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1,446 results on '"Ferreira, Joaquim J."'

252. Recommendations for the Organization of Multidisciplinary Clinical Care Teams in Parkinson’s Disease

Author

Radder, Danique L.M., primary, Nonnekes, Jorik, additional, van Nimwegen, Marlies, additional, Eggers, Carsten, additional, Abbruzzese, Giovanni, additional, Alves, Guido, additional, Browner, Nina, additional, Chaudhuri, K. Ray, additional, Ebersbach, Georg, additional, Ferreira, Joaquim J., additional, Fleisher, Jori E., additional, Fletcher, Peter, additional, Frazzitta, Giuseppe, additional, Giladi, Nir, additional, Guttman, Mark, additional, Iansek, Robert, additional, Khandhar, Suketu, additional, Klucken, Jochen, additional, Lafontaine, Anne-Louise, additional, Marras, Connie, additional, Nutt, John, additional, Okun, Michael S., additional, Parashos, Sotirios A., additional, Munneke, Marten, additional, and Bloem, Bastiaan R., additional

Published
2020
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259. Efficacy of Opicapone as First-Line Adjunctive Levodopa Treatment in Parkinson’s Disease Patients with Motor Fluctuations: a Post-Hoc Analysis from Double-Blind Combined BIPARK-I and II Data (1502)

Author

Hauser, Robert, primary, Ferreira, Joaquim J., additional, Poewe, Werner, additional, Antonini, Angelo, additional, Rocha, José-Francisco, additional, Magalhães, Diogo, additional, Soares-da-Silva, Patricio, additional, Klepitskaya, Olga, additional, and Liang, Grace, additional

Published
2020
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270. Additional file 1 of A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

Author

Simões, Rita Moiron, Caldas, Ana Castro, Grilo, Joana, Correia, Daisy, Guerreiro, Carla, Lobo, Patrícia Pita, Valadas, Anabela, Fabbri, Marguerita, Guedes, Leonor Correia, Coelho, Miguel, Rosa, Mario Miguel, Ferreira, Joaquim J., and Reimão, Sofia

Abstract

Additional file 1: Additional Table 1 Qualitative and quantitative analysis of SN and LC in NM-sensitive MRI and SWI.

Published
2020
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271. Additional file 2 of A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

Author

Simões, Rita Moiron, Caldas, Ana Castro, Grilo, Joana, Correia, Daisy, Guerreiro, Carla, Lobo, Patrícia Pita, Valadas, Anabela, Fabbri, Marguerita, Guedes, Leonor Correia, Coelho, Miguel, Rosa, Mario Miguel, Ferreira, Joaquim J., and Reimão, Sofia

Subjects
stomatognathic system, nervous system, parasitic diseases, mental disorders, nervous system diseases
Abstract

Additional file 2: Additional Table 2 Morphometrics in MSA-P, PD with 2 to 5 years duration and healthy controls. (PD: Parkinson’s disease, MSA: multiple system atrophy, MSA-P: MSA parkinsonian variant, MRI: magnetic resonance imaging, SN: substantia nigra, LC: locus coeruleus, MCP: middle cerebellar peduncle, SCP: superior cerebellar peduncle). ¥ - Mean value is presented, as differences between left and right measurements were not significant . Bold values mean significant statistical differences.

Published
2020
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272. Motor, cognitive and mobility deficits in 1000 geriatric patients: a protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study

Author

Geritz, Johanna, Maetzold, Sara, Steffen, Maren, Pilotto, Andrea, Corrà, Marta F., Moscovich, Mariana, Rizzetti, Maria C., Borroni, Barbara, Padovani, Alessandro, Alpes, Annekathrin, Bang, Corinna, Barcellos, Igor, Baron, Ralf, Bartsch, Thorsten, Becktepe, Jos S., Berg, Daniela, Bergeest, Lu M., Bergmann, Philipp, Bouça-Machado, Raquel, Drey, Michael, Elshehabi, Morad, Farahmandi, Susan, Ferreira, Joaquim J., Franke, Andre, Friederich, Anja, Geisler, Corinna, Hüllemann, Philipp, Gierthmühlen, Janna, Granert, Oliver, Heinzel, Sebastian, Heller, Maren K., Hobert, Markus A., Hofmann, Marc, Jemlich, Björn, Kerkmann, Laura, Knüpfer, Stephanie, Krause, Katharina, Kress, Maximilian, Krupp, Sonja, Kudelka, Jennifer, Kuhlenbäumer, Gregor, Kurth, Roland, Leypoldt, Frank, Maetzler, Corinna, Maia, Luis F., Moewius, Andreas, Neumann, Patricia, Niemann, Katharina, Ortlieb, Christian T., Paschen, Steffen, Pham, Hoang Minh, Puehler, Thomas, Radloff, Franziska, Riedel, Christian, Rogalski, Marten, Sablowsky, Simone, Schanz, Elena M., Schebesta, Linda, Schicketmüller, Andreas, Studt, Simone, Thieves, Martina, Tönges, Lars, Ullrich, Sebastian, Urban, Peter P., Vila-Chã, Nuno, Wiegard, Anna, Warmerdam, Elke, Warnecke, Tobias, Weiß, Michael, Welzel, Julius, Hansen, Clint, and Maetzler, Walter

Subjects
article, ddc:6, Balance, Body-worn sensors, Wearables, Comprehensive geriatric assessment, Executive function, Gait, Older adults, Quantitative assessment, ddc:610
Abstract

Background: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). Methods: This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. Diskussion: This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.

Published
2020

273. Tapentadol prevents motor impairments in a mouse model of dyskinesia

Author

Vaz, Rita, Chapela Pires, Diana, Coelho, Joana E, Lopes, Luisa V., Ferreira, Joaquim J, Afonso, Nuno D., Sousa, Sara, Outeiro, Tiago, and Repositório da Universidade de Lisboa

Subjects
Tapentadol, Mouse, Parkinson’s disease, Levodopa-induced dyskinesia, Norepinephrine reuptake inhibitor, µ-opioid receptor agonist
Abstract

© 2019 IBRO. Published by Elsevier Ltd. All rights reserved., The motor features in Parkinson's disease (PD) are associated with the degeneration of dopaminergic cells in the substantia nigra in the brain. Thus, the gold-standard in PD therapeutics still consists of dopamine replacement with levodopa. However, as the disease progresses, this therapeutic option becomes less effective and can be accompanied by levodopa-induced complications. On the other hand, several other neuronal pathways have been implicated in the pathological mechanisms of PD. In this context, the development of alternative therapeutic options that modulate non-dopaminergic targets is emerging as a major goal in the field. In a phenotypic-based screen in a zebrafish model of PD, we identified tapentadol as a candidate molecule for PD. The therapeutic potential of an agent that modulates the opioid and noradrenergic systems has not been explored, despite the implication of both neuronal pathways in parkinsonism. Therefore, we assessed the therapeutic properties of this µ-opioid receptor agonist and norepinephrine reuptake inhibitor in the 6-hydroxydopamine mouse model of parkinsonism. We further submitted 6-hydroxydopamine-lesioned mice to chronic treatment with levodopa and evaluated the effects of tapentadol during levodopa OFF states and on levodopa-induced dyskinesia. Importantly, we found that tapentadol halted the aggravation of dyskinesia and improved the motor impairments during levodopa OFF states. Altogether, our findings raise the hypothesis that concomitant modulation of µ-opioid receptor and norepinephrine transporter might constitute relevant intervention strategies in PD and that tapentadol holds therapeutic potential that may be translated into the clinical practice., This study was sponsored by TechnoPhage S.A. and Eurostars program (ES#5553) from EUREKA (a program run by the European Commission). Rita L. Vaz was supported by a grant (SFRH/BD/78077/2011) from Fundação para a Ciência e Tecnologia. Tiago F. Outeiro was supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB).

Published
2020

274. A critique of the fragility index

Author

Machado, Tiago, Duarte, Gonçalo Silva, Gonçalves, Nilza C., Ferreira, Joaquim J., Costa, João, and Repositório da Universidade de Lisboa

Abstract

Copyright © 2019 Elsevier B.V. or its licensors or contributors., In The Lancet Oncology , Joseph Del Paggio and Ian Tannock report on a retrospective analysis of the fragility indices of phase 3 trials used by the US Food and Drug Administration (FDA) to approve anticancer drugs. 1 The authors conclude that “many phase 3 randomised controlled trials supporting FDA-approved anticancer drugs have a low fragility index, challenging confidence for concluding their superiority over control treatments.” Although this interpretation is interesting, we would like to draw attention to several points.

Published
2019

277. Potential drug‐drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission.

Author

Mainoli, Beatrice, Gonçalves, Nilza, Ferreira, Joaquim J., and Mégarbane, Bruno

Subjects
SELF-poisoning, DRUG interactions, INTENSIVE care units, DISEASE risk factors, HOSPITAL admission & discharge, POISONING
Abstract

Beyond the direct toxicity resulting from each drug in the poisoned patient, additional toxicities may result from drug‐drug interactions (DDIs). We aimed to determine the frequency of potential DDIs in the poisoned patient and investigate whether DDIs are associated with severity. We conducted a 1‐year cohort study in a toxicological ICU. DDIs were identified using an electronic interaction‐checker tool. Among our 354 ICU poisoned patients, 134 (38%) presented at least one potential DDI between acute poisoning drugs and 180 (51%) at least one potential DDI between acute poisoning and long‐term treatment drugs. Using multivariate analyses, previous suicide attempt was associated with the presence of potential DDIs between acute poisoning drugs in suicide attempt patients (P = 0.014). Chronic alcoholism (P = 0.005) and tobacco smoking (P = 0.022) were associated with the presence of potential DDIs between acute poisoning and long‐term treatment drugs in recreational drug users. Presence of potential DDIs between acute poisoning and long‐term treatment drugs was associated with catecholamine infusion (P = 0.022) in suicidal self‐exposure patients. Presence of potential pharmacodynamic DDIs between acute poisoning and long‐term treatment drugs was associated with aspiration pneumonia onset in recreational drug users (P = 0.03). ICU poisoned patients present a high rate of potential DDIs that may influence the outcome. [ABSTRACT FROM AUTHOR]

Published
2022
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278. An MDS Evidence‐Based Review on Treatments for Huntington's Disease.

Author

Ferreira, Joaquim J., Rodrigues, Filipe B., Duarte, Gonçalo S., Mestre, Tiago A., Bachoud‐Levi, Anne‐Catherine, Bentivoglio, Anna Rita, Burgunder, Jean‐Marc, Cardoso, Francisco, Claassen, Daniel O., Landwehrmeyer, G. Bernard, Kulisevsky, Jaime, Nirenberg, Melissa J., Rosser, Anne, Roth, Jan, Seppi, Klaus, Slawek, Jaroslaw, Furr‐Stimming, Erin, Tabrizi, Sarah J., Walker, Francis O., and Vandenberghe, Wim

Abstract

Background: Huntington's disease (HD) is a rare neurodegenerative disorder with protean clinical manifestations. Its management is challenging, consisting mainly of off‐label treatments. Objectives: The International Parkinson and Movement Disorder Society commissioned a task force to review and evaluate the evidence of available therapies for HD gene expansion carriers. Methods: We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Eligible randomized controlled trials were identified via an electronic search of the CENTRAL, MEDLINE, and EMBASE databases. All eligible trials that evaluated one or more of 33 predetermined clinical questions were included. Risk of bias was evaluated using the Cochrane Risk of Bias tool. A framework was adapted to allow for efficacy and safety conclusions to be drawn from the balance between the GRADE level of evidence and the importance of the benefit/harm of the intervention. Results: Twenty‐two eligible studies involving 17 interventions were included, providing data to address 8 clinical questions. These data supported a likely effect of deutetrabenazine on motor impairment, chorea, and dystonia and of tetrabenazine on chorea. The data did not support a disease‐modifying effect for premanifest and manifest HD. There was no eligible evidence to support the use of specific treatments for depression, psychosis, irritability, apathy, or suicidality. Similarly, no evidence was eligible to support the use of physiotherapy, occupational therapy, exercise, dietary, or surgical treatments. Conclusions: Data for therapeutic interventions in HD are limited and support only the use of VMAT2 inhibitors for specific motor symptoms. © 2021 International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR]

Published
2022
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279. Frequency and Characteristics of Psychosis in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Author

Chendo, Ines, Silva, Carlos, Duarte, Gonçalo S., Prada, Luisa, Voon, Valerie, and Ferreira, Joaquim J.

Subjects
PARKINSON'S disease, PSYCHOSES, MOVEMENT disorders, HALLUCINATIONS, PATIENTS' attitudes, DISEASE duration
Abstract

Background: Psychotic symptoms are highly frequent in Parkinson's disease (PD) patients and are associated with poor prognosis. They include hallucinations, delusions, and minor psychotic phenomena, including sense of presence, passage hallucinations, and illusions. Objective: To evaluate the frequency of psychosis in PD patients. Methods: A systematic review and meta-analysis of clinical trials, prospective and retrospective cohort studies, case-control studies, and cross-sectional studies reporting the frequency of psychosis, hallucinations, and delusions in PD. Results: Electronic database search wielded 3536 articles, an additional 91 were identified through citation chaining. Of these, 163 were fully inspected, 57 removed, and 106 included as relevant for neuropsychiatric events frequency, with 32 meeting our inclusion criteria (psychosis and/or specific psychotic phenomena). The pooled frequency of psychosis was 20.7% (95% CI 14.5 to 28.6; I2 = 94%, 15 studies; combined n = 2919). None of the pre-defined meta-regressions or subgroup analyses were statistically significant or helped explain the statistical heterogeneity. The pooled frequency of any form of hallucination was 21.6% (95% CI 14.7 to 30.6; I2 = 95%; 18 studies; combined n = 3161). Duration of PD at baseline and mean baseline Hoehn & Yahr stage helped explain the statistical heterogeneity in the meta-analysis of hallucinations. Conclusion: Based on the available evidence, around a fifth of PD patients experience psychosis or hallucinations. The risk of developing hallucinations is likely moderated by the disease duration, Hoehn & Yahr stage, and the cognitive status. [ABSTRACT FROM AUTHOR]

Published
2022
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280. Caregiver Burden in Late-Stage Parkinsonism and Its Associations.

Author

Kalampokini, Stefania, Hommel, Adrianus L. A. J., Lorenzl, Stefan, Ferreira, Joaquim J., Meissner, Wassilios G., Odin, Per, Bloem, Bastiaan R., Dodel, Richard, and Schrag, Anette-Eleonore

Subjects
BURDEN of care, APATHY, PARKINSONIAN disorders, NON-communicable diseases, CAREGIVERS, SOCIAL impact, ACTIVITIES of daily living
Abstract

Background: Patients in the late stages of parkinsonism are highly dependent on others in their self-care and activities of daily living. However, few studies have assessed the physical, psychological and social consequences of caring for a person with late-stage parkinsonism.Patients and Methods: Five hundred and six patients and their caregivers from the Care of Late Stage Parkinsonism (CLaSP) study were included. Patients' motor and non-motor symptoms were assessed using the UPDRS and Non-motor symptom scale (NMSS), Neuropsychiatric inventory (NPI-12), and caregivers' health status using the EQ-5D-3 L. Caregiver burden was assessed by the Zarit Burden Interview (ZBI).Results: The majority of caregivers were the spouse or life partner (71.2%), and were living with the patient at home (67%). Approximately half of caregivers reported anxiety/depression and pain/discomfort (45% and 59% respectively). The factors most strongly associated with caregiver burden were patients' neuropsychiatric features on the total NPI score (r = 0.38, p < 0.0001), total NMSS score (r = 0.28, p < 0.0001), caring for male patients and patients living at home. Being the spouse, the hours per day assisting and supervising the patient as well as caregivers' EQ-5D mood and pain scores were also associated with higher ZBI scores (all p < 0.001).Conclusion: The care of patients with late stage parkinsonism is associated with significant caregiver burden, particularly when patients manifest many neuropsychiatric and non-motor features and when caring for a male patient at home. [ABSTRACT FROM AUTHOR]

Published
2022
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281. Cross-cultural adaptation and validation of the Swallowing Disturbance Questionnaire and the Sialorrhea Clinical Scale in Portuguese patients with Parkinson's disease.

Author

Cardoso, Ana Rita, Guimarães, Isabel, Santos, Helena, Carvalho, Joana, Abreu, Daisy, Gonçalves, Nilza, and Ferreira, Joaquim J.

Subjects
RESEARCH evaluation, DEGLUTITION, CONFIDENCE intervals, RESEARCH methodology evaluation, RESEARCH methodology, SELF-evaluation, HEALTH outcome assessment, DEGLUTITION disorders, DROOLING, COMPARATIVE studies, MULTITRAIT multimethod techniques, QUESTIONNAIRES, PARKINSON'S disease, DESCRIPTIVE statistics, FACTOR analysis, STATISTICAL correlation, DATA analysis software, RECEIVER operating characteristic curves, EVALUATION, SYMPTOMS
Abstract

To date, no valid outcome measure has been developed in European Portuguese (EP) to evaluate the Parkinsons' Disease (PD) patients' (PwP) reports regarding their swallowing disturbances. The aim of this study was to translate and cross-culturally adapt the Swallowing Disturbance Questionnaire (SDQ) and the Sialorrhea Clinical Scale for PD (SCS-PD) into EP and to determine its clinimetric properties in PwP. The original English SDQ and SCS-PD versions were cross-culturally adapted following recommendations established in international guidelines. The validation process involved 75 PwP and 65 healthy sex- and age-matched participants. The EP versions of the SDQ and SCS-PD are equivalent to the original versions (content, depth, and scoring). Statistical analyses for the SDQ tool revealed good feasibility (missing data <5%), acceptability (no floor or ceiling effects), excellent internal consistency (Cronbach´s α = 0.95), good construct validity (78.5% revealed large to moderate loadings), moderate convergent validity (r = 0.60), good divergent validity (r = 0.40), good known-groups validity (p-value <.05) and a fair sensitivity and specificity (AUC = 0.700). Statistical analyses for the SCS-PD tool shows good feasibility, reasonable acceptability (floor effect), good internal consistency (Cronbach´s α = 0.85), good construct validity (85.7% showed between large to moderate loadings), good convergent validity (r = 0.78), good divergent validity (r = 0.39), good known groups validity (p-value <.05) and a fair sensitivity and specificity (AUC = 0.704). The EP versions of the SDQ and SCS-PD maintained the characteristics of the original versions and therefore consistent tools to be used in PwP. [ABSTRACT FROM AUTHOR]

Published
2021
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282. Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Author

Mcnulty, Paul, Pilcher, Richard, Ramesh, Raviram, Necuiniate, Renata, Hughes, Alis, Farewell, Daniel, Holmans, Peter, Jones, Lesley, Bonelli, Raphael M., Hecht, Karen, Herranhof, Brigitte, Holl, Anna, Kapfhammer, Hans-Peter, Koppitz, Michael, Lilek, Sabine, Magnet, Markus, Müller, Nicole, Otti, Daniela, Painold, Annamaria, Reisinger, Karin, Scheibl, Monika, Schöggl, Helmut, Ullah, Jasmin, Braunwarth, Eva-Maria, Brugger, Florian, Buratti, Lisa, Hametner, Eva-Maria, Hepperger, Caroline, Holas, Christiane, Hotter, Anna, Hussl, Anna, Larcher, Barbara, Mahlknecht, Philipp, Müller, Christoph, Pinter, Bernadette, Poewe, Werner, Reiter, Eva-Magdalena, Seppi, Klaus, Sprenger, Fabienne, Wenning, Gregor, Ladurner, Gunther, Lilek, Stefan, Sinadinosa, Daniela, Staffen, Wolfgang, Walleczek, Anna Maria, Constant, Eric, Gillardin, Anne-Françoise, Léonard, Marie-Claude, Verellen-Dumoulin, Christine, Van De Wyngaerde, Françoise, Dupuis, Michel, Minet, Cécile, Ribaï, Pascale, Van Paemel, Dominique, Boogaerts, Andrea, Vandenberghe, Wim, Van Reijen, Dimphna, Kaiserova, Michaela, Šenkárová, Zuzana, Klempíř, Jiří, Majerová, Veronika, Roth, Jan, Madsen, Louise Hasselstrøm, Møller, Anette Torvin, Hjermind, Lena, Jacobsen, Oda, Lindquist, Suzanne, Nielsen, Jørgen, Regeur, Lisbeth, Stockholm, Jette, Larsen, Ida Unmack, Vangsted-Hansen, Christina, Vinther-Jensen, Tua, Lolk, Annette, Lundsgaard, Marianne, Wermuth, Lene, Andersson, Christian, Nyberg, Clara, Sundblom, Jimmy, Peippo, Maarit, Sipponen, Marjett, Hartikainen, Paivi, Ollokainen, Mari, Åman, Jaana, Ignatius, Jaakko, Kärppä, Mikko, Mustonen, Aki, Kajula, Outi, Jääskalainen, Outi, Moilanen, Jukka, Santala, Maire, Eklund, Pia, Hiivola, Heli, Hyppönen, Hannele, Martikainen, Kirsti, Tuuha, Katri, Allain, Philippe, Bonneau, Dominique, Bost, Marie, Gohier, Bénédicte, Guérid, Marie-Anne, Olivier, Audrey, Prouzet, Julie, Prundean, Adriana, Scherer-Gagou, Clarisse, Verny, Christophe, Babiloni, Blandine, Debruxelles, Sabrina, Duché, Charlotte, Goizet, Cyril, Jameau, Laetitia, Lafoucrière, Danielle, Spampinato, Umberto, Couttier, Julien, Debilly, Bérengère, Delaigue, Christine, Durif, Franck, Legendre, Perrine, Loiseau, Sylvie, Ulla, Miguel, Vidal, Tiphaine, Bachoud-Lévi, Anne-Catherine, Badei, Farideh, Boissé, Marie-Françoise, Boudali, Lotfi, De Langavant, Laurent Cleret, Lemoine, Laurie, Morgado, Graca, Youssov, Katia, Annic, Agnès, Barthélémy, Recka, De Bruycker, Christelle, Cabaret, Maryline, Carette, Anne-Sophie, Carrière, Nicolas, Decorte, Eric, Defebvre, Luc, Delliaux, Marie, Delval, Arnaud, Depelchin, Alizé, Destee, Alain, Dewulf-Pasz, Nelly, Dondaine, Thibaut, Dugauquier, Florence, Dujardin, Kathy, Hopes, Lucie, Krystkowiak, Pierre, Lemaire, Marie-Hélène, Manouvrier, Sylvie, Mutez, Eugénie, Peter, Mireille, Plomhause, Lucie, Sablonnière, Bernard, Simonin, Clémence, Tard, Céline, Thibault-Tanchou, Stéphanie, Vuillaume, Isabelle, Bellonet, Marcellin, Benoit, Alexandra, Berrisoul, Hassan, Blin, Stéphanie, Courtin, Françoise, Duru, Cécile, Fasquel, Véronique, Flament, Mélanie, Godefroy, Olivier, Mantaux, Béatrice, Playe, Alicia, Roussel, Martine, Tir, Mélissa, Schüler, Béatrice, Wannepain, Sandrine, Azulay, Jean-Philippe, Chabot, Christelle, Delfini, Marie, Eusebio, Alexandre, Fluchere, Frédérique, Grosjean, Hélène, Mundler, Laura, Nowak, Marielle, Raseta, Rolland, Benaich, Sandra, Brice, Alexis, Charles, Perrine, Durr, Alexandra, Ewenczyk, Claire, Francisque, Hélène, Jauffret, Céline, Justo, Damian, Kassar, Abdulrahman, Klebe, Stephan, Lesne, Fabien, Milani, Paolo, Monin, Marie-Lorraine, Roze, Emmanuel, Tataru, Alina, Tchikviladzé, Maya, Bioux, Sandrine, Bliaux, Evangeline, Girard, Carole, Guyant-Maréchal, Lucie, Hannequin, Didier, Hannier, Véronique, Jourdain, Séverine, Maltête, David, Pouliquen, Dorothée, Lagha-Boukbiza, Ouhaid, Longato, Nadine, Marcel, Christophe, Phillipps, Clélie, Rudolf, Gabrielle, Steinmetz, Giséle, Tranchant, Christine, Wagner, Caroline, Zimmermann, Marie-Agathe, Blondeau, Leily, Calvas, Fabienne, Cheriet, Samia, Delabaere, Helène, Demonet, Jean-François, Pariente, Jérémie, Pierre, Michèle, Rolland, Sandrine, Kosinski, Christoph Michael, Milkereit, Eva, Probst, Daniela, Reetz, Kathrin, Sass, Christian, Schiefer, Johannes, Schlangen, Christiane, Werner, Cornelius J., Beuth, Markus, Gelderblom, Harald, Priller, Josef, Prüß, Harald, Spruth, Eike, Thiel, Silvia, Andrich, Jürgen, Ellrichmann, Gisa, Herrmann, Lennard, Hoffmann, Rainer, Kaminski, Barbara, Kraus, Peter, Saft, Carsten, Stamm, Christiane, Lange, Herwig, Maiwald, Robert, Bosredon, Cecile, Hunger, Ulrike, Löhle, Matthias, Maass, Antonia, Ossig, Christiana, Schmidt, Simone, Storch, Alexander, Wolz, Annett, Wolz, Martin, Kohl, Zacharias, Kozay, Christina, Winkler, Jürgen, Bergmann, Ulrike, Böringer, Regina, Capetian, Philipp, Kammel, Gerit, Lambeck, Johann, Mächtel, Miriam, Meier, Simone, Rijntjes, Michel, Zucker, Birgit, Boelmans, Kai, Ganos, Christos, Goerendt, Ines, Heinicke, Walburgis, Hidding, Ute, Lewerenz, Jan, Münchau, Alexander, Orth, Michael, Schmalfeld, Jenny, Stubbe, Lars, Zittel, Simone, Diercks, Gabriele, Dressler, Dirk, Francis, Flverly, Gayde-Stephan, Sabine, Gorzolla, Heike, Kramer, Bianca, Minschke, Rebecca, Schrader, Christoph, Tacik, Pawel, Ribbat, Michael, Longinus, Bernhard, Lüsebrink, Antje, Mühlau, Mark, Peinemann, Alexander, Städtler, Michael, Weindl, Adolf, Winkelmann, Juliane, Ziegler, Cornelia, Bechtel, Natalie, Beckmann, Heike, Bohlen, Stefan, Göpfert, Nicole, Hölzner, Eva, Reilmann, Ralf, Rohm, Stefanie, Rumpf, Silke, Schepers, Sigrun, Weber, Nathalia, Bachmeier, Michael, Dose, Matthias, Hofstetter, Nina, Marquard, Ralf, Mühlbäck, Alzbeta, Barth, Katrin, Buck, Andrea, Connemann, Julia, Ecker, Daniel, Geitner, Carolin, Held, Christine, Kesse, Andrea, Landwehrmeyer, Bernhard, Lezius, Franziska, Nepper, Solveig, Niess, Anke, Schneider, Ariane, Schwenk, Daniela, Süssmuth, Sigurd, Trautmann, Sonja, Vogel, Melanie, Weydt, Patrick, Musacchio, Thomas, Leypold, Christine, Nöth, Kerstin, Cormio, Claudia, Difruscolo, Olimpia, Franco, Giovanni, Sciruicchio, Vittorio, Serpino, Claudia, De Tommaso, Marina, Calandra-Buonaura, Giovanna, Capellari, Sabina, Cortelli, Pietro, Gallassi, Roberto, Poda, Roberto, Scaglione, Cesa, Bertini, Elisabetta, Ghelli, Elena, Ginestroni, Andrea, Mechi, Claudia, Paganini, Marco, Piacentini, Silvia, Pradella, Silvia, Romoli, Anna Maria, Sorbi, Sandro, Abbruzzese, Giovanni, DI Poggio, Monica Bandettini, Ferrandes, Giovanna, Mandich, Paola, Marchese, Roberta, DI Maria, Emilio, Albanese, Alberto, Castagliuolo, Simona, Castaldo, Anna, DI Donato, Stefano, DI Bella, Daniela, Gellera, Cinzia, Genitrini, Silvia, Mariotti, Caterina, Monza, Daniela, Nanetti, Lorenzo, Panzeri, Marta, Paridi, Dominga, Soliveri, Paola, Spagnolo, Francesca, Taroni, Franco, Tomasello, Chiara, De Michele, Giuseppe, DI Maio, Luigi, Rinaldi, Carlo, Massarelli, Marco, Peluso, Silvio, Roca, Alessandro, Russo, Cinzia 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Franco, Giovanni, Sciruicchio, Vittorio, Serpino, Claudia, De Tommaso, Marina, Calandra-Buonaura, Giovanna, Capellari, Sabina, Cortelli, Pietro, Gallassi, Roberto, Poda, Roberto, Scaglione, Cesa, Bertini, Elisabetta, Ghelli, Elena, Ginestroni, Andrea, Mechi, Claudia, Paganini, Marco, Piacentini, Silvia, Pradella, Silvia, Romoli, Anna Maria, Sorbi, Sandro, Abbruzzese, Giovanni, DI Poggio, Monica Bandettini, Ferrandes, Giovanna, Mandich, Paola, Marchese, Roberta, DI Maria, Emilio, Albanese, Alberto, Castagliuolo, Simona, Castaldo, Anna, DI Donato, Stefano, DI Bella, Daniela, Gellera, Cinzia, Genitrini, Silvia, Mariotti, Caterina, Monza, Daniela, Nanetti, Lorenzo, Panzeri, Marta, Paridi, Dominga, Soliveri, Paola, Spagnolo, Francesca, Taroni, Franco, Tomasello, Chiara, De Michele, Giuseppe, DI Maio, Luigi, Rinaldi, Carlo, Massarelli, Marco, Peluso, Silvio, Roca, Alessandro, Russo, Cinzia Valeria, Salvatore, Elena, Sorrentino, Pierpaolo, Tucci, Tecla, Cannella, Milena, Codella, Valentina, De Gregorio, Francesca, De Nicola, Annunziata, Elifani, Francesca, Martino, Tiziana, Mazzante, Irene, Petrollini, Martina, Simonelli, Maria, Vezza, Maurizio, Squitieri, Ferdinando, Lovo, Francesca, Bentivoglio, Anna Rita, Bove, Francesco, Catalli, Claudio, DI Giacopo, Raffaella, Fasano, Alfonso, Frontali, Marina, Guidubaldi, Arianna, Ialongo, Tamara, Jacopini, Gioia, Loria, Giovanna, Modoni, Anna, Petracca, Martina, Piano, Carla, Piccininni, Chiara, Quaranta, Davide, Romano, Silvia, Soleti, Francesco, Solito, Marcella, Spadaro, Maria, Torlizzi, Flavia, Zinzi, Paola, Coarelli, Giulia, Ferraldeschi, Michela, Ristori, Giovanni, Van Hout, Monique S.E., Van Vugt, Jeroen P.P., De Weert, A. Marit, Verhoeven, Marloe, Dekker, Meike, Leenders, Nico, Van Oostrom, Joost, Klooster, Jesper, Kremer, Berry, Baake, Verena, Van Den Bogaard, Simon J.A., Bos, Reineke, Dumas, Eve M., Hart't, Ellen P., Kampstra, Anne, Roos, Raymund A.C., Schoonderbeek, Anne, Duits, Annelien, Oosterloo, Mayke, Waber, Mirella, Verstappen, Carla, Blinkenberg, Ellen Økland, Hauge, Erik, Tyvoll, Hilde, Aaserud, Olaf, Bjørgo, Kathrine, Borgeød, Nancy, Dramstad, Elisabeth, Fannemel, Madeleine, Frich, Jan C., Gørvell, Per F., Heiberg, Arvid, Retterstøl, Lar, Røsby, Oddveig, Sikiric, Alma, Stokke, Bodil, Van Walsem, Marleen, Wehus, Ragnhild, Bjørnevoll, Inga, Sando, Sigrid Botne, Haug, Marte Gjøl, Størseth, Hanna Haugan, Arntsen, Vibeke, Dziadkiewicz, Artur, Nowak, Malgorzata, Robowski, Piotr, Sitek, Emilia, Slawek, Jaroslaw, Soltan, Witold, Szinwelski, Michal, Arkuszewski, Michal, Blaszczyk, Magdalena, Boczarska-Jedynak, Magdalena, Ciach-Wysocka, Ewelina, Gorzkowska, Agnieszka, Jasińska-Myga, Barbara, Kaczmarczyk, Aleksandra, Klodowska-Duda, Gabriela, Opala, Grzegorz, Stompel, Daniel, Banaszkiewicz, Krzysztof, Boćwińska, Dorota, Bojakowska-Jaremek, Kamila, Dec, Malgorzata, Grabska, Natalia, Krawczyk, Malgorzata, Kubowicz, Ewelina, Malec-Litwinowicz, Michalina, Rudzińska, Monika, Stenwak, Agata, Szczudlik, Andrzej, Szczygiel, Elzbieta, Wójcik, Magdalena, Wasielewska, Anna, Aniola, Jacek, Bryl, Anna, Ciesielska, Anna, Klimberg, Aneta, Marcinkowski, Jerzy, Samara, Husam, Sempolowicz, Justyna, Wiśniewski, Bartlomiej, Zielonka, Daniel, Gogol, Anna, Janik, Piotr, Jamrozik, Zygmunt, Kaminska, Anna, Kwiecinski, Hubert, Antczak, Jakub, Jachinska, Katarzyna, Krysa, Wioletta, Rakowicz, Maryla, Richter, Przemyslaw, Rola, Rafal, Ryglewicz, Danuta, Sienkiewicz-Jarosz, Halina, Stȩpniak, Iwona, Sulek, Anna, Witkowski, Grzegorz, Zaremba, Jacek, Zdzienicka, Elzbieta, Ziora-Jakutowicz, Karolina, Januário, Cristina, Júlio, Filipa, Almeida, Manuel, Calado, Ana, DIas, Margarida, Morgado, Joana, Semedo, Cristina, Guedes, Leonor Correia, Coelho, Miguel, Ferreira, Joaquim J, Mestre, Tiago, Mendes, Tiago, Valadas, Anabela, Costa, Cristina, Cardoso, Helena, Andrade, Carlo, Costa, Andreia, Garrett, Carolina, Gago, Miguel, Guimarães, Joana, Massano, João, Meireles, Joana, Monteiro, Ana, Herrera, Carmen Durán, Moreno, Patrocinio Garcia, Bas, Jordi, Busquets, Núria, Calopa, Matilde, Classen, Serge Jaumá, Dedichá, Nadia Rodríguez, Buongiorno, María Teresa, De La Cerda Santa María, André, Muñoz, Esteban, Santacruz, Pilar, Barbera, Miquel Aguilar, Sebastián, Ana Rojo, Pardo, Sonia Arriba, Guia, Dolors Badene, Calzado, Noemi, Hernanz, Laura Casa, DÍaz-Zorita, Juan Pablo Tartari, Catena, Judit López, Ferrer, Pilar Quiléz, Carruesco, Gemma Tome, Robert, Misericordia Floriach, Viladrich, Cèlia Mareca, Roca, Elvira, Idiago, Jesús Miguel Ruiz, Villa Riballo, Antonio, Campolongo, Antonia, De Bobadilla, Ramon Fernandez, Bojarsky, Jaime Kulisevsky, Martinez-Horta, Saul, Pagonabarraga, Javier, Perez, Jesus Perez, Ribosa, Roser, Villa, Carolina, Angeles, Maria, Gil, Acera, Corrales, Koldo Berganzo, Esteban, Juan Carlos Gomez, González, Amaia, Merino, Beatriz Tijero, Cubo, Esther, Polo, Cecilia Gil, Mariscal, Natividad, Romero, Sandra Gutierrez, Arbelo, José Matía, De Molina, Rocío Malo, Martín, Idaira, Periañez, Juan Manuel, Udaeta, Beatriz, Alonso-Frech, Fernando, Del Valle Loarte, María, Barrero, Francisco, Morales, Bla, Frades, Belén, Villanueva, Marina Ávila, Sevilla, Maria Ascension Zea, Frech, Fernando Alonso, Del Mar Fenollar, María, García, Rocío García-Ramo, Villanueva, Clara, Garde, Mónica Bascuñana, Ventura, Marta Fatá, Caldentey, Juan García, Ribas, Guillermo García, De Yébenes, Justo García, Moreno, José Luis López-Sendón, Barral, Verónica Mañane, Cubillo, Patricia Trigo, Ruíz, Pedro José García, García, Ana, López, Rosa Guerrero, Bárcenas, Antonio Herranz, Martínez-Descals, Asunción, Martin, Veronica Puerta, Martínez, Noelia Rodríguez, Artiga, María José Sainz, Sánchez, Vicenta, Pueyo, Angel Martínez, Alarcón, Moreau María Dolore, Almagro, Carmen Antúnez, DIéguez, Esther, Fortuna, Lorenza, Manzanares, Salvadora, Muñoz, Juan Marín, Torres, María Martirio Antequera, Perea, Fuensanta Noguera, Vivancos, Laura, González, Sonia, Guisasola, Luis Menéndez, Prieto, Marta Para, Ribacoba, René, Salvador, Carlo, Lozano, Pablo Sánchez, Ramirez, Inés Legarda, Arques, Penelope Nava, Lopera, Monica Rodriguez, Pastor, Barbara Vive, Gaston, Itziar, Garcia-Amigot, Fermin, Martinez-Jaurrieta, Maria Dolore, Ramos-Arroyo, Maria Antonia, Carrillo, Fátima, Redondo, María Teresa Cácere, Mir, Pablo, González, Laura Varga, Hermoso, Fátima Dama, Moreno, Jose Manuel García, Lucena, Carolina Mendez, Cortegana, Eva María Pacheco, Peña, José Chacón, Redondo, Lui, Sánchez, Violeta Sánchez, Fernandez, Cristina Melgar, Lemos, María Dolores Romero, Mata, Maite Parede, Casado, Rocío Villagrán, Bosca, Maria, Burguera, Juan Andre, Brugada, Francisco Castera, Vilaplana, Carmen Peiró, Solís, Pilar, Figuerola, Begoña Jeweinat, Palanca, Paloma Millan, Wahlström, Jan, Høsterey-Ugander, Ulrika, Fredlund, Gunnel, Constantinescu, Radu, Neleborn-Lingefjärd, Liselotte, Berglund, Maria, Berglund, Peter, Linnsand, Petra, Björnsson, Elisabeth, Paucar, Martin, Pålhagen, Sven, Svenningsson, Per, Wallden, Tina, Loutfi, Ghada, Olofsson, Carina, Stattin, Eva-Lena, Westman, Laila, Wikström, Birgitta, Ekwall, Camilla, Göller, Marie-Lousie, Burgunder, Jean-Marc, Stebler, Yanik, Kaelin, Alain, Romero, Irene, Schüpbach, Michael, Zaugg, Sabine Weber, Esposito, Federica, Good, Jean-Marc, Paus, Karin, Vingerhoets, Francoi, Wider, Christian, Jung, Hans H., Petersen, Jens A., Ligon-Auer, Maria, Mihaylova, Violeta, Downie, Lorna, Jack, Roisin, Matheson, Kirsty, Miedzybrodzka, Zosia, Rae, Daniela, Simpson, Sheila A, Summers, Fiona, Ure, Alexandra, Vaughan, Vivien, Harrower, Timothy, Vernon, Nathan, Akhtar, Shahbana, Crooks, Jenny, Curtis, Adrienne, De Souza Keylock, Jenny, Rickards, Hugh, Wright, Jan, Coulthard, Elizabeth, Hayward, Beverley, Sieradzan, Kasia, Wright, Abigail, Barker, Roger A., O'Keefe, Deidre, DI Pietro, Anna Gerrtiz, Fisher, Kate, Goodman, Anna, Hill, Susan, Mason, Sarah, Swain, Rachel, Guzman, Natalie Valle, Busse, Monica, Butcher, Cynthia, Dunnett, Stephen, Clenaghan, Catherine, Fullam, Ruth, Hunt, Sarah, Jones, Una, Khalil, Hanan, Minster, Sara, Owen, Michael, Price, Kathleen, Townhill, Jenny, Rosser, Anne, Goudie, David, Buchanan, Lindsay, McFadyen, Paula, Tonner, Alison, Taylor, Anne-Marie, Edwards, Maureen, Ho, Carrie, McGill, Marie, Porteous, Mary, Pearson, Pauline, Irvine, Sarah, Brockie, Peter, Foster, Jillian, Johns, Nicola, McKenzie, Sue, Rothery, Jean, Thomas, Gareth, Yates, Shona, Deith, Catherine, Ireland, Jane, Ritchie, Stuart, Burrows, Liz, Fletcher, Amy, Harding, Alison, Laver, Fiona, Silva, Mark, Thomson, Aileen, Chu, Carol, Evans, Carole, Gallentree, Deena, Hamer, Stephanie, Kraus, Alison, Markova, Ivana, Raman, Ashok, Andrew, Alyson, Frost, Julie, Noad, Rupert, Hobson, Emma, Jamieson, Stuart, Longthorpe, Mandy, Musgrave, Hannah, Peacy, Caroline, Rowett, Liz, Toscano, Jean, Wild, Sue, Yardumian, Pam, Clayton, Carole, DIpple, Heather, Freire-Patino, Dawn, Hallam, Caroline, Middleton, Julia, Alusi, Sundu, Davies, Rhy, Foy, Kevin, Gerrans, Emily, Pate, Louise, Anjum, Uruj, Coebergh, Jan, Eddy, Charlotte, Lahiri, Nayana, McEntagart, Meriel, Patton, Michael, Peterson, Maria, Rose, Sarah, Andrews, Thomasin, Dougherty, Andrew, Golding, Charlotte, Kavalier, Fred, Laing, Hana, Lashwood, Alison, Robertson, Dene, Ruddy, Deborah, Santhouse, Alastair, Whaite, Anna, Bruno, Stefania, Chu, Elvina, Doherty, Karen, Haider, Salman, Hensman, Davina, Lewis, Monica, Novak, Marianne, Patel, Aakta, Robertson, Nicola, Rosser, Elisabeth, Tabrizi, Sarah, Taylor, Rachel, Warner, Thoma, Wild, Edward, Arran, Natalie, Bek, Judith, Callaghan, Jenny, Craufurd, David, Hare, Marianne, Howard, Liz, Huson, Susan, Johnson, Liz, Jones, Mary, Krishnamoorthy, Ashok, Murphy, Helen, Oughton, Emma, Partington-Jones, Lucy, Rogers, Dawn, Sollom, Andrea, Snowden, Julie, Stopford, Cheryl, Thompson, Jennifer, Trender-Gerhard, Iri, Verstraelen, Nicola, Westmoreland, Leann, Cass, Ginette, Davidson, Lynn, Davison, Jill, Komati, Suresh, McDonnell, Sharon, Mohammed, Zeid, Morgan, Karen, Savage, Loi, Singh, Baldev, Wood, Josh, Knight, Caroline, O'Neill, Mari, Das Purkayastha, Debasish, Nemeth, Andrea H, Siuda, Gill, Valentine, Ruth, Armstrong, Richard, Harrison, David, Hughes, Max, Large, Sandra, Donovan, John O, Palmer, Amy, Parkinson, Andrew, Soltysiak, Beverley, Timings, Leanne, Williams, Josh, Burn, John, Weekes, Rebecca, Craven, Janet, Bailey, Wendy, Coleman, Caroline, Haig-Brown, DIane, Simpson, Steve, Majeed, Tahir, Bandmann, Oliver, Bradbury, Alyson, Fairtlough, Helen, Fillingham, Kay, Foustanos, Isabella, Gill, Paul, Kazoka, Mbombe, O'Donovan, Kirsty, Nevitt, Louise, Peppa, Nadia, Quarrell, Oliver, Taylor, Cat, Tidswell, Katherine, Agarwal, Veena, Anderson, Mary, Gunner, Kerry, Harris, Kayla, Hayward, Elaine, Heywood, Melanie, Keys, Liane, MacKinnon, Lesley, Kipps, Christopher, Smalley, Sarah, Bethwaite, Pamela, Edwards, Rachel, Fuller, Kathleen, Gowers, Lesley, Phillips, Michelle, Powell, Kingsley, Biunno, Ida, Bronzova, Juliana, Giuliano, Joe, Handley, Olivia J., Illarioshkin, Sergey, Illmann, Torsten, Levey, Jamie, McLean, Tim, Koivisto, Susana Pro, Päivärinta, Markku, Uhrova, Tereza, Betz, Sabrina, Come, Adrien, Capodarca, Selene, Charpentier, Sébastien, Da Silva, Wildson Vieira, DI Renzo, Martina, Finisterra, Ana Maria, Genoves, Camille, Gilling, Mette, Hvalstedt, Carina, Koppers, Kerstin, Lamanna, Claudia, Laurá, Matilde, Münkel, Kristina, Mütze, Lisanne, Oehmen, Martin, Padieu, Helene, Paterski, Laurent, Rindal, Beate, Røren, Niini, Šašinková, Pavla, Seliverstov, Yury, Timewell, Erika, Witjes-Ané, Marie-Noelle, Yudina, Elizaveta, Zielonka, Eugeniusz, Mcnulty, Paul, Hannequin, Didier, Diercks, Gabriele, Dressler, Dirk, Difruscolo, Olimpia, Van Hout, Monique S. E., Van Vugt, Jeroen P. P., Van Den Bogaard, Simon J. A., Hart'T, Ellen P., Roos, Raymund A. C., Dias, Margarida, Diéguez, Esther, Mcfadyen, Paula, Mcgill, Marie, Mckenzie, Sue, Dipple, Heather, Mcentagart, Meriel, Mcdonnell, Sharon, Haig-Brown, Diane, Mackinnon, Lesley, and Mclean, Tim

Subjects
Adult, Male, Adolescent, Huntington's disease, cancer, neurodegeneration, trinucleotide repeat, Cellular and Molecular Neuroscience, Young Adult, Neoplasms, Trinucleotide repeat, Humans, Genetic Predisposition to Disease, Prospective Studies, Registries, Age of Onset, Neurodegeneration, Child, Aged, Cancer, Aged, 80 and over, Huntingtin Protein, Incidence, Infant, Newborn, Infant, Middle Aged, Europe, Settore MED/26 - NEUROLOGIA, Huntington Disease, Huntington’s disease, Child, Preschool, Female, Neurology (clinical), Trinucleotide Repeat Expansion
Abstract

Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis.

Published
2018
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284. Opicapone for the treatment of Parkinson’s disease

Author

Rodrigues, Filipe Brogueira, Ferreira, Joaquim J, and Repositório da Universidade de Lisboa

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Parkinson's disease, Dopamine, Disease, Catechol O-Methyltransferase, COMT inhibitor, Opicapone, Antiparkinson Agents, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Humans, Medicine, Pharmacology (medical), Pharmacology, Oxadiazoles, business.industry, Disease progression, Catechol O-Methyltransferase Inhibitors, Treatment options, Parkinson Disease, General Medicine, medicine.disease, Motor fluctuations, 030104 developmental biology, chemistry, Anesthesia, Parkinson’s disease, Disease Progression, business, 030217 neurology & neurosurgery
Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group, Parkinson's disease (PD) is a progressive neurodegenerative disease. The currently available treatment options only have a symptomatic effect. With disease progression almost all antiparkinsonian pharmacological classes are tried, but the gold standard of pharmacological management is still L-dopa. Various strategies can be used to raise the dopaminergic tone. Catechol-O-methyltransferase (COMT) inhibitors attain this goal by decreasing L-dopa peripheral metabolism. Areas covered: Opicapone (Ongentys®) is a new COMT inhibitor developed to fulfill the need for more potent, safer and longer acting COMT inhibitors. This review puts into context opicapone's indications, its chemical and preclinical data, the pharmacodynamics and pharmacokinetic characteristics, and the efficacy and safety results delivered by clinical trials. Expert opinion: Opicapone is an efficacious COMT inhibitor. Its proprieties make it adequate for a once-a-day oral dose regimen. It has proved to reduce the off-time and to increase the on-time without troublesome dyskinesias in PD patients with motor fluctuations. The reported adverse events suggest an overall safe and well-tolerated profile. The most common adverse events were dyskinesia, and there were no issues of concern for hepatotoxicity, severe diarrhoea or chromaturia. Further evidence is still needed to conclude how it compares with other drugs for the treatment of motor fluctuations.

Published
2017
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285. Feasibility and Safety of Telerehabilitation for Physiotherapy Interventions in Movement Disorders Patients.

Author

Caniça, Verónica, Bouça‐Machado, Raquel, Ferreira, Joaquim J., Guerreiro, Daniela, Nunes, Raquel, Nunes, Pedro, Queimado, Francisco, Saúde‐Braz, Alexandra, Leitão, Mariana, Lousada, Inês, Ferreira, Filipa Pona, Lobo, Teresa, Belo, João, Antunes, Laura, Alves, Joana, Cacho, Ricardo, Santos, Beatriz, Dias, Susana, Patriarca, Alexandra, and Costa, Patrícia

Subjects
TELEREHABILITATION, MOVEMENT disorders, PHYSICAL therapy, COVID-19, PATIENTS' attitudes, MEDICAL personnel
Abstract

This letter reports the results of a pragmatic feasibility study that evaluates the feasibility and safety of telerehabilitation physiotherapy sessions in patients with movement disorders. Telerehabilitation physiotherapy sessions have created opportunities for enhanced care, better self-management options for movement disorder patients, and overall improved healthcare. Keywords: movement disorders; telerehabilitation; physiotherapy EN movement disorders telerehabilitation physiotherapy 1144 1147 4 10/05/21 20211001 NES 211001 Several movement disorder patients were forced to stay in self-quarantine due to the current coronavirus disease 2019 (COVID-19) pandemic, interrupting their physiotherapy treatment.1,2 To overcome the negative effects of this sudden stop, video call systems started being used to perform physiotherapy sessions remotely (telerehabilitation). [Extracted from the article]

Published
2021
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286. Speech intelligibility of Parkinson's disease patients evaluated by different groups of healthcare professionals and naïve listeners.

Author

Carvalho, Joana, Cardoso, Rita, Guimarães, Isabel, and Ferreira, Joaquim J.

Subjects
WORK experience (Employment), SPEECH perception, DATABASES, KRUSKAL-Wallis Test, DYSARTHRIA, NEUROLOGISTS, INTELLIGIBILITY of speech, ATTITUDE (Psychology), CROSS-sectional method, MEDICAL personnel, SEVERITY of illness index, FAMILY attitudes, PATIENTS' attitudes, COMPARATIVE studies, PARKINSON'S disease, DESCRIPTIVE statistics, CHI-squared test, PEOPLE with disabilities, LISTENING, ACOUSTIC stimulation, STATISTICAL sampling, DATA analysis software, DISEASE complications
Abstract

Speech intelligibility, how well a listener comprehends the speaker's message, is related to the listener' expertise and type of the message conveyed. There is no evidence about speech intelligibility in different groups of healthcare professionals and naïve listeners. This study is the first to understand if there were differences in the speech intelligibility of Parkinson's Disease (PD) patients by different experienced and naïve listeners, according to the speech stimuli and dysarthria severity. Randomly digitised audio-files (50 words and 50 sentences) of 10 PD patients, one without dysarthria and 9 with different dysarthria severities (3 each: mild, moderate and severe dysarthria), were collected from a database of 60 PD patients' audio-files. A jury panel was formed by five different listeners groups including 10 speech and language therapists, 10 neurologists, 10 PD relatives, 12 PD patients, and 10 people from the general population. The jury panel transcribed single words and sentences from the audio recordings, the percentage correctly understood was calculated and the results were compared between the groups. Multiple comparisons showed significant speech intelligibility differences between healthcare professionals and naïve listerners in words (highest effect size, η2 = 0.7) and sentences (the highest effect size: η2 = 0.6). Pairwise comparisons revealed that those significant differences were specifically in words with moderate and severe dysarthria and sentences with all severity levels of dysarthria. The groups of healthcare professionals who work with dysarthria are more likely to understand the PD patients' speech than the groups of naïve listeners. [ABSTRACT FROM AUTHOR]

Published
2021
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287. LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

Author

Quadri, Marialuisa, primary, Mandemakers, Wim, additional, Grochowska, Martyna M, additional, Masius, Roy, additional, Geut, Hanneke, additional, Fabrizio, Edito, additional, Breedveld, Guido J, additional, Kuipers, Demy, additional, Minneboo, Michelle, additional, Vergouw, Leonie J M, additional, Carreras Mascaro, Ana, additional, Yonova-Doing, Ekaterina, additional, Simons, Erik, additional, Zhao, Tianna, additional, Di Fonzo, Alessio B, additional, Chang, Hsiu-Chen, additional, Parchi, Piero, additional, Melis, Marta, additional, Correia Guedes, Leonor, additional, Criscuolo, Chiara, additional, Thomas, Astrid, additional, Brouwer, Rutger W W, additional, Heijsman, Daphne, additional, Ingrassia, Angela M T, additional, Calandra Buonaura, Giovanna, additional, Rood, Janneke P, additional, Capellari, Sabina, additional, Rozemuller, Annemieke J, additional, Sarchioto, Marianna, additional, Fen Chien, Hsin, additional, Vanacore, Nicola, additional, Olgiati, Simone, additional, Wu-Chou, Yah-Huei, additional, Yeh, Tu-Hsueh, additional, Boon, Agnita J W, additional, Hoogers, Susanne E, additional, Ghazvini, Mehrnaz, additional, IJpma, Arne S, additional, van IJcken, Wilfred F J, additional, Onofrj, Marco, additional, Barone, Paolo, additional, Nicholl, David J, additional, Puschmann, Andreas, additional, De Mari, Michele, additional, Kievit, Anneke J, additional, Barbosa, Egberto, additional, De Michele, Giuseppe, additional, Majoor-Krakauer, Danielle, additional, van Swieten, John C, additional, de Jong, Frank J, additional, Ferreira, Joaquim J, additional, Cossu, Giovanni, additional, Lu, Chin-Song, additional, Meco, Giuseppe, additional, Cortelli, Pietro, additional, van de Berg, Wilma D J, additional, Bonifati, Vincenzo, additional, Quadri, Marialuisa, additional, Kievit, Anneke J.A., additional, Boon, Agnita J.W., additional, Rood, Janneke P.A, additional, Vergouw, Leonie J.M., additional, de Jong, Frank J., additional, van Swieten, John C., additional, Mattace-Raso, Francesco U.S., additional, Leenders, Klaus L., additional, Ferreira, Joaquim J., additional, Ygland, Emil, additional, Nilsson, Christer, additional, Chien, Hsin F., additional, Bannach Jardim, Laura, additional, Rieder, Carlos R.M., additional, Lopiano, Leonardo, additional, Tassorelli, Cristina, additional, Pacchetti, Claudio, additional, Riboldazzi, Giulio, additional, Bono, Giorgio, additional, Comi, Cristoforo, additional, Padovani, Alessandro, additional, Borroni, Barbara, additional, Raudino, Francesco, additional, Fincati, Emiliana, additional, Tinazzi, Michele, additional, Bonizzato, Alberto, additional, Ferracci, Carlo, additional, Dalla Libera, Alessio, additional, Abbruzzese, Giovanni, additional, Marconi, Roberto, additional, Guidi, Marco, additional, Fabbrini, Giovanni, additional, Berardelli, Alfredo, additional, Stocchi, Fabrizio, additional, Vacca, Laura, additional, Picillo, Marina, additional, Dell'Aquila, Claudia, additional, Iliceto, Gianni, additional, Toni, Vincenzo, additional, Trianni, Giorgio, additional, Gagliardi, Monica, additional, Annesi, Grazia, additional, Quattrone, Aldo, additional, Saddi, Valeria, additional, Cossu, Gianni, additional, and Melis, Maurizio, additional

Published
2018
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288. Long‐term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open‐label extensions

Author

Ferreira, Joaquim J, Lees, A., Rocha, J.‐F., Poewe, W., Rascol, O., Soares‐da‐Silva, P., and Repositório da Universidade de Lisboa

Subjects
Parkinson's disease, OFF time, Opicapone, Motor fluctuations
Abstract

© 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes., Background and purpose: The aim was to evaluate the efficacy of the catechol-O-methyltransferase inhibitor opicapone (25 and 50 mg) as adjunct therapy to levodopa in a pooled population of Parkinson's disease patients who participated in the pivotal double-blind trials of opicapone and their 1-year open-label extensions. Methods: Data (placebo, opicapone 25 mg and opicapone 50 mg) from the BIPARK-1 and BIPARK-2 double-blind and open-label studies were combined. The studies had similar designs, eligibility criteria and assessment methods. The primary efficacy variable in both double-blind studies was the change from baseline in absolute OFF time based on patient diaries. Results: Double-blind treatment with opicapone (25 and 50 mg) significantly reduced absolute daily OFF time from a baseline of 6.1-6.6 h. The mean (and 95% confidence interval) treatment effect versus placebo was -35.1 (-62.1, -8.2) min (P = 0.0106) for the 25 mg dose and -58.1 (-84.5, -31.7) min (P < 0.0001) for the 50 mg dose. Reductions in OFF time were mirrored by significant increases in ON time without troublesome dyskinesia (P < 0.05 and P < 0.0001 for the 25 and 50 mg doses, respectively). No significant differences were observed for ON time with troublesome dyskinesia. Patient diary results from the open-label phase indicated a maintenance of effect for patients previously treated with opicapone 50 mg. The group previously treated with the 25 mg dose benefitted with further optimization of therapy during the open-label phase, whilst switching from placebo to opicapone led to significant reductions in OFF time and increased ON time. Conclusions: Over at least 1 year of open-label therapy, opicapone consistently reduced OFF time and increased ON time without increasing the frequency of troublesome dyskinesia., The BIPARK-1 and BIPARK-2 studies were supported and funded by BIAL – Portela & Ca, S.A. Medical writing assistance was provided by A. Chadha-Patel and was funded by BIAL – Portela & Ca, S.A.

Published
2019

289. Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment – the ComOn-study

Author

Geritz, Johanna, primary, Maetzold, Sara, additional, Steffen, Maren, additional, Pilotto, Andrea, additional, Corrà, Marta F., additional, Moscovich, Mariana, additional, Rizzetti, Maria C., additional, Borroni, Barbara, additional, Padovani, Alessandro, additional, Alpes, Annekathrin, additional, Bang, Corinna, additional, Barcellos, Igor, additional, Baron, Ralf, additional, Bartsch, Thorsten, additional, Becktepe, Jos S., additional, Berg, Daniela, additional, Bergeest, Lu M., additional, Bergmann, Philipp, additional, Bouça-Machado, Raquel, additional, Drey, Michael, additional, Elshehabi, Morad, additional, Farahmandi, Susan, additional, Ferreira, Joaquim J., additional, Franke, Andre, additional, Friederich, Anja, additional, Geisler, Corinna, additional, Hüllemann, Philipp, additional, Gierthmühlen, Janne, additional, Granert, Oliver, additional, Heinzel, Sebastian, additional, Heller, Maren K., additional, Hobert, Markus A., additional, Hofmann, Marc, additional, Jemlich, Björn, additional, Kerkmann, Laura, additional, Knüpfer, Stephanie, additional, Krause, Katharina, additional, Kress, Maximilian, additional, Krupp, Sonja, additional, Kudelka, Jennifer, additional, Kuhlenbäumer, Gregor, additional, Kurth, Roland, additional, Leypoldt, Frank, additional, Maetzler, Corina, additional, Maia, Luis F., additional, Moewius, Andreas, additional, Neumann, Patricia, additional, Niemann, Katharina, additional, Ortlieb, Christian T., additional, Paschen, Steffen, additional, Pham, Minh H., additional, Puehler, Thomas, additional, Radloff, Franziska, additional, Riedel, Christian, additional, Rogalski, Marten, additional, Sablowsky, Simone, additional, Schanz, Elena M., additional, Schebesta, Linda, additional, Schicketmüller, Andreas, additional, Studt, Simone, additional, Thieves, Martina, additional, Tönges, Lars, additional, Ullrich, Sebastian, additional, Urban, Peter P., additional, Vila-Chã, Nuno, additional, Wiegard, Anna, additional, Warmerdam, Elke, additional, Warnecke, Tobias, additional, Weiss, Michael, additional, Welzel, Julius, additional, Hansen, Clint, additional, and Maetzler, Walter, additional

Published
2020
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291. Risk of Developing Parkinson Disease in Bipolar Disorder

Author

Faustino, Patrícia R., primary, Duarte, Gonçalo S., additional, Chendo, Inês, additional, Castro Caldas, Ana, additional, Reimão, Sofia, additional, Fernandes, Ricardo M., additional, Vale, José, additional, Tinazzi, Michele, additional, Bhatia, Kailash, additional, and Ferreira, Joaquim J., additional

Published
2020
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293. A systematic review

Author

Vaz, Rita L., Outeiro, Tiago F., Ferreira, Joaquim J., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Neurology, Drug discovery, Clinical Neurology, Hypokinesia, Movement disorders, Hyperkinesia, Zebrafish models
Abstract

The authors would like to thank Mariana Trigo Pereira, who kindly provided the pictures of zebrafish. RV was supported by a grant (SFRH/BD/78077/2011) from Fundação para e a Ciência e Tecnologia. TO is supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB). Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's disease (PD). By contrast, hyperkinetic syndromes encompass a broader array of diseases, including dystonia, essential tremor, or Huntington's disease. The discovery of effective therapies for these disorders has been challenging and has also involved the development and characterization of accurate animal models for the screening of new drugs. Zebrafish constitutes an alternative vertebrate model for the study of movement disorders. The neuronal circuitries involved in movement in zebrafish are well characterized, and most of the associated molecular mechanisms are highly conserved. Particularly, zebrafish models of PD have contributed to a better understanding of the role of several genes implicated in the disease. Furthermore, zebrafish is a vertebrate model particularly suited for large-scale drug screenings. The relatively small size of zebrafish, optical transparency, and lifecycle, are key characteristics that facilitate the study of multiple compounds at the same time. Several transgenic, knockdown, and mutant zebrafish lines have been generated and characterized. Therefore, it is central to critically analyze these zebrafish lines and understand their suitability as models of movement disorders. Here, we revise the pathogenic mechanisms, phenotypes, and responsiveness to pharmacotherapies of zebrafish lines of the most common movement disorders. A systematic review of the literature was conducted by including all studies reporting the characterization of zebrafish models of the movement disorders selected from five bibliographic databases. A total of 63 studies were analyzed, and the most relevant data within the scope of this review were gathered. The majority (62%) of the studies were focused in the characterization of zebrafish models of PD. Overall, the zebrafish models included display conserved biochemical and neurobehavioral features of the phenomenology in humans. Nevertheless, in light of what is known for all animal models available, the use of zebrafish as a model for drug discovery requires further optimization. Future technological developments alongside with a deeper understanding of the molecular bases of these disorders should enable the development of novel zebrafish lines that can prove useful for drug discovery for movement disorders. publishersversion published

Published
2018

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