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1,083 results on '"Kim, Jinwoong"'

273. Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response.

Author

Seo, Ji Yeon, Pyo, Euisun, An, Jin-Pyo, Kim, Jinwoong, Sung, Sang Hyun, and Oh, Won Keun

Subjects
ALZHEIMER'S disease treatment, ANDROGRAPHIS paniculata, INFLAMMATION, MICROGLIA, NITRIC-oxide synthases, TRANSCRIPTION factors, HEME oxygenase
Abstract

Therapeutic approach of Alzheimer’s disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (Aβ)42-induced microglial activation related to Nrf2 and nuclear factor κB (NF-κB)-mediated inflammatory responses. Andrographolide induced the expression and translocation of Nrf2 from the cytoplasm to the nucleus, thereby activating antioxidant response element (ARE) gene transcription and HO-1 expression in murine hippocampal HT22 cells. Andrographolide eliminated intracellular Aβ42 in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1β, prostaglandin (PG)E2, and nitric oxide (NO) because of artificial phagocytic Aβ42. It decreased pNF-κB accumulation in the nucleus and the expression of inducible nitric oxide synthase (i-NOS) and cyclooxygenase II (COX-II) in the microglial BV-2 cell line. In summary, andrographolide activates Nrf2-mediated HO-1 expression and inhibits Aβ42-overexpressed microglial BV-2 cell activation. These results suggested that andrographolide might have the potential for further examination of the therapeutics of AD. [ABSTRACT FROM AUTHOR]

Published
2017
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274. 84‐5: Late‐News‐Paper:Flexible Cover Window Film with Improved Optical Clarity

Author

Park, Min Sang, Kim, Sun Kug, Park, Sangyoon, Yoon, Ho Chul, and Kim, Jinwoong

Abstract

SK Innovation and SK ie technology have developed and commercialized cover window films (FCW®) composed of functional coatings on transparent polyimide (PI) film for a foldable displays. We report on the development of PI film with high visual clarity, which can provide glass‐like feel to public users. Advances were achieved by engineering drying kinetics on the process of film fabrication, and the technology is applied to the commercial product of transparent PI film.

Published
2020
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277. Stereoisomer-Specific Anticancer Activities of Ginsenoside Rg3 and Rh2 in HepG2 Cells: Disparity in Cytotoxicity and Autophagy-Inducing Effects Due to 20(S)-Epimers

Author

Cheong, Jong Hye, primary, Kim, Hyeryung, additional, Hong, Min Jee, additional, Yang, Min Hye, additional, Kim, Jung Wha, additional, Yoo, Hunseung, additional, Yang, Heejung, additional, Park, Jeong Hill, additional, Sung, Sang Hyun, additional, Kim, Hong Pyo, additional, and Kim, Jinwoong, additional

Published
2015
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280. Flavonoids from Symplocos racemosa

Author

Jung, Mila, primary, Choi, Janggyoo, additional, Chae, Hee-Sung, additional, Cho, Jae, additional, Kim, Young-Dong, additional, Htwe, Khin, additional, Lee, Woo-Shin, additional, Chin, Young-Won, additional, Kim, Jinwoong, additional, and Yoon, Kee, additional

Published
2014
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