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The efficacy of surgery in combination of chemotherapy for stage IIIA small cell lung cancer (IIIA-SCLC) is controversial. The aim of the present study was to analyze the efficacy of surgery combined with chemotherapy, especially in the setting of neoadjuvant chemotherapy (NAC) followed by surgery for IIIA-SCLC.Between 2004 and 2015, we reviewed 2,199 chemotherapy-treated stage IIIA (N1/2) SCLC cases in the Surveillance, Epidemiology, and End Results (SEER) database, and 32 NAC + intentional radical resection-treated, centrally-located IIIA-SCLC cases at Shanghai Pulmonary Hospital (SPH). Outcomes were compared between surgically and non-surgically treated patients from the SEER database after propensity score matching (PSM), and comparing lobectomy/bi-lobectomy and pneumonectomy patients from SPH. Prognostic factors were evaluated by Kaplan-Meier method and the Cox proportional hazards regression model.There was significantly higher overall survival (OS) in surgically treated IIIA-SCLC patients (OS, 44.8For stage IIIA SCLC patients, complete resection combined with chemotherapy might improve the prognosis than patients without surgery. Post-NAC lobectomy was not found to be superior to sub-lobectomy, while pneumonectomy was considered suitable for central-type IIIA-SCLC patients after NAC treatment.

This retrospective study aimed to compare the performance of contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) in staging surgically treated early-stage cervical cancer.Patients with surgically treated cervical carcinoma confirmed by post-operative pathological findings were included between December 2016 and December 2018. All included patients underwent both CEUS and MRI examinations before the surgery. Post-operative pathology was used as the gold standard. The κ values were calculated to assess the agreements of CEUS and MRI in staging cervical carcinoma in comparison with post-operative pathology.Complete data were available for 39 patients. CEUS showed great inter-observer reproducibility in tumor measurement [Intra-class Correlation Coefficient (ICC) 0.831] and moderate inter-observer reproducibility in the evaluation of vaginal infiltration and parametrial invasion (Cohen's κ 0.692 and 0.624). Tumor size was comparable as measured by CEUS and MRI (ICC 0.769). Both CEUS and MRI presented good concordance with post-operative pathology in staging cervical cancer (weighted κ 0.732 and 0.761).CEUS was comparable to MRI in staging surgically treated cervical cancer and might be considered in the pre-treatment work-up for cervical cancer.

Cuproptosis is a newfound cell death form that depends on copper (Cu) ionophores to transport Cu into cancer cells. Studies on the relationship have covered most common cancer types and analyzed the links between cuproptosis-related genes (CRGs) and various aspects of tumor characteristics. In this study, we evaluated the role of cuproptosis in lung adenocarcinoma (LUAD) and constructed the cuproptosis-related score (CuS) to predict aggressiveness and prognosis in LUAD, so as to achieve precise treatment for patients. CuS had a better predictive performance than cuproptosis genes, possibly due to the synergy of SLC family genes, and patients with a high CuS had a poor prognosis. Functional enrichment analysis revealed the correlation between CuS and immune and mitochondrial pathways in multiple datasets. Furthermore, we predicted six potential drugs targeting high-CuS patients, including AZD3759, which is a targeted drug for LUAD. In conclusion, cuproptosis is involved in LUAD aggressiveness, and CuS can accurately predict the prognosis of patients. These findings provide a basis for precise treatment of patients with high CuS in LUAD.

Background The safety and efficacy of rotational atherectomy (RA) in acute coronary syndrome (ACS) patients treated with different rotational speeds remain unclear.Methods This was an observational retrospective registry. Between February 2017 and January 2022, a total of 283 ACS patients were treated with RA. The patients were divided into two groups: the low-speed group (130,000-150,000rpm,182 cases) and the high-speed group (160,000-220,000rpm,101 cases) according to the maximum RA speed. The primary outcome was the occurrence of hypotension, vasospasm, dissection, slow flow, perforation, bradyarrhythmia, burr entrapment, rotawire fracture during RA, as well as the incidence of heart failure, stent thrombosis, and cardiac death during hospitalization.Results Patients in the low-speed RA group experienced a higher incidence of vasospasm during RA operation (15.4% versus 6.9%, p = 0.040), whereas the incidence of slow blood flow was higher in the high-speed RA group (16.5% versus 27.7%, p = 0.031). There was no significant difference in other complications between the two groups. Moreover, logistic regression analysis identified rotational speed (160,000-220,000rpm) as a predictor of slow flow during RA operation (OR = 1.900, 95%CI:1.006–3.588, p = 0.048). For every 10,000 rpm increase in rotational speed, the risk of slow flow increased by 27% (OR = 1.273, 95% CI: 1.047–1.547, p = 0.015).Conclusion ACS patients treated with a lower RA speed (130,000-150,000 rpm) had a higher risk of vasospasm, while in patients where higher speeds were used (160,000-220,000 rpm ), a higher incidence of slow flow was identified. High rotational speed (160,000-220,000 rpm) is an independent risk factor for slow flow during RA in ACS patients.

Due to the advantages of large workspace, low cost and the integrated vision/force sensing, robotic milling has become an important way for machining of complex parts. In recent years, many scholars have studied the problems existing in the applications of robotic milling, and lots of results have been made in the dynamics, pose planning, deformation control etc., which provides theoretical guidance for high precision and high efficiency of robotic milling. From the perspective of complex parts robotic milling, this paper focuses on machining process planning and control techniques including the analysis of the robot-workspace, robot trajectory planning, vibration monitoring and control, deformation monitoring and compensation. As well as the principles of these technologies such as robot stiffness characteristics, dynamic characteristics, chatter mechanisms, and deformation mechanisms. The methods and characteristics related to the theory and technology of robotic milling of complex parts are summarized systematically. The latest research progress and achievements in the relevant fields are reviewed. It is hoped that the challenges, strategies and development related to robotic milling could be clarified through the carding work in this paper, so as to promote the application of related theories and technologies in high efficiency and precision intelligent milling with robot for complex parts.

Parkinson’s disease (PD) is an incurable neurodegenerative disease characterized by aggregation of pathological alpha-synuclein (α-syn) and loss of dopaminergic neuron in the substantia nigra. Inhibition of phosphorylation of the α-syn has been shown to mediate alleviation of PD-related pathology. Protein phosphatase 2A (PP2A), an important serine/threonine phosphatase, plays an essential role in catalyzing dephosphorylation of the α-syn. Here, we identified and validated cancerous inhibitor of PP2A (CIP2A), as a potential diagnostic biomarker for PD. Our data showed that plasma CIP2A concentrations in PD patients were significantly lower compared to age- and sex-matched controls, 1.721 (1.435–2.428) ng/ml vs 3.051(2.36–5.475) ng/ml, p

Isotropic β-Bi2O3 with high charge-carrier mobility was demonstrated for the efficient degradation of bisphenol A and phenol under sunlight irradiation.

Potential release pathways, environmental transformations and health risks of QDs.

Nanosheets loading on tetrahedral surfaces of a Bi2MoO6/γ-Bi2O3 heterojunction forming a Z-type energy band to enhance the photocatalytic degradation activity.

Neural tissue engineering has been introduced as a novel therapeutic strategy for trauma-induced sciatic nerve defects. Here, we report a neuropeptide S (NPS)-crosslinked fibrin scaffolds (NPS@Fg) loaded with an ectomesenchymal stem cell (EMSC) system to bridge an 8-mm sciatic nerve defect in rats. The Schwann cell-like and neural differentiation of the EMSCs on the engineered fibrin scaffolds were also assessed in vitro. Our results showed that the NPS@Fg promoted the differentiation of EMSCs into neuronal lineage cells, which may also contribute to the therapeutic outcome of the NPS@Fg+EMSCs strategy. After transplantation NPS@Fg+EMSCs into sciatic nerve defects in rats, nerve recovery was assessed up to 12 weeks postinjury. In vivo experiments showed that the combination of NPS crosslinked fibrin scaffolds with EMSCs could significantly accelerate nerve healing and improve morphological repair. In the study, NPS@Fg+EMSCs may represent a new potential strategy for peripheral nerve reconstruction. This article is protected by copyright. All rights reserved.

Rotation welding of wood dowels has the advantages of high bonding strength, fast processing speed and green environmental protection, and is suitable for jointing nodes in furniture and wood products. However, most wood friction welding specimens have poor water resistance where the welded joints are more likely to be damaged in wet environments, which greatly limits their wider application. Previous studies focused on using natural and green materials or methods to enhance bonding strength and water resistance of friction-welded joints. This paper reveals an innovative chemical pretreatment method to improve the water resistance of rotary friction welded joints by treating the substrate blocks or dowels with reagents that successively oxidize and sulfonate the wood, and spraying the dowels with Zinc acetate alcohol solution that has a lubricant effect, followed by friction welding. The findings show that both the dry bonding strength of friction welded joints and the wet bonding strength after impregnation with cold, hot, and boiling water of dowels pretreated with oxidation and sulfonation reactions were higher than those without pretreatment and significantly superior to the traditional polyvinyl acetate (PVAc) adhesive bonding.

Recent research has shown that jellyfish blooms occur more frequently near nuclear power plants (NPPs), and a relationship between thermal discharges from the NPPs and the blooms has been hypothesized. There is, however, no direct evidence that links the thermal discharges with jellyfish blooms. In this study, we conducted 3 cruises (pre-bloom, bloom, and post-bloom) during July to September 2017 in the area surrounding the largest NPP in northern China. The water temperature near the cooling water outfall rose by 2 °C. Although we found no significant impact on phytoplankton abundance or community composition near the outfall, a broader analysis of monitoring data revealed significant correlations between temperature and the abundance of Nemopilema nomurai , cyanobacteria, and haptophytes. Temperature increases may have a stimulatory effect on key stages in the life history of jellyfish, and the abundance of jellyfish prey may be the factor that triggers jellyfish blooms. Blooms of jellyfish were accompanied by a decline of diatom dominance and an increase of the concentrations of small phytoplankton such as cyanobacteria and haptophytes. This study revealed for the first time a significant positive correlation ( R 2 = 0.39, P < 0.001) between jellyfish abundance and concentrations of dissolved organic nutrients. This correlation suggested that the blooms of jellyfish resulted in the release of large amounts of organic nutrients. The results provided a comprehensive perspective and suggested a need for further study of the dynamics of planktonic ecosystems to link thermal discharges and jellyfish blooms.

Lead acetate (PbAc2) offers exceptional advantages as lead (Pb2+) source for solution processing of homogeneous and pinholes-free MAPbX3 perovskite films over large areas at low temperatures for photovoltaic applications. However, PbAc2-derived MAPbI3 films usually exhibit small crystallites (

The Yingxiong Range is the largest anticlinal belt within the triangular overlapping zone between the Altyn Tagh Fault and the Eastern Kunlun Fault and thus records the critical information concern...

PURPOSE: To describe the results of a relifting flap enhancement procedure for correction of residual refractive error after primary lenticule intrastromal keratoplasty (LIKE). METHODS: Case report. RESULTS: One year after a LIKE procedure in the left eye, the patient (uncorrected distance visual acuity [UDVA]: 20/25; corrected distance visual acuity [CDVA]: 20/20; manifest refraction: −1.00 +1.00 × 105°) underwent flap relifting. The WaveLight EX500 excimer laser platform (Alcon Laboratories, Inc) was used for the topography-guided enhancement procedure to correct the residual refractive error and corneal irregularities. During the 1-year follow-up period, the cornea remained clear, the UDVA increased to 20/20 (reaching the level of preoperative CDVA), and manifest refraction was −0.25 +0.75 × 90°. CONCLUSIONS: The enhancement procedure described in this case report was effective for correction of residual refractive error and improvement of visual acuity following the LIKE procedure. The enhancement was stable for at least 15 months after the procedure. [ J Refract Surg . 2021;37(10):715–719.]

BackgroundThe liver is an important organ that undertakes the metabolic function of the human body. Liver cancer has become one of the cancers with the highest mortality. In clinic, it is an important work to extract the liver region accurately before the diagnosis and treatment of liver lesions. However, manual liver segmentation is a time-consuming and boring process. Not only that, but the segmentation results usually varies from person to person due to different work experience. In order to assist in clinical automatic liver segmentation, this paper proposes a U-shaped network with multi-scale attention mechanism for liver organ segmentation in CT images, which is called MSA-UNet. Our method makes a new design of U-Net encoder, decoder, skip connection, and context transition structure. These structures greatly enhance the feature extraction ability of encoder and the efficiency of decoder to recover spatial location information. We have designed many experiments on publicly available datasets to show the effectiveness of MSA-UNet. Compared with some other advanced segmentation methods, MSA-UNet finally achieved the best segmentation effect, reaching 98.00% dice similarity coefficient (DSC) and 96.08% intersection over union (IOU).

The cooling of the motor is one of key factors of keeping higher running efficiency of the refrigeration compressor. Suction refrigerant gas cooling motor is a widely used cooling method but it has poor cooling effect. A novel method of directly cooling screw compressor motor by thermosyphon refrigerant was proposed by authors. In this paper, the refrigeration system with thermosyphon refrigerant cooling motor (RSTRCM) and its basic principle were introduced firstly, then the mathematical model of energy and exergy of the system was built, and the test loop of an NH3/CO2 cascade refrigeration system was set up. Finally, compared with the refrigeration system with compressor suction gas cooling motor (RSCSCM), numerical analysis results showed that as condensation temperature of LTL is 5°C, RSTRCM can get higher exergy efficiency by up to 23.53%, and if condensing temperature of LTL increases from -5°C to 5°C, the power consumption of CO2 compressor and NH3 compressor in RSTRCM were reduced by 4.26% and 5.46% on average, separately. The test results showed that as the condensing temperature of the system is 40°C and the evaporation temperature is -45°C, -35°C, and -30°C, the coefficient of performance (COP) of RSTRCM were higher than that of RSCSCM by 10.42%, 6.61%, and 6.25%, respectively, which verify that the method of thermosyphon refrigerant cooling compressor motors can significantly improve the performance of the NH3/CO2 cascade refrigeration system.

Membrane curvature plays important roles in various essential processes of cells, such as cell migration, cell division, and vesicle trafficking. It is not only passively generated by cellular activities, but also actively regulates protein interactions and is involved in many intracellular signaling. Thus, it is of great value to examine the role of membrane curvature in regulating the distribution and dynamics of proteins and lipids. Recently, many techniques have been developed to study the relationship between the curved membrane and protein in vitro. Compared to traditional techniques, the newly developed nanobar-supported lipid bilayer (SLB) offers both high-throughput and better accuracy in membrane curvature generation by forming a continuous lipid bilayer on patterned arrays of nanobars with a pre-defined membrane curvature and local flat control. Both the lipid fluidity and protein sensitivity to curved membranes can be quantitatively characterized using fluorescence microscopy imaging. Here, a detailed procedure on how to form a SLB on fabricated glass surfaces containing nanobar arrays and the characterization of curvature-sensitive proteins on such SLB are introduced. In addition, protocols for nanochip reusing and image processing are covered. Beyond the nanobar-SLB, this protocol is readily applicable to all types of nanostructured glass chips for curvature sensing studies.

Background Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resistance. Methods RNA-seq analysis was applied to five paired progressive disease (PD) and complete response (CR) NPC tissues. Loss-and gain-of-function assays were used for oncogenic function of FLI1 both in vitro and in vivo. RNA-seq analysis, ChIP assays and dual luciferase reporter assays were performed to explore the interaction between FLI1 and TIE1. Gene expression with clinical information from tissue microarray of NPC were analyzed for associations between FLI1/TIE1 expression and NPC prognosis. Results FLI1 is a potential radiosensitivity regulator which was dramatically overexpressed in the patients with PD to radiotherapy compared to those with CR. FLI1 induced radiotherapy resistance and enhanced the ability of DNA damage repair in vitro, and promoted radiotherapy resistance in vivo. Mechanistic investigations showed that FLI1 upregulated the transcription of TIE1 by binding to its promoter, thus activated the PI3K/AKT signaling pathway. A decrease in TIE1 expression restored radiosensitivity of NPC cells. Furthermore, NPC patients with high levels of FLI1 and TIE1 were correlated with poor prognosis. Conclusion Our study has revealed that FLI1 regulates radiotherapy resistance of NPC through TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.

In recent years, as a flexible electrode material, melamine foam has attracted more and more attention from researchers in the field of wearable energy storage devices. In addition, certain components are loaded on it to improve electrochemical performance and further promote its advantages. Here, we first carbonized commercial melamine foam in N2 atmosphere to form in situ doping and then used a simple hydro-thermal reaction to uniformly load MnO2 nanosheet arrays on its three-dimensional framework. For the resulting electrode material, the specific capacitance was as high as 230.3 F/g under the current density of 1 A/g. With the voltage window of 0–2.2 V, the energy density of the assembled quasi-solid supercapacitor reached 29.73 Wh/kg with the power density of 1636.9 W/kg, showing great electrochemistry performance and application prospects.

The leakage of chemical compounds in landfill leachate led to serious environment pollution, especially, the compounds termed endocrine disruptors such as bisphenol A (BPA). It is very important to study the adsorption behavior of endocrine disruptors in modified soil for predicting and evaluating the potential harm of endocrine disruptors to the soil. Bentonite-amended Chinese loess mixtures, with various proportions of bentonite, were used for the removal of BPA from an aqueous solution. A batch test was used to investigate the adsorption properties of bisphenol A on bentonite and Chinese loess mixtures. The influences of bentonite proportion, temperature, reaction time, pH, and soil-water ratios on the adsorption process were considered. The Fourier transform infrared spectra (FTIR) was used to clarify the change of functional groups before and after the adsorption of BPA on soil. The adsorption mechanism of BPA on soil was discussed preliminary. The results show that the addition of bentonite to the loess can improve the adsorption rate of BPA. The adsorption of BPA was mainly a spontaneous, exothermic, entropy decreasing physical adsorption process. The interaction between bentonite content and reaction concentration had a beneficial effect on BPA adsorption. The linear relationship between bentonite content and adsorption capacity was obtained. The results indicate that bentonite amended loess can provide a good liner for BPA.

The inferior cycle lifespan and unsatisfactory energy density of traditional anode materials for sodium-ion batteries need to be improved toward actual application. Here, MOF-derived ultrafine ZnSe...

Alloying-type anode materials are regarded as promising alternatives beyond intercalation-type carbonaceous materials for sodium storage owing to the high specific capacities. The rapid capacity decay arising from the huge volume change during Na+-ion insertion/extraction, however, impedes the practical application. Herein, we report an ultrafine antimony embedded in a porous carbon nanocomposite (Sb@PC) synthesized via facile in situ substitution of the Cu nanoparticles in a metal-organic framework (MOF)-derived octahedron carbon framework for sodium storage. The Sb@PC composite displays an appropriate redox potential (0.5-0.8 V vs Na/Na+) and excellent specific capacities of 634.6, 474.5, and 451.9 mAh g-1 at 0.1, 0.2, and 0.5 A g-1 after 200, 500, and 250 cycles, respectively. Such superior sodium storage performance is primarily ascribed to the MOF-derived three-dimensional porous carbon framework and ultrafine Sb nanoparticles, which not only provides a penetrating network for rapid transfer of charge carriers but also alleviates the agglomeration and volume expansion of Sb during cycling. Ex situ X-ray diffraction and in situ Raman analysis clearly reveal a five-stage reaction mechanism during sodiation and desodiation and demonstrate the excellent reversibility of Sb@PC for sodium storage. Furthermore, post-mortem analysis reveals that the robust structural integrity of Sb@PC can withstand continuous Na+-ion insertion/extraction. This work may provide insight into the effective design of high-capacity alloying-type anode materials for advanced secondary batteries.