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251. Large Scale Ex Vivo GMP Expanded, Activated Human T Cells Consistently Induce Lethal GvHD in a Mouse Xenotransplant Model - A New Way To Study Treatments for Acute GvHD

252. Tracking Differential Repopulation Kinetics of Human Hematopoietic Progenitor Cells Using MRI Detection of Nanoparticles

253. Human CD34+Cells Mobilized by AMD3100 Demonstrate Enhanced NOD/SCID Repopulating Function Compared to CD34+ Cells Mobilized by Granulocyte Colony Stimulating Factor

254. Exploring the Molecular Mechanisms for Enhancing MSC Homing and Lodgement within Sites of Liver Damage/Fibrosis

255. Bone Marrow-Derived Aldehyde Dehdrogenase Expressing Cells Possess Endothelial Progenitor Function in Addition to Hematopoietic Repopulating Ability and Aid in Blood Flow Recovery after Acute Ischemic Injury

256. In Vivo Imaging and Tracking of Defined, Repopulating Human Stem Cell Subsets Using Fluorescence Conjugated Nanoparticles in a Clinically Applicable Ex Vivo Protocol

257. Uptake of Protamine Sulphate Complexed Fluorescent Nano-Particles Is Defined by Cell Cycle Status in Primary Human CD34+ Cells: Use of a Multi-Color p27 kip1 Based Flow Cytometric Assay

258. Working Toward Better Tissue Repair Therapies: Exposure of MSC to Hypoxic Conditions In Vitro Increases Levels of the Hepatocyte Growth Factor Receptor c-met, Improves Motility, and Induces Phosphorylation of the Pro-Survival Protein AKT

259. Naive and Ex Vivo Activated Human T Cells Generate Consistent Engraftment and Lethal Graft-Versus-Host Disease (GvHD) in NOD SCID β 2M Null Mice: A New Xenogeneic Model for GvHD

260. Comparison of Human Stem Cell Homing after Intravenous or Intra-Femoral Transplantation Using Multimodal In Vivo Imaging of Repopulating Human CD34+ Cells Labeled with Far-Red Fluorescent-Conjugated Nanoparticles

261. 1121. Osteogenic Growth Peptide Preferentially Enhances Trabecular Bone Mass

262. 1032. Hepatocyte Growth Factor Maintains Hematopoietic Progenitors during Retroviral Transduction

263. 353. Retrovirally-Marked Human Bone Marrow Derived Mesenchymal Stem Cells Attenuate Radiation Induced Pneumonitis in a Xenotransplant Model

264. 288. A System for GMP Expansion and Transduction of Human T Cells with High Functionality Proven by Consistent Induction of GvHD in a Mouse Xenotransplant Model

265. 1035. Use of Multi Color p27kip1 Based Flow Cytometric Assay To Evaluate and Characterize G0 to G1 Cell Cycle Related Changes in Human Hematopoietic Cells after Subjection to a Clinically Applicable Ex Vivo Transduction Protocol

266. 1031. Purification of Cells with High Aldehyde Dehydrogenase Activity Reveals a CD133 Negative Population with Enhanced Repopulating Ability after Ex Vivo Culture

267. 457. The Benefits of CH-296 during Ex Vivo Gene Transfer Go beyond the Ability to Co-Localize the Retroviral Particle and Target Cell

268. 783. Transient Transduction of Repopulating Human CD34 Cells Using Nanoparticles in a Clinically Applicable Ex Vivo Protocol

269. 460. Transplantation of Human Aldehyde Dehydrogenase Expressing Cells Leads to Widespread Tissue Distribution of Donor Cells in the Pancreas and Liver of NOD/SCID/MPSVII Mice

270. 243. Transplantation of Neonatal NOD/SCID/MPSVII Mice with Human Mesenchymal Stem Cells

271. 810. Ex-Vivo Activation and Genetic Manipulation of Human T Cells Results in Consistent In-Vivo Expansion and Lethal GvHD in a Novel Murine Xenotransplant Model

272. 1037. Adherent Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Do Not Augment Viral Gene Transfer into Hematopoietic Stem/Progenitor Cells

273. CD133-Expressing Cells with High Aldehyde Dehydrogenase Activity Represent a Primitive Human Hematopoietic Stem Cell Population with Enhanced Repopulating Potential

274. GMP Scale up for a Clinical Gene Therapy Trial - High Efficiency Human T Cell Expansion and Transduction in a Closed Culture System Utilizing Serumfree Medium and Low IL-2 Concentrations

275. A Pilot Study Evaluating the Safety and Efficacy of AMD3100 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients with Advanced Hematological Malignancies

276. In Vivo Suicide Gene Therapy of Human T Lymphocytes To Prevent Graft Versus Host Disease in a Murine Xenograft Model

277. Isolation of Human CD34- Cells with High Aldehyde Dehydrogenase Activity Reveals a Novel Population with Hematopoietic Repopulating Potential

278. Transplantation of Human Aldehyde Dehydrogenase Expressing Cells Leads to Widespread Tissue Distribution of Donor Cells in the Novel NOD/SCID/MPSVII Xenotransplantation Model

279. A Murine Xenograft Model for Human T Cell Mediated Graft Versus Host Disease

280. Multilineage Analysis of Paired AMD-3100 and G-CSF Mobilized-Peripheral Blood Stem Cell Products from Healthy Donors Undergoing Clinical Mobilization: A Pilot Study

281. Use of Multi Color P27kip1 Based Flow Cytometric Assay To Evaluate and Characterize G0 to G1 Cell Cycle Related Changes in Human Hematopoietic Cells after Subjection to a Clinically Applicable Ex Vivo Transduction Protocol

282. 606. The NOD-SCID β2M Null Mouse Xenograft Model for Studying Activation, Expansion and GvHD Potential of Gene Transduced Human T Cells In Vivo

283. Migration of mesenchymal progenitors to heart allograft: evidence for active participation of mesenchymal stem cells in tissue repair and inadvertent attribution to graft fibrosis

284. Extrathymic human t lymphocyte development and regulation in immune deficient mice

285. Integrin engagement on fibronectin modulates the protein levels of c-myb, CD34, P21, and P130 in primary human hematopoietic progenitors

286. EFFECTIVE IMMUNE RECONSTITUTION IN MICE AFTER CO-TRANSPLANTATION OF BONE MARROW AND MARROW STROMA TRANSDUCED WITH THE IL-7 GENE: GENE THERAPY FOR POST-BMT IMMUNE DEFICIENCY. • 40

287. Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

288. A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways

289. Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages

290. Clinical infection control in gene therapy: A multidisciplinary conference

291. Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model

293. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies

294. Clinical trial perspective for adult and juvenile Huntington′s disease using genetically-engineered mesenchymal stem cells

295. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro.

296. Lysophosphatidic acid enhances stromal cell-directed angiogenesis.

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