398 results on '"Haruhiko Kikuchi"'
Search Results
252. Transsphenoidal approach to infrasellar tumors involving the cavernous sinus
- Author
-
Nobuo Hashimoto and Haruhiko Kikuchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Sphenoid Sinus ,Cranial nerve palsy ,Transsphenoidal approach ,Aggressive surgery ,medicine ,Methods ,Humans ,Sella Turcica ,Surgical approach ,Sphenoidal sinus ,Optic canal ,business.industry ,Brain Neoplasms ,Cranial nerves ,Middle Aged ,Magnetic Resonance Imaging ,Cranial Nerve Diseases ,Surgery ,medicine.anatomical_structure ,Cavernous sinus ,Cavernous Sinus ,Female ,business ,Tomography, X-Ray Computed - Abstract
✓ The authors review their 2-year experience with a rhinoseptal transsphenoidal approach to skull-base tumors of various pathologies involving both the sphenoid and cavernous sinuses. Eight patients with cranial nerve palsies attributable to compression of the contents of the cavernous sinus and/or optic canal are included in this report. Among these patients, a total of 17 cranial nerves were affected. Postoperative normalization was achieved in eight nerves, significant improvement in seven nerves, and no improvement in two nerves. There were no operative complications of aggravation of cranial nerve palsies in this series. In spite of the limited operating field, the results demonstrate the effectiveness and safety of this approach. The authors recommend that this approach be considered before more aggressive surgery is undertaken.
- Published
- 1990
253. Intracerebral malignant lymphoma with fluctuating regression and spatial evolution
- Author
-
Haruhiko Kikuchi, Jonathan T. Paine, Yuuta Shibamoto, Junkoh Yamashita, Hirohiko Yamabe, Kouzo Moritake, Nobuko Shima, and Toshiki Yamasaki
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Lymphoma ,medicine.medical_treatment ,Computed tomography ,Malignant lymphoma ,Quality of life ,medicine ,Spatial evolution ,Humans ,Aged ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Middle Aged ,Combined Modality Therapy ,Survival Analysis ,Regression ,Radiation therapy ,Initial lesion ,Surgery ,Female ,Neurology (clinical) ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
Seven patients with histologically proven primary intracerebral malignant lymphoma, characterized by a fluctuating nature with both transient regression and spatial evolution of the tumors without contiguity to the initial lesion, are presented. Although the overall outcome was unfavorable, two cases had a long-term survival of 3 years or more and one of them showed a good quality of life. Correlation among characteristic clinical presentations, computed tomography scans, and prognostic factors after management with surgery, radiation, and chemotherapy, including steroids, is discussed.
- Published
- 1990
254. Origins and distribution of cerebrovascular nerve fibers showing calcitonin gene-related peptide-like immunoreactivity in the major cerebral artery of the dog
- Author
-
Kazuhiko Nozaki, Haruhiko Kikuchi, Yoshihiko Uemura, Noboru Mizuno, and Shinichiro Okamoto
- Subjects
Trigeminal nerve ,General Neuroscience ,Vertebral artery ,Calcitonin Gene-Related Peptide ,Cerebral arteries ,Posterior cerebral artery ,Anatomy ,Biology ,Cerebral Arteries ,Denervation ,Immunohistochemistry ,Ganglionectomy ,Dogs ,Nerve Fibers ,nervous system ,medicine.artery ,Ganglia, Spinal ,medicine ,Basilar artery ,Anterior cerebral artery ,Animals ,Trigeminal Nerve ,Superior cerebellar artery ,Circle of Willis - Abstract
The origins and overall distribution of perivascular nerve fibers showing calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in the major cerebral arteries were investigated immunohistochemically in the dog by using whole-mount preparations of the arterial trees around the circle of Willis. Perivascular nerve fibers with CGRP-LI were seen most abundantly in the basilar artery, vertebral artery, common anterior cerebral artery, proximal part of the anterior cerebral artery, and terminal part of the internal carotid artery. They were far less numerous in the middle cerebral artery, posterior cerebral artery, superior cerebellar artery, and distal part of the anterior cerebral artery. Neuronal cell bodies with CGRP-LI were observed in the trigeminal, nodose, superior cervical, and dorsal root ganglia. CGRP-LI fibers in the large pial arteries in the circle of Willis were eliminated ipsilaterally after unilateral transection of the ophthalmic division of the trigeminal nerve, and slightly reduced in number ipsilaterally after unilateral transection of the maxillary division of the trigeminal nerve. They did not show any noticeable changes after unilateral transection of the mandibular division of the trigeminal nerve. On the other hand, CGRP-LI fibers in the basilar and vertebral arteries did not show any appreciable changes after unilateral transection of the trigeminal nerve, but they were eliminated after bilateral ganglionectomy of the dorsal root ganglia of the first, second, and third cervical nerves. After ganglionectomy of the ciliary, pterygopalatine, otic, nodose, or superior cervical ganglion, no changes were observed in perivascular nerve fibers with CGRP-LI in the major cerebral arteries. The data indicate that perivascular nerve fibers with CGRP-LI in the large pial arteries forming the circle of Willis originate mainly from the ophthalmic division of the trigeminal nerve, and partly from the maxillary division of the trigeminal nerve, and that CGRP-LI fibers in the basilar artery and distal part of the vertebral artery originate mainly from the dorsal root ganglia of the upper cervical nerves.
- Published
- 1990
255. Vascular relaxation properties of calcitonin gene-related peptide and vasoactive intestinal polypeptide in subarachnoid hemorrhage
- Author
-
Yoshihiko Uemura, Haruhiko Kikuchi, Noboru Mizuno, Kazuhiko Nozaki, and Shinichiro Okamoto
- Subjects
Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Calcitonin Gene-Related Peptide ,Vasoactive intestinal peptide ,Calcitonin gene-related peptide ,Cisterna magna ,Dogs ,Internal medicine ,medicine.artery ,Basilar artery ,Medicine ,Animals ,business.industry ,Vasospasm ,Subarachnoid Hemorrhage ,medicine.disease ,Vasodilation ,Disease Models, Animal ,Endocrinology ,Calcitonin ,Basilar Artery ,Arterial blood ,Female ,business ,Vasoactive Intestinal Peptide - Abstract
✓ The vascular relaxation effects of calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) on the dog basilar artery after experimentally produced subarachnoid hemorrhage (SAH) were examined in vitro by an isometric tension recording method. Both CGRP and VIP induced dose-dependent relaxations in ring segments of the intact basilar artery of control dogs. The vasorelaxant action of CGRP was more potent than that of VIP. The single-injection model of SAH was produced by injection of fresh autologous arterial blood ( 1 ml/kg body weight) into the cisterna magna on Day 0 of the post-SAH period, and the double-injection model was produced by two injections of blood (0.5 ml/kg each) on Days 0 and 2. Narrowing of the basilar arteries on vertebral angiograms was most prominent on Day 3 or 7 in the single- or double-injection model, respectively. Relaxation of the basilar artery induced by CGRP and VIP was to some extent decreased on Days 3 and 7 of the post-SAH period in the single-injection model, and on Days 7 and 14 in the double-injection model. However, the vasorelaxant effects of CGRP and VIP were significantly enhanced on Day 14 of the post-SAH period in the single-injection model, and on Days 28 and 42 in the double-injection model. Subsequently, these effects returned to control levels by Days 28 or 63 in the single- or double-injection model, respectively.
- Published
- 1990
256. ChemInform Abstract: A New Synthesis of (-)-Biopterin Employing 5-Deoxy-L-ribose as a Key Intermediate
- Author
-
Haruhiko Kikuchi and Kenji Mori
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,chemistry ,Stereochemistry ,Iodide ,Ribose ,Grignard reaction ,Biopterin ,Stereoselectivity ,General Medicine - Abstract
(-)-Biopterin (1) was synthesized from 5-deoxy-L-ribose (6) which was derived from commercially available D-ribose (2) employing the highly stereoselective Grignard reaction of 2,3-O-cyclohexylidene-D-ribose (3) with methylmagnesium iodide.
- Published
- 1990
257. Cobb's syndrome and its treatment with embolization. Case report
- Author
-
Tomoaki Koide, Haruhiko Kikuchi, S Minami, Shin-ichi Miyatake, Reinin Asato, Izumi Nagata, and Sen Yamagata
- Subjects
medicine.medical_specialty ,Angiomatosis ,Skin Neoplasms ,Adolescent ,medicine.medical_treatment ,Angioma ,Skin nevus ,medicine ,Meningeal Neoplasms ,Nevus ,Humans ,Embolization ,Spinal Neoplasms ,business.industry ,Syndrome ,Thorax ,medicine.disease ,Spinal cord ,Embolization, Therapeutic ,Magnetic Resonance Imaging ,Surgery ,medicine.anatomical_structure ,Cobb syndrome ,Cobb's syndrome ,Female ,Polyvinyls ,business - Abstract
✓ A case of Cobb's syndrome, which is characterized by spinal and vertebral angiomas and a skin nevus at the same metameric level, is reported. The spinal angiomas were treated with liquid embolization using ethylene vinyl alcohol.
- Published
- 1990
258. Efficient tumor suppression by glioma-specific murine cytotoxic T lymphocytes transfected with interferon-gamma gene
- Author
-
Masao Hanaoka, Yoshihiko Watanabe, Haruhiko Kikuchi, Kiyoshi Nishihara, Junkoh Yamashita, Shin-ichi Miyatake, and Yuzirou Namba
- Subjects
Cytotoxicity, Immunologic ,Cancer Research ,Biology ,Transfection ,Interferon-gamma ,Mice ,In vivo ,Glioma ,medicine ,Tumor Cells, Cultured ,Cytotoxic T cell ,Animals ,Effector ,Immunization, Passive ,Cancer ,medicine.disease ,Virology ,Recombinant Proteins ,Mice, Inbred C57BL ,CTL ,IRF1 ,Oncology ,Cancer research ,Immunotherapy ,T-Lymphocytes, Cytotoxic - Abstract
We have recently shown that exogenous expression of the mouse interferon-gamma (IFN-gamma) gene augmented the cell-killing potential of a line of cytotoxic T lymphocytes (CTLs) specific against a murine glioma line (203-glioma). In the present work, we further investigated the in vivo antitumor effects of the E gamma-6 and E gamma-9 sublines of this CTL line transfected with the IFN-gamma gene. Using the Winn assay to test the neutralization of subcutaneous gliomas, we determined that these CTL sublines were more effective than the E-4 parent CTL line and that suppression of the tumor growth was dependent on the number of effector cells (CTLs). Moreover, intravenous injection of E gamma-9 cells was more effective in suppressing the tumor growth than intravenous injection of E-4 cells. These results suggest that transfection of antitumor effector cells with the IFN-gamma gene could improve the efficacy of adoptive immunotherapy against cancer.
- Published
- 1990
259. ChemInform Abstract: Synthesis of (-)-Biopterin
- Author
-
Kenji Mori and Haruhiko Kikuchi
- Subjects
chemistry.chemical_compound ,chemistry ,Stereochemistry ,Block (telecommunications) ,Side chain ,Biopterin ,General Medicine - Abstract
The synthesis of (-)-biopterin (1) was accomplished by employing (1S,2S)-1-(2-furyl)-2-(trityloxy)-1-propanol (6), derived from ethyl (S)-lactate, as building block for the side chain. Synthese von (-)-Biopterin Fur die Synthese von (-)-Biopterin (1) dient das aus (S)-Milchsaure-ethylester gebildete (1S,2S)-1-(2-Furyl)-2-(trityloxy)-1-propanol (6) als Baustein fur die Seitenkette.
- Published
- 1990
260. Evaluation of Glucose Transport in Malignant Glioma by PET
- Author
-
Masatsune Ishikawa, Sadahiko Nishizawa, Haruhiko Kikuchi, and Yoshiharu Yonekura
- Subjects
Human glioma ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Glucose transporter ,medicine.disease ,nervous system diseases ,medicine.anatomical_structure ,Cerebral cortex ,Positron emission tomography ,Glioma ,medicine ,Distribution (pharmacology) ,In patient ,business ,neoplasms - Abstract
Using dynamic PET mode and 18FDG, glucose transport in patients with gliomas were investigated. The values for transfer rate constants kl*, k2*, k3*, and glucose consumption were found to be low in the low-grade glioma as compared to those of the high-grade glioma and the contralateral cerebral cortex. The differences were statistically significant with the exception of k2*. There were no statistically significant differences between the high-grade glioma and the contralateral cerebral cortex. In contrast, the distribution volumes k1*/ k2* and k1*/(k2*+k3*) were low in high-grade glioma and the difference between the high-grade glioma and the contralateral cerebral cortex was statistically significant. A difference in k1*/ (k2*+k3*) was noted between the low-grade and the high-grade gliomas. Thus, the distribution volumes are most sensitive for differentiation between high-grade glioma and cerebral cortex.
- Published
- 1990
261. Cerebral revascularization by omental graft for moyamoya disease
- Author
-
Haruhiko Kikuchi, J. Karasawa, Susumu Miyamoto, and I. Nagata
- Subjects
medicine.medical_specialty ,business.industry ,Cerebral Revascularization ,Posterior cerebral artery ,medicine.disease ,medicine.artery ,Internal medicine ,Middle cerebral artery ,Anterior cerebral artery ,medicine ,Cardiology ,Moyamoya disease ,Internal carotid artery ,business ,Occipital lobe ,Perfusion - Abstract
Several operative procedures have previously been documented for the surgical treatment of cerebrovascular moyamoya disease (1–9). The postoperative improvement in motor or speech impairment can be attributed to improved perfusion in the middle cerebral artery (MCA) distribution following these surgical treatments. However, progressive occlusive lesions are not confined to the MCA in moyamoya disease. They also occur in the internal carotid artery (ICA), the anterior cerebral artery (ACA), and the posterior cerebral artery (PCA) (1,8). Thus cerebral ischaemia in the ACA or PCA distribution results in such symptoms as visual disturbances and motor weakness in the lower extremities in some patients with moyamoya disease. Since most of the current documented operative procedures cannot directly revascularize these regions, omental grafts were performed in 14 cases with ischaemic symptoms in the ACA or PCA areas.
- Published
- 1990
262. Microscopic Visualization of Flow in Rat Cerebral Arteries: Biofluid Dynamical Study on Experimentally Induced Aneurysm
- Author
-
Haruhiko Kikuchi, Hideyuki Niimi, Nobuo Hashimoto, Hideyuki Nakatani, and Saburo Yamaguchi
- Subjects
Pathology ,medicine.medical_specialty ,Chemistry ,Cerebral arteries ,Hemodynamics ,Anatomy ,medicine.disease ,Latex particle ,Apex (geometry) ,Microscopic observation ,Endothelial stem cell ,Aneurysm ,medicine.artery ,cardiovascular system ,medicine ,Anterior cerebral artery ,sense organs ,skin and connective tissue diseases - Abstract
Hemodynamic force may be an important factor to develop cerebral aneurysm since its early change often occurs at the cerebral artery bifurcation [1]. In previous studies [2,3], we proved that a cerebral aneurysm could be induced successfully in rats. The scanning electron microscopic observation on the aneurysm showed early changes of the endothelial cell just distal to the apex of the cerebral artery bifurcation [4]. This suggested that the endothelial change might be closely connected with flow near the apex [3].
- Published
- 1990
263. Commentary
- Author
-
J. Megyesi, J.Max Findlay, Haruhiko Kikuchi, and Kazuhiko Nozaki
- Subjects
Surgery ,Neurology (clinical) - Published
- 1996
264. Ad hoc Reviewers in 1998
- Author
-
Assia Jaillard, LeonardS.W. Li, Haruhiko Kikuchi, L. Poli, Giuseppe Orefice, Dario Grossi, Takenori Yamaguchi, R. T. F. Cheung, Joanna M. Wardlaw, Mario Bo, Akira Ogawa, Blandine Peres, Stanton Newman, Marc Hommel, Molly M. McMahon, Kyeong-Seok Lee, IanJ. Lauder, Eelco F. M. Wijdicks, G.A. Lammie, Michael J. Harrison, Francesca Crawley, Windsor Mak, Mauro Zanocchi, Nina A. Fragassi, Sarah Lunn, Martin M. Brown, KinL. Tsang, Hack-Gun Bae, Il-Gyu Yun, Annalisa Castellano, Jeffery S. Dzieczkowski, GardianC.Y. Fong, Isamu Saito, Roberta Lanzillo, Takashi Yoshimoto, Seemant Chaturvedi, Piero Bottino, KoonH. Chan, Du-Shin Jeong, Piero Secreto, Keiji Sano, Jae-Won Doh, Hajime Yasuhara, and B J Byun
- Subjects
Neurology ,business.industry ,Applied psychology ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 1999
265. Long-term outcome after STA-MCA anastomosis for moyamoya disease
- Author
-
Kazuhiko Nozaki, Haruhiko Kikuchi, Nobuo Hashimoto, Jun Karasawa, Susumu Miyamoto, Izumi Nagata, and Yoshinori Akiyama
- Subjects
medicine.medical_specialty ,business.industry ,Cerebral arteries ,Clinical course ,Cerebral Revascularization ,General Medicine ,Anastomosis ,medicine.disease ,Temporal muscle ,Surgery ,Sta mca anastomosis ,Internal medicine ,medicine ,Cardiology ,Daily living ,Neurology (clinical) ,Moyamoya disease ,business - Abstract
A long-term assessment was performed to determine the posttreatment clinical course of 113 patients with moyamoya disease. All patients sustained cerebral ischemic attacks and underwent superficial temporal artery-middle cerebral artery anastomosis with or without temporal muscle grafting. The follow-up duration was 3 to 24 years (mean 14.4 ± 5.8 [standard deviation]). Complete cessation of the ischemic episodes was obtained in 110 of 113 patients. One hundred patients were able to return to independent acitvities of daily living. Intellectual delays prevented 24 patients from engaging in an independent social life. Although intracranial bleeding is one of the common manifestations in moyamoya disease, hemorrhage was not detected in the 113 patients who underwent cerebral revascularization.
- Published
- 1998
266. Endovascular treatment of posterior circulation aneurysms by detachable coils
- Author
-
Nobuyuki Sakai, Seigo Nagao, Waro Taki, Ichiro Nakahara, Haruhiko Kikuchi, Fumiaki Isaka, and Keiko Irie
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Surgery ,Circulation (currency) ,Neurology (clinical) ,General Medicine ,Endovascular treatment ,business - Published
- 1997
267. Endovascular occlusion of intracranial aneurysms with detachable coils: Correlation between aneurysm neck size and treatment results
- Author
-
Haruhiko Kikuchi, Fumiaki Isaka, Nobuyuki Sakai, Ichiro Nakahara, Seigo Nagao, Keiko Irie, and Waro Taki
- Subjects
medicine.medical_specialty ,business.industry ,Aneurysm neck ,medicine ,Surgery ,Neurology (clinical) ,General Medicine ,Radiology ,Treatment results ,Endovascular occlusion ,business - Published
- 1997
268. Macrophages Activated by Oxidized Membranes of Red Blood Cells Play an Important Role in Cerebral Vasospasm after Subarachnoid Hemorrhage
- Author
-
Xiao-Feng Zhang, Tatsuya Sawamura, Yasushi Iwamuro, Soichi Miwa, Yoshihiko Uemura, Tomoh Masaki, Haruhiko Kikuchi, Ken-ichiro Kikuta, and Taro Komuro
- Subjects
Pharmacology ,Pathology ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Cerebral vasospasm ,Membrane ,business.industry ,medicine ,medicine.disease ,business - Published
- 1997
269. Study for macrophage-induced vascular contraction (model for cerebral vasospasm after subarachnoid hemorrhage)
- Author
-
Tomoh Masaki, Yoshihiko Uemura, Haruhiko Kikuchi, Soichi Miwa, Taro Komuro, Yasushi Iwamuro, Xiao-Feng Zhang, and Tatsuya Sawamura
- Subjects
Pharmacology ,Pathology ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Cerebral vasospasm ,business.industry ,medicine ,Macrophage ,medicine.disease ,business ,Vascular contraction - Published
- 1996
270. PS-28-4 'Cavernous sinus' EEG: a new method for preoperative evaluation of temporal lobe epilepsy
- Author
-
Naoki Oogata, Waro Taki, K. Matsumoto, Akio Ikeda, Nobuhiro Mikuni, Haruhiko Kikuchi, Kenichi Murao, Hiroshi Sibasaki, Ichiro Nakahara, and Kiyohito Terada
- Subjects
medicine.medical_specialty ,Epilepsy ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Cavernous sinus ,medicine ,Neurology (clinical) ,Radiology ,Electroencephalography ,medicine.disease ,business ,Temporal lobe - Published
- 1995
271. PS-28-9 Clinical outcome of surgical resection of the lesion identified by MRI for refractory epilepsy
- Author
-
Haruhiko Kikuchi, Kouzo Moritake, Yoshifumi Matsumoto, and Junko Hatta
- Subjects
Surgical resection ,Lesion ,medicine.medical_specialty ,business.industry ,General Neuroscience ,Refractory epilepsy ,medicine ,Neurology (clinical) ,medicine.symptom ,business ,Outcome (game theory) ,Surgery - Published
- 1995
272. Extended survival with high quality of life in patients with primary intracerebral non-Hodgkin's lymphoma: Report of four cases
- Author
-
Hirohiko Yamabe, Haruhiko Kikuchi, Saburo Nagaoka, Toshiki Yamasaki, Kouzo Moritake, and Nobuko Shima
- Subjects
Vincristine ,medicine.medical_specialty ,Cyclophosphamide ,medicine.medical_treatment ,Malignancy ,Humans ,Medicine ,Chemotherapy ,Brain Neoplasms ,business.industry ,Lymphoma, Non-Hodgkin ,medicine.disease ,Survival Analysis ,Lymphoma ,Non-Hodgkin's lymphoma ,Surgery ,Radiation therapy ,Treatment Outcome ,Quality of Life ,Prednisolone ,Neurology (clinical) ,Radiology ,business ,Follow-Up Studies ,medicine.drug - Abstract
Between 1977 and 1993, we treated 47 patients with histologically verified primary intracerebral non-Hodgkin's lymphoma of B-cell origin. The cases of four of these patients (8.5% of the total) with long-term survival with high quality of life for more than 5 years are presented. Three have remained relapse-free for between 8.5 and 12 years after completion of original treatment; the fourth obtained complete remission for more than 5 years before death from tumor recurrence. All four patients were treated with our institutional therapeutic regimen, which includes radiotherapy consisting of 50–60 Gy to the tumor and 30–40 Gy to the whole brain, followed by four to six cycles of chemotherapy with cyclophosphamide, vincristine, adriamycin, and prednisolone at 4- and 8-week intervals. No further treatment was performed after remission had been obtained. No factors—including patient sex, age, tumor location, multiplicity of lesions, histology, or treatment modality—proved to be specific predictors of therapeutic success. The administration of chemotherapy beginning at the conclusion of radiotherapy in order to enhance the radiation antitumor effect may, however, have contributed to therapeutic success. The finding that all four patients had an immediate response to radiation may be related to their relatively high rate of survival. Histologic examination disclosed small non-cleaved cell lymphoma (high-grade malignancy) in one patient; diffuse large cell lymphoma (intermediate malignancy) in two patients; and small lymphocytic lymphoma (low-grade malignancy) in one patient. Posttherapeutic management during follow-up observation is discussed.
- Published
- 1995
273. Interferon-?? Induces a Decrease in the Susceptibility of Human Glioma Cells to Lysis by Lymphokine-activated Killer Cells
- Author
-
Dali Yin, Seiji Kondo, Juji Takeuchi, Tatsuo Morimura, Shouji Nakatsu, Yoshifumi Oda, and Haruhiko Kikuchi
- Subjects
Surgery ,Neurology (clinical) - Published
- 1994
274. Expression of Fibroblast Growth Factor Receptor-1 in Human Glioma and Meningioma Tissues
- Author
-
Mitsuhiro Ohta, Haruhiko Kikuchi, Yoshifumi Oda, Masakazu Hatanaka, Manabu Fukumoto, Jun A. Takahashi, Nobuyuki Ito, and Tetsuya Ueba
- Subjects
Pathology ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,Oligodendroglioma ,Basic fibroblast growth factor ,Adenocarcinoma ,Astrocytoma ,Filaggrin Proteins ,Biology ,medicine.disease_cause ,Fibroblast growth factor ,Immunoenzyme Techniques ,chemistry.chemical_compound ,Meninges ,Glioma ,Meningeal Neoplasms ,medicine ,Humans ,Receptor, Fibroblast Growth Factor, Type 1 ,neoplasms ,Neurons ,Brain Neoplasms ,Fibroblast growth factor receptor 1 ,Growth factor ,Brain ,Receptor Protein-Tyrosine Kinases ,medicine.disease ,Receptors, Fibroblast Growth Factor ,nervous system diseases ,Gene Expression Regulation, Neoplastic ,Cytokine ,chemistry ,Immunohistochemistry ,Surgery ,Endothelium, Vascular ,Neurology (clinical) ,Glioblastoma ,Meningioma ,Carcinogenesis ,Cell Division - Abstract
We examined the expression of fibroblast growth factor receptor-1 (FGFR-1), namely FLG, in tissues of 18 human gliomas, 10 human meningiomas, 3 human metastatic brain tumors, and 2 normal human brains by means of immunohistochemistry. All tissues were positively stained for FGFR-1. Primary brain tumors were more abundantly immunoreactive than normal brain tissues (Mann-Whitney U test, P < 0.05). There was significant correlation between the expression level of basic fibroblast growth factor (basic FGF) and that of FGFR-1 in tissues of human glioma (Spearman's test, P < 0.05). The expression level of FGFR-1 of tumor cells increased in correlation with that of endothelial cells in glioma tissues (Spearman's test, P < 0.001). We previously reported that basic FGF is produced in more than 90% of human glioma and meningioma tissues. Together with these data, it is suggested that basic FGF is involved in autonomous cell growth and tumorigenesis of gliomas and meningiomas as an autocrine growth factor in vivo.
- Published
- 1994
275. Selective neuronal vulnerability to transient forebrain ischemia: An in situ labeling study of double-strand DNA breaks in the gerbil
- Author
-
Yoshihiko Uemura, Haruhiko Kikuchi, Masahiko Takada, Noboru Mizuno, and Shobu Namura
- Subjects
Double-Strand DNA Breaks ,General Medicine ,Degeneration (medical) ,Biology ,Gerbil ,Forebrain ischemia ,Neuroscience ,Neuronal vulnerability - Published
- 1994
276. Analysis of expression and secretion of PDGF-B chain of cultured aortic endothelial cell of stroke-prone SHR
- Author
-
Masakiyo Sasahara, Yukikazu Saeki, Fumitada Hazama, Haruhiko Kikuchi, Koji Iihara, and Nobuo Hashimoto
- Subjects
PDGF B-chain ,medicine.medical_specialty ,Endocrinology ,business.industry ,Internal medicine ,Medicine ,Secretion ,Aortic endothelial cell ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Stroke - Published
- 1993
277. Therapeutic Trial of Cerebral Vasospasm with the Serine Protease Inhibitor, FUT-175, Administered in the Acute Stage after Subarachnoid Hemorrhage
- Author
-
Haruhiko Kikuchi, Yukio Shimizu, Shinichiro Okamoto, Manabu Sato, Shyunichi Yoneda, and Hiroji Yanamoto
- Subjects
Adult ,Male ,Serine Proteinase Inhibitors ,Subarachnoid hemorrhage ,Guanidines ,Severity of Illness Index ,Group A ,Cerebral vasospasm ,Humans ,Medicine ,cardiovascular diseases ,Aged ,Serine protease ,Hematoma ,biology ,business.industry ,Cerebral infarction ,Incidence (epidemiology) ,Anti-Inflammatory Agents, Non-Steroidal ,Therapeutic effect ,Intracranial Aneurysm ,Vasospasm ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,Benzamidines ,Cerebral Angiography ,Treatment Outcome ,Ischemic Attack, Transient ,Anesthesia ,Acute Disease ,biology.protein ,Female ,Surgery ,Neurology (clinical) ,business - Abstract
The therapeutic effect of the synthetic serine protease inhibitor, FUT-175, on cerebral vasospasm after subarachnoid hemorrhage (SAH) was investigated. Twenty-three patients with severe SAH who were admitted between February and July 1990 and who underwent surgery within 48 hours of the initial aneurysmal rupture were treated with an intravenous administration of FUT-175 soon after the operation. The patients were divided randomly into three groups, each receiving a different dose of FUT-175 (Group A, 20 mg every 12 hours for 4 days; Group B, 20 mg every 6 hours for 4 days, Group C, 40 mg every 6 hours for 4 days). The results were compared with another group of twenty-two patients with severe SAH who were admitted before February 1990 and received equivalent treatment, except they were not treated with FUT-175. In 64% of all the patients treated with FUT-175 (Groups A, B, C), and in 85% of those treated with higher doses of FUT-175 (Groups B and C), there was no spasm or only mild vasospasm on the angiogram. The incidence of a delayed ischemic neurological deficit significantly decreased from 55% in the control group to 13% in all patients treated with FUT-175 and to 7% in the patients treated with higher doses (P less than 0.05). The incidence of cerebral infarction resulting from vasospasm significantly decreased from 43% in the control group to 9% in patients treated with FUT-175. In the patients treated with higher doses of FUT-175 (Groups B and C), none developed cerebral infarction.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
278. [Untitled]
- Author
-
Haruhiko Kikuchi
- Subjects
Surgery ,Neurology (clinical) - Published
- 1992
279. Effects of transient global ischemia on dopaminergic neuronal functions in rat striatum
- Author
-
Kunio Koshimura, Yoshinori Akiyama, Soichi Miwa, Haruhiko Kikuchi, and Sen Yamagata
- Subjects
Pharmacology ,Rat striatum ,Chemistry ,Dopaminergic ,Ischemia ,medicine ,Transient (computer programming) ,medicine.disease ,Neuroscience - Published
- 1991
280. Pharmacological studies of N-3256, a novel 5-HT3 receptor antagonisto
- Author
-
Toshio Suguro, Toru Hayakawa, Haruhiko Kikuchi, Koichiro Hagihara, and Setsuko Mino
- Subjects
Pharmacology ,biology ,Chemistry ,biology.protein ,5-HT3 receptor - Published
- 1991
281. The mechanisms of decreased responsiveness of dopaminergic neurons to high K+ stimulation after transient global ischemia
- Author
-
Yoshinori Akiyama, Haruhiko Kikuchi, Sen Yamagata, Soichi Miwa, and Kunio Koshimura
- Subjects
Pharmacology ,medicine.medical_specialty ,Chemistry ,Potassium ,Dopaminergic ,Ischemia ,chemistry.chemical_element ,Stimulation ,medicine.disease ,Endocrinology ,Internal medicine ,medicine ,Transient (oscillation) ,Decreased responsiveness - Published
- 1991
282. Angiographic study of induced cerebral aneurysms in primates
- Author
-
Haruhiko Kikuchi, Choegon Kim, Fumitada Hazama, and Nobuo Hashimoto
- Subjects
medicine.medical_specialty ,Fusiform Aneurysm ,Autopsy ,Renal Artery ,Aneurysm ,otorhinolaryngologic diseases ,Berry Aneurysm ,medicine ,Animals ,cardiovascular diseases ,Thrombus ,Ligation ,medicine.diagnostic_test ,business.industry ,Intracranial Aneurysm ,Cerebral Arteries ,respiratory system ,medicine.disease ,Cerebral Angiography ,Macaca fascicularis ,Carotid Arteries ,Connective Tissue ,Aminopropionitrile ,Angiography ,cardiovascular system ,Female ,Surgery ,Neurology (clinical) ,Radiology ,business ,Cerebral angiography - Abstract
Five cynomolgus monkeys treated with unilateral carotid ligation, renal hypertension, and β-aminopropionitrile feeding were studied repeatedly by cerebral angiography to clarify the growth process of saccular cerebral aneurysms. Repeated angiography demonstrated saccular cerebral aneurysms in three of five monkeys; two aneurysms were found 15 months and a third 12 months after the operation. At autopsy, one saccular aneurysm was found to be bilocular in shape, and the others were unilocular. Fusiform aneurysms were also observed in four monkeys. Microscopic studies revealed the walls of the saccular aneurysms were very thin and consisted of fibrous tissue. In one aneurysm, the aneurysmal sac was almost obstructed by a well-organized thrombus. No evidence of intramural hemorrhage was found in any of the saccular cerebral aneurysms. The conversion of early aneurysmal changes into saccular aneurysms was found in any of the abruptly, and no consistent growth rate was noted. The multiloculation of saccular aneurysms was closely related to the size of an aneurysm. The present study indicates that a saccular cerebral aneurysm may grow abruptly from one of several different kinds of early aneurysmal changes.
- Published
- 1990
283. Treatment of a giant aneurysm of the cavernous internal carotid artery associated with a persistent primitive trigeminal artery
- Author
-
Sen Yamagata, Soh-ichirou Kondoh, Izumi Nagata, Haruhiko Kikuchi, Shin-ichi Miyatake, and Toshio Higashi
- Subjects
medicine.medical_specialty ,Balloon ,Surgical anastomosis ,Aneurysm ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,business.industry ,Intracranial Aneurysm ,Cerebral Arteries ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Thrombosis ,Surgery ,medicine.anatomical_structure ,Bypass surgery ,cardiovascular system ,Trigeminal artery ,Female ,Neurology (clinical) ,Radiology ,Internal carotid artery ,Tomography, X-Ray Computed ,business ,Ligation ,Carotid Artery, Internal - Abstract
A case of an unruptured giant aneurysm of the cavernous portion of the left internal carotid artery associated with a persistent primitive trigeminal artery (PTA) is presented. The usual surgical approach to giant aneurysms at this site. including ligation of the ipsilateral internal carotid artery (ICA) and an extracranial-intracranial (EC-IC) bypass, was inadequate because of continued blood supply to the aneurysm via the PTA from the vertebrobasilar system. The patient was successfully treated with a combination of EC-IC bypass surgery, ICA ligation, and simultaneous intravascular balloon obliteration of the ICA just distal to the junction of the PTA and immediately proximal to the aneurysmal neck. Follow-up radiological investigations showed thrombosis of the aneurysm.
- Published
- 1990
284. Monitoring System of Local Cortical Blood Flow during Operation
- Author
-
Ikuo Ihara, Tetsuo Yamashita, Haruhiko Kikuchi, Izumi Nagata, Takashi Ueda, Shigekazu Takeuchi, and Jun Karasawa
- Subjects
Adult ,Male ,Hot Temperature ,Adolescent ,Arterial Occlusive Diseases ,Anastomosis ,Hypocapnia ,medicine.artery ,medicine ,Humans ,Moyamoya disease ,Child ,Aged ,Monitoring, Physiologic ,Cerebral Cortex ,Cerebral Revascularization ,business.industry ,Blood flow ,Carbon Dioxide ,medicine.disease ,Electroplating ,Stenosis ,Bypass surgery ,Regional Blood Flow ,Cerebrovascular Circulation ,Child, Preschool ,Anesthesia ,Middle cerebral artery ,Female ,Surgery ,Neurology (clinical) ,Moyamoya Disease ,Internal carotid artery ,business ,Hydrogen - Abstract
Local cortical blood flow (LCBF) was measured during extracranial-intracranial (EC-IC) bypass surgery in 14 hemispheres of 12 patients with moyamoya disease, 8 hemispheres of 8 patients with occlusion or stenosis of the internal carotid or middle cerebral artery, and 2 hemispheres of 2 patients with an unruptured internal carotid aneurysm. Measurement of LCBF was performed with the clearance method of hydrogen gas generated by electrolysis (H2-method) and the heat clearance method (heat-method), using the plate type probe in both methods. LCBF measured by the H2-method was distinctly lower in all the patients with occlusive lesions before the EC-IC bypass, than in one patient without occlusive lesions. LCBF after bypass was increased in the territory of the recipient artery of all the patients with occlusive lesions, including moyamoya disease, except for one patient with stenosis of the middle cerebral artery. LCBF was not always increased after bypass in the area apart from the recipient artery, or the area on the opposite side of the Sylvian fissure of the patients with moyamoya disease. The LCBF measured by the heatmethod was hardly decreased by the clamping of the recipient artery in the part near the recipient artery before the bypass. The LCBF measured by the heat-method was promptly decreased by the clamping of the donor artery and increased by the release of the clamp after bypass. According to this evidence, the patency of the anastomosis and the surface area fed by the donor artery were confirmed after bypass. CO2 reactivity was studied by the heat-method in patients with moyamoya disease. In many of them, LCBF was not increased during hypercapnia but was decreased during hypocapnia. In the patients with unruptured internal carotid aneurysm, the heat-method was useful for determining the influence of clamping of the internal carotid artery on the LCBF before permanent ligation of the internal carotid artery. The H2-method is quantitative but interrupted, whereas the heat-method is continuous qualitative. It is quite possible that simultaneous LCBF measurements by both methods during bypass surgery are useful not only for the study of the cerebral hemodynamics but also for the monitoring system during operation.
- Published
- 1984
285. Cerebral circulation and metabolism in adults' Moyamoya disease-PET study
- Author
-
Hidenao Fukuyama, Haruhiko Kikuchi, Yoshiharu Yonekura, Yasuhiro Yonekawa, Sadahiko Nishizawa, Akira Kobayashi, Waro Taki, Masatsune Ishikawa, and S. Tanada
- Subjects
Adult ,Male ,medicine.medical_specialty ,Neurology ,Hemodynamics ,Arterial Occlusive Diseases ,Blood volume ,White matter ,Cerebral circulation ,Oxygen Consumption ,Internal medicine ,Humans ,Medicine ,Moyamoya disease ,medicine.diagnostic_test ,business.industry ,Brain ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Cerebral blood flow ,Positron emission tomography ,Cerebrovascular Circulation ,Anesthesia ,Cardiology ,Female ,Surgery ,Neurology (clinical) ,Moyamoya Disease ,business ,Tomography, Emission-Computed - Abstract
Regional cerebral blood flow (rCBF), oxygen extraction fraction (rOEF), cerebral metabolic rate for oxygen (rCMRO2) and cerebral blood volume (rCBV) in nine cases of moyamoya disease in adults were studied with positron emission CT (PET) scan, using 15O steady-state methods. Three cases showed ischaemic symptoms and the other six cases showed haemorrhagic symptoms. PET scan was performed during the chronic stage. Control data were obtained from eight normal volunteers. Regional cerebral blood flow and other physiological parameters in cerebral gray matter, white matter and basal ganglia were compared with normal controls. All nine cases of Moyamoya disease showed decreased rCBF, though not significant, in cerebral gray matter, white matter and basal ganglia. Reduction of rCBF was significant in the cerebral cortex of six haemorrhagic cases. This significant decrease was considered to be due to diaschisis and also brain atrophy caused by the cerebral haemorrhage. There was a significant increase in rCBV in white matter of the both ischaemic and haemorrhagic cases. The calculated value of CBF/CBV is considered to be an index of perfusion pressure. This value was significantly decreased in all three regions, though rOEF was not significantly increased in moyamoya disease. Hence the cerebral circulation in adults with moyamoya disease appears to be characterized by a mild decrease in perfusion pressure and prolonged circulated time.
- Published
- 1989
286. Intraoperative Sonography in the Surgical Treatment of Epilepsy
- Author
-
M Takaya, Kouzo Moritake, Jun Minamikawa, Kunio Yamamura, and Haruhiko Kikuchi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Medically intractable epilepsy ,Intraoperative ultrasonography ,Magnetic resonance imaging ,medicine.disease ,Epilepsy ,medicine ,Choroid plexus ,Cerebellar tentorium ,Radiology ,Ultrasonography ,business ,Surgical treatment - Abstract
Ultrasonography was attempted to be utilized intraoperatively in 14 patients with medically intractable epilepsy. In nine of these 14 patients, epileptogenic foci were identified directly by intraoperative ultrasonogra-phy. All of the lesions with cystic components were clearly demonstrated. However, intraoperative ultrasonography could not depict satisfactorily all of the calcified lesions which had been demonstrated distinctly on preoperative CT and MRI. Even if ultrasonography could not demonstrate epileptogenic lesions, it was useful for determining localization of the lesions intraoperatively by three dimensional measurements of their location and extent by referring to sonographically identifiable structures, such as the ventricles, choroid plexus, falx, cerebellar tentorium and so on. Ultrasonography is considered to be useful as an intraoperative complement of structural studies in the surgical treatment of epilepsy.
- Published
- 1989
287. Cerebral Blood Flow as a Prognostic Indication in Subarachnoid Hemorrhage
- Author
-
Masato Matsumoto, Y Naruo, Sen Yamagata, Naohiro Yamazoe, Haruhiko Kikuchi, Izumi Nagata, Takayuki Koizumi, Yoshinori Akiyama, Kenji Hashimoto, Kameyoshi Mitsuno, Ikuo Ihara, Jun Minamikawa, Susumu Miyamoto, and Yoshito Morooka
- Subjects
Male ,Time Factors ,Subarachnoid hemorrhage ,Cerebral vasospasm ,medicine ,Humans ,Subdural space ,Depression (differential diagnoses) ,Aged ,Monitoring, Physiologic ,Intracranial pressure ,business.industry ,Vasospasm ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,Intracerebral hematoma ,medicine.anatomical_structure ,nervous system ,Cerebral blood flow ,Ischemic Attack, Transient ,Cerebrovascular Circulation ,Anesthesia ,cardiovascular system ,Female ,Surgery ,Neurology (clinical) ,business ,circulatory and respiratory physiology - Abstract
In an investigation of the changes in cerebral blood flow (CBF) in subarachnoid hemorrhage, CBF was monitored in 14 patients who underwent surgery within 3 days of the onset of hemorrhage. On admission, one patient was neurological grade I, one was grade II, seven were grade III, and five were grade IV. Computed tomography showed diffuse, thick subarachnoid hemorrhage with or without intracerebral hematoma in all patients, strongly indicating the possibility of cerebral vasospasm. CBF monitoring was performed by the thermal diffusion technique, in which a small flow probe, 7 mm in diameter and 4 mm in height and containing a Peltier stack, is used. The probe was implanted in the subdural space in the frontotemporal region during surgery. Epidural intracranial pressure was also monitored. Local CBF was measured continuously for 7 to 19 days after surgery. Immediately after surgery, CBF was low in grade IV patients (mean, 25 ml/100 g/min), whereas a variety of CBF rates were observed in grade III patients. Minimal decreases in CBF were noted in the grades I and II patients (mean, 41 ml/100 g/min). The sequential changes in CBF were well correlated with outcome. The two grades I and II patients, who had no appreciable decrease in CBF, had excellent outcomes. In the five (of seven) grade III patients who showed good or excellent recovery, CBF was maintained with only a slight decrease. In two grade III patients, substantial depression of CBF occurred several days after the onset of subarachnoid hemorrhage; one had a poor outcome, and one died. Good recovery of CBF was observed in one grade IV patient, who showed excellent postoperative recovery. The remaining four patients, had moderate to substantial decreases in CBF, with poor postoperative results, including two deaths. These observations indicate that a decrease in CBF due to vasospasm or other causes can be detected early through CBF monitoring. In addition, the outcome of subarachnoid hemorrhage can be predicted on the basis of sequential changes in CBF.
- Published
- 1988
288. [Untitled]
- Author
-
Mitsuru Ueda, Nobuo Moriyasu, Tadashi Maekawa, Shigeo Kariyone, Hiroshi Higuchi, Hidenori Maezawa, Sukeo Yamamoto, Shunichi Saso, Nobumasa Kuwana, Mitsunori Morimatsu, Mutsuyoshi Kazama, Masaharu Yoshimura, Yoshio Iwasaki, Akira Takahashi, Sumitaka Tokito, Yuzuru Sugawara, Masao Kase, Suguru Takagi, Mitsuru Okubo, Iwao Naito, Takeshi Abe, Teruhiko Tanaka, Haruhiko Kikuchi, Tsutomu Odakura, Shozo Kito, Hamao Ijichi, and Kenji Takasu
- Subjects
Urokinase ,medicine.medical_specialty ,business.industry ,General Medicine ,Placebo ,Surgery ,Double blind study ,Cerebral thrombosis ,Anesthesia ,Statistical significance ,medicine ,Liver function ,business ,Liver functions ,Clinical evaluation ,medicine.drug - Abstract
A multi-center double blind study for the clinical evaluation of TCUK was carried out on 115 patients with cerebral thrombosis.The administration of TCUK was done continuously in doses of 60, 000 I. U. for 7 days under comparison with negative placebo.The study was performed according to the protocol, shown in Table 1-6 and the effects of TCUK were judged by the grade of improvement of apparent subjective complaints, disturbances of consciousness, motorius and sensorial disorders of extremities and comprehensive daily life activities. The total scoring of improvements in individual disorders and their comprehensive evaluation were made for judgement of the global improvement and availability of the drugs, obtaining the following conclusions:(1) The availability, particularly the global improvement of TCUK were better than those of placebo in their statistical significance (Table 10).(2) In the serial evaluations, the clinical effects were more significant in patient groups of mild or moderate grades in the severity of disorders, of ages between 40-69, without histories of brain damages and without simultaneous infusions of large amount of solutions.(3) The side effects of TCUK were rare (Table 11) with only two exceptional cases with disturbance of liver functions (Table 18), but the relationship between this liver function disturbance and administration of TCUK was obscure and no cases of hemorrhagic infarction were found in connection with TCUK administration in this study.
- Published
- 1981
289. Specific cytotoxic activity of T lymphocyte clones derived from a patient with gliosarcoma
- Author
-
Yuziro Namba, Haruhiko Kikuchi, Li Zy, Junkoh Yamashita, Shin-ichi Miyatake, Masao Hanaoka, and Kouichi Iwasaki
- Subjects
Male ,Interleukin 2 ,CD4 antigen ,Lymphocyte ,CD3 ,Biology ,chemistry.chemical_compound ,Antigen ,medicine ,Humans ,Cytotoxic T cell ,Antigens ,Brain Neoplasms ,Cell Membrane ,Glioma ,T lymphocyte ,Middle Aged ,Cytotoxicity Tests, Immunologic ,Molecular biology ,Autologous tumor cell ,Clone Cells ,Phenotype ,medicine.anatomical_structure ,chemistry ,Immunology ,biology.protein ,T-Lymphocytes, Cytotoxic ,medicine.drug - Abstract
✓ Eleven lymphocyte clones were established from the peripheral blood lymphocytes of a patient with gliosarcoma by means of autologous tumor stimulation and the limiting-dilution technique with recombinant interleukin-2. Ten of the 11 clones were cytotoxic against the autologous tumor cell line GI-1. Seven of the 10 clones were also cytotoxic against allogeneic brain-tumor lines and HeLa cells, one clone was cytotoxic against several target cells, and two clones were specifically cytotoxic against GI-1 and allogeneic brain-tumor cells. One of the 11 clones was not cytotoxic against any target cells tested. Lymphokine-activated killer cells induced by recombinant interleukin-2 alone exhibited cytotoxic activity against all target tumor cells tested. Surface phenotypic analysis revealed that all lymphocyte clones expressed CD3 antigen, some expressed CD4 antigen, and others expressed CD8 antigen. These clones seemed to be antigen-specific cytotoxic T lymphocyte clones. Analysis with these antigen-specific cytotoxic T lymphocyte clones may be useful in the elucidation of tumor-specific or tumor-associated antigens on autologous tumor cells.
- Published
- 1988
290. Operative Indication and Surgical Technique of the Cerebral Aneurysm 2
- Author
-
Haruhiko Kikuchi
- Subjects
medicine.medical_specialty ,Aneurysm ,Text mining ,business.industry ,General surgery ,medicine ,Surgery ,Neurology (clinical) ,medicine.disease ,business - Published
- 1976
291. Measurement of Human Spinal Cord Blood Flow using Xenon and Computerized Tomography
- Author
-
Haruhiko Kikuchi, Jun Karasawa, Yoshihiro Kuriyama, and Toshio Ikota
- Subjects
Adult ,Xenon ,business.industry ,Middle Aged ,Spinal cord blood flow ,Co2 reactivity ,Clinical study ,Spinal Cord ,Anesthesia ,Humans ,Medicine ,Surgery ,Neurology (clinical) ,Tomography ,Child ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Aged ,Spinal cord pathology - Abstract
Noninvasive measurement of human spinal cord blood flow (SCBF) has not yet been established. The authors successfully measured human SCBF by using xenon and a CT scanner (Shuttle method). This method was clinically applied in 10 patients without spinal cord pathology. Mean SCBF of the normal adult at the C5 level was 42.3 ± 6.3 ml/ 100 g/min. CO2 reactivity in SCBF was also detected. This method may well be used in the clinical study of human SCBF.
- Published
- 1983
292. The effects of arterial carbon dioxide tension on cerebral blood flow and on cerebral function in 'moyamoya' disease
- Author
-
Fukuichiro Okumura, Shigekazu Takeuchi, Izumi Nagata, Haruhiko Kikuchi, Shiro Oku, and Jun Karasawa
- Subjects
Cerebral blood flow ,business.industry ,Anesthesia ,Cerebral function ,Medicine ,Arterial carbon dioxide tension ,Moyamoya disease ,business ,medicine.disease - Abstract
小児もやもや病患者12名についてジアゼパムーフェンタニル麻酔下にPaCO2を変化させて全脳および大脳皮質の脳血流量の変化を測定し, 同時に Anesthesia and Brain activity Monitor によるEEGを記録した. PaCO2 53mmHgの hypercapnia 時脳血流量は全脳では平均32%, 大脳皮質では平均12%の有意でない増加傾向を示したが, 減少する例も見られた. 平均PaCO2 33mmHgの hypocapnia 時は全脳では平均28%, 大脳皮質では平均20%の有意な減少を示した. 脳血流量の変化とEEG平均周波数および平均振幅の変化との間に一定の傾向はみられなかった. 小児もやもや病の麻酔管理に際しては hypocapnia をさけるのは当然であるが hypercapnia よりも normocapnia が好ましい.
- Published
- 1985
293. Pathological Study of Late Arterial Spasm
- Author
-
Kyoi K, Haruhiko Kikuchi, Toshisuke Sakaki, Tatsuo Tanigake, Yoshio Hiasa, Yoshio Murata, and Shozaburo Utumi
- Subjects
Tunica media ,Subarachnoid hemorrhage ,business.industry ,Brain damage ,Anatomy ,medicine.disease ,Internal elastic lamina ,medicine.anatomical_structure ,Cerebral vasospasm ,Aneurysm ,Atrophy ,Edema ,medicine ,Surgery ,Neurology (clinical) ,medicine.symptom ,business - Abstract
It is well known that cerebral vasospasm following ruptured cerebral aneurysm affects the prognosis very seriously after direct surgery. However, the pathogenesis of cerebral vasospasm remains obscure. Furthermore, the precise brain damage following it has not been made clear histopathologically. The histopathological postmortem studies of intracranial arteries with angiographycally demonstrated arterial narrowing have been carried out in 44 cases. The cerebral arterial wall corresponding to the angiographic vasospasm showed various structural changes, which could be divided into five groups according to histological findings. In Group 1, the intraluminal size of arterial wall was reduced even though the medial thickening, marked corrugation of the internal elastic lamina and intimal edema were demonstrated. In Group 2, necrosis of smooth muscle cells in the tunica media, partial break of internal elastic lamina and the profuse deposition of acid mucopolysaccharides were seen. In Group 3, marked intimal thickening and the medial atrophy were seen. In Group 4, dilatation of luminal size with improvement of the intimal thickening and the remarkable medial atrophy were noted. In Group 5, regeneration of smooth muscle cell in the tunica media was observed. These histological findings suggest the time course of cerebral arterial spasm from onset to remission.
- Published
- 1979
294. Cerebral circulation and oxygen metabolism in Moyamoya disease of ischemic type in children
- Author
-
Sadahiko Nishizawa, Haruhiko Kikuchi, Kiyoshi Harada, Shuji Tanada, Yoshiharu Yonekawa, Akira Kobayashi, Yasuhiro Yonekawa, Waro Taki, Michio Senda, Matsatsune Ishikawa, and Hidenao Fukuyama
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Ischemia ,Arterial Occlusive Diseases ,Brain Ischemia ,White matter ,Cerebral circulation ,Oxygen Consumption ,Oxygen Radioisotopes ,Internal medicine ,medicine ,Humans ,Moyamoya disease ,Child ,Stroke ,Blood Volume ,business.industry ,Brain ,General Medicine ,Blood flow ,medicine.disease ,medicine.anatomical_structure ,Cerebral blood flow ,Cerebrovascular Circulation ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Cardiology ,Female ,Neurology (clinical) ,Moyamoya Disease ,business ,Perfusion ,Tomography, Emission-Computed - Abstract
Cerebral rCBF, rOEF, rCMRO2, and rCBV in moyamoya disease were studied by means of positron emmission tomography (PET), using 15O as a tracer. Steady-state methods with C15O2 and 15O2 were used to obtain the functional images of rCBF, rCMRO2, and rOEF. The 15O single-inhalation method was used to obtain the rCBV image. Five children (two boys and three girls) with mean age of 11 years and eight normal volunteers with mean age of 31 years were included in the study. The symptoms of moyamoya disease were due to cerebral ischemia, such as transient ischemic attack (TIA), reversible ischemic neurological deficit (RIND), and minor stroke. The interval between the latest ictus and PET scan ranged from 3 days to 3 years 6 months. Physiological parameters (rCBF, rCMRO2 etc.) in cerebral gray matter, cerebral white matter and basal ganglia were calculated from the single functional images. Any, low density areas appearing in X-ray-CT performed just prior to the PET study were carefully excluded from the analysis. The parameters of moyamoya disease were statistically compared with normal control parameters. Though the value of rCBF was slightly higher in moyamoya disease, this difference was not statistically significant. On the other hand, in moyamoya disease rCBV increased significantly in gray matter, white matter, and basal ganglia. The ratio of CBF to CBV is considered to be the index of perfusion pressure and reciprocal of cerebral mean transit time under the normal autoregulation of CBF. This ratio was calculated and compared with the normal value for each tissue. The ratio was significantly decreased in each tissue in moyamoya disease, indicating the presence of a low perfusion pressure in the moyamoya brain. In general, when the reduction of perfusion pressure becomes profound the decrease in the CBF-to-CBV ratio is followed by an increase in rOEF. In spite of the reduction in the CBF-to-CBV ratio there was no significant increase in rOEF in moyamoya disease. Thus, the cerebral circulation in childhood moyamoya disease of ischemic type was characterized by a mild decrease in perfusion pressure and a prolonged circulation time.
- Published
- 1988
295. Reflectance Spectrophotometric Measurement of in vivo Local Oxygen Consumption in the Cerebral Cortex
- Author
-
Haruhiko Kikuchi, Kinuta Y, Masatsune Ishikawa, Osamu Hirai, Shuichi Kobayashi, and Kiyoharu Imataka
- Subjects
Pentobarbital ,chemistry.chemical_element ,Brain damage ,Oxygen ,Hemoglobins ,Oxygen Consumption ,Gyrus ,Pressure ,medicine ,Animals ,Oxygen saturation (medicine) ,Cerebral Cortex ,Chemistry ,Blood flow ,medicine.anatomical_structure ,Neurology ,Spectrophotometry ,Cerebral cortex ,Anesthesia ,Cats ,Neurology (clinical) ,Hemoglobin ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.drug ,Biomedical engineering - Abstract
A simple method was developed to measure in vivo local oxygen consumption quantitatively in the brain cortex. Reflectance spectra of tissue hemoglobin at the brain's surface were measured for assessment of both local tissue hemoglobin content and its oxygen saturation. Local oxygen consumption was calculated from the spectral changes of tissue hemoglobin during complete cessation of blood flow by compression of the cortical surface in the suprasylvian gyrus with the tip of an optic probe. This procedure was performed without any brain damage and only took ∼5 s. The calculated local oxygen consumption during this short period of compression remained constant for a few seconds. Then, it decreased rapidly, although the local tissue hemoglobin was not completely deoxygenated. The value of local cerebral oxygen consumption obtained by this method was 3.02 ± 0.61 mL O2/100 g brain/min; it was not influenced by the change in systemic blood pressure. The effect of pentobarbital on cerebral oxygen consumption was also studied. At the stage of burst and suppression on electrocorticogram, cerebral oxygen consumption decreased significantly (p < 0.001) to 1.03 ± 0.07 mL O2/100 g brain/min.
- Published
- 1987
296. Tonsillar Herniation on Magnetic Resonance Imaging
- Author
-
Yasuhiro Yonekawa, Masatsune Ishikawa, Haruhiko Kikuchi, and Ichiro Fujisawa
- Subjects
Adult ,Male ,medicine.medical_specialty ,Hernia ,Adolescent ,Medullary cavity ,Palatine Tonsil ,Cerebrospinal fluid ,stomatognathic system ,Reference Values ,otorhinolaryngologic diseases ,Humans ,Medicine ,Child ,Papilledema ,Aged ,Intracranial pressure ,Chiari malformation ,Foramen magnum ,Brain Neoplasms ,business.industry ,Infant ,Pharyngeal Diseases ,Middle Aged ,respiratory system ,medicine.disease ,Magnetic Resonance Imaging ,Arnold-Chiari Malformation ,medicine.anatomical_structure ,Cranial Fossa, Posterior ,Child, Preschool ,Tonsil ,Cerebellar tonsil ,Female ,Surgery ,Radiology ,Neurology (clinical) ,medicine.symptom ,business - Abstract
To evaluate the risk of tonsillar herniation, the caudal pole of the cerebellar tonsil in posterior fossa mass lesions and anomalies was investigated with magnetic resonance imaging. The cerebellar tonsil was clearly demonstrated in relation to the surrounding structures on T1-weighted images in the paramedian or midline sagittal plane. In 78% of a control group of 50 cases, the tonsil was located just on or close to the upper border of the posterior lip of the foramen magnum. It was close to the line of the foramen magnum in 4 cases (8%), but displacement below this line was not observed in any case. In 18 cases of posterior fossa mass lesions, the tonsil tended to be in a lower position than in the control group, and tonsillar displacement below the foramen magnum was noted in 3 cases. Two of these cases had anterior medullary displacement with loss of the cerebrospinal fluid (CSF) space anterior to the tonsil; these patients had either rapid clinical deterioration or severe papilledema. In the remaining case and in 3 additional cases of Chiari malformation, the tonsils were displaced into the cervical canal with preservation of the CSF space, and the patients showed no signs of rapid clinical deterioration or increased intracranial pressure. The present study suggests that tonsillar displacement through the foramen magnum with associated anterior medullary displacement and loss of the CSF space anterior to the tonsil can be regarded as a sign of tonsillar herniation.
- Published
- 1988
297. Deep Supratentorial Arteriovenous Malformation Treated by Intraoperative Liquid Embolization
- Author
-
Haruhiko Kikuchi, Youichi Watanabe, Hisashi Shishido, Sen Yamagata, Izumi Nagata, Jun Karasawa, and Kenji Hashimoto
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Medicine ,Arteriovenous malformation ,Radiology ,Embolization ,business ,medicine.disease - Published
- 1987
298. Ipsilateral Atrophy in Children with Hemispheric Cerebral Tumors
- Author
-
Kozo Moritake, Masatsune Ishikawa, Kozo Mutoh, Haruki Mikawa, Masatoshi Ito, Tatsuya Fujii, Junkoh Yamashita, Haruhiko Kikuchi, and Takehiko Okuno
- Subjects
Male ,Nervous system ,Pathology ,medicine.medical_specialty ,Adolescent ,Astrocytoma ,Atrophy ,Cortex (anatomy) ,Basal ganglia ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Germinoma ,Brain Neoplasms ,business.industry ,Brain ,Infant ,Histology ,Anatomy ,medicine.disease ,medicine.anatomical_structure ,Child, Preschool ,Cerebral hemisphere ,Female ,Tomography, X-Ray Computed ,business ,Pinealoma - Abstract
The CT findings of 19 children under 16 years of age with primary brain tumors in the cerebral hemisphere were investigated with special reference to the existence of cerebral hemiatrophy ipsilateral to the side of the tumor. "Ipsilateral cerebral hemiatrophy" was observed in four of 19 cases (21%). These included two cases with germinoma in the basal ganglia and two with low-grade astrocytoma in the frontal and occipital cortex. This peculiar CT finding was not specific to the location or histology of the tumor. The four cases were characterized by slow progression, which contrasted with the rapid progression of tumors shown in seven cases with a mass effect on CT.
- Published
- 1988
299. Histopathological study of induced cerebral aneurysms in primates
- Author
-
Nobuo Hashimoto, Haruhiko Kikuchi, Choegon Kim, and Fumitada Hazama
- Subjects
medicine.medical_specialty ,Pathology ,Hypertension, Renal ,Pathogenesis ,chemistry.chemical_compound ,Renal Artery ,Aneurysm ,medicine.artery ,medicine ,Animals ,Carotid ligation ,cardiovascular diseases ,Renal artery ,Ligation ,business.industry ,Experimental model ,Intracranial Aneurysm ,Aminopropionitrile ,medicine.disease ,Macaca fascicularis ,Carotid Arteries ,chemistry ,cardiovascular system ,Female ,Surgery ,Histopathology ,Neurology (clinical) ,business - Abstract
Experimental cerebral aneurysms in monkeys induced by treating them with unilateral carotid ligation, renal hypertension, and beta-aminopropionitrile feeding were studied macroscopically and with light microscopy. Macroscopically, 13 cerebral aneurysms were observed in six of seven monkeys. Microscopically, the elastic lamina and the media ended around the beginning of the aneurysms. The thin aneurysmal walls consisted of fibrous connective tissues. All findings were generally in accordance with spontaneous lesions in humans. The induced cerebral aneurysms in primates are thought to be a suitable experimental model to clarify the pathogenesis of the disease.
- Published
- 1989
300. Relaxant effect of calcitonin gene-related peptide on cerebral arterial spasm induced by experimental subarachnoid hemorrhage in dogs
- Author
-
Noboru Mizuno, Shinichiro Okamoto, Haruhiko Kikuchi, Yoshihiko Uemura, and Kazuhiko Nozaki
- Subjects
Male ,Subarachnoid hemorrhage ,Calcitonin Gene-Related Peptide ,Cerebral arteries ,Vasodilation ,In Vitro Techniques ,Calcitonin gene-related peptide ,Cisterna magna ,Muscle, Smooth, Vascular ,Dogs ,Cerebral vasospasm ,Reference Values ,medicine ,Animals ,business.industry ,Cerebral Arteries ,Subarachnoid Hemorrhage ,medicine.disease ,Ischemic Attack, Transient ,Vasoconstriction ,Basilar Artery ,Anesthesia ,Arterial blood ,Female ,medicine.symptom ,business - Abstract
✓ This study examines the relaxant effect of calcitonin gene-related peptide (CGRP), a 37-amino acid peptide with a potent vasodilator action, on cerebral arterial spasm after subarachnoid hemorrhage (SAH). The spasm was induced by injecting autologous arterial blood percutaneously into the cisterna magna in adult mongrel dogs. The single-injection model of SAH was produced by injection of 1.0 ml/kg body weight of blood (on Day 0), and the double-injection model involved two successive injections of 0.5 ml/kg body weight of blood made 48 hours apart (on Day 0 and Day 2). On vertebral angiograms, arterial narrowing of the major cerebral arteries was most prominent on Day 3 after SAH in the single-injection model and on Day 7 in the double-injection model. When 10−10 mol/kg of CGRP was administered intracisternally in the single-injection model on Day 3, the diameter of the spastic cerebral arteries, as determined by angiography, recovered to normal. After intracisternal administration of 10−11 to 2 × 10−10 mol/kg of CGRP on Day 7 in double-injection models, spastic cerebral arteries dilated in a dose-dependent manner. The dilatory effect of CGRP continued for a few hours after administration. The results suggest that CGRP injected intracisternally may reverse cerebral arterial spasm after SAH.
- Published
- 1989
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.