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254. Vital Directions for Health and Health Care

Author

Dzau, Victor J., primary, McClellan, Mark B., additional, McGinnis, J. Michael, additional, Burke, Sheila P., additional, Coye, Molly J., additional, Diaz, Angela, additional, Daschle, Thomas A., additional, Frist, William H., additional, Gaines, Martha, additional, Hamburg, Margaret A., additional, Henney, Jane E., additional, Kumanyika, Shiriki, additional, Leavitt, Michael O., additional, Parker, Ruth M., additional, Sandy, Lewis G., additional, Schaeffer, Leonard D., additional, Steele, Glenn D., additional, Thompson, Pamela, additional, and Zerhouni, Elias, additional

Published
2017
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256. Sox6 as a new modulator of renin expression in the kidney.

Author

Saleem, Mohammad, Hodgkinson, Conrad P., Liang Xiao, Gimenez-Bastida, Juan A., Rasmussen, Megan L., Foss, Jason, Payne, Alan J., Mirotsou, Maria, Gama, Vivian, Dzau, Victor J., and Gomez, Jose A.

Abstract

Juxtaglomerular (JG) cells, major sources of renin, differentiate from metanephric mesenchymal cells that give rise to JG cells or a subset of smooth muscle cells of the renal afferent arteriole. During periods of dehydration and salt deprivation, renal mesenchymal stromal cells (MSCs) differentiate from JG cells. JG cells undergo expansion and smooth muscle cells redifferentiate to express renin along the afferent arteriole. Gene expression profiling comparing resident renal MSCs with JG cells indicates that the transcription factor Sox6 is highly expressed in JG cells in the adult kidney. In vitro, loss of Sox6 expression reduces differentiation of renal MSCs to renin-producing cells. In vivo, Sox6 expression is upregulated after a low-Na+ diet and furosemide. Importantly, knockout of Sox6 in Ren1d+ cells halts the increase in renin-expressing cells normally seen during a low-Na+ diet and furosemide as well as the typical increase in renin. Furthermore, Sox6 ablation in renin-expressing cells halts the recruitment of smooth muscle cells along the afferent arteriole, which normally express renin under these conditions. These results support a previously undefined role for Sox6 in renin expression. [ABSTRACT FROM AUTHOR]

Published
2020
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271. Preventing a Parallel Pandemic - A National Strategy to Protect Clinicians' Well-Being.

Author

Dzau, Victor J., Kirch, Darrell, and Nasca, Thomas

Subjects
*PANDEMICS, *GRAND strategy (Political science), *MEDICAL personnel, *COVID-19 pandemic, *WELL-being
Abstract

The article focuses on the working of national health care strategy towards preventing Covid-19 pandemic. It highlights facing a surge of physical and emotional harm that amounts to a parallel pandemic; also discusses an overwhelming numbers of seriously ill patients and shortages of essential supplies, with providing the optimal standard of care.

Published
2020
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273. Embed equity throughout innovation.

Author

Wailoo, Keith A., Dzau, Victor J., and Yamamoto, Keith R.

Subjects
*TECHNOLOGY assessment, *TECHNOLOGICAL innovations
Abstract

The authors argue on the need for the U.S. to rethink its innovation ecosystem and make sure to embed equity as a foundational guiding principle in order to realize the social benefit of technologies. Topics include the implications of innovation policies that only focus on profitable transitions of scientific breakthroughs, the steps and practices that equitable innovation requires, and federal initiatives that address equity in innovation.

Published
2023
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276. Global implementation of genomic medicine: We are not alone.

Author

Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) [research center], Manolio, Teri A., Abramowicz, Marc, Al-Mulla, Fahd, Anderson, Warwick, Balling, Rudi, Berger, Adam C., Bleyl, Steven, Chakravarti, Aravinda, Chantratita, Wasun, Chisholm, Rex L., Dissanayake, Vajira H. W., Dunn, Michael, Dzau, Victor J., Han, Bok-Ghee, Hubbard, Tim, Kolbe, Anne, Korf, Bruce, Kubo, Michiaki, Lasko, Paul, Leego, Erkki, Mahasirimongkol, Surakameth, Majumdar, Partha P., Matthijs, Gert, McLeod, Howard L., Metspalu, Andres, Meulien, Pierre, Miyano, Satoru, Naparstek, Yaakov, O'Rourke, P. Pearl, Patrinos, George P., Rehm, Heidi L., Relling, Mary V., Rennert, Gad, Rodriguez, Laura Lyman, Roden, Dan M., Shuldiner, Alan R., Sinha, Sukdeb, Tan, Patrick, Ulfendahl, Mats, Ward, Robyn, Williams, Marc S., Wong, John E. L., Green, Eric D., Ginsburg, Geoffrey S., Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) [research center], Manolio, Teri A., Abramowicz, Marc, Al-Mulla, Fahd, Anderson, Warwick, Balling, Rudi, Berger, Adam C., Bleyl, Steven, Chakravarti, Aravinda, Chantratita, Wasun, Chisholm, Rex L., Dissanayake, Vajira H. W., Dunn, Michael, Dzau, Victor J., Han, Bok-Ghee, Hubbard, Tim, Kolbe, Anne, Korf, Bruce, Kubo, Michiaki, Lasko, Paul, Leego, Erkki, Mahasirimongkol, Surakameth, Majumdar, Partha P., Matthijs, Gert, McLeod, Howard L., Metspalu, Andres, Meulien, Pierre, Miyano, Satoru, Naparstek, Yaakov, O'Rourke, P. Pearl, Patrinos, George P., Rehm, Heidi L., Relling, Mary V., Rennert, Gad, Rodriguez, Laura Lyman, Roden, Dan M., Shuldiner, Alan R., Sinha, Sukdeb, Tan, Patrick, Ulfendahl, Mats, Ward, Robyn, Williams, Marc S., Wong, John E. L., Green, Eric D., and Ginsburg, Geoffrey S.

Abstract

Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit from the sharing of approaches and lessons learned in other locales. The U.S. National Human Genome Research Institute and the National Academy of Medicine recently brought together 25 of these groups to compare projects, to examine the current state of implementation and desired near-term capabilities, and to identify opportunities for collaboration that promote the responsible practice of genomic medicine. Efforts to coalesce these groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in efforts to improve clinical care worldwide.

Published
2015

278. Tracking mesenchymal stromal cells using an ultra-bright TAT-functionalized plasmonic-active nanoplatform

Author

Yuan, Hsiangkuo, primary, Gomez, Jose A., additional, Chien, Jennifer S., additional, Zhang, Lunan, additional, Wilson, Christy M., additional, Li, Shuqin, additional, Fales, Andrew M., additional, Liu, Yang, additional, Grant, Gerald A., additional, Mirotsou, Maria, additional, Dzau, Victor J., additional, and Vo-Dinh, Tuan, additional

Published
2015
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284. Global implementation of genomic medicine: We are not alone

Author

Manolio, Teri A., primary, Abramowicz, Marc, additional, Al-Mulla, Fahd, additional, Anderson, Warwick, additional, Balling, Rudi, additional, Berger, Adam C., additional, Bleyl, Steven, additional, Chakravarti, Aravinda, additional, Chantratita, Wasun, additional, Chisholm, Rex L., additional, W. Dissanayake, Vajira H., additional, Dunn, Michael, additional, Dzau, Victor J., additional, Han, Bok-Ghee, additional, Hubbard, Tim, additional, Kolbe, Anne, additional, Korf, Bruce, additional, Kubo, Michiaki, additional, Lasko, Paul, additional, Leego, Erkki, additional, Mahasirimongkol, Surakameth, additional, Majumdar, Partha P., additional, Matthijs, Gert, additional, McLeod, Howard L., additional, Metspalu, Andres, additional, Meulien, Pierre, additional, Miyano, Satoru, additional, Naparstek, Yaakov, additional, O’Rourke, P. Pearl, additional, Patrinos, George P., additional, Rehm, Heidi L., additional, Relling, Mary V., additional, Rennert, Gad, additional, Rodriguez, Laura Lyman, additional, Roden, Dan M., additional, Shuldiner, Alan R., additional, Sinha, Sukdeb, additional, Tan, Patrick, additional, Ulfendahl, Mats, additional, Ward, Robyn, additional, Williams, Marc S., additional, L. Wong, John E., additional, Green, Eric D., additional, and Ginsburg, Geoffrey S., additional

Published
2015
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287. Salt Restriction Leads to Activation of Adult Renal Mesenchymal Stromal Cell–Like Cells via Prostaglandin E2 and E-Prostanoid Receptor 4

Author

Yang, Yanqiang, primary, Gomez, Jose A., additional, Herrera, Marcela, additional, Perez-Marco, Romelia, additional, Repenning, Peter, additional, Zhang, Zhiping, additional, Payne, Alan, additional, Pratt, Richard E., additional, Koller, Beverly, additional, Beierwaltes, William H., additional, Coffman, Thomas, additional, Mirotsou, Maria, additional, and Dzau, Victor J., additional

Published
2015
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289. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

Author

Gnecchi, Massimiliano, He, Huamei, Liang, Olin D, Melo, Luis G, Morello, Fulvio, Mu, Hui, Noiseux, Nicolas, Zhang, Lunan, Pratt, Richard E, Ingwall, Joanne S, and Dzau, Victor J

Abstract

Author(s): Massimiliano Gnecchi [1, 2]; Huamei He [2]; Olin D Liang [2]; Luis G Melo [1, 2, 3]; Fulvio Morello [1, 2]; Hui Mu [1, 2]; Nicolas Noiseux [2]; Lunan [...]

Published
2005
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290. SFRP2 Regulates Cardiomyogenic Differentiation by Inhibiting a Positive Transcriptional Autofeedback Loop of Wnt3a

Author

Deb, Arjun, Davis, Bryce H., Guo, Jian, Dzau, Victor J., Zhang, Zhiping, Mu, Hui, Huang, Jing, and Ni, Aiguo

Subjects
body regions, animal structures, embryonic structures
Abstract

Wnts comprise a family of 20 lipid-modified glycoproteins in mammals and play critical roles during embryological development and organogenesis of several organ systems, including the heart. They are required for mesoderm formation and have been implicated in promoting cardiomyogenic differentiation of mammalian embryonic stem cells, but the underlying mechanisms regulating Wnt signaling during cardiomyogenesis remain poorly understood. In this report, we show that in a pluripotent mouse embryonal carcinoma stem cell line, SFRP2 inhibits cardiomyogenic differentiation by regulating Wnt3a transcription. SFRP2 inhibited early stages of cardiomyogenesis, preventing mesoderm specification and maintaining the cells in the undifferentiated state. Using a gain- and loss-of-function approach, we demonstrate that although addition of recombinant SFRP2 decreased Wnt3a transcription and cardiomyogenic differentiation, silencing of Sfrp2 led to enhanced Wnt3a transcription, mesoderm formation, and increased cardiomyogenesis. We show that the inhibitory effects of SFRP2 on Wnt transcription are secondary to interruption of a positive feedback effect of Wnt3a on its own transcription. Wnt3a increased its own transcription via the canonical pathway and TCF4 family of transcription factors, and the inhibitory effects of SFRP2 on Wnt3a transcription were associated with disruption of downstream canonical Wnt signaling. The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a “checkpoint gene,” which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription.

Published
2008
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292. MicroRNA Induced Cardiac Reprogramming In Vivo

Author

Jayawardena, Tilanthi M., primary, Finch, Elizabeth A., additional, Zhang, Lunan, additional, Zhang, Hengtao, additional, Hodgkinson, Conrad P., additional, Pratt, Richard E., additional, Rosenberg, Paul B., additional, Mirotsou, Maria, additional, and Dzau, Victor J., additional

Published
2015
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