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The Primordial Inflation Polarization Explorer (PIPER) is a stratospheric balloon payload to measure the polarization of the cosmic microwave background. Twin telescopes mounted within an open-aperture bucket dewar couple the sky to bolometric detector arrays. We reduce detector loading and photon noise by cooling the entire optical chain to 1.7 K or colder. A set of fountain-effect pumps sprays superfluid liquid helium onto each optical surface, producing helium flows of 50–100 cm3 s−1 at heights up to 200 cm above the liquid level. We describe the fountain-effect pumps and the cryogenic performance of the PIPER payload during two flights in 2017 and 2019. [ABSTRACT FROM AUTHOR]

This Voyage 2050 paper highlights the unique science opportunities using spectral distortions of the cosmic microwave background (CMB). CMB spectral distortions probe many processes throughout the history of the Universe, delivering novel information that complements past, present and future efforts with CMB anisotropy and large-scale structure studies. Precision spectroscopy, possible with existing technology, would not only provide key tests for processes expected within the cosmological standard model but also open an enormous discovery space to new physics. This offers unique scientific opportunities for furthering our understanding of inflation, recombination, reionization and structure formation as well as dark matter and particle physics. A dedicated experimental approach could open this new window to the early Universe in the decades to come, allowing us to turn the long-standing upper distortion limits obtained with COBE/FIRAS some 25 years ago into clear detections of the expected standard distortion signals and also challenge our current understanding of the laws of nature. [ABSTRACT FROM AUTHOR]

We present results from laboratory detector characterizations of the first kilopixel BUG arrays for the High- resolution Wideband Camera Plus (HAWC+) which is the imaging far-infrared polarimeter camera for the Stratospheric Observatory for Infrared Astronomy (SOFIA). Our tests demonstrate that the array performance is consistent with the predicted properties. Here, we highlight results obtained for the thermal conductivity, noise performance, detector speed, and first optical results demonstrating the pixel yield of the arrays. [ABSTRACT FROM AUTHOR]

The traditional method of applying a digital optimal filter to measure X-ray pulses from transition-edge sensor (TES) devices does not achieve the best energy resolution when the signals have a highly non-linear response to energy, or the noise is non-stationary during the pulse. We present an implementation of a method to analyze X-ray data from TESs, which is based upon principal component analysis (PCA). Our method separates the X-ray signal pulse into orthogonal components that have the largest variance. We typically recover pulse height, arrival time, differences in pulse shape, and the variation of pulse height with detector temperature. These components can then be combined to form a representation of pulse energy. An added value of this method is that by reporting information on more descriptive parameters (as opposed to a single number representing energy), we generate a much more complete picture of the pulse received. Here we report on progress in developing this technique for future implementation on X-ray telescopes. We used an $$^{55}$$ Fe source to characterize Mo/Au TESs. On the same dataset, the PCA method recovers a spectral resolution that is better by a factor of two than achievable with digital optimal filters. [ABSTRACT FROM AUTHOR]

Introduction: The Hurley staging system is a grading system utilized to measure hidradenitis suppurativa (HS) severity. Teaching patients to grade the severity of HS may aid in the accuracy of self-reporting for research and clinical purposes. Thus, this study aimed to determine the utility of a Hurley stage learning module (HSLM) for participants to grade images of HS., Methods: An anonymous survey was distributed online between October 2021 and January 2022. Participants completed a 5-min HSLM and a 9-item Hurley staging quiz with varying Fitzpatrick skin tones and HS severity. Comparative statistics were completed using t tests. p value of <0.05 was considered significant., Results: Majority of participants were female (95.2%, 263/276) and white (81.5%, 225/276). In terms of the percentage of quiz questions correct: 77.9% of respondents graded the Hurley stage 1 images correctly, 79.3% for Hurley stage 2, and 100% for Hurley stage 3. There was a significant difference in confidence of rating Hurley stage for any image (3.66 ± 1.18 vs. 4.39 ± 0.83; p < 0.0001) and own Hurley stage (3.90 ± 1.19 vs. 4.54 ± 0.81; p < 0.0001) pre- and post-HSLM., Conclusion: An HSLM provides high level of accuracy and increased participant confidence to grade their own disease and images of HS. An HSLM is an effective, cost-efficient, and valuable tool to facilitate clinical and survey research by allowing patients to report disease severity with increased confidence., Competing Interests: Dr. Shi is on the board of directors for the Hidradenitis Suppurativa Foundation; is a stock shareholder of Learn Health; and has served as an advisory board member, investigator, speaker, and/or received research funding from Sanofi Genzyme, Regeneron, AbbVie, Eli Lilly, Novartis, SUN Pharma, LEO Pharma, Pfizer, Incyte, Boehringer Ingelheim, Aristea Therapeutics, Menlo Therapeutics, Dermira, Burt’s Bees, Galderma, Kiniksa, UCB, Target-PharmaSolutions, Altus Lab/cQuell, MYOR, Polyfins Technology, GpSkin, Skin Actives Scientific, and the National Eczema Association. Dr. Hsiao is on the board of directors for the Hidradenitis Suppurativa Foundation and has served as a consultant for AbbVie, Aclaris, Boehringer Ingelheim, Incyte, Novartis, UCB; as a speaker for AbbVie; as an investigator for Amgen, Boehringer Ingelheim, and Incyte. Authors Fixsen and Brooks are cofounders of HSConnect, a non-profit organization which has received funding from Novartis, UCB, Inctye, Sanofi, and Acelyrin. De, Dagenet, Shih, Park, and Tran have no disclosures., (© 2024 S. Karger AG, Basel.)

Introduction: Hidradenitis suppurativa (HS) is an inflammatory dermatosis for which the treatment paradigm is rapidly expanding. We aimed to identify HS patient perspectives and barriers on biologics., Methods: An anonymous survey was distributed between 10/2021 and 1/2022 through HS support groups. Data regarding demographics and perspectives on biologics were collected and analyzed., Results: Of the 196 respondents, 92% were female (180/196) and 75% were white (147/196). 89.3% had Hurley stage 2/3 HS (102/195). The primary healthcare provider (HCP) for HS in 65% (128/196) of patients was a dermatologist, with 12% (23/196) seen at an HS specialty clinic. Most respondents never tried a biologic medicine (62%, 118/192). The top barriers to biologics were fear of side effects (61%, 109/179), high cost/lack of insurance coverage (46%, 83/179), frequency of weekly injections (32%, 58/179). Respondents reporting their main HCP as a non-dermatologist (4.11 vs 3.0, p  < .0001) and not seen at a HS specialty clinic (3.5 vs 2.7, 0.039) were significantly more likely to agree 'I do not know enough about how biologics work to help my HS'., Conclusion: Our results highlight the importance of specialty care in the education and implementation of biologics. Patients may benefit from comprehensive discussion prior to starting biologics.

Competing Interests: Conflicts of Interest: J.L.H. is on the Board of Directors for the Hidradenitis Suppurativa Foundation, has served as a consultant for Boehringer-Ingelheim, Novartis, and UCB, and has served as a consultant and speaker for AbbVie. V.Y.S. is on the board of directors for the Hidradenitis Suppurativa Foundation (HSF), is a stock shareholder of Learn Health and has served as an advisory board member, investigator, speaker, and/or received research funding from Sanofi Genzyme, Regeneron, AbbVie, Eli Lilly, Novartis, SUN Pharma, LEO Pharma, Pfizer, Incyte, Boehringer-Ingelheim, Aristea Therapeutics, Menlo Therapeutics, Dermira, Burt’s Bees, Galderma, Kiniksa, UCB, WebMD, TARGET-Pharmasolutions, Altus Lab, MYOR, Polyfin, GpSkin and Skin Actives Scientific. There was no financial transaction for the preparation of this manuscript. All other authors report no conflicts of interest.

Problem: As the evidence-based movement has advanced in public health, changes in public health practices have lagged far behind creating a science to service gap. For example, science has produced effective falls prevention interventions for older adults. It now is clearer WHAT needs to be done to reduce injury and death related to falls. However, issues have arisen regarding HOW to assure the full and effective uses of evidence-based programs in practice., Summary: Lessons learned from the science and practice of implementation provide guidance for how to change practices by developing new competencies, how to change organizations to support evidence-based practices, and how to change public health systems to align system functions with desired practices. The combination of practice, organization, and system change likely will produce the public health benefits that are the promise of evidence-based falls prevention interventions. IMPACT ON PUBLIC HEALTH: For the past several decades, the emphasis has been solely on evidence-based interventions. Public health will benefit from giving equal emphasis to evidence-based implementation., Impact on Industry: We now have over two decades of research on the effectiveness of fall prevention interventions. The quality of this research is judged by a number of credible international organizations, including the Cochrane Collaboration (http://www.cochrane.org/), the American and British Geriatrics Societies, and the Campbell Collaboration (http://www.campbellcollaboration.org/). These international bodies were formed to ponder and answer questions related to the quality and relevance of research. These developments are a good first step. However, while knowing WHAT to do (an evidence-based intervention) is critical, we also need to know HOW to effectively implement the evidence. Implementation, organization change, and system change methods produce the conditions that allow and support the full and effective use of evidence-based interventions. It is time to focus on utilization of implementation knowledge in public health. Without this focus the vast amount on new evidence being generated on the prevention of falls and related injuries among older adults will have little impact on their health and safety., (Copyright © 2011 National Safety Council and Elsevier Ltd. All rights reserved.)

Background: Children with emotional and behavioural disorders should be able to count on receiving care that meets their needs and is based on the best scientific evidence available, however, many do not receive these services. Implementation of evidence-based practice (EBP) relies, in part, on the research utilization practices of mental health care providers. This study reports on a survey of research utilization practices among 80 children's mental health (CMH) service provider organizations in Ontario, Canada., Methods: A web-based survey was distributed to 80 CMH service provider organizations, to which 51 executive directors and 483 children's mental health practitioners responded. Research utilization was assessed using questions with Likert-type responses based on the Canadian Health Services Research Foundation's Four-A's approach: access, assess, adapt, apply., Results: There was general agreement among executive directors and practitioners regarding the capacity of their organizations to use - access, assess, adapt, and apply - research evidence. Overall, both groups rated their organizations as using research information 'somewhat well.' The low response rate to the practitioner survey should be noted., Conclusion: These findings provide a useful benchmark from which changes in reported research utilization in the Ontario CMH sector can be tracked over time, as a function of EBP training and implementation initiatives, for instance. The need to improve access to research evidence should be addressed because it relates to the eventual implementation and uptake of evidence-based practices. Communities of practice are recommended as a strategy that would enable practitioners to build capacity in their adaptation and application of research evidence.

Program development and dissemination in human services present challenges and opportunities for social scientists. Over the past 27 years the Teaching-Family Model of group home treatment has moved from prototype development to widespread dissemination across North America. Reviewing concepts in industry related to product development and dissemination, the application of these concepts to a human services delivery system, and program replication and dissemination data offer information about how innovative human services can be widely adapted and adopted.

This research sought to identify, train, and validate social behaviors preferred by youths to be used by youth-care personnel (called teaching-parents). With training, consistent increases in seven preferred behaviors were observed for the six teaching-parent trainees. These behaviors included offering to help, "getting to the point", giving reasons why a behavior is important to a youth, providing descriptions of alternative behaviors, positive feedback, smiling, and positive motivational incentives (i.e., points for task mastery exchanged for tangible reinforcers). Increases in these behaviors correlated with increases in the youths' ratings of the quality of the trainees' interactions. Posttraining levels of preferred social behavior and youth ratings for trainees also compared favorably with levels for successful professional teaching-parents. These results suggest that teaching-parents can be successfully trained to interact with youths in ways that are preferred by the youths.

Three reliably measured components of conversation-questioning, providing positive feedback, and proportion of time spent talking-were identified and validated as to their social importance. The social validity of the three conversational behaviors was established with five female university students and five female junior-high students. Each was videotaped in conversations with previously unknown adults. The conversational ability of each girl was evaluated by a group of 13 adult judges who viewed each tape and rated each conversant "poor" to "excellent" on a seven-point rating scale. The average ratings of the girls correlated at r = 0.85 with the specified behavioral measures. These procedures were replicated with additional subjects and judges and yielded a correlation of r = 0.84. The high correlations between ratings and the objective measures suggested that the specified conversational behaviors were socially important aspects of conversational ability. Employing a multiple-baseline design across the behaviors of asking questions and providing positive feedback, an attempt was made to train four girls who used these behaviors minimally to engage in the behaviors in conversations with adults. Adult judges were again employed to rate randomly selected samples of the girls' skills in pre- and posttraining conversations. The average ratings of the girls before training were lower than both the university girls and the junior high-school girls. After training, the girls' conversational abilities were rated substantially higher than those of their junior high-school peers. These rating data validated the benefits of the training and the social importance of the behavioral components of questions and feedback in conversation. The authors suggest that it may be necessary for traditional behavior analysis measurement systems to be supplemented by social-validation procedures in order to establish the relationship between "objectively" measured behaviors and complex classes of behavior of interest to society.

One of the goals of many treatment programs for pre-delinquent youths is the development of the skills involved in the democratic decision-making process. At Achievement Place, one aspect of the treatment program is a semi-self-government system whereby the seven pre-delinquent youths can democratically establish many of their own rules of behavior, monitor their peers' behavior to detect violations of their rules, and conduct a "trial" to determine a rule violator's guilt or innocence, and to determine the consequences for a youth who violates a rule. Two experiments were carried out to determine the role of some of the procedures in the boys' participation in the self-government system. Experiment I showed that more boys participated in the discussion of consequences for a rule violation when they had complete responsibility for setting the consequence during the trials than when the teaching-parents set the consequence for each rule violation before the trial. An analysis of the rule violations in this experiment indicated that the boys in Achievement Place reported more of the rule violations that resulted in trials than reported by the teaching-parents or school personnel. The boys reported rule violations that occurred in the community and school as well as at Achievement Place, including most of the serious rule violations that came to the attention of the teaching-parents. In Experiment II, the results indicated that more trials were called when the teaching-parents were responsible for calling trials on rule violations reported by the peers than when the boys were responsible for calling trials. When the youths earned points for calling trials the average number of trials per day increased, but more trivial rule violations were reported. These results suggest that aspects of the democratic decision-making process in a small group of pre-delinquents can be studied and variables that affect participation can be identified and evaluated.

The reliability of the boys reporting their own behavior of their peers was measured in two experiments at Achievement Place, a community based, family style, behavior modification program for delinquents based on a token (point) economy. The results of these experiments indicated that; (a) the boys were not "naturally" reliable observers, (b) the reliability of peer-reporting could be improved by providing training on the behavioral definitions and by making points contingent on agreement between each boy's peer-report and an independent adult observers' report, (c) the reliability of self-reporting could be improved by making points contingent on agreement between the self-report and the trained peer's report, and (d) giving self-reports and peer-reports did not produce a systematic effect on the boys' room-cleaning behavior as measured by an independent observer.

A series of experiments was carried out to compare several administrative systems at Achievement Place, a family style behavior modification program for pre-delinquent boys. One aspect of the motivation system at Achievement Place was the token economy in which the youths could earn or lose points that could be exchanged for privileges. Several arrangements for assigning routine tasks and for providing token consequences for task performance were compared for their effectiveness in accomplishing the tasks and for their preference by the boys. The independent variables studied included: (1) individually assigned tasks versus group assigned tasks; (2) consequences for individual performance versus consequences for group performance; (3) a peer managership that could be earned by the highest bidder versus a peer managership that could be determined democratically by the peers. The results suggested that among those systems studied the system that best met the criteria of effectiveness and preference involved a democratically elected peer manager who had the authority both to give and to take away points for his peers' performances.

The "pre-delinquent" behaviors of six boys at Achievement Place, a community based family style behavior modification center for delinquents, were modified using token (points) reinforcement procedures. In Exp. I, point losses contingent on each minute late were effective in producing promptness at the evening meal. During the reversal phase, threats (which were not backed up with point losses) to reinstate the point consequences initially improved promptness but the last two of five threats were ineffective. In Exp. II, point consequences effectively maintained the boys' room-cleaning behavior and, during a fading condition where the percentage of days when the contingency occurred was decreased, the point consequences remained effective for over six months, even when they were delivered on only 8% of the days. Experiment III showed that the boys saved considerable amounts of money when point consequences were available for deposits but saved little money when no points were available. Also, when points were given only for deposits that occurred on specific days the boys deposited their money almost exclusively on those days. In Exp. IV, point consequences contingent on the number of correct answers on a news quiz produced the greatest increase in the percentage of boys who watched the news and, to a lesser extent, increased the percentage of correct answers for the boys who watched the news. The results indicate that "pre-delinquent" behaviors are amenable to modification procedures and that a token reinforcement system provides a practical means of modifying these behaviors.