251. Enzymes involved in the repair of damaged DNA
- Author
-
Lawrence Grossman
- Subjects
DNA Replication ,Exonucleases ,Guanine ,Chemical Phenomena ,Transcription, Genetic ,Ultraviolet Rays ,Deoxyribonucleotides ,Biophysics ,Pyrimidine dimer ,DNA-Directed DNA Polymerase ,Biochemistry ,Methylation ,AP endonuclease ,DNA Glycosylases ,Substrate Specificity ,Ribonucleotide Reductases ,Postreplication repair ,DNA-(Apurinic or Apyrimidinic Site) Lyase ,Escherichia coli ,Animals ,Humans ,Uracil-DNA Glycosidase ,Molecular Biology ,N-Glycosyl Hydrolases ,chemistry.chemical_classification ,DNA ligase ,Base Composition ,Deoxyribonucleases ,biology ,Adenine ,Escherichia coli Proteins ,Base excision repair ,DNA ,Endonucleases ,Deoxyribonuclease IV (Phage T4-Induced) ,Chemistry ,chemistry ,DNA glycosylase ,Pyrimidine Dimers ,Mutation ,Nucleic acid ,biology.protein ,DNA Transposable Elements ,Nucleotide excision repair - Abstract
The progress that has been made in our understanding of the enzymatic mechanisms by which modified nucleotides in DNA are recognized and repaired is due, in part, to the developments that have been made in photobiology and photochemistry. It was these areas of activity that led to the identification of the primary ultraviolet irradiation photoproducts formed in nucleic acids. The initial discovery of pyrimidine cyclobutane dimers (1,2) led to an understanding of their chemical properties which allowed identification of such products in DNA irradiated either in vivo or in vitro. As a consequence of this acquired technology, the fate of these photochemical products during repair could be studied in vivo and in vitro.
- Published
- 1981