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251. Output-based assessment of herd-level freedom from infection in endemic situations: Application of a Bayesian Hidden Markov model

Author

van Roon, A M, Madouasse, A, Toft, N, Santman-Berends, I M G A, Gethmann, J, Eze, J, Humphry, R W, Graham, D, Guelbenzu-Gonzalo, M, Nielen, M, More, S J, Mercat, M, Fourichon, C, Sauter-Louis, C, Frössling, J, Ågren, E, Gunn, G J, Henry, M K, van Schaik, G, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hydrologie, FAH Evidence based Veterinary Medicine, Dynamics of Innovation Systems, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hydrologie, FAH Evidence based Veterinary Medicine, and Dynamics of Innovation Systems

Subjects
Freedom, Freedom from infection, Diarrhea Viruses, Bovine Viral, Food Animals, Output-based surveillance, Animals, Cattle Diseases, Bayes Theorem, Bovine Virus Diarrhea-Mucosal Disease, Cattle, Animal Science and Zoology, Bovine viral diarrhoea virus, Control program
Abstract

Countries have implemented control programmes (CPs) for cattle diseases such as bovine viral diarrhoea virus (BVDV) that are tailored to each country-specific situation. Practical methods are needed to assess the output of these CPs in terms of the confidence of freedom from infection that is achieved. As part of the STOC free project, a Bayesian Hidden Markov model was developed, called STOC free model, to estimate the probability of infection at herd-level. In the current study, the STOC free model was applied to BVDV field data in four study regions, from CPs based on ear notch samples. The aim of this study was to estimate the probability of herd-level freedom from BVDV in regions that are not (yet) free. We additionally evaluated the sensitivity of the parameter estimates and predicted probabilities of freedom to the prior distributions for the different model parameters. First, default priors were used in the model to enable comparison of model outputs between study regions. Thereafter, country-specific priors based on expert opinion or historical data were used in the model, to study the influence of the priors on the results and to obtain country-specific estimates. The STOC free model calculates a posterior value for the model parameters (e.g. herd-level test sensitivity and specificity, probability of introduction of infection) and a predicted probability of infection. The probability of freedom from infection was computed as one minus the probability of infection. For dairy herds that were considered free from infection within their own CP, the predicted probabilities of freedom were very high for all study regions ranging from 0.98 to 1.00, regardless of the use of default or country-specific priors. The priors did have more influence on two of the model parameters, herd-level sensitivity and the probability of remaining infected, due to the low prevalence and incidence of BVDV in the study regions. The advantage of STOC free model compared to scenario tree modelling, the reference method, is that actual data from the CP can be used and estimates are easily updated when new data becomes available. European Food Safety Authority (EFSA) Dutch Ministry of Agriculture, Nature and Food Quality

Published
2022

253. Neonatal Asphyxia

Author

Gunn, Alistair J., Bennet, Laura, Clark, Robert S. B., editor, Carcillo, Joseph A., editor, Tisherman, Samuel A., editor, and Sterz, Fritz, editor

Published
2005
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256. NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells

Author

Maskalenka, Katsiaryna, primary, Alagöz, Gökberk, additional, Krueger, Felix, additional, Wright, Joshua, additional, Rostovskaya, Maria, additional, Nakhuda, Asif, additional, Bendall, Adam, additional, Krueger, Christel, additional, Walker, Simon, additional, Scally, Aylwyn, additional, and Rugg-Gunn, Peter J., additional

Published
2022
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262. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

Author

Ketcham, John M., primary, Haling, Jacob, additional, Khare, Shilpi, additional, Bowcut, Vickie, additional, Briere, David M., additional, Burns, Aaron C., additional, Gunn, Robin J., additional, Ivetac, Anthony, additional, Kuehler, Jon, additional, Kulyk, Svitlana, additional, Laguer, Jade, additional, Lawson, J. David, additional, Moya, Krystal, additional, Nguyen, Natalie, additional, Rahbaek, Lisa, additional, Saechao, Barbara, additional, Smith, Christopher R., additional, Sudhakar, Niranjan, additional, Thomas, Nicole C., additional, Vegar, Laura, additional, Vanderpool, Darin, additional, Wang, Xiaolun, additional, Yan, Larry, additional, Olson, Peter, additional, Christensen, James G., additional, and Marx, Matthew A., additional

Published
2022
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263. Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia

Author

Dhillon, Simerdeep K., primary, Gunn, Eleanor R., additional, Lear, Benjamin A., additional, King, Victoria J., additional, Lear, Christopher A., additional, Wassink, Guido, additional, Davidson, Joanne O., additional, Bennet, Laura, additional, and Gunn, Alistair J., additional

Published
2022
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269. Outcomes of transjugular intrahepatic portosystemic shunt using 12 mm diameter polytetrafluoroethylene covered stents in cirrhotic patients with portal hypertension

Author

Habash , Majd, Murray , Adrian, Heeke , Brenten, Mahmoud , Khalid, Li , Yufeng, Saddekni , Souheil, Aal , Ahmed K. Abdel, and Gunn , Andrew J.

Subjects
Liver Cirrhosis, Middle Aged, Esophageal and Gastric Varices, Treatment Outcome, Original Article Interventional Radiology, Hepatic Encephalopathy, Hypertension, Portal, Humans, Stents, Portasystemic Shunt, Transjugular Intrahepatic, Gastrointestinal Hemorrhage, Polytetrafluoroethylene, Aged, Retrospective Studies
Abstract

PURPOSE We aimed to evaluate the safety and efficacy of 12 mm diameter polytetrafluoroethylene (PTFE)- covered stents for the creation of transjugular intrahepatic portosystemic shunt (TIPS) in cir- rhotic patients with portal hypertension complicated by variceal bleeding and volume-overload. METHODS This retrospective study included 360 patients who had TIPS created between January 2004 and December 2017 using 12 mm diameter PTFE-covered stents. Demographic data, model for end- stage liver disease (MELD) score, etiology of cirrhosis, and Charlson comorbidity index were recorded. Symptoms of hepatic encephalopathy (HE), variceal re-bleeding, improvement in vol- ume-overload, TIPS revisions and the need for intervention, and overall survival were assessed. RESULTS The mean age of the patients was 56.8 ± 9.9 years, and the technical success rate was 99.4%. The rates of improvement of volume-overload post-TIPS were 59.5%, 69.8%, and 81.7% at 3, 6, and 12 months, respectively. About 93.3% of patients were free from paracentesis or thoracentesis at 12 months. The rates of re-bleeding post-TIPS were 4%, 12%, and 12.9% at 3, 6, and 12 months, respectively. The rate of TIPS revision at 12 months was 6.5%. Percentage of patients with any symptoms of HE were 34.4%, 42.9%, and 49.5% at 3, 6, and 12 months, respectively. All HE were appropriately medically managed and no patients required a TIPS reduction. CONCLUSION TIPS placement using 12 mm PTFE-covered stents is efficacious in cirrhotic patients with portal hypertension complicated by variceal bleeding or refractory volume-overload, with an accept- able safety profile.

Published
2022

270. Corrigendum: Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe

Author

Hodnik, Jaka Jakob, Acinger-Rogić, Žaklin, Alishani, Mentor, Autio, Tiina, Balseiro, Ana, Berezowski, John, Carmo, Luís Pedro, Chaligiannis, Ilias, Conrady, Beate, Costa, Lina, Cvetkovikj, Iskra, Davidov, Ivana, Dispas, Marc, Djadjovski, Igor, Duarte, Elsa Leclerc, Faverjon, Céline, Fourichon, Christine, Frössling, Jenny, Gerilovych, Anton, Gethmann, Jörn, Gomes, Jacinto, Graham, David, Guelbenzu, Maria, Gunn, George J., Henry, Madeleine K., Hopp, Petter, Houe, Hans, Irimia, Elena, Ježek, Jožica, Juste, Ramon A., Kalaitzakis, Emmanouil, Kaler, Jasmeet, Kaplan, Selcuk, Kostoulas, Polychronis, Kovalenko, Kaspars, Kneževič, Nada, Knific, Tanja, Koleci, Xhelil, Madouasse, Aurélien, Malakauskas, Alvydas, Mandelik, Rene, Meletis, Eleftherios, Mincu, Madalina, Mõtus, Kerli, Muñoz-Gómez, Violeta, Niculae, Mihaela, Nikitović, Jelena, Ocepek, Matjaž, Tangen-Opsal, Marie, Ózsvári, László, Papadopoulos, Dimitrios, Papadopoulos, Theofilos, Pelkonen, Sinikka, Polak, Miroslaw Pawel, Pozzato, Nicola, Rapaliuté, Eglé, Ribbens, Stefaan, Niza-Ribeiro, João, Roch, Franz Ferdinand, Rosenbaum Nielsen, Liza, Saez, Jose Luis, Nielsen, Søren Saxmose, van Schaik, Gerdien, Schwan, Ebba, Sekovska, Blagica, Starič, Jože, Strain, Sam, Šatran, Petr, Šerić-Haračić, Sabina, Tamminen, Lena Mari, Thulke, Hans Hermann, Toplak, Ivan, Tuunainen, Erja, Verner, Sharon, Vilček, Štefan, Yildiz, Ramazan, Santman-Berends, Inge M.G.A., FAH Evidence based Veterinary Medicine, dFAH AVR, and Dep Gezondheidszorg Landbouwhuisdieren

Subjects
control programmes, Europe, disease control, output-based standards, cattle, SOUND control, veterinary(all)
Abstract

A Corrigendum on Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe (Front. Vet. Sci., (2021), 8, (688078), 10.3389/fvets.2021.688078)

Published
2022

271. Neuroprotective therapies in the NICU in term infants: present and future

Author

Molloy, Eleanor J, El-Dib, Mohamed, Juul, Sandra E, Benders, Manon, Gonzalez, Fernando, Bearer, Cynthia, Wu, Yvonne W, Robertson, Nicola J, Hurley, Tim, Branagan, Aoife, Michael Cotten, C, Tan, Sidhartha, Laptook, Abbot, Austin, Topun, Mohammad, Khorshid, Rogers, Elizabeth, Luyt, Karen, Bonifacio, Sonia, Soul, Janet S, Gunn, Alistair J, and Newborn Brain Society Guidelines and Publications Committee

Subjects
Physical Injury - Accidents and Adverse Effects, Diseases, Hypothermia, Reproductive health and childbirth, Neurodegenerative, Pediatrics, Paediatrics and Reproductive Medicine, Neonatal, Hypoxia-Ischemia, Infant Mortality, Humans, Child, Pediatric, Induced, Neurosciences, Brain, Infant, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, Neuroprotection, Brain Disorders, Intensive Care Units, Neuroprotective Agents, Good Health and Well Being, Brain Injuries, Public Health and Health Services, Newborn Brain Society Guidelines and Publications Committee
Abstract

Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH. Although primary and delayed (secondary) brain injury starting in the latent phase after HI are major contributors to neurodisability, the very late evolving effects of tertiary brain injury likely require different interventions targeting neurorestoration. Clinical trials of seizure management and neuroprotection bundles are needed, in addition to current trials combining erythropoietin, stem cells, and melatonin with TH. IMPACT: The widespread use of therapeutic hypothermia (TH) in the treatment of neonatal encephalopathy (NE) has reduced the associated morbidity and mortality. However, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. This review details the pathophysiology of NE along with the evidence for the use of TH and other beneficial neuroprotective strategies used in term infants. We also discuss treatment strategies undergoing evaluation at present as potential adjuvant treatments to TH in NE.

Published
2022

272. Corrigendum: Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe

Author

FAH Evidence based Veterinary Medicine, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hodnik, Jaka Jakob, Acinger-Rogić, Žaklin, Alishani, Mentor, Autio, Tiina, Balseiro, Ana, Berezowski, John, Carmo, Luís Pedro, Chaligiannis, Ilias, Conrady, Beate, Costa, Lina, Cvetkovikj, Iskra, Davidov, Ivana, Dispas, Marc, Djadjovski, Igor, Duarte, Elsa Leclerc, Faverjon, Céline, Fourichon, Christine, Frössling, Jenny, Gerilovych, Anton, Gethmann, Jörn, Gomes, Jacinto, Graham, David, Guelbenzu, Maria, Gunn, George J., Henry, Madeleine K., Hopp, Petter, Houe, Hans, Irimia, Elena, Ježek, Jožica, Juste, Ramon A., Kalaitzakis, Emmanouil, Kaler, Jasmeet, Kaplan, Selcuk, Kostoulas, Polychronis, Kovalenko, Kaspars, Kneževič, Nada, Knific, Tanja, Koleci, Xhelil, Madouasse, Aurélien, Malakauskas, Alvydas, Mandelik, Rene, Meletis, Eleftherios, Mincu, Madalina, Mõtus, Kerli, Muñoz-Gómez, Violeta, Niculae, Mihaela, Nikitović, Jelena, Ocepek, Matjaž, Tangen-Opsal, Marie, Ózsvári, László, Papadopoulos, Dimitrios, Papadopoulos, Theofilos, Pelkonen, Sinikka, Polak, Miroslaw Pawel, Pozzato, Nicola, Rapaliuté, Eglé, Ribbens, Stefaan, Niza-Ribeiro, João, Roch, Franz Ferdinand, Rosenbaum Nielsen, Liza, Saez, Jose Luis, Nielsen, Søren Saxmose, van Schaik, Gerdien, Schwan, Ebba, Sekovska, Blagica, Starič, Jože, Strain, Sam, Šatran, Petr, Šerić-Haračić, Sabina, Tamminen, Lena Mari, Thulke, Hans Hermann, Toplak, Ivan, Tuunainen, Erja, Verner, Sharon, Vilček, Štefan, Yildiz, Ramazan, Santman-Berends, Inge M.G.A., FAH Evidence based Veterinary Medicine, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hodnik, Jaka Jakob, Acinger-Rogić, Žaklin, Alishani, Mentor, Autio, Tiina, Balseiro, Ana, Berezowski, John, Carmo, Luís Pedro, Chaligiannis, Ilias, Conrady, Beate, Costa, Lina, Cvetkovikj, Iskra, Davidov, Ivana, Dispas, Marc, Djadjovski, Igor, Duarte, Elsa Leclerc, Faverjon, Céline, Fourichon, Christine, Frössling, Jenny, Gerilovych, Anton, Gethmann, Jörn, Gomes, Jacinto, Graham, David, Guelbenzu, Maria, Gunn, George J., Henry, Madeleine K., Hopp, Petter, Houe, Hans, Irimia, Elena, Ježek, Jožica, Juste, Ramon A., Kalaitzakis, Emmanouil, Kaler, Jasmeet, Kaplan, Selcuk, Kostoulas, Polychronis, Kovalenko, Kaspars, Kneževič, Nada, Knific, Tanja, Koleci, Xhelil, Madouasse, Aurélien, Malakauskas, Alvydas, Mandelik, Rene, Meletis, Eleftherios, Mincu, Madalina, Mõtus, Kerli, Muñoz-Gómez, Violeta, Niculae, Mihaela, Nikitović, Jelena, Ocepek, Matjaž, Tangen-Opsal, Marie, Ózsvári, László, Papadopoulos, Dimitrios, Papadopoulos, Theofilos, Pelkonen, Sinikka, Polak, Miroslaw Pawel, Pozzato, Nicola, Rapaliuté, Eglé, Ribbens, Stefaan, Niza-Ribeiro, João, Roch, Franz Ferdinand, Rosenbaum Nielsen, Liza, Saez, Jose Luis, Nielsen, Søren Saxmose, van Schaik, Gerdien, Schwan, Ebba, Sekovska, Blagica, Starič, Jože, Strain, Sam, Šatran, Petr, Šerić-Haračić, Sabina, Tamminen, Lena Mari, Thulke, Hans Hermann, Toplak, Ivan, Tuunainen, Erja, Verner, Sharon, Vilček, Štefan, Yildiz, Ramazan, and Santman-Berends, Inge M.G.A.

Published
2022

273. Output-based assessment of herd-level freedom from infection in endemic situations: Application of a Bayesian Hidden Markov model

Author

dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hydrologie, FAH Evidence based Veterinary Medicine, Dynamics of Innovation Systems, van Roon, A M, Madouasse, A, Toft, N, Santman-Berends, I M G A, Gethmann, J, Eze, J, Humphry, R W, Graham, D, Guelbenzu-Gonzalo, M, Nielen, M, More, S J, Mercat, M, Fourichon, C, Sauter-Louis, C, Frössling, J, Ågren, E, Gunn, G J, Henry, M K, van Schaik, G, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, Hydrologie, FAH Evidence based Veterinary Medicine, Dynamics of Innovation Systems, van Roon, A M, Madouasse, A, Toft, N, Santman-Berends, I M G A, Gethmann, J, Eze, J, Humphry, R W, Graham, D, Guelbenzu-Gonzalo, M, Nielen, M, More, S J, Mercat, M, Fourichon, C, Sauter-Louis, C, Frössling, J, Ågren, E, Gunn, G J, Henry, M K, and van Schaik, G

Published
2022

274. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Author

Zijlmans, D.W., Talon, Irene, Verhelst, Sigrid, Bendall, Adam, Nerum, Karlien Van, Admiraal, Danielle, Javali, Alok, Knops, R., Jansen, J.H., Vermeulen, M., Marks, H., Rugg-Gunn, Peter J., Pasque, Vincent, Zijlmans, D.W., Talon, Irene, Verhelst, Sigrid, Bendall, Adam, Nerum, Karlien Van, Admiraal, Danielle, Javali, Alok, Knops, R., Jansen, J.H., Vermeulen, M., Marks, H., Rugg-Gunn, Peter J., and Pasque, Vincent

Abstract

Contains fulltext : 251360.pdf (Publisher’s version ) (Open Access)

Published
2022

281. ACR Appropriateness Criteria® Thoracoabdominal Aortic Aneurysm or Dissection: Treatment Planning and Follow-Up.

Author

Contrella, Benjamin N., Khaja, Minhajuddin S., Majdalany, Bill S., Kim, Charles Y., Kalva, Sanjeeva P., Beck, Adam W., Browne, William F., Clough, Rachel E., Ferencik, Maros, Fleischman, Fernando, Gunn, Andrew J., Hickey, Sean M., Kandathil, Asha, Kim, Karen M., Monroe, Eric J., Ochoa Chaar, Cassius Iyad, Scheidt, Matthew J., Smolock, Amanda R., Steenburg, Scott D., and Waite, Kathleen

Abstract

As the incidence of thoracoabdominal aortic pathology (aneurysm and dissection) rises and the complexity of endovascular and surgical treatment options increases, imaging follow-up of patients remains crucial. Patients with thoracoabdominal aortic pathology without intervention should be monitored carefully for changes in aortic size or morphology that could portend rupture or other complication. Patients who are post endovascular or open surgical aortic repair should undergo follow-up imaging to evaluate for complications, endoleak, or recurrent pathology. Considering the quality of diagnostic data, CT angiography and MR angiography are the preferred imaging modalities for follow-up of thoracoabdominal aortic pathology for most patients. The extent of thoracoabdominal aortic pathology and its potential complications involve multiple regions of the body requiring imaging of the chest, abdomen, and pelvis in most patients. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation. [ABSTRACT FROM AUTHOR]

Published
2023
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282. How to Apply Variable Selection Machine Learning Algorithms With Multiply Imputed Data: A Missing Discussion.

Author

Gunn, Heather J., Rezvan, Panteha Hayati, Fernández, M. Isabel, and Comulada, W. Scott

Abstract

Psychological researchers often use standard linear regression to identify relevant predictors of an outcome of interest, but challenges emerge with incomplete data and growing numbers of candidate predictors. Regularization methods like the LASSO can reduce the risk of overfitting, increase model interpretability, and improve prediction in future samples; however, handling missing data when using regularization-based variable selection methods is complicated. Using listwise deletion or an ad hoc imputation strategy to deal with missing data when using regularization methods can lead to loss of precision, substantial bias, and a reduction in predictive ability. In this tutorial, we describe three approaches for fitting a LASSO when using multiple imputation to handle missing data and illustrate how to implement these approaches in practice with an applied example. We discuss implications of each approach and describe additional research that would help solidify recommendations for best practices. [ABSTRACT FROM AUTHOR]

Published
2023
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283. Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury.

Author

Lear, Christopher A, Lear, Benjamin A, Davidson, Joanne O, Sae-Jiw, Jialin, Lloyd, Johanna M, Dhillon, Simerdeep K, Gunn, Alistair J, and Bennet, Laura

Subjects
WHITE matter (Nerve tissue), MYELIN proteins, PARIETAL lobe, NECROSIS, FETAL anoxia, PREMATURE infants
Abstract

Cystic white matter injury is highly associated with severe neurodevelopmental disability and cerebral palsy in preterm infants, yet its pathogenesis remains poorly understood and there is no established treatment. In the present study, we tested the hypothesis that slowly evolving cystic white matter injury after hypoxia-ischaemia is mediated by programmed necrosis initiated by tumour necrosis factor. Tumour necrosis factor blockade was begun 3 days after hypoxia-ischaemia to target the tertiary phase of injury, when most secondary cell death is thought to be complete. Chronically instrumented preterm foetal sheep (0.7 gestation) received 25 min of hypoxia-ischaemia induced by complete umbilical cord occlusion or sham-umbilical cord occlusion (controls, n = 10), followed by intracerebroventricular infusion of the soluble TNF inhibitor, Etanercept, at 3, 8 and 13 days after umbilical cord occlusion (n = 9) or vehicle (n = 9). Foetal brains were processed for histology at 21 days after umbilical cord occlusion. Umbilical cord occlusion with vehicle was associated with a spectrum of macroscopic white matter degeneration, including white matter atrophy, ventriculomegaly and overt temporal lobe cystic white matter injury. Oligodendrocyte maturational arrest and impaired labelling of myelin proteins, characteristic of diffuse white matter injury, was observed in the parietal lobe and surrounding the cystic lesions in the temporal lobe. Etanercept markedly attenuated cystic white matter injury on the side of the intracerebroventricular infusion, with partial contralateral protection. Further, Etanercept improved oligodendrocyte maturation and labelling of myelin proteins in the temporal and parietal lobes. The present study shows that cystic white matter injury reflects late-onset tertiary cell death mediated by delayed neuroinflammation through the tumour necrosis factor pathway. Delayed tumour necrosis factor blockade markedly attenuated cystic white matter injury and restored oligodendrocyte maturation and deficits in myelin protein expression. These data suggest that delayed tumour necrosis factor blockade may represent a viable therapeutic strategy to reduce the risk of cystic and diffuse white matter injury and potentially cerebral palsy after preterm birth, with a surprisingly wide therapeutic window. [ABSTRACT FROM AUTHOR]

Published
2023
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288. Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells

Author

Novo, Clara Lopes, primary, Wong, Emily V., additional, Hockings, Colin, additional, Poudel, Chetan, additional, Sheekey, Eleanor, additional, Wiese, Meike, additional, Okkenhaug, Hanneke, additional, Boulton, Simon J., additional, Basu, Srinjan, additional, Walker, Simon, additional, Kaminski Schierle, Gabriele S., additional, Narlikar, Geeta J., additional, and Rugg-Gunn, Peter J., additional

Published
2022
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290. Abstract ND02: MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers

Author

Ketcham, John M., primary, Khare, Shilpi, additional, Sudhakar, Niranjan, additional, Briere, David M., additional, Yan, Larry, additional, Laguer, Jade, additional, Vegar, Laura, additional, Vanderpool, Darin, additional, Hallin, Jill, additional, Hargis, Lauren, additional, Bowcut, Vickie, additional, Lawson, David, additional, Gunn, Robin J., additional, Ivetac, Anthony, additional, Thomas, Nicole C., additional, Saechao, Barbara, additional, Nguyen, Natalie, additional, Clarine, Jeffrey, additional, Rahbaek, Lisa, additional, Smith, Christopher R., additional, Burns, Aaron C., additional, Marx, Matthew A., additional, Christensen, James G., additional, Olson, Peter, additional, and Haling, Jacob R., additional

Published
2022
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291. Abstract LB505: Design and discovery of MRTX0902, a potent, selective, and orally bioavailable SOS1 inhibitor

Author

Ketcham, John M., primary, Briere, David M., additional, Burns, Aaron C., additional, Christensen, James G., additional, Gunn, Robin J., additional, Haling, Jacob, additional, Ivetac, Anthony, additional, Khare, Shilpi, additional, Kuehler, Jon, additional, Kulyk, Svitlana, additional, Laguer, Jade, additional, Lawson, John D., additional, Moya, Krystal, additional, Nguyen, Natalie, additional, Olson, Peter, additional, Rahbaek, Lisa, additional, Smith, Christopher R., additional, Sudhakar, Niranjan, additional, Thomas, Nicole C., additional, Vanderpool, Darin, additional, Wang, Xiaolun, additional, and Marx, Matthew A., additional

Published
2022
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296. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Author

Zijlmans, Dick W., primary, Talon, Irene, additional, Verhelst, Sigrid, additional, Bendall, Adam, additional, Van Nerum, Karlien, additional, Javali, Alok, additional, Malcolm, Andrew A., additional, van Knippenberg, Sam S. F. A., additional, Biggins, Laura, additional, To, San Kit, additional, Janiszewski, Adrian, additional, Admiraal, Danielle, additional, Knops, Ruth, additional, Corthout, Nikky, additional, Balaton, Bradley P., additional, Georgolopoulos, Grigorios, additional, Panda, Amitesh, additional, Bhanu, Natarajan V., additional, Collier, Amanda J., additional, Fabian, Charlene, additional, Allsop, Ryan N., additional, Chappell, Joel, additional, Pham, Thi Xuan Ai, additional, Oberhuemer, Michael, additional, Ertekin, Cankat, additional, Vanheer, Lotte, additional, Athanasouli, Paraskevi, additional, Lluis, Frederic, additional, Deforce, Dieter, additional, Jansen, Joop H., additional, Garcia, Benjamin A., additional, Vermeulen, Michiel, additional, Rivron, Nicolas, additional, Dhaenens, Maarten, additional, Marks, Hendrik, additional, Rugg-Gunn, Peter J., additional, and Pasque, Vincent, additional

Published
2022
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299. Basivertebral Nerve Ablation

Author

Huang, Junjian, additional, Delijani, Kevin, additional, Jones, Jesse, additional, Di Capua, John, additional, El Khudari, Husamuddin, additional, Gunn, Andrew J., additional, and Hirsch, Joshua A., additional

Published
2022
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