1,197 results on '"Leitzmann, Michael F"'
Search Results
252. Gallstones and incident colorectal cancer in a large pan‐European cohort study
- Author
-
Ward, Heather A, primary, Murphy, Neil, additional, Weiderpass, Elisabete, additional, Leitzmann, Michael F, additional, Aglago, Elom, additional, Gunter, Marc J, additional, Freisling, Heinz, additional, Jenab, Mazda, additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Carbonnel, Franck, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Merino, Susana, additional, Zamora‐Ros, Raul, additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, Maria‐Dolores, additional, Barricarte, Aurelio, additional, Perez‐Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Bueno‐de‐Mesquita, Bas, additional, Vermeulen, Roel, additional, Van Gils, Carla, additional, Nyström, Hanna, additional, Rutegård, Martin, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, and Cross, Amanda J, additional
- Published
- 2019
- Full Text
- View/download PDF
253. Use of statins or NSAIDs and survival of patients with high-grade glioma
- Author
-
Seliger, Corinna, primary, Schaertl, Julia, additional, Gerken, Michael, additional, Luber, Christian, additional, Proescholdt, Martin, additional, Riemenschneider, Markus J., additional, Leitzmann, Michael F., additional, Hau, Peter, additional, and Klinkhammer-Schalke, Monika, additional
- Published
- 2018
- Full Text
- View/download PDF
254. The Relation of Physical Activity to Risk for Symptomatic Gallstone Disease in Men
- Author
-
Leitzmann, Michael F., Giovannucci, Edward L., Rimm, Eric B., Stampfer, Meir J., Spiegelman, Donna, Wing, Alvin L., and Willett, Walter C.
- Published
- 1998
255. Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study
- Author
-
Ekelund Ulf, Wareham Nicholas J, Gierach Gretchen L, Moore Steven C, Peters Tricia M, Hollenbeck Albert R, Schatzkin Arthur, and Leitzmann Michael F
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Despite strong evidence of an inverse association of physical activity with postmenopausal breast cancer risk, whether a certain intensity or time of life of physical activity is most effective for lowering breast cancer risk is not known. Methods In 118,899 postmenopausal women in the prospective NIH-AARP Diet and Health Study, we examined the relations of light and moderate-to-vigorous intensity physical activity during four periods of life ("historical": ages 15-18, 19-29, 35-39 years; "recent": past 10 years) to postmenopausal breast cancer risk. Physical activity was assessed by self-report at baseline, and 4287 incident breast cancers were identified over 6.6 years of follow-up. Results In age-adjusted and multivariate Cox regression models, >7 hours/week of moderate-to-vigorous activity during the past 10 years was associated with 16% reduced risk of postmenopausal breast cancer (RR:0.84; 95%CI:0.76,0.93) compared with inactivity. The association remained statistically significant after adjustment for BMI (RR:0.87; 95%CI:0.78,0.96). Neither moderate-to-vigorous activity during other periods of life nor light intensity activity during any period of life was related to breast cancer risk, and associations did not vary by tumor characteristics. Conclusion A high level of recent, but not historical, physical activity of moderate-to-vigorous intensity is associated with reduced postmenopausal breast cancer risk. More precise recall of recent physical activity than activity in the distant past is one possible explanation for our findings.
- Published
- 2009
- Full Text
- View/download PDF
256. Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort
- Author
-
Leitzmann Michael F, Chang Shih-Chen, Marcus Pamela M, Buys Saundra S, Kreimer Aimee R, Lacey James V, Hoover Robert N, Prorok Philip C, Berg Christine D, and Hartge Patricia
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Multidisciplinary attempts to understand the etiology of breast cancer are expanding to increasingly include new potential markers of disease risk. Those efforts may have maximal scientific and practical influence if new findings are placed in context of the well-understood lifestyle and reproductive risk factors or existing risk prediction models for breast cancer. We therefore evaluated known risk factors for breast cancer in a cancer screening trial that does not have breast cancer as a study endpoint but is large enough to provide numerous analytic opportunities for breast cancer. Methods We evaluated risk factors for breast cancer (N = 2085) among 70,575 women who were randomized in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Using Poisson regression, we calculated adjusted relative risks [RRs, with 95% confidence intervals (CIs)] for lifestyle and reproductive factors during an average of 5 years of follow-up from date of randomization. Results As expected, increasing age, nulliparity, positive family history of breast cancer, and use of menopausal hormone therapy were positively associated with breast cancer. Later age at menarche (16 years or older vs. < 12: RR = 0.81, 95% CI, 0.65–1.02) or menopause (55 years or older vs. < 45: RR = 1.29, 95% CI, 1.03–1.62) were less strongly associated with breast cancer than was expected. There were weak positive associations between taller height and heavier weight, and only severe obesity [body mass index (BMI; kg/m2) 35 or more vs. 18.5–24.9: RR = 1.21, 95% CI, 1.02–1.43] was statistically significantly associated with breast cancer. Conclusion The ongoing PLCO trial offers continued opportunities for new breast cancer investigations, but these analyses suggest that the associations between breast cancer and age at menarche, age at menopause, and obesity might be changing as the underlying demographics of these factors change. Clinical Trials Registration http://www.clinicaltrials.gov, NCT00002540.
- Published
- 2009
- Full Text
- View/download PDF
257. Physical activity and the risk of heart failure: a systematic review and dose–response meta-analysis of prospective studies.
- Author
-
Aune, Dagfinn, Schlesinger, Sabrina, Leitzmann, Michael F., Tonstad, Serena, Norat, Teresa, Riboli, Elio, and Vatten, Lars J.
- Subjects
CARDIOVASCULAR fitness ,PHYSICAL activity ,HEART failure ,META-analysis ,CORONARY disease ,CARDIOPULMONARY fitness ,RANDOM effects model - Abstract
Although physical activity is an established protective factor for cardiovascular diseases such as ischemic heart disease and stroke, less is known with regard to the association between specific domains of physical activity and heart failure, as well as the association between cardiorespiratory fitness and heart failure. We conducted a systematic review and meta-analysis of prospective observational studies to clarify the relations of total physical activity, domains of physical activity and cardiorespiratory fitness to risk of heart failure. PubMed and Embase databases were searched up to January 14th, 2020. Summary relative risks (RRs) were calculated using random effects models. Twenty-nine prospective studies (36 publications) were included in the review. The summary RRs for high versus low levels were 0.77 (95% CI 0.70–0.85, I
2 = 49%, n = 7) for total physical activity, 0.74 (95% CI 0.68–0.81, I2 = 88.1%, n = 16) for leisure-time activity, 0.66 (95% CI 0.59–0.74, I2 = 0%, n = 2) for vigorous activity, 0.81 (95% CI 0.69–0.94, I2 = 86%, n = 3) for walking and bicycling combined, 0.90 (95% CI 0.86–0.95, I2 = 0%, n = 3) for occupational activity, and 0.31 (95% CI 0.19–0.49, I2 = 96%, n = 6) for cardiorespiratory fitness. In dose–response analyses, the summary RRs were 0.89 (95% CI 0.83–0.95, I2 = 67%, n = 4) per 20 MET-hours per day of total activity and 0.71 (95% CI 0.65–0.78, I2 = 85%, n = 11) per 20 MET-hours per week of leisure-time activity. Nonlinear associations were observed in both analyses with a flattening of the dose–response curve at 15–20 MET-hours/week for leisure-time activity. These findings suggest that high levels of total physical activity, leisure-time activity, vigorous activity, occupational activity, walking and bicycling combined and cardiorespiratory fitness are associated with reduced risk of developing heart failure. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
258. Anthropometric risk factors for ovarian cancer in the NIH-AARP Diet and Health Study.
- Author
-
Baumeister, Sebastian E., Schlecht, Inga, Trabert, Britton, Nolde, Michael, Meisinger, Christa, and Leitzmann, Michael F.
- Subjects
OVARIAN cancer ,OVARIAN epithelial cancer ,BODY mass index ,BODY composition ,WAIST-hip ratio ,WAIST circumference - Abstract
Objective: Identifying potentially modifiable risk factors for ovarian cancer is essential for prevention because this cancer is predominantly detected at a late stage. Here, we estimated the relations of general adiposity and measures reflecting body fat distribution to the risk of epithelial ovarian cancer.Methods: We ascertained 683 ovarian epithelial cancers (343 high-grade serous, 141 non-high grade serous) among 145,575 women, aged 50-72 years (median follow-up 12.6 years), from the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study. Using Cox models, we estimated confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for associations of overall ovarian cancer, high-grade serous and non-high-grade serous carcinoma with body mass index, waist circumference, hip circumference, waist-hip ratio, waist-height ratio, body adiposity index, body shape index, and abdominal volume index.Results: Anthropometric measures were unrelated to overall ovarian cancer, high-grade serous cancer, and non-high-grade serous cancer. For example, the HR for overall ovarian cancer per standard deviation increment of body mass index at baseline was 0.98 (95% CI 0.88-1.10). Similar associations were observed with measurements of body fat distribution.Conclusion: These results do not indicate that adult adiposity is associated with ovarian cancer risk in post-menopausal women. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
259. Relation of body fat mass and fat-free mass to total mortality: results from 7 prospective cohort studies.
- Author
-
Sedlmeier, Anja M, Baumeister, Sebastian E, Weber, Andrea, Fischer, Beate, Thorand, Barbara, Ittermann, Till, Dörr, Marcus, Felix, Stephan B, Völzke, Henry, Peters, Annette, and Leitzmann, Michael F
- Subjects
MORTALITY risk factors ,BODY composition ,CONFIDENCE intervals ,LEAN body mass ,RISK assessment ,SOCIOECONOMIC factors ,PHYSICAL activity ,DESCRIPTIVE statistics ,ADIPOSE tissues ,LONGITUDINAL method ,PROPORTIONAL hazards models - Abstract
Background Fat mass and fat-free mass may play independent roles in mortality risk but available studies on body composition have yielded inconsistent results. Objective The aim was to determine the relations of body fat mass and fat-free mass to risk of mortality. Methods In pooled data from 7 prospective cohorts encompassing 16,155 individuals aged 20 to 93 y (median, 44 y), we used Cox regression and restricted cubic splines to estimate HRs and 95% CIs for the relation of body composition, measured by bioelectrical impedance analysis, to total mortality. We adjusted for age, study, sex, ethnicity, history of diabetes mellitus, education, smoking, physical activity, and alcohol consumption. Results During a median follow-up period of 14 y (range, 3–21 y), 1347 deaths were identified. After mutual adjustment for fat mass and fat-free mass, fat mass showed a J-shaped association with mortality (overall P value < 0.001; P for nonlinearity = 0.003). Using a fat mass index of 7.3 kg/m
2 as the reference, a high fat mass index of 13.0 kg/m2 was associated with an HR of 1.56 (95% CI: 1.30, 1.87). In contrast, fat-free mass showed an inverse association with mortality (overall P value < 0.001; P for nonlinearity = 0.001). Compared with a low fat-free mass index of 16.1 kg/m2 , a high fat-free mass of 21.9 kg/m2 was associated with an HR of 0.70 (95% CI: 0.56, 0.87). Conclusions Fat mass and fat-free mass show opposing associations with mortality. Excess fat mass is related to increased mortality risk, whereas fat-free mass protects against risk of mortality. These findings suggest that body composition provides important prognostic information on an individual's mortality risk not provided by traditional proxies of adiposity such as BMI. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
260. A prospective study of physical activity and the risk of pancreatic cancer among women (United States)
- Author
-
Schairer Catherine, Schatzkin Arthur, Moore Steven C, Stolzenberg-Solomon Rachael Z, Calton Brook A, Albanes Demetrius, and Leitzmann Michael F
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent. Methods This study examined the associations of total, moderate, and vigorous physical activity to pancreatic cancer in a cohort of 33,530 U.S. women enrolled in the Breast Cancer Detection Demonstration Project (BCDDP). At baseline (1987–1989), information on physical activity over the past year was obtained using a self-administered questionnaire. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals of pancreatic cancer risk. Results 70 incident cases of pancreatic cancer were ascertained during 284,639 person years of follow-up between 1987–1989 and 1995–1998. After adjustment for age, body mass index, smoking status, history of diabetes, and height, increased physical activity was related to a suggestively decreased risk of pancreatic cancer. The RRs for increasing quartiles of total physical activity were 1.0, 0.80, 0.66, 0.52 (95% CI = 0.26, 1.05; ptrend = 0.05). This association was consistent across subgroups defined by body mass index and smoking status. We also observed statistically non-significant reductions in pancreatic cancer risk for women in the highest quartile of moderate (RR = 0.57; 95% CI = 0.26, 1.26) and highest quartile of vigorous physical activity (RR = 0.63; 95% CI = 0.31, 1.28) compared to their least active counterparts. Conclusion Our study provides evidence for a role of physical activity in protecting against pancreatic cancer.
- Published
- 2008
- Full Text
- View/download PDF
261. Sedentary behaviour epidemiology
- Author
-
Leitzmann, Michael F., editor, Jochem, Carmen, editor, Schmid, Daniela, editor, Leitzmann, Michael F., editor, Jochem, Carmen, editor, and Schmid, Daniela, editor
- Published
- 2018
262. Diabetes, use of metformin, and the risk of meningioma
- Author
-
Leitzmann, Michael F., Seliger, Corinna, Meier, Christoph R., Becker, Claudia, Jick, Susan S., Proescholdt, Martin, Bogdahn, Ulrich, and Hau, Peter
- Subjects
Male ,Databases, Factual ,Physiology ,Myocardial Infarction ,610 Medizin ,lcsh:Medicine ,Blood Pressure ,Biochemistry ,Vascular Medicine ,Body Mass Index ,Endocrinology ,Risk Factors ,Medicine and Health Sciences ,Diabetes diagnosis and management ,Meningeal Neoplasms ,Odds Ratio ,Insulin ,lcsh:Science ,Child ,Neurological Tumors ,Aged, 80 and over ,PRACTICE RESEARCH DATABASE ,BRAIN-TUMORS ,GLIOMA ,ADULTS ,METAANALYSIS ,ASSOCIATION ,POPULATION ,THERAPY ,HISTORY ,CANCER ,ddc:610 ,Middle Aged ,Metformin ,Oncology ,Neurology ,Physiological Parameters ,Child, Preschool ,Hypertension ,Female ,Meningioma ,Research Article ,Adult ,HbA1c ,Adolescent ,Endocrine Disorders ,Cardiology ,Young Adult ,Diabetes Mellitus ,Humans ,Hypoglycemic Agents ,Hemoglobin ,Aged ,Diabetic Endocrinology ,Glycated Hemoglobin ,Biology and life sciences ,lcsh:R ,Body Weight ,Infant, Newborn ,Cancers and Neoplasms ,Proteins ,Infant ,Estrogens ,Diagnostic medicine ,Hormones ,Sulfonylurea Compounds ,Metabolic Disorders ,Case-Control Studies ,lcsh:Q - Abstract
Background Metformin is a commonly used oral antidiabetic agent that has been associated with decreased cancer risk. However, data regarding the association between metformin use and the risk of meningioma are unavailable. Methods We conducted a matched case-control analysis using data from the U. K.-based Clinical Practice Research Datalink (CPRD) to analyse diabetes status, duration of diabetes, glycemic control, and use of metformin, sulfonylureas, and insulin in relation to the risk of meningioma. We conducted conditional logistic regression analyses to determine relative risks, estimated as odds ratios (ORs) with 95% confidence intervals (CIs) and adjusted for body mass index, smoking, history of arterial hypertension, myocardial infarction, and use of estrogens (among women). Results We identified 2,027 meningioma cases and 20,269 controls. For diabetes there was the suggestion of an inverse association with meningioma (OR = 0.89; 95% CI = 0.74 - 1.07), which was driven by an inverse relation among women (OR = 0.78; 95% CI = 0.62 - 0.98), in whom we also noted a suggestive inverse association with duration of diabetes (p-value for trend = 0.071). For metformin there was a suggestive positive relation, particularly after matching on duration of diabetes and HbA1c level (OR = 1.64; 95% CI = 0.89 - 3.04). Sulfonylureas showed no clear association (OR = 0.91; 95% CI = 0.46 - 1.80). For insulin there was the suggestion of an inverse relation, in particular when comparing a high vs. low number of prescriptions (OR = 0.58; 95% CI = 0.18 - 1.83). Conclusion Further studies are needed to solidify a possible inverse association between diabetes and meningioma risk and to clarify the role of antidiabetics in this context.
- Published
- 2017
263. Design and evaluation of a computer-based 24-Hour physical activity recall (cpar24) instrument
- Author
-
Kohler, Simone, Behrens, Gundula, Olden, Matthias, Baumeister, Sebastian E., Horsch, Alexander, Fischer, Beate, and Leitzmann, Michael F.
- Subjects
usability ,ddc:610 ,validity ,reliability ,VDP::Teknologi: 500::Medisinsk teknologi: 620 ,sedentary behavior ,610 Medizin ,DOUBLY-LABELED WATER ,ESTIMATING ENERGY-EXPENDITURE ,ACTIVITY DIARY ,HEART-RATE ,ACTIVITY QUESTIONNAIRES ,ACTIVITY MONITORS ,FREQUENCY QUESTIONNAIRE ,EPIDEMIOLOGIC RESEARCH ,ACCELEROMETER OUTPUT ,SEDENTARY BEHAVIORS ,web-based method ,lifestyle behavior ,physical activity ,VDP::Technology: 500::Medical technology: 620 - Abstract
This is the published version of the following article: Kohler, S., Behrens, G., Olden, M., Baumeister, S.E., Horsch, A., Fischer, B. & Leitzmann, M.F. (2017). Design and evaluation of a computer-based 24-Hour physical activity recall (cpar24) instrument. Journal of Medical Internet Research, 19:e186(5), 1-17. https://doi.org/10.2196/jmir.7620, available at https://doi.org/10.2196/jmir.7620. Licensed CC BY-NC-ND 4.0. Background: Widespread access to the Internet and an increasing number of Internet users offers the opportunity of using Web-based recalls to collect detailed physical activity data in epidemiologic studies. Objective: The aim of this investigation was to evaluate the validity and reliability of a computer-based 24-hour physical activity recall (cpar24) instrument with respect to the recalled 24-h period. Methods: A random sample of 67 German residents aged 22 to 70 years was instructed to wear an ActiGraph GT3X+ accelerometer for 3 days. Accelerometer counts per min were used to classify activities as sedentary ( Results: As compared with accelerometry, the cpar24 underestimated light activity by −123 min (median difference, P difference Conclusion: These data show that the cpar24 is a valid and reproducible Web-based measure of physical activity in adults.
- Published
- 2017
264. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort
- Author
-
Carayol, Marion Leitzmann, Michael F. Ferrari, Pietro and Zamora-Ros, Raul Achaintre, David Stepien, Magdalena and Schmidt, Julie A. Travis, Ruth C. Overvad, Kim Tjonneland, Anne Hansen, Louise Kaaks, Rudolf Kuehn, Tilman Boein, Heiner Bachlechner, Ursula Trichoroulou, Antonia Bamia, Christina Palli, Domenico Agnoli, Claudia Tumino, Rosario and Vineis, Paolo Panico, Salvatore Quiros, J. Ramon and Sanchez-Cantalejo, Emilio Huerta, Jose Maria Ardanaz, Eva and Arriola, Larraitz Agudo, Antonio Nilsson, Jan Melander, E. and Bueno-de-Mesquita, Bas Peeters, Petra H. Wareham, Nick and Khaw, Kay-Tee Jenab, Mazda Key, Timothy J. Scalbert, Augustin Rinaldi, Sabina
- Abstract
Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
- Published
- 2017
265. Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank.
- Author
-
Hillreiner, Andrea, Baumeister, Sebastian E., Sedlmeier, Anja M., Finger, Jonas D., Schlitt, Hans J., and Leitzmann, Michael F.
- Subjects
CARDIOVASCULAR fitness ,COLORECTAL cancer ,CARDIOPULMONARY fitness ,TYPE 2 diabetes ,RECTAL cancer ,HEART beat - Abstract
Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifically has received very little attention. We examined the relation of cardiorespiratory fitness to colorectal cancer in 59,191 UK Biobank participants aged 39–70 years without prevalent cancer at baseline, followed from 2009 to 2014. Submaximal bicycle ergometry was conducted at study entry, and cardiorespiratory fitness was defined as physical work capacity at 75% of the maximum heart rate, standardised to body mass (PWC
75% ). Multivariable Cox proportional hazards regression was performed to obtain hazard ratios (HR) and corresponding 95% confidence intervals (CI). During a mean follow-up of 4.6 years, 232 participants developed colorectal cancer (151 colon cancers; 79 rectal cancers). When comparing the 75th to the 25th percentiles of PWC75% , the multivariable-adjusted HR of colorectal cancer was 0.78 (95% CI 0.62–0.97). That relation was largely driven by an inverse association with colon cancer (HR 0.74, 95% CI 0.56–0.97) and less so with rectal cancer (HR 0.88, 95% CI 0.62–1.26; p value for difference by colorectal cancer endpoint = 0.056). The inverse relation of cardiorespiratory fitness with colorectal cancer was more evident in men (HR 0.72, 95% CI 0.55–0.94) than women (HR 0.99, 95% CI 0.71–1.38), although the gender difference was not statistically significant (p value for interaction = 0.192). Increased cardiorespiratory fitness is associated with decreased risk of colorectal cancer. Potential heterogeneity by colorectal cancer anatomic subsite and gender requires further study. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
266. Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma.
- Author
-
Anssar, Tareq M., Leitzmann, Michael F., Linker, Ralf A., Meier, Christoph, Becker, Claudia, Jick, Susan, Sahm, Katharina, Platten, Michael, Hau, Peter, and Seliger, Corinna
- Subjects
- *
AUTOIMMUNE diseases , *SUBSTANCE-induced disorders , *INFLAMMATORY bowel diseases , *GLIOMAS - Abstract
Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune‐surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well‐validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune‐related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86‐1.11), allergy (OR 0.97, 95% CI 0.89‐1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31‐5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58‐0.91) and between long‐term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53‐0.96). [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
267. Body mass index trajectories across adulthood and smoking in relation to prostate cancer risks: the NIH-AARP Diet and Health Study
- Author
-
Kelly, Scott P, primary, Lennon, Hannah, additional, Sperrin, Matthew, additional, Matthews, Charles, additional, Freedman, Neal D, additional, Albanes, Demetrius, additional, Leitzmann, Michael F, additional, Renehan, Andrew G, additional, and Cook, Michael B, additional
- Published
- 2018
- Full Text
- View/download PDF
268. Use of metformin and survival of patients with high-grade glioma
- Author
-
Seliger, Corinna, primary, Luber, Christian, additional, Gerken, Michael, additional, Schaertl, Julia, additional, Proescholdt, Martin, additional, Riemenschneider, Markus J., additional, Meier, Christoph R., additional, Bogdahn, Ulrich, additional, Leitzmann, Michael F., additional, Klinkhammer-Schalke, Monika, additional, and Hau, Peter, additional
- Published
- 2018
- Full Text
- View/download PDF
269. Cancers Due to Excess Weight, Low Physical Activity, and Unhealthy Diet
- Author
-
Behrens, Gundula, primary, Gredner, Thomas, additional, Stock, Christian, additional, Leitzmann, Michael F., additional, Brenner, Hermann, additional, and Mons, Ute, additional
- Published
- 2018
- Full Text
- View/download PDF
270. Physical activity volume in relation to risk of atrial fibrillation. A non-linear meta-regression analysis
- Author
-
Ricci, Cristian, primary, Gervasi, Federico, additional, Gaeta, Maddalena, additional, Smuts, Cornelius M, additional, Schutte, Aletta E, additional, and Leitzmann, Michael F, additional
- Published
- 2018
- Full Text
- View/download PDF
271. Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention
- Author
-
Mahabir, Somdat, primary, Willett, Walter C., additional, Friedenreich, Christine M., additional, Lai, Gabriel Y., additional, Boushey, Carol J., additional, Matthews, Charles E., additional, Sinha, Rashmi, additional, Colditz, Graham A., additional, Rothwell, Joseph A., additional, Reedy, Jill, additional, Patel, Alpa V., additional, Leitzmann, Michael F., additional, Fraser, Gary E., additional, Ross, Sharon, additional, Hursting, Stephen D., additional, Abnet, Christian C., additional, Kushi, Lawrence H., additional, Taylor, Philip R., additional, and Prentice, Ross L., additional
- Published
- 2018
- Full Text
- View/download PDF
272. Physical activity, mediating factors and risk of colon cancer : Insights into adiposity and circulating biomarkers from the EPIC cohort
- Author
-
Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, Boeing, Heiner, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
- Published
- 2017
273. Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort
- Author
-
Carayol, Marion, Leitzmann, Michael F., Ferrari, Pietro, Zamora-Ros, Raul, Achaintre, David, Stepien, Magdalena, Schmidt, Julie A., Travis, Ruth C., Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Quirós, José Ramón, Sánchez-Cantalejo, Emilio, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Agudo, Antonio, Nilsson, Jan, Melander, Olle, Bueno-De-Mesquita, Bas, Peeters, Petra H., Wareham, Nick, Khaw, Kay Tee, Jenab, Mazda, Key, Timothy J., Scalbert, Augustin, Rinaldi, Sabina, Carayol, Marion, Leitzmann, Michael F., Ferrari, Pietro, Zamora-Ros, Raul, Achaintre, David, Stepien, Magdalena, Schmidt, Julie A., Travis, Ruth C., Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Quirós, José Ramón, Sánchez-Cantalejo, Emilio, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Agudo, Antonio, Nilsson, Jan, Melander, Olle, Bueno-De-Mesquita, Bas, Peeters, Petra H., Wareham, Nick, Khaw, Kay Tee, Jenab, Mazda, Key, Timothy J., Scalbert, Augustin, and Rinaldi, Sabina
- Published
- 2017
274. Physical activity, mediating factors and risk of colon cancer: Insights into adiposity and circulating biomarkers from the EPIC cohort
- Author
-
UMC Utrecht, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, Boeing, Heiner, UMC Utrecht, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
- Published
- 2017
275. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort
- Author
-
UMC Utrecht, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Carayol, Marion, Leitzmann, Michael F., Ferrari, Pietro, Zamora-Ros, Raul, Achaintre, David, Stepien, Magdalena, Schmidt, Julie A., Travis, Ruth C., Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Quirós, José Ramón, Sánchez-Cantalejo, Emilio, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Agudo, Antonio, Nilsson, Jan, Melander, Olle, Bueno-De-Mesquita, Bas, Peeters, Petra H., Wareham, Nick, Khaw, Kay Tee, Jenab, Mazda, Key, Timothy J., Scalbert, Augustin, Rinaldi, Sabina, UMC Utrecht, MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Carayol, Marion, Leitzmann, Michael F., Ferrari, Pietro, Zamora-Ros, Raul, Achaintre, David, Stepien, Magdalena, Schmidt, Julie A., Travis, Ruth C., Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Bamia, Christina, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Quirós, José Ramón, Sánchez-Cantalejo, Emilio, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Agudo, Antonio, Nilsson, Jan, Melander, Olle, Bueno-De-Mesquita, Bas, Peeters, Petra H., Wareham, Nick, Khaw, Kay Tee, Jenab, Mazda, Key, Timothy J., Scalbert, Augustin, and Rinaldi, Sabina
- Published
- 2017
276. Re: Body Mass Index and Risk of Lung Cancer Among Never, Former, and Current Smokers
- Author
-
Renehan, Andrew G., Leitzmann, Michael F., Zwahlen, Marcel, Renehan, Andrew G., Leitzmann, Michael F., and Zwahlen, Marcel
- Published
- 2017
277. The use and interpretation of anthropometric measures in cancer epidemiology: A perspective from the world cancer research fund international continuous update project
- Author
-
Bandera, Elisa V, Fay, Stephanie H, Giovannucci, Edward, Leitzmann, Michael F, Marklew, Rachel, McTiernan, Anne, Mullee, Amy, Romieu, Isabelle, Thune, Inger, Uauy, Ricardo, Wiseman, Martin J, and World Cancer Research Fund International Continuous Update Proje
- Abstract
Anthropometric measures relating to body size, weight and composition are increasingly being associated with cancer risk and progression. Whilst practical in epidemiologic research, where population-level associations with disease are revealed, it is important to be aware that such measures are imperfect markers of the internal physiological processes that are the actual correlates of cancer development. Body mass index (BMI), the most commonly used marker for adiposity, may mask differences between lean and adipose tissue, or fat distribution, which varies across individuals, ethnicities, and stage in the lifespan. Other measures, such as weight gain in adulthood, waist circumference and waist-to-hip ratio, contribute information on adipose tissue distribution and insulin sensitivity. Single anthropometric measures do not capture maturational events, including the presence of critical windows of susceptibility (i.e., age of menarche and menopause), which presents a challenge in epidemiologic work. Integration of experimental research on underlying dynamic genetic, hormonal, and other non-nutritional mechanisms is necessary for a confident conclusion of the overall evidence in cancer development and progression. This article discusses the challenges confronted in evaluating and interpreting the current evidence linking anthropometric factors and cancer risk as a basis for issuing recommendations for cancer prevention.
- Published
- 2016
278. Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma
- Author
-
Seliger, Corinna, Meier, Christoph R., Becker, Claudia, Jick, Susan S., Bogdahn, Ulrich, Hau, Peter, and Leitzmann, Michael F.
- Subjects
ddc:610 ,lcsh:R ,NONSTEROIDAL ANTIINFLAMMATORY DRUGS ,LOW-DOSE ASPIRIN ,NEWLY-DIAGNOSED GLIOBLASTOMA ,PHASE-II TRIAL ,COX-2 INHIBITION ,BRAIN-TUMORS ,MALIGNANT GLIOMA ,MEDICATION USE ,CELECOXIB ,CELLS ,610 Medizin ,lcsh:Medicine ,lcsh:Q ,lcsh:Science - Abstract
Background Selective cyclooxygenase-2 (COX-2) inhibitors are analgesic, antipyretic, and anti-inflammatory drugs. They have been found to inhibit the development of glioma in laboratory investigations. Whether these drugs reduce the risk of glioma incidence in humans is unknown. Methods We conducted a matched case-control analysis using the U.K.-based Clinical Practice Research Datalink (CPRD). We identified 2,469 cases matched to 24,690 controls on age, sex, calendar time, general practice, and number of years of active history in the CPRD prior to the index date. We conducted conditional logistic regression analyses to determine relative risks, estimated as odds ratios (ORs) with 95% confidence intervals (CIs) of glioma in relation to use of selective COX-2 inhibitors, adjusted for several confounding variables. Results Use of selective COX-2 inhibitors was unrelated to risk of glioma (adjusted OR for 1-9 versus 0 prescriptions = 1.02; 95% CI = 0.92-1.13, 10-29 versus 0 prescriptions = 1.01; 95% CI = 0.80-1.28, >= 30 versus 0 prescriptions = 1.16; 95% CI = 0.86-1.55). Trends for increasing numbers of prescriptions for other non-steroidal anti-inflammatory drugs (NSAIDs), and non-NSAID analgesics were also not associated with glioma risk. Conclusion Further epidemiologic studies are needed to confirm the null relation of use of selective COX-2 inhibitors to glioma risk and to explain the discrepancy between laboratory investigations and our observational study. Impact: Use of selective COX-2 inhibitors is unrelated to glioma risk.
- Published
- 2016
- Full Text
- View/download PDF
279. Physical activity surveillance in the European Union: reliability and validity of the European Health Interview Survey-PhysicalActivity Questionnaire (EHIS-PAQ)
- Author
-
Baumeister, Sebastian Edgar, Ricci, Cristian, Kohler, Simone, Fischer, Beate, Töpfer, Christine, Finger, Jonas D., and Leitzmann, Michael F.
- Subjects
ddc:610 ,Nutrition and Dietetics ,610 Medizin ,Medicine (miscellaneous) ,AMERICAN-HEART-ASSOCIATION ,CARDIORESPIRATORY FITNESS ,SEDENTARY BEHAVIOR ,NONCOMMUNICABLE DISEASES ,ADULTS ,ACCELEROMETER ,RECOMMENDATIONS ,VALIDATION ,INACTIVITY ,WORLDWIDE ,Validation ,Physical activity questionnaire ,Recommendations ,Population surveillance - Abstract
Background: The current study examined the reliability and validity of the European Health Interview Survey-Physical Activity Questionnaire (EHIS-PAQ), a novel questionnaire for the surveillance of physical activity (PA) during work, transportation, leisure time, sports, health-enhancing and muscle-strengthening activities over a typical week. Methods: Reliability was assessed by administering the 8-item questionnaire twice to a population-based sample of 123 participants aged 15-79 years at a 30-day interval. Concurrent (inter-method) validity was examined in 140 participants by comparisons with self-report (International Physical Activity Questionnaire-Long Form (IPAQ-LF), 7-day Physical Activity Record (PAR), and objective criterion measures (GT3X+accelerometer, physical work capacity at 75 % (PWC75%) from submaximal cycle ergometer test, hand grip strength). Results: The EHIS-PAQ showed acceptable reliability, with a median intraclass correlation coefficient across PA domains of 0.55 (range 0.43-0.73). Compared to the GT3X+ (counts/minutes/day), the EHIS-PAQ underestimated moderate-to-vigorous PA (median difference - 11.7, p-value = 0.054). Spearman correlation coefficients (.) for validity were moderate-to-strong (rho's > 0.41) for work-related PA (IPAQ = 0.64, GT3X + = 0.43, grip strength = 0.48), transportation-related PA (IPAQ = 0.62, GT3X + = 0.43), walking (IPAQ = 0.58), and health-enhancing PA (IPAQ = 0. 58, PAR = 0.64, GT3X + = 0.44, PWC75% = 0.48), and fair-to-poor (rho's < 0.41) for moderate-to-vigorous aerobic recreational and muscle-strengthening PA. Conclusions: The EHIS-PAQ showed good evidence for reliability and validity for the measurement of PA levels at work, during transportation and health-enhancing PA.
- Published
- 2016
- Full Text
- View/download PDF
280. Alcohol consumption and cardiorespiratory fitness in five population-based studies
- Author
-
Baumeister, Sebastian E, primary, Finger, Jonas D, additional, Gläser, Sven, additional, Dörr, Marcus, additional, Markus, Marcello RP, additional, Ewert, Ralf, additional, Felix, Stephan B, additional, Grabe, Hans-Jörgen, additional, Bahls, Martin, additional, Mensink, Gert BM, additional, Völzke, Henry, additional, Piontek, Katharina, additional, and Leitzmann, Michael F, additional
- Published
- 2017
- Full Text
- View/download PDF
281. Reply to JJ Meerpohl et al.
- Author
-
Schwingshackl, Lukas, primary, Knüppel, Sven, additional, Schwedhelm, Carolina, additional, Hoffmann, Georg, additional, Missbach, Benjamin, additional, Stelmach-Mardas, Marta, additional, Dietrich, Stefan, additional, Eichelmann, Fabian, additional, Kontopantelis, Evangelos, additional, Iqbal, Khalid, additional, Aleksandrova, Krasimira, additional, Lorkowski, Stefan, additional, Leitzmann, Michael F, additional, Kroke, Anja, additional, and Boeing, Heiner, additional
- Published
- 2017
- Full Text
- View/download PDF
282. An Evaluation of the Evidence Relating to Physical Inactivity, Sedentary Behavior, and Cancer Incidence and Mortality
- Author
-
Lynch, Brigid M., primary and Leitzmann, Michael F., additional
- Published
- 2017
- Full Text
- View/download PDF
283. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort
- Author
-
Carayol, Marion, primary, Leitzmann, Michael F., additional, Ferrari, Pietro, additional, Zamora-Ros, Raul, additional, Achaintre, David, additional, Stepien, Magdalena, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Bachlechner, Ursula, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Quirós, J. Ramón, additional, Sánchez-Cantalejo, Emilio, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Arriola, Larraitz, additional, Agudo, Antonio, additional, Nilsson, Jan, additional, Melander, Olle, additional, Bueno-de-Mesquita, Bas, additional, Peeters, Petra H., additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Jenab, Mazda, additional, Key, Timothy J., additional, Scalbert, Augustin, additional, and Rinaldi, Sabina, additional
- Published
- 2017
- Full Text
- View/download PDF
284. Domains of physical activity and brain volumes: A population-based study
- Author
-
Jochem, Carmen, primary, Baumeister, Sebastian E., additional, Wittfeld, Katharina, additional, Leitzmann, Michael F., additional, Bahls, Martin, additional, Schminke, Ulf, additional, Markus, Marcello R.P., additional, Felix, Stephan B., additional, Völzke, Henry, additional, Hegenscheid, Katrin, additional, Dörr, Marcus, additional, and Jörgen Grabe, Hans, additional
- Published
- 2017
- Full Text
- View/download PDF
285. Diabetes, use of metformin, and the risk of meningioma
- Author
-
Seliger, Corinna, primary, Meier, Christoph R., additional, Becker, Claudia, additional, Jick, Susan S., additional, Proescholdt, Martin, additional, Bogdahn, Ulrich, additional, Hau, Peter, additional, and Leitzmann, Michael F., additional
- Published
- 2017
- Full Text
- View/download PDF
286. Design and Evaluation of a Computer-Based 24-Hour Physical Activity Recall (cpar24) Instrument
- Author
-
Kohler, Simone, primary, Behrens, Gundula, additional, Olden, Matthias, additional, Baumeister, Sebastian E, additional, Horsch, Alexander, additional, Fischer, Beate, additional, and Leitzmann, Michael F, additional
- Published
- 2017
- Full Text
- View/download PDF
287. Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
- Author
-
Schlecht, Inga, primary, Gronwald, Wolfram, additional, Behrens, Gundula, additional, Baumeister, Sebastian E., additional, Hertel, Johannes, additional, Hochrein, Jochen, additional, Zacharias, Helena U., additional, Fischer, Beate, additional, Oefner, Peter J., additional, and Leitzmann, Michael F., additional
- Published
- 2017
- Full Text
- View/download PDF
288. Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies
- Author
-
Aune, Dagfinn, primary, Sen, Abhijit, additional, Leitzmann, Michael F., additional, Norat, Teresa, additional, Tonstad, Serena, additional, and Vatten, Lars J., additional
- Published
- 2017
- Full Text
- View/download PDF
289. Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population
- Author
-
Baumeister, Sebastian E., primary, Leitzmann, Michael F., additional, Bahls, Martin, additional, Dörr, Marcus, additional, Schmid, Daniela, additional, Schomerus, Georg, additional, Appel, Katja, additional, Markus, Marcello R. P., additional, Völzke, Henry, additional, Gläser, Sven, additional, and Grabe, Hans-Jörgen, additional
- Published
- 2017
- Full Text
- View/download PDF
290. The German AugUR study: study protocol of a prospective study to investigate chronic diseases in the elderly
- Author
-
Heid, Iris M., Stark, Klaus, Olden, Matthias, Brandl, Caroline, Dietl, Alexander, Zimmermann, Martina E., Schelter, Sabine C., Loss, Julika, Leitzmann, Michael F., Böger, Carsten A., Luchner, Andreas, Kronenberg, Florian, Helbig, Horst, and Weber, Bernhard H. F.
- Subjects
Male ,Aging ,Diseases of late onset ,Universities ,610 Medizin ,Etiology of chronic diseases ,Study Protocol ,Mobile elderly population ,Risk Factors ,Germany ,Surveys and Questionnaires ,Humans ,Genetic and non-genetic risk factors ,Prospective Studies ,Geriatric Assessment ,Life Style ,Cross-sectional study ,Aged ,Aged, 80 and over ,ddc:610 ,Cohort study ,Study platform ,Population Surveillance ,Chronic Disease ,Female ,Geriatrics and Gerontology ,Follow-Up Studies - Abstract
Background The majority of patients suffering from chronic health disabilities is beyond 70 years of age. Typical late-onset chronic diseases include those affecting the heart, the kidney, cancer, and conditions of the eye such as age-related macular degeneration. These diseases disable patients for many years and largely compromise autonomy in daily life. Due to challenges in recruiting the elderly, the collection of population-based epidemiological data as a prerequisite to understand associated risk factors and mechanisms is commonly done in the general population within an age-range of 20 to 70 years. Methods/Design We establish the German AugUR study (Age-related diseases: understanding genetic and non-genetic influences - a study at the University of Regensburg), a prospective study in the mobile elderly general population in and around Regensburg in eastern Bavaria. In the long term, we aim to recruit 3,000 persons of Caucasian ethnicity with at least 70 years of age via residents’ registration offices and conduct 3-year follow-ups. The study protocol includes a standardized interview regarding social and life-style factors, medication history, quality-of-life, and existing diagnoses of common diseases. The participants undergo medical examinations for ophthalmological, cardiovascular or diabetes-related conditions, and general measurements of body shape and fitness. The program is particularly tailored for the elderly. Biobanking of whole blood, serum, plasma, and urine is conducted and standard laboratory measurements are performed in fresh samples. Discussion AugUR is specifically designed as a research platform to host studies of late onset diseases. Consequently, this platform will help (1) to unravel the genetic and non-genetic etiology of disease development and progression, (2) to serve as control group of elderly individuals for comparisons with various patient groups, (3) to derive prevalence and incidence data on chronic diseases, and (4) to provide clinical reference parameters for the elderly mobile general population. This data will foster our understanding of disease mechanisms, which may ultimately help to improve prevention, diagnosis, and therapy for frequent chronic diseases. Here we present the baseline study protocol of AugUR.
- Published
- 2015
291. Physical Activity and Risk of Colon Cancer in Diabetic and Nondiabetic US Adults
- Author
-
Schmid, Daniela, primary, Behrens, Gundula, additional, Matthews, Charles E., additional, and Leitzmann, Michael F., additional
- Published
- 2016
- Full Text
- View/download PDF
292. Reply to Greenland: A serious misinterpretation of a consistent inverse association of statin use with glioma across 3 case–control studies
- Author
-
Seliger, Corinna, primary, Meier, Christoph R., additional, Becker, Claudia, additional, Jick, Susan S., additional, Bogdahn, Ulrich, additional, Hau, Peter, additional, and Leitzmann, Michael F., additional
- Published
- 2016
- Full Text
- View/download PDF
293. Metabolic syndrome in relation to risk of meningioma
- Author
-
Seliger, Corinna, primary, Meier, Christoph R., additional, Becker, Claudia, additional, Jick, Susan S., additional, Proescholdt, Martin, additional, Bogdahn, Ulrich, additional, Hau, Peter, additional, and Leitzmann, Michael F., additional
- Published
- 2016
- Full Text
- View/download PDF
294. Perspective: NutriGrade: A Scoring System to Assess and Judge the Meta-Evidence of Randomized Controlled Trials and Cohort Studies in Nutrition Research
- Author
-
Schwingshackl, Lukas, primary, Knüppel, Sven, additional, Schwedhelm, Carolina, additional, Hoffmann, Georg, additional, Missbach, Benjamin, additional, Stelmach-Mardas, Marta, additional, Dietrich, Stefan, additional, Eichelmann, Fabian, additional, Kontopanteils, Evangelos, additional, Iqbal, Khalid, additional, Aleksandrova, Krasimira, additional, Lorkowski, Stefan, additional, Leitzmann, Michael F, additional, Kroke, Anja, additional, and Boeing, Heiner, additional
- Published
- 2016
- Full Text
- View/download PDF
295. Body mass index trajectories across adulthood and smoking in relation to prostate cancer risks: the NIH-AARP Diet and Health Study.
- Author
-
Kelly, Scott P, Lennon, Hannah, Sperrin, Matthew, Matthews, Charles, Freedman, Neal D, Albanes, Demetrius, Leitzmann, Michael F, Renehan, Andrew G, and Cook, Michael B
- Subjects
BODY mass index ,PROSTATE cancer ,ADULTS ,DIET ,OBESITY complications ,LONGITUDINAL method ,OBESITY ,PROSTATE tumors ,SMOKING ,WEIGHT gain ,DISEASE incidence ,PROPORTIONAL hazards models ,DISEASE progression - Abstract
Background: Previously we showed that adulthood body mass index (BMI) trajectories that result in obesity were associated with elevated risks of fatal prostate cancer (PCA). To further explore this relationship, we conducted a study within the NIH-AARP Diet and Health Study.Methods: Among 153 730 eligible men enrolled in the NIH-AARP cohort from 1995 to 1996 (median follow-up = 15.1 years), we identified 630 fatal PCA cases and 16 896 incident cases. BMI was assessed for ages 18, 35 and 50 and at study entry, enabling examination of latent class-identified BMI trajectories. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression.Results: BMI at study entry (mean age = 63, HR = 1.12; 95% CI = 1.01, 1.24, per 5-unit increase) and maximum BMI during adulthood (HR = 1.12; 95% CI = 1.02, 1.24, per 5-unit increase) shared modest associations with increased risk of fatal PCA. Smoking status likely modified the relationship between BMI trajectories and fatal PCA (Pinteraction = 0.035 via change-in-estimate variable section, P = 0.065 via full a priori model). Among never-smokers, BMI trajectory of normal weight to obesity was associated with increased risk of fatal disease (HR = 2.37; 95% CI = 1.38, 4.09), compared with the maintained normal weight trajectory, whereas there was no association among former or current-smokers. Total and non-aggressive PCA exhibited modest inverse associations with BMI at all ages, whereas no association was observed for aggressive PCA.Conclusions: Increased BMI was positively associated with fatal PCA, especially among never-smokers. Future studies that examine PCA survival will provide additional insight as to whether these associations are the result of biology or confounding. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
296. Use of metformin and survival of patients with high‐grade glioma.
- Author
-
Seliger, Corinna, Luber, Christian, Gerken, Michael, Schaertl, Julia, Proescholdt, Martin, Riemenschneider, Markus J., Meier, Christoph R., Bogdahn, Ulrich, Leitzmann, Michael F., Klinkhammer‐Schalke, Monika, and Hau, Peter
- Abstract
High‐grade glioma (HGG) is associated with poor prognosis. Drug repurposing evolves as new modality to improve standard therapy. The antidiabetic drug metformin has been found to inhibit glioma cell growth in vitro and in vivo. The aim of the present retrospective cohort study was to evaluate the survival of patients with HGG with or without treatment with metformin, based on a large cohort of a cancer registry. The analysis included 1,093 patients with HGG diagnosed between 1998 and 2013 from the population‐based clinical cancer registry Regensburg (Germany), which covers 2.1 Mio inhabitants and 98% of all cancer diagnoses. We performed multivariable adjusted Cox‐regression analyses. Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) for overall survival (OS) and progression‐free survival (PFS) of patients with HGG with or without treatment with metformin were obtained. Use of metformin was associated with a significantly better overall and progression‐free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11–0.81, HR for PFS = 0.29; 95% CI = 0.11–0.78), while there were no significant relations with OS (HR = 0.83; 95% CI = 0.57–1.20) or PFS (HR = 0.85; 95% CI = 0.59–1.22) in patients with WHO grade IV glioma. In conclusion, use of metformin is associated with better overall and progression‐free survival of patients with WHO grade III. Possible underlying mechanisms include the higher prevalence of IDH mutations in WHO grade III glioma, which might sensitize to the metabolic drug metformin. What's new? The oral diabetes drug metformin seems to boost survival of high grade glioma (HGG). In this study, the authors examined metformin use in a cohort of over 1,000 HGG patients. Patients with WHO grade III glioma had better survival if they were taking metformin, while no improvement in outcomes was associated with other diabetes medications, including sulfonylureas or insulin. No benefit was observed in patients with WHO grade IV cancers. The authors propose that the survival benefit may be linked to IDH mutations, which often occur in stage III but not stage IV gliomas. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
297. Physical Activity and Risk of Colon Cancer in Diabetic and Nondiabetic US Adults
- Author
-
Schmid, Daniela, Behrens, Gundula, Matthews, Charles E., and Leitzmann, Michael F.
- Abstract
To determine whether moderate to vigorous physical activity is associated with a decreased risk of colon cancer in diabetic patients.
- Published
- 2024
- Full Text
- View/download PDF
298. Author Correction: Suicide risk and mortality among patients with cancer
- Author
-
Heinrich, Michael, Hofmann, Luisa, Baurecht, Hansjörg, Kreuzer, Peter M., Knüttel, Helge, Leitzmann, Michael F., and Seliger, Corinna
- Published
- 2023
- Full Text
- View/download PDF
299. Does smoking influence the physical activity and lung cancer relation? A systematic review and meta-analysis
- Author
-
Schmid, Daniela, primary, Ricci, Cristian, additional, Behrens, Gundula, additional, and Leitzmann, Michael F., additional
- Published
- 2016
- Full Text
- View/download PDF
300. Replacing Sedentary Time with Physical Activity in Relation to Mortality
- Author
-
SCHMID, DANIELA, primary, RICCI, CRISTIAN, additional, BAUMEISTER, SEBASTIAN E., additional, and LEITZMANN, MICHAEL F., additional
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.