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1,399 results on '"Kabala A"'

252. Evolution of the Cure Rate of Pulmonary Tuberculosis in Mbujimayi Case of the General Reference Hospital (HGR) Franciscan Sisters of Lukelenge, Democratic Republic of the Congo

Author

Georges, Kabeya Kalala, primary, Charles, Katuku Ciala, additional, Justin, Tshibangu Kandala, additional, Lievin, Mukendi Ngeleka, additional, Roger, Cimpangila Kalonji, additional, Roger, Kamwema Shamuana, additional, Erick, Mutombo Mukuta, additional, Paul, Ciamala Mukendi, additional, and David, Kabala Muana Mbuyi, additional

Published
2022
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256. VP010 INTRA-ABDOMINAL HERNIA AS A CAUSE OF ACUTE SMALL INTESTINE OBSTRUCTION. LAPAROSCOPIC EMERGENCY TREATMENT - SMALL INTESTINE OBSTRUCTION DUE TO INTERNAL HERNIA WITH CONCOMITANT ACALCULOUS CHOLECYSTITIS

Author

Przemysław Kabala, Szymon Jasiński, Janusz Świątkiewicz, and Dariusz Tomaszewski

Subjects
Internal hernia, medicine.medical_specialty, business.industry, Intra-abdominal hernia, Concomitant, Medicine, Surgery, Acalculous cholecystitis, Emergency treatment, business, Small intestine obstruction
Abstract

Aim Nowadays, in vast majority of emergency patients with gastrointestinal obstruction laparoscopy is not the treatment of choice. In our department laparoscopy is routinely used in emergency admitted patients, also those with abovementioned condition, sometimes yielding unexpected and thrilling results. The aim of this work is to present a laparoscopic internal hernia repair with simultaneous “Phrygian-cap-type” gallbladder excision, performed on a patient with small intestine obstruction and chronic acalculous cholecystitis. Material and Methods A 57-year-old patient was admitted to our department as an emergency, with a one week history of symptomatic cholecystitis accompanied by gastrointestinal obstruction. CT revealed atypical suprahepatic displacement of the small intestine. An attempt of conservative treatment failed after the re-initiation of oral nutrition. The patient was qualified for laparoscopy. Results An anatomical variant of the liver ligaments was visualized with two defects in the anteriorly displaced coronary ligament and shortening of the falciform ligament. Those defects formed the hernia ring entrapping a small intestine of a total length of about 1.5 m. The falciform ligament was dissected. To avoid re-entrapment of the intestine, most of the coronary ligament was severed. Consecutively the inflamed gallbladder was removed. The unusual anatomical variation of its structure, the so-called “Phrygian cap”, was an additional difficulty. The postoperative course was uneventful. Conclusions The presented material demonstrates the possibility of immediate treatment of intestinal obstruction, even in a complicated cases, with laparoscopic manner, without the need of conversion to the open method.

Published
2021

258. The nucleocapsid protein of human coronavirus NL63.

Author

Kaja Zuwała, Anna Golda, Wojciech Kabala, Michał Burmistrz, Michal Zdzalik, Paulina Nowak, Sylwia Kedracka-Krok, Mirosław Zarebski, Jerzy Dobrucki, Dominik Florek, Sławomir Zeglen, Jacek Wojarski, Jan Potempa, Grzegorz Dubin, and Krzysztof Pyrc

Subjects
Medicine, Science
Abstract

Human coronavirus (HCoV) NL63 was first described in 2004 and is associated with respiratory tract disease of varying severity. At the genetic and structural level, HCoV-NL63 is similar to other members of the Coronavirinae subfamily, especially human coronavirus 229E (HCoV-229E). Detailed analysis, however, reveals several unique features of the pathogen. The coronaviral nucleocapsid protein is abundantly present in infected cells. It is a multi-domain, multi-functional protein important for viral replication and a number of cellular processes. The aim of the present study was to characterize the HCoV-NL63 nucleocapsid protein. Biochemical analyses revealed that the protein shares characteristics with homologous proteins encoded in other coronaviral genomes, with the N-terminal domain responsible for nucleic acid binding and the C-terminal domain involved in protein oligomerization. Surprisingly, analysis of the subcellular localization of the N protein of HCoV-NL63 revealed that, differently than homologous proteins from other coronaviral species except for SARS-CoV, it is not present in the nucleus of infected or transfected cells. Furthermore, no significant alteration in cell cycle progression in cells expressing the protein was observed. This is in stark contrast with results obtained for other coronaviruses, except for the SARS-CoV.

Published
2015
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260. Kenyan Catholics' Religiosity and Understanding of Marriage on the Basis of Individuals Associated with Shalom Center in Mitunguu: Educational and Pastoral Perspective.

Author

Goleń, Jacek, Kobak, Jan, Kabala, Florence, and Szyszka, Małgorzata

Subjects
MARRIAGE, RELIGIOUSNESS, RELIGIOUS education, PASTORAL care, CATHOLICS, INTERMARRIAGE
Abstract

This article presents the results of research into religiosity and understanding of marriage among a selected group of young Catholics, all of whom are current students or graduates of Shalom Center in Mitunguu, Kenya. The goal of our study was to determine the correlations between the two variables so as to reach some conclusions and suggestions for religious education and pastoral care. The research made use of Stefan Huber's Centrality of Religiosity Scale, while the respondents' understanding of marriage was analyzed with the use of a questionnaire prepared by the authors of this study. As our research shows, one's Catholic understanding of marriage increases alongside an increase in interest in religiosity and in one's religious convictions, while it does not correlate—or does so only weakly—with a centrality of religiosity. Correlations with centrality occurred more often among men than among women. Mutual connections were most frequent among the youngest group of respondents, those who were up to 20 years of age and current students. This may indicate that religious formation and education of youth in the Shalom Center exerts a clear impact on shaping Catholic views on marriage. With the passing of time, traditional cultural precepts seem to gain prominence among the graduates. [ABSTRACT FROM AUTHOR]

Published
2023
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262. Body Morphology and Drag in Swimming: CFD Analysis of the Effects of Differences in Male and Female Body Types

Author

Zbigniew Kabala and Andrew Wang

Subjects
Fluid Flow and Transfer Processes, Mechanical Engineering, computational fluid dynamics (CFD), drag coefficient, swimming, body morphology, streamline, male and female body type comparison, Condensed Matter Physics
Abstract

This study analyzes the effect of the morphological characteristics of swimmers on passive drag and determines whether the female or male body type is more efficient for gliding. As a result of puberty, males and females develop different body structures; this study investigates whether these changes in shape influence drag. Computational fluid dynamics (CFD) simulations carried out in Ansys Fluent software were used to calculate the drag force and coefficient from 2D models of swimmers in streamline position, generated based on common anthropometric measurements. Both the top and side view profiles of the swimmers were simulated, unique to this study. The normalized male and female body shapes were simulated at different velocities, and it was demonstrated that the male body shape has a lower drag coefficient than the female body shape by 10.1% and 2.8% for top view and side view profiles, respectively. The in-depth analysis and simulation of models with varying hip and chest dimensions found a significant and positive correlation between hip and chest size and drag, with the chest size having the largest effect of an average 12.2% increase in drag per 5% increase in chest breadth. The results from modifying anthropometric variables explain the discrepancy between the drag experienced by male and female swimmers and show that enlarged hips and chests cause an increase in resistance. The differences between drag for males and females were found to be comparable to the 6.2% and 7.7% drag differences between full-body fastskin and normal suits, indicating measurable impact on performance. These findings suggest that the morphology of swimmers does have a significant effect on drag and that the male body shape is more hydrodynamic than the female body shape.

Published
2022

273. Review of The Socratic Method Today: Student-Centered and Transformative Teaching in Political Science

Author

Boleslaw Z. Kabala

Subjects
Transformative learning, Sociology and Political Science, Political science, Pedagogy, Student centered, Elite, Socratic method, Education
Abstract

I first heard of the Socratic method on a tour of Phillips Exeter Academy, one of the elite boarding schools in the US (Martin and Browning 2015) and in the world (PrepPreview.com 2019). With huge ...

Published
2019

274. The return of the intolerant Hobbes

Author

Boleslaw Z. Kabala

Subjects
Philosophy, History, Politics, Social contract, Sociology and Political Science, media_common.quotation_subject, Toleration, LEVIATHAN (cipher), media_common, Law and economics
Abstract

Thomas Hobbes in Leviathan presented a paradigm of the social contract that has proven foundational in Western political thought. A proper understanding of the philosopher’s thought is thus of para...

Published
2019

275. Disorders of Sex Development Are an Emerging Problem in French Bulldogs: A Description of Six New Cases and a Review of the Literature

Author

Anna Jastrzebska, Izabela Szczerbal, Wojciech Niżański, Przemysław Przadka, Monika Biernacik, Zuzanna Ligocka, Bartlomiej Kabala, Marek Switonski, Joanna Nowacka-Woszuk, and Stanisław Dzimira

Subjects
Embryology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, biology.animal_breed, Population, Disorders of Sex Development, 030232 urology & nephrology, 030209 endocrinology & metabolism, French bulldog, Breeding, 03 medical and health sciences, Dogs, 0302 clinical medicine, medicine, Animals, Disorders of sex development, Gonads, education, Gynecology, education.field_of_study, biology, Ovotestis, Karyotype, medicine.disease, Freemartinism, Testis determining factor, Hypospadias, Female, France, Developmental Biology
Abstract

Disorders of sex development (DSD) are a well-known cause of sterility and reduced fertility in dogs. Here, we report on 6 new cases of DSD in French bulldogs diagnosed by us within the last year. The animals were phenotypical females who underwent detailed diagnosis due to the presence of an enlarged clitoris or a penis-like structure with atypically located urethral orifice (hypospadias). A female karyotype (78,XX) and lack of Y-linked genes (SRY and ZFY) were observed in 5 cases, which were classified as XX (SRY-negative) DSD. Gonads histology could be performed in 4 XX DSD cases: testicular tissue was observed in 3 cases and ovotesticular tissue in 1 case. In the last case, leukocyte chimerism (XX/XY) was detected alongside an ovotestis with epididymis and fallopian tubes. This case was classified as freemartinism. Our study and a literature review showed that heritable XX (SRY-negative) DSD is quite common in French bulldogs, but spontaneously developed freemartinism can be also diagnosed. In conclusion, we postulate that the description of the sexual phenotype of DSD females (enlarged clitoris and presence of testicular tissue) does not distinguish between hereditary XX DSD and nonhereditary freemartinism. Cytogenetic and molecular analyses are thus necessary to correctly diagnose such cases. This is especially important for the French bulldog breed, as a rapid increase in its population could spread hereditary DSD.

Published
2019

276. Economic evaluation of alternative process chains for the large-scale manufacturing of metal-fibre laminates

Author

Jan Beuscher, Philipp Kabala, Klaus Dröder, Christoph Herrmann, Sebastian Thiede, Felix Rothe, and Antal Dér

Subjects
Pressing, 0209 industrial biotechnology, Lever, business.product_category, Bending (metalworking), Total cost, Computer science, business.industry, Automotive industry, Mechanical engineering, 02 engineering and technology, 010501 environmental sciences, Alternative process, 01 natural sciences, Value stream mapping, 020901 industrial engineering & automation, General Earth and Planetary Sciences, Production (economics), business, 0105 earth and related environmental sciences, General Environmental Science
Abstract

Hybrid bending plates consisting of fibre-metal laminates (FML) facilitate an individual spring rate at constant component geometry for a wide variety of vehicles, sports equipment and prostheses. The spring rate of such a FML is adjusted by an alternating layer setup of the two materials. Based on the technological potential of hybrid bending plates, this paper evaluates and compares the production costs of hybrid bending plates against composite bending plates in different manufacturing scenarios. For this purpose, the manufacturing processes RTM and prepreg pressing are compared. Three applications scenarios (automotive, sports equipment and running prosthesis), each with different production volumes and number of variants serve the bases for the economic evaluation. The production costs of the resulting process chains are modeled based on the value stream method. While fibre-metal laminates cause reduced tooling costs in all assessed scenarios, higher material costs tend to overcompensate this effect. Material costs seem to have the biggest lever in reducing total costs. Further research hence may be undertaken to investigate the effect of an optimised FML layer structure on the material costs.

Published
2019

277. Between Defectological Narratives and Institutional Realities: The 'Mentally Retarded' Child in the Soviet Union of the 1930s

Author

Maria Cristina Galmarini-Kabala

Subjects
History, Adolescent, media_common.quotation_subject, Persons with Mental Disabilities, Medicine (miscellaneous), Socialist mode of production, Social integration, medicine, Humans, 0601 history and archaeology, Narrative, Marxist philosophy, Sociology, Child, General Nursing, Communism, media_common, Socialism, Gender studies, 06 humanities and the arts, General Medicine, History, 20th Century, 060105 history of science, technology & medicine, Child, Preschool, Rhetoric, Learning disability, Ideology, medicine.symptom, Soviet union, USSR
Abstract

This article analyzes the gap between the defectological narrative of care and the reality of institutional life for children with learning disabilities in the Soviet Union of the 1930s. It shows that, under Stalin, the Soviet discipline of defectology entailed a promise of correction and social integration that aligned well with the official rhetoric of triumphant socialism and that incorporated new, specific ideological meanings into its long-standing narrative of care. I also show that the defectological narrative was rarely realized in practice due to not only scarce material resources but also a profound reversal of defectological and Marxist conceptions of labor. By analyzing the disconnect between rhetoric and reality in the treatment of "mentally retarded" children in prewar Stalinism, this article contributes to a deeper understanding of the Soviet system and ideology of care.

Published
2019

279. Assessment of in vitro Antioxidant and Antidiabetic Capacities of Medlar (Mespilus germanica)

Author

Sebnem Selen Isbilir, Hulya Yagar, and Sevilay Inal Kabala

Subjects
Antioxidant, amylase inhibition, DPPH, medicine.medical_treatment, Flavonoid, Plant Science, Horticulture, glucosidase inhibition, Ethanol extracts, chemistry.chemical_compound, medicine, Food science, Mespilus, Tocopherol, medlar leaf, chemistry.chemical_classification, biology, Bud, fungi, food and beverages, biology.organism_classification, In vitro, chemistry, phenolic content, DPPH scavenging, Agronomy and Crop Science
Abstract

The objective of the current study was to evaluate the antioxidant activity and enzyme inhibitory effect of different parts of medlar including fruit, leaf and flower bud by using various in vitro methods, and also determination of total phenolic and flavonoid content in the samples. Ethanol extracts of medlar parts were prepared and their antioxidant activities were determined using 1,1-diphenyl-2-picryl-hydrazil (DPPH•) scavenging and β-carotene bleaching methods. The leaf extract showed the strongest antioxidant activity. DPPHradical scavenging activity was in the order of BHA > leaf > bud > fruit. This ordering was the same for β-carotene bleaching activity, tocopherol > leaf > bud > fruit. The highest total phenolic (60.3 ± 1.69 mg GAE g-1 extract) and flavonoid (14.77 ± 1.15 mg QE g-1 extract) content were determined in leaf extract. For possible antidiabetic effects of extracts, α-amylase and α-glucosidase inhibitory activities were investigated, the bud extract showed the highest inhibition activities among the all extracts.

Published
2018

280. Virtual parameter identification of the forming behaviour of discontinuous fibre reinforced thermoplastic composite sheets

Author

Philipp Kabala, Tim Ossowski, Jan Beuscher, André Hürkamp, and Klaus Dröder

Subjects
Fiber reinforcement, Materials science, Breakage, Uniaxial tension, Formability, Composite material, Displacement (fluid), Thermoforming, Thermoplastic composites, Tensile testing
Abstract

Fibre-reinforced thermoplastics (FRTP), such as organo sheets or laminates, are increasingly being used in large-scale automotive production. The high weight-saving potential, high specific strengths and stiffnesses as well as processing times suitable for large-scale production are some of the reasons for using these materials. However, the formability of such semi-finished products is severely limited by the fibre reinforcement, which can lead to fibre breakage, fibre displacement or wrinkling in complex-shaped components. In order to increase the formability, an FRTP semi-finished product is developed, which consists of discontinuous tapes. Due to the local sliding of the tape sections, a pseudo-plastic material behaviour is achieved. Experimental uniaxial tensile tests at elevated temperatures are used to investigate the forming behaviour of the material for different tape lengths and overlap lengths. Subsequently, this tensile test is numerically modelled in order to fit the pseudo-plasticity to the experimental data by a virtual parameter identification. With the help of the parameters determined from the numerical tensile test, the sliding behaviour of the tape sections can be used for forming simulations in order to achieve a higher prediction quality.

Published
2021

282. COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Author

Jérôme Avouac, Elodie Drumez, Eric Hachulla, Raphaèle Seror, Sophie Georgin-Lavialle, Soumaya El Mahou, Edouard Pertuiset, Thao Pham, Hubert Marotte, Amélie Servettaz, Fanny Domont, Pascal Chazerain, Mathilde Devaux, Pascal Claudepierre, Vincent Langlois, Arsène Mekinian, Alexandre Thibault Jacques Maria, Béatrice Banneville, Bruno Fautrel, Jacques Pouchot, Thierry Thomas, René-Marc Flipo, Christophe Richez, Florence Aeschlimann, Christian Agard, Nassim Ait-Abdallah, Jean-David Albert, Didier Alcais, Jean-Sébastien Allain, Yannick Allanore, Blanca Amador-Borreiro, Zahir Amoura, Emma Andre, Anaïs Arbault, Jean-Benoît Arlet, Laurent Arnaud, Denis Arniaud, Herliette Arty-Hue, Lucie Atlan, Alexandra Audemard-Verger, Christine Audoin-Pajot, Victor Audren, Maxime Bach-Bunner, Hélène Bacquet-Deschryver, Brigitte Bader-Meunier, Nathalie Balandraud, Jean-Charles Balblanc, Stéphane Bally, Frédéric Banal, Pierre Barbery, Thomas Barnetche, Audre Barrelet, André Basch, Vincent Baumier, Guillaume Bayer, Sophie Bayle, Catherine Beauvais, Rudie Beinat, Véronique Belin, Rakiba Belkhir, Ruben Benainous, Alexandre Belot, Mohammed Benammar, Mathilde Benhamou, Ygal Benhamou, Ahmed Benmansour, Pascal Bennet, Brigitte Bernoux-Manat, Elise Berthet, Emilie Berthoux, Ewa Bertolini, Adrien Bigot, Aurélia Bisson-Vaivre, Gilles Blaison, Gilles Bolla, Olivier Bonidan, Christine Bonnet, Raphaël Borie, Marie Bossert, Laurence Boudou, Françoise Bouhour, Kévin Bouiller, Bastien Bouldoires, Karima Boussoualim, Eric Bouvard, Regine Brondino, Pierre Buchlin, Laurence Cabantous, Patrice Cacoub, Simon Cadiou, Maurizio Carteni, Aurélia Carbasse, Brice Castel, Pascal Cathebras, Hervé Caumont, Annalisa Celant, Benjamin Chaigne, Benoît Chaillous, Romuald Champy, Agnès Charcot, Pierre Charles, Isabelle Charlot-Lambrecht, Caroline Charpin, Emmanuel Chatelus, Bernard Chaudier, Pascale Chertok, Xavier Chevalier, Maxime Chevreau, Emilie Chotard, Delphine Chu Miow Lin, Gaëlle Clavel, Cyril Clavel-Osorio, Fleur Cohen, Gregory Cohen, Marie-Eve Colette-Cedoz, Nived Collercandy, Antoine Colombey, Chloé Comarmond, Bernard Combe, Céline Comparon, Elodie Constant, Pascal Coquerelle, Justine Corli, Clémence Corre, Nathalie Costedoat-Chalumeau, Marie Couret, Natacha Courvoisier, Fabienne Coury-Lucas, Cécile Coutarel, Fabrice Coutier, Richard Damade, Laurence Daver-Malaterre, Sarahe Dehimat, Michel Delahousse, Emilie Barrois-Delattre, Delphine Denarie, Camille Deprouw, Emanuelle Dernis, Alban Deroux, Renaud Desbarbieux, Elise Descamps, Chantal Deslandre, Marie Desmurs, Jacques Despaux, Marie Desplats, Frédérick Detree, Valérie Devauchelle-Pensec, Robin Dhote, Philippe Dieude, Yannick Dieudonne, Elisabeth Diot, Guillaume Direz, Djamal-Dine Djeddi, Sarah Douvier, Béatrice Drouet, Catherine Duc, Angélique Ducornet, Carine Dufauret-Lombard, Alain Duhamel, Cécile Dumaine, Anne-Elisabeth Dumel, Chantal Dumoulin-Richez, Agnès Duquesne, Géraldine Durand, Mariane Durandin-Truffinet, Pierre-Marie Duret, Maïka Duval, Mikaël Ebbo, Esther Ebstein, Andra Economu-Dubosc, Stéphanie Emilie, Romain Euvrard, Philippe Evon, Sylvie Fabre, Dorothée Fagedet, Meryem Farhat, Marion Fauconier, Jacques Fechtenbaum, Renaud Felten, Fanny Fernandes, Nicole Ferreira-Maldent, Elodie Feurer, Amandine Fichet, Françoise Flaisler, Nans Florens, Violaine Foltz, Elisabeth Fontanges, Jennifer Foret, Anne-Claire Fougerousse, Anne Fouque-Aubert, Catherine Foutrier-Morello, Hélène Francois-Pradier, Léa Frantzen, Pierre Fritz, Antoine Froissart, Jean Fulpin, Piera Fuzibet, Francis Gaches, Laurence Gagneux-Lemoussu, Mélanie Penhoat-Gahier, Joris Galland, Frédérique Gandjbakhch, Nicole Garnier, Thomas Garraud, Jean-François Garrot, Romain Gastaldi, Véronique Gaud-Listrat, Maud Gauthier-Prieur, Dana Georgescu, Nathalie Gerard, Elisabeth Gervais, Christelle Gibert, Eric Gibert, Ghislaine Gill, Jérôme Gillard, Mélanie Gilson, Pauline Gimonnet, Jeanine-Sophie Giraudet-Le Quintrec, Aude Giraud-Morelet, Baptiste Glace, Camille Glanowski, Bertrand Godeau, Bruno Gombert, Camille Gonnet-Gracia, Tiphaine Goulenok, Philippe Goupille, Olivier Gourmelen, Sophie Govindaraju-Audouard, Franck Grados, Martine Grall-Lerosey, Bruno Grardel, Anne Grasland, Gilles Grateau, Monica Groza, Constance Guillaud, Séverine Guillaume, Caroline Guillibert, Xavier Guillot, Philippe Guilpain, Aline Gury, Marie-Hélène Guyot, Cécile Hacquard-Bouder, Marie-Noelle Havard, Jean-Pierre Hellier, Pascal Hennequin, Basile Henriot, Julien Henry, Véronique Hentgen, Marion Hermet, Muriel Herasse, Julie Hernandez, Miguel Hie, Pascal Hilliquin, Olivier Hinschberger, Ambre Hittinger-Roux, Jan Holubar, Christophe Hudry, Serge Huguenel, Clara Jaccard, Jean-Michel, Jacquemier, Bénédicte Jamard, Catherine Jan, Sylvie Jean, Mathieu Jouvray, Pierre-Antoine Juge, Laurent Juillard, Denis Jullien, Anna Kabala, Abdelkrim Kabchou, Ludovic Karkowski, Françoise Karman, Farid Kemiche, Jérémy Keraen, Pierre Kieffer, Isabelle Kone-Paut, Abdeldajallil Koreichi, Marie Kostine, Sylvain La Batide Alanore, Pierre Lafforgue, Sophie Lahalle, Marc Lambert, Isabelle Lambrecht, Sylvain Lanot, Aurélia Lanteri, Jean-Paul Larbre, Augustin Latourte, Christian Lavigne, Sophie Le Guen Guegan, Guillaume, Le Guenno, Diane Leguy, Agnès Lebrun, Emmanuel Ledoult, Nathalie Legoupil, Erick Legrand, Charlotte Lejeune, Olivier Leloire, Christophe Leroux, Rémi Leroy, Marie Leroy-Gouix, Tifenn Leturcq, Amélie Leurs, Céline Leveque-Michaud, François-Xavier Limbach, Frédéric Liote, Anne Lohse, Pierre Lozac'h, Virginie Lucas, Aurélie Madelon, Nadine Magy-Bertrand, Matthieu Mahevas, Hélène Maillard, Thibault Maillet, Sandrine Malochet-Guinamand, Quentin Mangon, Sylvie Marchou-Lopez, Nathalie Margarit, Thierry Marhadour, Xavier Mariette, Claire Martin, Alexis Mathian, François Maurier, Frédéric Maury, Betty Mazet-Guillaume, Arnaud Mazouyez, Hassan Mazyad, Nadia Mehsen-Cetre, Ulrich Meinzer, Isabelle Melki, Laurent Messer, Corinne Miceli, Martin Michaud, Catherine Michel, Matthias Michel, Mathilde Michon, Anne-Marie Milesi-Lecat, Anna Molto, Marie Moly, Olivier Moranne, Gautier Morel, Hugo Morel, Jacques Morel, Franck Morin, Laurence Moulinier, Guillaume Moulis, Bertrand Moura, Minh Nguyen, Sabine Nicolas-Vullierme, Hubert Nielly, Gaétane Nocturne, Aurore Nottez, Henri-Olivier Ollagnon, Isabelle Pacaud-Vitoux, Anne Pagnier, Caroline Paris, Antoine Parrot, Tristan Pascart, Yasmina Pascaud-Mansour, Lætitia Paulin, Stephan Pavy, Laurent Perard, Yves-Marie Pers, Micheline Pha, Maud Pichon, Audrey Pierreisnard, Gabrielle Pizana, Sylvaine Poignant, Elsa Poix, Agnès Portier, Antoine Poulet, Samira Plassard, Grégory Pugnet, Déborah Puyraimond-Zemmour, Pierre Quartier-Dit-Maire, Marion Quenet, Viviane Queyrel, Loïc Raffray, Philippe Remy, Myriam Renard, Jessica Rene, Sabine Revuz, Bénédicte Rey, Gaëlle Richard-Colmant, Etienne Riviere, Sébastien Riviere, Sophie Robin, Julien Rohmer, Isabelle Roitg, Mélanie Romier, Michel Rolland, Mélanie Roriz, Carole Rosenberg, Linda Rossi, Olivier Roth, Sid-Ahmed Rouidi, Mathilde Roumier, Mickaël Rousiere, Clémentine Rousselin, Bénédicte Rouviere, Christian Roux, Fabienne Roux, Marielle Roux, Nicolas Roux, Diane Rouzaud, Sylvie Rozenberg, Isabelle Sacco, Fatiha Sadji, Laurent Sailler, Carine Salliot, Jean-Hugues Salmon, Alain Saraux, Jean Schmidt, Julie Seguier, Jérémie Sellam, Eric Senbel, Thomas Sene, Patricia Senet, Pascal Seve, Aurélie Sicaud, Perrine Smets, Vincent Sobanski, Christelle Sordet, Elisabeth Sornay-Rendu, Odile Souchaud-Debouverie, Lætitia Sparsa, Lionel Spielmann, Sarah Steib, Chloé Stavris, Catherine Straus, Victor Strotz, Paulina Szafors, Séverine Taffignon-Clave, Justine Simoens, Claire Theillac, Nora Tenenbaum, Benoît Thomachot, Nathalie Tieulie, Soizic Tiriau, Alice Tison, Eric Toussirot, Ludovic Trefond, Sophie Trijau, Sébastien Trouillier, Anne-Priscille Trouvin, Marie-Elise Truchetet, Marc Ulrich, Jacques Vaquier, Eric Veillard, Laurent Veillon, Guillaume Vial, Jean-François Viallard, Judith Victor, Claire Vidon, Mathias Vidon, Camille Vigne, Alexandre Virone, Ursula Warzocha, Daniel Wendling, Claude Werle, Cécile Wibaux, Alexandra Willems, Michel Wisniewski, Juliette Woessner, Bernadette Xerri-Campano, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de médecine interne [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Tourcoing, Centre Hospitalier René Dubos [Pontoise], Assistance Publique - Hôpitaux de Marseille (APHM), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie Intégrative du Tissu Osseux (LBTO), Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Pitié-Salpêtrière [AP-HP], Groupe Hospitalier Diaconesses Croix Saint-Simon, Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Saint-Antoine [AP-HP], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), CHU Bordeaux [Bordeaux], Composantes innées de la réponse immunitaire et différenciation (CIRID), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Maladies génétiques d'expression pédiatrique (U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie intégrative du tissu osseux, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Service de rhumatologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de Médecine Interne [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de rhumatologie [CH Gustave Dron, Tourcoing], Centre Hospitalier Gustave Dron [Tourcoing], Hopital Réné Dubos, Université Paris 1 Panthéon-Sorbonne - UFR Science Politique (UP1 UFR11), and Université Paris 1 Panthéon-Sorbonne (UP1)

Subjects
medicine.medical_specialty, Immunology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, law, hemic and lymphatic diseases, Internal medicine, Clinical endpoint, Immunology and Allergy, Medicine, 030212 general & internal medicine, 030203 arthritis & rheumatology, business.industry, Hazard ratio, Odds ratio, Articles, medicine.disease, Intensive care unit, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Rheumatoid arthritis, Cohort, Rituximab, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study, medicine.drug
Abstract

Summary Background Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is associated with severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases. Methods In this cohort study, we analysed data from the French RMD COVID-19 cohort, which included patients aged 18 years or older with inflammatory rheumatic and musculoskeletal diseases and highly suspected or confirmed COVID-19. The primary endpoint was the severity of COVID-19 in patients treated with rituximab (rituximab group) compared with patients who did not receive rituximab (no rituximab group). Severe disease was defined as that requiring admission to an intensive care unit or leading to death. Secondary objectives were to analyse deaths and duration of hospital stay. The inverse probability of treatment weighting propensity score method was used to adjust for potential confounding factors (age, sex, arterial hypertension, diabetes, smoking status, body-mass index, interstitial lung disease, cardiovascular diseases, cancer, corticosteroid use, chronic renal failure, and the underlying disease [rheumatoid arthritis vs others]). Odds ratios and hazard ratios and their 95% CIs were calculated as effect size, by dividing the two population mean differences by their SD. This study is registered with ClinicalTrials.gov, NCT04353609. Findings Between April 15, 2020, and Nov 20, 2020, data were collected for 1090 patients (mean age 55·2 years [SD 16·4]); 734 (67%) were female and 356 (33%) were male. Of the 1090 patients, 137 (13%) developed severe COVID-19 and 89 (8%) died. After adjusting for potential confounding factors, severe disease was observed more frequently (effect size 3·26, 95% CI 1·66–6·40, p=0·0006) and the duration of hospital stay was markedly longer (0·62, 0·46–0·85, p=0·0024) in the 63 patients in the rituximab group than in the 1027 patients in the no rituximab group. 13 (21%) of 63 patients in the rituximab group died compared with 76 (7%) of 1027 patients in the no rituximab group, but the adjusted risk of death was not significantly increased in the rituximab group (effect size 1·32, 95% CI 0·55–3·19, p=0·53). Interpretation Rituximab therapy is associated with more severe COVID-19. Rituximab will have to be prescribed with particular caution in patients with inflammatory rheumatic and musculoskeletal diseases. Funding None.

Published
2021

285. HIV-1 Recent Infection Testing Algorithm With Antiretroviral Drug Detection to Improve Accuracy of Incidence Estimates

Author

Voetsch, Andrew C., primary, Duong, Yen T., additional, Stupp, Paul, additional, Saito, Suzue, additional, McCracken, Stephen, additional, Dobbs, Trudy, additional, Winterhalter, Frieda S., additional, Williams, Daniel B., additional, Mengistu, Assegid, additional, Mugurungi, Owen, additional, Chikwanda, Prisca, additional, Musuka, Godfrey, additional, Ndongmo, Clement B., additional, Dlamini, Sindisiwe, additional, Nuwagaba-Biribonwoha, Harriet, additional, Pasipamire, Munyaradzi, additional, Tegbaru, Belete, additional, Eshetu, Frehywot, additional, Biraro, Samuel, additional, Ward, Jennifer, additional, Aibo, Dorothy, additional, Kabala, Andrew, additional, Mgomella, George S., additional, Malewo, Optatus, additional, Mushi, Jeremiah, additional, Payne, Danielle, additional, Mengistu, Yohannes, additional, Asiimwe, Fred, additional, Shang, Judith D., additional, Dokubo, Emily K., additional, Eno, Laura T., additional, Zoung-Kanyi Bissek, Anne-Cécile, additional, Kingwara, Leonard, additional, Junghae, Muthoni, additional, Kiiru, John N., additional, Mwesigwa, Richard C.N., additional, Balachandra, Shirish, additional, Lobognon, Roger, additional, Kampira, Elizabeth, additional, Detorio, Mervi, additional, Yufenyuy, Ernest L., additional, Brown, Kristin, additional, Patel, Hetal K., additional, and Parekh, Bharat S., additional

Published
2021
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286. Abstract 1671: Evaluation of total PD-1 expression using multi-color flow cytometry in metastatic non-small Cell lung cancer patients treated with multi-neoantigen vector (ADXS-503) alone and in combination of pembrolizumab to assess T-cell & T-cell memory subsets

Author

Mohanram, Venkat, primary, Belkina, Natalya, additional, Bisconte, Angelina R., additional, Goldman, Jonathan W., additional, Gerstner, Gregory J., additional, Haigentz, Missak, additional, Stinchcombe, Thomas, additional, Halmos, Balazs, additional, Vangala, Surya, additional, Kabala, Victor, additional, Simkhada, Dinesh, additional, Metran, Cristiane, additional, Davis, Darren, additional, Parsi, Megan, additional, Gutierrez, Andres A., additional, Phippard, Deborah, additional, and Ramalingam, Suresh S., additional

Published
2021
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287. COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Author

Avouac, Jérôme, primary, Drumez, Elodie, additional, Hachulla, Eric, additional, Seror, Raphaèle, additional, Georgin-Lavialle, Sophie, additional, El Mahou, Soumaya, additional, Pertuiset, Edouard, additional, Pham, Thao, additional, Marotte, Hubert, additional, Servettaz, Amélie, additional, Domont, Fanny, additional, Chazerain, Pascal, additional, Devaux, Mathilde, additional, Claudepierre, Pascal, additional, Langlois, Vincent, additional, Mekinian, Arsène, additional, Maria, Alexandre Thibault Jacques, additional, Banneville, Béatrice, additional, Fautrel, Bruno, additional, Pouchot, Jacques, additional, Thomas, Thierry, additional, Flipo, René-Marc, additional, Richez, Christophe, additional, Aeschlimann, Florence, additional, Agard, Christian, additional, Ait-Abdallah, Nassim, additional, Albert, Jean-David, additional, Alcais, Didier, additional, Allain, Jean-Sébastien, additional, Allanore, Yannick, additional, Amador-Borreiro, Blanca, additional, Amoura, Zahir, additional, Andre, Emma, additional, Arbault, Anaïs, additional, Arlet, Jean-Benoît, additional, Arnaud, Laurent, additional, Arniaud, Denis, additional, Arty-Hue, Herliette, additional, Atlan, Lucie, additional, Audemard-Verger, Alexandra, additional, Audoin-Pajot, Christine, additional, Audren, Victor, additional, Bach-Bunner, Maxime, additional, Bacquet-Deschryver, Hélène, additional, Bader-Meunier, Brigitte, additional, Balandraud, Nathalie, additional, Balblanc, Jean-Charles, additional, Bally, Stéphane, additional, Banal, Frédéric, additional, Barbery, Pierre, additional, Barnetche, Thomas, additional, Barrelet, Audre, additional, Basch, André, additional, Baumier, Vincent, additional, Bayer, Guillaume, additional, Bayle, Sophie, additional, Beauvais, Catherine, additional, Beinat, Rudie, additional, Belin, Véronique, additional, Belkhir, Rakiba, additional, Benainous, Ruben, additional, Belot, Alexandre, additional, Benammar, Mohammed, additional, Benhamou, Mathilde, additional, Benhamou, Ygal, additional, Benmansour, Ahmed, additional, Bennet, Pascal, additional, Bernoux-Manat, Brigitte, additional, Berthet, Elise, additional, Berthoux, Emilie, additional, Bertolini, Ewa, additional, Bigot, Adrien, additional, Bisson-Vaivre, Aurélia, additional, Blaison, Gilles, additional, Bolla, Gilles, additional, Bonidan, Olivier, additional, Bonnet, Christine, additional, Borie, Raphaël, additional, Bossert, Marie, additional, Boudou, Laurence, additional, Bouhour, Françoise, additional, Bouiller, Kévin, additional, Bouldoires, Bastien, additional, Boussoualim, Karima, additional, Bouvard, Eric, additional, Brondino, Regine, additional, Buchlin, Pierre, additional, Cabantous, Laurence, additional, Cacoub, Patrice, additional, Cadiou, Simon, additional, Carteni, Maurizio, additional, Carbasse, Aurélia, additional, Castel, Brice, additional, Cathebras, Pascal, additional, Caumont, Hervé, additional, Celant, Annalisa, additional, Chaigne, Benjamin, additional, Chaillous, Benoît, additional, Champy, Romuald, additional, Charcot, Agnès, additional, Charles, Pierre, additional, Charlot-Lambrecht, Isabelle, additional, Charpin, Caroline, additional, Chatelus, Emmanuel, additional, Chaudier, Bernard, additional, Chertok, Pascale, additional, Chevalier, Xavier, additional, Chevreau, Maxime, additional, Chotard, Emilie, additional, Chu Miow Lin, Delphine, additional, Clavel, Gaëlle, additional, Clavel-Osorio, Cyril, additional, Cohen, Fleur, additional, Cohen, Gregory, additional, Colette-Cedoz, Marie-Eve, additional, Collercandy, Nived, additional, Colombey, Antoine, additional, Comarmond, Chloé, additional, Combe, Bernard, additional, Comparon, Céline, additional, Constant, Elodie, additional, Coquerelle, Pascal, additional, Corli, Justine, additional, Corre, Clémence, additional, Costedoat-Chalumeau, Nathalie, additional, Couret, Marie, additional, Courvoisier, Natacha, additional, Coury-Lucas, Fabienne, additional, Coutarel, Cécile, additional, Coutier, Fabrice, additional, Damade, Richard, additional, Daver-Malaterre, Laurence, additional, Dehimat, Sarahe, additional, Delahousse, Michel, additional, Barrois-Delattre, Emilie, additional, Denarie, Delphine, additional, Deprouw, Camille, additional, Dernis, Emanuelle, additional, Deroux, Alban, additional, Desbarbieux, Renaud, additional, Descamps, Elise, additional, Deslandre, Chantal, additional, Desmurs, Marie, additional, Despaux, Jacques, additional, Desplats, Marie, additional, Detree, Frédérick, additional, Devauchelle-Pensec, Valérie, additional, Dhote, Robin, additional, Dieude, Philippe, additional, Dieudonne, Yannick, additional, Diot, Elisabeth, additional, Direz, Guillaume, additional, Djeddi, Djamal-Dine, additional, Douvier, Sarah, additional, Drouet, Béatrice, additional, Duc, Catherine, additional, Ducornet, Angélique, additional, Dufauret-Lombard, Carine, additional, Duhamel, Alain, additional, Dumaine, Cécile, additional, Dumel, Anne-Elisabeth, additional, Dumoulin-Richez, Chantal, additional, Duquesne, Agnès, additional, Durand, Géraldine, additional, Durandin-Truffinet, Mariane, additional, Duret, Pierre-Marie, additional, Duval, Maïka, additional, Ebbo, Mikaël, additional, Ebstein, Esther, additional, Economu-Dubosc, Andra, additional, Emilie, Stéphanie, additional, Euvrard, Romain, additional, Evon, Philippe, additional, Fabre, Sylvie, additional, Fagedet, Dorothée, additional, Farhat, Meryem, additional, Fauconier, Marion, additional, Fechtenbaum, Jacques, additional, Felten, Renaud, additional, Fernandes, Fanny, additional, Ferreira-Maldent, Nicole, additional, Feurer, Elodie, additional, Fichet, Amandine, additional, Flaisler, Françoise, additional, Florens, Nans, additional, Foltz, Violaine, additional, Fontanges, Elisabeth, additional, Foret, Jennifer, additional, Fougerousse, Anne-Claire, additional, Fouque-Aubert, Anne, additional, Foutrier-Morello, Catherine, additional, Francois-Pradier, Hélène, additional, Frantzen, Léa, additional, Fritz, Pierre, additional, Froissart, Antoine, additional, Fulpin, Jean, additional, Fuzibet, Piera, additional, Gaches, Francis, additional, Gagneux-Lemoussu, Laurence, additional, Penhoat-Gahier, Mélanie, additional, Galland, Joris, additional, Gandjbakhch, Frédérique, additional, Garnier, Nicole, additional, Garraud, Thomas, additional, Garrot, Jean-François, additional, Gastaldi, Romain, additional, Gaud-Listrat, Véronique, additional, Gauthier-Prieur, Maud, additional, Georgescu, Dana, additional, Gerard, Nathalie, additional, Gervais, Elisabeth, additional, Gibert, Christelle, additional, Gibert, Eric, additional, Gill, Ghislaine, additional, Gillard, Jérôme, additional, Gilson, Mélanie, additional, Gimonnet, Pauline, additional, Giraudet-Le Quintrec, Jeanine-Sophie, additional, Giraud-Morelet, Aude, additional, Glace, Baptiste, additional, Glanowski, Camille, additional, Godeau, Bertrand, additional, Gombert, Bruno, additional, Gonnet-Gracia, Camille, additional, Goulenok, Tiphaine, additional, Goupille, Philippe, additional, Gourmelen, Olivier, additional, Govindaraju-Audouard, Sophie, additional, Grados, Franck, additional, Grall-Lerosey, Martine, additional, Grardel, Bruno, additional, Grasland, Anne, additional, Grateau, Gilles, additional, Groza, Monica, additional, Guillaud, Constance, additional, Guillaume, Séverine, additional, Guillibert, Caroline, additional, Guillot, Xavier, additional, Guilpain, Philippe, additional, Gury, Aline, additional, Guyot, Marie-Hélène, additional, Hacquard-Bouder, Cécile, additional, Havard, Marie-Noelle, additional, Hellier, Jean-Pierre, additional, Hennequin, Pascal, additional, Henriot, Basile, additional, Henry, Julien, additional, Hentgen, Véronique, additional, Hermet, Marion, additional, Herasse, Muriel, additional, Hernandez, Julie, additional, Hie, Miguel, additional, Hilliquin, Pascal, additional, Hinschberger, Olivier, additional, Hittinger-Roux, Ambre, additional, Holubar, Jan, additional, Hudry, Christophe, additional, Huguenel, Serge, additional, Jaccard, Clara, additional, Jacquemier, Jean-Michel,, additional, Jamard, Bénédicte, additional, Jan, Catherine, additional, Jean, Sylvie, additional, Jouvray, Mathieu, additional, Juge, Pierre-Antoine, additional, Juillard, Laurent, additional, Jullien, Denis, additional, Kabala, Anna, additional, Kabchou, Abdelkrim, additional, Karkowski, Ludovic, additional, Karman, Françoise, additional, Kemiche, Farid, additional, Keraen, Jérémy, additional, Kieffer, Pierre, additional, Kone-Paut, Isabelle, additional, Koreichi, Abdeldajallil, additional, Kostine, Marie, additional, La Batide Alanore, Sylvain, additional, Lafforgue, Pierre, additional, Lahalle, Sophie, additional, Lambert, Marc, additional, Lambrecht, Isabelle, additional, Lanot, Sylvain, additional, Lanteri, Aurélia, additional, Larbre, Jean-Paul, additional, Latourte, Augustin, additional, Lavigne, Christian, additional, Le Guen Guegan, Sophie, additional, Le Guenno, Guillaume,, additional, Leguy, Diane, additional, Lebrun, Agnès, additional, Ledoult, Emmanuel, additional, Legoupil, Nathalie, additional, Legrand, Erick, additional, Lejeune, Charlotte, additional, Leloire, Olivier, additional, Leroux, Christophe, additional, Leroy, Rémi, additional, Leroy-Gouix, Marie, additional, Leturcq, Tifenn, additional, Leurs, Amélie, additional, Leveque-Michaud, Céline, additional, Limbach, François-Xavier, additional, Liote, Frédéric, additional, Lohse, Anne, additional, Lozac'h, Pierre, additional, Lucas, Virginie, additional, Madelon, Aurélie, additional, Magy-Bertrand, Nadine, additional, Mahevas, Matthieu, additional, Maillard, Hélène, additional, Maillet, Thibault, additional, Malochet-Guinamand, Sandrine, additional, Mangon, Quentin, additional, Marchou-Lopez, Sylvie, additional, Margarit, Nathalie, additional, Marhadour, Thierry, additional, Mariette, Xavier, additional, Martin, Claire, additional, Mathian, Alexis, additional, Maurier, François, additional, Maury, Frédéric, additional, Mazet-Guillaume, Betty, additional, Mazouyez, Arnaud, additional, Mazyad, Hassan, additional, Mehsen-Cetre, Nadia, additional, Meinzer, Ulrich, additional, Melki, Isabelle, additional, Messer, Laurent, additional, Miceli, Corinne, additional, Michaud, Martin, additional, Michel, Catherine, additional, Michel, Matthias, additional, Michon, Mathilde, additional, Milesi-Lecat, Anne-Marie, additional, Molto, Anna, additional, Moly, Marie, additional, Moranne, Olivier, additional, Morel, Gautier, additional, Morel, Hugo, additional, Morel, Jacques, additional, Morin, Franck, additional, Moulinier, Laurence, additional, Moulis, Guillaume, additional, Moura, Bertrand, additional, Nguyen, Minh, additional, Nicolas-Vullierme, Sabine, additional, Nielly, Hubert, additional, Nocturne, Gaétane, additional, Nottez, Aurore, additional, Ollagnon, Henri-Olivier, additional, Pacaud-Vitoux, Isabelle, additional, Pagnier, Anne, additional, Paris, Caroline, additional, Parrot, Antoine, additional, Pascart, Tristan, additional, Pascaud-Mansour, Yasmina, additional, Paulin, Lætitia, additional, Pavy, Stephan, additional, Perard, Laurent, additional, Pers, Yves-Marie, additional, Pha, Micheline, additional, Pichon, Maud, additional, Pierreisnard, Audrey, additional, Pizana, Gabrielle, additional, Poignant, Sylvaine, additional, Poix, Elsa, additional, Portier, Agnès, additional, Poulet, Antoine, additional, Plassard, Samira, additional, Pugnet, Grégory, additional, Puyraimond-Zemmour, Déborah, additional, Quartier-Dit-Maire, Pierre, additional, Quenet, Marion, additional, Queyrel, Viviane, additional, Raffray, Loïc, additional, Remy, Philippe, additional, Renard, Myriam, additional, Rene, Jessica, additional, Revuz, Sabine, additional, Rey, Bénédicte, additional, Richard-Colmant, Gaëlle, additional, Riviere, Etienne, additional, Riviere, Sébastien, additional, Robin, Sophie, additional, Rohmer, Julien, additional, Roitg, Isabelle, additional, Romier, Mélanie, additional, Rolland, Michel, additional, Roriz, Mélanie, additional, Rosenberg, Carole, additional, Rossi, Linda, additional, Roth, Olivier, additional, Rouidi, Sid-Ahmed, additional, Roumier, Mathilde, additional, Rousiere, Mickaël, additional, Rousselin, Clémentine, additional, Rouviere, Bénédicte, additional, Roux, Christian, additional, Roux, Fabienne, additional, Roux, Marielle, additional, Roux, Nicolas, additional, Rouzaud, Diane, additional, Rozenberg, Sylvie, additional, Sacco, Isabelle, additional, Sadji, Fatiha, additional, Sailler, Laurent, additional, Salliot, Carine, additional, Salmon, Jean-Hugues, additional, Saraux, Alain, additional, Schmidt, Jean, additional, Seguier, Julie, additional, Sellam, Jérémie, additional, Senbel, Eric, additional, Sene, Thomas, additional, Senet, Patricia, additional, Seve, Pascal, additional, Sicaud, Aurélie, additional, Smets, Perrine, additional, Sobanski, Vincent, additional, Sordet, Christelle, additional, Sornay-Rendu, Elisabeth, additional, Souchaud-Debouverie, Odile, additional, Sparsa, Lætitia, additional, Spielmann, Lionel, additional, Steib, Sarah, additional, Stavris, Chloé, additional, Straus, Catherine, additional, Strotz, Victor, additional, Szafors, Paulina, additional, Taffignon-Clave, Séverine, additional, Simoens, Justine, additional, Theillac, Claire, additional, Tenenbaum, Nora, additional, Thomachot, Benoît, additional, Tieulie, Nathalie, additional, Tiriau, Soizic, additional, Tison, Alice, additional, Toussirot, Eric, additional, Trefond, Ludovic, additional, Trijau, Sophie, additional, Trouillier, Sébastien, additional, Trouvin, Anne-Priscille, additional, Truchetet, Marie-Elise, additional, Ulrich, Marc, additional, Vaquier, Jacques, additional, Veillard, Eric, additional, Veillon, Laurent, additional, Vial, Guillaume, additional, Viallard, Jean-François, additional, Victor, Judith, additional, Vidon, Claire, additional, Vidon, Mathias, additional, Vigne, Camille, additional, Virone, Alexandre, additional, Warzocha, Ursula, additional, Wendling, Daniel, additional, Werle, Claude, additional, Wibaux, Cécile, additional, Willems, Alexandra, additional, Wisniewski, Michel, additional, Woessner, Juliette, additional, and Xerri-Campano, Bernadette, additional

Published
2021
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290. Editors’ Introduction

Author

Boleslaw Z. Kabala, Ashleen Menchaca-Bagnulo, and Nathan Pinkoski

Published
2021

291. Heparanase Inhibition Prevents Liver Steatosis in E0 Mice

Author

Rawan Hammoud, Hisam Zaidani, Lana Mansour-Wattad, Walaa Hijaze, Safa Kinaneh, Aviva Kabala, and Shadi Hamoud

Subjects
medicine.medical_specialty, business.industry, Cholesterol, heparanase, PG545, SST0001, liver steatosis, E0 mice, Fatty liver, Lipid metabolism, General Medicine, medicine.disease, chemistry.chemical_compound, Endocrinology, chemistry, In vivo, Internal medicine, Lipogenesis, Medicine, Lipolysis, Heparanase, Steatosis, business
Abstract

Non-alcoholic fatty liver disease affects up to 30% of adults in USA, and is associated with higher incidence of chronic liver morbidity and mortality. Several molecular pathways are involved in the pathology of liver steatosis including lipid uptake, lipogenesis, lipolysis, and beta-oxidation. The enzyme heparanase has been implicated in liver steatosis. Herein, we investigated the effect of heparanase inhibition on liver steatosis in E 0 mice. Methods: In vivo experiments: Male wild type mice fed with either chow diet (n=4) or high fat diet (n=6), and male E 0 mice fed with chow diet (n=8) or high fat diet (n=33) were included. Mice on high fat diet were treated for 12 weeks with PG545 at low dose (6.4 mg/kg/week, ip, n=6) or high dose (13.3 mg/kg/week, ip, n=7), SST0001 (1.2 mg/mouse/day, ip, n=6), or normal saline (control, n=14). Animals were sacrificed two days after inducing peritonitis. Serum was analyzed for biochemical parameters. Mouse peritoneal macrophages (MPMs) were harvested and analyzed for lipid content. Livers were harvested for histopathological analysis of steatosis, lipid content, and the expression of steatosis-related factors at mRNA level.In vitro experiments: MPMs were isolated from untreated E 0 mice aged 8-10 weeks, and were cultured and treated with either PG545 or SST0001 both at 50 µg/ml for 24 hours, followed by assessment of mRNA expression of steatosis related factors.Results: Heparanase inhibition significantly attenuated the development of liver steatosis as was evident by liver histology and lipid content. Serum analysis indicated lowering of cholesterol and triglycerides levels in mice treated with heparanase inhibitors. In liver tissue, assessment of mRNA expression of key factors in lipid uptake, lipolysis, lipogenesis and beta-oxidation exhibited significant downregulation following PG545 treatment and to a lesser extent when SST0001 was applied. However, in-vitro treatment of MPMs with PG545, but not SST0001, resulted in increased lipid content in these cells, which is opposed to their effect on MPMs of treated mice. This may indicate distinct regulation pathways in system or isolated macrophages following heparanase inhibition. Conclusion: Heparanase inhibition significantly attenuates the development of liver steatosis by decreasing tissue lipid content and by affecting the mRNA expression of key lipid metabolism regulators. Funding Information: None to declare. Declaration of Interests: None to declare. Ethics Approval Statement: The study was conducted according to the National Institutes of Health guidelines and was approved by the Technion Ethics Committee for Experimentation in Animals- ethics number IL1090717.

Published
2021

292. Energy Access Assessment of Pakistan

Author

Randy Matuka Kabala, Anges Akim Aminou Moussavou, and M Adonis

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2021

293. Comparison of the Mechanical Properties of Adhesively Bonded and Mechanically Interlocked Steel/Fibre-Reinforced Thermoplastic Hybrids Produced Using One-Step Forming Process

Author

David Trudel-Boucher, Jan Beuscher, Klaus Dröder, Michel F. Champagne, and Philipp Kabala

Subjects
chemistry.chemical_classification, Thermoplastic, Fabrication, Materials science, chemistry, Fuel efficiency, Forming processes, One-Step, Adhesive, Composite material, Blank, Interlocking
Abstract

The continuous increase in the weight of newly registered vehicles is in conflict with the targeted reduction in greenhouse gases emission and fuel consumption imposed by several environmental regulations. To meet these stringent environmental regulations, the fabrication of hybrid structural parts is a particularly suitable alternative for mass-produced vehicles. Through the combination of fibre-reinforced thermoplastics (FRTP’s) and steels, an optimum of component costs and weight savings can potentially be achieved. However, the production of hybrid components traditionally involves additional manufacturing steps and a subsequent joining processes. In order to increase the efficiency of the hybrid production process, both materials can be formed and joined together in one forming step. In this paper, two different approaches to join FRTP and steel sheet in a single forming step are compared in respect of their mechanical strength. For this, structured steel sheets designed to obtain mechanical interlocking and an adhesive film are used. Furthermore, process parameters such as forming force, blank holder force and tool temperature are varied during the manufacturing process to determine their influence on the mechanical performance.

Published
2021

294. Tempered fractionally integrated process with stable noise as a transient anomalous diffusion model

Author

Farzad Sabzikar, Jinu Kabala, and Krzysztof Burnecki

Subjects
Statistics and Probability, Modeling and Simulation, General Physics and Astronomy, Statistical and Nonlinear Physics, Mathematical Physics
Abstract

We present here the autoregressive tempered fractionally integrated moving average (ARTFIMA) process obtained by taking the tempered fractional difference operator of the non-Gaussian stable noise. The tempering parameter makes the ARTFIMA process stationary for a wider range of the memory parameter values than for the classical autoregressive fractionally integrated moving average, and leads to semi-long range dependence and transient anomalous behavior. We investigate ARTFIMA dependence structure with stable noise and construct Whittle estimators. We also introduce the stable Yaglom noise as a continuous version of the ARTFIMA model with stable noise. Finally, we illustrate the usefulness of the ARTFIMA process on a trajectory from the Golding and Cox experiment.

Published
2022

297. A phase 1 study of an off-the shelf, multi-neoantigen vector (ADXS-503) in subjects with metastatic non-small cell lung cancer (NSCLC) progressing on pembrolizumab as last therapy.

Author

Haigentz, Missak, primary, Ramalingam, Suresh S., additional, Gerstner, Gregory James, additional, Halmos, Balazs, additional, Morganstein, Neil, additional, Vangala, Surya, additional, Parsi, Megan, additional, Kabala, Victor, additional, Simkhada, Dinesh, additional, Metran, Cristiane, additional, GUTIERREZ, ANDRES A., additional, and Goldman, Jonathan Wade, additional

Published
2021
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298. Rotary Telemetry System for Temperature Measurements in Aircraft Component Testing.

Author

Kabala, Tomasz and Weremczuk, Jerzy

Subjects
*TELEMETRY, *TEMPERATURE measurements, *INTELLIGENT sensors, *AIRPLANE motors, *AERONAUTICS
Abstract

Aviation testing is intrinsically connected with rotary telemetry, which enables engineers to measure and verify parameters of high-speed aircraft engines components during laboratory testing. The main purpose of this article is to propose new design concept of smart telemetry module for temperature measurements, which could be easily adapted to various demands of high-speed rotary components tests and is more handful, functional and affordable than other solutions on the market. The result of the work is a telemetry system in form of light weight, PCB-based, wireless powered, smart transducer. Article presents state of art analysis, design and manufacturing steps, test results and conclusions. [ABSTRACT FROM AUTHOR]

Published
2022
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