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252. Fine mapping of human HOX gene clusters

Author

M.F. Poupon, Bernard Dutrillaux, Bernard Malfoy, D. Flagiello, C. Cillo, Françoise Apiou, Apiou, F, Flagiello, D, Cillo, Clemente, Malfoy, B, Poupon, Mf, and Dutrillaux, B.

Subjects
Genetics, Chromosomes, Human, Pair 12, DNA, Complementary, medicine.diagnostic_test, Chromosome localization, Genes, Homeobox, Chromosome Mapping, Biology, Gene mapping, Chromosomes, Human, Pair 2, Gene cluster, medicine, Humans, %22">Fish , Lymphocytes, Hox gene, Molecular Biology, Gene, Cells, Cultured, Chromosomes, Human, Pair 7, In Situ Hybridization, Fluorescence, Genetics (clinical), Chromosomes, Human, Pair 17, Fluorescence in situ hybridization
Abstract

The chromosome localization of human HOX gene clusters has been reinvestigated by fluorescence in situ hybridization (FISH). Three loci were precisely localized in 7p15.3 (HOXA@), 17q21.3 (HOXB@) and 12ql3.3 (HOXC@). The localization of HOXD@ was confirmed to 2q31.

Published
1996

255. 1651Role of Metronidazole vs Vancomycin as Initial Therapy in Hospitalized Patients with Mild to Moderate Clostridium difficile Infection (CDI) with NAP1 vs non-NAP1 Disease

Author

Amar Safdar, Michael Phillips, Marco R. Scipione, Justin Siegfried, Yanina Dubrovskaya, John Papadopoulos, Thomas Flagiello, and Donald Chen

Subjects
medicine.medical_specialty, Hospitalized patients, business.industry, Disease, Clostridium difficile, Metronidazole, IDWeek 2014 Abstracts, Infectious Diseases, Oncology, Internal medicine, Poster Abstracts, medicine, Vancomycin, Initial therapy, business, Intensive care medicine, medicine.drug
Published
2014

256. STATUS OF THE VIRGO EXPERIMENT

Author

L. Pinard, F. Le Diberder, R. Morand, P. Lapenna, Maurizio Longo, S. Braccini, François Bondu, M. Morganti, P.T. Manh, C. Bradaschia, Fabrizio Palla, M. Jacquemet, R. Flaminio, M. Yvert, R. Del Fabbro, Zhenyu Zhang, Fabrizio Barone, A. Giazotto, L. Di Fiore, B. Mours, A. Grado, D. Passuello, M. Taubmann, I. Ferrante, M. Barsuglia, G. Torelli, F. Marion, Leopoldo Milano, J-Y. Vinet, J. Kovalik, Luca Gammaitoni, Gianpietro Cagnoli, B. Caron, J.-M. Mackowski, R. De Salvo, V. Brisson, M. Napolitano, M. Davier H. Heitmann, L. Latrach, C. N. Man, F. Fidecaro, Alessandro Giassi, H. B. Pan, F. Ricci, A. Di Virgilio, C. Drezen, Agnes Dominjon, L. Dognin, A. Brillet, L. Massonnet, S. Lami, M. Flagiello, Fabio Marchesoni, P. Hello, J. P. Roger, Ettore Majorana, Salvatore Solimeno, G. Matone, P. Puppo, C. Boccara, G. Losurdo, S. Mancini, D. Babusci, Enrico Calloni, G. Gorini, M. Punturo, V. Loriette, Marco Lops, Rosa Poggiani, M. Bernardini, X. Grave, Y. Acker, P. Gleyzes, P. Rapagnani, L. Holloway, F. Cavalier, G.V. Russo, G. Giordano, C. Mehmel, Stefano Marano, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), VIRGO, B., Caron, A., Dominjon, C., Drezen, R., Flaminio, X., Grave, F., Marion, L., Massonnet, C., Mehmel, R., Morand, B., Mour, M., Yvert, D., Babusci, G., Giordano, G., Matone, J. M., Mackowski, M., Napolitano, L., Pinard, L., Dognin, F., Barone, Calloni, Enrico, L., Di Fiore, M., Flagiello, A., Grado, M., Longo, S., Marano, Milano, Leopoldo, Russo, Guido, Solimeno, Salvatore, Y., Acker, A., Brillet, F., Bondu, V., Brisson, F., Cavalier, M. Davier H., Heitmann, P., Hello, M., Jacquemet, L., Latrach, F., Le Diberder, C. N., Man, P. T., Manh, M., Taubmann, J. Y., Vinet, C., Boccara, Gleyzes, P. h., J. P., Roger, V., Loriette, G., Cagnoli, L., Gammaitoni, J., Kovalik, F., Marchesoni, M., Punturo, M., Barsuglia, M., Bernardini, S., Braccini, C., Bradaschia, R., Del Fabbro, R., De Salvo, A., Di Virgilio, I., Ferrante, F., Fidecaro, A., Giassi, A., Giazotto, G., Gorini, L., Holloway, S., Lami, P., Lapenna, G., Losurdo, S., Mancini, M., Morganti, F., Palla, H. B., Pan, D., Passuello, R., Poggiani, G., Torelli, Z., Zhang, E., Majorana, P., Puppo, P., Rapagnani, F., Ricci, Flores, Sylvie, H., Fang, L., Matone, V., Sannibale, Gleizes, P. h., F., Cleva, M., Davier, H., Heitmann, J. M., Innocent, A., Marraud, G. M., Nguyen, M., Pham Tu, L. E., Holloway, C. X., Hong, A., Lusiani, and Z., Zhou

Subjects
Physics, Nuclear and High Energy Physics, Detection of gravitational waves, Gravitational-wave observatory, Gravitational wave, business.industry, Bandwidth (signal processing), Detector, Astronomy, Michelson interferometer, Atomic and Molecular Physics, and Optics, law.invention, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Detection of gravitational wave, Optics, Interferometry, [PHYS.ASTR.CO] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], law, business, Instrumentation
Abstract

The VIRGO experiment was approved in September 1993. The goal of the French-Italian collaboration is to detect gravitational waves using a 3 km arm-length Michelson interferometer. The construction of this detector, which will be installed in Pisa, is under way. The experiment is planned to take data, in a large bandwidth (10 Hz-10 kHz), at the beginning of the year 2000 with nominal sensitivity close to h = 3 X 10-‘3/&. The motivations, detection principle, main sources of noise and status of the experiment are presented.

Published
1995

265. Complex Relationships Between DNA Methylation Status and Chromosome Compaction and Cohesion

Author

B. Dutrillaux, D. Flagiello, and J. Bernardino-Sgherri

Subjects
Establishment of sister chromatid cohesion, Genetics, medicine.medical_specialty, Cancer cell, DNA methylation, Cytogenetics, medicine, Sister chromatids, Chromosome, Biology, Mitosis, Metaphase, Cell biology
Abstract

Mitotic chromosomes are generally studied on cultured cells. For instance, almost all data collected in human cytogenetics since the early 1960s were obtained from fibroblast, lymphocyte, amniotic and trophoblastic cell cultures. Even for cancer cells, which are spontaneously proliferating, cultures are almost always performed before metaphase harvesting. Consequently, the chromosomes of spontaneously dividing cells are rarely studied. When such studies are successfully performed, chromosomes of “poor quality” are invariably obtained. Indeed, the notion of quality for mitotic chromosomes is purely subjective, the goal of cytogeneticists being the obtention of sharply delineated chromosomes, which can resist to treatments inducing banding or allowing “in situ” hybridization. The “poor quality” of chromosomes from non-cultured cells may have several explanations. It is more difficult to standardize the cytological techniques. Mitotic indexes are generally low, which reduces the choice of mitotic cells. It is also possible that mitotic chromosome structure is different.

Published
2004

268. Helical CT diagnosis of small bowel obstruction in the acute clinical setting

Author

Mariano Scaglione, Stefania Romano, Ferdinando Flagiello, Roberto Farina, Ciro Acampora, Luigia Romano, and Fabio Pinto

Subjects
medicine.medical_specialty, medicine.medical_treatment, Ischemia, Laparotomy, Ascites, Intestine, Small, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Mesentery, Retrospective Studies, business.industry, General Medicine, medicine.disease, Helical ct, Spiral computed tomography, Bowel obstruction, medicine.anatomical_structure, Acute Disease, Tomography, Radiology, medicine.symptom, business, Tomography, Spiral Computed, Intestinal Obstruction
Abstract

Definite confirmation or exclusion closed loop obstruction (CLO) is one of the most difficult tasks the radiologist has to face in the clinical practice. Aim of this retrospective work was to study the value of spiral computed tomography (CT) in the diagnosis of closed loop obstruction complicated by intestinal ischemia. The state of the art CT signs of closed loop obstruction were taken into consideration. Serrated beaks with poor or no contrast enhancement of the bowel walls, ascites or engorgement of the mesenteric vasculature allowed the CT diagnosis of CLO complicated by ischaemia. U or C-sharped of dilated loops, radial distribution of the mesenteric vessels, beaks and whirls suggested CLO, but did not help differentiate CLO from strangulation. CLO is a dynamic entity which may regress or need laparotomy depending on the time and degree of rotation of the incarcerated loops. CT is a reliable imaging modality able to differentiate CLO from strangulation, which is rarely simple and obvious. Detection of ischemic changes in the bowel walls and/or attached mesentery on CT scans imply strangulation highlighting the need for laparotomy; if only signs of CLO are detected, the existence and/or development of strangulation cannot be predicted.

Published
2003

273. Insurers must manage information overload: transactional level data is a key building block for making quality decisions

Author

Flagiello, Michael and Wolin, Marc

Subjects
Insurance industry -- Finance -- Services, Associations, institutions, etc. -- Information management -- Finance -- Services, Company financing, Company systems management, Insurance industry, Business, Insurance
Abstract

MANY ORGANIZATIONS produce large quantities of data but are frustrated at the quality of information. The fact is that the majority of companies are ineffective when developing information metrics or [...]

Published
2010

274. A computationally efficient and interference tolerant nonparametric algorithm for LTI system identification based on higher-order cyclic statistics

Author

F. Flagiello, Luciano Izzo, and Antonio Napolitano

Subjects
LTI system theory, Mean squared error, Estimation theory, Signal Processing, Statistics, Linear system, System identification, Nonparametric statistics, Estimator, Higher-order statistics, Electrical and Electronic Engineering, Algorithm, Mathematics
Abstract

A new nonparametric algorithm for the identification of linear time-invariant systems is proposed. The method is based on the cyclic correlations of the input and output signals with a nonlinear transformation of the input signal. Consequently, although it exploits the higher order cyclostationarity properties of the input and output signals, its computational complexity is comparable with that of methods based on second-order statistics. The proposed estimator of the system transfer function is inherently immune to the presence of noise and interference on both input and output signal measurements and turns out to be asymptotically unbiased and consistent. Moreover, bias and variance of the estimate exhibit a rate of convergence to zero equal to that of estimates based on second-order statistics. Finally, simulation results show that the proposed algorithm significantly outperforms, in terms of both bias and variance of the estimates, several nonparametric identification algorithms previously presented in the literature.

Published
2000

275. Highly recurrent der(1;16)(q10;p10) and other 16q arm alterations in lobular breast cancer

Author

Xavier Sastre-Garau, Michèle Gerbault-Seureau, Bernard Dutrillaux, Philippe Vielh, D. Flagiello, and Eliane Padoy

Subjects
Adult, Cancer Research, Chromosomal translocation, Breast Neoplasms, Biology, Translocation, Genetic, Flow cytometry, Breast cancer, Genetics, Carcinoma, medicine, Humans, skin and connective tissue diseases, Aged, medicine.diagnostic_test, Carcinoma, Ductal, Breast, Karyotype, Middle Aged, medicine.disease, Flow Cytometry, Carcinoma, Lobular, Tumor progression, Chromosomes, Human, Pair 1, Chromosome Arm, Karyotyping, Cancer research, Female, Ploidy, Chromosomes, Human, Pair 16
Abstract

Cytogenetic data on infiltrating lobular carcinomas (ILCs) of the breast are described. In addition to 9 tumors, including 2 bilateral ones, with apparently normal chromosomes, recurrent chromosome alterations were found among 18 tumors. A der(1;16)(q10;p10), resulting in 1q gain and 16q loss, was observed in 11 tumors. Chromosome arm 16q was lost by other rearrangements in 3 other tumors. Thus, the deletion of 16q appears to be highly recurrent in ILCs. Compared to infiltrating ductal carcinomas (IDCs), ILCs have fairly simple karyotypes that remain pseudo- or near-diploid in most cases. This finding is confirmed by DNA ploidy studied by flow cytometry, which shows that about half of the tumors are diploid. This makes the der(1;16)(q10;p10) and other alterations of the 16q arm an early alteration of tumor progression, possibly related to the loss of expression of E-cadherin, whose gene is mapped on the 16q arm.

Published
1998

276. Expression and modulation of homeobox genes from cluster B in endothelial cells

Author

D, Belotti, N, Clausse, D, Flagiello, Y, Alami, M, Daukandt, C, Deroanne, B, Malfoy, E, Boncinelli, A, Faiella, and V, Castronovo

Subjects
Vascular Endothelial Growth Factor A, Lymphokines, O-(Chloroacetylcarbamoyl)fumagillol, Base Sequence, Transcription, Genetic, Vascular Endothelial Growth Factors, Molecular Sequence Data, Genes, Homeobox, Neovascularization, Physiologic, Endothelial Growth Factors, Umbilical Cord, Gene Expression Regulation, Cyclohexanes, Multigene Family, Tissue Plasminogen Activator, Humans, Tetradecanoylphorbol Acetate, Fibroblast Growth Factor 2, Endothelium, Vascular, Sesquiterpenes, Cell Division
Abstract

Angiogenesis is a complex phenomenon likely to be under the strict control of a group of transcription factor(s). Homeobox (HOX)-containing proteins have been identified as regulators controlling the coordinated expression of genes involved in organ development and tissue differentiation. In this study, we have demonstrated that human umbilical vein endothelial cells (HUVEC) express 8 of the 10 HOX genes contained in cluster B. Treatment of HUVEC with tissue plasminogen activator (TPA), an agent known to induce morphologic changes in endothelial cells, or vascular endothelium growth factor (VEGF), a proliferative and angiogenesis inducer, results in a specific time-dependent modulation of the eight HOX genes identified. Interestingly, neither basic fibroblast growth factor, an endothelial proliferative agent, nor TNP-470, a fumagillin derivative with potent antiendothelial cell proliferation properties, affected expression of these HOX genes. Specific modulation of HOX genes by differentiating agents but not by proliferative or antiproliferative molecules suggests that they could be involved in the control of the genetic program that coordinates the construction of new blood vessels.

Published
1998

277. Peptidoglycan and muropeptides from pathogens Agrobacterium and Xanthomonas elicit plant innate immunity:structure and activity

Author

Erbs, Gitte, Silipo, Alba, Aslam, Shazia, Castro, Cristina De, Liparoti, Valeria, Flagiello, Angela, Pucci, Pietro, Lanzetta, Rosa, Parrilli, Michelangelo, Molinaro, Antonio, Newman, Mari-Anne, Cooper, Richard M., Erbs, Gitte, Silipo, Alba, Aslam, Shazia, Castro, Cristina De, Liparoti, Valeria, Flagiello, Angela, Pucci, Pietro, Lanzetta, Rosa, Parrilli, Michelangelo, Molinaro, Antonio, Newman, Mari-Anne, and Cooper, Richard M.

Abstract

Peptidoglycan (PGN) is a unique and essential structural part of the bacterial cell wall. PGNs from two contrasting Gram-negative plant pathogenic bacteria elicited components characteristic of the innate immune system in Arabidopsis thaliana, such as transcription of the defense gene PR1, oxidative burst, medium alkalinization, and formation of callose. Highly purified muropeptides from PGNs were more effective elicitors of early defense responses than native PGN. Therefore, PGN and its constituents represent a Microbe-Associated Molecular Pattern (MAMP) in plant-bacterial interactions. PGN and muropeptides from aggressive Xanthomonas campestris pv. campestris were significantly more active than those from Agrobacterium tumefaciens, which must maintain host cell viability during infection. The structure of muropeptide components and the distinctive differences are described. Differing defense-eliciting abilities appear to depend on subtle structural differences in either carbohydrate or peptide groups.

Published
2008

279. Structural characterization and biological properties of human gastrokine 1

Author

Pavone, Luigi Michele, primary, Del Vecchio, Pompea, additional, Mallardo, Paolo, additional, Altieri, Filomena, additional, De Pasquale, Valeria, additional, Rea, Silviana, additional, Martucci, Nicola M., additional, Di Stadio, Chiara Stella, additional, Pucci, Pietro, additional, Flagiello, Angela, additional, Masullo, Mariorosario, additional, Arcari, Paolo, additional, and Rippa, Emilia, additional

Published
2013
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281. Temperature regulates expression of the Drosophila vestigial gene only in mutant wing discs

Author

A. Zider, J. L. Becker, J. Silber, R. Cossard, and D. Flagiello

Subjects
animal structures, Transcription, Genetic, Mutant, Genes, Insect, Biology, Transcription (biology), Genetics, Transcriptional regulation, Animals, Drosophila Proteins, Wings, Animal, Enhancer, Molecular Biology, Gene, Wing, Temperature, Nuclear Proteins, biology.organism_classification, Phenotype, Molecular biology, Enhancer Elements, Genetic, Gene Expression Regulation, Organ Specificity, Mutation, Drosophila, Drosophila melanogaster
Abstract

All Vestigial mutants in Drosophila melanogaster display a thermosensitive phenotype, with the exception of two which disrupt an intronic wing-specific enhancer element. Here we report a very unusual transcriptional regulation; temperature changes are associated with alterations in the level of νg expression only in the wing disc of thermosensitive mutant flies and not in the brain. No effect is observed in the wild-type strain. The tissue specificity of the temperature effect indicates an involvement of the intronic wing-specific enhancer element in determining the thermosensitivity of mutants.

Published
1997

282. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines

Author

Anne Gibaud, Domenico Flagiello, Bernard Dutrillaux, Bernard Malfoy, and Marie-France Poupon

Subjects
HOX gene, Biophysics, Retinoic acid, Tretinoin, Biology, Small cell lung carcinoma cell, Biochemistry, Polymerase Chain Reaction, Small-cell lung cancer, chemistry.chemical_compound, Structural Biology, Genetics, medicine, Tumor Cells, Cultured, Humans, RNA, Neoplasm, Carcinoma, Small Cell, Hox gene, Lung cancer, Molecular Biology, Gene, DNA Primers, Electrophoresis, Agar Gel, Homeodomain Proteins, Genes, Homeobox, RNA-Directed DNA Polymerase, Cell Biology, Neoplasms, Germ Cell and Embryonal, medicine.disease, Molecular biology, Embryonic stem cell, respiratory tract diseases, Gene Expression Regulation, Neoplastic, P19 cell, chemistry, Cell culture, Cancer research
Abstract

The expression patterns of the class I homeogenes HOXB and HOXC clusters in the presence of retinoic acid (RA) were studied in two human small-cell lung cancer (SCLC) cell lines and compared to that of NT2/D1 embryonal carcinoma cells. Contrasting with the sequential 3′-5′ induction of the HOX genes observed after RA treatment of embryonic NT2/D1 cells, in the SCLC cells the responding genes (induced or down-regulated) were interspersed with insensitive genes (expressed or unexpressed), while no genomic alteration affected the corresponding clusters. These findings imply that HOX gene regulatory mechanisms are altered in non-embryonic SCLC cells, perhaps reflecting their ability to respond to more diversified stimuli, in relation with their origin from adult tissues.

Published
1997

283. The signal detection system for the VIRGO interferometer

Author

Caron, B., Dominjon, A., Drezen, C., Flaminio, R., Grave, X., Marion, F., Massonnet, L., Mehmel, C., Morand, R., Mours, B., Yvert, M., Babusci, D., Giordano, G., Matone, G., Mackowski, J. M., Napolitano, M., Pinard, L., Dognin, L., Barone, Fabrizio, Calloni, E., Di Fiore, L., Flagiello, M., Grado, A., Longo, Maurizio, Lops, M., Marano, Stefano, Milano, L., Russo, G., Solimeno, S., Acker, Y., Brillet, A., Bondu, F., Brisson, V., Cavalier, F., Davier, M., Heitmann, H., Hello, P., Jacquemet, M., Latrach, L., Le Diberder, F., Man, C. N., Manh, P. T., Taubmann, M., Vinet, J. Y., Boccara, C., Gleyzes, P. h., Roger, J. P., Loriette, V., Cagnoli, G., Gammaitoni, L., Kovalik, J., Marchesoni, F., Punturo, M., Barsuglia, M., Bernardini, M., Braccini, S., Bradaschia, C., Del Fabbro, R., De Salvo, R., Di Virgilio, A., Ferrante, I., Fidecaro, F., Giassi, A., Giazotto, A., Gorini, G., Holloway, L., Lami, S., Lapenna, P., Losurdo, G., Mancini, S., Morganti, M., Palla, F., Pan, H. B., Passuello, D., Poggiani, R., Torelli, G., Zhang, Z., Majorana, E., Puppo, P., Rapagnani, P., Ricci, F., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and VIRGO

Subjects
Physics, Nuclear and High Energy Physics, Atom interferometer, Gravitational-wave observatory, 010308 nuclear & particles physics, Gravitational wave, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Measure (physics), Astronomy, Virgo interferometer, 01 natural sciences, General Relativity and Quantum Cosmology, Optics, 0103 physical sciences, Astronomical interferometer, Detection theory, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, business, Instrumentation
Abstract

Several interferometers devoted to the detection of gravitational waves are currently being built in Europe and in the USA. The detection of the tiny mirror displacements (10−18–10−19 m) induced by a gravitational wave requires to measure fringe variations between 10−10 and 10−11 fringes. The solutions adopted for the VIRGO interferometer are described.

Published
1997

285. Expressed STSs and transcription of human Xq28

Author

Raffaella Visone, Teresa Esposito, Rosa Anna Cifarelli, Alfredo Ciccodicola, Richard Mazzarella, Carmela Migliaccio, Maurizio D'Esposito, Michele D'Urso, Maria R. Matarazzo, Ciro Campanile, David Schlessinger, and Luisa Flagiello

Subjects
Genetics, Expressed sequence tag, DNA, Complementary, X Chromosome, Contig, Base Sequence, Transcription, Genetic, Molecular Sequence Data, Gene Expression, General Medicine, Biology, Blotting, Northern, Xq28, Sequence-tagged site, CpG site, Transcription (biology), Sequence Homology, Nucleic Acid, Gene expression, Humans, X chromosome, Sequence Tagged Sites
Abstract

STSs, which have been used to build and format clone contigs, have been used here to assemble a transcriptional map across a cytogenetic band. Of fifty one STSs in Xq28, 20 were positive by RT-PCR. Thus, an additional 20 possible ESTs were detected among the STSs, and seven of these also identified cDNAs in at least one library. The transcripts confirm the high expression level of this region, correlated with its GC compositional map and CpG island content.

Published
1997

286. The VIRGO interferometer for gravitational wave detection RID C-9235-2011 RID B-5375-2009 RID A-1920-2008

Author

Caron, B, Dominjon, A, Drezen, C, Flaminio, R, Grave, X, Marion, F, Massonnet, L, Mehmel, C, Morand, R, Mours, B, Sannibale, V, Yvert, M, Babusci, D, Bellucci, S, Candusso, S, Giordano, G, Matone, G, Mackowski, Jm, Pinard, L, Barone, F, Calloni, E, Difiore, L, Flagiello, M, Garuti, F, Grado, A, Longo, M, Lops, M, Marano, S, Milano, L, Solimeno, S, Brisson, V, Cavalier, F, Davier, M, Hello, P, Heusse, P, Mann, P, Acker, Y, Barsuglia, M, Bhawal, B, Bondu, F, Brillet, A, Heitmann, H, Innocent, Jm, Latrach, L, Man, Cn, Phamtu, M, Tournier, E, Taubmann, M, Vinet, Jy, Boccara, C, Gleyzes, P, Loriette, V, Roger, Jp, Cagnoli, G, Gammaitoni, L, Kovalik, J, Marchesoni, F, Punturo, M, Beccaria, M, Bernardini, M, Bougleux, E, Braccini, S, Bradaschia, C, Cella, G, Ciampa, A, Cuoco, E, Curci, G, Delfabbro, R, Desalvo, R, Divirgilio, A, Enard, D, Ferrante, Isidoro, Fidecaro, Francesco, Giassi, A, Giazotto, A, Holloway, L, Lapenna, P, Losurdo, G, Mancini, S, Mazzoni, M, Palla, F, Pan, Hb, Passuello, D, Pelfer, P, Poggiani, Rosa, Stanga, R, Vicere, A, Zhang, Z, Ferrari, V, Majorana, E, Puppo, P, Rapagnani, P, and Ricci, F.

Published
1997

289. Autosomal-dominant retinitis pigmentosa associated with an Arg-135-Trp point mutation of the rhodopsin gene. Clinical features and longitudinal observations

Author

M R, Pannarale, B, Grammatico, A, Iannaccone, R, Forte, C, DeBernardo, L, Flagiello, E M, Vingolo, and G, Del Porto

Subjects
Adult, Male, Rhodopsin, Adolescent, Tryptophan, DNA, Arginine, Polymerase Chain Reaction, Retina, Pedigree, Phenotype, Electroretinography, Humans, Point Mutation, Female, Longitudinal Studies, Visual Fields, Child, Polymorphism, Single-Stranded Conformational, Retinitis Pigmentosa
Abstract

To report the clinical and functional characteristics of patients affected with autosomal-dominant transmitted retinitis pigmentosa (adRP) from a large Italian pedigree in which a point mutation predicting the Arg-135-Trp change of rhodopsin was identified by polymerase chain reaction-single-strand conformation polymorphism analysis.Seven patients, ranging in age from 6 to 41 years, underwent a full clinical ophthalmologic evaluation, kinetic visual field testing, and electroretinographic testing.In agreement with previous reports, this rhodopsin mutation yielded a particularly severe phenotype, both clinically and functionally. The evaluation of patients from this pedigree in the first and second decade of life demonstrated that retinal function is still electroretinographically measurable at least until 18 years of age, although reduced to 2% to 4% of normal. Longitudinal measures showed that the rate of progression of the disease was unusually high, with an average 50% loss per year of electroretinographic amplitude and visual field area with respect to baseline. Later in the course of the disease, macular function is also severely compromised, leaving only residual central vision by the fourth decade of life.The phenotype associated with mutations in codon 135 of the rhodopsin molecule appears to have an unusually high progression rate and yields an extremely poor prognosis. These distinctive features make the Arg-135-Trp phenotype substantially different from the general RP population, and also from many of the other adRP pedigrees with known rhodopsin mutations reported to date.

Published
1996

290. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation

Author

Maurizio D'Esposito, Richard Mazzarella, Fernando Gianfrancesco, David Schlessinger, Luisa Flagiello, Teresa Esposito, Michele D'Urso, and Alfredo Ciccodicola

Subjects
Male, X Chromosome, Transcription, Genetic, Pseudoautosomal region, Molecular Sequence Data, Biology, Hybrid Cells, Y chromosome, X-inactivation, R-SNARE Proteins, Ribonucleases, Gene mapping, Dosage Compensation, Genetic, Y Chromosome, Genetics, Humans, Amino Acid Sequence, Gene, Chromosomes, Artificial, Yeast, X chromosome, Dosage compensation, Base Sequence, Sequence Homology, Amino Acid, Arabidopsis Proteins, Membrane Proteins, Xq28, Gene Expression Regulation
Abstract

The X and Y chromosomes that maintain human dimorphism are thought to have descended from a single progenitor, with the Y chromosome becoming largely depleted of genes1. A number of genes, however, retain copies on both X and Y chromosomes and escape the inactivation that affects most X-linked genes in somatic cells2. Many of those genes are present in two pseudoautosomal regions (PARs) at the termini of the short (p)3 and long (q)4,5 arms of the sex chromosomes. For both PARs, pairing facilitates the .exchange of information, ensuring the homogeni-sation of X and Y chromosomal material in these regions6–10. We report here a strikingly different regulation of expression of a gene in Xq PAR. Unlike all Xp PAR genes studied so far, a synaptobrevin-like gene, tentatively named SYBL1, undergoes X inactivation. In addition, it is also inactive on the Y chromosome, thereby maintaining dosage compensation in an unprecedented way.

Published
1996

291. The virgo suspension system

Author

Caron, B., Dominjon, A., Flaminio, R., Grave, X., Marion, F., Massonnet, L., Mehmel, C., Morand, R., Mours, B., Sannibale, V., Yvert, M., Babusci, D., Bellucci, S., Candusso, S., Giordano, G., Matone, G., Mackowski, J.-M., Pinard, L., Boccara, C., Gleizes, P., Loriette, V., Roger, J.P., Pelfer, P.G., Stanga, R., Barone, F., Calloni, E., Di Fiore, L., Flagiello, M., Garufi, F., Grado, A., Longo, M., Lops, M., Milano, L., Marano, S., Solimeno, S., Acker, Y., Barsuglia, M., Bondu, François, Brillet, A., Brisson, V., Cavalier, F., Davier, M., Heitmann, H., Hello, P., Latrach, L., Le Diberder, F., Nary Man, C., Manh, P.T., Taubman, M., Vinet, J.Y., Cagnoli, G., Gammaitoni, L., Kovalik, J., Marchesoni, F., Punturo, M., Beccaria, M., Bernardini, M., Braccini, S., Bradaschia, C., Cella, G., Ciampa, A., Cuoco, E., Curci, G., De Salvo, R., Del Fabbro, R., Di Virgilio, A., Enard, D., Ferrante, I., Fidecaro, F., Giazotto, A., Giassi, A., Gorini, G., Hollloway, L., La Penna, P., Losurdo, G., Luiten, A., Morganti, M., Palla, F., Pan, H.B., Passuello, D., Poggiani, R., Torelli, G., Vicere, A., Winterflood, J., Woode, R., Zhang, Z., Majorana, E., Puppo, P., Rapagnani, P., Ricci, F., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), VIRGO, Laboratoire d'Annecy de Physique des Particules (LAPP), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique Nucléaire de Lyon ( IPNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), and Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], [ PHYS.ASTR.CO ] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]
Published
1996

292. State of the art of the Virgo experiment

Author

Caron, B., Dominjon, A., Drezen, C., Flaminio, R., Grave, X., Marion, F., Massonnet, L., Mehmel, C., Morand, R., Mours, B., Sannibale, V., Yvert, M., Babusci, D., Bellucci, S., Candusso, S., Giordano, G., Matone, G., Mackowski, J.-M., Pinard, L., Boccara, C., Gleizes, P., Loriette, V., Roger, J.P., Pelfer, P.G., Stanga, R., Barone, F., Calloni, E., Di Fiore, L., Flagiello, M., Garufi, F., Grado, A., Longo, M., Lops, M., Milano, L., Marano, S., Solimeno, S., Barsuglia, M., Bhawal, B., Bondu, François, Brillet, A., Brisson, V., Cavalier, F., Davier, M., Heitmann, H., Hello, P., Heusse, P., Innocent, J.M., Latrach, L., Le Diberder, F., Nary Man, C., Marin, P., Pham-Tu, M., Taubman, M., Tournier, E., Vinet, J.Y., Bernardini, M., Braccini, S., Bradaschia, C., Casciano, C., Cella, G., Ciampa, A., Cuoco, E., Curci, G., De Salvo, R., Del Fabbro, R., Di Virgilio, A., Fidecaro, F., Gaddi, A., Gennai, A., Giazotto, A., Gorini, G., La Penna, P., Losurdo, G., Mancini, S., Pan, H.B., Pasqualetti, A., Passuello, D., Poggiani, R., Popolizio, P., Raffaelli, F., Vicere, A., Zhang, Zhen, Bronzini, F., Ferrari, V., Majorana, E., Puppo, P., Rapagnani, P., Ricci, F., Holloway, L., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), VIRGO, Laboratoire d'Annecy de Physique des Particules (LAPP), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Information seeking and use models, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], information practices, information access models, professional information
Abstract

This study concerns information seeking and use models for professionals and their evolutions essentially, i.e. Information Access Practices. Coming from Anglo-Saxon literature, this new research trend evolves with the development of information science paradigms. So different information seeking and use models emerge in order to explain how professionals seek information and what can be done in order to help them. Two main categories can be distinguished: information seeking and use models versus the information retrieval models. So we will present today these models' diversity and we will evaluate them in order to see if a convergence is possible with the same vocabulary and procedures.

Published
1996

294. Upregulation of urokinase-type plasminogen activator in squamous cell carcinoma of human larynx

Author

D. Flagiello, Johnny Cappiello, Marco Presta, Silvia Parolini, M. P. Molinari Tosatti, A. Cinquetti, S. Cristini, R. Gozzi, Marco Rusnati, and Piero Nicolai

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Stromal cell, Biology, Antigens, Neoplasm, Reference Values, medicine, Carcinoma, Humans, Zymography, RNA, Messenger, Neoplasm Metastasis, Lymph node, Laryngeal Neoplasms, In Situ Hybridization, Urokinase, medicine.disease, Immunohistochemistry, Urokinase-Type Plasminogen Activator, Up-Regulation, medicine.anatomical_structure, Oncology, Epidermoid carcinoma, Laryngeal Mucosa, Carcinoma, Squamous Cell, Plasminogen activator, medicine.drug, Research Article
Abstract

The expression of urokinase-type plasminogen activator (uPA) was investigated in squamous cell carcinoma of the human larynx. For this purpose, tissue extracts from 25 matched samples of normal mucosa and neoplastic larynx were compared for the levels of uPA activity as evaluated by a chromogenic PA assay and sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) zymography. Also, uPA antigen was quantified by enzyme-linked immunosorbent assay (ELISA) in 19 cases. The results demonstrate a significant increase in the levels of uPA activity and protein in tumour tissue extracts, more pronounced in tumours with lymph node metastases. Immunohistochemistry performed on 70 biopsies showed that uPA positivity is present both in neoplastic cells and in fibroblast-like cells and macrophages. However, depending on the histological grading and invasive capacity of the tumour, a pronounced intra- and intertumoral heterogeneity in uPA staining was observed. In situ hybridisation confirmed the presence of uPA mRNA in both tumour and stromal cells. The present study provides experimental evidence for a role of uPA in the invasive growth of human laryngeal carcinoma. Images Figure 2 Figure 3 Figure 4

Published
1996

295. Status of the VIRGO experiment RID B-5375-2009 RID A-1920-2008

Author

Caron, B, Dominjon, A, Drezen, C, Flaminio, R, Grave, X, Marion, F, Massonnet, L, Mehmel, C, Morand, R, Mours, B, Yvert, M, Babusci, D, Giordano, G, Matone, G, Mackowski, Jm, Napolitano, M, Pinard, L, Dognin, L, Barone, F, Calloni, E, Difiore, L, Flagiello, M, Grado, A, Longo, M, Lops, M, Marano, S, Milano, L, Russo, G, Solimeno, S, Acker, Y, Brillet, A, Bondu, F, Brisson, V, Cavalier, F, Davier, M, Heitmann, H, Hello, P, Jacquemet, M, Latrach, L, Lediberder, F, Man, Cn, Manh, Pt, Taubmann, M, Vinet, Jy, Boccara, C, Gleyzes, P, Roger, Jp, Loriette, V, Cagnoli, G, Gammaitoni, L, Kovalik, J, Marchesoni, F, Punturo, M, Barsuglia, M, Bernardini, M, Braccini, S, Bradaschia, C, Delfabbro, R, Desalvo, R, Divirgilio, A, Ferrante, Isidoro, Fidecaro, Francesco, Giassi, A, Giazotto, A, Gorini, G, Holloway, L, Lami, S, Lapenna, P, Losurdo, G, Mancini, S, Morganti, M, Palla, F, Pan, Hb, Passuello, D, Poggiani, Rosa, Torelli, G, Zhang, Z, Majorana, E, Puppo, P, Rapagnani, P, and Ricci, F.

Published
1996

296. HOX genes and cell adhesion molecules in cancers

Author

A, Alonso Varona, B, Castro, Y, Calle, T, Palomares, P, Bilbao, D, Flagiello, M F, Poupon, and B, Malfoy

Subjects
Gene Expression Regulation, Neoplastic, Mice, Lung Neoplasms, Multigene Family, Transplantation, Heterologous, Genes, Homeobox, Tumor Cells, Cultured, Animals, Humans, Mice, Nude, Carcinoma, Small Cell, Cell Adhesion Molecules, Neoplasm Transplantation
Published
1996

297. Suspension of detection masses for the virgo interferometer

Author

Caron, B., Dominjon, A., Drezen, C., Flaminio, R., Grave, X., Marion, F., Massonnet, L., Mehmel, C., Morand, R., Mours, B., Yvert, M., Babusci, D., Giordano, G., Matone, G., Mackowski, J. M., Napolitano, M., Pinard, L., Dognin, L., Barone, Fabrizio, Calloni, E., Di Fiore, L., Flagiello, M., Grado, A., Longo, Maurizio, Lops, M., Marano, Stefano, Milano, L., Russo, G., Solimeno, S., Acker, Y., Brillet, A., Bondu, F., Brisson, V., Cavalier, F., Heitmann, M. Davier H., Hello, P., Jacquemet, M., Latrach, L., Le Diberder, F., Man, C. N., Manh, P. T., Taubmann, M., Vinet, J. Y., Boccara, C., Gleyzes, P. h., Roger, J. P., Loriette, V., Cagnoli, G., Gammaitoni, L., Kovalik, J., Marchesoni, F., Punturo, M., Barsuglia, M., Bernardini, M., Braccini, S., Bradaschia, C., Del Fabbro, R., De Salvo, R., Di Virgilio, A., Ferrante, I., Fidecaro, F., Giassi, A., Giazotto, A., Gorini, G., Holloway, L., Lami, S., Lapenna, P., Losurdo, G., Mancini, S., Morganti, M., Palla, F., Pan, H. B., Passuello, D., Poggiani, R., Torelli, G., Zhang, Z., Majorana, E., Puppo, P., Rapagnani, P., and Ricc, F.

Subjects
Physics, Nuclear and High Energy Physics, Interferometry, Optics, business.industry, Gravitational wave, Astrophysics::Instrumentation and Methods for Astrophysics, Virgo interferometer, Sensitivity (control systems), Seismic noise, Suspension (vehicle), business, Atomic and Molecular Physics, and Optics
Abstract

The masses used by the Virgo interferometer to detect gravitational waves need adequate isolation from seismic noise. A multistage suspension system has been designed to extend the interferometer sensitivity down around 4 Hz. Motivations for this choice and an outline of the solutions adopted are given.

Published
1996

299. Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua

Author

Riccio, Alessia, primary, Mangiapia, Gaetano, additional, Giordano, Daniela, additional, Flagiello, Angela, additional, Tedesco, Roberta, additional, Bruno, Stefano, additional, Vergara, Alessandro, additional, Mazzarella, Lelio, additional, di Prisco, Guido, additional, Pucci, Piero, additional, Paduano, Luigi, additional, and Verde, Cinzia, additional

Published
2011
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300. Lipovitellin constitutes the protein backbone of glycoproteins involved in sperm-egg interaction in the amphibianDiscoglossus pictus

Author

Campanella, C., primary, Caputo, M., additional, Vaccaro, M.C., additional, De Marco, N., additional, Tretola, L., additional, Romano, M., additional, Prisco, M., additional, Camardella, L., additional, Flagiello, A., additional, Carotenuto, R., additional, Limatola, E., additional, Polzonetti-Magni, A., additional, and Infante, V., additional

Published
2011
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