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Research findings, 'A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase,' are discussed in a new report. 'The flaviviral RNA-dependent RNA polymerase (RdRp) [...]

Investigators publish new data in the report 'microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti.' According to recent research from the United States, [...]

According to a study from Sao Paulo, Brazil, 'The interaction between dengue virus particles (DENV), sedimentation hemagglutinin particles (SHA), dengue virus envelope protein (Eprot), and solid surfaces was investigated by [...]

New research, 'Larvicidal potential of ethanolic extracts of dried fruits of three species of peppercorns against different instars of an indian strain of dengue fever mosquito, Aedes aegypti L. (Diptera: [...]

Fresh data on genetics and dengue fever are presented in the report 'Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3.' According to a study from [...]

'A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the [...]

Investigators publish new data in the report 'Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.' According to a study from Singapore, Singapore, 'We recently reported that (2R,3R,4R,5R)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is [...]

'The paper presents an innovative silicon nanowire (SiNW)-based sensor for highly sensitive and rapid detection of reverse-transcription-polymerase chain reaction (RT-PCR) product of Dengue serotype 2 (DEN-2). A specific peptide nucleic [...]

A new study, 'Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor,' is now available. According to a study from Oxford, the United Kingdom, 'The human [...]

Current study results from the report, 'Identification of a dengue virus-specific HLA-A*0201-restricted CD8+ T cell epitope,' have been published. According to recent research published in the Journal of Medical Virology, [...]

'Immatures of both Aedes aegypti and Aedes albopictus have been found in water-holding bromeliad axils in Brazil. Removal of these plants or their treatment with insecticides in public and private [...]

A new study, 'Comprehensive mapping of immunodominant and conserved serotype- and group-specific B-cell epitopes of nonstructural protein 1 from dengue virus type 1,' is now available. According to recent research [...]

'We present a stochastic dynamical model for the transmission of dengue that takes into account seasonal and spatial dynamics of the vector Aedes aegypti. It describes disease dynamics triggered by [...]

Fresh data on dengue fever are presented in the report 'Early diagnosis of dengue in travelers: comparison of a novel real-time RT-PCR, NS1 antigen detection and serology.' 'The increased traveling [...]

Investigators publish new data in the report 'Evolution, dispersal and replacement of American genotype dengue type 2 viruses in India (1956-2005): selection pressure and molecular clock analyses.' 'This study reports [...]

'Hemorrhagic syndrome is a hallmark of severe dengue diseases. We previously suggested a mechanism of molecular mimicry in which antibodies against dengue virus (DV) nonstructural protein 1 (NS1) cross-react with [...]

A report, 'Construction and characterization of a stable subgenomic replicon system of a Brazilian dengue virus type 3 strain (BR DEN3 290-02),' is newly published data in Journal of Virological [...]

'The envelope glycoprotein (E) of flavivirus is the major structural protein on the surface of the mature virions. The complexes of premembrane (prM) and E play important roles in virus [...]

A new study, 'Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis,' is now available. According to a study from Bangkok, Thailand, "Dengue virus capsid [...]

"The increased traveling to dengue endemic regions and the numerous epidemics have led to a rise in imported dengue. The laboratory diagnosis of acute dengue requires several types of tests [...]

According to a study from the United States, "Flavivirus assembles into an inert particle that requires proteolytic activation by furin to enable transmission to other hosts. We previously showed that [...]

"The aim of this work was to perform a systematic study of the effect of nonionic detergents on the activity of the dengue virus NS2B-NS3 protease. To ensure a high [...]

Research findings, 'Intersectoral coordination, community empowerment and dengue prevention: six years of controlled interventions in Playa Municipality, Havana, Cuba,' are discussed in a new report. "To document the process, outcome [...]

New investigation results, 'Recombinant nucleocapsid-like particles from dengue-2 virus induce protective CD4+ and CD8+ cells against viral encephalitis in mice,' are detailed in a study published in International Immunology. "Virus-like [...]

'Dengue is a major problem worldwide, and improving case management is a significant priority. In consultation with colleagues in Thailand changes ill management of hospitalized dengue cases were introduced in [...]

'The dengue virus has a single-stranded positive-sense RNA genome of similar to 10.700 nucleotides with a single open reading frame that encodes three structural (C, prM, and E) and seven [...]

'In 2007, physicians on Yap Island reported an outbreak of illness characterized by rash, conjunctivitis, and arthralgia. Although serum from some patients had IgM antibody against dengue virus, the illness [...]

'We presented our surveillance results on imported dengue cases in Taiwan during 2003-2007. A total of 542 imported dengue patients were identified,' scientists writing in the American Journal of Tropical [...]

'In the Caribbean, insecticide resistance is widely developed in Aedes aegypti and represents a serious obstacle for dengue vector control. The efficacy of pyrethroid and organophosphate Ultra-low volume space sprays [...]

According to a study from Singapore, Singapore, 'Recently, a dengue virus-induced apoptosis p53- and mitochondria-mediated were reported in human and animal cells. To understand further the underlying mechanisms, a p53-deficient [...]

According to a study from the United States, 'Dengue virus relies on a conformational change in its envelope protein, E, to fuse the viral lipid membrane with the endosomal membrane [...]

'Dengue virus (DENV) is a major cause of febrile illness and hemorrhagic fever in tropical and subtropical regions. Typically, patients presenting with acute dengue disease are viremic but may not [...]

'The full-length genomes of two DENV-1 viruses isolated during the 2005-2006 dengue incidents in Brunei were sequenced. Twenty five primer sets were designed to amplify contiguous overlapping fragments of approximately [...]

"Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka," [...]

Investigators publish new data in the report 'In-silico homology modeling of three isoforms of insect defensins from the dengue vector mosquito, Aedes aegypti (Linn., 1762).' 'Dengue is a serious public [...]

"Interferences between different antigens in the same vaccine formulation have been reported for some vaccines (e.g., polio vaccines, live attenuated dengue vaccine candidates). We examined interferences between the four serotypes [...]

Research findings, 'Mosquito-borne viruses in Europe,' are discussed in a new report. According to recent research from Brno, Czech Republic, 'The number of mosquito-borne viruses ('moboviruses') occurring in Europe since [...]

'Although serosurvey in human or animals is a useful and straightforward strategy routinely used for public health, it often faces different types of impediments: ethics, beliefs, limitation by animal owners, [...]

Researchers detail in 'Characterization of the interaction of domain III of the envelope protein of dengue virus with putative receptors from CHO cells,' new data in dengue fever. 'Domain III [...]

'In this report, the efficiency of Adultrap under field conditions is compared to a CDC backpack aspirator and to MosquiTRAP. An urban dengue-endemic area of Rio de Janeiro was selected [...]

"A deterministic model for the transmission dynamics of a strain of dengue disease, which allows transmission by exposed humans and mosquitoes, is developed and rigorously analysed. The model, consisting of [...]

'A method to map the specific site on dengue virus envelope protein (E) that interacts with cells and a neutralizing antibody is developed using serially truncated dengue virus type 2 [...]

According to a study from Taipei, Taiwan, "To investigate viral determinants and evolution linked to outbreak with increased severity, we examined dengue virus type 2 (DENV-2) sequences from plasma of [...]

Fresh data on dengue fever are presented in the report 'Emergence of an independent lineage of dengue virus type 1 (DENV-1) and its co-circulation with predominant DENV-3 during the 2006 [...]

Fresh data on dengue fever are presented in the report 'An alternative method for the synthesis of competitor RNA transcripts useful for specific detection and quantitation of dengue virus serotype [...]

'The Flavivirus NS5 protein possesses both (guanine-N7)-methyltransferase and nucleoside-2'-O methyltransferase activities required for sequential methylation of the cap structure present at the 5' end of the Flavivirus RNA genome. Seventeen [...]

'Aedes aegypti is the main vector of dengue viruses. The epidemiology of dengue fever remains poorly understood in Senegal,' investigators in Dakar, Senegal report (see also Dengue Fever). 'A sylvatic [...]

Investigators publish new data in the report 'Genetic analysis of Dengue 3 virus subtype III 5' and 3' non-coding regions.' 'The emergence of dengue hemorrhagic fever in Sri Lanka in [...]

Data detailed in 'Aedes aegypti, Aedes albopictus, and dengue in Argentina: current knowledge and future directions' have been presented. 'Since the reinfestation of South American countries by Ae. aegypti, dengue [...]

"Intracellular cleavage of immature flaviviruses is a critical step in assembly that generates the membrane fusion potential of the E glycoprotein. With cryo- electron microscopy we show that the immature [...]