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253. Eschar-associated spotted fever rickettsiosis, Bahia, Brazil

Author

Silva, Nanci, Eremeeva, Marina E., Rozental, Tatiana, Ribeiro, Guilherme S., Paddock, Christopher D., Ramos, Eduardo Antonio G., Favacho, Alexsandra R.M., Reis, Mitermayer G., Dasch, Gregory A., de Lemos, Elba R.S., and Ko, Albert I.

Subjects
Bahia, Brazil -- Health aspects, Tick-borne diseases -- Diagnosis -- Care and treatment -- Demographic aspects -- Research -- Health aspects, Disease transmission -- Research -- Diagnosis -- Care and treatment -- Health aspects, Rickettsial diseases -- Diagnosis -- Care and treatment -- Demographic aspects -- Research -- Health aspects, Health
Abstract

Brazilian spotted fever (BSF), caused by Rickettsia rickettsii, was at one time considered the only tick-borne rickettsial disease in Brazil (1). Its transmission in 5 southern states is primarily associated [...]

Published
2011
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261. Angiostrongylus cantonensis in urban populations of terrestrial gastropods and rats in an impoverished region of Brazil

Author

Souza, Fábio N., primary, Aguiar Santos, Maísa, additional, Almeida Alves, Daniele, additional, Cecília Vieira de Melo, Leyva, additional, Jessé Gonçalves da Mota, Dan, additional, Cristina Pertile, Arsinoê, additional, Gava, Ricardo, additional, Luiz Silva Pinto, Pedro, additional, Eyre, Max T., additional, Graco Zeppelini, Caio, additional, Reis, Mitermayer G., additional, Ko, Albert I., additional, Begon, Mike, additional, Bahiense, Thiago C., additional, Costa, Federico, additional, and Carvalho-Pereira, Ticiana, additional

Published
2021
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262. Knowledge, Attitude, and Practices regarding Leptospirosis among Visitors to a Recreational Forest in Malaysia

Author

Shafie, Nur Juliani, primary, Abdul Halim, Najma Syahmin, additional, Nor Zalipah, Mohamed, additional, Mohd Amin, Nur Amalin Zahirah, additional, Syed Esa, Sharifah Masit’ah, additional, Md-Nor, Shukor, additional, Casanovas-Massana, Arnau, additional, Ko, Albert I., additional, Palma, Fabiana, additional, Neves Souza, Fabio, additional, and Costa, Federico, additional

Published
2021
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263. Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study

Author

Hitchings, Matt D.T., primary, Ranzani, Otavio T., additional, Scaramuzzini Torres, Mario Sergio, additional, de Oliveira, Silvano Barbosa, additional, Almiron, Maria, additional, Said, Rodrigo, additional, Borg, Ryan, additional, Schulz, Wade L., additional, de Oliveira, Roberto Dias, additional, da Silva, Patricia Vieira, additional, de Castro, Daniel Barros, additional, de Souza Sampaio, Vanderson, additional, Cláudio de Albuquerque, Bernardino, additional, Amorim Ramos, Tatyana Costa, additional, Hauache Fraxe, Shadia Hussami, additional, da Costa, Cristiano Fernandes, additional, Naveca, Felipe Gomes, additional, Siqueira, Andre M., additional, de Araújo, Wildo Navegantes, additional, Andrews, Jason R., additional, Cummings, Derek A.T., additional, Ko, Albert I., additional, and Croda, Julio, additional

Published
2021
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264. The escalating tuberculosis crisis in central and South American prisons

Author

Walter, Katharine S, primary, Martinez, Leonardo, additional, Arakaki-Sanchez, Denise, additional, Sequera, Victor G, additional, Estigarribia Sanabria, G, additional, Cohen, Ted, additional, Ko, Albert I, additional, García-Basteiro, Alberto L, additional, Rueda, Zulma Vanessa, additional, López-Olarte, Rafael A, additional, Espinal, Marcos A, additional, Croda, Julio, additional, and Andrews, Jason R, additional

Published
2021
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265. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection

Author

McPadden, Jacob, primary, Warner, Frederick, additional, Young, H. Patrick, additional, Hurley, Nathan C., additional, Pulk, Rebecca A., additional, Singh, Avinainder, additional, Durant, Thomas J. S., additional, Gong, Guannan, additional, Desai, Nihar, additional, Haimovich, Adrian, additional, Taylor, Richard Andrew, additional, Gunel, Murat, additional, Dela Cruz, Charles S., additional, Farhadian, Shelli F., additional, Siner, Jonathan, additional, Villanueva, Merceditas, additional, Churchwell, Keith, additional, Hsiao, Allen, additional, Torre, Charles J., additional, Velazquez, Eric J., additional, Herbst, Roy S., additional, Iwasaki, Akiko, additional, Ko, Albert I., additional, Mortazavi, Bobak J., additional, Krumholz, Harlan M., additional, and Schulz, Wade L., additional

Published
2021
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266. Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums

Author

Khalil, Hussein, primary, Santana, Roberta, additional, de Oliveira, Daiana, additional, Palma, Fabiana, additional, Lustosa, Ricardo, additional, Eyre, Max T., additional, Carvalho-Pereira, Ticiana, additional, Reis, Mitermayer G., additional, Ko, Albert I., additional, Diggle, Peter J., additional, Alzate Lopez, Yeimi, additional, Begon, Mike, additional, and Costa, Federico, additional

Published
2021
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267. Accuracy of Computable Phenotyping Approaches for SARS-CoV-2 Infection and COVID-19 Hospitalizations from the Electronic Health Record

Author

Khera, Rohan, primary, Mortazavi, Bobak J., additional, Sangha, Veer, additional, Warner, Frederick, additional, Young, H. Patrick, additional, Ross, Joseph S., additional, Shah, Nilay D., additional, Theel, Elitza S., additional, Jenkinson, William G., additional, Knepper, Camille, additional, Wang, Karen, additional, Peaper, David, additional, Martinello, Richard A, additional, Brandt, Cynthia A., additional, Lin, Zhenqiu, additional, Ko, Albert I., additional, Krumholz, Harlan M., additional, Pollock, Benjamin D., additional, and Schulz, Wade L., additional

Published
2021
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268. Abstract S03-03: Cancer patients display diminished viral RNA clearance and altered T cell responses during SARS-CoV-2 infection

Author

Chiorazzi, Michael, primary, Silva, Erin, additional, Brower, Kristina, additional, Wong, Patrick, additional, Lucas, Carolina, additional, Klein, Jon, additional, Liu, Feimei, additional, Nakahata, Maura, additional, Zhao, Jun, additional, Rahman, Nur-Taz, additional, Odio, Camila, additional, Bermejo, Santos, additional, Farhadian, Shelli F., additional, Dela Cruz, Charles, additional, Casanovas-Massana, Arnau, additional, Fournier, John, additional, Muenker, Catherine, additional, Wyllie, Anne L., additional, Vogels, Chantal B.F., additional, Kalinich, Chaney C., additional, Petrone, Mary E., additional, Ott, Isabel M., additional, Watkins, Anne E., additional, Moore, Adam J., additional, Alpert, Tara, additional, Kluger, Yuval, additional, Ring, Aaron, additional, Grubaugh, Nathan D., additional, Iwasaki, Akiko, additional, Ko, Albert I., additional, and Herbst, Roy S., additional

Published
2021
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269. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis

Author

Costa, Federico, primary, Zeppelini, Caio Graco, additional, Ribeiro, Guilherme S., additional, Santos, Norlan, additional, Reis, Renato Barbosa, additional, Martins, Ridalva D., additional, Bittencourt, Deborah, additional, Santana, Carlos, additional, Brant, Jonas, additional, Reis, Mitermayer G., additional, and Ko, Albert I., additional

Published
2021
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270. SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity

Author

Vogels, Chantal B.F., primary, Watkins, Anne E., additional, Harden, Christina A., additional, Brackney, Doug E., additional, Shafer, Jared, additional, Wang, Jianhui, additional, Caraballo, César, additional, Kalinich, Chaney C., additional, Ott, Isabel M., additional, Fauver, Joseph R., additional, Kudo, Eriko, additional, Lu, Peiwen, additional, Venkataraman, Arvind, additional, Tokuyama, Maria, additional, Moore, Adam J., additional, Muenker, M. Catherine, additional, Casanovas-Massana, Arnau, additional, Fournier, John, additional, Bermejo, Santos, additional, Campbell, Melissa, additional, Datta, Rupak, additional, Nelson, Allison, additional, Dela Cruz, Charles S., additional, Ko, Albert I., additional, Iwasaki, Akiko, additional, Krumholz, Harlan M., additional, Matheus, J.D., additional, Hui, Pei, additional, Liu, Chen, additional, Farhadian, Shelli F., additional, Sikka, Robby, additional, Wyllie, Anne L., additional, Grubaugh, Nathan D., additional, Anastasio, Kelly, additional, Askenase, Michael H., additional, Batsu, Maria, additional, Bickerton, Sean, additional, Brower, Kristina, additional, Bucklin, Molly L., additional, Cahill, Staci, additional, Cao, Yiyun, additional, Courchaine, Edward, additional, DeIuliis, Giuseppe, additional, Earnest, Rebecca, additional, Geng, Bertie, additional, Goldman-Israelow, Benjamin, additional, Handoko, Ryan, additional, Khoury-Hanold, William, additional, Kim, Daniel, additional, Knaggs, Lynda, additional, Kuang, Maxine, additional, Lapidus, Sarah, additional, Lim, Joseph, additional, Linehan, Melissa, additional, Lu-Culligan, Alice, additional, Martin, Anjelica, additional, Matos, Irene, additional, McDonald, David, additional, Minasyan, Maksym, additional, Nakahata, Maura, additional, Naushad, Nida, additional, Nouws, Jessica, additional, Obaid, Abeer, additional, Odio, Camila, additional, Oh, Ji Eun, additional, Omer, Saad, additional, Park, Annsea, additional, Park, Hong-Jai, additional, Peng, Xiaohua, additional, Petrone, Mary, additional, Prophet, Sarah, additional, Rice, Tyler, additional, Rose, Kadi-Ann, additional, Sewanan, Lorenzo, additional, Sharma, Lokesh, additional, Shaw, Albert C., additional, Shepard, Denise, additional, Smolgovsky, Mikhail, additional, Sonnert, Nicole, additional, Strong, Yvette, additional, Todeasa, Codruta, additional, Valdez, Jordan, additional, Velazquez, Sofia, additional, Vijayakumar, Pavithra, additional, White, Elizabeth B., additional, and Yang, Yexin, additional

Published
2021
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271. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study

Author

Aguilar Ticona, Juan P., primary, Nery, Nivison, additional, Ladines-Lim, Joseph B., additional, Gambrah, Claudia, additional, Sacramento, Gielson, additional, de Paula Freitas, Bruno, additional, Bouzon, Joseane, additional, Oliveira-Filho, Jamary, additional, Borja, Ana, additional, Adhikarla, Haritha, additional, Montoya, Magelda, additional, Chin, Athena, additional, Wunder, Elsio A., additional, Ballalai, Verena, additional, Vieira, Carina, additional, Belfort, Rubens, additional, P. Almeida, Antonio R., additional, Reis, Mitermayer G., additional, Harris, Eva, additional, Ko, Albert I., additional, and Costa, Federico, additional

Published
2021
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272. Immunologically distinct responses occur in the CNS of COVID-19 patients

Author

Song, Eric, Chow, Ryan D, Jiang, Ruoyi, Zamecnik, Colin R., Loudermilk, Rita P, Dai, Yile, Liu, Feimei, Geng, Bertie, Chiarella, Jennifer, Israelow, Benjamin, Casanovas-Massana, Arnau, Ko, Albert I, Ring, Aaron, Kleinstein, Steven H., Spudich, Serena, Wilson, Michael R, Iwasaki, Akiko, and Farhadian, Shelli F.

Subjects
biochemical phenomena, metabolism, and nutrition, Article
Abstract

A subset of patients with COVID-19 display neurologic symptoms but it remains unknown whether SARS-CoV-2 damages the central nervous system (CNS) directly through neuroinvasion, or if neurological symptoms are due to secondary mechanisms, including immune-mediated effects. Here, we examined the immune milieu in the CNS through the analysis of cerebrospinal fluid (CSF) and in circulation through analysis of peripheral blood mononuclear cells (PBMCs) of COVID-19 patients with neurological symptoms. Single cell sequencing with paired repertoire sequencing of PBMCs and CSF cells show evidence for unique immune response to SARS-CoV-2 in the CNS. Strikingly, anti-SARS-CoV-2 antibodies are present in the CSF of all patients studied, but the antibody epitope specificity in the CSF and relative prevalence of B cell receptor sequences markedly differed when compared to those found in paired serum. Finally, using a mouse model of SARS-CoV-2 infection, we demonstrate that localized CNS immune responses occur following viral neuroinvasion, and that the CSF is a faithful surrogate for responses occurring uniquely in the CNS. These results illuminate CNS compartment-specific immune responses to SARS-CoV-2, forming the basis for informed treatment of neurological symptoms associated with COVID-19.

Published
2020

273. Longitudinal analyses reveal immunological misfiring in severe COVID-19

Author

Lucas, Carolina, Wong, Patrick, Klein, Jon, Castro, Tiago B. R., Silva, Julio, Sundaram, Maria, Ellingson, Mallory K., Mao, Tianyang, Oh, Ji Eun, Israelow, Benjamin, Takahashi, Takehiro, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Mohanty, Subhasis, Wang, Haowei, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Muenker, M. Catherine, Fournier, John B., Campbell, Melissa, Odio, Camila D., Casanovas-Massana, Arnau, Obaid, Abeer, Lu-Culligan, Alice, Nelson, Allison, Brito, Anderson, Nunez, Angela, Martin, Anjelica, Watkins, Annie, Geng, Bertie, Kalinich, Chaney, Harden, Christina, Todeasa, Codruta, Jensen, Cole, Kim, Daniel, McDonald, David, Shepard, Denise, Courchaine, Edward, White, Elizabeth B., Song, Eric, Silva, Erin, Kudo, Eriko, DeIuliis, Giuseppe, Rahming, Harold, Park, Hong-Jai, Matos, Irene, Nouws, Jessica, Valdez, Jordan, Fauver, Joseph, Lim, Joseph, Rose, Kadi-Ann, Anastasio, Kelly, Brower, Kristina, Glick, Laura, Sharma, Lokesh, Sewanan, Lorenzo, Knaggs, Lynda, Minasyan, Maksym, Batsu, Maria, Petrone, Mary, Kuang, Maxine, Nakahata, Maura, Linehan, Melissa, Askenase, Michael H., Simonov, Michael, Smolgovsky, Mikhail, Sonnert, Nicole, Naushad, Nida, Vijayakumar, Pavithra, Martinello, Rick, Datta, Rupak, Handoko, Ryan, Bermejo, Santos, Prophet, Sarah, Bickerton, Sean, Velazquez, Sofia, Alpert, Tara, Rice, Tyler, Khoury-Hanold, William, Peng, Xiaohua, Yang, Yexin, Cao, Yiyun, Strong, Yvette, Herbst, Roy, Shaw, Albert C., Medzhitov, Ruslan, Schulz, Wade L., Grubaugh, Nathan D., Dela Cruz, Charles, Farhadian, Shelli, Ko, Albert I., Omer, Saad B., and Iwasaki, Akiko

Subjects
Adult, Male, 0301 basic medicine, Chemokine, T-Lymphocytes, medicine.medical_treatment, T cell, Pneumonia, Viral, Disease, Article, Pathogenesis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cluster Analysis, Humans, Medicine, Pandemics, Aged, Aged, 80 and over, Interleukin-13, Innate immune system, Multidisciplinary, biology, business.industry, COVID-19, Immunoglobulin E, Middle Aged, Viral Load, Eosinophils, 030104 developmental biology, Cytokine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Interleukin 13, Immunology, biology.protein, Cytokines, Female, Interleukin-5, Coronavirus Infections, business
Abstract

Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)1–4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analysed immune responses in 113 patients with moderate or severe COVID-19. Immune profiling revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell number. An early elevation in cytokine levels was associated with worse disease outcomes. Following an early increase in cytokines, patients with moderate COVID-19 displayed a progressive reduction in type 1 (antiviral) and type 3 (antifungal) responses. By contrast, patients with severe COVID-19 maintained these elevated responses throughout the course of the disease. Moreover, severe COVID-19 was accompanied by an increase in multiple type 2 (anti-helminths) effectors, including interleukin-5 (IL-5), IL-13, immunoglobulin E and eosinophils. Unsupervised clustering analysis identified four immune signatures, representing growth factors (A), type-2/3 cytokines (B), mixed type-1/2/3 cytokines (C), and chemokines (D) that correlated with three distinct disease trajectories. The immune profiles of patients who recovered from moderate COVID-19 were enriched in tissue reparative growth factor signature A, whereas the profiles of those with who developed severe disease had elevated levels of all four signatures. Thus, we have identified a maladapted immune response profile associated with severe COVID-19 and poor clinical outcome, as well as early immune signatures that correlate with divergent disease trajectories.

Published
2020
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274. Supplementary Information, Figures S1 - S3, Tables S1 - S9 from Ancient mitogenomes show plateau populations from last 5200 years partially contributed to present-day Tibetans

Author

Manyu Ding, Tianyi Wang, Ko, Albert Min-Shan, Honghai Chen, Wang, Hui, Guanghui Dong, Hongliang Lu, He, Wei, Shargan Wangdue, Haibing Yuan, Yuanhong He, Linhai Cai, Zujun Chen, Guangliang Hou, Dongju Zhang, Zhaoxia Zhang, Cao, Peng, Qingyan Dai, Xiaotian Feng, Zhang, Ming, Hongru Wang, Yang, Melinda A., and Qiaomei Fu

Abstract

Supplementary Information

Published
2020
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275. Rattiness_1_supplementary.pdf from A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community

Author

Eyre, Max T., Ticiana S. A. Carvalho-Pereira, Fábio N. Souza, Khalil, Hussein, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua P., Mitermayer G. Reis, Ko, Albert I., Begon, Mike, Diggle, Peter J., Costa, Federico, and Giorgi, Emanuele

Abstract

A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance. We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease.

Published
2020
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276. ESM_README.pdf from A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community

Author

Eyre, Max T., Ticiana S. A. Carvalho-Pereira, Fábio N. Souza, Khalil, Hussein, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua P., Mitermayer G. Reis, Ko, Albert I., Begon, Mike, Diggle, Peter J., Costa, Federico, and Giorgi, Emanuele

Abstract

A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance. We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease.

Published
2020
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277. An international registry for emergent pathogens and pregnancy

Author

Alice Panchaud, Guillaume Favre, Leo Pomar, Manon Vouga, Karoline Aebi-Popp, David Baud, Tallarek Ann-Christin, Strizek Brigitte, Hecher Kurt, Böckenhoff Paul, Schrey-Petersen Susanne, Mullins Edward, Bromley Rebecca, Whitehead Clare, Rolnik Daniel, Deprest Jan, Richter Jute, Gomes Luz Adriana, Bohrer Betania, Carvalho Ribeiro-do-Valle Carolina, Garanhani Surita Fernanda, Schuler-Faccini Lavinia, Osorio Wender Maria Celeste, Da Rocha Oppermann Maria Lucia, Moreira de sa Renato Augusto, Quintana Silvana, Sjaus Ana, Rahman Arifa, Hamel-Thibault Audrey, Nash Christopher, Kakkar Fatima, Berger Howard, Boucoiran Isabelle, Pasquier Jean-Charles, Snelgrove John, Zipursky Jonathan, Lacroix Meagan, Whittle Wendy, Fuenzalida Javiera, Carvajal Jorge, Guerra Canales Manuel, Hernandez Olivia, Yin Mingzhu, Chen Xiang, Qi Xiaolong, Sanín Blair José Enrique, Gonzalez Ricardo, Cano Aguilar Africa, Rodriguez Vicente Agueda, Tubau Navarra Albert, Puertas Prieto Alberto, Cano Garcia Alejandra Maria, Carrascal Cumplido Ana, Villalba Yarza Ana, Filloy Lavia Ana Cristina, Fernandez Alonso Ana Maria, Sanchez Vegazo Garcia Angeles, Goncé Anna, Ruano Garcia Antonio, Sanchez Munoz Antonio, Marcos Puig Beatriz, Munoz Abellana Begona, Garrido Luque Belen, Fernandez Fernandez Camino, Larranaga Azcarate Carlos, Baena Luque Carmen, Orizales Lago Carmen Maria, Alvarez Colomo Cristina, Lesmes Heredia Cristina, Ruiz Aguilar Cristina, Ferriols Perez Elena, Pascual Salvador Elena, Carmona Sanchez Encarnacion, Alvarez Silvares Esther, Canedo Carballeira Esther Maria, Moran Antolin Eva, Muelas Parraga Eva Maria, Oviedo Perez Eva Maria, Gonzalez Carvajal Francisco Jesus, Agudo Iène, Ocerin Bengoa Iratxe, Gastaca Abasolo Irene, Cabello de Alba Fernandez Isabel, Alvarez Javier, Duro Gomez Jorge, Atxotegi Jose, Navarrina Martinez José, Ruiz Aragon José, Sainz Bueno José Antonio, Adanez Garcia Jose Manuel, Broullon Molanes José Roman, Wizner de Alva Juan Carlos, Forcen Acebal Laura, Gonzalez Rodriguez Laura, Aceituno Velasco Longinos, Cerrillos Gonzalez Lucas, Trigo Lucas, Diaz Meca Lucia, Parada Millan M Carmen, Molina Oller Magdalena, Dominguez Gonzalez Manuel, Munoz Chapuli Gutierrez Mar, Caridad Ortiz Herrera Maria, Nieves Quesada Fernandez Maria, Suarez Arana Maria, Teulon Gonzalez Maria, Zafra Bailera Maria, Duenas Carazo Maria Begona, Gonzalez Macias Maria Carmen, Pilar Guadix Martin Maria del, Barbancho Lopez Maria del Carmen, Medina Mallen Maria del Carmen, Pardo Pumar Maria Isabel, Gimeno Gimeno Maria Joaquina, Nunez Valera Maria José, Pelegay Escartin Maria José, Camacho Caro Marta, Garcia Sanchez Marta, Meca Casbas Marta Ruth, Fraca Padilla Mercedes, Ramirez Gomez Mercedes, Catalina Coello Monica, Cruz Lemini Monica, Perez Perez Noelia, Nieto Velasco Olga, Alomar Mateu Onofre, Martinez Perez Oscar, Vaquerizo Ruiz Oscar, Barrio Fernández Pablo Guillermo del, Monteliu Gonzalez Pilar, Prats Rodriguez Pilar, Vivaracho Terrer Porfirio, Gonzales Seoane Raquel, Jimenez Velazquez Raquel, Alvarez Fernandez Rebeca, Lopez Perez Rocio, Ostos Serna Rosa Maria, Redondo Aguilar Rosario, Bernardo Vega Rut, Cano Sandra, Mateos Lopez Silvia, Fernandez Garcia Susana, Soldevilla Perez Susana, Manrique Gomez Tania, Munoz Carmona Vitor, Ko Albert I, Johnson Anthony, Nielsen Saines Karin, Cambou Mary, Grechukhina Olga, Neupane Sahara, Reddy Uma, Shah Zubin, Breton Bénédicte, Garabedian Charles, Bertholdt Charline, Poncelet Christophe, Subtil Damien, Musso Didier, Henry Estelle, Plantefeve Gaetan, Ducarme Guillaume, Pelerin Helene, Dimet Jerome, Cottin Judith, Stiremann Julien, Lambert Véronique, Hcini Najeh, Salomon Laurent, Sentilhes Loïc, Giral Marylene, Mottet Nicolas, Morel Olivier, Rozenberg Patrick, Lucie Sedille, Quibel Thibaud, Karagianni Vasiliki, Equy Véronique, Ville Yves, Carles Gabriel, Ruehl Ina, Cleary Brian, Malone Fergal, Higgins Mary, Geary Michael, Hadar Eran, Malinger Gustavo, Sela Hen, Krajden Haratz Karina, Maymon Ron, Yogev Yariv, De Luca Carmen, De Santis Marco, Rosso Telefono, Atallah David, Boguziene Emilija, Germes Pina Fernando, Van den Akker Thomas, Gil-Guevara Enrique, Marchena Jeannette, Ventura Walter, Pereira Alcides, Ayres de Campos Diogo, Charepe Nadia, Viana Pinto Pedro, Ntasumbumuyange Diomede, Rulisa Stephen, Panchaud Alice, Radan Anda-Petronela, Papadia Andrea, Bloch Andrea, Feki Anis, Muller Brochut Anne-Claude, Toussaint Arnaud, Eggel-Hort Béatrice, Martinez de Tejada Begoña, Frey Tirri Brigitte, Weber Brigitte, Blume Carolin, Monod Cécile, Kahlert Christian, Voekt Cora, Surbek Daniel, Baud David, Bassler Dirk, Mueller Doris, Prentl Elke Barbara, Gerber Eva, Rothe Friederike, Eric Giannoni, Favre Guillaume, Hoesli Irene, Mathis Jérôme, Lepigeon Karine, Aebi-Popp Karoline, Pomar Leo, Schäffer Leonhard, Raio Luigi, Vouga Manon, Huesler Charles Margaret, Rossier Marie-Claude, Hodel Markus, Kaufmann Martin, Gavillet Mathilde, Boulvain Michel, Todesco Bernasconi Monya, Bickle Myriam, Ochsenbein Kölble Nicole, Jarrah Omar, Kanellos Panagiotis, Brasier Lutz Pascale, Capoccia Brugger Romina, Heldstab Sandra, Heldstab Sandra Andrea, Rouiller Cornu Sylvie, Fischer Tina, Winterfeld Ursula, Lambelet Valentine, Rieder Wawrzyniec, Greub Gilbert, Gengler Carole, Patel Rena C, Huespe Miguel Angel, Nieto-Calvache Albaro José, COVI-Preg group, Ann-Christin, T., Brigitte, S., Kurt, H., Paul, B., Susanne, S.P., Edward, M., Rebecca, B., Clare, W., Daniel, R., Jan, D., Jute, R., Adriana, G.L., Betania, B., Carolina, C.R., Fernanda, G.S., Lavinia, S.F., Maria Celeste, O.W., Maria Lucia, DRO, Renato Augusto, M.S., Silvana, Q., Ana, S., Arifa, R., Audrey, H.T., Christopher, N., Fatima, K., Howard, B., Isabelle, B., Jean-Charles, P., John, S., Jonathan, Z., Meagan, L., Wendy, W., Javiera, F., Jorge, C., Manuel, G.C., Olivia, H., Mingzhu, Y., Xiang, C., Xiaolong, Q., José Enrique, S.B., Ricardo, G., Africa, C.A., Agueda, R.V., Albert, T.N., Alberto, P.P., Alejandra Maria, C.G., Ana, C.C., Ana, V.Y., Ana Cristina, F.L., Ana Maria, F.A., Angeles, SVG, Anna, G., Antonio, R.G., Antonio, S.M., Beatriz, M.P., Begona, M.A., Belen, G.L., Camino, F.F., Carlos, L.A., Carmen, B.L., Carmen Maria, O.L., Cristina, A.C., Cristina, L.H., Cristina, R.A., Elena, F.P., Elena, P.S., Encarnacion, C.S., Esther, A.S., Esther Maria, C.C., Eva, M.A., Eva Maria, M.P., Eva Maria, O.P., Francisco Jesus, G.C., Iène, A., Iratxe, O.B., Irene, G.A., Isabel, CAF, Javier, A., Jorge, D.G., Jose, A., José, N.M., José, R.A., José Antonio, S.B., Jose Manuel, A.G., José Roman, B.M., Juan Carlos, W.A., Laura, F.A., Laura, G.R., Longinos, A.V., Lucas, C.G., Lucas, T., Lucia, D.M., M Carmen, P.M., Magdalena, M.O., Manuel, D.G., Mar, MCG, Maria, COH, Maria, NQF, Maria, S.A., Maria, T.G., Maria, Z.B., Maria Begona, D.C., Maria Carmen, G.M., Maria Del, PGM, Maria Del Carmen, B.L., Maria Del Carmen, M.M., Maria Isabel, P.P., Maria Joaquina, G.G., Maria José, N.V., Maria José, P.E., Marta, C.C., Marta, G.S., Marta Ruth, M.C., Mercedes, F.P., Mercedes, R.G., Monica, C.C., Monica, C.L., Noelia, P.P., Olga, N.V., Onofre, A.M., Oscar, M.P., Oscar, V.R., Pablo Guillermo Del, B.F., Pilar, M.G., Pilar, P.R., Porfirio, V.T., Raquel, G.S., Raquel, J.V., Rebeca, A.F., Rocio, L.P., Rosa Maria, O.S., Rosario, R.A., Rut, B.V., Sandra, C., Silvia, M.L., Susana, F.G., Susana, S.P., Tania, M.G., Vitor, M.C., Albert I, K., Anthony, J., Karin, N.S., Mary, C., Olga, G., Sahara, N., Uma, R., Zubin, S., Bénédicte, B., Charles, G., Charline, B., Christophe, P., Damien, S., Didier, M., Estelle, H., Gaetan, P., Guillaume, D., Helene, P., Jerome, D., Judith, C., Julien, S., Véronique, L., Najeh, H., Laurent, S., Loïc, S., Marylene, G., Nicolas, M., Olivier, M., Patrick, R., Sedille, L., Thibaud, Q., Vasiliki, K., Véronique, E., Yves, V., Gabriel, C., Ina, R., Brian, C., Fergal, M., Mary, H., Michael, G., Eran, H., Gustavo, M., Hen, S., Karina, K.H., Ron, M., Yariv, Y., Carmen, L., Marco, S., Telefono, R., David, A., Emilija, B., Fernando, G.P., Thomas, VDA, Enrique, G.G., Jeannette, M., Walter, V., Alcides, P., Diogo, A.C., Nadia, C., Pedro, V.P., Diomede, N., Stephen, R., Alice, P., Anda-Petronela, R., Andrea, P., Andrea, B., Anis, F., Anne-Claude, M.B., Arnaud, T., Béatrice, E.H., Begoña, M.T., Brigitte, F.T., Brigitte, W., Carolin, B., Cécile, M., Christian, K., Cora, V., Daniel, S., David, B., Dirk, B., Doris, M., Elke Barbara, P., Eva, G., Friederike, R., Giannoni, E., Guillaume, F., Irene, H., Jérôme, M., Karine, L., Karoline, A.P., Leo, P., Leonhard, S., Luigi, R., Manon, V., Margaret, H.C., Marie-Claude, R., Markus, H., Martin, K., Mathilde, G., Michel, B., Monya, T.B., Myriam, B., Nicole, O.K., Omar, J., Panagiotis, K., Pascale, B.L., Romina, C.B., Sandra, H., Sandra Andrea, H., Sylvie, R.C., Tina, F., Ursula, W., Valentine, L., Wawrzyniec, R., Gilbert, G., Carole, G., Rena C, P., Miguel Angel, H., and Albaro José, N.C.

Subjects
Diagnostic Screening Programs, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Severe Acute Respiratory Syndrome, Communicable Diseases, Emerging, Risk Assessment, Betacoronavirus, Fetus, Pregnancy, Risk Factors, Pandemic, medicine, Humans, Registries, 610 Medicine & health, Intensive care medicine, Pandemics, Zika Virus Infection, Viral Epidemiology, business.industry, Pregnancy Outcome, Betacoronavirus/growth & development, Betacoronavirus/immunology, Communicable Diseases, Emerging/epidemiology, Communicable Diseases, Emerging/prevention & control, Coronavirus Infections/epidemiology, Diagnostic Screening Programs/standards, Female, Interdisciplinary Placement/methods, Pneumonia, Viral/epidemiology, Pregnancy Outcome/epidemiology, Severe Acute Respiratory Syndrome/epidemiology, Zika Virus/immunology, Zika Virus Infection/epidemiology, COVID-19, Zika Virus, General Medicine, medicine.disease, Interdisciplinary Placement, sars-cov-2, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Coronavirus Infections, business
Published
2020

278. codebook.pdf from A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community

Author

Eyre, Max T., Ticiana S. A. Carvalho-Pereira, Fábio N. Souza, Khalil, Hussein, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua P., Mitermayer G. Reis, Ko, Albert I., Begon, Mike, Diggle, Peter J., Costa, Federico, and Giorgi, Emanuele

Abstract

A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance. We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease.

Published
2020
Full Text
View/download PDF

279. Osmotic regulation of expression of two extracellular matrix-binding proteins and a haemolysin of Leptospira interrogans: differential effects on LigA and Sph2 extracellular release

Author

Matsunaga, James, Medeiros, Marco A., Sanchez, Yolanda, Werneid, Kristian F., and Ko, Albert I.

Subjects
Gram-negative bacteria -- Physiological aspects, Gram-negative bacteria -- Properties, Osmosis -- Research, Extracellular matrix -- Properties, Binding proteins -- Properties, Biological sciences
Abstract

The life cycle of the pathogen Leptospira interrogans involves stages outside and inside the host. Entry of L. interrogans from moist environments into the host is likely to be accompanied by the induction of genes encoding virulence determinants and the concomitant repression of genes encoding products required for survival outside of the host. The expression of the adhesin LigA, the haemolysin Sph2 (Lk73.5) and the outer-membrane lipoprotein LipL36 of pathogenic Leptospira species have been reported to be regulated by mammalian host signals. A previous study demonstrated that raising the osmolarity of the leptospiral growth medium to physiological levels encountered in the host by addition of various salts enhanced the levels of cell-associated LigA and LigB and extracellular LigA. In this study, we systematically examined the effects of osmotic upshift with ionic and non-ionic solutes on expression of the known mammalian host-regulated leptospiral genes. The levels of cell-associated LigA, LigB and Sph2 increased at physiological osmolarity, whereas LipL36 levels decreased, corresponding to changes in specific transcript levels. These changes in expression occurred irrespective of whether sodium chloride or sucrose was used as the solute. The increase of cellular LigA, LigB and Sph2 protein levels occurred within hours of adding sodium chloride. Extracellular Sph2 levels increased when either sodium chloride or sucrose was added to achieve physiological osmolarity. In contrast, enhanced levels of extracellular LigA were observed only with an increase in ionic strength. These results indicate that the mechanisms for release of LigA and Sph2 differ during host infection. Thus, osmolarity not only affects leptospiral gene expression by affecting transcript levels of putative virulence determinants but also affects the release of such proteins into the surroundings.

Published
2007

280. Slum Health: Arresting COVID-19 and Improving Well-Being in Urban Informal Settlements.

Author

Corburn, Jason, Corburn, Jason, Vlahov, David, Mberu, Blessing, Riley, Lee, Caiaffa, Waleska Teixeira, Rashid, Sabina Faiz, Ko, Albert, Patel, Sheela, Jukur, Smurti, Martínez-Herrera, Eliana, Jayasinghe, Saroj, Agarwal, Siddharth, Nguendo-Yongsi, Blaise, Weru, Jane, Ouma, Smith, Edmundo, Katia, Oni, Tolu, Ayad, Hany, Corburn, Jason, Corburn, Jason, Vlahov, David, Mberu, Blessing, Riley, Lee, Caiaffa, Waleska Teixeira, Rashid, Sabina Faiz, Ko, Albert, Patel, Sheela, Jukur, Smurti, Martínez-Herrera, Eliana, Jayasinghe, Saroj, Agarwal, Siddharth, Nguendo-Yongsi, Blaise, Weru, Jane, Ouma, Smith, Edmundo, Katia, Oni, Tolu, and Ayad, Hany

Abstract

The informal settlements of the Global South are the least prepared for the pandemic of COVID-19 since basic needs such as water, toilets, sewers, drainage, waste collection, and secure and adequate housing are already in short supply or non-existent. Further, space constraints, violence, and overcrowding in slums make physical distancing and self-quarantine impractical, and the rapid spread of an infection highly likely. Residents of informal settlements are also economically vulnerable during any COVID-19 responses. Any responses to COVID-19 that do not recognize these realities will further jeopardize the survival of large segments of the urban population globally. Most top-down strategies to arrest an infectious disease will likely ignore the often-robust social groups and knowledge that already exist in many slums. Here, we offer a set of practice and policy suggestions that aim to (1) dampen the spread of COVID-19 based on the latest available science, (2) improve the likelihood of medical care for the urban poor whether or not they get infected, and (3) provide economic, social, and physical improvements and protections to the urban poor, including migrants, slum communities, and their residents, that can improve their long-term well-being. Immediate measures to protect residents of urban informal settlements, the homeless, those living in precarious settlements, and the entire population from COVID-19 include the following: (1) institute informal settlements/slum emergency planning committees in every urban informal settlement; (2) apply an immediate moratorium on evictions; (3) provide an immediate guarantee of payments to the poor; (4) immediately train and deploy community health workers; (5) immediately meet Sphere Humanitarian standards for water, sanitation, and hygiene; (6) provide immediate food assistance; (7) develop and implement a solid waste collection strategy; and (8) implement immediately a plan for mobility and health care. Lessons have been

Published
2020

281. A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs:a case study of rattiness in a low-income urban Brazilian community

Author

Eyre, Max, Carvalho-Pereira, Ticiana, Souza, Fábio N., Hussein, Khalil, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua, Reis, Mitermayer G., Ko, Albert I., Begon, Mike, Diggle, Peter, Costa, Federico, Giorgi, Emanuele, Eyre, Max, Carvalho-Pereira, Ticiana, Souza, Fábio N., Hussein, Khalil, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua, Reis, Mitermayer G., Ko, Albert I., Begon, Mike, Diggle, Peter, Costa, Federico, and Giorgi, Emanuele

Abstract

A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is a likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance. We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease.

Published
2020

282. A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs : a case study of rattiness in a low-income urban Brazilian community

Author

Eyre, Max, Carvalho-Pereira, Ticiana, Souza, Fábio N., Hussein, Khalil, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua, Reis, Mitermayer G., Ko, Albert I., Begon, Mike, Diggle, Peter, Costa, Federico, Giorgi, Emanuele, Eyre, Max, Carvalho-Pereira, Ticiana, Souza, Fábio N., Hussein, Khalil, Hacker, Kathryn P., Serrano, Soledad, Taylor, Joshua, Reis, Mitermayer G., Ko, Albert I., Begon, Mike, Diggle, Peter, Costa, Federico, and Giorgi, Emanuele

Abstract

A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is a likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance. We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease.

Published
2020

287. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus

Author

Wunder, Elsio A, primary, Adhikarla, Haritha, additional, Hamond, Camila, additional, Owers Bonner, Katharine A, additional, Liang, Li, additional, Rodrigues, Camila B, additional, Bisht, Vimla, additional, Nally, Jarlath E, additional, Alt, David P, additional, Reis, Mitermayer G, additional, Diggle, Peter J, additional, Felgner, Philip L, additional, and Ko, Albert, additional

Published
2021
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288. Spatial and Simultaneous Seroprevalence of Anti-Leptospira Antibodies in Owners and Their Domiciled Dogs in a Major City of Southern Brazil

Author

Benitez, Aline do Nascimento, primary, Monica, Thais Cabral, additional, Miura, Ana Carolina, additional, Romanelli, Micheline Sahyun, additional, Giordano, Lucienne Garcia Pretto, additional, Freire, Roberta Lemos, additional, Mitsuka-Breganó, Regina, additional, Martins, Camila Marinelli, additional, Biondo, Alexander Welker, additional, Serrano, Isabela Machado, additional, Lopes, Thiago Henrique Carneiro Rios, additional, Reis, Renato Barbosa, additional, Gomes, Jancarlo Ferreira, additional, Costa, Federico, additional, Wunder, Elsio, additional, Ko, Albert Icksang, additional, and Navarro, Italmar Teodorico, additional

Published
2021
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289. Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents

Author

Aguilar Ticona, Juan P, primary, Baig, Huma, additional, Nery, Nivison, additional, Doss-Gollin, Simon, additional, Sacramento, Gielson A, additional, Adhikarla, Haritha, additional, Muenker, M Catherine, additional, Wunder, Elsio A, additional, Nascimento, Eduardo J M, additional, Marques, Ernesto T A, additional, Reis, Mitermayer G, additional, Ko, Albert I, additional, and Costa, Federico, additional

Published
2021
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290. Long-term follow-up of branch-duct intraductal papillary mucinous neoplasms with No change in first 5 Years of diagnosis

Author

Lee, Brian S., primary, Nguyen, Andrew K., additional, Tekeste, Timnit F., additional, Chang, Karen, additional, Girgis, Agathon, additional, Adeyemo, Mopelola, additional, Hanna, Maryam S., additional, Yao, Janis F., additional, Kwok, Karl K., additional, Giap, Andrew Q., additional, Hunt, Gordon C., additional, Chaya, Charles T., additional, Kao, Kevin T., additional, Attam, Rajeev, additional, Ko, Albert, additional, Pio, Jose R., additional, Tovar, Stephanie, additional, and Lim, Brian S., additional

Published
2021
Full Text
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292. Author response: A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus

Author

Wunder, Elsio A, primary, Adhikarla, Haritha, additional, Hamond, Camila, additional, Owers Bonner, Katharine A, additional, Liang, Li, additional, Rodrigues, Camila B, additional, Bisht, Vimla, additional, Nally, Jarlath E, additional, Alt, David P, additional, Reis, Mitermayer G, additional, Diggle, Peter J, additional, Felgner, Philip L, additional, and Ko, Albert, additional

Published
2020
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294. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate among the Non-Congregant Population in Connecticut

Author

Mahajan, Shiwani, primary, Caraballo, César, additional, Li, Shu-Xia, additional, Dong, Claire, additional, Chen, Lian, additional, Huston, Sara K., additional, Srinivasan, Rajesh, additional, Redlich, Carrie A., additional, Ko, Albert I., additional, Faust, Jeremy S., additional, Forman, Howard P., additional, and Krumholz, Harlan M., additional

Published
2020
Full Text
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295. Contributors

Author

Abrams, Charles S., primary, Accurso, Frank J., additional, Afdhal, Nezam H., additional, Akin, Cem, additional, Aksamit, Allen J., additional, Al-Awqati, Qais, additional, Allos, Ban Mishu, additional, Altshuler, David, additional, Aminoff, Michael J., additional, Anderson, Jeffrey L., additional, Anderson, Karl E., additional, Anderson, Larry J., additional, Antman, Karen H., additional, Antony, Aśok C., additional, Appel, Gerald B., additional, Appelbaum, Frederick R., additional, Arend, William P., additional, Arguin, Paul, additional, Armitage, James O., additional, Armstrong, Cheryl A., additional, Arnaout, M. Amin, additional, Arnold, Robert, additional, Atkins, David, additional, Atkinson, William L., additional, Ausiello, Dennis, additional, Bacon, Bruce R., additional, Bagby, Grover C., additional, Bain, Barbara J., additional, Bajorin, Dean F., additional, Ballow, Mark, additional, Baloh, Robert W., additional, Barasch, Jonathan, additional, Barbano, Richard L., additional, Baron, Murray G., additional, Barrett-Connor, Elizabeth, additional, Barry, Michael J., additional, Barshop, Bruce A., additional, Bartlett, John G., additional, Barton, Mary, additional, Basner, Robert C., additional, Baum, Stephen G., additional, Bausch, Daniel G., additional, Bayer, Arnold S., additional, Bazari, Hasan, additional, Beigel, John H., additional, Beller, George A., additional, Bennett, Robert M., additional, Berger, Joseph R., additional, Berk, Paul, additional, Berliner, Nancy, additional, Bernat, James L., additional, Bierman, Philip J., additional, Bistrian, Bruce R., additional, Biundo, Joseph J., additional, Blanke, Charles D., additional, Blankson, Joel N., additional, Blaser, Martin J., additional, Blattner, William A., additional, Bleck, Thomas P., additional, Boden, William E., additional, Boland, C. Richard, additional, Bolognia, Jean, additional, Bonomo, Robert, additional, Borish, Larry, additional, Bosque, Patrick J., additional, Brand, Randall, additional, Brook, Itzhak, additional, Brunetti, Enrico, additional, Buchner, David M., additional, Buffet, Pierre A., additional, Bunn, H. Franklin, additional, Calabresi, Peter A., additional, Calfee, David P., additional, Calkins, Hugh, additional, Cameron, Douglas, additional, Camilleri, Michael, additional, Cannon, Grant W., additional, Cappellini, Maria Domenica, additional, Carabello, Blase A., additional, Carvalho, Edgar M., additional, Castellanos, Agustin, additional, Chalasani, Naga P., additional, Chambers, Henry, additional, Charlson, Mary, additional, Cheshire, William P., additional, Chinnery, Patrick F., additional, Christiani, David C., additional, Clemmons, David R., additional, Cohen, Jeffrey, additional, Cohen, Myron S., additional, Cohen, Steven P., additional, Cohn, Steven L., additional, Colebunders, Robert, additional, Connors, Joseph M., additional, Cook, Deborah J., additional, Corey, C. Ralph, additional, Cowan, Kenneth H., additional, Craig, William A., additional, Croft, Simon L., additional, Crow, Mary K., additional, Crump, John A., additional, Cullen, Mark R., additional, Curhan, Gary C., additional, Damon, Inger K., additional, Daniels, Troy E., additional, Davidson, Nancy, additional, DeAngelis, Lisa M., additional, DeCamp, Malcolm M., additional, Del Rio, Carlos, additional, Demetri, George D., additional, Demling, Robert H., additional, Deuster, Patricia A., additional, Diasio, Robert B., additional, Diemert, David J., additional, Digre, Kathleen B., additional, Douglas, John M., additional, Drazen, Jeffrey M., additional, Dreskin, Stephen C., additional, Drew, W. Lawrence, additional, Drusano, George L., additional, DuBose, Thomas D., additional, Duffy, F. Daniel, additional, DuPont, Herbert L., additional, Duvic, Madeleine, additional, Edwards, Kathryn M., additional, Edwards, N. Lawrence, additional, Einhorn, Lawrence H., additional, Elin, Ronald J., additional, Eliopoulos, George M., additional, Elliott, Perry, additional, Ellner, Jerrold J., additional, Elsas, Louis J., additional, Elston, Dirk M., additional, Emanuel, Ezekiel J., additional, Erickson, Gregory F., additional, Ernst, Armin, additional, Ernst, Joel D., additional, Ettinger, David S., additional, Evoli, Amelia, additional, Faigel, Douglas O., additional, Falk, Gary W., additional, Favus, Murray J., additional, Feder, Gene, additional, Fihn, Stephan D., additional, Firestein, Gary S., additional, Fishman, Neil, additional, Fleisher, Lee A., additional, Ford, Marsha D., additional, Forsmark, Chris E., additional, Fowler, Vance G., additional, Fox, Jay W., additional, Franco, Manuel A., additional, French, Martyn A., additional, Freund, Karen, additional, Fried, Linda P., additional, Gabay, Cem, additional, Gage, Kenneth L., additional, Gagel, Robert F., additional, Galgiani, John N., additional, Gallagher, Patrick G., additional, Galun, Eithan, additional, Ganz, Leonard, additional, Garcia-Tsao, Guadalupe, additional, Gates, Jonathan D., additional, Geisler, William M., additional, George, Tony P., additional, Gerding, Dale N., additional, Gershwin, M. Eric, additional, Gertz, Morie A., additional, Ginder, Gordon D., additional, Ginsberg, Jeffrey, additional, Ginsburg, Geoffrey S., additional, Glogauer, Michael, additional, Gnann, John W., additional, Golden, Matthew R., additional, Goldman, Lee, additional, Goldstein, Ellie J., additional, Goodnough, Lawrence T., additional, Goronzy, Jörg J., additional, Gotuzzo, Eduardo, additional, Grady, Deborah, additional, Grammer, Leslie C., additional, Greco, F. Anthony, additional, Greenberg, Harry B., additional, Gregersen, Peter K., additional, Griggs, Robert C., additional, Guay-Woodford, Lisa M., additional, Guerrant, Richard L., additional, Hadigan, Colleen, additional, Hainsworth, John D., additional, Hamsten, Anders, additional, Hande, Kenneth R., additional, Handsfield, H. Hunter, additional, Hansson, Göran K., additional, Haque, Rashidul, additional, Harris, Raymond C., additional, Hauser, Stephen Crane, additional, Hayden, Frederick G., additional, Healey, Letha, additional, Heimburger, Douglas C., additional, Hewlett, Erik L., additional, Hill, David R., additional, Hill, Nicholas S., additional, Hillis, L. David, additional, Hirsh, Jack, additional, Holers, V. Michael, additional, Holland, Steven M., additional, Hollenberg, Steven, additional, Hook, Edward W., additional, Huang, Laurence, additional, Hudson, Leonard D., additional, Hyman, Steven E., additional, Iannuzzi, Michael, additional, Inman, Robert D., additional, Inouye, Sharon K., additional, Insogna, Karl L., additional, Inzucchi, Silvio E., additional, Isselbacher, Eric M., additional, Jemal, Ahmedin, additional, Jen, Joanna, additional, Jensen, Dennis M., additional, Jensen, Michael D., additional, Jensen, Robert T., additional, Jessup, Mariell, additional, Johnson, Stuart, additional, Józefowicz, Ralph F., additional, Kaler, Stephen G., additional, Kamya, Moses R., additional, Kantarjian, Hagop, additional, Karp, David R., additional, Kastner, Daniel L., additional, Katzka, David A., additional, Katzman, Debra K., additional, Kauffman, Carol A., additional, Kaushansky, Kenneth, additional, Keeffe, Emmet B., additional, Kern, Morton, additional, Keusch, Gerald T., additional, Kim, David H., additional, Kim, Matthew, additional, Kirchhoff, Louis V., additional, Klag, Michael J., additional, Klein, Samuel, additional, Knopman, David S., additional, Knox, Tamsin A., additional, Ko, Albert I., additional, Komrokji, Rami S., additional, Kontoyiannis, Dimitrios P., additional, Koppel, Barbara S., additional, Korenblat, Kevin, additional, Korf, Bruce R., additional, Korman, Neil J., additional, Kovacs, Joseph A., additional, Kraft, Monica, additional, Kramer, Christopher M., additional, Krasnewich, Donna M., additional, Krause, Peter J., additional, Kronenberg, Henry M., additional, Kuipers, Ernst J., additional, Ladenson, Paul, additional, Landry, Donald W., additional, Lane, Nancy E., additional, Lang, Anthony E., additional, Lange, Richard A., additional, Lawry, George V., additional, Lee, Thomas H., additional, Lee, William M., additional, Leggett, James, additional, Lerner, Adam, additional, Levin, Stuart, additional, Levine, Stephanie M., additional, Lichtenstein, Gary R., additional, Lim, Henry W., additional, Lima, Aldo A.M., additional, Limper, Andrew H., additional, Ling, Geoffrey S.F., additional, List, Alan F., additional, Little, William C., additional, Loeser, Richard F., additional, Lorber, Bennett, additional, Low, Donald E., additional, Lucey, Daniel R., additional, Lupski, James R., additional, Lynch, Henry T., additional, Lyness, Jeffrey M., additional, Lytle, Bruce W., additional, MacKenzie, C. 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Published
2012
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298. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses.

Author

Cervantes Rincón, Tomás, Kapoor, Tania, Keeffe, Jennifer R., Simonelli, Luca, Hoffmann, Hans-Heinrich, Agudelo, Marianna, Jurado, Andrea, Peace, Avery, Lee, Yu E., Gazumyan, Anna, Guidetti, Francesca, Cantergiani, Jasmine, Cena, Benedetta, Bianchini, Filippo, Tamagnini, Elia, Moro, Simone G., Svoboda, Pavel, Costa, Federico, Reis, Mitermayer G., and Ko, Albert I.

Abstract

Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics. [Display omitted] • Sera from Mexico and Brazil neutralize POWV and TBEV, which are not known to circulate there • Monoclonal antibody P014 binds to POWV but not to endemic flaviviruses • Monoclonal antibodies P002 and P003 neutralize POWV lineage I • The P003 epitope is shared across 13 flaviviruses from tick and mosquito serocomplexes Cervantes Rincón et al. describe antibody neutralizing activity against Powassan virus from regions of the Americas where this flavivirus transmitted by ticks is not known to circulate. Two monoclonal antibodies to the EDIII (P002 and P003) are broadly cross-reactive against tick- and mosquito-borne flaviviruses. [ABSTRACT FROM AUTHOR]

Published
2024
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