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252. Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations

Author

Williams, David, Lafontaine, Anne Louise, Marras, Connie, Jog, Mandar, Panisset, Michael, Lang, Anthony, Parker, Lesley, Stewart, Alistair J., Corvol, Jean-Christophe, Azulay, Jean-Philippe, Couratier, Philippe, Mollenhauer, Brit, Lorenzl, Stefan, Ludolph, Albert, Benecke, Reiner, Hoglinger, Gunter, Lipp, Axel, Reichmann, Heinz, Woitalla, Dirk, Chan, Dennis, Zermansky, Adam, Burn, David, Lees, Andrew, Gozes, Illana, Boxer, Adam, Miller, Bruce L., Lobach, Iryna V., Roberson, Erik, Honig, Lawrence, Zamrini, Edward, Pahwa, Rajesh, Bordelon, Yvette, Driver-Dunkley, Erika, Lessig, Stephanie, Lew, Mark, Womack, Kyle, Boeve, Brad, Ferrara, Joseph, Hillis, Argyle, Kaufer, Daniel, Kumar, Rajeev, Xie, Tao, Gunzler, Steven, Zesiewicz, Theresa, Dayalu, Praveen, Golbe, Lawrence, Grossman, Murray, Jankovic, Joseph, McGinnis, Scott, Santiago, Anthony, Tuite, Paul, Isaacson, Stuart, Leegwater-Kim, Julie, Litvan, Irene, Knopman, David S., Schneider, Lon S., Doody, Rachelle S., Golbe, Lawrence I., Roberson, Erik D., Koestler, Mary, Jack, Clifford R., Jr., Van Deerlin, Viviana, Randolph, Christopher, Whitaker, Steve, Hirman, Joe, Gold, Michael, Morimoto, Bruce H., Nuebling G, Georg, Hensler, Mira, Paul, Sabine, Zwergal, Andreas, Heuer, Hilary W., Tartaglia, Maria C., McGinnis, Scott M., Dickerson, Bradford C., Kornak, John, Schuff, Norbert, Rabinovici, Gil D., Rosen, Howard J., Boxer, Adam L., Gómez, J.C., Tijero, B., Berganzo, K., Garc'ıa de Yebenes, J., Lopez Sendón, J.L., Garcia, G., Tolosa, E., Buongiorno, M.T., Bargalló, N., Burguera, J.A., Martinez, I., Ruiz-Mart'ınez, J., Narrativel, I., Vivancos, F., Ybot, I., Aguilar, M., Quilez, P., Boada, M., Lafuente, A., Hernandez, I., López-Lozano, J.J., Mata, M., Kupsch, A., Lipp, A., Ebersbach, G., Schmidt, T., Hahn, K., Höglinger, G., Höllerhage, M., Oertel, W.H., Respondek, G., Stamelou, M., Reichmann, H., Wolz, M., Schneider, C., Klingelhöfer, L., Berg, D., Maetzler, W., Srulijes, K.K., Ludolph, A., Kassubek, J., Steiger, M., Tyler, K., Burn, D.J., Morris, L., Lees, A., Ling, H., Hauser, R., McClain, T., Truong, D., Jenkins, S., Litvan, I., Houghton, D., Ferrara, J., Bordelon, Y., Gratiano, A., Golbe, L., Mark, M., Uitti, R., Ven Gerpen, J., Brittain, Claire, McCarthy, Andrew, Irizarry, Michael C., McDermott, Dana, Biglan, Kevin, Höglinger, Günter U., and del Ser, Teodoro

Published
2019
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253. Production and propagation of heavy hadrons in air-shower simulators

Author

Canal, C. A. Garcia, Illana, J. I., Masip, M., and Sciutto, S. J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

Very energetic charm and bottom hadrons may be produced in the upper atmosphere when a primary cosmic ray or the leading hadron in an extensive air shower collide with a nucleon. At $E\approx 10^8$ GeV their decay length becomes of the order of 10 km, implying that they tend to interact in the air instead of decaying. Since the inelasticity in these collisions is much smaller than the one in proton and pion collisions, there could be rare events where a heavy-hadron component transports a significant amount of energy deep into the atmosphere. We have developed a module for the detailed simulation of these processes and have included it in a new version of the air shower simulator AIRES. We study the frequency, the energy distribution and the depth of charm and bottom production, as well as the depth and the energy distribution of these quarks when they decay. As an illustration, we consider the production and decay of tau leptons (from $D_s$ decays) and the lepton flux at PeV energies from a 30 EeV proton primary. The proper inclusion of charm and bottom hadrons in AIRES opens the possibility to search for air-shower observables that are sensitive to heavy quark effects., Comment: Accepted for publication in Astroparticle Physics

Published
2012
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254. Supersymmetry with long-lived staus at the LHC

Author

Barcelo, R., Illana, J. I., Masip, M., Prado, A., and Sanchez-Puertas, P.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We consider SUSY extensions of the standard model where the gravitino is the dark-matter particle and the stau is long lived. If there is a significant mass gap with squarks and gluinos, the staus produced at hadron colliders tend to be fast (beta>0.8), and the searches based on their delay in the time of flight or their anomalous ionization become less effective. Such staus would be identified as regular muons with the same linear momentum and a slightly reduced energy. Compared to the usual SUSY models where a neutralino is the LSP, this scenario implies (i) more leptons (the two staus at the end of the decay chains), (ii) a strong e-mu asymmetry, and (iii) less missing E_T (just from neutrinos, as the lightest neutralino decays into stau). We study the bounds on this SUSY from current LHC analyses (same-sign dileptons and multilepton events) and discuss the best strategy for its observation., Comment: 15 pages

Published
2012
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255. Evidence of nuclear disks in starburst galaxies from their radial distribution of supernovae

Author

Herrero-Illana, R., Pérez-Torres, M. A., and Alberdi, A.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Galaxy-galaxy interactions are expected to be responsible for triggering massive star formation and possibly accretion onto a supermassive black hole, by providing large amounts of dense molecular gas down to the central kiloparsec region. Several scenarios to drive the gas further down to the central ~100 pc, have been proposed, including the formation of a nuclear disk around the black hole, where massive stars would produce supernovae. Here, we probe the radial distribution of supernovae and supernova remnants in the nuclear regions of the starburst galaxies M82, Arp 299-A, and Arp 220, by using high-angular resolution (< 0."1) radio observations published in the literature (for M82 and Arp 220), or obtained by ourselves from the European VLBI Network (Arp 299-A). Our main goal was to characterize the nuclear starbursts in those galaxies and thus test scenarios that propose that nuclear disks of sizes ~100 pc form in the central regions of starburst galaxies. We obtained the radial distribution of supernovae (SNe) in the nuclear starbursts of M82, Arp 299-A, and Arp 220, and derived scale-length values for the putative nuclear disks powering the bursts in those central regions. The scale lengths for the (exponential) disks range from ~20-30 pc for Arp 299-A and Arp 220, up to ~140 pc for M82. The radial distribution of SNe for the nuclear disks in Arp 299-A and Arp 220 is also consistent with a power-law surface density profile of exponent gamma=1, as expected from detailed hydrodynamical simulations of nuclear disks. Our results support scenarios where a nuclear disk of size ~100 pc is formed in (U)LIRGs, and sustained by gas pressure, in which case the accretion onto the black hole could be lowered by supernova feedback., Comment: Accepted for publication in Astronomy and Astrophysics

Published
2012
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256. The nuclear starburst in Arp 299-A: From the 5.0 GHz VLBI radio light-curves to its core-collapse supernova rate

Author

Bondi, M., Perez-Torres, M. A., Herrero-Illana, R., and Alberdi, A.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The nuclear region of the Luminous Infra-red Galaxy Arp 299-A hosts a recent ($\simeq 10$ Myr), intense burst of massive star formation which is expected to lead to numerous core-collapse supernovae (CCSNe). Previous VLBI observations, carried out with the EVN at 5.0 GHz and with the VLBA at 2.3 and 8.4 GHz, resulted in the detection of a large number of compact, bright, non-thermal sources in a region $\lsim$150 pc in size. We aim at establishing the nature of all non-thermal, compact components in Arp 299-A, as well as estimating its core-collapse supernova rate. We use multi-epoch European VLBI Network (EVN) observations taken at 5.0 GHz to image with milliarcsecond resolution the compact radio sources in the nuclear region of Arp 299-A. We also use one single-epoch 5.0 GHz Multi-Element Radio Linked Interferometer Network (MERLIN) observation to image the extended emission in which the compact radio sources --traced by our EVN observations-- are embedded. Twenty-six compact sources are detected, 8 of them are new objects not previously detected. The properties of all detected objects are consistent with them being a mixed population of CCSNe and SNRs. We find clear evidence for at least two new CCSNe, implying a lower limit to the CCSN rate of $\nu_{\rm SN}\gsim$0.80 SN/yr indicating that the bulk of the current star formation in Arp 299-A is taking place in the innermost $\sim 150$ pc. Our MERLIN observations trace a region of diffuse, extended emission which is co-spatial to the region where all compact sources are found. From this diffuse, non-thermal radio emission we obtain an independent estimate for the core-collapse supernova rate, which is in the range $\nu_{\rm SN}=0.40$ - 0.65 SN/yr, roughly in agreement with previous estimates and our direct estimate of the CCSN rate from the compact radio emission., Comment: 13 pages, 5 figures, accepted for publication on Astronomy & Astrophysics

Published
2012
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257. An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease

Author

Biljman, Katarina, Gozes, Illana, Lam, Jacqueline CK, and Li, Victor OK

Abstract

Elucidating Alzheimer's disease (AD) prodromal symptoms can resolve the outstanding challenge of early diagnosis. Based on intrinsically related substrates of olfaction and spatial navigation, we propose a novel experimental framework for their conjoint study. Artificial intelligence-driven multimodal study combining self-collected olfactory and motion data with available big clinical datasets can potentially promote high-precision early clinical screenings to facilitate timely interventions targeting neurodegenerative progression.

Published
2024
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259. Propagation of B mesons in the atmosphere

Author

Bueno, A., Gascon, A., Illana, J. I., and Masip, M.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Collisions of cosmic rays in the atmosphere may produce heavy hadrons of very high energy. The decay length of a $B$ meson of energy above $10^7$ GeV is larger than 1 km, implying that such a particle tends to interact in the air before it decays. We show that the fraction of energy deposited in these interactions is much smaller than in proton and pion collisions. We parameterize their elasticity and determine the average number of interactions and the atmospheric depth at the decay point for different initial energies. We find that the profile of a $3\times 10^9$ GeV bottom shower may be very different from the profile of a proton shower of the same energy, defining either a very deep maximum, or two maxima, or other features that cannot be parameterized with a single Gaisser-Hillas function. Finally, we discuss under what conditions a bottom hadron inside the parent air shower may provide observable effects., Comment: 13 pages, 8 figures

Published
2011
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260. Lepton flavor violation in the Simplest Little Higgs model

Author

del Aguila, F., Illana, J. I., and Jenkins, M. D.

Subjects
High Energy Physics - Phenomenology
Abstract

The flavor sector of Little Higgs models based on product groups, notably the Littlest Higgs with T parity (LHT), has been extensively studied and some amount of fine tuning was found to be required to meet the experimental constraints. However, no such attention has been paid to other classes of models. Here we analyze the phenomenology of flavor mixing in the lepton sector of a simple group model, the Simplest Little Higgs (SLH). We obtain the Feynman rules of the SLH in the 't Hooft-Feynman gauge up to the necessary order and calculate the leading contributions to the rare processes mu -> e gamma, mu -> eee and mu-e conversion in nuclei. We find results comparable to those of the LHT model, because in both cases they arise at the one-loop level. These require the flavor alignment of the Yukawa couplings of light and heavy leptons at the per cent level or an effective scale of around 10 TeV., Comment: 41 pages, 8 figures; minor changes and one reference added, version to appear in JHEP

Published
2011
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261. Atmospheric lepton fluxes at very high energy

Author

Illana, J. I., Lipari, Paolo, Masip, M., and Meloni, D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

The observation of astrophysical neutrinos requires a detailed understanding of the atmospheric neutrino background. Since neutrinos are produced in meson decays together with a charged lepton, important constraints on this background can be obtained from the measurement of the atmospheric muon flux. Muons, however, can also be produced as mu+ mu- pairs by purely electromagnetic processes. We use the Z-moment method to study and compare the contributions to the atmospheric muon and neutrino fluxes from different sources (pi/K decay, charmed and unflavored hadron decay, and photon conversion into a muon pair). We pay special attention to the contribution from unflavored mesons (eta, eta', rho0, omega and phi). These mesons are abundant in air showers, their lifetimes are much shorter than those of charged pions or kaons, and they have decay branching ratios of order 10^-4 into final states containing a muon pair. We show that they may be the dominant source of muons at E_mu >10^3 TeV., Comment: Pdflatex, 28 pages, 6 figures

Published
2010
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262. Propagation in the atmosphere of ultrahigh-energy charmed hadrons

Author

Barcelo, R., Illana, J. I., Jenkins, M. D., and Masip, M.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Charmed mesons may be produced when a primary cosmic ray or the leading hadron in an air shower collide with an atmospheric nucleon. At energies \ge 10^8 GeV their decay length becomes larger than 10 km, which implies that they tend to interact in the air instead of decaying. We study the collisions of long-lived charmed hadrons in the atmosphere. We show that (\Lambda_c,D)-proton diffractive processes and partonic collisions of any q^2 where the charm quark is an spectator have lower inelasticity than (p,\pi)-proton collisions. In particular, we find that a D meson deposits in each interaction just around 55% of the energy deposited by a pion. On the other hand, collisions involving the valence c quark (its annihilation with a sea cbar quark in the target or c-quark exchange in the t channel) may deposit most of D meson energy, but their frequency is low (below 0.1% of inelastic interactions). As a consequence, very energetic charmed hadrons may keep a significant fraction of their initial energy after several hadronic interactions, reaching much deeper in the atmosphere than pions or protons of similar energy., Comment: 13 pages, version to appear in PRD

Published
2010
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263. One-loop flavor change in Little Higgs models

Author

Illana, Jose I. and Jenkins, Mark D.

Subjects
High Energy Physics - Phenomenology
Abstract

The Little Higgs (LH) idea attempts to cure the little amount of fine-tuning necessary to bridge the gap between the Higgs mass (electroweak scale) and the new physics scale suggested by electroweak precision tests (~10 TeV). However, we show that LH models do not survive the confrontation with experimental limits on lepton flavor mixing, assuming the same naturalness arguments that motivate their introduction. Two different LH models are analyzed and several aspects of their one-loop predictions for lepton flavor-changing processes are discussed., Comment: 6 pages, 1 figure; contribution to Loops and Legs in Quantum Field Theory, Woerlitz, Germany, April 25-30, 2010

Published
2010
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264. Muon to electron conversion in the Littlest Higgs model with T-parity

Author

del Aguila, F., Illana, J. I., and Jenkins, M. D.

Subjects
High Energy Physics - Phenomenology
Abstract

Little Higgs models provide a natural explanation of the little hierarchy between the electroweak scale and a few TeV scale, where new physics is expected. Under the same inspiring naturalness arguments, this work completes a previous study on lepton flavor-changing processes in the Littlest Higgs model with T-parity exploring the channel that will eventually turn out to be the most sensitive, \mu-e conversion in nuclei. All one-loop contributions are carefully taken into account, results for the most relevant nuclei are provided and a discussion of the influence of the quark mixing is included. The results for the Ti nucleus are in good agreement with earlier work by Blanke et al., where a degenerate mirror quark sector was assumed. The conclusion is that, although this particular model reduces the tension with electroweak precision tests, if the restrictions on the parameter space derived from lepton flavor violation are taken seriously, the degree of fine tuning necessary to meet these constraints also disfavors this model., Comment: 26 pages, 7 figures, 4 tables; discussion improved, results unchanged, one reference added, version to appear in JHEP

Published
2010
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265. Lepton Flavor Violation in Little Higgs Models

Author

Jenkins, Mark D. and Illana, Jose Ignacio

Subjects
High Energy Physics - Phenomenology
Abstract

We report on our study of the LFV processes \mu \to e\gamma, \mu\to eee and \mu \to e conversion in the context of Little Higgs models. Specifically we examine the Littlest Higgs with T-parity (LHT) and the Simplest Little Higgs (SLH) as examples of a Product group and Simple group Little Higgs models respectively. The necessary Feynman rules for both models are obtained in the 't Hooft Feynman Gauge up to order v^2/f^2 and predictions for the branching ratios and conversion rates of the LFV processes are calculated to leading order (one-loop level). Comparison with current experimental constraints show that there is some tension and, in order to be within the limits, one requires a higher breaking scale f, alignment of the heavy and light lepton sectors or almost degenerate heavy lepton masses. These constraints are more demanding in the SLH than in the LHT case., Comment: 6 pages, 3 figures, to appear in Proceedings of the XXXIII Intl. Conf. of Theoretical Physics, "Matter to the Deepest", Ustron, Poland, September 11-16, 2009; v2: comments and references added

Published
2009

266. Atmospheric lepton fluxes at ultrahigh energies

Author

Illana, J. I., Masip, M., and Meloni, D.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

In order to estimate the possibility to observe exotic physics in a neutrino telescope, it is essential to first understand the flux of atmospheric neutrinos, muons and dimuons. We study the production of these leptons by high-energy cosmic rays. We identify three main sources of muons of energy E > 10^6 GeV: the weak decay of charm and bottom mesons and the electromagnetic decay of unflavored mesons. Contrary to the standard assumption, we find that eta mesons, not the prompt decay of charm hadrons, are the dominant source of atmospheric muons at these energies. We show that, as a consequence, the ratio between the neutrino and muon fluxes is significantly reduced. For dimuons, which may be a background for long-lived staus produced near a neutrino telescope, we find that pairs of E ~ 10^7 GeV forming an angle above 10^-6 rad are produced through D (80%) or B (10%) meson decay and through Drell-Yan proceses (10%). The frequency of all these processes has been evaluated using the jet code PYTHIA., Comment: 10 pages, 4 figures; published version

Published
2009
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267. A multi-country analysis of COVID-19 hospitalizations by vaccination status

Author

Goncalves, B, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, L, Piubelli, C, Citarella, B, Kartsonaki, C, Lefevre, B, Lopez Revilla, J, Lunn, M, Harrison, E, Kraemer, M, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, P, Merson, L, Abdukahil, S, Jabal, K, Salah, N, Airlangga, E, Hssain, A, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Anchan, A, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, E, Atique, A, Atlowly, M, Bach, B, Baillie, J, Baird, J, Balan, V, Barbalho, R, Barbosa, N, Barclay, W, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. 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C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., Zambon M., Goncalves, B, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, L, Piubelli, C, Citarella, B, Kartsonaki, C, Lefevre, B, Lopez Revilla, J, Lunn, M, Harrison, E, Kraemer, M, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, P, Merson, L, Abdukahil, S, Jabal, K, Salah, N, Airlangga, E, Hssain, A, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Anchan, A, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, E, Atique, A, Atlowly, M, Bach, B, Baillie, J, Baird, J, Balan, V, Barbalho, R, Barbosa, N, Barclay, W, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, F, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, B, Monteiro, F, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, I, Caceres, E, Garces, R, Campisi, J, Canepa, C, Caoili, J, Cardellino, C, Cardoso, F, Cardoso, S, Carney, G, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castaneda, S, Castanheira, N, Cattaneo, P, Cavalin, R, Cavayas, A, Cevik, M, Chaleunphon, B, Chan, A, Chand, M, Chen, A, Cheng, M, Chommanam, D, Chow, Y, Christy, N, Claure-Del Granado, R, Clohisey, S, Codan, C, Connor, M, Cooke, G, Copland, M, Corley, A, Cortegiani, A, Crowl, G, Cruz, C, Csete, M, Custodio, P, da Silva Filipe, A, Dagens, A, Daley, P, Dalloul, Z, Dalton, H, Dalton, J, Damas, J, Daneman, N, Dankwa, E, Dantas, J, D'Aragon, F, De Rose, C, de Silva, T, Dechert, W, Denis, E, Dishon, Y, K, D, Docherty, A, Donnelly, C, Donohue, C, Douangdala, P, Douglas, J, Downer, T, Downing, M, Drake, T, Dryden, M, Dubot-Peres, A, Dudman, S, Dunning, J, Duplaix, M, Durham, L, Dyrhol-Riise, A, Edelstein, M, Escher, M, Esperatti, M, Santo, C, Estevao, J, Faheem, A, Fairfield, C, Faria, P, Farshait, N, Fernandes, J, Fernandes, M, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fletcher, T, Flynn, B, Fontela, P, Forsyth, S, Foti, G, Fowler, R, Franch-Llasat, D, Fraser, C, Fraser, J, Ribeiro, A, Friedrich, C, Fuentes, N, G, A, Skeie, L, Gamble, C, Garcia-Diaz, J, Garcia-Gallo, E, Gavin, A, Germano, N, Ghadimi, M, Ghisulal, P, Giani, M, Gibson, J, Girvan, M, Goco, G, Gomez-Junyent, J, Grable, M, Green, C, Greenhalf, W, Griffiths, F, Gruner, H, Gu, Y, Guerguerian, A, Guerreiro, D, Haber, D, Habraken, H, Hafez, W, Hall, M, Halpin, S, Hamdan, S, Hamers, R, Hamza, S, Hardwick, H, Harrison, J, Hartman, A, Heggelund, L, Hendry, R, Hennessy, M, Hesstvedt, L, Higgins, D, Higgins, R, Hinton, S, Ho, A, Holter, J, Horcajada, J, Ming-Yang Hsu, J, Hurd, A, Ijaz, S, Illana, C, Inacio, H, Ippolito, M, Isidoro, T, Jaber, H, Jackson, C, Jaworsky, D, Jenum, S, Jouvet, P, Kalicinska, A, Kandel, C, Katz, K, Kaur, A, Keating, S, Kelly, A, Kelly, S, Kennon, K, Keomany, S, Khalid, I, Kho, M, Khoo, S, Kiiza, P, Granerud, B, Kildal, A, Klenerman, P, Bekken, G, Knight, S, Korten, V, Kosgei, C, Kumar, D, Kutsogiannis, D, Lamontagne, F, Lanza, M, Law, A, Lawrence, T, Lee, J, Lee, T, Leeming, G, Letizia, A, Bassi, G, Liang, J, Lim, W, Lind, A, Lissauer, S, Lopes, D, Lyons, R, Machado, S, Majeed, N, Manetta, F, Sant`Ana Malaque, C, Marquis, C, Marsh, L, Marshall, J, Martin-Quiros, A, Martins, A, Rego, C, Martucci, G, Maslove, D, Matthew, C, Mayxay, M, Mcarthur, C, Mccarthy, A, Mcconnochie, R, Mcdonald, S, Mcgeer, A, Mckay, C, Mclean, K, Menon, K, Mentzer, A, Mesquita, A, Meyer, D, Meynert, A, Mihelis, E, Monteiro, A, Montrucchio, G, Moore, S, Cely, L, Moro, L, Morton, B, Mudara, C, Muhaisen, M, Muller, F, Muller, K, Munshi, L, Murthy, S, Mustafa, D, Nagpal, D, Narasimhan, M, Nasa, P, Nelder, M, Neumann, E, Ng, P, Nichol, A, Norman, L, Notari, A, Noursadeghi, M, Nusantara, D, Occhipinti, G, O'Hearn, K, Oliveira, L, Ong, D, Oosthuyzen, W, Openshaw, P, Palmarini, M, Panarello, G, Panda, P, Parke, R, Patricio, P, Patterson, L, Paul, M, Paulos, J, Paxton, W, Pejkovska, M, Pereira, R, Petrovic, M, Pettersen, F, Pharand, S, Phonemixay, O, Phoutthavong, S, de Piero, M, Pimentel, C, Pires, C, Pitaloka, A, Pius, R, Poli, S, Pollakis, G, Post, A, Povoas, D, Powis, J, Praphasiri, V, Pritchard, M, Semedi, B, Purcell, G, Quesada, L, Quist-Paulsen, E, Rafael, A, Rahardjani, M, Ramalho, J, Rangappa, R, Ratsep, I, Reeve, B, Reikvam, D, Ren, H, Rewa, O, Ricchiuto, A, Rishu, A, Rivera Nunez, M, Roberts, S, Robertson, D, Roche-Campo, F, Rodari, P, Roessler, B, Rossanese, A, Rossetti, M, Russell, C, Holten, A, Saba, I, Sadat, M, Sahraei, V, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Sandulescu, O, Santos, M, Sarfo-Mensah, S, Sarmiento, I, Saviciute, E, Schaffer, J, Schwameis, M, Schwartz, G, Scott, J, Scott-Brown, J, Semple, M, Sequeira, T, Shadowitz, E, Shankar, A, Shaw, C, Shaw, V, Mohan Shetty, D, Sibounheuang, B, Sigfrid, L, Sillaots, P, Sin, W, Sinatti, D, Singh, M, Skogen, V, Smith, S, Solomon, J, Solomon, T, Song, R, Spinuzza, E, Sriskandan, S, Staudinger, T, Stecher, S, Steinsvik, T, Stiksrud, B, Streinu-Cercel, A, Stuart, D, Subekti, D, Suen, J, Sultana, A, Summers, C, Suwarti, A, Sztajnbok, J, Tabrizi, S, Taleb, S, Tedder, R, Teixeira, J, Tessier-Grenier, H, Thompson, S, Thomson, E, Thorpe, M, Thwaites, R, Tonby, K, Torre, M, Torres Santos-Olmo, R, Turgeon, A, Turtle, L, Tveita, A, Twardowski, P, Ullrich, R, Uyeki, T, Valentini, P, Val-Flores, L, Varrone, M, Vidal, J, Vieira, C, Villanueva, J, Villar, J, Villoldo, A, Vitiello, C, Vongsouvath, M, Wainstein, M, Webb, S, Wei, J, Wesselius, S, Wham, M, White, N, Willems, S, Williams, B, Williams, V, Wils, E, Wittman, J, Yerkovich, S, Yiaye, T, Zahran, M, Zambon, M, Goncalves B. P., Jassat W., Baruch J., Hashmi M., Rojek A., Dasgupta A., Martin-Loeches I., Reyes L. F., Piubelli C., Citarella B. W., Kartsonaki C., Lefevre B., Lopez Revilla J. W., Lunn M., Harrison E. M., Kraemer M. U. G., Shrapnel S., Horby P., Bisoffi Z., Olliaro P. L., Merson L., Abdukahil S. A., Jabal K. A., Salah N. A., Airlangga E., Hssain A. A., Akwani C., Al Qasim E., Alberti A., Aldabbourosama O., Alessi M., Alex B., Al-Fares A., Aliudin J., Alkahlout M., Almasri L., Al-Saba'a Y., Alves R., Cabrita J. A., Amaral M., Ampaw P., Anchan A. J., Angheben A., Arabi Y., Arcadipane A., Archambault P., Arenz L., Arora R., Ashley E. A., Atique A., Atlowly M., Bach B., Baillie J. K., Baird J. K., Balan V., Barbalho R., Barbosa N. Y., Barclay W. S., Barnikel M., Beer N., Begum H., Bellemare D., Beltrame A., Bertoli G., Bianco C., Humaid F. B., Bitton J., Blier C., Bogaert D., Borges D., Bouhmani D., Bounphiengsy T., Bountthasavong L., Klerk B. B. -D., Monteiro F. B., Brazzi L., Buchtele N., Buonsenso D., Burrell A., Bustos I. G., Cabrita J., Caceres E., Garces R. C., Campisi J., Canepa C., Caoili J., Cardellino C. S., Cardoso F., Cardoso S., Carney G., Carrier F. M., Carson G., Cascao M., Casimiro J., Castaneda S., Castanheira N., Cattaneo P., Cavalin R., Cavayas A., Cevik M., Chaleunphon B., Chan A., Chand M., Chen A., Cheng M. P., Chommanam D., Chow Y. P., Christy N., Claure-Del Granado R., Clohisey S., Codan C., Connor M., Cooke G. S., Copland M., Corley A., Cortegiani A., Crowl G., Cruz C., Csete M., Custodio P., da Silva Filipe A., Dagens A., Daley P., Dalloul Z., Dalton H., Dalton J., Damas J., Daneman N., Dankwa E. A., Dantas J., D'Aragon F., De Rose C., de Silva T., Dechert W., Denis E., Dishon Y., k Dhangar, Docherty A. B., Donnelly C. A., Donohue C., Douangdala P., Douglas J. J., Downer T., Downing M., Drake T., Dryden M., Dubot-Peres A., Dudman S., Dunning J., Duplaix M., Durham L., Dyrhol-Riise A. M., Edelstein M., Escher M., Esperatti M., Santo C. E., Estevao J., Faheem A., Fairfield C. J., Faria P., Farshait N., Fernandes J., Fernandes M. A., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fletcher T., Flynn B., Fontela P., Forsyth S., Foti G., Fowler R. A., Franch-Llasat D., Fraser C., Fraser J. F., Ribeiro A. F., Friedrich C., Fuentes N., G A., Skeie L. G., Gamble C., Garces R., Garcia-Diaz J., Garcia-Gallo E., Gavin A., Germano N., Ghadimi M., Ghisulal P. K., Giani M., Gibson J., Girvan M., Goco G., Gomez-Junyent J., Grable M., Green C. A., Greenhalf W., Griffiths F., Gruner H., Gu Y., Guerguerian A. -M., Guerreiro D., Haber D., Habraken H., Hafez W., Hall M., Halpin S., Hamdan S., Hamers R. L., Hamza S., Hardwick H., Harrison J., Hartman A., Heggelund L., Hendry R., Hennessy M., Hesstvedt L., Higgins D., Higgins R., Hinton S., Ho A., Holter J. C., Horcajada J. P., Ming-Yang Hsu J., Hurd A., Ijaz S., Illana C. C., Inacio H., Ippolito M., Isidoro T., Jaber H., Jackson C., Jaworsky D., Jenum S., Jouvet P., Kalicinska A., Kandel C., Katz K., Kaur A., Keating S., Kelly A., Kelly S., Kennon K., Keomany S., Khalid I., Kho M. E., Khoo S., Kiiza P., Granerud B. K., Kildal A. B., Klenerman P., Bekken G. K., Knight S. R., Korten V., Kosgei C., Kumar D., Kutsogiannis D., Lamontagne F., Lanza M., Law A., Lawrence T., Lee J., Lee T. C., Leeming G., Letizia A., Bassi G. L., Liang J., Lim W. S., Lind A., Lissauer S., Lopes D., Lyons R., Machado S., Majeed N. A., Manetta F., Sant`Ana Malaque C. M., Marquis C., Marsh L., Marshall J., Martin-Quiros A., Martins A., Rego C. M., Martucci G., Maslove D., Matthew C., Mayxay M., McArthur C., McCarthy A., McConnochie R., McDonald S. E., McGeer A., McKay C., McLean K. A., Menon K., Mentzer A. J., Mesquita A., Meyer D., Meynert A. M., Mihelis E., Monteiro A., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Morton B., Mudara C., Muhaisen M., Muller F., Muller K. E., Munshi L., Murthy S., Mustafa D., Nagpal D., Narasimhan M., Nasa P., Nelder M., Neumann E., Ng P. Y., Nichol A. D., Norman L., Notari A., Noursadeghi M., Nusantara D. U., Occhipinti G., O'Hearn K., Oliveira L., Ong D. S. Y., Oosthuyzen W., Openshaw P., Palmarini M., Panarello G., Panda P. K., Parke R., Patricio P., Patterson L., Paul M., Paulos J., Paxton W. A., Pejkovska M., Pereira R., Petrovic M., Pettersen F. O., Pharand S., Phonemixay O., Phoutthavong S., de Piero M., Pimentel C., Pires C., Pitaloka A., Pius R., Poli S., Pollakis G., Post A. -M., Povoas D., Powis J., Praphasiri V., Pritchard M. G., Semedi B. P., Purcell G., Quesada L., Quist-Paulsen E., Rafael A., Rahardjani M., Ramalho J., Rangappa R., Ratsep I., Reeve B., Reikvam D. H., Ren H., Rewa O., Ricchiuto A., Rishu A., Rivera Nunez M. A., Roberts S., Robertson D. L., Roche-Campo F., Rodari P., Roessler B., Rossanese A., Rossetti M., Russell C. D., Holten A. R., Saba I., Sadat M., Sahraei V., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Sandulescu O., Santos M., Sarfo-Mensah S., Sarmiento I. C. E., Saviciute E., Schaffer J., Schwameis M., Schwartz G., Scott J. T., Scott-Brown J., Semple M. G., Sequeira T., Shadowitz E., Shankar A., Shaw C. A., Shaw V., Mohan Shetty D. R., Sibounheuang B., Sigfrid L., Sillaots P., Sin W. C., Sinatti D., Singh M., Skogen V., Smith S., Solomon J., Solomon T., Song R., Spinuzza E., Sriskandan S., Staudinger T., Stecher S. -S., Steinsvik T., Stiksrud B., Streinu-Cercel A., Stuart D., Subekti D., Suen J. Y., Sultana A., Summers C., Suwarti A., Sztajnbok J., Tabrizi S., Taleb S., Tedder R. S., Teixeira J., Tessier-Grenier H., Thompson S., Thomson E. C., Thorpe M., Thwaites R. S., Tonby K., Torre M., Torres Santos-Olmo R. M., Turgeon A. F., Turtle L. C. W., Tveita A., Twardowski P., Ullrich R., Uyeki T. M., Valentini P., Val-Flores L., Varrone M., Vidal J. E., Vieira C., Villanueva J. A., Villar J., Villoldo A., Vitiello C., Vongsouvath M., Wainstein M., Webb S., Wei J., Wesselius S., Wham M., White N., Willems S., Williams B., Williams V., Wils E. -J., Wittman J., Yerkovich S., Yiaye T., Zahran M., and Zambon M.

Abstract

Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.

Published
2023

268. Discovery and characterization of potent and selective SARS-CoV-2 antivirals with pan-coronavirus potential

Author

European Commission, Cabrera-Torrejón, Daniel [0000-0002-5353-7675], Castro-Navas, Francisco F. [0000-0002-3245-7158], Castro Illana, Victoria [0000-0001-9151-5138], Moya Vaquero, Jennifer [0000-0003-4569-4678], Barrera, Javier Luis [0000-0002-3438-6955], Calvo Gutierrez, Gema [0000-0002-9208-1340], Martín-Acebes, M. A. [0000-0001-6015-3613], Cabrera-Torrejón, Daniel, Bueno, P., Castro-Navas, Francisco F., Castro Illana, Victoria, Cobos, Alvaro, Moya Vaquero, Jennifer, Barrera, Javier Luis, Barbado, Laura, Calvo Gutierrez, Gema, Martín-Acebes, M. A., European Commission, Cabrera-Torrejón, Daniel [0000-0002-5353-7675], Castro-Navas, Francisco F. [0000-0002-3245-7158], Castro Illana, Victoria [0000-0001-9151-5138], Moya Vaquero, Jennifer [0000-0003-4569-4678], Barrera, Javier Luis [0000-0002-3438-6955], Calvo Gutierrez, Gema [0000-0002-9208-1340], Martín-Acebes, M. A. [0000-0001-6015-3613], Cabrera-Torrejón, Daniel, Bueno, P., Castro-Navas, Francisco F., Castro Illana, Victoria, Cobos, Alvaro, Moya Vaquero, Jennifer, Barrera, Javier Luis, Barbado, Laura, Calvo Gutierrez, Gema, and Martín-Acebes, M. A.

Abstract

The latest events caused by the SARS-CoV-2 pandemic highlight the need to develop means to stop the expansion of these pathogens. The use of prophylactic vaccines has considerably reduced the impact of these outbreaks. However, viruses continue to circulate among the population and therapeutic tools are needed to treat infected individuals in the form of effective antivirals. Using a phenotypic screening approach, a new family of antiviral molecules has been identified and a medicinal chemistry program for the generation of preclinical candidates started. Structure-activity and structure-property relationship studies have guided the hit to lead process and allowed the optimization and selection of lead compounds as potent, selective antiviral agents against SARS-CoV-2. The identified antiviral leads show excellent cell culture profiles for further development: i) unequivocal antiviral activity and good therapeutic window, ii) ability to interfere with viral replication even after infection has been initiated (post-entry), iii) selectivity over other (+)-strand RNA viruses and iv) pan-coronavirus potential activity. We have also started to explore the potential pathways leading to compounds resistance, the molecular mechanisms involved, and the viral determinants. Preliminary studies have revealed that the selective pressure imposed by the compounds cluster together in a non-structural region of SARSCoV-2 genome responsible for the formation of double membrane vesicles, the putative RNA replication compartment. To date, no drugs targeting this region has been identified. Overall, our research would represent a significant step forward in developing new, innovative strategies for treating infections caused by emergent coronaviruses.

Published
2023

269. Coulomb excitation of Zn 74,76

Author

European Commission, Research Foundation - Flanders, Federal Ministry of Education and Research (Germany), Ministry of Science and Higher Education (Poland), Ministerio de Ciencia e Innovación (España), National Science Centre (Poland), RIKEN Nishina Center for Accelerator-Based Science, Illana, A. [0000-0003-0274-3388], Zielińska, M. [0000-0001-5622-6349], Van Duppen, P. [0000-0002-5053-7370], Wrzosek-Lipska, K. [0000-0003-0046-1387], Lenzi, S. M. [0000-0002-4666-8431], Nowacki, F. [0000-0002-7854-8717], Dao, D. D. [0000-0001-9884-4591], Otsuka, T. [0000-0002-1593-5322], Tsunoda, Y. [0000-0002-0398-1639], Illana, A., Zielińska, M., Huyse, M., Rapisarda, E., Van Duppen, P., Wrzosek-Lipska, K., Lenzi, S. M., Nowacki, F., Dao, D. D., Otsuka, T., Tsunoda, Y., Arnswald, K., García Borge, María José, Cederkäll, J., Chrysalidis, K., Cortés, M. L., Cox, D. M., Day Goodacre, T., De Witte, H., Doherty, D. T., Fedosseev, V., Gaffney, L. P., Hadyńska-Klek, K., Hess, H., Henrich, C., Hlebowicz, M., Komorowska, M., Korten, W., Kröll, Th, Lozano Benito, M. L., Lutter, R., Marsh, B., Martikainen, L., Matejska-Minda, M., Molkanov, P. L., Nacher, Enrique, Nannini, A., Napiorkowski, P. J., Pakarinen, J., Papadakis, P., Queiser, M., Reiter, P., Rocchini, M., Rodriguez, J. A., Rolke, T., Rosiak, D., Rothe, S., Seidlitz, M., Seiffert, C., Siebeck, B., Siesling, E., Snäll, J., Srebrny, J., Thiel, S., Warr, N., Wenander, F., European Commission, Research Foundation - Flanders, Federal Ministry of Education and Research (Germany), Ministry of Science and Higher Education (Poland), Ministerio de Ciencia e Innovación (España), National Science Centre (Poland), RIKEN Nishina Center for Accelerator-Based Science, Illana, A. [0000-0003-0274-3388], Zielińska, M. [0000-0001-5622-6349], Van Duppen, P. [0000-0002-5053-7370], Wrzosek-Lipska, K. [0000-0003-0046-1387], Lenzi, S. M. [0000-0002-4666-8431], Nowacki, F. [0000-0002-7854-8717], Dao, D. D. [0000-0001-9884-4591], Otsuka, T. [0000-0002-1593-5322], Tsunoda, Y. [0000-0002-0398-1639], Illana, A., Zielińska, M., Huyse, M., Rapisarda, E., Van Duppen, P., Wrzosek-Lipska, K., Lenzi, S. M., Nowacki, F., Dao, D. D., Otsuka, T., Tsunoda, Y., Arnswald, K., García Borge, María José, Cederkäll, J., Chrysalidis, K., Cortés, M. L., Cox, D. M., Day Goodacre, T., De Witte, H., Doherty, D. T., Fedosseev, V., Gaffney, L. P., Hadyńska-Klek, K., Hess, H., Henrich, C., Hlebowicz, M., Komorowska, M., Korten, W., Kröll, Th, Lozano Benito, M. L., Lutter, R., Marsh, B., Martikainen, L., Matejska-Minda, M., Molkanov, P. L., Nacher, Enrique, Nannini, A., Napiorkowski, P. J., Pakarinen, J., Papadakis, P., Queiser, M., Reiter, P., Rocchini, M., Rodriguez, J. A., Rolke, T., Rosiak, D., Rothe, S., Seidlitz, M., Seiffert, C., Siebeck, B., Siesling, E., Snäll, J., Srebrny, J., Thiel, S., Warr, N., and Wenander, F.

Abstract

The first experiment using radioactive beams post-accelerated by the HIE-ISOLDE facility has enabled to obtain a precise set of B(E2) transition probabilities in neutron-rich 74,76Zn isotopes. The resulting B(E2; 21+ → 01+) values are consistent with those determined in earlier REX-ISOLDE measurements. While the B(E2; 41+ → 21+) transition probability in 76Zn is also in agreement with earlier Coulomb-excitation results, the value obtained for 74Zn is considerably lower. For the first time, a spectroscopic quadrupole moment of the 21+ state was measured for an exotic nucleus in this mass region. A detailed comparison is presented with large-scale shell-model and Monte Carlo shell-model calculations.

Published
2023

271. Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment

Author

Cuerda-Ballester, María, primary, Bustos, Antonio, additional, Sancho-Cantus, David, additional, Martínez-Rubio, David, additional, Privado, Jesús, additional, Alarcón-Jiménez, Jorge, additional, Villarón-Casales, Carlos, additional, de Bernardo, Nieves, additional, Navarro Illana, Esther, additional, and de la Rubia Ortí, José Enrique, additional

Published
2024
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273. Magnetic moments of thallium isotopes in the vicinity of magic N = 126

Author

Yue, Z., primary, Andreyev, A.N., additional, Barzakh, A.E., additional, Borzov, I.N., additional, Cubiss, J.G., additional, Algora, A., additional, Au, M., additional, Balogh, M., additional, Bara, S., additional, Bark, R.A., additional, Bernerd, C., additional, Borge, M.J.G., additional, Brugnara, D., additional, Chrysalidis, K., additional, Cocolios, T.E., additional, De Witte, H., additional, Favier, Z., additional, Fraile, L.M., additional, Fynbo, H.O.U., additional, Gottardo, A., additional, Grzywacz, R., additional, Heinke, R., additional, Illana, A., additional, Jones, P.M., additional, Judson, D.S., additional, Korgul, A., additional, Köster, U., additional, Labiche, M., additional, Le, L., additional, Lica, R., additional, Madurga, M., additional, Marginean, N., additional, Marsh, B., additional, Mihai, C., additional, Nácher, E., additional, Neacsu, C., additional, Nita, C., additional, Olaizola, B., additional, Orce, J.N., additional, Page, C.A.A., additional, Page, R.D., additional, Pakarinen, J., additional, Papadakis, P., additional, Penyazkov, G., additional, Perea, A., additional, Piersa-Siłkowska, M., additional, Podolyák, Zs., additional, Prosnyak, S.D., additional, Reis, E., additional, Rothe, S., additional, Sedlak, M., additional, Skripnikov, L.V., additional, Sotty, C., additional, Stegemann, S., additional, Tengblad, O., additional, Tolokonnikov, S.V., additional, Udías, J.M., additional, Van Duppen, P., additional, Warr, N., additional, and Wojtaczka, W., additional

Published
2024
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275. Fast-timing Investigation of \(A=128\) Isobars Populated in the \(\beta \)-decay of \(^{128}\)Cd

Author

Llanos-Expósito, M., primary, Fraile, L.M., additional, Benito, J., additional, Acosta, J., additional, Algora, A., additional, Andel, B., additional, Andreyev, A.N., additional, Antalic, S., additional, Bark, R.A., additional, Bernerd, C., additional, Bernier, N., additional, Bhengu, B., additional, Bittner, D., additional, Borge, M.J.G., additional, Briz, J.A., additional, Chrysalidis, K., additional, Cocolios, T.E., additional, Costache, C., additional, Cubiss, J.G., additional, De Witte, H., additional, Encina, N., additional, Esmaylzadeh, A., additional, Favier, Z., additional, Fernández, D., additional, Ferrera, C., additional, Fynbo, H.O.U., additional, García-Távora, V., additional, Georgiev, G., additional, Górska, M., additional, Heinke, R., additional, Herraiz, J.L., additional, Illana, A., additional, Jones, P., additional, Judson, D.S., additional, Jungclaus, A., additional, Karny, M., additional, Korgul, A., additional, Köster, U., additional, Kröll, Th., additional, Labiche, M., additional, Lalkovski, S., additional, Lesch, B., additional, Ley, M., additional, Lică, R., additional, Madurga, M., additional, Mărginean, N., additional, Marsh, B.A., additional, Miernik, K., additional, Mihai, C., additional, Mikolajczuk, M., additional, Mišt, J., additional, Murias, J.R., additional, Nácher, E., additional, Neacsu, C., additional, Nouvilas, V.M., additional, Ntshangase, S., additional, Olaizola, B., additional, Orce, J.N., additional, Page, C., additional, Pakarinen, J., additional, Papadakis, P., additional, Perea, A., additional, Piersa-Siłkowska, M., additional, Podolyak, Zs., additional, Rog, J., additional, Rothe, S., additional, Rozwoda, B., additional, Sánchez-Tembleque, V., additional, Solak, K., additional, Stegemann, S., additional, Stepaniuk, M., additional, Stoica, A., additional, Stryjczyk, M., additional, Tengblad, O., additional, Turturica, A., additional, Turturica, G., additional, Udías, J.M., additional, Ujeniuc, S., additional, Van Duppen, P., additional, von Tresckow, M., additional, Vasilev, I., additional, Warr, N., additional, Yue, Z., additional, and Zajda, S., additional

Published
2024
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277. A Mediterranean Diet with an Enhanced Consumption of Extra Virgin Olive Oil and Pistachios Improves Pregnancy Outcomes in Women Without Gestational Diabetes Mellitus : A Sub-Analysis of the St. Carlos Gestational Diabetes Mellitus Prevention Study

Author

Assaf-Balut, Carla, de la Torre, Nuria García, Duran, Alejandra, Fuentes, Manuel, Bordiú, Elena, del Valle, Laura, Familiar, Cristina, Valerio, Johanna, Jiménez, Inés, Herraiz, Miguel A., Izquierdo, Nuria, Torrejon, María J., Cuadrado, Maria Ángeles, Ortega, Isabel, Illana, Francisco J., Runkle, Isabelle, de Miguel, Paz, Moraga, Inmaculada, Montañez, Carmen, Barabash, Ana, Cuesta, Martín, Rubio, Miguel A., and Calle-Pascual, Alfonso L.

Published
2019

278. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Author

Boxer, Adam L, Lang, Anthony E, Grossman, Murray, Knopman, David S, Miller, Bruce L, Schneider, Lon S, Doody, Rachelle S, Lees, Andrew, Golbe, Lawrence I, Williams, David R, Corvol, Jean-Cristophe, Ludolph, Albert, Burn, David, Lorenzl, Stefan, Litvan, Irene, Roberson, Erik D, Höglinger, Günter U, Koestler, Mary, Jack, Clifford R, Van Deerlin, Viviana, Randolph, Christopher, Lobach, Iryna V, Heuer, Hilary W, Gozes, Illana, Parker, Lesley, Whitaker, Steve, Hirman, Joe, Stewart, Alistair J, Gold, Michael, Morimoto, Bruce H, and Investigators, for the AL-108-231

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Neurosciences, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Double-Blind Method, Female, Humans, Male, Oligopeptides, Supranuclear Palsy, Progressive, Treatment Outcome, AL-108-231 Investigators, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundIn preclinical studies, davunetide promoted microtubule stability and reduced tau phosphorylation. Because progressive supranuclear palsy (PSP) is linked to tau pathology, davunetide could be a treatment for PSP. We assessed the safety and efficacy of davunetide in patients with PSP.MethodsIn a double-blind, parallel group, phase 2/3 trial, participants were randomly assigned with permuted blocks in a 1:1 ratio to davunetide (30 mg twice daily, intranasally) or placebo for 52 weeks at 48 centres in Australia, Canada, France, Germany, the UK, and the USA. Participants met the modified Neuroprotection and Natural History in Parkinson Plus Syndrome study criteria for PSP. Primary endpoints were the change from baseline in PSP Rating Scale (PSPRS) and Schwab and England Activities of Daily Living (SEADL) scale at up to 52 weeks. All participants and study personnel were masked to treatment assignment. Analysis was by intention to treat. The trial is registered with Clinicaltrials.gov, number NCT01110720.Findings313 participants were randomly assigned to davunetide (n=157) or to placebo (n=156), and 241 (77%) completed the study (118 and 156 in the davunetide and placebo groups, respectively). There were no differences in the davunetide and placebo groups in the baseline PSPRS and SEADL. The davunetide and placebo groups did not differ in the change from baseline in PSPRS (median 11·8 [95% CI 10·5 to 13·0] vs 11·8 [10·5 to 13·0], respectively, p=0·41) or SEADL (-0·20 [-0·20 to -0·17] vs -0·20 [-0·22 to -0·17], respectively, p=0·92). 54 serious adverse events were reported in each of the treatment groups, including 11 deaths in the davunetide group and ten in the placebo group. The frequency of nasal adverse events was greater in the davunetide group than in the placebo group (epistaxis 18 [12%] of 156 vs 13 [8%] of 156, rhinorrhoea 15 [10%] vs eight [5%], and nasal discomfort 15 [10%] vs one [

Published
2014

279. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.

Author

Akbay, Esra, Moslehi, Javid, Christensen, Camilla, Saha, Supriya, Tchaicha, Jeremy, Ramkissoon, Shakti, Stewart, Kelly, Carretero, Julian, Kikuchi, Eiki, Zhang, Haikuo, Cohoon, Travis, Murray, Stuart, Liu, Wei, Uno, Kazumasa, Fisch, Sudeshna, Jones, Kristen, Gurumurthy, Sushma, Gliser, Camelia, Choe, Sung, Keenan, Marie, Son, Jaekyoung, Stanley, Illana, Losman, Julie, Padera, Robert, Bronson, Roderick, Asara, John, Abdel-Wahab, Omar, Amrein, Philip, Fathi, Amir, Danial, Nika, Kimmelman, Alec, Kung, Andrew, Ligon, Keith, Yen, Katharine, Kaelin, William, Bardeesy, Nabeel, and Wong, Kwok-Kin

Subjects
D-2HG, D2HGA, IDH2, cardiomyopathy, glycogen, myopathy, vacuolar leukoencephalopathy, Animals, Cardiomyopathies, Cell Line, Gene Expression Profiling, Gene Expression Regulation, Developmental, Glutarates, Heart, Humans, Isocitrate Dehydrogenase, Mice, Mice, Inbred BALB C, Mice, Nude, Mutation, Neurodegenerative Diseases
Abstract

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2-hydroxyglutaric acid (D-2HG). To study the pathophysiological consequences of the accumulation of D-2HG, we generated transgenic mice with conditionally activated IDH2(R140Q) and IDH2(R172K) alleles. Global induction of mutant IDH2 expression in adults resulted in dilated cardiomyopathy, white matter abnormalities throughout the central nervous system (CNS), and muscular dystrophy. Embryonic activation of mutant IDH2 resulted in more pronounced phenotypes, including runting, hydrocephalus, and shortened life span, recapitulating the abnormalities observed in D2HGA patients. The diseased hearts exhibited mitochondrial damage and glycogen accumulation with a concordant up-regulation of genes involved in glycogen biosynthesis. Notably, mild cardiac hypertrophy was also observed in nude mice implanted with IDH2(R140Q)-expressing xenografts, suggesting that 2HG may potentially act in a paracrine fashion. Finally, we show that silencing of IDH2(R140Q) in mice with an inducible transgene restores heart function by lowering 2HG levels. Together, these findings indicate that inhibitors of mutant IDH2 may be beneficial in the treatment of D2HGA and suggest that 2HG produced by IDH mutant tumors has the potential to provoke a paraneoplastic condition.

Published
2014

280. STUDY OF THE INFLUENCE OF COPPER REINFORCEMENT ON THE TRIBOLOGICAL PROPERTIES OF PARTS OBTAINED BY FUSED FILAMENT FABRICATION.

Author

Batista-Ponce, Moisés, Salguero-Gómez, Jorge, del Sol Illana, Irene, Ramírez-Peña, Magdalena, and Vázquez-Martínez, Juan-Manuel

Subjects
COPPER, FIBERS, MANUFACTURING processes
Abstract

The excellent tribological properties of copper are well known, therefore it is commonly used in components whose tribological characteristics have a high impact. Thanks to the characteristics of Additive Manufacturing it is possible to manufacture parts incorporating copper particles. However, the main mechanical studies are related to performance under tensile-compression or bending conditions and the tribological properties remain understudied and this means that there is no knowledge of the possible performance of parts obtained using additive techniques with these particles. For this reason, this article proposes to carry out a study on a polymeric Additive Manufacturing process, specifically, Fused Filament Manufacturing, which is the most widely used process at present and where it is possible to obtain thermoplastic matrix filaments with different types of reinforcements. In this case, a reinforcement of metallic nature will be chosen, such as copper particles, where the properties of this material will be exploited. The aim is to find out how the basic manufacturing parameters, layer thickness and temperature, influence the tribological behaviour of the parts obtained with this process. [ABSTRACT FROM AUTHOR]

Published
2024
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281. Investigating the impact of Psidium guajava leaf hydroalcoholic extract in improving glutamatergic toxicity-induced oxidative stress in Danio rerio larvae.

Author

Lopes, Andressa Rubim, Costa Silva, Dennis Guilherme, Rodrigues, Nathane Rosa, Kemmerich Martins, Illana, Paganotto Leandro, Luana, Nunes, Mauro Eugênio Medina, Posser, Thais, and Franco, Jeferson

Subjects
GUAVA, ZEBRA danio, OXIDATIVE stress, EXCITATORY amino acid agents, CENTRAL nervous system, LARVAE, NEURODEGENERATION
Abstract

Glutamate is one of the predominant excitatory neurotransmitters released from the central nervous system; however, at high concentrations, this substance may induce excitotoxicity. This phenomenon is involved in numerous neuropathologies. At present, clinically available pharmacotherapeutic agents to counteract glutamatergic excitotoxicity are not completely effective; therefore, research to develop novel compounds is necessary. In this study, the main objective was to determine the pharmacotherapeutic potential of the hydroalcoholic extract of Psidium guajava (PG) in a model of oxidative stress-induced by exposure to glutamate utilizing Danio rerio larvae (zebrafish) as a model. Data showed that treatment with glutamate produced a significant increase in oxidative stress, chromatin damage, apoptosis, and locomotor dysfunction. All these effects were attenuated by pre-treatment with the classical antioxidant N-acetylcysteine (NAC). Treatment with PG inhibited oxidative stress responsible for cellular damage induced by glutamate. However, exposure to PG failed to prevent glutamate-initiated locomotor damage. Our findings suggest that under conditions of oxidative stress, PG can be considered as a promising candidate for treatment of glutamatergic excitotoxicity and consequent neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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282. Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP

Author

Bakshi, Madhura, Wilson, Meredith, Berman, Yemina, Dickson, Rebecca, Fransen, Erik, Helsmoortel, Céline, Van den Ende, Jenneke, Van der Aa, Nathalie, van de Wijdeven, Marina J., Rosenblum, Jessica, Monteiro, Fabíola, Kok, Fernando, Quercia, Nada, Bowdin, Sarah, Dyment, David, Chitayat, David, Alkhunaizi, Ebba, Boonen, Susanne E., Keren, Boris, Jacquette, Aurelia, Faivre, Laurence, Bezieau, Stephane, Isidor, Bertrand, Rieß, Angelika, Moog, Ute, Lynch, Sally Ann, McVeigh, Terri, Elpeleg, Orly, Smeland, Marie Falkenberg, Fannemel, Madeleine, van Haeringen, Arie, Maas, Saskia M., Veenstra-Knol, H.E., Schouten, Meyke, Willemsen, Marjolein H., Marcelis, Carlo L., Ockeloen, Charlotte, van der Burgt, Ineke, Feenstra, Ilse, van der Smagt, Jasper, Jezela-Stanek, Aleksandra, Krajewska-Walasek, Malgorzata, González-Lamuño, Domingo, Anderlid, Britt-Marie, Malmgren, Helena, Nordenskjöld, Magnus, Clement, Emma, Hurst, Jane, Metcalfe, Kay, Mansour, Sahar, Lachlan, Katherine, Clayton-Smith, Jill, Hendon, Laura G., Abdulrahman, Omar A., Morrow, Eric, McMillan, Clare, Gerdts, Jennifer, Peeden, Joseph, Schrier Vergano, Samantha A., Valentino, Caitlin, Chung, Wendy K., Ozmore, Jillian R., Bedrosian-Sermone, Sandra, Dennis, Anna, Treat, Kayla, Hughes, Susan Starling, Safina, Nicole, Le Pichon, Jean-Baptiste, McGuire, Marianne, Infante, Elena, Madan-Khetarpal, Suneeta, Desai, Sonal, Benke, Paul, Krokosky, Alyson, Cristian, Ingrid, Baker, Laura, Gripp, Karen, Stessman, Holly A., Eichenberger, Jacob, Jayakar, Parul, Pizzino, Amy, Manning, Melanie Ann, Slattery, Leah, Van Dijck, Anke, Vulto-van Silfhout, Anneke T., Cappuyns, Elisa, van der Werf, Ilse M., Mancini, Grazia M., Tzschach, Andreas, Bernier, Raphael, Gozes, Illana, Eichler, Evan E., Romano, Corrado, Lindstrand, Anna, Nordgren, Ann, Kvarnung, Malin, Kleefstra, Tjitske, de Vries, Bert B.A., Küry, Sébastien, Rosenfeld, Jill A., Meuwissen, Marije E., Vandeweyer, Geert, and Kooy, R. Frank

Published
2019
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285. Contributors

Author

Augustine, Shancy, primary, Bajpai, Vivek, additional, Barman, Anwesa, additional, Batista, M., additional, Bañon, F., additional, Bhoi, Neeraj Kumar, additional, Brega, Dmytro, additional, Chakradhar, D., additional, Chaudhari, Akshay, additional, Das, Manas, additional, Davim, J. Paulo, additional, Dimitrov, D.M., additional, Gürgen, Selim, additional, Jahan, Muhammad P., additional, Jain, Pramod Kumar, additional, K., Vipindas, additional, Konsulova-Bakalova, M.Iv., additional, Kumar, A. Senthil, additional, Kuriachen, Basil, additional, Lew, Maan Tarng, additional, Littlefair, Guy, additional, Liu, Kui, additional, Mahbub, Md Rashef, additional, Mathew, Jose, additional, Nadda, Rahul, additional, Neo, Dennis Wee Keong, additional, Nirala, Chandrakant K., additional, Patra, Karali, additional, Paul, Lijo, additional, Plankovskyy, Sergiy, additional, Polishetty, Ashwin, additional, Popov, Viktor, additional, Pratap, Tej, additional, Rai, Ravi Shankar, additional, Ranjan, Rachit, additional, Rashid, Asif, additional, Salguero, J., additional, Sambruno, A., additional, Sankaranarayanasamy, Malarvizhi, additional, Sharma, Priyaranjan, additional, Shypul, Olga, additional, Simonet, B., additional, Singh, Harpreet, additional, Slavov, S.D., additional, Sobih, Mohamed, additional, Sofuoğlu, Mehmet Alper, additional, Sol Illana, Irene Del, additional, Tryfonov, Oleg, additional, Tsegelnyk, Yevgen, additional, Ukar Arrien, Eneko, additional, Vazquez-Martinez, Juan Manuel, additional, Wu, Qi, additional, Xu, Weixing, additional, and Zhang, Liangchi, additional

Published
2021
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291. Isospin symmetry in the T = 1,A = 62 triplet

Author

Wimmer, K., primary, Ruotsalainen, P., additional, Lenzi, S.M., additional, Poves, A., additional, Hüyük, T., additional, Browne, F., additional, Doornenbal, P., additional, Koiwai, T., additional, Arici, T., additional, Auranen, K., additional, Bentley, M.A., additional, Cortés, M.L., additional, Delafosse, C., additional, Eronen, T., additional, Ge, Z., additional, Grahn, T., additional, Greenlees, P.T., additional, Illana, A., additional, Imai, N., additional, Joukainen, H., additional, Julin, R., additional, Jungclaus, A., additional, Jutila, H., additional, Kankainen, A., additional, Kitamura, N., additional, Longfellow, B., additional, Louko, J., additional, Lozeva, R., additional, Luoma, M., additional, Mauss, B., additional, Napoli, D.R., additional, Niikura, M., additional, Ojala, J., additional, Pakarinen, J., additional, Pereira-Lopez, X., additional, Rahkila, P., additional, Recchia, F., additional, Sandzelius, M., additional, Sarén, J., additional, Taniuchi, R., additional, Tann, H., additional, Uthayakumaar, S., additional, Uusitalo, J., additional, Vaquero, V., additional, Wadsworth, R., additional, Zimba, G., additional, and Yajzey, R., additional

Published
2023
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292. Decay spectroscopy at the two-proton drip line: Radioactivity of the new nuclides 160Os and 156W

Author

Briscoe, A.D., primary, Page, R.D., additional, Uusitalo, J., additional, Joss, D.T., additional, AlAqeel, M.A.M., additional, Alayed, B., additional, Andel, B., additional, Antalic, S., additional, Auranen, K., additional, Ayatollahzadeh, H., additional, Badran, H., additional, Barber, L., additional, Beeton, G., additional, Birova, M., additional, Bogdanoff, V., additional, Clark, R.M., additional, Cubiss, J.G., additional, Cullen, D.M., additional, Deary, J., additional, Forsberg, U., additional, Grahn, T., additional, Greenlees, P.T., additional, Hilton, J.B., additional, Illana, A., additional, Joukainen, H., additional, Judson, D.S., additional, Julin, R., additional, Jutila, H., additional, Keatings, J.M., additional, Labiche, M., additional, Leino, M., additional, Lewis, M.C., additional, Louko, J., additional, Luoma, M., additional, Martel, I., additional, McCarter, A., additional, McKee, P.P., additional, Mosat, P., additional, Nathaniel, S.N., additional, Neuvonen, O., additional, O'Donnell, D., additional, Ojala, J., additional, Page, C.A.A., additional, Plaza, A.M., additional, Pakarinen, J., additional, Papadakis, P., additional, Parr, E., additional, Partanen, J., additional, Rahkila, P., additional, Ruotsalainen, P., additional, Sandzelius, M., additional, Sarén, J., additional, Saygi, B., additional, Smallcombe, J., additional, Smith, J.F., additional, Sorri, J., additional, Sullivan, C.M., additional, Szwec, S., additional, Tann, H., additional, Tolosa-Delgado, A., additional, Uusikylä, E., additional, Venhart, M., additional, Waring, L.J., additional, and Zimba, G., additional

Published
2023
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294. Precise limits from lepton flavour violating processes on the Littlest Higgs model with T-parity

Author

del Aguila, F., Illana, J. I., and Jenkins, M. D.

Subjects
High Energy Physics - Phenomenology
Abstract

We recalculate the leading one-loop contributions to mu > e gamma and mu -> eee in the Littlest Higgs model with T-parity, recovering previous results for the former. When all the Goldstone interactions are taken into account, the latter is also ultraviolet finite. The present experimental limits on these processes require a somewhat heavy effective scale ~2.5 TeV, or the flavour alignment of the Yukawa couplings of light and heavy leptons at the ~10% level, or the splitting of heavy lepton masses to a similar precision. Present limits on tau decays set no bounds on the corresponding parameters involving the tau lepton, Comment: 41 pages, 11 figures; v3: matches published version in JHEP

Published
2008
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295. Collider aspects of flavour physics at high Q

Author

Lari, T., Pape, L., Porod, W., Aguilar-Saavedra, J. A., del Aguila, F., Allanach, B. C., Alwall, J., Andreev, Yu., Sierra, D. Aristizabal, Bartl, A., Beccaria, M., Bejar, S., Benucci, L., Bityukov, S., Borjanovic, I., Bozzi, G., Burdman, G., Carvalho, J., Castro, N., Clerbaux, B., de Campos, F., de Gouvea, A., Dennis, C., Djouadi, A., Eboli, O. J. P., Ellwanger, U., Fassouliotis, D., Ferreira, P. M., Frederix, R., Fuks, B., Gerard, J. -M., Giammanco, A., Gopalakrishna, S., Goto, T., Grzadkowski, B., Guasch, J., Hahn, T., Heinemeyer, S., Hektor, A., Herquet, M., Herrmann, B., Hidaka, K., Hirsch, M. K., Hohenwarter-Sodek, K., Hollik, W., Hou, G. W. S., Hurth, T., Ibarra, A., Illana, J., Kadastik, M., Kalinin, S., Karafasoulis, C., Unel, M. Karagoz, Kernreiter, T., Kirsanov, M. M., Klasen, M., Kou, E., Kourkoumelis, C., Kraml, S., Krasnikov, N., Krauss, F., Kyriakis, A., Lemaitre, V., Macorini, G., Magro, M. B., Majerotto, W., Maltoni, F., Mehdiyev, R., Misiak, M., Moortgat, F., Moreau, G., Mühlleitner, M., Muntel, M., Onofre, A., Ozcan, E., Palla, F., Panizzi, L., Penaranda, S., Pittau, R., Polesello, G., Pukhov, A., Raidal, M., Raklev, A. R., Rebane, L., Renard, F. M., Restrepo, D., Roupas, Z., Santos, R., Schumann, S., Servant, G., Siegert, F., Skands, P., Slavich, P., Sola, J., Spira, M., Sultansoy, S., Toropin, A., Tricomi, A., Tseng, J., Unel, G., Valle, J. W. F., Veloso, F., Ventura, A., Vermisoglou, G., Verzegnassi, C., del Moral, A. Villanova, Weiglein, G., and Yilmaz, M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

This review presents flavour related issues in the production and decays of heavy states at LHC, both from the experimental side and from the theoretical side. We review top quark physics and discuss flavour aspects of several extensions of the Standard Model, such as supersymmetry, little Higgs model or models with extra dimensions. This includes discovery aspects as well as measurement of several properties of these heavy states. We also present public available computational tools related to this topic., Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 2007

Published
2008
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296. Distinct Impairments Characterizing Different ADNP Mutants Reveal Aberrant Cytoplasmic-Nuclear Crosstalk

Author

Maram Ganaiem, Gidon Karmon, Yanina Ivashko-Pachima, and Illana Gozes

Subjects
activity-dependent neuroprotective protein (ADNP), ADNP syndrome, CRISPR/Cas9, green fluorescent protein (GFP), immunocytochemistry, live cell imaging, Cytology, QH573-671
Abstract

(1) Background: Activity-dependent neuroprotective protein (ADNP) is essential for neuronal structure and function. Multiple de novo pathological mutations in ADNP cause the autistic ADNP syndrome, and they have been further suggested to affect Alzheimer’s disease progression in a somatic form. Here, we asked if different ADNP mutations produce specific neuronal-like phenotypes toward better understanding and personalized medicine. (2) Methods: We employed CRISPR/Cas9 genome editing in N1E-115 neuroblastoma cells to form neuron-like cell lines expressing ADNP mutant proteins conjugated to GFP. These new cell lines were characterized by quantitative morphology, immunocytochemistry and live cell imaging. (3) Results: Our novel cell lines, constitutively expressing GFP-ADNP p.Pro403 (p.Ser404* human orthologue) and GFP-ADNP p.Tyr718* (p.Tyr719* human orthologue), revealed new and distinct phenotypes. Increased neurite numbers (day 1, in culture) and increased neurite lengths upon differentiation (day 7, in culture) were linked with p.Pro403*. In contrast, p.Tyr718* decreased cell numbers (day 1). These discrete phenotypes were associated with an increased expression of both mutant proteins in the cytoplasm. Reduced nuclear/cytoplasmic boundaries were observed in the p.Tyr718* ADNP-mutant line, with this malformation being corrected by the ADNP-derived fragment drug candidate NAP. (4) Conclusions: Distinct impairments characterize different ADNP mutants and reveal aberrant cytoplasmic-nuclear crosstalk.

Published
2022
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297. PERFIL EPIDEMIOLÓGICO DA INTOXICAÇÃO EXÓGENA EM UM ESTADO BRASILEIRO

Author

Ribeiro, Aclênia Maria Nascimento, primary, Cruz, Francisca Maria Pereira da, additional, Pinto, Nayara Vanele Ribeiro, additional, Nascimento, Illana Silva, additional, Pinto, Cyane Fabiele Silva, additional, Mascarenhas, Leonardo Teles Martins, additional, Gonçalves, Pâmela Caroline Guimarães, additional, Fernandes, Marília Silva Medeiros, additional, Amorim, Maria do Socorro Rego de, additional, Rocha, Maria Elizabete de Freitas, additional, Dias, Luzia Fernandes, additional, and Lima, Ana Caroline Escórcio de, additional

Published
2020
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299. CUIDADOS DE ENFERMAGEM NO ATENDIMENTO AO PACIENTE COM TRAUMATISMO CRANIOENCEFÁLICO

Author

Ribeiro, Aclênia Maria Nascimento, primary, Cruz, Francisca Maria Pereira da, additional, Soares, Thayane Silva Vieira Aragão, additional, Pinto, Nielson Valério Ribeiro, additional, Pinto, Cyane Fabiele Silva, additional, Oliveira, Elton Filipe Pinheiro de, additional, Pinto, Dallyane Cristhefane Carvalho, additional, Nascimento, Illana Silva, additional, Santos, Ana Tereza Oliveira, additional, Araújo, Pollyana Rocha de, additional, Cavalcante, Julyana da Costa Lima, additional, and Mascarenhas, Leonardo Teles Martins, additional

Published
2020
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