Search

Your search keyword '"De Santis R"' showing total 926 results
Start Over Author "De Santis R"
926 results on '"De Santis R"'

251. Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches

Author

Ginevri, F, De Santis, R, Comoli, P, Pastorino, N, Rossi, C, Botti, G, Fontana, I, Nocera, Adriana, Cardillo, M, Ciardi, M R, Locatelli, Franco, Maccario, R, Perfumo, F, Azzi, A, Nocera, A, Locatelli, F (ORCID:0000-0002-7976-3654), Ginevri, F, De Santis, R, Comoli, P, Pastorino, N, Rossi, C, Botti, G, Fontana, I, Nocera, Adriana, Cardillo, M, Ciardi, M R, Locatelli, Franco, Maccario, R, Perfumo, F, Azzi, A, Nocera, A, and Locatelli, F (ORCID:0000-0002-7976-3654)

Abstract

Background. Although a growing body of literature regarding polyoma BK virus (BKV) infection and associated interstitial nephritis in kidney-allograft recipients is becoming available, the impact of BKV infection in the pediatric population has not been fully evaluated.Methods. In a retrospective analysis, we performed polymerase chain reaction (PCR) assays for BKV DNA in serum and urine samples from 100 pediatric kidney-allograft recipients referred to our institution in the last 5 years.Results. BKV viruria was observed in 26 of 100 patients, whereas BKV viremia was demonstrated in 5 patients. Serum creatinine was significantly higher in recipients with positive BK viremia compared with BKV DNA-negative patients (mean 2.66 vs. 1.14 mg/100 mL). Renal biopsy performed in 3 of 5 patients showed graft damage consistent with interstitial nephropathy. In the univariate analysis, negative antibody status of the recipient and the presence of mycophenolate mofetil in baseline immunosuppression were the two factors predictive of active BKV infection.Conclusions. Our study shows that BKV-associated nephropathy is a relevant complication in the pediatric kidney transplantation setting also. Identification of patients at risk of developing virus-associated nephropathy, through prospective quantification of viral load, could improve clinical outcome by allowing the use of timely preemptive therapy guided by BKV DNA levels.

Published
2003

253. Oxadivin reacts with tissues and efficiently uptakes biotinylated therapeutics

Author

De Santis, R., primary, Albertoni, C., additional, Rosi, A., additional, Leoni, B., additional, Verdoliva, A., additional, Bellofiore, P., additional, Rivieccio, V., additional, Petronzelli, F., additional, Anastasi, A.-M., additional, D’Alessio, V., additional, Nucera, E., additional, Chinol, M., additional, Paganelli, G., additional, Carminati, P., additional, and Nuzzolo, C.A., additional

Published
2009
Full Text
View/download PDF

265. Novel antitenascin antibody with increased tumour localisation for Pretargeted Antibody-Guided RadioImmunoTherapy (PAGRIT)

Author

De Santis, R, primary, Anastasi, A M, additional, D'Alessio, V, additional, Pelliccia, A, additional, Albertoni, C, additional, Rosi, A, additional, Leoni, B, additional, Lindstedt, R, additional, Petronzelli, F, additional, Dani, M, additional, Verdoliva, A, additional, Ippolito, A, additional, Campanile, N, additional, Manfredi, V, additional, Esposito, A, additional, Cassani, G, additional, Chinol, M, additional, Paganelli, G, additional, and Carminati, P, additional

Published
2003
Full Text
View/download PDF

266. Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches

Author

Ginevri, F., primary, de Santis, R., additional, Comoli, P., additional, Pastorino, N., additional, Rossi, C., additional, Botti, G., additional, Fontana, I., additional, Nocera, A., additional, Cardillo, M., additional, Ciardi, M. R., additional, Locatelli, F., additional, Maccario, R., additional, Perfumo, F., additional, and Azzi, A., additional

Published
2003
Full Text
View/download PDF

267. Mechanical Properties of Human Mineralized Connective Tissues.

Author

Bellomo, Nicola, Mollica, Francesco, Preziosi, Luigi, Rajagopal, K. R., De Santis, R., Ambrosio, L., Mollica, F., Netti, P., and Nicolais, L.

Abstract

Experimental work has to be tightly linked with modeling. In fact, successful modeling requires firstly comparison with experiments in order to verify its predictions or to set its range of validity. Secondly, experiments measuring the mechanical properties of tissues are needed as input to calibrate mechanical models of organs that can be used to run simulations in silico. In this chapter we wish to provide a comprehensive literature review covering the mechanical characterization of hard tissues, in particular compact bone, trabecular bone and dentine Elastic and strength properties of such tissues are carefully reviewed, together with fracture mechanics properties when available. Properties obtained from different measurement devices are gathered and compared with each other. The anisotropy and the inelasticity of the mechanical properties of hard tissues is particularly stressed [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

287. Study of the conformations of the molecules in amorphous polymers by computer simulation.

Author

Weiss, Armin, Fischer, E. W., Müller, F. Horst, Bonart, R., de Santis, R., and Zachmann, H. G.

Abstract

Copyright of Physik der Duroplaste und Anderer Polymerer is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1978
Full Text
View/download PDF

293. Fiber Post Adhesion to Resin Luting Cements in the Restoration of Endodontically-Treated Teeth.

Author

Prisco, D., de Santis, R., Mollica, F., Ambroso, L., Rengo, S., and Nicolais, L.

Subjects
ENDODONTICS, DENTAL fillings, TOOTH root diseases, DENTAL resins, DENTAL adhesives, FINITE element method, DENTAL pulp cavities, ROOT canal treatment, THERAPEUTICS
Abstract

Fiber posts are widely used in the restoration of endodontically treated teeth. Scientific evidence demonstrates that the mechanical performance of teeth restored with fiber posts in combination with resin luting cements is improved with respect to metallic post restorations. The post is cemented inside the root canal using low modulus elastic polymer resins. In this study, the mechanical resistance of four different post-cement systems was assessed by means of a micro-mechanical pull-out test assisted by a simulation using the finite element methodology. This is vitro test is specifically designed to accurately characterize the post-cement interface. The results show no significant difference among the adhesion properties of the various types of post-cement systems used. [ABSTRACT FROM AUTHOR]

Published
2003

294. A pulsational approach to the luminosity of horizontal branch stellar structures.

Author

de Santis, R. and Cassisi, S.

Subjects
*BOLOMETERS, *STELLAR luminosity function
Abstract

We discuss an alternative approach to constrain the absolute bolometric luminosity of zero-age horizontal branch (ZAHB) structures by using the observational pulsational properties of ab-type RR Lyrae stars, theoretical relations connecting these properties to the evolutionary ones, i.e. luminosity, mass and effective temperature, and also the location in the Hertzsprung–Russell diagram of the instability strip boundaries for fundamental pulsators. As the main goal of this work is to obtain an evaluation of the ZAHB bolometric luminosity as independent of stellar evolution theory as possible, we have minimized the use of evolutionary prescriptions, the only adopted evolutionary input being the allowed mass range for fundamental pulsators. Nevertheless, the effects on our final results related to these evolutionary prescriptions have been carefully checked. In order to test the accuracy of the current framework, we have carefully investigated the effective temperature scale provided by De Santis and adopted in the present work. It has been found that the pulsational colour–effective temperature scale fixed by this temperature scale and the relation between intrinsic (B-V)[sub 0] colour, blue amplitude and metallicity given by Caputo & De Santis appear fully consistent with both theoretical colour transformations, given by Castelli, Gratton & Kurucz and Buser & Kurucz, and a semi-empirical one, provided by Green. In contrast, there is a large discrepancy between this pulsational colour–temperature scale and the one based on the Kurucz model atmospheres. The effects of adopting the temperature scale of Catelan, Sweigart & Borissova have been investigated. The reliability of the method is shown by applying it to a selected sample of globular clusters (GCs), the heavy element abundances of which cover almost all the complete GC metallicity range. In order to verify the accuracy of the results obtained by using ab-type RR Lyrae stars, a similar analysis has also been performed by using both observational and theoretical evidence for first-overtone variables. The results obtained for the ZAHB bolometric luminosities have been critically analysed and a comparison with recent evolutionary prescriptions has also been performed. The existence of evident mismatches between current results and some evolutionary models has been verified and discussed. Finally, our investigation has been extended to field variables to check for a luminosity difference between cluster RR Lyrae stars and field ones as suggested by Gratton. The comparison between the pulsational properties of field and cluster variables does not show the existence of any significant difference in their intrinsic luminosity, thus providing further support to the results obtained by Catelan. [ABSTRACT FROM AUTHOR]

Published
1999
Full Text
View/download PDF

298. Dynamic mechanical behavior of PMMA based bone cements in wet environment

Author

De Santis, R., Mollica, F., Ambrosio, L., Nicolais, L., and Ronca, D.

Abstract

The mechanical properties of three wet commercial bone cements, namely Braxel (from Bioland®), Simplex-P (from Howmedica®) and CMW1-G (from DePuy®) are investigated by means of stress relaxation and dynamic mechanical analysis (DMA). The geometry of loading that was used is the three point bending method (ASTM D790); all the tests were performed in a water chamber by means of temperature sweeps between 17 and 57 °C and spanning four frequency decades. The results show that viscoelastic properties are strongly dependent on specimen conditioning (i.e. water uptake and heat treatment). The results also show that all the cements that were analyzed show mechanical properties which are intermediate between the ones of the cancellous bone and of the metals of which prostheses are normally made. As a consequence, the cement is able to reduce the stress concentrations due to the interfacing of materials which have very different stiffnesses. Moreover, the results of the DMA, particularly the ones concerning the damping factor (tan δ), indicate that at body temperature the bone cements tested show an increased capacity of dissipation, the higher is the loading frequency, thus displaying shock absorbing properties.

Published
2003
Full Text
View/download PDF

299. Spatial and structural dependence of mechanical properties of porcine intervertebral disc

Author

Causa, F., Manto, L., Borzacchiello, A., De Santis, R., Netti, P., Ambrosio, L., and Nicolais, L.

Abstract

Structure–function relationship of natural tissues is crucial to design a device mimicking the structures present in human body. For this purpose, to provide guidelines to design an intervertebral disc (IVD) substitute, in this study the influence of the spatial location and structural components on the mechanical properties of porcine IVD was investigated. Local compressive stiffness (LCS) was measured on the overall disc, also constrained between the two adjacent vertebrae: the dependence on the lumbar position was evaluated. The compliance values in the anterior position (A) were higher than both in the central posterior (CP) and in the lateral-posterior (RP, LP) locations. The values of Young's Modulus (74.67±6.03 MPa) and compression break load (1.36×104±0.09×104N) of the disc were also evaluated by distributed compression test. The NP rheological behavior was typical of weak-gels, with elastic modulus G′ always higher than viscous modulus G″ all over the frequency range investigated (G′ and G″ respectively equal to 320 and 85 Pa at 1 Hz) and with the moduli trends were almost parallel to each other.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results