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Controlled manipulation of particles from very large volumes of fluid at high throughput is critical for many biomedical, environmental and industrial applications. One promising approach is to use microfluidic technologies that rely on fluid inertia or elasticity to drive lateral migration of particles to stable equilibrium positions in a microchannel. Here, we report on a hydrodynamic approach that enables deterministic focusing of beads, mammalian cells and anisotropic hydrogel particles in a microchannel at extremely high flow rates. We show that on addition of micromolar concentrations of hyaluronic acid, the resulting fluid viscoelasticity can be used to control the focal position of particles at Reynolds numbers up to Re≈10,000 with corresponding flow rates and particle velocities up to 50 ml min[superscript −1] and 130 m s[superscript −1]. This study explores a previously unattained regime of inertio-elastic fluid flow and demonstrates bioparticle focusing at flow rates that are the highest yet achieved., National Institute for Biomedical Imaging and Bioengineering (U.S.) (P41 BioMicroElectroMechanical Systems Resource Center), National Institute for Biomedical Imaging and Bioengineering (U.S.) (P41 EB002503), National Science Foundation (U.S.). Graduate Research Fellowship, United States. Army Research Office (Institute for Collaborative Biotechnologies Grant W911NF-09-0001)

Theories of gravitation without Lorentz invariance are candidates of low-energy descriptions of quantum gravity. In this review we will describe the phenomenological consequences of the candidates associated to the existence of a preferred time direction, Comment: 38 pages, 3 figures; v2 references added

It has been shown that the primordial perturbations sourced by inflation are driven to classicality by unitary evolution alone. However, their coupling with the environment such as photons and subsequent decoherence renders the cosmological correlations quantum, losing primordial information in the process. We argue that the quantumness of the resulting cosmological correlations is given by quantum discord, which captures non-classical behavior beyond quantum entanglement. By considering the environment as a quantum channel in which primordial information contained in the perturbations is transmitted to us, we can then ask how much of this information is inaccessible. We show that this amount of information is given by the discord of the joint primordial perturbations-environment system. To illustrate these points, we model the joint system as a mixed bi-modal Gaussian state, and show that quantum discord is dependent on the basis which decoherence occurs., Comment: 9 pages. 2 figures

The Planck mission has conclusively detected lensing of the Cosmic Microwave Background (CMB) radiation from foreground sources to an overall significance of greater than $25\sigma$. The high precision of this measurement motivates the development of a more complete formulation of the calculation of this effect. While most effects on the CMB anisotropies are widely studied through direct solutions of the Boltzmann equation, the non-linear effect of CMB lensing is formulated through the solutions of the geodesic equation. In this paper, we present a new formalism to the calculation of the lensing effect by \emph{directly solving the Boltzmann equation}, as we did in the calculation of the CMB anisotropies at recombination. In particular, we developed a diagrammatic approach to efficiently keep track of all the interaction terms and calculate all possible non-trivial correlations to arbitrary high orders. Using this formalism, we explicitly articulate the approximations required to recover the usual remapping approach used in current studies of the weak lensing. In addition, we point out additional unexplored corrections that are manifest in our formalism to which experiments may be sensitive. As an example, we calculate the correction to the CMB temperature power spectrum for the \emph{lens-lens} coupling effects which are neglected in standard calculations. We find that the correction is $\lesssim 0.1\%$ of the CMB temperature power spectrum for $\ell$ up to 3000 and thus is comparable to the cosmic variance., Comment: 25 pages, 3 figures, 4 tables, CMB, lensing

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014., 127, Cataloged from PDF version of thesis., Includes bibliographical references (pages 100-106)., Many biological and industrial fluids are filled with micro-scale particles that can serve as "state markers" for real-world issues, such as human health and public infrastructure. In order to extract this valuable information from such fluids, the controlled manipulation of particles is often necessary. Microfluidic technologies based on viscosity-dominant flows have achieved this essential step in small-volume (

We show that the instabilities of higher derivative gravity models with quadratic curvature invariant $\alpha R^2+\beta R_{\mu\nu}R^{\mu\nu}$ can be removed by judicious addition of constraints at the quadratic level of metric fluctuations around Minkowski/de Sitter background. With a suitable parameter choice, we find that the instabilities of helicity-0, 1, 2 modes can be removed while reducing the dimensionality of the original phase space. To retain the renormalization properties of higher derivative gravity, Lorentz symmetry in the constrained theory is explicitly broken., Comment: 14 pages, no figure

We construct a perturbative framework for understanding the collision of solitons (more precisely, solitary waves) in relativistic scalar field theories. Our perturbative framework is based on the suppression of the space-time interaction area proportional to $1/(\gamma v)$, where $v$ is the relative velocity of an incoming solitary wave and $\gamma = 1/\sqrt{1-v^2} \gg 1$. We calculate the leading order results for collisions of (1+1) dimensional kinks in periodic potentials, and provide explicit, closed form expressions for the phase shift and the velocity change after the collisions. We find excellent agreement between our results and detailed numerical simulations. Crucially, our perturbation series is controlled by a kinematic parameter, and hence not restricted to small deviations around integrable cases such as the Sine-Gordon model., Comment: v3: 43 pages, 10 figures, references added, matches version accepted for publication in PRD

We derive a closed-form expression for the phase shift experienced by 1+1 dimensional kinks colliding at ultra-relativistic velocities (gamma v >> 1), valid for arbitrary periodic potentials. Our closed-form expression is the leading order result of a more general scattering theory of solitary waves described in a companion paper [Amin, Lim and Yang, arXiv:1308.0606]. This theory relies on a small kinematic parameter 1/(gamma v) << 1 rather than a small parameter in the Lagrangian. Our analytic results can be directly extracted from the Lagrangian without solving the equation of motion. Based on our closed-form expression, we prove that kink-kink and kink-antikink collisions have identical phase shifts at leading order., Comment: 4 pages, 4 figures, updated link to the companion paper and fixed some typos

Two of the most commonly used tools to constrain the primordial non-Gaussianity are the bispectrum and the Minkowski functionals of CMB temperature anisotropies. These two measures of non-Gaussianity in principle provide distinct (though correlated) information, but in the past constraints from them have only been loosely compared, and not statistically combined. In this work we evaluate, for the first time, the covariance matrix between the local non-Gaussianity coefficient fnl estimated through the bispectrum and Minkowski functionals. We find that the estimators are positively correlated, with corerlation coefficient r ~ 0.3. Using the WMAP7 data to combine the two measures and accounting for the point-source systematics, we find the combined constraint fnl=37+/-28, which has a ~20% smaller error than either of the individual constraints., Comment: 5 pages, 1 figure, 1 table; v3 updated with improved MF analysis, matches PRD published version

Inertial microfluidics has demonstrated the potential to provide a rich range of capabilities to manipulate biological fluids and particles to address various challenges in biomedical science and clinical medicine. Various microchannel geometries have been used to study the inertial focusing behavior of particles suspended in simple buffer solutions or in highly diluted blood. One aspect of inertial focusing that has not been studied is how particles suspended in whole or minimally diluted blood respond to inertial forces in microchannels. The utility of imaging techniques (i.e., high-speed bright-field imaging and long exposure fluorescence (streak) imaging) primarily used to observe particle focusing in microchannels is limited in complex fluids such as whole blood due to interference from the large numbers of red blood cells (RBCs). In this study, we used particle trajectory analysis (PTA) to observe the inertial focusing behavior of polystyrene beads, white blood cells, and PC-3 prostate cancer cells in physiological saline and blood. Identification of in-focus (fluorescently labeled) particles was achieved at mean particle velocities of up to 1.85 m s[superscript −1]. Quantitative measurements of in-focus particles were used to construct intensity maps of particle frequency in the channel cross-section and scatter plots of particle centroid coordinates vs. particle diameter. PC-3 cells spiked into whole blood (HCT = 45%) demonstrated a novel focusing mode not observed in physiological saline or diluted blood. PTA can be used as an experimental frame of reference for understanding the physical basis of inertial lift forces in whole blood and discover inertial focusing modes that can be used to enable particle separation in whole blood.

We prove that the linear instability in a non-degenerate higher derivative theory, the Ostrogradski instability, can only be removed by the addition of constraints if the original theory's phase space is reduced., Comment: 17 pages, no figures, version published in JCAP

We study cosmological perturbations by solving the governing Boltzmann and Einstein Field equations up to second order, and calculate the corresponding CMB bispectrum during recombination. We include all the second-order Liouville and collision terms, truncating the multipole hierarchy at $l=10$, consistently including all $m\neq 0$ terms when calculating the bispectrum in the flat-sky limit. At this stage, we focus on contributions at recombination and we neglect 2nd-order vector and tensor terms, lensing effects, and late time non-linear ISW. We find that the signal-to-noise for the bispectrum is 0.69 for $l_{max}=2000$, yielding an overall signal $F_{\rm NL} = 3.19$ (normalised relative to the local model). We find that the effective $f_{NL}$'s of the equilateral and local type are 5.11 and 0.88 respectively. This recombination signal will have to be taken into account in a quantitative analysis of the Planck data., Comment: 5 pages, 4 figures, CMB, second order perturbations

In this paper, we investigate the utility of Minkowski Functionals as a probe of cold/hot disk-like structures in the CMB. In order to construct an accurate estimator, we resolve a long-standing issue with the use of Minkowski Functionals as probes of the CMB sky -- namely that of systematic differences ("residuals") when numerical and analytical MF are compared. We show that such residuals are in fact by-products of binning, and not caused by pixelation or masking as originally thought. We then derive a map-independent estimator that encodes the effects of binning, applicable to beyond our present work. Using this residual-free estimator, we show that small disk-like effects (as claimed by Vielva et al.) can be detected only when a large sample of such maps are averaged over. In other words, our estimator is noise-dominated for small disk sizes at WMAP resolution. To confirm our suspicion, we apply our estimator to the WMAP7 data to obtain a null result., Comment: 15 pages, 13 figures

We investigate the effect of modifed gravity with screening mechanisms, such as the chameleon or symmetron models, upon the structure of main sequence stars. We find that unscreened stars can be significantly more luminous and ephemeral than their screened doppelgangers. By embedding these stars into dwarf galaxies, which can be unscreened for values of the parameters not yet ruled out observationally, we show that the cumulative effect of their increased luminosity can enhance the total galactic luminosity. We estimate this enhancement and find that it can be considerable given model parameters that are still under experimental scrutiny. By looking for systematic offsets between screened dwarf galaxies in clusters and unscreened galaxies in voids, these effects could form the basis of an independent observational test that can potentially lower the current experimental bounds on the model independent parameters of these theories by and order of magnitude or more., Comment: 16 pages, six figures

We provide analytic solutions for the power spectrum and bispectrum of curvature fluctuations produced by a step feature in the inflaton potential, valid in the limit that the step is short and sharp. In this limit, the bispectrum is strongly scale dependent and its effective non-linearity attains a large oscillatory amplitude. The perturbations to the curvature power spectrum, on the other hand, remain a small component on top of the usual spectrum of fluctuations generated by slow roll. We utilize our analytic solutions to assess the observability of the predicted non-Gaussian signatures and show that, if present, only very sharp steps on scales larger than ~ 2 Gpc are likely to be able to be detected by Planck. Such features are not only consistent with WMAP7 data, but can also improve its likelihood by 2 Delta ln L ~ 12 for two extra parameters, the step location and height. If this improvement were due to a slow roll violating step as considered here, a bispectrum or corresponding polarization power spectrum detection would provide definitive checks as to its primordial origin., Comment: Typos fixed, supersedes journal version

Recent studies have shown that the number counts of convergence peaks N(kappa) in weak lensing (WL) maps, expected from large forthcoming surveys, can be a useful probe of cosmology. We follow up on this finding, and use a suite of WL convergence maps, obtained from ray-tracing N-body simulations, to study (i) the physical origin of WL peaks with different heights, and (ii) whether the peaks contain information beyond the convergence power spectrum P_ell. In agreement with earlier work, we find that high peaks (with amplitudes >~ 3.5 sigma, where sigma is the r.m.s. of the convergence kappa) are typically dominated by a single massive halo. In contrast, medium-height peaks (~0.5-1.5 sigma) cannot be attributed to a single collapsed dark matter halo, and are instead created by the projection of multiple (typically, 4-8) halos along the line of sight, and by random galaxy shape noise. Nevertheless, these peaks dominate the sensitivity to the cosmological parameters w, sigma_8, and Omega_m. We find that the peak height distribution and its dependence on cosmology differ significantly from predictions in a Gaussian random field. We directly compute the marginalized errors on w, sigma_8, and Omega_m from the N(kappa) + P_ell combination, including redshift tomography with source galaxies at z_s=1 and z_s=2. We find that the N(kappa) + P_ell combination has approximately twice the cosmological sensitivity compared to P_ell alone. These results demonstrate that N(kappa) contains non-Gaussian information complementary to the power spectrum., Comment: 24 pages, 12 figures, 14 tables. Accepted for publication in PRD (version before proofs)

In this paper, we show that Minkowski Functionals (MFs) of weak gravitational lensing (WL) convergence maps contain significant non-Gaussian, cosmology-dependent information. To do this, we use a large suite of cosmological ray-tracing N-body simulations to create mock WL convergence maps, and study the cosmological information content of MFs derived from these maps. Our suite consists of 80 independent 512^3 N-body runs, covering seven different cosmologies, varying three cosmological parameters Omega_m, w, and sigma_8 one at a time, around a fiducial LambdaCDM model. In each cosmology, we use ray-tracing to create a thousand pseudo-independent 12 deg^2 convergence maps, and use these in a Monte Carlo procedure to estimate the joint confidence contours on the above three parameters. We include redshift tomography at three different source redshifts z_s=1, 1.5, 2, explore five different smoothing scales theta_G=1, 2, 3, 5, 10 arcmin, and explicitly compare and combine the MFs with the WL power spectrum. We find that the MFs capture a substantial amount of information from non-Gaussian features of convergence maps, i.e. beyond the power spectrum. The MFs are particularly well suited to break degeneracies and to constrain the dark energy equation of state parameter w (by a factor of ~ three better than from the power spectrum alone). The non-Gaussian information derives partly from the one-point function of the convergence (through V_0, the "area" MF), and partly through non-linear spatial information (through combining different smoothing scales for V_0, and through V_1 and V_2, the boundary length and genus MFs, respectively). In contrast to the power spectrum, the best constraints from the MFs are obtained only when multiple smoothing scales are combined., Comment: 19 pages, 9 figures, 5 tables

We investigate flux vacua on a variety of one-parameter Calabi-Yau compactifications, and find many examples that are connected through continuous monodromy transformations. For these, we undertake a detailed analysis of the tunneling dynamics and find that tunneling trajectories typically graze the conifold point---particular 3-cycles are forced to contract during such vacuum transitions. Physically, these transitions arise from the competing effects of minimizing the energy for brane nucleation (facilitating a change in flux), versus the energy cost associated with dynamical changes in the periods of certain Calabi-Yau 3-cycles. We find that tunneling only occurs when warping due to back-reaction from the flux through the shrinking cycle is properly taken into account., Comment: 1+62 pages, 17 figures

It has recently been shown in high resolution numerical simulations that relativistic collisions of bubbles in the context of a multi-vacua potential may lead to the creation of bubbles in a new vacuum. In this paper, we show that scalar fields with only potential interactions behave like free fields during high-speed collisions; the kick received by them in a collision can be deduced simply by a linear superposition of the bubble wall profiles. This process is equivalent to the scattering of solitons in 1+1 dimensions. We deduce an expression for the field excursion (shortly after a collision), which is related simply to the field difference between the parent and bubble vacua, i.e. contrary to expectations, the excursion cannot be made arbitrarily large by raising the collision energy. There is however a minimum energy threshold for this excursion to be realized. We verify these predictions using a number of 3+1 and 1+1 numerical simulations. A rich phenomenology follows from these collision induced excursions - they provide a new mechanism for scanning the landscape, they might end/begin inflation, and they might constitute our very own big bang, leaving behind a potentially observable anisotropy., Comment: 15pgs, 14 figures, v2, thanks for the feedbacks

We introduce a novel class of field theories where energy always flows along timelike geodesics, mimicking in that respect dust, yet which possess non-zero pressure. This theory comprises two scalar fields, one of which is a Lagrange multiplier enforcing a constraint between the other's field value and derivative. We show that this system possesses no wave-like modes but retains a single dynamical degree of freedom. Thus, the sound speed is always identically zero on all backgrounds. In particular, cosmological perturbations reproduce the standard behaviour for hydrodynamics with vanishing sound speed. Using all these properties we propose a model unifying Dark Matter and Dark Energy in a single degree of freedom. In a certain limit this model exactly reproduces the evolution history of Lambda-CDM, while deviations away from the standard expansion history produce a potentially measurable difference in the evolution of structure., Comment: 13 pages, 3 figures. Added references, corrected language.

We consider the 3-pt function (i.e. the bispectrum or non-Gaussianity) for stochastic backgrounds of gravitational waves. We estimate the amplitude of this signal for the primordial inflationary background, gravitational waves generated during preheating, and for gravitational waves produced by self-ordering scalar fields following a global phase transition. To assess detectability, we describe how to extract the 3-pt signal from an idealized interferometric experiment and compute the signal to noise ratio as a function of integration time. The 3-pt signal for the stochastic gravitational wave background generated by inflation is unsurprisingly tiny. For gravitational radiation generated by purely causal, classical mechanisms we find that, no matter how non-linear the process is, the 3-pt correlations produced vanish in direct detection experiments. On the other hand, we show that in scenarios where the B-mode of the CMB is sourced by gravitational waves generated by a global phase transition, a strong 3-pt signal among the polarization modes could also be produced. This may provide another method of distinguishing inflationary B-modes. To carry out this computation, we have developed a diagrammatic approach to the calculation of stochastic gravitational waves sourced by scalar fluids, which has applications beyond the present scenario., Comment: 16 pages, 5 figures

Given a scalar field with metastable minima, bubbles nucleate quantum mechanically. When bubbles collide, energy stored in the bubble walls is converted into kinetic energy of the field. This kinetic energy can facilitate the classical nucleation of new bubbles in minima that lie below those of the "parent" bubbles. This process is efficient and classical, and changes the dynamics and statistics of bubble formation in models with multiple vacua, relative to that derived from quantum tunneling., Comment: 4 pages, 4 figures, animations related to figures can be found at http://www.perimeterinstitute.ca/personal/jgiblin/BubbleMovies.html

We describe an efficient scheme for evaluating higher order contributions to primordial cosmological perturbations using the "in-in" formalism, which is the basis of modern calculations of non-Gaussian and higher order contributions to the primordial spectrum. We show that diagrams with two or more vertices require careful handling. We present an implementation of the operator formalism in which these diagrams can be evaluated in a simple and transparent fashion. We illustrate our methodology by evaluating the correction to the primordial gravitational wave spectrum generated by scalar loops, a 2-vertex, 1-loop interaction. We then look at a generalized $N$-point, 2-vertex diagram., Comment: 9 pages. 2 figures. Minor revisions. Submitted to PRD

How did the universe evolve? The fine angular scale (l>1000) temperature and polarization anisotropies in the CMB are a Rosetta stone for understanding the evolution of the universe. Through detailed measurements one may address everything from the physics of the birth of the universe to the history of star formation and the process by which galaxies formed. One may in addition track the evolution of the dark energy and discover the net neutrino mass. We are at the dawn of a new era in which hundreds of square degrees of sky can be mapped with arcminute resolution and sensitivities measured in microKelvin. Acquiring these data requires the use of special purpose telescopes such as the Atacama Cosmology Telescope (ACT), located in Chile, and the South Pole Telescope (SPT). These new telescopes are outfitted with a new generation of custom mm-wave kilo-pixel arrays. Additional instruments are in the planning stages., Comment: Science White Paper submitted to the US Astro2010 Decadal Survey. Full list of 177 author available at http://cmbpol.uchicago.edu

We summarize the utility of precise cosmic microwave background (CMB) polarization measurements as probes of the physics of inflation. We focus on the prospects for using CMB measurements to differentiate various inflationary mechanisms. In particular, a detection of primordial B-mode polarization would demonstrate that inflation occurred at a very high energy scale, and that the inflaton traversed a super-Planckian distance in field space. We explain how such a detection or constraint would illuminate aspects of physics at the Planck scale. Moreover, CMB measurements can constrain the scale-dependence and non-Gaussianity of the primordial fluctuations and limit the possibility of a significant isocurvature contribution. Each such limit provides crucial information on the underlying inflationary dynamics. Finally, we quantify these considerations by presenting forecasts for the sensitivities of a future satellite experiment to the inflationary parameters., Comment: 107 pages, 14 figures, 17 tables; Inflation Working Group contribution to the CMBPol Mission Concept Study; v2: typos fixed and references added