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Your search keyword '"Li, Wenqiang"' showing total 2,281 results
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2,281 results on '"Li, Wenqiang"'

260. Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Author

Jiang, Wenhua, primary, Hou, Qiangqiang, additional, Xu, Hongrui, additional, Yang, Kexin, additional, Wang, Xiaohui, additional, Zhang, Kuojun, additional, Zeng, Yi, additional, Li, Wenqiang, additional, Wang, Bingrui, additional, Luo, Guangmei, additional, Zhao, Xiaofan, additional, Shen, Hui, additional, Xu, Yong, additional, and Wu, Xiaoxing, additional

Published
2024
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276. ZmWAK02 encoding an RD‐WAK protein confers maize resistance against gray leaf spot

Author

Dai, Zhikang, primary, Pi, Qianyu, additional, Liu, Yutong, additional, Hu, Long, additional, Li, Bingchen, additional, Zhang, Bao, additional, Wang, Yanbo, additional, Jiang, Min, additional, Qi, Xin, additional, Li, Wenqiang, additional, Gui, Songtao, additional, Llaca, Victor, additional, Fengler, Kevin, additional, Thatcher, Shawn, additional, Li, Ziwei, additional, Liu, Xiangguo, additional, Fan, Xingming, additional, and Lai, Zhibing, additional

Published
2023
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283. Real-time and noninvasive tracking of injectable hydrogel degradation using functionalized AIE nanoparticles

Author

Zhang Mengdi, Wang Zengliang, Huang Pengzhou, Jiang Guanwei, Xu Changpeng, Zhang Wentao, Guo Rui, Li Wenqiang, and Zhang Xintao

Subjects
hydrogel degradation, aggregation-induced emission (aie), tetraphenylethene (tpe), mesoporous dopamine microspheres (mpdas), photoacoustic imaging, Physics, QC1-999
Abstract

Visually monitoring of the residual morphology and quantitatively determining the degradation degree of hydrogels applied in tissue repair therapy in a real-time and noninvasive manner were a crucial technological mean. Despite conventional organic fluorescent molecules commonly used as probe to capture the real-time clues of the labeled hydrogels, they still encounter obstacles, including intrinsic photobleaching, cytotoxicity, and unknown interference factor of degradation caused by the change from polymer structure of hydrogels, thus making it difficult to accurately obtain the information of the hydrogels in vivo. To address the hard nut, we designed the multifunctional hydrogel system with a real-time quantitative aggregation-induced emission fluorescent detection and photoacoustic imaging tracking based on tetraphenylethene (TPE) that possesses the trait of aggregation-induced emission and low photobleaching, bound on the surface of mesoporous dopamine microspheres (MPDAs), and subsequently loaded into the photo-crosslinked injectable hydrogels. In vitro results showed that MPDA-TPE had good compatibility, emitted strong fluorescence when embedded in hydrogels, and maintained stable fluorescence property unless the hydrogels were degraded. Meanwhile, a mathematical formula for the kinetic degradation of hydrogels was established between gravitational and visual degradation in vitro, which can be used to predict in vivo degradation. Furthermore, MPDA possessed the clear photoacoustic imaging effect to provide more accurate clues. The designed hydrogel system holds a potential role in prediction of the in vivo degradation of implanted materials in an accurate, convenient, and real-time noninvasive manner and is a meaningful treatment aid in tissue engineering.

Published
2020
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284. Neural stem cell secretome and its role in the treatment of neurodegenerative disorders

Author

Qian Zhang, Jia Li , Wenqiang An, Yiou Fan, Qilong Cao

Subjects
neuroplasticity, bystander effect, secretome, neurodegenerative disorders, neural stem cell, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Neurological diseases in the central nervous system are mostly characterized by the failure of endogenous repair to restore tissue damage and salvage lost function. Currently, studies have shown that neural stem cell transplantation provides a good therapeutic effect on neurological diseases. For this reason, neural stem cell transplantation has been explored as a cell replacement therapy. Although transplanted cells can replace cells lost during or post central nervous system injury, many studies have shown that this mechanism is insufficient as most of these newly formed cells fail to integrate and eventually die. Although it was initially thought that neural stem cell could only replace lost cells, recent experiments have shown that transplanted neural stem cell can also play bystander roles such as neuroprotection and immune regulation, promote tissue repair by preventing tissue damage, interfere with pathogenic processes, or by rescuing endogenous nerve cells. However, compelling evidence has raised concerns about this bystander effect, which can be caused by several biologically active molecules (collectively known as the secretome) produced by neural stem cells. These results also raise the possibility of the neural stem cell secretome as a potential candidate for neural stem cell transplantation therapies based on the bystander effect. A better understanding of the molecules and mechanisms of this effect is of critical importance for neural stem cell-based therapies. This review aims to discuss the function and application of neural stem cell secretome in the treatment of neurodegenerative disorders.

Published
2020
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