251. Screening for ciliary dyskinesia - a spectrum of defects of motility and structure.
- Author
-
Rutland J, Cox T, Dewar A, and Cole P
- Subjects
- Adolescent, Adult, Bronchiectasis physiopathology, Cilia enzymology, Cilia physiology, Cystic Fibrosis physiopathology, Dyneins analysis, Humans, Kartagener Syndrome physiopathology, Microtubules ultrastructure, Middle Aged, Movement, Smoking, Bronchiectasis pathology, Cilia ultrastructure, Cystic Fibrosis pathology, Kartagener Syndrome pathology, Nasal Mucosa ultrastructure
- Abstract
Ciliary motility and ultrastructure were studied in cystic fibrosis, bronchiectasis and Kartagener's syndrome and normal control subjects. In cilia from patients with Kartagener's syndrome, beat frequency was slower and there were more microtubular abnormalities and fewer dynein arms than for each of the other groups. In Kartagener's syndrome, ciliary motility and outer dynein arm numbers were positively correlated and there was a wide variation in each. Cystic fibrosis ciliary beat frequency and ultrastructure were normal.
- Published
- 1983