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262. Propagation and dispersion of electrostatic waves in the ionospheric E region

Author

K. Iranpour, H. L. Pécseli, J. Trulsen, A. Bahnsen, F. Primdahl, and K. Rinnert

Subjects
Science, Physics, QC1-999, Geophysics. Cosmic physics, QC801-809
Abstract

Low-frequency electrostatic fluctuations in the ionospheric E region were detected by instruments on the ROSE rockets. The phase velocity and dispersion of plasma waves in the ionospheric E region are determined by band-pass filtering and cross-correlating data of the electric-field fluctuations detected by the probes on the ROSE F4 rocket. The results were confirmed by a different method of analysis of the same data. The results show that the waves propagate in the Hall-current direction with a velocity somewhat below the ion sound speed obtained for ionospheric conditions during the flight. It is also found that the waves are dispersive, with the longest wavelengths propagating with the lowest velocity.

Published
1997
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267. Comparison of chest CT scan findings between COVID-19 and pulmonary contusion in trauma patients based on RSNA criteria: Established novel criteria for trauma victims.

Author

Abdolrahimzadeh Fard, Hossein, Mahmudi-Azer, Salahaddin, Abdulzahraa Yaqoob, Qusay, Sabetian, Golnar, Iranpour, Pooya, Shayan, Zahra, Bolandparvaz, Shahram, Abbasi, Hamid Reza, Aminnia, Shiva, Salimi, Maryam, Mahmoudi, Mohammad Mehdi, Paydar, Shahram, Borazjani, Roham, Taheri Akerdi, Ali, Zare, Masome, Shayan, Leila, and Sasani, Mohammadreza

Abstract

Propose: In this study, we re-assessed the criteria defined by the radiological society of North America (RSNA) to determine novel radiological findings helping the physicians differentiating COVID-19 from pulmonary contusion.Methods: All trauma patients with blunt chest wall trauma and subsequent pulmonary contusion, COVID-19-related signs and symptoms before the trauma were enrolled in this retrospective study from February to May 2020. Included patients (Group P) were then classified into two groups based on polymerase chain reaction tests (Group Pa for positive patients and Pb for negative ones). Moreover, 44 patients from the pre-pandemic period (Group PP) were enrolled. They were matched to Group P regarding age, sex, and trauma-related scores. Two radiologists blindly reviewed the CT images of all enrolled patients according to criteria defined by the RSNA criteria. The radiological findings were compared between Group P and Group PP; statistically significant ones were re-evaluated between Group Pa and Group Pb thereafter. Finally, the sensitivity and specificity of each significant findings were calculated. The Chi-square test was used to compare the radiological findings between Group P and Group PP.Results: In the Group PP, 73.7% of all ground-glass opacities (GGOs) and 80% of all multiple bilateral GGOs were detected (p < 0.001 and p = 0.25, respectively). Single bilateral GGOs were only seen among the Group PP. The Chi-square tests showed that the prevalence of diffused GGOs, multiple unilateral GGOs, multiple consolidations, and multiple bilateral consolidations were significantly higher in the Group P (p = 0.001, 0.01, 0.003, and 0.003, respectively). However, GGOs with irregular borders and single consolidations were more significant among the Group PP (p = 0.01 and 0.003, respectively). Of note, reticular distortions and subpleural spares were exclusively detected in the Group PP.Conclusion: We concluded that the criteria set by RSNA for the diagnosis of COVID-19 are not appropriate in trauma patients. The clinical signs and symptoms are not always useful either. The presence of multiple unilateral GGOs, diffused GGOs, and multiple bilateral consolidations favor COVID-19 with 88%, 97.62%, and 77.7% diagnostic accuracy. [ABSTRACT FROM AUTHOR]

Published
2022
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268. Effect of thymoquinone on P53 gene expression and consequence apoptosis in breast cancer cell line

Author

Mehdi Nikbakht Dastjerdi, Ebrahim Momeni Mehdiabady, Farhad Golshan Iranpour, and Hamid Bahramian

Subjects
Apoptosis, genes P53, Michigan C]ancer Foundation-7 cells, thymoquinone, Medicine
Abstract

Background: Nigella sativa has been a nutritional flavoring factor and natural treatment for many ailments for so many years in medical science. Earlier studies have been reported that thymoquinone (TQ), an active compound of its seed, contains anticancer properties. Previous studies have shown that TQ induces apoptosis in breast cancer cells but it is unclear the role of P53 in the apoptotic pathway. Hereby, this study reports the potency of TQ on expression of tumor suppressor gene P53 and apoptosis induction in breast cancer cell line Michigan Cancer Foundation-7 (MCF-7). Methods: MCF-7 cell line was cultured and treated with TQ, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out for evaluating the half-maximal inhibitory concentration (IC50) values after 24 h of treatment. The percentage of apoptotic cells was measured by flow cytometry. Real-time polymerase chain reaction (PCR) was performed to estimate the messenger RNA expression of P53 in MCF-7 cell line at different times. Results: The IC50 value for the TQ in MCF-7 cells was 25 mM that determined using MTT assay. The flow cytometry and real-time PCR results showed that TQ could induce apoptosis in MCF-7 cells, and the P53 gene expression was dramatically up-regulated by ascending time, respectively. Hence, there was significant difference in 48 and 72 h. Conclusions: Our results demonstrated that TQ could induce apoptosis in MCF-7 cells through up-regulation of P53 expression in breast cancer cell line (MCF-7) by time-dependent manner.

Published
2016
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269. Association between sleep quality and postpartum depression

Author

Sohrab Iranpour, Gholam Reza Kheirabadi, Ahmad Esmaillzadeh, Motahar Heidari-Beni, and Mohammad Reza Maracy

Subjects
Postpartum depression, pregnancy, sleep quality, Medicine
Abstract

Background: The objective of this study was an investigation of the association between depression and sleep quality. Materials and Methods: This cross-sectional study was performed on 360 delivered women that referred to thirty health-care centers in Ardabil, Iran. The Standard Pittsburgh Sleep Quality Index questionnaire was used to the investigation of sleep quality. We used the Edinburgh Postnatal Depression Questionnaire to assess postpartum depression. Logistic regression was used to examine the association of sleep quality with postpartum depression. Results: Chance of depression in women with poor sleep quality was 3.34 times higher than those with good sleep quality (odds ratio = 3.34; 95% confidence interval: 2.04–5.48; P< 0.001). After controlling for some risk factors, an association observed between sleep quality and depression in postpartum women. Conclusion: we found an association between sleep quality in women who had given birth in the last 3 months and symptoms of postpartum depression.

Published
2016
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270. TTF2 Gene Mutation in Neonates with Congenital Hypothyroidism Caused by Thyroid Dysgenesis

Author

Frouzande Mahjoubi, Mahin Hashemipour, Ramin Iranpour, Massoud Amini, and Silva Hovsepian

Subjects
Medicine, Medicine (General), R5-920
Abstract

Background: Thyroid transcription factor 2 (TTF2) or forkhead box E1 (FOXE1) is a polyalanine domain protein with an important role in the morphogenesis and development of thyroid gland. Mutations of TTF2 gene have been identified in neonates with congenital hypothyroidism caused by thyroid dysgenesis. In this study, the mutations of TTF2 gene were studied among these patients. Methods: In this study, the entire TTF2 gene of 50 neonates with congenital hypothyroidism due to thyroid dysgenesis who referred to Isfahan Endocrine and Metabolism Research Center (Isfahan, Iran) was studied by direct DNA sequencing. The mutations were assessed after amplification of TTF2 gene by polymerase chain reaction (PCR) method. Mutations of each exon of TTF2 gene were evaluated by the adjacent primers of the whole encoding region. Findings: We did not find any mutation in TTF2 gene. There was a serotonin polymorphism among 74% of studied patients. The length of TTF2 polyalanine tract was 14 amino acids in most patients. Conclusion: The findings of this study indicated the possible correlation between TTF2 polyalanine tract length polymorphism and genetic susceptibility to thyroid dysgenesis among patients with congenital hypothyroidism. Keywords: Congenital hypothyroidism, Thyroid transcription factor 2, Thyroid dysgenesis

Published
2012

271. RESIDUAL EFFECT OF LAMBDACYHALOTHRIN (ICON 10% WP) ON DIFFERENT SURFACES IN SOUTH OF IRAN

Author

H. Ladonni, M. Motabar, and M. Iranpour

Subjects
Lambdacyhalothrin, Public aspects of medicine, RA1-1270
Abstract

An investigation was made to study the residual activity and air-borne effect of lambdacyhalothrin (Icon 10 WP) at 30, 40 and 50 a.i. mg/rn2 against An.stephensi in hut scale trials on different surfaces in Mamasani, and Rudan, south of Iran. Bio-assay contact mortality test with Icon at 30 a.i. mgl/m2 on plaster, cement and wood surfaces decreased from 100% to 51.4%, 53% and 63.8% after 84, 80 and 107 days of hut spraying, respectively. At 40 a.i mg/m2 Icon showed longer residual activity than the 30 mg/rn2, i.e. the mortality rate deceased from 100% to 50.7% for plaster, to 52.5% for cement and to 53.5% for wood surfaces, after 105, 105 and 124 days of hut spraying, respectively. Icon at 50 a.i. mg/m2 showed longer residual activity than the former dosages, i.e. the mortality dropped from 100% to 62.1% for plaster, to 50.7% for cement and to 90.4% for wooden surfaces, after 124 days of hut spraying, respectively. The result of air home tests showed that Icon has negligible or slight killing effect on An.stephensi, i.e. at 30. 40 and 50 a.i. mg/m2, the mortality rates dropped from 100% to about 60% after 10, 15 and 25 days of hut spraying, respectively. Based on the results of this study lambdacyhalothrin at 50/m2 had a residual activity for more than 4 months on different surface. It could be concluded that, lambdacyhalothrin at 50 mg/m2 might be a candidate dosage for continuation of study in village scale vial in south of Iran.

Published
1994

272. A Comparison of the Effectiveness of Chloroform in Dissolving Dissolving Resilon and Gutta-Percha

Author

MR. Azar, L. Khojastehpour, and N. Iranpour

Subjects
Solubility, Chloroform, Resilon sealer, Gutta-Percha, Solvents, Dentistry, RK1-715
Abstract

Objective: Application of chemical solvents especially in problematic canals is usually a part of the retreatment process.This study was performed to compare the solubility of Gutta- Percha and Resilon in chloroform and to find the effect of sample thickness as well as the time of shaking on their solubility. Materials and Methods: Specific weight of Resilon and gutta-percha was placed in a sample tube and after adding 1.0 ml of chloroform at 37ºC, the tubes were capped and shaked for 1, 3 and 5 minutes. The amount of non dissolved material was determined by reweighting of each sample and the percent of solubility was assessed according to the exact weight loss of the samples. The procedure was repeated three times for a given thickness and time of shaking. The difference in the solubility of Gutta-Percha and Resilon as well as the effect of sample thickness and time of shaking on solubility were assessed by repeated measurement ANOVA (p

Published
2011

274. SERUM LEPTIN LEVELS OF MATERNAL-CORD PAIRS IN INTRAUTERINE GROWTH-RETARDED AND NORMAL TERM NEONATES

Author

Ramin Iranpour, Ali Havai, Roya Kelishadi, Sedigheh Asgary, and Mahin Hashemipour

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract INTRODUCTION: It is well documented that low birth weight may increase the risk of chronic diseases, notably atherosclerotic cardiovascular disease, later in life. However, the mechanisms of maternal and fetal weight regulation during pregnancy are not clearly defined, and leptin might play a role in this process. This study was performed to compare the serum leptin levels in normal and intrauterine growth-retarded (IUGR) term neonates. In addition, we aimed to determine the relationships of maternal and neonatal leptin concentrations with birth weight. methods: From April 2005 to December 2005, serum leptin concentration was measured in umbilical cord and maternal venous blood samples of 32 mother-infant pairs with IUGR full-term neonates and 34 mother-infant pairs with normal full-term neonates. Independent sample t-test was used for the comparisons. The correlation analysis was performed by Pearson correlation coefficient. results: The mean leptin concentration in newborns with IUGR and in their mothers (2.82±1.95 and 3.16±2 µg/L, respectively) was lower than in infants with normal growth and their mothers (3.04±1.74 and 3.18±1.97 µg/L, respectively) but these differences were not significant. Cord blood leptin concentrations did not correlate with birth weights (r=0.02), BMI of neonates (r=0.033), or leptin concentrations of their mothers (r=0.17). When data of all newborn infants were collectively analyzed, cord blood leptin concentration in the IUGR group correlated with BMI of neonates (r=0.36, P=0.03) but not with birth weight (r=0.22, P=0.20). There was no significant difference in terms of gender. CONCLUSIONS: Cord blood leptin levels appear to correlate with BMI, as an indicator of fat mass, but not the birth weight of IUGR neonates. In addition, maternal leptin concentration cannot be considered as an accurate indicator of fetal growth. Keywords: Leptin, intrauterine growth retardation, cord blood, neonate.

Published
2010

275. Homocystinuria, typical brain MRI findings

Author

P Iranpour, N Karamifar, and K As’adi

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

An 8-year-old male presented with recent history of headache, several episodes of convulsion and visual field deficits. Brain MRI revealed multiple T2 hypersignal intensity foci within the left cerebral peduncle, basal ganglia, thalami and left parietal cortex, believed to represent ischemia. There was also iso–slightly hyperintense signal at the site of superior sagittal sinus, replacing the normal flow void pattern, suggestive for dural sinus thrombosis. After gadolinium injection thrombosis of superior sagittal sinus was confirmed (Fig A). Evaluation of orbits disclosed posterior dislocation of the right lens (Fig B). These findings were compatible with the diagnosis of homocystinuria which was later confirmed by laboratory data.

Published
2010
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276. RESIDUAL AND AIR - BORNE EFFECTS OF PIRIMIPHOS - METHYL ON DIFFERENT SURFACES IN SOUTH OF IRAN

Author

H. Ladonni, M. Motabar, and M. Iranpour "

Subjects
Pirimiphos- methyl, Air-borne effect, Public aspects of medicine, RA1-1270
Abstract

An investigation was made to study the residual activity and air- borne effect of pirimiphos- methyl, at 2g a.i./m2 in hut scale trials on different surfaces in kazeroun, and Bandar-Abbas, south of Iran. In Kazeroun area, bio-assay contact mortality test with pirimiphos methyl on mud, wood, cement and plaster surfaces, 54 days after hut spraying, decreased from 100% to 46.7%, 61.25%, 36.6% and 40%, respectively. In Baridar-Abbas area, after 72 days of hut spraying, the mortalities on cement and plasters surfaces decreased from 100% to 63.4% and 45.4%, respectively. The fumigation effect of pirirnlphosmcthyl on mud and plaster walls with wooden ceiling were studied in Kazeroun. ‘The activity of pirimiphos- methyl on mud and plaster surfaces dropped from 100% to 52% and 46.53% after 54 days of hut spraying respectively. The results suggested that pirimiphos-methyl has effective contact and vapour effect at least for about 50 days on different surfaces in south of Iran.

Published
1992

278. Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review

Author

Hajsadeghi, Shokoufeh, Iranpour, Aida, Amouei, Erfan, Tehrani, Nasim Hoshangian, Ghavidel, Alireza, Ziaie, Hossein, Asadi, Omolbanin, Moradians, Vahan, Tayebi, Ali, Mestres, Carlos-A., and Manqoutaei, Sanaz Abdollahzade

Abstract

Objective Primary and metastatic primitive neuroectodermal tumors of the pericardium are uncommon. Two cases are presented and discussed.Methods The cases of a 17- and 38-year-old male patients with neuroectodermal tumors of the pericardium are presented. In addition, a systematic review was performed according to the Preferred Reporting Items and checklist for Systematic reviews and Meta-Analyses (PRISMA). All selected articles’ quality assessment was done using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports.Results The systematic review yielded 29 patients with primary or metastatic PNET. Two patients underwent cardiac transplantation. It seems that unlike considering total resection in other organs, pericardiectomy in PNET patients with pericardial origin may lead to further invasion of the lesions, and it is not recommended. The average disease-free follow-up was 10 months. The combination of neoadjuvant and adjuvant chemotherapy along with surgery and radiotherapy offered the best disease-free outcomes.Conclusion Neuroectodermal heart tumors are rare, aggressive tumors requiring chemotherapy and radiotherapy in association with tumor resection surgery to have the best disease-free duration.

Published
2022
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279. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Author

Tran, Khanh Bao, Lang, Justin J, Compton, Kelly, Xu, Rixing, Acheson, Alistair R, Henrikson, Hannah Jacqueline, Kocarnik, Jonathan M, Penberthy, Louise, Aali, Amirali, Abbas, Qamar, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed Abdelwahab, Abdoli, Gholamreza, Abdulkadir, Hanan Abdulkadir, Abedi, Aidin, Abegaz, Kedir Hussein, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Absalan, Abdorrahim, Abtew, Yonas Derso, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Acuna, Juan Manuel, Addison, Daniel, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adesina, Miracle Ayomikun, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afrin, Sumia, Afzal, Muhammad Sohail, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed Rashid, Tarik, Aiman, Wajeeha, Ajami, Marjan, Akalu, Gizachew Taddesse, Akbarzadeh-Khiavi, Mostafa, Aklilu, Addis, Akonde, Maxwell, Akunna, Chisom Joyqueenet, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alessy, Saleh Ali, Algammal, Abdelazeem M, Al-Hanawi, Mohammed Khaled, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alqalyoobi, Shehabaldin, Al-Raddadi, Rajaa M, Al-Rifai, Rami H Hani, Al-Sabah, Salman Khalifah, Al-Tammemi, Ala'a B, Altawalah, Haya, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Aminian Dehkordi, Javad Javad, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderson, Jason A, Animut, Yaregal Animut, Anoushiravani, Amir, Anoushirvani, Ali Arash, Ansari-Moghaddam, Alireza, Ansha, Mustafa Geleto, Antony, Benny, Antwi, Maxwell Hubert, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Aremu, Olatunde, Argaw, Ayele Mamo, Ariffin, Hany, Aripov, Timur, Arshad, Muhammad, Artaman, Al, Arulappan, Judie, Aruleba, Raphael Taiwo, Aryannejad, Armin, Asaad, Malke, Asemahagn, Mulusew A, Asemi, Zatollah, Asghari-Jafarabadi, Mohammad, Ashraf, Tahira, Assadi, Reza, Athar, Mohammad, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Attia, Sameh, Aujayeb, Avinash, Ausloos, Marcel, Avila-Burgos, Leticia, Awedew, Atalel Fentahun, Awoke, Mamaru Ayenew, Awoke, Tewachew, Ayala Quintanilla, Beatriz Paulina, Ayana, Tegegn Mulatu, Ayen, Solomon Shitu, Azadi, Davood, Azadnajafabad, Sina, Azami-Aghdash, Saber, Azanaw, Melkalem Mamuye, Azangou-Khyavy, Mohammadreza, Azari Jafari, Amirhossein, Azizi, Hosein, Azzam, Ahmed Y Y, Babajani, Amirhesam, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Bagheri, Nader, Bagherieh, Sara, Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L, Bakhtiari, Ahad, Bakshi, Ravleen Kaur, Banach, Maciej, Banerjee, Indrajit, Bardhan, Mainak, Barone-Adesi, Francesco, Barra, Fabio, Barrow, Amadou, Bashir, Nasir Z, Bashiri, Azadeh, Basu, Saurav, Batiha, Abdul-Monim Mohammad, Begum, Aeysha, Bekele, Alehegn Bekele, Belay, Alemayehu Sayih, Belete, Melaku Ashagrie, Belgaumi, Uzma Iqbal, Bell, Arielle Wilder, Belo, Luis, Benzian, Habib, Berhie, Alemshet Yirga, Bermudez, Amiel Nazer C, Bernabe, Eduardo, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhandari, Bharti Bhandari, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bhuyan, Soumitra S, Bibi, Sadia, Bilchut, Awraris Hailu, Bintoro, Bagas Suryo, Biondi, Antonio, Birega, Mesfin Geremaw Birega, Birhan, Habitu Eshetu, Bjørge, Tone, Blyuss, Oleg, Bodicha, Belay Boda Abule, Bolla, Srinivasa Rao, Boloor, Archith, Bosetti, Cristina, Braithwaite, Dejana, Brauer, Michael, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Buchanan, Christina Maree, Bulamu, Norma B, Bustamante-Teixeira, Maria Teresa, Butt, Muhammad Hammad, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cámera, Luis Alberto, Cao, Chao, Cao, Yin, Carreras, Giulia, Carvalho, Márcia, Cembranel, Francieli, Cerin, Ester, Chakraborty, Promit Ananyo, Charalampous, Periklis, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chirinos-Caceres, Jesus Lorenzo, Cho, Daniel Youngwhan, Cho, William C S, Christopher, Devasahayam J, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Cohen, Aaron J, Conde, Joao, Cortés, Sandra, Costa, Vera Marisa, Cruz-Martins, Natália, Culbreth, Garland T, Dadras, Omid, Dagnaw, Fentaw Teshome, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Danielewicz, Anna, Dao, An Thi Minh, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Das, Saswati, Davitoiu, Dragos Virgil, Davtalab Esmaeili, Elham, De la Hoz, Fernando Pio, Debela, Sisay Abebe, Dehghan, Azizallah, Demisse, Biniyam, Demisse, Fitsum Wolde, Denova-Gutiérrez, Edgar, Derakhshani, Afshin, Derbew Molla, Meseret, Dereje, Diriba, Deribe, Kalkidan Solomon, Desai, Rupak, Desalegn, Markos Desalegn, Dessalegn, Fikadu Nugusu, Dessalegni, Samuel Abebe A, Dessie, Gashaw, Desta, Abebaw Alemayehu, Dewan, Syed Masudur Rahman, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dixit, Shilpi Gupta, Doaei, Saeid, Doan, Linh Phuong, Doku, Paul Narh, Dongarwar, Deepa, dos Santos, Wendel Mombaque, Driscoll, Tim Robert, Dsouza, Haneil Larson, Durojaiye, Oyewole Christopher, Edalati, Sareh, Eghbalian, Fatemeh, Ehsani-Chimeh, Elham, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Ekwueme, Donatus U, El Tantawi, Maha, Elbahnasawy, Mostafa Ahmed, Elbarazi, Iffat, Elghazaly, Hesham, Elhadi, Muhammed, El-Huneidi, Waseem, Emamian, Mohammad Hassan, Engelbert Bain, Luchuo, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Eshetu, Tegegne, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Etaee, Farshid, Etemadimanesh, Azin, Eyayu, Tahir, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Fakhradiyev, Ildar Ravisovich, Faraon, Emerito Jose A, Fares, Jawad, Farmany, Abbas, Farooque, Umar, Farrokhpour, Hossein, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fatima, Wafa, Fattahi, Hamed, Fekadu, Ginenus, Feleke, Berhanu Elfu, Ferrari, Allegra Allegra, Ferrero, Simone, Ferro Desideri, Lorenzo, Filip, Irina, Fischer, Florian, Foroumadi, Roham, Foroutan, Masoud, Fukumoto, Takeshi, Gaal, Peter Andras, Gad, Mohamed M, Gadanya, Muktar A, Gaipov, Abduzhappar, Galehdar, Nasrin, Gallus, Silvano, Garg, Tushar, Gaspar Fonseca, Mariana, Gebremariam, Yosef Haile, Gebremeskel, Teferi Gebru, Gebremichael, Mathewos Alemu, Geda, Yohannes Fikadu, Gela, Yibeltal Yismaw, Gemeda, Belete Negese Belete, Getachew, Melaku, Getachew, Motuma Erena, Ghaffari, Kazem, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghasemi Nour, Mohammad, Ghassemi, Fariba, Ghimire, Ajnish, Ghith, Nermin, Gholamalizadeh, Maryam, Gholizadeh Navashenaq, Jamshid, Ghozy, Sherief, Gilani, Syed Amir, Gill, Paramjit Singh, Ginindza, Themba G, Gizaw, Abraham Tamirat T, Glasbey, James C, Godos, Justyna, Goel, Amit, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Golitaleb, Mohamad, Gorini, Giuseppe, Goulart, Bárbara Niegia Garcia, Grosso, Giuseppe, Guadie, Habtamu Alganeh, Gubari, Mohammed Ibrahim Mohialdeen, Gudayu, Temesgen Worku, Guerra, Maximiliano Ribeiro, Gunawardane, Damitha Asanga, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Gurara, Mekdes Kondale, Guta, Alemu, Habibzadeh, Parham, Haddadi Avval, Atlas, Hafezi-Nejad, Nima, Hajj Ali, Adel, Haj-Mirzaian, Arvin, Halboub, Esam S, Halimi, Aram, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Hanif, Asif, Hariri, Sanam, Harlianto, Netanja I, Haro, Josep Maria, Hartono, Risky Kusuma, Hasaballah, Ahmed I, Hasan, S M Mahmudul, Hasani, Hamidreza, Hashemi, Seyedeh Melika, Hassan, Abbas M, Hassanipour, Soheil, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Heidarymeybodi, Zahra, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hezam, Kamal, Hiraike, Yuta, Hlongwa, Mbuzeleni Mbuzeleni, Holla, Ramesh, Holm, Marianne, Horita, Nobuyuki, Hoseini, Mohammad, Hossain, Md Mahbub, Hossain, Mohammad Bellal Hossain, Hosseini, Mohammad-Salar, Hosseinzadeh, Ali, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Hugo, Fernando N, Humayun, Ayesha, Hussain, Salman, Hussein, Nawfal R, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Iftikhar, Pulwasha Maria, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Innos, Kaire, Iranpour, Pooya, Irham, Lalu Muhammad, Islam, Md Shariful, Islam, Rakibul M, Islami, Farhad, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, J, Linda Merin, Jaiswal, Abhishek, 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Maryam, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Abbas, Khan, Abdul Aziz Khan, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khan, Moien AB, Khanali, Javad, Khatab, Khaled, Khatatbeh, Moawiah Mohammad, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khayat Kashani, Hamid Reza, Khazeei Tabari, Mohammad Amin, Khezeli, Mehdi, Khodadost, Mahmoud, Kim, Min Seo, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Klugar, Miloslav, Klugarová, Jitka, Kolahi, Ali-Asghar, Kolkhir, Pavel, Kompani, Farzad, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Yuvaraj, Kucuk Bicer, Burcu, Kugbey, Nuworza, Kulimbet, Mukhtar, Kumar, Akshay, Kumar, G Anil, Kumar, Narinder, Kurmi, Om P, Kuttikkattu, Ambily, La Vecchia, Carlo, Lahiri, Arista, Lal, Dharmesh Kumar, Lám, Judit, Lan, Qing, Landires, Iván, Larijani, Bagher, Lasrado, Savita, Lau, Jerrald, Lauriola, Paolo, Ledda, Caterina, Lee, Sang-woong, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lee, Yeong Yeh, 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Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oghenetega, Onome Bright, Ogunsakin, Ropo Ebenezer, Oguntade, Ayodipupo Sikiru, Oh, In-Hwan, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Olagunju, Andrew T, Olagunju, Tinuke O, Olakunde, Babayemi Oluwaseun, Olufadewa, Isaac Iyinoluwa, Omer, Emad, Omonisi, Abidemi E Emmanuel, Ong, Sokking, Onwujekwe, Obinna E, Orru, Hans, Otstavnov, Stanislav S, Oulhaj, Abderrahim, Oumer, Bilcha, Owopetu, Oluwatomi Funbi, Oyinloye, Babatunji Emmanuel, P A, Mahesh, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pakbin, Babak, Pakshir, Keyvan, Pakzad, Reza, Palicz, Tamás, Pana, Adrian, Pandey, Anamika, Pandey, Ashok, Pant, Suman, Pardhan, Shahina, Park, Eun-Cheol, Park, Eun-Kee, Park, Seoyeon, Patel, Jay, Pati, Siddhartha, Paudel, Rajan, Paudel, Uttam, Paun, Mihaela, Pazoki Toroudi, Hamidreza, Peng, Minjin, Pereira, Jeevan, Pereira, Renato B, Perna, Simone, Perumalsamy, Navaraj, Pestell, Richard G, Pezzani, Raffaele, Piccinelli, Cristiano, Pillay, Julian David, Piracha, Zahra Zahid, Pischon, Tobias, Postma, Maarten J, Pourabhari Langroudi, Ashkan, Pourshams, Akram, Pourtaheri, Naeimeh, Prashant, Akila, Qadir, Mirza Muhammad Fahd, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Raeisi, Mojtaba, Rafiee, Ata, Rafiei, Alireza, Raheem, Nasiru, Rahim, Fakher, Rahman, Md Obaidur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajai, Nazanin, Rajesh, Aashish, Ram, Pradhum, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Kamal, Ranasinghe, Priyanga, Rao, Chythra R, Rao, Sowmya J, Rashedi, Sina, Rashidi, Amirfarzan, Rashidi, Mahsa, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Rehman, Ashfaq Ur, Rehman, Inayat ur, Reitsma, Marissa B, Renzaho, Andre M N, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaei, Saeid, Rezaeian, Mohsen, Rezapour, Aziz, Riad, Abanoub, Rikhtegar, Reza, Rios-Blancas, Maria, Roberts, Thomas J, Rohloff, Peter, Romero-Rodríguez, Esperanza, Roshandel, Gholamreza, Rwegerera, Godfrey M, S, Manjula, Saber-Ayad, Maha Mohamed, Saberzadeh-Ardestani, Bahar, Sabour, Siamak, Saddik, Basema, Sadeghi, Erfan, Saeb, Mohammad Reza, Saeed, Umar, Safaei, Mohsen, Safary, Azam, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahoo, Harihar, Sajid, Mirza Rizwan, Salari, Hedayat, Salehi, Sana, Salem, Marwa Rashad, Salimzadeh, Hamideh, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sankararaman, Senthilkumar, Sanmarchi, Francesco, Santric-Milicevic, Milena M, Saqib, Muhammad Arif Nadeem, Sarveazad, Arash, Sarvi, Fatemeh, Sathian, Brijesh, Satpathy, Maheswar, Sayegh, Nicolas, Schneider, Ione Jayce Ceola, Schwarzinger, Michaël, Šekerija, Mario, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Seylani, Allen, Seyoum, Kenbon, Sha, Feng, Shafaat, Omid, Shah, Pritik A, Shahabi, Saeed, Shahid, Izza, Shahrbaf, Mohammad Amin, Shahsavari, Hamid R, Shaikh, Masood Ali, Shaka, Mohammed Feyisso, Shaker, Elaheh, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharifi, Azam, Sharifi-Rad, Javad, Sharma, Purva, Shashamo, Bereket Beyene, Sheikh, Aziz, Sheikh, Mahdi, Sheikhbahaei, Sara, Sheikhi, Rahim Ali, Sheikhy, Ali, Shepherd, Peter Robin, Shetty, Adithi, Shetty, Jeevan K, Shetty, Ranjitha S, Shibuya, Kenji, Shirkoohi, Reza, Shirzad-Aski, Hesamaddin, Shivakumar, K M, Shivalli, Siddharudha, Shivarov, Velizar, Shobeiri, Parnian, Shokri Varniab, Zahra, Shorofi, Seyed Afshin, Shrestha, Sunil, Sibhat, Migbar Mekonnen, Siddappa Malleshappa, Sudeep K, Sidemo, Negussie Boti, Silva, Diego Augusto Santos, Silva, Luís Manuel Lopes Rodrigues, Silva Julian, Guilherme, Silvestris, Nicola, Simegn, Wudneh, Singh, Achintya Dinesh, Singh, Ambrish, Singh, Garima, Singh, Harpreet, Singh, Jasvinder A, Singh, Jitendra Kumar, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinke, Abiy H, Siraj, Md Shahjahan, Sitas, Freddy, Siwal, Samarjeet Singh, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Socea, Bogdan, Soeberg, Matthew J, Sofi-Mahmudi, Ahmad, Solomon, Yonatan, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soshnikov, Sergey, Sotoudeh, Houman, Sowe, Alieu, Sufiyan, Mu'awiyyah Babale, Suk, Ryan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Saima, Sur, Daniel, Szócska, Miklós, Tabaeian, Seidamir Pasha, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabuchi, Takahiro, Tadbiri, Hooman, Taheri, Ensiyeh, Taheri, Majid, Taheri Soodejani, Moslem, Takahashi, Ken, Talaat, Iman M, Tampa, Mircea, Tan, Ker-Kan, Tat, Nathan Y, Tat, Vivian Y, Tavakoli, Ahmad, Tavakoli, Arash, Tehrani-Banihashemi, Arash, Tekalegn, Yohannes, Tesfay, Fisaha Haile, Thapar, Rekha, Thavamani, Aravind, Thoguluva Chandrasekar, Viveksandeep, Thomas, Nihal, Thomas, Nikhil Kenny, Ticoalu, Jansje Henny Vera, Tiyuri, Amir, Tollosa, Daniel Nigusse, Topor-Madry, Roman, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Mai Thi Ngoc, Tripathy, Jaya Prasad, Ukke, Gebresilasea Gendisha, Ullah, Irfan, Ullah, Saif, Ullah, Sana, Unnikrishnan, Bhaskaran, Vacante, Marco, Vaezi, Maryam, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vardavas, Constantine, Varthya, Shoban Babu, Vaziri, Siavash, Velazquez, Diana Zuleika, Veroux, Massimiliano, Villeneuve, Paul J, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vu, Linh Gia, Wadood, Abdul Wadood, Waheed, Yasir, Walde, Mandaras Tariku, Wamai, Richard G, Wang, Cong, Wang, Fang, Wang, Ning, Wang, Yu, Ward, Paul, Waris, Abdul, Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Woldemariam, Melat, Woldu, Berhanu, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yazdanpanah, Fereshteh, Yeshaw, Yigizie, Yismaw, Yazachew, Yonemoto, Naohiro, Younis, Mustafa Z, Yousefi, Zabihollah, Yousefian, Fatemeh, Yu, Chuanhua, Yu, Yong, Yunusa, Ismaeel, Zahir, Mazyar, Zaki, Nazar, Zaman, Burhan Abdullah, Zangiabadian, Moein, Zare, Fariba, Zare, Iman, Zareshahrabadi, Zahra, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zeineddine, Mohammad A, Zhang, Dongyu, Zhang, Jianrong, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhou, Linghui, Zodpey, Sanjay, Zoladl, Mohammad, Vos, Theo, Hay, Simon I, Force, Lisa M, and Murray, Christopher J L

Abstract

Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.

Published
2022
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282. Differentiation of Chest CT Findings Between Influenza Pneumonia and COVID-19: Interobserver Agreement Between Radiologists.

Author

Zarei, Fariba, Jalli, Reza, Iranpour, Pooya, Sefidbakht, Sepideh, Soltanabadi, Sahar, Rezaee, Maryam, Jahankhah, Reza, and Manafi, Alireza

Abstract

Objectives: To investigate the chest CT and clinical characteristics of COVID-19 pneumonia and H1N1 influenza, and explore the radiologist diagnosis differences between COVID-19 and influenza.Materials and Methods: This cross-sectional study included a total of 43 COVID-19-confirmed patients (24 men and 19 women, 49.90 ± 18.70 years) and 41 influenza-confirmed patients (17 men and 24 women, 61.53 ± 19.50 years). Afterwards, the chest CT findings were recorded and 3 radiologists recorded their diagnoses of COVID-19 or of H1N1 influenza based on the CT findings.Results: The most frequent clinical symptom in patients with COVID-19 and H1N1 pneumonia were dyspnea (96.6%) and cough (62.5%), respectively. The CT findings showed that the COVID-19 group was characterized by GGO (88.1%), while the influenza group had features such as GGO (68.4%) and consolidation (66.7%). Compared to the influenza group, the COVID-19 group was more likely to have GGO (88.1% vs. 68.4%, p = 0.032), subpleural sparing (69.0% vs. 7.7%, p <0.001) and subpleural band (50.0% vs. 20.5%, p = 0.006), but less likely to have pleural effusion (4.8% vs. 33.3%, p = 0.001). The agreement rate between the 3 radiologists was 65.8%.Conclusion: Considering similarities of respiratory infections especially H1N1 and COVID-19, it is essential to introduce some clinical and para clinical modalities to help differentiating them. In our study we extracted some lung CT scan findings from patients suspected to COVID-19 as a newly diagnosed infection comparing with influenza pneumonia patients. [ABSTRACT FROM AUTHOR]

Published
2021
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284. Prevalence and determinants of substance use among a sample of Iranian adolescents with ease of access to drugs: an application of Social Development Model

Author

Shahsavari Bami, Roya, Khoshab, Hadi, Fadakar Davarani, Mohammad Mehdi, Jahani, Yunes, Nakhaee, Nouzar, Nadrian, Haidar, and Iranpour, Abedin

Abstract

ABSTRACTThe aim of this study was to investigate the prevalence rate and determinants of SU in adolescents based on the social development model (SDM). In 2018, applying a cross-sectional design, cluster multistage random sampling was employed to recruit 600 adolescents in Bam County, Iran, to participate in the study. A valid and reliable SDM-based instrument was used to collect data. The prevalence rate of using at least one substance was 42% (in girls 33.6% and in boys 50.3%). Adjusted for covariates, having close friends with SU was found as the factor with the highest risk. Higher scores in involvement in prosocial activities and interactions(OR: 0.47; 95% Confidence interval (CI): 0.33–0.66, p < 0.001), attachment and commitment to prosocial others (family and school)(OR: 0.73; 95% CI: 0.58–0.93, p < 0.05), and skills for interaction/involvement(OR: 0.51; 95%CI: 0.39–0.67, p < 0.001) reduced the odds of ever use of SU among adolescents. Also, higher levels of perceived rewards for antisocial interaction/involvement(OR: 2.22; 95% Confidence interval (CI): 1.53–3.22, p < 0.001) and belief in antisocial values(OR: 2.24; 95% CI: 1.67–2.94, p < 0.001) increased the odds of ever use SU among the respondents. In community-based interventions to prevent SU among adolescents, a great focus should be firstly on identifying the probability of SU in close friends. Moreover, the involvement of adolescents in prosocial activities and interactions, attachment and commitment to prosocial others (family and school), and skills for interaction/involvement should be core categories while designing community-based interventional studies.

Published
2022
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285. Health system performance in Iran: a systematic analysis for the Global Burden of Disease Study 2019

Author

Farzadfar, Farshad, Naghavi, Mohsen, Sepanlou, Sadaf G, Saeedi Moghaddam, Sahar, Dangel, William James, Davis Weaver, Nicole, Aminorroaya, Arya, Azadnajafabad, Sina, Koolaji, Sogol, Mohammadi, Esmaeil, Rezaei, Negar, Abbas, Jaffar, Abbasi, Behzad, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdoli, Amir, Abdollahi, Mohammad, Abdollahzade, Sina, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Aghababaei, Soodabeh, Ahadinezhad, Bahman, Ahmadi, Ali, Ahmadi, Sepideh, Ahmadieh, Hamid, Akbari, Mohammad Esmaeil, Alimohamadi, Yousef, Alipour, Vahid, Alizade, Hesam, Alvand, Saba, Amini, Saeed, Amiri, Sohrab, Anoushirvani, Ali Arash, Ansari, Fereshteh, Arabloo, Jalal, Arab-Zozani, Morteza, Aryan, Zahra, Aryannejad, Armin, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Asemi, Zatollah, Asgari, Samaneh, Asgary, Saeed, Asghari, Babak, Asghari Jafarabadi, Mohammad, Ashrafi, Elham, Atafar, Zahra, Athari, Seyyed Shamsadin, Avan, Abolfazl, Azadmehr, Abbas, Azami, Hiva, Azangou-Khyavy, Mohammadreza, Azari, Samad, Azari Jafari, Amirhossein, Azarian, Ghasem, Badirzadeh, Alireza, Bahrami, Elham, Bahrami, Mohammad Amin, Barati, Nastaran, Bayati, Mohsen, Bazmandegan, Gholamreza, Behzadifar, Masoud, Bijani, Ali, Bohlouli, Somayeh, Borzouei, Shiva, Daneshpajouhnejad, Parnaz, Dargahi, Abdollah, Daryani, Ahmad, Davoodi Lahijan, Jalal, Didehdar, Mojtaba, Djalalinia, Shirin, Doaei, Saeid, Dorostkar, Fariba, Doshmangir, Leila, Edraki, Mohammadreza, Emami, Amir, Eshrati, Babak, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Faghani, Shahriar, Fakhar, Mahdi, Farpour, Hamid Reza, Farrokhpour, Hossein, Fasihi Harandi, Majid, Fereidouni, Mohammad, Foroutan, Masoud, Ghafourifard, Mansour, Ghamari, Azin, Ghamari, Seyyed-Hadi, Ghashghaee, Ahmad, Ghassemi, Fariba, Gholami, Ali, Gholamian, Asadollah, Gholizadeh, Abdolmajid, Goharinezhad, Salime, Goleij, Pouya, Hadei, Mostafa, Hafezi-Nejad, Nima, Hariri, Sanam, Hasanpoor, Edris, Hassanian-Moghaddam, Hossein, Hassanipour, Soheil, Hassankhani, Hadi, Heidari, Mohammad, Heidari-Soureshjani, Reza, Hoseini, Mohammad, Hosseini, Mohammad-Salar, Hosseini, Mostafa, Hosseini, Seyed Kianoosh, Hosseinzadeh, Ali, Hosseinzadeh, Mehdi, Hoveidamanesh, Soodabeh, Iranpour, Pooya, Irvani, Seyed Sina Naghibi, Jaafari, Jalil, Jabbarinejad, Roxana, Jafarinia, Morteza, Jafari-Vayghan, Hamed, Jahani, Mohammad Ali, Jahanmehr, Nader, Jalili, Mahsa, Janghorban, Roksana, Javanmardi, Fatemeh, Joukar, Farahnaz, Kabir, Ali, Kalankesh, Leila R, Kalhor, Rohollah, Kamiab, Zahra, Kamyari, Naser, Karami Matin, Behzad, Karimi, Amirali, Karimi, Salah Eddin, Kazemi Karyani, Ali, Keikavoosi-Arani, Leila, Keramati, Maryam, Keshavarz, Pedram, Keykhaei, Mohammad, Khaleghi, Ali, Khammarnia, Mohammad, Khanali, Javad, Khayamzadeh, Maryam, Khosravi, Sajad, Khosravifar, Mina, Khosravizadeh, Omid, Kianipour, Neda, Kolahi, Ali-Asghar, Maali, Amirhosein, Mahdavi, Mokhtar Mahdavi, Maleki, Afshin, Malekpour, Mohammad-Reza, Mansori, Kamyar, Mansouri, Borhan, Mansournia, Mohammad Ali, Maracy, Mohammad Reza, Marjani, Abdoljalal, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Masoumi-Asl, Hossein, Mayeli, Mahsa, Mehrabi Nasab, Entezar, Mehri, Fereshteh, Miri, Mohammad, Mirmoeeni, Seyyedmohammadsadeq, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mohamadkhani, Ashraf, Mohammadi, Heidar, Mohammadi, Seyyede Momeneh, Mohammadi, Shadieh, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohseni, Mohammad, Mokari, Amin, Momtazmanesh, Sara, Moradi, Abdolvahab, Moradi, Masoud, Moradi, Yousef, Moradi-Joo, Mohammad, Moradpour, Farhad, Moradzadeh, Maliheh, Moradzadeh, Rahmatollah, Mosapour, Abbas, Moslehi, Shandiz, Mouodi, Simin, Naderi, Mehdi, Naderifar, Homa, Najafpour, Zhila, Nazari, Javad, Nejadghaderi, Seyed Aria, Nemati-Anaraki, Leila, Nikpoor, Amin Reza, Nojomi, Marzieh, Noori, Maryam, Nouraei, Hasti, Nowroozi, Ali, Oladnabi, Morteza, Pashazadeh Kan, Fatemeh, Pirestani, Majid, Pirsaheb, Meghdad, Pourahmadi, Mohammadreza, Pourchamani, Hadis, Pourjafar, Hadi, Pourshams, Akram, Rabiee, Mohammad, Rabiee, Navid, Rafiei, Alireza, Rafiei, Sima, Rahim, Fakher, Rahmani, Amir Masoud, Rashedi, Sina, Rashedi, Vahid, Rashidi, Amirfarzan, Rashidi, Mahsa, Rashidi, Mohammad-Mahdi, Ravangard, Ramin, Rawassizadeh, Reza, Razeghian-Jahromi, Iman, Razeghinia, Mohammad Sadegh, Redford, Sofia B, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Nima, Rezaei, Saeid, Rezaei Aliabadi, Hossein, Rezaeian, Mohsen, Rezai, Mohammad Sadegh, Rezapour, Aziz, Rezazadeh, Hossein, Rezazadeh-Khadem, Sahba, Rostamian, Morteza, Sadeghi, Ehsan, Sadeghi, Erfan, Sadeghi, Masoumeh, Sadeghian, Reihaneh, Sadeghian, Saeid, Safarpour, Hamid, Safdarian, Mahdi, Safi, Sare, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salahi, Sarvenaz, Salamati, Payman, Samadi Kafil, Hossein, Sarikhani, Yaser, Sarkhosh, Maryam, Sarveazad, Arash, Seyed-Nezhad, Maryam, Shafaat, Omid, Shaghaghi, Zahra, Shahabi, Saeed, Shahin, Sarvenaz, Shaker, Elaheh, Shakiba, Saeed, Shamsi, MohammadBagher, Shamsoddin, Erfan, Sharafi, Kiomars, Sharifian, Sakineh, Shaygan, Maryam, Sheikhtaheri, Abbas, Shiani, Amir, Shirbandi, Kiarash, Shirkoohi, Reza, Shobeiri, Parnian, Shokri, Azad, Siabani, Soraya, Sima, Ali Reza, Sofi-Mahmudi, Ahmad, Soheili, Amin, Soltani, Shahin, Soltani-Zangbar, Mohammad Sadegh, Soofi, Moslem, Tabaeian, Seidamir Pasha, Tabary, Mohammadreza, Tahamtan, Alireza, Taheri, Majid, Taherkhani, Amir, Tajdini, Masih, Tavolinejad, Hamed, Tehrani-Banihashemi, Arash, Tiyuri, Amir, Tohidast, Seyed Abolfazl, Vakilian, Alireza, Valadan Tahbaz, Sahel, Vo, Bay, Yahyazadeh Jabbari, Seyed Hossein, Yazdi-Feyzabadi, Vahid, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Zahir, Mazyar, Zahirian Moghadam, Telma, Zamanian, Maryam, Zandian, Hamed, Zangeneh, Alireza, Zarafshan, Hadi, Zare, Fariba, Zare Dehnavi, Ali, Zarea, Kourosh, Zarei, Ahmad, Zareshahrabadi, Zahra, Ziapour, Arash, Zoghi, Sina, Sarrafzadegan, Nizal, Rahimi-Movaghar, Vafa, Jamshidi, Hamid Reza, Mokdad, Ali H, Hay, Simon I, Murray, Christopher J L, Khosravi, Ardeshir, Moradi-Lakeh, Maziar, Asadi-Lari, Mohsen, Malekzadeh, Reza, and Larijani, Bagher

Abstract

Better evaluation of existing health programmes, appropriate policy making against emerging health threats, and reducing inequalities in Iran rely on a comprehensive national and subnational breakdown of the burden of diseases, injuries, and risk factors.

Published
2022
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286. Photodynamic therapy based on metal-organic framework in cancer treatment: A comprehensive review of integration strategies for synergistic combination therapies

Author

Karbasi, Maryam, Varzandeh, Mohammad, Karbasi, Minoo, Iranpour Mobarakeh, Amirali, Falahati, Mahtab, and Hamblin, Michael R.

Abstract

Recent advancements in cancer therapy have prompted the exploration of innovative and synergistic treatment modalities to minimize side effects and enhance efficacy. Photodynamic therapy (PDT) leverages the ability of photosensitizers (PS) to produce reactive oxygen species (ROS) mediated by molecular oxygen and light. Metal-Organic Framework (MOF) materials are distinguished by their high porosity, abundant surface functional groups, and tunable chemophysical characteristics, which allows for the engineering of nanoparticles for diverse therapies and imaging applications. These characteristics originate from the building blocks of MOFs, which are metallic ions or clusters and organic constituents. This paper outlines a systematic path, beginning with the history, principles, and mechanism of PDT in cancer therapy. Since combining MOF-based PDT with other treatment modalities has shown promising results in preclinical studies, further optimization of these combination strategies is needed to maximize the therapeutic efficacy. So, the novelty of this review stems from the comprehensive systematic exploration of the recent advances of MOFs- and nMOFs-based PDT in cancer mono- and multi-therapy.

Published
2024
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287. Towards the preparation of smart drug delivery platforms for colorectal cancer therapy: Biocompatible and targeted mesoporous silica nanoparticles with the deferiprone-copper complex gatekeeper

Author

Iranpour, Sonia, Abnous, Khalil, Taghdisi, Seyed Mohammad, and Saljooghi, Amir Sh

Abstract

Achieving smart drug release and preventing premature leakage throughout the delivery journey are two crucial factors that are essential to take into account in the design of nanocarriers. Mesoporous silica nanoparticles (MSNs) can be modified with gatekeeper molecules to achieve controlled release behavior, making them highly promising nanocarriers for smart drug delivery purposes.

Published
2024
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288. The effects of protamine deficiency on ultrastructure of human sperm nucleus

Author

Farhad Golshan Iranpour

Subjects
Chromatin, chromomycinA3, spermatozoa, ultrastructure, Medicine, Biology (General), QH301-705.5
Abstract

Background: Chromomycin A3 (CMA3) staining is one of the staining methods for detecting protamine deficiency in sperm nucleus. CMA3 is a fluorochrome that competes with protamines for binding to DNA double helix. It has been shown in our previous studies that percentage of CMA3 positive spermatozoa in semen has a close significant relationship with the fertilization rate in in vitro fertilization (IVF). The aim of this study was to examine the ultrastructural differences between sperms in patients who had high fluorescent percentages of yellow or red in CMA3 staining (protamine deficient) with patients with low fluorescent percentages. Materials and Methods: Semen samples are taken from five patients with high fluorescent percentages and five patients with low fluorescent percentages. Then the samples are passed for the different steps of preparing for electron microscopy. After the sectioning and mounting on grids, they are investigated under the transmission electron microscope. Results: Sperms in patients with low percentages of positive spermatozoa often have a normal appearance. Sperms in high fluorescent samples frequently have unpacked chromatin. Furthermore acrosomes of these sperms are thinner or disturbed. Also sometimes there are irregularities in sperm head membrane. Conclusion: Protamine deficiency in sperm nucleus can cause ultrastructural anomalies in sperm chromatin such as unpacking of it. It also is concomitant with acrosome and sperm membrane disturbances.

Published
2014
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289. Impact of sperm chromatin evaluation on fertilization rate in intracytoplasmic sperm injection

Author

Farhad Golshan Iranpour

Subjects
Acridine orange, aniline blue, chromomycin A3, intracytoplasmic sperm injection, sperm, Medicine, Biology (General), QH301-705.5
Abstract

Background: Sperm DNA in human beings and most vertebrates is packed by protamines into highly compact form of chromatin. There are many staining methods to assess sperm chromatin. Three different methods of staining were used simultaneously in this study and the goal was to determine which of these sperm tests has a relation with fertilization rate in intracytoplasmic sperm injection (ICSI). Materials and Methods: Thirty couples who referred to Yamagata University Hospital (Yamagata, Japan) for ICSI were included in this study. The greater part of semen was prepared for ICSI. The remaining part was used for staining with aniline blue, acridine orange, and chromomycin A3 (CMA3). For evaluation of abnormal morphology and abnormality of head, Papanicolaou-stained smears were used. The analysis of data was done using Spearman coefficient of correlation and logistic regression model. Receiver operator characteristic (ROC) curve was used for discrimination of CMA3 staining power to identify ICSI rates. Results: Percentage of CMA3 positivity, unlike those of aniline blue and acridine orange, showed significant negative correlation with fertilization rate. Moreover, the percentage of CMA3 positivity showed a positive correlation with the percentage of abnormal morphology and abnormality of head. By dividing patients into CMA3 48% groups, the area under the curve was 0.646. Conclusions: CMA3 staining (protamine deficiency) could be considered as a useful tool for evaluation of male fertility prior to infertility treatment.

Published
2014
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292. Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersionsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1mh01461g

Author

Ong, Quy, Mao, Ting, Iranpour Anaraki, Neda, Richter, ukasz, Malinverni, Carla, Xu, Xufeng, Olgiati, Francesca, Silva, Paulo Henrique Jacob, Murello, Anna, Neels, Antonia, Demurtas, Davide, Shimizu, Seishi, and Stellacci, Francesco

Abstract

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles (diameter < 5 nm). Tomograms are reconstructed from tilt-series 2D images. Once the three-dimensional (3D) coordinates for the centres of mass of all of the particles in the sample are determined, we calculate the pair distribution function g(r) and the potential of mean force U(r) without any assumption. Importantly, we show that further quantitative information from 3D tomograms is readily available as the spatial fluctuation in the particles’ position can be efficiently determined. This in turn allows for the prompt derivation of the Kirkwood–Buff integrals with all their associated quantities such as the second virial coefficient. Finally, the structure factor and the agglomeration states of the particles are evaluated directly. These thermodynamic quantities provide key insights into the dispersion properties of the particles. The method works well both for dispersed systems containing isolated particles and for systems with varying degrees of agglomerations.

Published
2022
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293. Effective microseismic monitoring of the Quest CCS site, Alberta, Canada.

Author

Goertz-Allmann, Bettina P., Langet, Nadège, Iranpour, Kamran, Kühn, Daniela, Baird, Alan, Oates, Steve, Rowe, Carrie, Harvey, Stephen, Oye, Volker, and Nakstad, Hilde

Subjects
SENSOR arrays, CARBON dioxide, INDUCED seismicity
Abstract

Microseismic monitoring represents a key surveillance technology to verify the integrity of subsurface CO 2 storage sites. The precise location of microseismic events is first and foremost a direct and immediate indication of caprock and seal behavior but could also provide insight into CO 2 plume migration. Tiny precursor movements provide diagnostic information about injection-related reservoir and caprock dynamics long before potential seal failure occurs. We present a case study from the Quest CCS facility in Canada, where a variety of different monitoring technologies are employed. We present the different microseismic sensor technologies and array configurations currently installed at the site and compare them against each other with respect to their reliability and effectiveness in providing the required verification information. [ABSTRACT FROM AUTHOR]

Published
2024
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294. Effect of antibacterial photodynamic therapy with chitosan nanoparticles on Aggregatibacter actinomycetemcomitans.

Author

Kamalou, Amir Mohammad, Sayar, Ferena, and Iranpour, Babak

Abstract

• Due to increased number of peri-implantitis cases, it is imperative to find new treatment strategies with higher success rate and low adverse effects. • Recent attention has been placed on non-invasive modalities such as photodynamic therapy (PDT) with different nanoparticles. • PDT with positively charged chitosan nanoparticles (CHNPs) has shown optimally high efficacy for elimination of Gram-negative microorganisms present in peri-implantitis biofilms. • The efficacy of PDT with CHNPs was comparable to that of chlorhexidine (CHX) as the gold-standard against aggregatibacter actinomycetemcomitans , without the known drawbacks of CHX such as cytotoxicity. This study aimed to assess the effect of antibacterial photodynamic therapy (aPDT) with chitosan nanoparticles on Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) in the culture medium. In this in vitro, experimental study, chitosan nanoparticles (CHNPs) containing indocyanine green (ICG) were first synthesized and characterized. A. actinomycetemcomitans was cultured on trypticase soy agar. The culture media containing A. actinomycetemcomitans were randomly subjected to the following six decontamination protocols: negative control subjected to sterile phosphate buffered saline (PBS) for 5 min, positive control exposed to 0.2 % chlorhexidine (CHX) for 5 min, exposure to 0.25 mg/mL ICG in the dark at 37 °C for 5 min, aPDT with 0.25 mg/mL ICG and diode laser (808 nm, 250 mW, 14.94 J/cm2, 30 s, 1 mm distance, 8 mm tip diameter), exposure to CHNPs containing 0.25 mg/mL ICG in the dark at 37 °C for 5 min, and aPDT with CHNPs containing 0.25 mg/mL ICG and diode laser. The number of colonies was counted, and analyzed by one-way ANOVA and Tamhane test (alpha=0.050). Antimicrobial PDT with CHNPs, and CHX groups comparably showed the highest decontamination efficacy (P = 0.000). The results showed optimal efficacy of aPDT with CHNPs containing 0.25 mg/mL ICG and 808 nm diode laser for reduction of A. actinomycetemcomitans colony count. Thus, aPDT appears to be as effective as CHX, but with fewer adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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295. Clinical value of SPECT/CT for evaluation of patients with painful knees after total knee arthroplasty- a new dimension of diagnostics?

Author

Rasch Helmut, Kerner Anna, Iranpour Farhad, Konala Praveen, Hirschmann Michael T, and Friederich Niklaus F

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background The purpose of our study was to evaluate the clinical value of hybrid SPECT/CT for the assessment of patients with painful total knee arthroplasty (TKA). Methods Twenty-three painful knees in patients following primary TKA were assessed using Tc-99m-HDP-SPECT/CT. Rotational, sagittal and coronal position of the TKA was assessed on 3D-CT reconstructions. The level of the SPECT-tracer uptake (0-10) and its anatomical distribution was mapped using a validated localization scheme. Univariate analysis (Wilcoxon-Mann-Whitney, Spearmean`s-rho test, p < 0.05) was performed to identify any correlations between component position, tracer uptake and diagnosis. Results SPECT/CT imaging changed the suspected diagnosis and the proposed treatment in 19/23 (83%) knees. Progression of patellofemoral OA (n = 11), loosening of the tibial (n = 3) and loosening of the femoral component (n = 2) were identified as the leading causes of pain after TKA. Patients with externally rotated tibial trays showed higher tracer uptake in the medial patellar facet (p = 0.049) and in the femur (p = 0.051). Patients with knee pain due to patellofemoral OA showed significantly higher tracer uptake in the patella than others (p < 0.001). Conclusions SPECT/CT was very helpful in establishing the diagnosis and guiding subsequent management in patients with painful knees after TKA, particularly in patients with patellofemoral problems and malpositioned or loose TKA.

Published
2011
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296. An unusual case of persistent groin pain after total hip arthroplasty: a case report

Author

Friederich Niklaus F, Iranpour Farhad, Schaefer Thomas K, Konala Praveen, and Hirschmann Michael T

Subjects
Medicine
Abstract

Abstract Introduction Arthroplasty is a well-established routine elective surgical procedure in orthopaedics. To a great extent, diagnosis, treatment and post-operative rehabilitation in these patients is standardised. In a busy clinic, surgeons from time to time tend to focus their attention on common causes of joint pain, but it may lead them to overlook sinister but less common pathologies. Here we report a case of a patient with groin pain due to pre-operatively undetected pelvic metastases from a pyeloureteral carcinoma who underwent total hip arthroplasty. There are several case reports which deal with primary or secondary tumours which were either discovered at the time of replacement surgery or developed at the site of prosthesis years after total hip or knee replacement. To the best of our knowledge, this is the first case report in which a metastatic cancer was missed pre-operatively and intra-operatively both by the radiologist and by the orthopaedic surgeon and should be reported so that surgeons are reminded to be careful when dealing with seemingly routine cases. Case presentation A 79-year-old Caucasian woman presented to the arthroplasty clinic with groin pain. Initial radiographs showed subtle bilateral abnormalities in the pelvis. Neither the radiologist nor the orthopaedic surgeon recognized it. A diagnosis of osteoarthritis of the hip was established, and she underwent total hip arthroplasty. Despite initial improvement, the patient came back with worsening hip pain three months later. Further radiological examination revealed multiple metastatic lesions throughout the pelvis due to a pyeloureteral carcinoma. Conclusions This case report emphasizes the importance of meticulous, unbiased pre-operative assessment of patients and their radiographs, even in so-called routine clinical cases. Often subtle radiological changes are classed as normal, especially if they are bilateral. Further radiological imaging should be recommended in all cases where unexplained clinical features or radiological findings are present.

Published
2011
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297. A novel method for detection of COVID-19 cases using deep residual neural network

Author

Noshad, Ali, Arjomand, Parham, Khonaksar, Ahmadreza, and Iranpour, Pooya

Abstract

ABSTRACTThe COVID-19 pandemic continues to exert destructive effects on the health and well-being of the global population. Previous studies show that screening helps us identify COVID-19 and provides opportunity to isolate infected patients and put them under treatment. Patients infected with prevalent types of chest infections are frequently misdiagnosed with COVID-19. Motivated by this, in the current study, a novel deep residual COVID-Net architecture for identification of COVID-19 using raw chest X-ray images is presented. According to the results, the proposed model was able to identify COVID-19, pneumonia, and normal cases with a classification accuracy of 99.65%. The proposed model has also demonstrated a superiority in terms of sensitivity, specificity, precision, and f1-score and attained the results of 99%, 99.37%, 99%, and 99%, respectively. Additionally, DRCOVID-Net was validated on the chest X-ray images obtained from 19 patients at Namazi hospital in Iran. It was able to identify 12/13 COVID-19 cases correctly with an accuracy of 84%. The ResNet50 was used as a based architecture in our study. From these experiments and evaluations, we can conclude that the proposed model can reliably be employed to assist radiologists in validating their initial screening and also utilize via cloud as a CAD system.

Published
2021
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298. Application of chloroquine as an endosomal escape enhancing agent: new frontiers for an old drug

Author

Hajimolaali, Mohammad, Mohammadian, Hosein, Torabi, Ali, Shirini, Amin, Khalife Shal, Mostafa, Barazandeh Nezhad, Hami, Iranpour, Sheida, Baradaran Eftekhari, Reza, and Dorkoosh, Farid

Abstract

ABSTRACTIntroductionAdequate transfection efficiency is indispensable to safe and effective delivery of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a critical and determining step devoted a significant number of studies of the drug/gene delivery field.Areas coveredThis paper critically reviews the fundamental properties of chloroquine (CQ), its pharmacokinetics, pharmacodynamics, and clinical applications and the present knowledge of CQ application as an endosomal escape enhancing agent. Different approaches to enhance the endosomal escape process of nanoparticles have been introduced including use of endosomal escape enhancing agents. Application of CQ as either a pre-treatment modality in which cells or animals are exposed to CQ prior to the main treatment or a component of co-delivery systems where CQ and other anti-cancer agents are simultaneously entered the cancer cells, is discussed with recent studies.Expert opinionCQ is founded to intervene with the natural process of endosomal maturation. Moreover, CQ seems to increase the effectiveness of gene delivery by its electrostatic interaction with negatively charged components of the transferred genetic molecules. Endosomal escape might be regarded as the bottleneck of efficient gene delivery and CQ as an effective and available endosomal escape enhancing agent deserves more sophisticated studies.

Published
2021
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299. Representation of Women in the Southern Thoracic Surgical Association: Evidence for Positive Change.

Author

Olive, Jacqueline K., Iranpour, Niki, Luc, Jessica G.Y., Preventza, Ourania A., Blackmon, Shanda H., and Antonoff, Mara B.

Abstract

Despite increases in female representation within the cardiothoracic surgical workforce and societal memberships, our previous work has demonstrated that at the national level, women's roles have remained stagnant among conference presentations and leadership opportunities. In this study, we sought to identify whether similar findings exist at the regional level, specifically within the Southern Thoracic Surgical Association (STSA). STSA Annual Meeting Program Books from 2003, 2008, 2013, and 2018 were reviewed for women's representation among oral abstract authors, invited speakers, moderators, STSA leadership, and award recipients. Differences between the sexes and time points were assessed with χ2 analyses and t tests, respectively. In 2003, women accounted for 4 of 102 authors (3.9%), including 2 of 51 (3.9%) presenting and 2 of 51 (3.9%) senior roles. From 2003 to 2018, increases in female authorship were observed, with 18 of 85 (21.2%) presenting and 13 of 85 (15.3%) senior author positions filled by women (P =.017 and P =.072, respectively). Compared with men, women consistently accounted for fewer invited speakers (P <.050 for all years). Although women represented fewer session moderators (P <.050 for all years), a significant increase was observed over time, from 0 of 2 (0.0%) in 2003 to 18 of 105 (17.1%) in 2018 (P =.009). Compared with 2003, women also increased significantly among STSA committee members in 2018 (0 of 7 [0.0%] vs 6 of 40 [15.0%], P <.001). Over the last 15 years, women have been increasingly represented among STSA Annual Meeting presenting authors, session moderators, and committee members. However, opportunity for greater emphasis on diversity and inclusion exists, particularly among invited speakers and STSA leadership. [ABSTRACT FROM AUTHOR]

Published
2020
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300. Association between caffeine intake and cognitive function in adults; effect modification by sex: Data from National Health and Nutrition Examination Survey (NHANES) 2013–2014.

Author

Iranpour, Sohrab, Saadati, Hossein Mozafar, Koohi, Fatemeh, and Sabour, Siamak

Abstract

The aim of this study was to evaluate the association between caffeine intake and cognitive function. In this cross sectional study, we used data from the 2013–2014 National Health and Nutritional Examination Surveys (NHANES). Our research subjects were 1440 adults aged ≥60 years. The individual's cognitive functions were evaluated using the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word List Learning Test, CERAD Word List Recall Test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). Participants were categorized based on the quartiles of caffeine intake. In each dimension of cognitive, we calculated and used median value as cut-off point and assessed the association between each dimension (binary) and caffeine intake using multiple logistic regression analysis in different models. In all of the dimensions, only the highest quartile of caffeine intakes was positively associated with the cognitive function in the crude model and also trend existed (P trend <0.05). After adjusting for potential confounders (age, sex, family income, education, marital status, history of disease, sleep disorders, thyroid problems, physical activity, social support, smoking, and some nutrients), the association was marginally significant in CERAD Word List Recall Test (P trend = 0.09), but was not significant in other dimensions of cognitive function. A statistically significant interaction was noted between caffeine intake and gender in relation to the CERAD Word List Recall Test (P = 0.02). Generally, there was a weak positive association between caffeine intake and cognitive performance in older adults that modified by sex. So that, the relation was stronger among male than female. [ABSTRACT FROM AUTHOR]

Published
2020
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