indicated as its ablation leads to stroke aggravation and worsened outcome. A detailed characterization of the neurogenic response after stroke related to ageing would help to develop novel and targeted therapies. In an innovative approach, we used the DCX-Luc mouse, a transgenic model expressing luciferase in doublecortin-positive neuroblasts, to monitor the neurogenic response following middle cerebral artery occlusion over three weeks in three age groups (2, 6, 12 months) by optical imaging while the stroke lesion was monitored by quantitative MRI. The individual longitudinal and noninvasive time profiles provided exclusive insight into age-dependent decrease in basal neurogenesis and neurogenic upregulation in response to stroke which are not accessible by conventional BrdU-based measures of cell proliferation. For cortico-striatal strokes the maximal upregulation occurred at 4 days post stroke followed by a continuous decrease to basal levels by three weeks post stroke. Older animals effectively compensated for reduced basal neurogenesis by an enhanced sensitivity to the cerebral lesion, resulting in upregulated neurogenesis levels approaching those measured in young mice. In middle aged and older mice, but not in the youngest ones, additional upregulation of neurogenesis was observed in the contralateral healthy hemisphere. This further substantiates the increased propensity of older brains to respond to lesion situation. Our results clearly support the therapeutic relevance of endogenous neurogenesis for stroke recovery and particularly in older brains.
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- 2017
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288. Getting it Right: Improving Spatial Consistency in Text-to-Image Models
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Chatterjee, Agneet, Stan, Gabriela Ben Melech, Aflalo, Estelle, Paul, Sayak, Ghosh, Dhruba, Gokhale, Tejas, Schmidt, Ludwig, Hajishirzi, Hannaneh, Lal, Vasudev, Baral, Chitta, Yang, Yezhou, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Leonardis, Aleš, editor, Ricci, Elisa, editor, Roth, Stefan, editor, Russakovsky, Olga, editor, Sattler, Torsten, editor, and Varol, Gül, editor
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- 2025
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289. Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury
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Pasquale Romanelli, Lara Bieler, Cornelia Scharler, Karin Pachler, Christina Kreutzer, Pia Zaunmair, Dominika Jakubecova, Heike Mrowetz, Bruno Benedetti, Francisco J. Rivera, Ludwig Aigner, Eva Rohde, Mario Gimona, Dirk Strunk, and Sebastien Couillard-Despres
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exosome ,inflammation ,mesenchymal stromal cells ,scarring ,spinal cord injury ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Spinal cord injury is characterized by initial neural tissue disruption that triggers secondary damage and extensive non-resolving inflammation, which aggravates loss of function and hinders recovery. The early onset of inflammation following traumatic spinal cord injury underscores the importance of acute intervention after the initial trauma. Injections of mesenchymal stromal cells (MSCs) can reduce inflammation following spinal cord injury. We asked if extracellular vesicles (EVs) can substitute the anti-inflammatory and anti-scarring activities of their parental MSCs in a rat model of contusion spinal cord injury. We report that MSC-EVs were as potent as the parental intact cells in reducing the level of neuroinflammation for up to 2 weeks post-injury. Acute application of EVs after spinal cord injury was shown to robustly decrease the expression of pro-inflammatory cytokines in the spinal cord parenchyma in the very early phase of secondary damage. Moreover, the anti-scarring impact of MSC-EVs was even more efficient than the parental cells. We therefore conclude that anti-inflammatory and anti-scarring activities of MSC application can be mediated by their secreted EVs. In light of their substantial safety and druggability advantages, EVs may have a high potential in early therapeutic treatment following traumatic spinal cord injury.
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- 2019
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290. Dimethylsulfoxide Inhibits Oligodendrocyte Fate Choice of Adult Neural Stem and Progenitor Cells
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Anna O’Sullivan, Simona Lange, Peter Rotheneichner, Lara Bieler, Ludwig Aigner, Francisco J. Rivera, and Sebastien Couillard-Despres
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oligodendrogenesis ,neural stem cells ,myelination ,DMSO ,Id2 ,Olig2 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Several clinical trials address demyelinating diseases via transplantation of mesenchymal stromal cells (MSCs). Published reports detail that administration of MSCs in patients may provide a beneficial immunomodulation, and that factors secreted by MSCs are potent inducers of oligodendrogenesis. Dimethylsulfoxide (DMSO) is widely used in life science and medicine as solvent, vehicle or cryoprotectant for cells used in transplantation. Importantly, most transplantation protocols do not include the removal of DMSO before injecting the cell suspension into patients. This indifferent application of DMSO is coming under increasing scrutiny following reports investigating its potential toxic side-effects. While the impact of DMSO on the central nervous system (CNS) has been partially studied, its effect on oligodendrocytes and oligodendrogenesis has not been addressed yet. Consequently, we evaluated the influence of DMSO on oligodendrogenesis, and on the pro-oligodendrogenic effect of MSCs’ secreted factors, using adult rat neural stem and progenitor cells (NSPCs). Here, we demonstrate that a concentration of 1% DMSO robustly suppressed oligodendrogenesis and drove the fate of differentiating NSPCs toward astrogenesis. Furthermore, the pro-oligodendrogenic effect of MSC-conditioned medium (MSCCM) was also nearly completely abolished by the presence of 1% DMSO. In this condition, inhibition of the Erk1/2 signal transduction pathway and high levels of Id2 expression, a specific inhibitor of oligodendrogenic differentiation, were detected. Furthermore, inflammatory demyelinating diseases may even potentiate the impact of DMSO on oligodendrogenesis. Our results demonstrate the imperative of considering the strong anti-oligodendrogenic activity of DMSO when designing future clinical trial protocols.
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- 2019
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291. Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
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Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, and Michael Hothorn
- Subjects
inositol pyrophosphates ,phosphate homeostasis ,phosphate starvation ,plant nutrition ,kinase ,phosphatase ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis. Here we report that deletion of two diphosphoinositol pentakisphosphate kinases VIH1/2 impairs plant growth and leads to constitutive Pi starvation responses. Deletion of phosphate starvation response transcription factors partially rescues vih1 vih2 mutant phenotypes, placing diphosphoinositol pentakisphosphate kinases in plant Pi signal transduction cascades. VIH1/2 are bifunctional enzymes able to generate and break-down PP-InsPs. Mutations in the kinase active site lead to increased Pi levels and constitutive Pi starvation responses. ATP levels change significantly in different Pi growth conditions. ATP-Mg2+ concentrations shift the relative kinase and phosphatase activities of diphosphoinositol pentakisphosphate kinases in vitro. Pi inhibits the phosphatase activity of the enzyme. Thus, VIH1 and VIH2 relay changes in cellular ATP and Pi concentrations to changes in PP-InsP levels, allowing plants to maintain sufficient Pi levels.
- Published
- 2019
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292. The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons
- Author
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Lara Bieler, Michael Vogl, Michael Kirchinger, Corinna Urmann, Herbert Riepl, Christine Bandtlow, Lars Klimaschewski, Ludwig Aigner, and Sebastien Couillard-Despres
- Subjects
flavonoids ,dorsal root ganglions ,DRG neurons ,axonal outgrowth ,semaphorin ,ephrin ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Restoration of neuronal connectivity after lesion of the central nervous system, such as spinal cord injury, is one of the biggest challenges in modern medicine. In particular, the accumulation of axon growth inhibitory factors at the site of injury constitutes a major obstacle to structural and thus functional repair. We previously investigated a group of prenylflavonoids derived from hops for their capacity to promote neuroregeneration. We identified a molecule called ENDF1 that was very potent to enhance regrowth and branching of neurites from dorsal root ganglion neurons in culture on growth promoting substrates. In the present study, we investigated ENDF1’s capacity to promote regeneration of rat dorsal root ganglion neurons in vitro in the presence of three main components of the extracellular matrix acting as axon growth inhibitors: Semaphorin 3A, Ephrin A4 and mixed chondroitin sulfate proteoglycans. We report that ENDF1 application significantly promoted the percentages of sensory neurons able to regrow their neurites regardless of the presence of those inhibitors, and this to an extent similar to the one obtained after NGF treatment. Moreover, ENDF1 strongly enhanced the total neurite length and the complexity of neurites extending from neurons challenged with axon growth inhibitors. Although the impact of NGF and ENDF1 on the regeneration of neurons was similar, the activity of ENDF1 was not mediated by signaling through the TrkA receptor, indicating that each molecule act through different signaling pathways. In addition, ENDF1 did not decrease the phosphorylation of cofilin, a downstream effector of the regeneration-associated RhoA/ROCK signaling pathway. Hence, ENDF1 is a potent pro-neuroregenerative factors that could help in identifying new efficient targets for regenerative therapies of the nervous system.
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- 2019
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293. Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells
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Maria Elena Silva, Simona Lange, Bryan Hinrichsen, Amber R. Philp, Carolina R. Reyes, Diego Halabi, Josselyne B. Mansilla, Peter Rotheneichner, Alerie Guzman de la Fuente, Sebastien Couillard-Despres, Luis F. Bátiz, Robin J. M. Franklin, Ludwig Aigner, and Francisco J. Rivera
- Subjects
pericytes ,neural stem cells ,oligodendrogenesis ,Lama2 ,remyelination ,vascular niche ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Upon demyelination, oligodendrocyte progenitor cells (OPCs) are activated and they proliferate, migrate and differentiate into myelin-producing oligodendrocytes. Besides OPCs, neural stem cells (NSCs) may respond to demyelination and generate oligodendrocytes. We have recently shown that CNS-resident pericytes (PCs) respond to demyelination, proliferate and secrete Laminin alpha2 (Lama2) that, in turn, enhances OPC differentiation. Here, we aimed to evaluate whether PCs influence the fate choice of NSCs in vitro, towards the production of new myelin-producing cells. Indeed, upon exposure to conditioned medium derived from PCs (PC-CM), the majority of NSCs gave rise to GalC- and myelin basic protein (MBP)-expressing oligodendrocytes at the expense of the generation of GFAP-positive astrocytes. Consistent with these findings, PC-CM induces an increase in the expression of the oligodendrocyte fate determinant Olig2, while the expression level of the astrocyte determinant ID2 is decreased. Finally, pre-incubation of PC-CM with an anti-Lama2 antibody prevented the generation of oligodendrocytes. Our findings indicate that PCs-derived Lama2 instructs NSCs to an oligodendrocyte fate choice favoring the generation of myelin-producing cells at the expense of astrocytes in vitro. Further studies aiming to reveal the role of PCs during remyelination may pave the way for the development of new therapies for the treatment of MS.
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- 2019
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294. Indonesia-Germany MathCityMap Training: Shifting Mobile Math Trails Teacher Training to a Hybrid Environment
- Author
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Cahyono, Adi Nur, Masrukan, Mulyono, Ludwig, Matthias, Jablonski, Simone, and Oehler, Deng-Xin Ken
- Abstract
The purpose of this study is to explore how MathCityMap training for teachers can be designed and implemented in a hybrid setting. Design research has been carried out involving teachers from 34 provinces in Indonesia. A four-day model training program for indoor and outdoor activities in a hybrid setting has been designed. The core concept of designing modeling tasks and math trails, as well as the introduction to MathCityMap, were delivered in a hybrid mode between Indonesia and Germany. The activity continued with the development of MathCityMap Trails in city parks. Post-training activities were conducted in their respective places of origin, in schools, and in city parks. Participants have successfully designed trails in both their schools and the city parks where they live supported using Learning Management System. The findings of the MathCityMap team's review indicate that most of the trails fulfilled the requirements. The trainee teachers then disseminate their knowledge and experience to their colleagues. They also used MathCityMap Trails for classroom learning as well as other activities such as MathCityMap competitions and public educational activities. The hybrid environment helps to accelerate the attainment of training objectives while also broadening the program's reach and network.
- Published
- 2023
295. Cognitive Effects of Montelukast: A Pharmaco-EEG Study
- Author
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Fabian Schwimmbeck, Wolfgang Staffen, Christopher Höhn, Fabio Rossini, Nora Renz, Markus Lobendanz, Peter Reichenpfader, Bernhard Iglseder, Ludwig Aigner, Eugen Trinka, and Yvonne Höller
- Subjects
montelukast ,EEG ,cognitive tests ,anti-inflammatory drug ,leukotriene receptor antagonist ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Montelukast is a well-established antiasthmatic drug with little side effects. It is a leukotriene receptor antagonist and recent research suggests cognitive benefits from its anti-inflammatory actions on the central nervous system. However, changes in brain activity were not directly shown so far in humans. This study aims to document changes in brain activity that are associated with cognitive improvement during treatment with Montelukast. We recorded EEG and conducted neuropsychological tests in 12 asthma-patients aged 38–73 years before and after 8 weeks of treatment with Montelukast. We found no significant changes on neuropsychological scales for memory, attention, and mood. In the EEG, we found decreased entropy at follow up during rest (p < 0.005). During episodic memory acquisition we found decreased entropy (p < 0.01) and acceleration of the background rhythm (p < 0.05). During visual attention performance, we detected an increase in gamma power (p < 0.005) and slowing of the background rhythm (p < 0.05). The study is limited by its small sample size, young age and absence of baseline cognitive impairment of the participants. Unspecific changes in brain activity were not accompanied by cognitive improvement. Future studies should examine elderly patients with cognitive impairment in a double-blind study with longer-term treatment by Montelukast.
- Published
- 2021
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296. The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
- Author
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Johanna Michael, Julia Zirknitzer, Michael Stefan Unger, Rodolphe Poupardin, Tanja Rieß, Nadine Paiement, Horst Zerbe, Birgit Hutter-Paier, Herbert Reitsamer, and Ludwig Aigner
- Subjects
leukotriene receptor antagonist ,cysteinyl leukotrienes ,montelukast ,5xFAD ,cognition ,Alzheimer’s disease ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Alzheimer’s disease (AD) is the most common form of dementia. In particular, neuroinflammation, mediated by microglia cells but also through CD8+ T-cells, actively contributes to disease pathology. Leukotrienes are involved in neuroinflammation and in the pathological hallmarks of AD. In consequence, leukotriene signaling—more specifically, the leukotriene receptors—has been recognized as a potential drug target to ameliorate AD pathology. Here, we analyzed the effects of the leukotriene receptor antagonist montelukast (MTK) on hippocampal gene expression in 5xFAD mice, a commonly used transgenic AD mouse model. We identified glial activation and neuroinflammation as the main pathways modulated by MTK. The treatment increased the number of Tmem119+ microglia and downregulated genes related to AD-associated microglia and to lipid droplet-accumulating microglia, suggesting that the MTK treatment targets and modulates microglia phenotypes in the disease model compared to the vehicle. MTK treatment further reduced infiltration of CD8+T-cells into the brain parenchyma. Finally, MTK treatment resulted in improved cognitive functions. In summary, we provide a proof of concept for MTK to be a potential drug candidate for AD and provide novel modes of action via modulation of microglia and CD8+ T-cells. Of note, 5xFAD females showed a more severe pathology, and in consequence, MTK treatment had a more pronounced effect in the females compared to the males. The effects on neuroinflammation, i.e., microglia and CD8+ T-cells, as well as the effects on cognitive outcome, were dose-dependent, therefore arguing for the use of higher doses of MTK in AD clinical trials compared to the approved asthma dose.
- Published
- 2021
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297. Bildung gemeinsam gestalten: Empfehlungen für Projekte in Kooperation zwischen Wissenschaft, Politik und Praxis
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Holzer, Julia, Grützmacher, Luisa, Ludwig, Sina, Bacher, Johann, Dumont, Hanna, Kampa, Nele, Krainer, Konrad, Lüftenegger, Marko, Maaz, Kai, Pant, Hans Anand, Prenzel, Manfred, Spiel, Christiane, and Schober, Barbara
- Published
- 2024
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298. Integrating European contexts and needs into WHO guiding principles on online mental health content for young people: five recommendations
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Ludwig-Walz, Helena, Bujard, Martin, Fegert, Jonas, and Fegert, Jörg M.
- Published
- 2024
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299. Efficacy and outcomes of rescue screws in unstable pelvic ring injuries – A retrospective matched cohort study
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Klingebiel, Felix Karl-Ludwig, Kalbas, Yannik, Klee, Octavia, Long, Anhua, Teuben, Michel, Teuber, Henrik, Halvachizadeh, Sascha, Berk, Till, Neuhaus, Valentin, Pape, Hans-Christoph, and Pfeifer, Roman
- Published
- 2024
- Full Text
- View/download PDF
300. History matters: evolutionary and demographic reconstruction of the Southwest Atlantic loggerheads (Testudinata: Cheloniidae)
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Ludwig, Sandra, Amorim, Laís, Xavier, Alberty, Guimarães, Paula Rodrigues, and Vargas, Sarah Maria
- Published
- 2024
- Full Text
- View/download PDF
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