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1,387 results on '"Groß, U."'

253. Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

Author

Kranz, I., primary, Gonzalez, J. B., additional, Dörfel, I., additional, Gemeinert, M., additional, Griepentrog, M., additional, Klaffke, D., additional, Knabe, C., additional, Österle, W., additional, and Gross, U., additional

Published
2008
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257. Taenia-crassiceps-Infektion bei AIDS

Author

Klinker, H., primary, Tintelnot, K., additional, Joeres, R., additional, Müller, J., additional, Groß, U., additional, Schmidt-Rotte, H., additional, Landwehr, P., additional, and Richter, E., additional

Published
2008
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259. The development of a posttransplant TLI treatment strategy that promotes organ allograft acceptance without chronic immunosuppression

Author

Gross U, Carver M, D Araneda, M. Alqaisi, Frank T. Thomas, Timothy Patselas, Lorita M. Rebellato, Paul Cunningham, and Judith M. Thomas

Subjects
Antigens, Differentiation, T-Lymphocyte, Male, medicine.medical_specialty, CD3 Complex, Lymphoid Tissue, medicine.medical_treatment, CD8 Antigens, Splenectomy, Urology, Receptors, Antigen, T-Cell, Immune tolerance, Leukocyte Count, Pharmacotherapy, Transplantation Immunology, medicine, Animals, Transplantation, Homologous, Antilymphocyte Serum, Immunosuppression Therapy, Transplantation, business.industry, Graft Survival, Antibody-Dependent Cell Cytotoxicity, Immunosuppression, Kidney Transplantation, Macaca mulatta, Nephrectomy, Lymphocyte Subsets, Surgery, Antibodies, Anti-Idiotypic, Radiation therapy, Immunosuppressive drug, Antibody Formation, CD4 Antigens, business
Abstract

The effectiveness of fractionated TLI in promoting allograft tolerance without chronic drug therapy is well established experimentally. TLI has not been widely applied in clinical transplantation, largely due to logistic and medical limitations of pretransplant TLI conditioning. Potential use of posttransplant TLI (PT-TLI) has not been critically evaluated. In this study we investigated PT-TLI in combination with rabbit antithymocyte globulin (RATG) in the absence of chronic immunosuppressive drugs as a strategy for inducing long-term kidney allograft acceptance. Recipients were studied with and without infusion of DR-CD3- donor bone marrow cells (DBMC). Normal rhesus monkeys, which received no pretransplant treatment, underwent bilateral intrinsic nephrectomy and splenectomy at the time of transplantation. RATG was administered daily for 3-5 consecutive days beginning on day 0. A total dose of 500-625 cGy of fractionated TLI was given in 4-5 treatments at 125 cGy per day beginning on day +1. Whereas neither PT-TLI nor RATG monotherapy induced long-term graft acceptance in splenectomized recipients, the combination of these modalities was remarkable in promoting long-term allograft acceptance without immunosuppressive drug therapy. Of 4 recipients given RATG x 5, splenectomy and PT-TLI, all were free of acute rejection. Of these, 3/4 had graft survivals greater than 100 days, 2/4 were greater than 150 days and 1/4 greater than 365 days. Of 5 recipients given this treatment plus an infusion of DR-CD3-DBMC, 4/5 grafts survived greater than 150 days and 3/5 still have normal functioning grafts at greater than 365 days. PT-TLI accentuated and prolonged changes in PBL subpopulations that were initially affected by RATG. Depressed levels of CD3+ cells were present for 4-5 months, with large numbers of circulating CD4+CD3- and especially CD8+ CD3- cells. In addition, antibody responses to RATG and alloantigens were suppressed in PT-TLI-treated recipients. Overall, the combination of PT-TLI, splenectomy, and RATG was found to be effective in promoting long-term allograft acceptance without chronic immunosuppressive drug therapy. The infusion of DR-CD3- DBMC in recipients treated with PT-TLI, RATG and splenectomy appeared to further increase the incidence of stable long-term survivors. If infectious complications can be improved, this approach may provide a clinically applicable posttransplant treatment strategy for inducing functional allograft tolerance.

Published
1992

260. The Incorporation of Glass-Ceramic Implants in Bone after Surface Conditioning Glow-Discharge Treatment

Author

Muller-Mai, C. M., Voigt, C., Baier, R. E., and Gross, U. M.

Subjects
histology, implant, glow-discharge, glass-ceramic, Bone, ultrastructure, morphometry, Biomedical Engineering and Bioengineering
Abstract

Glow discharge (GD)-treated and autoclaved glass-ceramics of bone-bonding and non-bonding type were implanted into the femoral diaphysis of rats for 3, 7, 14 and 28 days and were investigated by applying light microscopy and histomorphometry , and scanning and transmission electron microscopy. More bone and chondroid, and faster osteoid development were observed at glow-discharge treated implants even in nonbonding implants when compared to autoclaved controls. Ultrastructural investigations showed a higher leach ing- rate of GD-treated bone-bonding implants during the early days after implantation leading to a higher rugosity, whereas no morphological changes were observed on non-bonding implant surfaces. More extracellular matrix (ECM) forming productive cells and less macrophages were observed on GD-sterilized implant surfaces. Osteoclast-like cells were detected exclusively at 3 and 7 days post-operatively on GD-sterilized bone-bonding implants. The higher amount of bone at GD-treated surfaces was thought to be due to a higher leaching rate leading to higher surface-rugosity and interface alkalinity. Thus, GD-treatment seems to be suitable for sterilization of surface-reactive implants to yield earlier functionality and to reduce possible degradative processes.

Published
1992

261. Phospholipid vesiculated fluorocarbons--promising trend in blood substitutes

Author

H. Reichelt, Rüdiger S, Gross U, and Draffehn J

Subjects
Liposome, Fluorocarbons, Chromatography, Viscosity, Vesicle, Phospholipid, General Medicine, chemistry.chemical_compound, nervous system, chemistry, Drug Stability, Blood Substitutes, Liposomes, Phosphatidylcholines, Poloxalene, Emulsions
Abstract

Dispersions of fluorocarbons (PFC's) made with phospholipids have unusual properties, e.g. very high stability, due to the formation of thermodynamically stable vesicles. They can be used for high PFC concentrations as well as e.g. for ESR imaging.

Published
1992

262. Professor Erich Hahne on his 75th birthday

Author

Müller-Steinhagen, H., primary, Spindler, K., additional, Minkowycz, W.J., additional, Goldstein, R.J., additional, Gross, U., additional, Stephan, K., additional, Mayinger, F., additional, Heidemann, W., additional, Hewitt, G.F., additional, and Martynenko, O.G., additional

Published
2007
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271. Incorporation and Degradation of Hydroxyapatite Implants of Different Surface Roughness and Surface Structure in Bone

Author

Müller-Mai, C. M., Voigt, C., and Gross, U.

Subjects
Corrosion, Degradation, Surface roughness, Leaching, Implant, Life Sciences, Bone, Hydroxyapatite, Resorption
Abstract

The interface of dense hydroxyapatite (HA) implants with different surface roughnesses was investigated after implantation into the spongy bone of the distal femur of rabbits by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) following transverse fractures in the interface. Each implant displayed considerable changes in surface morphology caused by leaching (increasing pore diameter), corrosion (particulate disintegration), and active resorption by osteoclasts. Macrophages were involved in "cleaning" the surface via phagocytosis of loose implant particles. Newly formed surface elevations provided adhesion points for fibers and fibrils. Subsequent mineralization of these areas stabilized the interdigitation of surface elevations and extracellular matrix with adhering fibers and contributed to the tensile strength in the interface. This investigation provides further knowledge about HA implants, which seem to be partially resorbed by osteoclast-like cells.

Published
1990

272. Kardiomyopathien

Author

Schultheiss, H.-P., primary, Noutsias, M., additional, Kühl, U., additional, Gross, U., additional, Lassner, D., additional, Poller, W., additional, and Pauschinger, M., additional

Published
2005
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284. DEVELOPMENT OF MEMBRANES FOR BIOARTIFICIAL ORGANS

Author

Groth, Th., primary, Fey-Lamprecht, F., additional, Seifert, B., additional, Mihanetzis, G., additional, Malsch, G., additional, Albrecht, W., additional, Gross, U., additional, Missirlis, Y., additional, and Paul, D., additional

Published
2000
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