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1,970 results on '"Gale, C"'

252. The harm of anticoagulation in patients with low-risk by CHADS2 and reclassified as high-risk by CHA2DS2VASc: inferences from TRAF cohort

Author

Oto, E, Okutucu, S, Katircioglu Öztürk, D, Ata, N, Yavuz, B, Gale, C, Burkan, A, Camm, J, and Oto, A

Abstract

OBJECTIVE: There is a gap in the knowledge concerning oral anticoagulation (OAC) in atrial fibrillation (AF) patients with a non-high risk of stroke. CHA2DS2VASc and CHADS2 scores generated imprecise risk estimates for low risk patients. We aimed to assess OAC in patients with low risk by CHADS2 and reclassified as high-risk by CHA2DS2VASc. PATIENTS AND METHODS: In this study, retrospective nationwide population-based study, data were obtained from the Turkish claims and utilization management system. Patients with non-valvular AF (n=451,113) between 2007 and 2012 sub-divided into those with a CHA2DS2VASc≥1 and CHADS2=0 (n=41,273) who were off-warfarin (n=29,448) and on-warfarin (n=11,825). Stroke and systemic embolism, major bleeding, all-cause mortality, net clinical benefit (NCB) and ultimate NCB (UNCB) were assessed. RESULTS: Of the total cohort (mean age 66.1 ± 14.1 years, 56.1% female), CHA2DS2VASc improved the net reclassification index of observed 5-year composite thromboembolic endpoint by 6.9% (p

Published
2020

253. A core outcome set for pre‐eclampsia research : an international consensus development study

Author

Duffy, JMN, Cairns, AE, Richards‐Doran, D, van 't Hooft, J, Gale, C, Brown, M, Chappell, LC, Grobman, WA, Fitzpatrick, R, Karumanchi, SA, Khalil, A, Lucas, DN, Magee, LA, Mol, BW, Stark, M, Thangaratinam, S, Wilson, MJ, von Dadelszen, P, Williamson, PR, Ziebland, S, McManus, RJ, Abalos, EJ, Adamson, CCD, Akadri, AA, Akturk, Z, Allegaert, K, Angel‐Müller, E, Antretter, J, Audibert, F, Auger, N, Aygun, C, Babic, I, Bagga, R, Baker, JM, Bhandari, V, Bhattacharya, S, Blanker, MH, Bloomfield, FH, Bof, A, Brennan, SM, Broekhuijsen, K, Fiona Broughton Pipkin, E, Browne, JL, Browning, RM, Bull, JW, Butt, A, Button, D, Campbell, JP, Campbell, DM, Carbillon, L, Carthy, S, Casely, E, Cave, JA, Cecatti, JG, Chamillard, ME, Chassard, D, Checheir, NC, Chulkov, VS, Cluver, CA, Crawford, CF, Daly, MC, Darmochwal‐Kolarz, DA, Davies, RE, Davies, MW, Dawson, JS, Dobson, N, Dodd, CN, Donald, F, Duley, L, Epstein‐Mares, J, Erez, O, Evans, E, Farlie, RN, Ferris, AV, Frankland, EM, Freeman, DJ, Gainder, S, Ganzevoort, W, Gbinigie, OA, Ghosh, SK, Glogowska, M, Goodlife, A, Gough, KL, Green, JR, Gul, F, Haggerty, L, Hall, DR, Hallman, M, Hammond, SJ, Harlow, SD, Hays, KE, Hickey, SC, Higgins, M, Hinton, L, Hobson, SR, Hogg, MJ, Hollands, HJ, Homer, CSE, Hoodbhoy, Z, Howell, P, Huppertz, B, Husain, S, Jacoby, SD, Jacqz‐Aigrain, E, Jenkins, G, Jewel, D, Johnson, MJ, Johnston, CL, Jones, PM, Kantrowitz‐Gordon, I, Khan, R, Kirby, LJ, Kirk, C, Knight, M, Korey, MT, Lee, GJ, Lee, VW, Levene, LS, Londero, AP, Lust, KM, MacKenzie, V, Malha, L, Mattone, M, McCartney, DE, McFadden, A, McKinstry, BH, Middleton, PF, Mistry, HD, Mitchell, CA, Mockler, JC, Molsher, S, Monast, ES, Moodley, J, Mooij, R, Moore, EL, Morgan, L, Moulson, A, Mughal, F, Mundle, SR, Angel Munoz, M, Murray, E, Nagata, C, Nair, AS, Nakimuli, A, Nath, G, Newport, RS, Oakeshott, P, Ochoa‐Ferraro, MR, Odendaal, H, Ohkuchi, A, Oliveira, L, Ortiz‐Panozo, E, Oudijk, MA, Oygucu, SE, Paech, MJ, Painter, RC, Parry, CL, Payne, BA, Pearson, EL, Phupong, V, Pickett, N, Pickles, KA, Plumb, LK, Prefumo, F, Preston, R, Ray, JG, Rayment, J, Regan, LV, Rey, E, Robson, EJ, Rubin, AN, Rubio‐Romero, JA, Rull, K, Sass, N, Sauvé, N, Savory, NA, Scott, JR, Seaton, SE, Seed, PT, Shakespeare, JM, Shand, AW, Sharma, S, Shaw, TY, Smedley, KL, Smith, D, Smith Conk, A, Soward, D, Stepan, H, Stroumpoulis, K, Surendran, A, Takeda, S, Tan, L, Theriot, BS, Thomas, HF, Thompson, K, Thompson, PI, Thompson, MJ, Torney, KLHT, Treadwell, JS, Tucker, KL, Turrentine, MA, Van Hecke, O, Van Oostwaard, MF, Vasquez, DN, Vaughan, DJA, VInturache, A, Walker, J, Wardle, SP, Wasim, T, Waters, JH, Whitehead, CL, Wolfson, A, Yeo, S, and Zermansky, AG

Subjects
reproductive and urinary physiology
Abstract

Objective\ud To develop a core outcome set for pre‐eclampsia.\ud \ud Design\ud Consensus development study.\ud \ud Setting\ud International.\ud \ud Population\ud Two hundred and eight‐one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.\ud \ud Methods\ud Modified Delphi method and Modified Nominal Group Technique.\ud \ud Results\ud A long‐list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre‐eclampsia trials with those derived from thematic analysis of 30 in‐depth interviews of women with lived experience of pre‐eclampsia. Forty‐seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small‐for‐gestational‐age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.\ud \ud Conclusions\ud The core outcome set for pre‐eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.

Published
2020

254. Trends of in-hospital and 30-day mortality after percutaneous coronary intervention in England before and after the COVID-19 era

Author

Mohamed, MO, Kinnaird, T, Curzen, N, Ludman, P, Wu, J, Rashid, M, Shoaib, A, de Belder, M, Deanfield, J, Gale, C, and Mamas, M

Subjects
RA0421, R735, RC666, R1, RA
Abstract

Objectives: To examine short-term primary causes of death after percutaneous coronary intervention (PCI) in a national cohort before and during COVID-19. Background: Public reporting of PCI outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and what proportion of these are attributable to cardiac causes. Methods: All patients undergoing PCI in England between 1st January 2017 and 10th May 2020 were retrospectively analysed (n=273,141), according to their outcome from the date of PCI; no death and in-hospital, post-discharge, and 30-day death. Results: The overall rates of in-hospital and 30-day death were 1.9% and 2.8%, respectively. The rate of 30-day death declined between 2017 (2.9%) and February 2020 (2.5%), mainly due to lower in-hospital death (2.1% vs. 1.5%), before rising again from 1st March 2020 (3.2%) due to higher rates of post-discharge mortality. Only 59.6% of 30-day deaths were due to cardiac causes, the most common being acute coronary syndrome, cardiogenic shock and heart failure, and this persisted throughout the study period. 10.4% of 30-day deaths after 1st March 2020 were due to confirmed COVID-19. Conclusions: In this nationwide study, we show that 40% of 30-day deaths are due to non-cardiac causes. Non-cardiac deaths have increased even more from the start of the COVID-19 pandemic, with one in ten deaths from March 2020 being COVID-19 related. These findings raise a question of whether public reporting of PCI outcomes should be cause-specific.

Published
2020

255. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study

Author

Knight, M, Bunch, K, Vousden, N, Morris, E, Simpson, N, Gale, C, O'Brien, P, Quigley, M, Brocklehurst, P, Kurinczuk, JJ, and Group, UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative

Subjects
Adult, medicine.medical_specialty, Pneumonia, Viral, Overweight, law.invention, 1117 Public Health and Health Services, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Medicine, General & Internal, law, Pregnancy, Risk Factors, General & Internal Medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Pregnancy Complications, Infectious, Prospective cohort study, Pandemics, Minority Groups, 030219 obstetrics & reproductive medicine, Science & Technology, business.industry, Obstetrics, Cesarean Section, SARS-CoV-2, Incidence (epidemiology), Incidence, COVID-19, 1103 Clinical Sciences, General Medicine, medicine.disease, Intensive care unit, UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group, Confidence interval, United Kingdom, Hospitalization, Premature birth, INFLUENZA, Premature Birth, Maternal death, Female, medicine.symptom, business, Coronavirus Infections, Life Sciences & Biomedicine
Abstract

ObjectivesTo describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants.DesignProspective national population based cohort study using the UK Obstetric Surveillance System (UKOSS).SettingAll 194 obstetric units in the UK.Participants427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020.Main outcome measuresIncidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission.ResultsThe estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth.ConclusionsMost pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation.Study registrationISRCTN 40092247.

Published
2020

256. National active surveillance to understand and inform neonatal care in COVID-19

Author

Gale, C, Knight, M, Ladhani, S, Draper, ES, Sharkey, D, Doherty, C, Mactier, H, Kurinczuk, JJ, Group, Members of Neonatal Complications of COVID-19 Surveillance, and National Institute of Health Research Policy Research Programme

Subjects
medicine.medical_specialty, Pediatrics, Population, Pneumonia, Viral, Disease, neonatology, 03 medical and health sciences, Betacoronavirus, Viewpoint, 0302 clinical medicine, 030225 pediatrics, Obstetrics and Gynaecology, Epidemiology, medicine, Humans, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, Neonatology, education, Pandemics, Pregnancy, education.field_of_study, Infection Control, SARS-CoV-2, business.industry, Transmission (medicine), Infant, Newborn, COVID-19, Obstetrics and Gynecology, General Medicine, medicine.disease, United Kingdom, Neonatal infection, Perinatal Care, Pediatrics, Perinatology and Child Health, Epidemiological Monitoring, Infant Care, Members of Neonatal Complications of COVID-19 Surveillance Group, 1114 Paediatrics and Reproductive Medicine, epidemiology, business, Coronavirus Infections, Horizontal transmission
Abstract

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has spread rapidly. COVID-19 was declared a pandemic by the WHO on 12 March 2020. Robust, population-based data describing COVID-19 during pregnancy and the neonatal period are critical to understand and manage this global threat in these groups. There are three key ways that SARS-CoV-2 could affect neonates: 1. Vertical transmission of SARS-CoV-2 from mother to infant, which may lead to neonatal COVID-19. 2. Horizontal transmission of SARS-CoV-2 in the neonatal period, potentially leading to neonatal COVID-19; this may occur from family contacts or nosocomial transmission in healthcare settings, such as neonatal units. 3. Indirect effects on the newborn following maternal COVID-19 that impact pregnancy or labour and birth, leading to complications, such as preterm birth. This will include situations where the neonate is affected by, but does not contract, SARS-CoV-2. The impact of COVID-19 on neonates, as well as the importance of these different potential mechanisms of exposure, remains unclear. Vertical transmission of SARS-CoV-2 has yet to be definitively established; neonatal infection with the virus has been detected in the first days after birth to mothers with COVID-191; however, this could represent early horizontal transmission. Support for vertical transmission comes from serological testing following maternal COVID-19, which found SARS-CoV-2 IgM in umbilical cord blood2; however, SARS-CoV-2 viral RNA was not detected in these newborns, and the validity of current serological tests remains to be established.3 Nevertheless, neonates can be symptomatic with COVID-19 regardless of the mechanism of transmission. Although initial data indicated that the disease was less severe in children,4 approximately 10% of neonates and infants with COVID-19 develop severe or critical disease, a higher proportion than that in …

Published
2020

257. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Author

Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., Huikuri, H. V., Johansson, I., Juni, P., Lettino, M., Marx, N., Mellbin, L. G., Ostgren, C. J., Rocca, Bianca, Roffi, M., Sattar, N., Seferovic, P. M., Sousa-Uva, M., Valensi, P., Wheeler, D. C., Piepoli, M. F., Birkeland, K. I., Adamopoulos, S., Ajjan, R., Avogaro, A., Baigent, C., Brodmann, M., Bueno, H., Ceconi, C., Chioncel, O., Coats, A., Collet, J. -P., Collins, P., Cosyns, B., Di Mario, C., Fisher, M., Fitzsimons, D., Halvorsen, S., Hansen, D., Hoes, A., Holt, R. I. G., Home, P., Katus, H. A., Khunti, K., Komajda, M., Lambrinou, E., Landmesser, U., Lewis, B. S., Linde, C., Lorusso, R., Mach, F., Mueller, C., Neumann, F. -J., Persson, F., Petersen, S. E., Petronio, A. S., Richter, D. J., Rosano, G. M. C., Rossing, P., Ryden, L., Shlyakhto, E., Simpson, I. A., Touyz, R. M., Wijns, W., Wilhelm, M., Williams, B., Windecker, S., Dean, V., Gale, C. P., Hindricks, G., Iung, B., Leclercq, C., Merkely, B., Zelveian, P. H., Scherr, D., Jahangirov, T., Lazareva, I., Shivalkar, B., Naser, N., Gruev, I., Milicic, D., Petrou, P. M., Linhart, A., Hildebrandt, P., Hasan-Ali, H., Marandi, T., Lehto, S., Mansourati, J., Kurashvili, R., Siasos, G., Lengyel, C., Thrainsdottir, I. S., Aronson, D., Di Lenarda, A., Raissova, A., Ibrahimi, P., Abilova, S., Trusinskis, K., Saade, G., Benlamin, H., Petrulioniene, Z., Banu, C., Magri, C. J., David, L., Boskovic, A., Alami, M., Liem, A. H., Bosevski, M., Svingen, G. F. T., Janion, M., Gavina, C., Vinereanu, D., Nedogoda, S., Mancini, T., Ilic, M. D., Fabryova, L., Fras, Z., Jimenez-Navarro, M. F., Norhammar, A., Lehmann, R., Mourali, M. S., Ural, D., Nesukay, E., Chowdhury, T. A., Clinical sciences, Cardio-vascular diseases, Cardiology, Human Physiology and Special Physiology of Physical Education, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Zurich, and Cosentino, Francesco

Subjects
Settore MED/09 - Medicina Interna, Epidemiology, [SDV]Life Sciences [q-bio], 10265 Clinic for Endocrinology and Diabetology, Psychological intervention, Disease, Impaired glucose tolerance, Diabetes mellitus, Health care, risk factors, Guidelines, cardiovascular diseases, cardiovascular risk assessment, diabetes mellitus, epidemiology, impaired glucose tolerance, patient management, patient-centred care, pharmacological treatment, prevention, revascularization, Prediabetes, ComputingMilieux_MISCELLANEOUS, Societies, Medical, ddc:616, Cardiovascular risk assessment, 3. Good health, Europe, Cardiovascular diseases, Pre diabetes, Practice Guidelines as Topic, Cardiology and Cardiovascular Medicine, Pharmacological treatment, medicine.medical_specialty, Patient management, Patient-centred care, Prevention, Revascularization, Risk factors, Settore BIO/14 - FARMACOLOGIA, Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, Prediabetic State, medicine, Humans, business.industry, medicine.disease, Diabetes Mellitus, Type 2, Family medicine, business
Abstract

This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.

Published
2020

258. Standardising definitions for the pre-eclampsia core outcome set: A consensus development study.

Author

Donald F., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero J.A., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Smith Conk A., Soward D., Stepan H., Stroumpoulis K., Surendran A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., Vaughan D.J.A., Vinturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Zermansky A.G., Mol B., Duffy J.M.N., Cairns A.E., Magee L.A., von Dadelszen P., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Lucas D.N., Stark M., Thangaratinam S., Wilson M.J., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., Adamson C.C.D., Akadri A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Beebeejaun Y., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Broughton Pipkin F., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Gbinigie O.A., Gerval M.-O., Ghosh S.K., Gingel L.J., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., Hallman M., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., Homer C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mills D.J., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley J., Mooij R., Moore E.L., Donald F., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero J.A., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Smith Conk A., Soward D., Stepan H., Stroumpoulis K., Surendran A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., Vaughan D.J.A., Vinturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Zermansky A.G., Mol B., Duffy J.M.N., Cairns A.E., Magee L.A., von Dadelszen P., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Lucas D.N., Stark M., Thangaratinam S., Wilson M.J., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., Adamson C.C.D., Akadri A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Beebeejaun Y., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Broughton Pipkin F., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Gbinigie O.A., Gerval M.-O., Ghosh S.K., Gingel L.J., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., Hallman M., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., Homer C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mills D.J., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley J., Mooij R., and Moore E.L.

Abstract

Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Result(s): Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusion(s): Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.Copyright © 2020 International Society for the Study of Hypertension in Pregnancy

Published
2020

259. Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID-19

Author

Yeo, KT, Oei, JL, De Luca, D, Schmolzer, GM, Guaran, R, Palasanthiran, P, Kumar, K, Buonocore, G, Cheong, J, Owen, LS, Kusuda, S, James, J, Lim, G, Sharma, A, Uthaya, S, Gale, C, Whittaker, E, Battersby, C, Modi, N, Norman, M, Naver, L, Giannoni, E, Diambomba, Y, Shah, PS, Gagliardi, L, Harrison, M, Pillay, S, Alburaey, A, Yuan, Y, Zhang, H, Yeo, KT, Oei, JL, De Luca, D, Schmolzer, GM, Guaran, R, Palasanthiran, P, Kumar, K, Buonocore, G, Cheong, J, Owen, LS, Kusuda, S, James, J, Lim, G, Sharma, A, Uthaya, S, Gale, C, Whittaker, E, Battersby, C, Modi, N, Norman, M, Naver, L, Giannoni, E, Diambomba, Y, Shah, PS, Gagliardi, L, Harrison, M, Pillay, S, Alburaey, A, Yuan, Y, and Zhang, H

Abstract

AIM: This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic. METHODS: A systematic search and review identified 20 guidelines and recommendations that had been published by May 25, 2020. We analysed documents from 17 countries: Australia, Brazil, Canada, China, France, India, Italy, Japan, Saudi Arabia, Singapore, South Africa, South Korea, Spain, Sweden, Switzerland, the UK and the United States. RESULTS: The documents were based on expert consensus with limited evidence and were of variable, low methodological rigour. Most did not provide recommendations for delivery methods or managing symptomatic infants. None provided recommendations for post-discharge assimilation of potentially infected infants into the community. The majority encouraged keeping mothers and infants together, subject to infection control measures, but one-third recommended separation. Although breastfeeding or using breastmilk was widely encouraged, two countries specifically prohibited this. CONCLUSION: The guidelines and recommendations for managing infants affected by COVID-19 were of low, variable quality and may be unsustainable. It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. Practice guidelines should emphasise the extent of uncertainty and clearly define gaps in the evidence.

Published
2020

260. A core outcome set for pre-eclampsia research:an international consensus development study

Author

Duffy, J. M.N., Cairns, A. E., Richards-Doran, D., van 't Hooft, J., Gale, C., Brown, M., Chappell, L. C., Grobman, W. A., Fitzpatrick, R., Karumanchi, S. A., Khalil, A., Lucas, D. N., Magee, L. A., Mol, B. W., Stark, M., Thangaratinam, S., Wilson, M. J., von Dadelszen, P., Williamson, P. R., Ziebland, S., McManus, R. J., Abalos, Edgardo J., DA, Christine C.D., AkaDr, Adebayo A., Akturk, Zekeriya, Allegaert, Karel, Angel-Müller, Edith, Antretter, Jessica, Ashdown, Helen F., Audibert, Francois, Auger, Nathalie, Aygun, Canan, Babic, Inas, Bagga, Rashmi, Baker, Judith M., Bhakta, Pradipta, Bhandari, Vineet, Bhattacharya, Sohinee, Blanker, Marco H., Bloomfield, Frank H., Bof, Anna, Brennan, Siobhan M., Broekhuijsen, Kim, Pipkin, Emeritus Fiona Broughton, Browne, Joyce L., Browning, Roger M., Bull, Jameson W., Butt, Amina, Button, Dena, Van Oostwaard, Miriam F., Duffy, J. M.N., Cairns, A. E., Richards-Doran, D., van 't Hooft, J., Gale, C., Brown, M., Chappell, L. C., Grobman, W. A., Fitzpatrick, R., Karumanchi, S. A., Khalil, A., Lucas, D. N., Magee, L. A., Mol, B. W., Stark, M., Thangaratinam, S., Wilson, M. J., von Dadelszen, P., Williamson, P. R., Ziebland, S., McManus, R. J., Abalos, Edgardo J., DA, Christine C.D., AkaDr, Adebayo A., Akturk, Zekeriya, Allegaert, Karel, Angel-Müller, Edith, Antretter, Jessica, Ashdown, Helen F., Audibert, Francois, Auger, Nathalie, Aygun, Canan, Babic, Inas, Bagga, Rashmi, Baker, Judith M., Bhakta, Pradipta, Bhandari, Vineet, Bhattacharya, Sohinee, Blanker, Marco H., Bloomfield, Frank H., Bof, Anna, Brennan, Siobhan M., Broekhuijsen, Kim, Pipkin, Emeritus Fiona Broughton, Browne, Joyce L., Browning, Roger M., Bull, Jameson W., Butt, Amina, Button, Dena, and Van Oostwaard, Miriam F.

Abstract

Objective: To develop a core outcome set for pre-eclampsia. Design: Consensus development study. Setting: International. Population: Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Methods: Modified Delphi method and Modified Nominal Group Technique. Results: A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. Conclusions: The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. Tweetable abstract: 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].

Published
2020

261. Standardising definitions for the pre-eclampsia core outcome set: A consensus development study.

Author

Duffy, JMN, Cairns, AE, Magee, LA, von Dadelszen, P, van 't Hooft, J, Gale, C, Brown, M, Chappell, LC, Grobman, WA, Fitzpatrick, R, Karumanchi, SA, Lucas, DN, Mol, B, Stark, M, Thangaratinam, S, Wilson, MJ, Williamson, PR, Ziebland, S, McManus, RJ, International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE), Duffy, JMN, Cairns, AE, Magee, LA, von Dadelszen, P, van 't Hooft, J, Gale, C, Brown, M, Chappell, LC, Grobman, WA, Fitzpatrick, R, Karumanchi, SA, Lucas, DN, Mol, B, Stark, M, Thangaratinam, S, Wilson, MJ, Williamson, PR, Ziebland, S, McManus, RJ, and International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE)

Abstract

OBJECTIVES: To develop consensus definitions for the core outcome set for pre-eclampsia. STUDY DESIGN: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. RESULTS: Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. CONCLUSIONS: Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.

Published
2020

263. A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence

Author

Hill, W. D., Marioni, R. E., Maghzian, O., Ritchie, S. J., Hagenaars, S. P., McIntosh, A. M., Gale, C. R., Davies, G., and Deary, I. J.

Subjects
Data Analysis, Male, Multifactorial Inheritance, Neurogenesis, Intelligence, Nerve Fibers, Myelinated, Polymorphism, Single Nucleotide, Cognition, Genetic Loci, Humans, Female, Genetic Predisposition to Disease, Immediate Communication, Genome-Wide Association Study
Abstract

Intelligence, or general cognitive function, is phenotypically and genetically correlated with many traits, including a wide range of physical, and mental health variables. Education is strongly genetically correlated with intelligence (rg = 0.70). We used these findings as foundations for our use of a novel approach—multi-trait analysis of genome-wide association studies (MTAG; Turley et al. 2017)—to combine two large genome-wide association studies (GWASs) of education and intelligence, increasing statistical power and resulting in the largest GWAS of intelligence yet reported. Our study had four goals: first, to facilitate the discovery of new genetic loci associated with intelligence; second, to add to our understanding of the biology of intelligence differences; third, to examine whether combining genetically correlated traits in this way produces results consistent with the primary phenotype of intelligence; and, finally, to test how well this new meta-analytic data sample on intelligence predicts phenotypic intelligence in an independent sample. By combining datasets using MTAG, our functional sample size increased from 199,242 participants to 248,482. We found 187 independent loci associated with intelligence, implicating 538 genes, using both SNP-based and gene-based GWAS. We found evidence that neurogenesis and myelination—as well as genes expressed in the synapse, and those involved in the regulation of the nervous system—may explain some of the biological differences in intelligence. The results of our combined analysis demonstrated the same pattern of genetic correlations as those from previous GWASs of intelligence, providing support for the meta-analysis of these genetically-related phenotypes.

Published
2018

268. JETSCAPE Collaboration

Author

Angerami, A., primary, Bass, S.A., additional, Cao, S., additional, Chen, Y., additional, Coleman, J., additional, Cunqueiro, L., additional, Dai, T., additional, Du, L., additional, Ehlers, R., additional, Elfner, H., additional, Everett, D., additional, Fan, W., additional, Fries, R., additional, Gale, C., additional, He, Y., additional, Heffernan, M., additional, Heinz, U., additional, Jacak, B.V., additional, Jacobs, P.M., additional, Jeon, S., additional, Kauder, K., additional, Ke, W., additional, Khalaj, E., additional, Kordell, M., additional, Kumar, A., additional, Luo, T., additional, Luzum, M., additional, Majumder, A., additional, McNelis, M., additional, Mulligan, J., additional, Nattrass, C., additional, Oliinychenko, D., additional, Pablos, D., additional, Pang, L.G., additional, Park, C., additional, Paquet, J.-F., additional, Putschke, J.H., additional, Roland, G., additional, Schenke, B., additional, Schwiebert, L., additional, Shen, C., additional, Silva, A., additional, Sirimanna, C., additional, Soltz, R.A., additional, Tachibana, Y., additional, Vujanovic, G., additional, Wang, X.-N., additional, Wolpert, R.L., additional, Xu, Y., additional, and Yang, Z., additional

Published
2021
Full Text
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271. It's the Heat.

Author

Blackmer, Gale C.

Subjects
ATMOSPHERIC temperature, CLIMATE change, CARBON sequestration
Published
2024

289. The JETSCAPE framework: p+p results

Author

Kumar, A., Tachibana, Y., Pablos, D., Sirimanna, C., Fries, R. J., Angerami, A., Bass, S. A., Cao, S., Chen, Y., Coleman, J., Cunqueiro, L., Dai, T., Du, L., Elfner, H., Everett, D., Fan, W., Gale, C., He, Y., Heinz, U., Jacak, B. V., Jacobs, P. M., Jeon, 15 S., Kauder, K., Ke, W., Khalaj, E., Kordell, M., Luo, T., Majumder, A., McNelis, M., Mulligan, J., Nattrass, C., Oliinychenko, D., Pang, L. -G., Park, C., Paquet, J. -F., Putschke, J. H., Roland, G., Schenke, B., Schwiebert, L., Shen, C., Soltz, R. A., Vujanovic, G., Wang, X. -N., Wolpert, R. L., Xu, Y., and Yang, Z.

Subjects
Nuclear Theory (nucl-th), High Energy Physics - Experiment (hep-ex), Nuclear Theory, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment, High Energy Physics - Experiment
Abstract

The JETSCAPE framework is a modular and versatile Monte Carlo software package for the simulation of high energy nuclear collisions. In this work we present a new tune of JETSCAPE, called PP19, and validate it by comparison to jet-based measurements in $p+p$ collisions, including inclusive single jet cross sections, jet shape observables, fragmentation functions, charged hadron cross sections, and dijet mass cross sections. These observables in $p+p$ collisions provide the baseline for their counterparts in nuclear collisions. Quantifying the level of agreement of JETSCAPE results with $p+p$ data is thus necessary for meaningful applications of JETSCAPE to A+A collisions. The calculations use the JETSCAPE PP19 tune, defined in this paper, based on version 1.0 of the JETSCAPE framework. For the observables discussed in this work calculations using JETSCAPE PP19 agree with data over a wide range of collision energies at a level comparable to standard Monte Carlo codes. These results demonstrate the physics capabilities of the JETSCAPE framework and provide benchmarks for JETSCAPE users., 23 pages, 23 figures; v1.1: minor bug fixes in author information

Published
2019

292. Impact of managed clinical networks on NHS specialist neonatal services in England: population based study

Author

Gale, C, Santhakumaran, S, Nagarajan, S, Statnikov, Y, Modi, N, Neonatal Data Analysis Unit and the Medicines for Neonates Investigator Group, Petrou, S, and Petrou, S

Subjects
medicine.medical_specialty, Pediatrics, business.industry, Research, Child Health, MEDLINE, Gestational age, General Medicine, Odds ratio, Confidence interval, Neonatal Health, Intensive care, Emergency medicine, medicine, Neonatal and Paediatric Intensive Care, Gestation, Observational study, EPOCH (chemotherapy), business
Abstract

Objective To assess the impact of reorganisation of neonatal specialist care services in England after a UK Department of Health report in 2003. Design A population-wide observational comparison of outcomes over two epochs, before and after the establishment of managed clinical neonatal networks. Setting Epoch one: 294 maternity and neonatal units in England, Wales, and Northern Ireland, 1 September 1998 to 31 August 2000, as reported by the Confidential Enquiry into Stillbirths and Sudden Deaths in Infancy Project 27/28. Epoch two: 146 neonatal units in England contributing data to the National Neonatal Research Database at the Neonatal Data Analysis Unit, 1 January 2009 to 31 December 2010. Participants Babies born at a gestational age of 27+0-28+6 (weeks+days): 3522 live births in epoch one; 2919 babies admitted to a neonatal unit within 28 days of birth in epoch two. Intervention The national reorganisation of neonatal services into managed clinical networks. Main outcome measures The proportion of babies born at hospitals providing the highest volume of neonatal specialist care (≥2000 neonatal intensive care days annually), having an acute transfer (within the first 24 hours after birth) and/or a late transfer (between 24 hours and 28 days after birth) to another hospital, assessed by change in distribution of transfer category (“none,” “acute,” “late”), and babies from multiple births separated by transfer. For acute transfers in epoch two, the level of specialist neonatal care provided at the destination hospital (British Association of Perinatal Medicine criteria). Results After reorganisation, there were increases in the proportions of babies born at 27-28 weeks’ gestation in hospitals providing the highest volume of neonatal specialist care (18% (631/3495) v 49% (1325/2724); odds ratio 4.30, 95% confidence interval 3.83 to 4.82; P Conclusions There is evidence of some improvement in the delivery of neonatal specialist care after reorganisation. The increase in acute transfers in epoch two, in conjunction with the high proportion transferred to a neonatal unit providing an equivalent or lower level of specialist care, and the continued separation of babies from multiple births, are indicative of poor coordination between maternity and neonatal services to facilitate in utero transfer before delivery, and continuing inadequacies in capacity of intensive care cots. Historical data representing epoch one are available only in aggregate form, preventing examination of temporal trends or confounding factors. This limits the extent to which differences between epochs can be attributed to reorganisation and highlights the importance of routine, prospective data collection for evaluation of future health service reorganisations.

Published
2019

293. The ESC ACCA EAPCI EORP acute coronary syndrome ST-elevation myocardial infarction registry

Author

Zeymer, U., Ludman, P., Danchin, N., Kala, P., Maggioni, A. P., Weidinger, F, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Franz, Weidinger, Uwe, Zeymer, Nicolas, Danchin, Peter, Ludman, Peter, Sinnaeve, Petr, Kala, Roberto, Ferrari, Maggioni, Aldo P., Artan, Goda, Parounak, Zelveian, Kiril, Karamfilov, Zuzana, Motovska, Bent, Raungaard, Toomas, Marandi, Sameh Mohamed Shaheen, Rosa-Maria, Lidon, Pasi Paavo Karjalainen, Zviad, Kereselidze, Dimitrios, Alexopoulos, David, Becker, Martin, Quinn, Zaza, Iakobishvili, Hasan, Al-Farhan, Masoumeh, Sadeghi, Roberto, Caporale, Francesco, Romeo, Erkin, Mirrakhimov, Pranas, Serpytis, Andrejs, Erglis, Sasko, Kedev, Matthew Mercieca Balbi, Alice May Moore, Dariusz, Dudek, Jacek, Legutko, Jorge, Mimoso, Gabriel, Tatu-Chitoiu, Sinisa, Stojkovic, Evgeny, Shlyakhto, Khalid, F AlHabib, Matjaz, Bunc, Martin, Studencan, Mohamed Sami Mourali, Gani, Bajraktari, Marème, Konte, Florian, Larras, Elin Folkesson Lefrancq, Souad, Mekhaldi, Cécile, Laroche, Goda, A, Shuka, N, Pavli, E, Tafaj, E, Gishto, T, Dibra, A, Duka, A, Gjana, A, Kristo, A, Knuti, G, Demiraj, A, Dado, E, Hasimi, E, Simoni, L, Siqeca, M, Sisakian, H, Hayrapetyan, H, Markosyan, S, Galustyan, L, Arustamyan, N, Kzhdryan, H, Pepoyan, S, Zirkik, A, D Von Lewinski, Paetzold, S, Kienzl, I, Matyas, K, Neunteufl, T, Nikfardjam, M, Neuhold, U, Mihalcz, A, Glaser, F, Steinwender, C, Reiter, C, Grund, M, Hrncic, D, Hoppe, U, Hammerer, M, Hinterbuchner, L, Hengstenberg, C, G Delle Karth, Lang, I, Winkler, W, Hasun, M, Kastner, J, Havel, C, Derntl, M, Oberegger, G, Hajos, J, Adlbrecht, C, Publig, T, M-C, Leitgeb, Wilfing, R, Jirak, P, C-Y, Ho, Puskas, L, Schrutka, L, Spinar, J, Parenica, J, Hlinomaz, O, Fendrychova, V, Semenka, J, Sikora, J, Sitar, J, Groch, L, Rezek, M, Novak, M, Kramarikova, P, Stasek, J, Dusek, J, Zdrahal, P, Polasek, R, Karasek, J, Seiner, J, Sukova, N, Varvarovsky, I, Lazarák, T, Novotny, V, Matejka, J, Rokyta, R, Volovar, S, Belohlavek, J, Motovska, Z, Siranec, M, Kamenik, M, Kralik, R, Raungaard, B, Ravkilde, J, E Jensen, S, Villadsen, A, Villefrance, K, C Schmidt Skov, Maeng, M, Moeller, K, Hasan-Ali, H, A Ahmed, T, Hassan, M, Elguind, A, M Farouk Ismail, A Ibrahim Abd El-Aal, A El-sayed Gaafar, H Magdy Hassan, M Ahmed Shafie, M Nabil El-khouly, Bendary, A, Darwish, M, Ahmed, Y, Amin, O, Abdelhakim, A, Abosaif, K, Kandil, H, M A, G Galal, E El Hefny, E, M El Sayed, Aly, K, Mokarrab, M, Osman, M, Abdelhamid, M, Mantawy, S, R Ali, M, D Kaky, S, A Khalil, V, M E, A Saraya, Talaat, A, Nabil, M, M Mounir, W, Aransa, K. Mahmoud A., Kazamel, G, Anwar, S, Al-Habbaa, A, M Abd el Monem, Ismael, A, Amin Abu-Sheaishaa, M., M Abd Rabou, M, T M, A Hammouda, Moaaz, M, Elkhashab, K, Ragab, T, Rashwan, A, Rmdan, A, Abdelrazek, G, Ebeid, H, H Soliman Ghareeb, Farag, N, Zaki, M, Seleem, M, Torki, A, Youssef, M, A AlLah Nasser, N, Rafaat, A, Selim, H, M Makram, M, Khayyal, M, Malasi, K, Madkou, A, Kolib, M, Alkady, H, Nagah, A, Yossef, M, Wafa, A, Mahfouz, E, Faheem, G, M Magdy Moris, Ragab, A, Ghazal, M, Mabrouk, A, El-Masry, M, Naseem, M, Samir, S, Marandi, T, Reinmets, J, Allvee, M, Saar, A, Ainla, T, Vaide, A, Kisseljova, M, Pakosta, U, Eha, J, Lotamois, K, Sia, J, Myllymaki, J, Pinola, T, P Karjalainen, P, Paana, P, Mikkelsson, J, Ampio, M, Tsivilasvili, J, Zurab, P, Kereselidze, Z, Agladze, R, Melia, A, Gogoberidze, D, Khubua, N, Totladze, L, Metreveli, I, Chikovani, A, Eitel, I, Pöss, J, Werner, M, Constantz, A, Ahrens, C, Tolksdorf, H, Klinger, S, Sack, S, Heer, T, Lekakis, J, Kanakakis, I, Xenogiannis, I, Ermidou, K, Makris, N, Ntalianis, A, Katsaros, F, Revi, E, Kafkala, K, Mihelakis, E, Diakakis, G, Grammatikopoulos, K, Voutsinos, D, Alexopoulos, D, Xanthopoulou, I, Mplani, V, Foussas, S, Papakonstantinou, N, Patsourakos, N, Dimopoulos, A, Derventzis, A, Athanasiou, K, P Vassilikos, V, Papadopoulos, C, Tzikas, S, Vogiatzis, I, Datsios, A, Galitsianos, I, Koutsampasopoulos, K, Grigoriadis, S, Douras, A, Baka, N, Spathis, S, Kyrlidis, T, Hatzinikolaou, H, G Kiss, R, Becker, D, Nowotta, F, Tóth, K, Szabó, S, Lakatos, C, Jambrik, Z, Ruzsa, J, Ruzsa, Z, Róna, S, Toth, J, A Vargane Kosik, K S, B Toth, G Nagy, G, Ondrejkó, Z, Körömi, Z, Botos, B, Pourmoghadas, M, Salehi, A, Massoumi, G, Sadeghi, M, Soleimani, A, Sarrafzadegan, N, Roohafza, H, Azarm, M, Mirmohammadsadeghi, A, Rajabi, D, Rahmani, Y, Siabani, S, Najafi, F, Hamzeh, B, Karim, H, Siabani, H, Saleh, N, Charehjoo, H, Zamzam, L, Al-Temimi, T, Al-Farhan, H, Al-Yassin, A, Mohammad, A, Ridha, A, Al-Saedi, G, Atabi, N, Sabbar, O, Mahmood, S, Dakhil, Z, F Yaseen, I, Almyahi, M, Alkenzawi, H, Alkinani, T, Alyacopy, A, Kearney, P, Twomey, K, Iakobishvili, Z, Shlomo, N, Beigel, R, Caldarola, P, Rutigliano, D, L Sublimi Saponetti, Locuratolo, N, Palumbo, V, Scherillo, M, Formigli, D, Canova, P, Musumeci, G, Roncali, F, Metra, M, Lombardi, C, Visco, E, Rossi, L, Meloni, L, Montisci, R, Pippia, V, F Marchetti, M, Congia, M, Cacace, C, Luca, G, Boscarelli, G, Indolfi, C, Ambrosio, G, Mongiardo, A, Spaccarotella, C, S De Rosa, Canino, G, Critelli, C, Caporale, R, Chiappetta, D, Battista, F, Gabrielli, D, Marziali, A, Bernabò, P, Navazio, A, Guerri, E, Manca, F, Gobbi, M, Oreto, G, Andò, G, Carerj, S, Saporito, F, Cimmino, M, Rigo, F, Zuin, G, Tuccillo, B, F Scotto di Uccio, L Scotto di Uccio, Lorenzoni, G, Meloni, I, Merella, P, M Polizzi, G, Pino, R, Marzilli, M, Morrone, D, Caravelliorsini, P, Orsini, E, Mosa, S, Piovaccari, G, Santarelli, A, Cavazza, C, Romeo, F, Fedele, F, Mancone, M, Straito, M, Salvi, N, Scarparo, P, Severino, P, Razzini, C, Massaro, G, Cinque, A, Gaudio, C, Barillà, F, Torromeo, C, Porco, L, Mei, M, Lorio, R, Nassiacos, D, Barco, B, Sinagra, G, Falco, L, Priolo, L, Perkan, A, Strana, M, Bajraktari, G, Percuku, L, Berisha, G, Mziu, B, Beishenkulov, M, Abdurashidova, T, Toktosunova, A, Kaliev, K, Serpytis, P, Serpytis, R, Butkute, E, Lizaitis, M, Broslavskyte, M, G Xuereb, R, M Moore, A, M Mercieca Balbi, Paris, E, Buttigieg, L, Musial, W, Dobrzycki, S, Dubicki, A, Kazimierczyk, E, Tycinska, A, Wojakowski, W, Kalanska-Lukasik, B, Ochala, A, Wanha, W, Dworowy, S, Sielski, J, Janion, M, Janion-Sadowska, A, Dudek, D, Wojtasik-Bakalarz, J, Bryniarski, L, Z Peruga, J, Jonczyk, M, Jankowski, L, Klecha, A, Legutko, J, Michalowska, J, Brzezinski, M, Kozmik, T, Kowalczyk, T, Adamczuk, J, Maliszewski, M, Kuziemka, P, Plaza, P, Jaros, A, Pawelec, A, Sledz, J, Bartus, S, Zmuda, W, Bogusz, M, Wisnicki, M, Szastak, G, Adamczyk, M, Suska, M, Czunko, P, Opolski, G, Kochman, J, Tomaniak, M, Miernik, S, Paczwa, K, Witkowski, A, P Opolski, M, D Staruch, A, Kalarus, Z, Honisz, G, Mencel, G, Swierad, M, Podolecki, T, Marques, J, Azevedo, P, A Pereira, M, Gaspar, A, Monteiro, S, Goncalves, F, Leite, L, Mimoso, J, Manuel Lopes dos Santos, W., Amado, J, Pereira, D, Silva, B, Caires, G, Neto, M, Rodrigues, R, Correia, A, Freitas, D, Lourenco, A, Ferreira, F, Sousa, F, Portugues, J, Calvo, J, Almeida, F, Alves, M, Silva, A, Caria, R, Seixo, F, Militaru, C, Ionica, E, Tatu-Chitoiu, G, Istratoaie, O, Florescu, M, Lipnitckaia, E, Osipova, O, Konstantinov, S, Bukatov, V, Vinokur, T, Egorova, E, Nefedova, E, Levashov, S, Gorbunova, A, Redkina, M, Karaulovskaya, N, Bijieva, F, Babich, N, Smirnova, O, Filyanin, R, Eseva, S, Kutluev, A, Chlopenova, A, Shtanko, A, Kuppar, E, Shaekhmurzina, E, Ibragimova, M, Mullahmetova, M, Chepisova, M, Kuzminykh, M, Betkaraeva, M, Namitokov, A, Khasanov, N, Baleeva, L, Galeeva, Z, Magamedkerimova, F, Ivantsov, E, Tavlueva, E, Kochergina, A, Sedykh, D, Kosmachova, E, Skibitskiy, V, Porodenko, N, Litovka, K, Ulbasheva, E, Niculina, S, Petrova, M, Harkov, E, Tsybulskaya, N, Lobanova, A, Chernova, A, Kuskaeva, A, Kuskaev, A, Ruda, M, Zateyshchikov, D, Gilarov, M, Konstantinova, E, Koroleva, O, Averkova, A, Zhukova, N, Kalimullin, D, Borovkova, N, Tokareva, A, Buyanova, M, Khaisheva, L, Pirozhenko, T, Novikova, T, Yakovlev, A, Tyurina, T, Lapshin, K, Moroshkina, N, Kiseleva, M, Fedorova, S, Krylova, L, Duplyakov, D, Semenova, Y, Rusina, A, Ryabov, V, Syrkina, A, Demianov, S, Reitblat, O, Artemchuk, A, Efremova, E, Makeeva, E, Menzorov, M, Shutov, A, Klimova, N, Shevchenko, I, Elistratova, O, Kostyuckova, O, Islamov, R, Budyak, V, Ponomareva, E, U Ullah Jan, M Alshehri, A, Sedky, E, Alsihati, Z, Mimish, L, Selem, A, Malik, A, Majeed, O, Altnji, I, Alshehri, M, Aref, A, Alhabib, K, Aldosary, M, Tayel, S, M Abd AlRahman, N Asfina, K, G Abdin Hussein, Butt, M, N Markovic Nikolic, Obradovic, S, Djenic, N, Brajovic, M, Davidovic, A, Romanovic, R, Novakovic, V, Dekleva, M, Spasic, M, Dzudovic, B, Jovic, Z, Cvijanovic, D, Cvijanovic, S, Ivanov, I, Cankovic, M, Jarakovic, M, Kovacevic, M, Trajkovic, M, Mitov, V, Jovic, A, Hudec, M, Gombasky, M, Sumbal, J, Bohm, A, Baranova, E, Kovar, F, Samos, M, Podoba, J, Kurray, P, Obona, T, Remenarikova, A, Kollarik, B, Verebova, D, Kardosova, G, Studencan, M, Alusik, D, Macakova, J, Kozlej, M, Bayes-Genis, A, Sionis, A, C Garcia Garcia, R-M, Lidon, A Duran Cambra, C Labata Salvador, F Rueda Sobella, J Sans Rosello, M Vila Perales, T Oliveras Vila, M Ferrer Massot, Bañeras, J, Lekuona, I, Zugazabeitia, G, Fernandez-Ortiz, A, A Viana Tejedor, Ferrera, C, Alvarez, V, Diaz-Castro, O, M Agra-Bermejo, R, Gonzalez-Cambeiro, C, Gonzalez-Babarro, E, J Domingo-Del Valle, Royuela, N, Burgos, V, Canteli, A, Castrillo, C, Cobo, M, Ruiz, M, Abu-Assi, E, M Garcia Acuna, J, U., Zeymer, P., Ludman, N., Danchin, P., Kala, A. P., Maggioni, F., Weidinger, STEMI Investigators, Ac, and Spaccarotella, C.

Subjects
Registrie, medicine.medical_specialty, Acute coronary syndrome, Registry, medicine.medical_treatment, Cardiology, Reperfusion therapy, Retrospective Studie, Medical, medicine, Humans, cardiovascular diseases, Myocardial infarction, Registries, Disease management (health), Acute Coronary Syndrome, Societies, Medical, Quality of Health Care, Retrospective Studies, Acca, biology, business.industry, Health Policy, Primary percutaneous coronary intervention, Percutaneous coronary intervention, Disease Management, Retrospective cohort study, medicine.disease, biology.organism_classification, primary percutaneous coronary intervention, registry, reperfusion therapy, ST-elevation myocardial infarction, Cardiac surgery, Europe, surgical procedures, operative, Emergency medicine, ST Elevation Myocardial Infarction, Societies, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims The Acute Cardiac Care Association (ACCA)–European Association of Percutaneous Coronary Intervention (EAPCI) Registry on ST-elevation myocardial infarction (STEMI) of the EurObservational programme (EORP) of the European Society of Cardiology (ESC) registry aimed to determine the current state of the use of reperfusion therapy in ESC member and ESC affiliated countries and the adherence to ESC STEMI guidelines in patients with STEMI. Methods and results Between 1 January 2015 and 31 March 2018, a total of 11 462 patients admitted with an initial diagnosis of STEMI according to the 2012 ESC STEMI guidelines were enrolled. Individual patient data were collected across 196 centres and 29 countries. Among the centres, there were 136 percutaneous coronary intervention centres and 91 with cardiac surgery on-site. The majority of centres (129/196) were part of a STEMI network. The main objective of this study was to describe the demographic, clinical, and angiographic characteristics of patients with STEMI. Other objectives include to assess management patterns and in particular the current use of reperfusion therapies and to evaluate how recommendations of most recent STEMI European guidelines regarding reperfusion therapies and adjunctive pharmacological and non-pharmacological treatments are adopted in clinical practice and how their application can impact on patients’ outcomes. Patients will be followed for 1 year after admission. Conclusion The ESC ACCA-EAPCI EORP ACS STEMI registry is an international registry of care and outcomes of patients hospitalized with STEMI. It will provide insights into the contemporary patient profile, management patterns, and 1-year outcome of patients with STEMI.

Published
2019

294. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., TRAMPUSH, J. W., LUCIANO, M., HILL, W. D., HAGENAARS, S. P., RITCHIE, S. J., MARIONI, R. E., FAWNS-RITCHIE, C., LIEWALD, D. C. M., OKELY, J. A., AHOLA-OLLI, A. V., BARNES, C. L. K., Bertram, L., BIS, J. C., BURDICK, K. E., CHRISTOFOROU, A., DEROSSE, P., Djurovic, S., ESPESETH, T., GIAKOUMAKI, S., GIDDALURU, S., GUSTAVSON, D. E., Hayward, C., Hofer, E., KARLSSON, R., KNOWLES, E., Lahti, J., Leber, M., MATHER, K. A., Melle, I., Morris, D., OLDMEADOW, C., PALVIAINEN, T., PAYTON, A., PAZOKI, R., PETROVIC, K., Reynolds, C. A., SARGURUPREMRAJ, M., Scholz, M., Smith, J. A., SMITH, A. V., TERZIKHAN, N., THALAMUTHU, A., TROMPET, S., VAN DER LEE, S. J., WARE, E. B., WINDHAM, B. G., WRIGHT, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., ANDREASSEN, O. A., ARMSTRONG, N. J., ASSAREH, A. A., ATTIA, J. R., ATTIX, D., AVRAMOPOULOS, D., BENNETT, D. A., BOHMER, A. C., BOYLE, P. A., BRODATY, H., Campbell, H., CANNON, T. D., CIRULLI, E. T., CONGDON, E., CONLEY, E. D., CORLEY, J., COX, S. R., DALE, A. M., DEHGHAN, A., Dick, D., Dickinson, D., ERIKSSON, J. G., EVANGELOU, E., FAUL, J. D., Ford, I., FREIMER, N. A., Gao, H., Giegling, I., GILLESPIE, N. A., GORDON, S. D., GOTTESMAN, R. F., GRISWOLD, M. E., GUDNASON, V., HARRIS, T. B., HARTMANN, A. M., Hatzimanolis, A., Heiss, G., HOLLIDAY, E. G., Joshi, P. K., KAHONEN, M., KARDIA, S. L. R., KARLSSON, I., KLEINEIDAM, L., KNOPMAN, D. S., KOCHAN, N. A., Konte, B., KWOK, J. B., LE HELLARD, S., Lee, T., LEHTIMAKI, T., Li, S. C., Lill, C. M., Liu, T., KOINI, M., London, E., LONGSTRETH, W. T., Jr., LOPEZ, O. L., LOUKOLA, A., LUCK, T., LUNDERVOLD, A. J., LUNDQUIST, A., LYYTIKAINEN, L. P., Martin, N. G., MONTGOMERY, G. W., MURRAY, A. D., NEED, A. C., NOORDAM, R., Nyberg, L., OLLIER, W., PAPENBERG, G., PATTIE, A., POLASEK, O., POLDRACK, R. A., PSATY, B. M., REPPERMUND, S., RIEDEL-HELLER, S. G., ROSE, R. J., ROTTER, J. I., ROUSSOS, P., ROVIO, S. P., SABA, Y., SABB, F. W., SACHDEV, P. S., SATIZABAL, C. L., Schmid, M., Scott, R. J., SCULT, M. A., SIMINO, J., SLAGBOOM, P. E., SMYRNIS, N., Soumare, A., Stefanis, N. C., STOTT, D. J., STRAUB, R. E., SUNDET, K., Taylor, A. M., TAYLOR, K. D., TZOULAKI, I., Tzourio, C., Uitterlinden, A., Vitart, V., VOINESKOS, A. N., Kaprio, J., Wagner, M., Wagner, H., WEINHOLD, L., WEN, K. H., WIDEN, E., Yang, Q., Zhao, W., ADAMS, H. H. H., ARKING, D. E., Bilder, R. M., BITSIOS, P., BOERWINKLE, E., CHIBA-FALEK, O., Corvin, A., DE JAGER, P. L., Debette, S., Donohoe, G., Elliott, P., FITZPATRICK, A. L., Gill, M., GLAHN, D. C., HAGG, S., HANSELL, N. K., HARIRI, A. R., Ikram, M. A., JUKEMA, J. W., VUOKSIMAA, E., KELLER, M. C., KREMEN, W. S., LAUNER, L., LINDENBERGER, U., Palotie, A., PEDERSEN, N. L., PENDLETON, N., PORTEOUS, D. J., RAIKKONEN, K., RAITAKARI, O. T., Ramirez, A., REINVANG, I., RUDAN, I., DAN, Rujescu, Schmidt, R., Schmidt, H., SCHOFIELD, P. W., STARR, J. M., STEEN, V. M., TROLLOR, J. N., TURNER, S. T., VAN DUIJN, C. M., VILLRINGER, A., WEINBERGER, D. R., WEIR, D. R., WILSON, J. F., Malhotra, A., MCINTOSH, A. M., GALE, C. R., SESHADRI, S., MOSLEY, T. H., Jr., BRESSLER, J., Lencz, T., DEARY, I. J., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
VINTAGE, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, HEALTHY, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.

Published
2019

295. Genetic analysis identifies molecular systems and biological pathways associated with household income

Author

David Hill, W, Davies, N, Ritchie, S, Skene, N, Bryois, J, Bell, S, Angelantonio, ED, Roberts, D, Xueyi, S, Davies, G, Liewald, DCM, Porteous, D, Hayward, C, Butterworth, A, McIntosh, A, Gale, C, and Deary, I

Abstract

Socio-economic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. Previous genome-wide association studies (GWAS) using household income as a marker of SEP have shown that common genetic variants account for 11% of its variation. Here, in a sample of 286,301 participants from UK Biobank, we identified 30 independent genome-wide significant loci, 29 novel, that are associated with household income. Using a recently-developed method to meta-analyze data that leverages power from genetically-correlated traits, we identified an additional 120 income-associated loci. These loci showed clear evidence of functional enrichment, with transcriptional differences identified across multiple cortical tissues, in addition to links with GABAergic and serotonergic neurotransmission. We identified neurogenesis and the components of the synapse as candidate biological systems that are linked with income. By combining our GWAS on income with data from eQTL studies and chromatin interactions, 24 genes were prioritized for follow up, 18 of which were previously associated with cognitive ability. Using Mendelian Randomization, we identified cognitive ability as one of the causal, partly-heritable phenotypes that bridges the gap between molecular genetic inheritance and phenotypic consequence in terms of income differences. Significant differences between genetic correlations indicated that, the genetic variants associated with income are related to better mental health than those linked to educational attainment (another commonly-used marker of SEP). Finally, we were able to predict 2.5% of income differences using genetic data alone in an independent sample. These results are important for understanding the observed socioeconomic inequalities in Great Britain today.

Published
2019

296. Is the association between blood pressure and mortality in older adults different with frailty? A systematic review and meta-analysis

Author

Todd, O, Wilkinson, C, Hale, M, Wong, N, Hall, M, Sheppard, J, McManus, R, Rockwood, K, Young, J, Gale, C, and Clegg, A

Abstract

Objective to investigate whether the association between blood pressure and clinical outcomes is different in older adults with and without frailty, using observational studies. Methods MEDLINE, EMBASE and CINAHL were searched from 1st January 2000 to 13th June 2018. PROSPERO CRD42017081635. We included all observational studies reporting clinical outcomes in older adults with an average age over 65 years living in the community with and without treatment that measured blood pressure and frailty using validated methods. Two independent reviewers evaluated study quality and risk of bias using the ROBANS tool. We used generic inverse variance modelling to pool risks of all-cause mortality adjusted for age and sex. Results nine observational studies involving 21,906 older adults were included, comparing all-cause mortality over a mean of six years. Fixed effects meta-analysis of six studies demonstrated that in people with frailty, there was no mortality difference associated with systolic blood pressure 140 mm Hg (HR 1.02, 95% CI 0.90 to 1.16). In the absence of frailty, systolic blood pressure 140 mm Hg (HR 0.86, 95% CI 0.77 to 0.96). Conclusions evidence from observational studies demonstrates no mortality difference for older people with frailty whose systolic blood pressure is 140 mm Hg. Current evidence fails to capture the complexities of blood pressure measurement, and the association with non-fatal outcomes.

Published
2019

297. Centrality dependence of the direct photon multiplicity in heavy ion collisions

Author

Gale, C., Jeon, S., Mcdonald, S., Jean-François Paquet, and Shen, C.

Subjects
Nuclear Theory (nucl-th), Nuclear Theory, FOS: Physical sciences
Abstract

Measurements indicate that the centrality dependence of the direct photon multiplicity scales approximately with the number of binary nucleon collisions. Importantly, these same measurements suggest that this scaling does not depend on the cutoff used to define the photon multiplicity. In this work we provide a theoretical perspective on these observations. We emphasize the importance of stronger experimental constraints, in particular for the cutoff independence of the centrality scaling. We highlight the importance of revisiting theoretical studies of jet-medium photons and of medium-modified prompt photons to clarify their contribution to the direct photon multiplicity, as well as the magnitude and direction of their momentum anisotropy., Contribution to Hard Probes 2018 proceedings. 4 pages

Published
2019

298. Multi-stage jet evolution through QGP using the JETSCAPE framework: inclusive jets, correlations and leading hadrons

Author

Park, C., Angerami, A., Bass, S. A., Cao, S., Coleman, J., Cunqueiro, L., Dai, T., Du, L., Elfner, H., Everett, D., Fan, W., Fries, R., Gale, C., He, Y., Heinz, U., Jacak, B. V., Jacobs, P. M., Jeon, S., Kauder, K., Ke, W., Khalaj, E., Kordell II, M., Kumar, A., Luo, T., Majumder, A., McNelis, M., Nattrass, C., Oliinychenko, D., Pablos, D., Pang, L. G., Paquet, J. -F., Putschke, J. H., Roland, G., Schenke, B., Schwiebert, L., Shen, C., Sirimanna, C., Soltz, R. A., Tachibana, Y., Vujanovic, G., Wang, X. -N., Wolpert, R. L., Xu, Y., and Yang, Z.

Subjects
Nuclear Theory (nucl-th), High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Nuclear Theory, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The JETSCAPE Collaboration has recently announced the first release of the JETSCAPE package that provides a modular, flexible, and extensible Monte Carlo event generator. This innovative framework makes it possible to perform a comprehensive study of multi-stage high-energy jet evolution in the Quark-Gluon Plasma. In this work, we illustrate the performance of the event generator for different algorithmic approaches to jet energy loss, and reproduce the measurements of several jet and hadron observables as well as correlations between the hard and soft sector. We also carry out direct comparisons between different approaches to energy loss to study their sensitivity to those observables.

Published
2019
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299. Cross-sectional associations between personality traits and device-based measures of step count and sedentary behaviour in older age: the Lothian Birth Cohort 1936

Author

Cukic, I, Gale, C R, Chastin, SFM, Dall, PM, Dontje, Manon, Skelton, DA, Deary, IJ, Cox, S, Coulter, E, Der, G, Fitzsimons, C, Gill, J, Granat, M, Gray, C, Greig, C, Hindle, E, Laird, K, Mead, G, Mutrie, N, Palmer, V, Radakovic, R, Sattar, N, Shaw, R, Starr, J, Stewart, S, Wyke, S, and Public Health

Subjects
Male, Aging, Older age, lcsh:Geriatrics, Cohort Studies, 0302 clinical medicine, Medicine and Health Sciences, SITTING TIME, Medicine, 030212 general & internal medicine, Big Five personality traits, Personality traits, media_common, RISK, CARDIOVASCULAR-DISEASE, Female, Birth cohort, Research Article, Personality, media_common.quotation_subject, Physical activity, Fitness Trackers, Health outcomes, Age and sex, 03 medical and health sciences, Step count, Humans, Device-based measures, activPAL, Exercise, METAANALYSIS, Aged, Sedentary time, business.industry, MORTALITY, 030229 sport sciences, ADULTS, Sedentary behaviour, United Kingdom, lcsh:RC952-954.6, Cross-Sectional Studies, PHYSICAL-ACTIVITY, Scotland, Self Report, Geriatrics and Gerontology, Sedentary Behavior, business, Demography
Abstract

Background While the associations between personality traits and self-reported physical activity are well replicated, few studies have examined the associations between personality and device-based measures of both physical activity and sedentary behaviour. Low levels of physical activity and high levels of sedentary behaviour are known risk factors for poorer health outcomes in older age. Methods We used device-based measures of physical activity and sedentary behaviour recorded over 7 days in 271 79-year-old participants of the Lothian Birth Cohort 1936. Linear regression models were used to assess whether personality traits were cross-sectionally associated with step count, sedentary time, and the number of sit-to-stand transitions. Personality traits were entered one at a time, and all-together, controlling for age and sex in Model 1 and additionally for BMI and limiting long-term illness in Model 2. Results None of the associations between personality traits and measures of physical activity and sedentary behaviours remained significant after controlling for multiple-comparisons using the False Discovery Rate test (all ps > .07). Conclusions We found no evidence that personality traits are associated with device-based measures of physical activity or sedentary behaviour in older age. More studies are needed to replicate and examine the nature of these relationships.

Published
2019

300. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Author

De Backer, Guy Jankowski, Piotr Kotseva, Kornelia and Mirrakhimov, Erkin Reiner, Zeljko Ryden, Lars Tokgozoglu, Lale Wood, David De Bacquer, Dirk Abreu, A. Aguiar, C. and Badariene, J. Bruthans, J. Castro Conde, A. Cifkova, R. and Crowley, J. Davletov, K. De Smedt, D. De Sutter, J. and Deckers, J. W. Dilic, M. Dolzhenko, M. Druais, H. and Dzerve, V. Erglis, A. Fras, Z. Gaita, D. Gotcheva, N. and Grobbee, D. E. Gyberg, V. Ali, H. Hasan Heuschmann, P. and Hoes, A. W. Lalic, N. Lehto, S. Lovic, D. Maggioni, A. P. Mancas, S. Marques-Vidal, P. Mellbin, L. Milicic, D. Oganov, R. Pogosova, N. Stagmo, M. Stoerk, S. and Sundvall, J. Tsioufis, K. Vulic, D. Wood, D. A. and Jennings, C. Adamska, A. Adamska, S. Mellbin, L. and Tuomilehto, J. Schnell, O. Fiorucci, E. Glemot, M. and Larras, F. Missiamenou, V. Maggioni, A. Taylor, C. and Ferreira, T. Lemaitre, K. Raman, L. Sundvall, J. and DeSmedt, D. De Sutter, J. Willems, A. M. De Pauw, M. and Vervaet, P. Bollen, J. Dekimpe, E. Mommen, N. Van Genechten, G. Dendale, P. Bouvier, C. A. Chenu, P. and Huyberechts, D. Persu, A. Dilic, M. Begic, A. Nalbantic, A. Durak Dzubur, A. Hadzibegic, N. Iglica, A. Kapidjic, S. Bico, A. Osmanagic Resic, N. Bajramovic, N. Sabanovic and Zvizdic, F. Vulic, D. Kovacevic-Preradovic, T. and Popovic-Pejicic, S. Djekic, D. Gnjatic, T. Knezevic, T. and Kovacevic-Preradovic, T. Kos, Lj Popovic-Pejicic, S. and Stanetic, B. Topic, G. Gotcheva, N. Georgiev, Borislav and Terziev, A. Vladimirov, G. Angelov, A. Kanazirev, B. and Nikolaeva, S. Tonkova, D. Vetkova, M. Milicic, D. and Bosnic, A. Dubravcic, M. Glavina, M. Mance, M. and Pavasovic, S. Samardzic, J. Batinic, T. Crljenko, K. and Delic-Brkljacic, D. Dula, K. Golubic, K. Klobucar, I. and Kordic, K. Kos, N. Nedic, M. Olujic, D. Sedinic, V. and Blazevic, T. Pasalic, A. Percic, M. Sikic, J. Bruthans, J. Cifkova, R. Hasplova, K. Sulc, P. Wohlfahrt, P. and Mayer, Jr., O. Cvicela, M. Filipovsky, J. Gelzinsky, J. and Hronova, M. Hasan-Ali, H. Bakery, S. Mosad, E. Hamed, H. B. Ibrahim, A. Elsharef, M. A. Kholef, E. F. Shehata, A. and Youssef, M. Elhefny, E. Farid, H. Moustafa, T. M. and Sobieh, M. S. Kabil, H. Abdelmordy, A. Lehto, S. and Kiljander, E. Kiljander, P. Koukkunen, H. Mustonen, J. and Cremer, C. Frantz, S. Haupt, A. Hofmann, U. Ludwig, K. and Melnyk, H. Noutsias, M. Karmann, W. Prondzinsky, R. and Herdeg, C. Hoevelborn, T. Daaboul, A. Geisler, T. and Keller, T. Sauerbrunn, D. Walz-Ayed, M. Ertl, G. Leyh, R. Stoerk, S. Heuschmann, P. Ehlert, T. Klocke, B. and Krapp, J. Ludwig, T. Kaes, J. Starke, C. Ungethuem, K. and Wagner, M. Wiedmann, S. Tsioufis, K. Tolis, P. and Vogiatzi, G. Sanidas, E. Tsakalis, K. Kanakakis, J. and Koutsoukis, A. Vasileiadis, K. Zarifis, J. Karvounis, C. and Crowley, J. Gibson, I. Houlihan, A. Kelly, C. O'Donnell, M. Bennati, M. Cosmi, F. Mariottoni, B. Morganti, M. and Cherubini, A. Di Lenarda, A. Radini, D. Ramani, F. and Francese, M. G. Gulizia, M. M. Pericone, D. Davletov, K. and Aigerim, K. Bekbolat, Z. Amirov, B. Assembekov, B. and Chernokurova, E. Ibragimova, F. Kodasbayev, A. Markova, A. and Asanbaev, A. Toktomamatov, U. Tursunbaev, M. Zakirov, U. and Abilova, S. Arapova, R. Bektasheva, E. Esenbekova, J. and Neronova, K. Asanbaev, A. Baigaziev, K. Toktomamatov, U. and Zakirov, U. Baitova, G. Zheenbekov, T. Erglis, A. and Andrejeva, T. Bajare, I. Kucika, G. Labuce, A. Putane, L. Stabulniece, M. Dzerve, V. Klavins, E. Sime, I. and Badariene, J. Gedvilaite, L. Peciuraite, D. Sileikiene, V. and Skiauteryte, E. Solovjova, S. Sidabraite, R. Briedis, K. and Ceponiene, I. Jurenas, M. Kersulis, J. Martinkute, G. and Vaitiekiene, A. Vasiljevaite, K. Veisaite, R. Plisiene, J. Siurkaite, V. Vaiciulis, Z. Czarnecka, D. Koziel, P. and Podolec, P. Nessler, J. Gomula, P. Mirek-Bryniarska, E. and Bogacki, P. Wisniewski, A. Pajak, A. Wolfshaut-Wolak, R. and Bucko, J. Kaminski, K. Lapinska, M. Paniczko, M. and Raczkowski, A. Sawicka, E. Stachurska, Z. Szpakowicz, M. and Musial, W. Dobrzycki, S. Bychowski, J. Kosior, D. A. and Krzykwa, A. Setny, M. Kosior, D. A. Rak, A. Gasior, Z. and Haberka, M. Gasior, Z. Haberka, M. Szostak-Janiak, K. and Finik, M. Liszka, J. Botelho, A. Cachulo, M. Sousa, J. Pais, A. Aguiar, C. Durazzo, A. Matos, D. and Gouveia, R. Rodrigues, G. Strong, C. Guerreiro, R. and Aguiar, J. Abreu, A. Cruz, M. Daniel, P. Morais, L. and Moreira, R. Rosa, S. Rodrigues, I. Selas, M. Gaita, D. and Mancas, S. Apostu, A. Cosor, O. Gaita, L. Giurgiu, L. Hudrea, C. Maximov, D. Moldovan, B. Mosteoru, S. and Pleava, R. Ionescu, M. Parepa, I. Pogosova, N. and Arutyunov, A. Ausheva, A. Isakova, S. Karpova, A. and Salbieva, A. Sokolova, O. Vasilevsky, A. Pozdnyakov, Y. and Antropova, O. Borisova, L. Osipova, I. Lovic, D. and Aleksic, M. Crnokrak, B. Djokic, J. Hinic, S. Vukasin, T. Zdravkovic, M. Lalic, N. M. Jotic, A. Lalic, K. and Lukic, L. Milicic, T. Macesic, M. Gajovic, J. Stanarcic and Stoiljkovic, M. Djordjevic, D. 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Kultursay, S. Akkoyun H. Kayikcioglu, M. Catakoglu, A. B. and Cengel, A. Kocak, A. A. Agirbasli, M. A. Aciksari, G. and Cekin, M. E. Kaya, E. B. Kocyigit, D. Ongen, Z. and Ozmen, E. Sansoy, V. Kaya, A. Oktay, V. Temizhan, A. and Unal, S. Yakut, I. Kalkan, A. K. Bozkurt, E. Kasapkara, H. A. Dolzhenko, M. Faradzh, C. Hrubyak, L. Konoplianyk, L. Kozhuharyova, N. Lobach, L. Nesukai, V. Nudchenko, O. and Simagina, T. Yakovenko, L. Azarenko, V. Potabashny, V. and Bazylevych, A. Bazylevych, M. Kaminska, K. Panchenko, L. and Shershnyova, O. Ovrakh, T. Serik, S. Kolesnik, T. and Kosova, H. Adamska, A. Adamska, S. Jennings, C. Atkin, A. Hoye P. Fellowes, D. Lindsay, S. Atkinson, C. and Kranilla, C. Vinod, M. Beerachee, Y. Bennett, C. Broome, M. Bwalya, A. Caygill, Lindsay Dinning, L. Gillespie, A. and Goodfellow, R. Guy, J. Idress, T. Mills, C. Morgan, C. Oustance, N. Singh, N. Yare, M. Jagoda, J. M. and Bowyer, H. Christenssen, V. Groves, A. Jan, A. Riaz, A. and Gill, M. Sewell, T. A. Gorog, D. Baker, M. De Sousa, P. Mazenenga, T. Porter, J. Haines, F. Peachey, T. and Taaffe, J. Wells, K. Ripley, D. P. Forward, H. McKie, H. and Pick, S. L. Thomas, H. E. Batin, P. D. Exley, D. and Rank, T. Wright, J. Kardos, A. Sutherland, S. -B. Wren, L. Leeson, P. Barker, D. Moreby, B. Sawyer, J. and Stirrup, J. Brunton, M. Brodison, A. Craig, J. Peters, S. Kaprielian, R. Bucaj, A. Mahay, K. Oblak, M. and Gale, C. Pye, M. McGill, Y. Redfearn, H. Fearnley, M. and EUROASPIRE V Collaborators Writing Comm Sci Steering Executive Comm Coordinating Ctr Diabet Ctr Data Management Ctr Stat Anal Ctr Cent Lab Study Ctr Org Investigators Other

Abstract

Background and aims: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Methods: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. Results: At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. Conclusions: The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.

Published
2019

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