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255. Manifestaciones atípicas de la infección por parvovirus B19

Author

Morales Betancourt, P. C., Pérez Crespo, R., Avilla Hernández, J. M., and Cervera Bravo, A.

Subjects
Pulmonary edema, Trombopenia, Edema pulmonar, Parvovirus B19, Thrombocytopenia
Abstract

La principal manifestación de la primoinfección por parvovirus B19 suele ser el eritema infeccioso. La mayoría de las infecciones ocurren durante la infancia y la adolescencia, con una seroprevalencia cercana al 50% a los 20 años de edad. Aunque la infección primaria suele ser leve y de resolución espontánea, en ocasiones puede presentarse de forma atípica, en forma de artropatía, citopenias o distrés respiratorio. The most common clinical feature of parvovirus B19 primary infection is the erythema infectiosum. Most of the infections occur during childhood and adolescence, the seroprevalence is approximately 50% at 20 years of age. Although the primary infection is mild and self-limited, there are unusual presentations, such as arthropathy, cytopenias or acute lung injury.

Published
2015

256. A Simple and Reliable Synthesis of Superparamagnetic Magnetite Nanoparticles by Thermal Decomposition of Fe(acac)3.

Author

Toyos-Rodríguez, C., Calleja-García, J., Torres-Sánchez, L., López, A., Abu-Dief, Ahmed M., Costa, A., Elbaile, L., Crespo, R. D., Garitaonandia, J. S., Lastra, E., García, J. A., and García-Alonso, F. J.

Subjects
SUPERPARAMAGNETIC materials, MAGNETITE, MAGNETIC nanoparticles, NANOPARTICLES, MAGNETIZATION
Abstract

Magnetic nanoparticles have been largely proposed as means of technological tools due to its value in different fields, especially in biomedicine. Herein, we present a robust, highly reproducible and low-cost method to obtain superparamagnetic magnetite nanoparticles (MNP-II) of about 15±5 nm diameter by thermal decomposition of [Fe(acac)3] in a one-pot, two-step method. In the first step, magnetite nanoparticles (MNP-I) of lower size, 9±4 nm, with a saturation magnetization (MS) of 65 emu/g and a coercive field (Hc) of 1 Oe are obtained. In the second step, those particles MNP-I act as seeds for the final MNP-II which present a saturation magnetization of 70 emu/g and a coercive field of 12 Oe. [ABSTRACT FROM AUTHOR]

Published
2019
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257. Applied Research Note: Comparison of Bone Quality in Table Egg Layers by Quantitative Ultrasound, 3-Point-Bending Test, and Ash Content

Author

Crespo, R., Poudel, I., Malheiros, D.M., Anderson, K.E., and Malheiros, R.D.

Abstract

This study aimed to compare the performance of two quantitative ultrasound (QUS) devices and to investigate the possible relationship between bone density, measured by speed of sound (SOS), and the biomechanical properties of bone. The bone density of humerus and tarsometatarsus of 46 29-week-old laying hens housed in conventional cages were measured with two QUS devices. After testing, the birds were humanely euthanized and their left tibiotarsus and tarsometatarsus were collected. The diameter of these bones was measured at mid-shaft. Bending moment and peak force were evaluated using a TA-HD Plus instrument. Statistical analysis was performed in JMP Pro 16. For all the analyses, significance was set at P< 0.05. There was poor agreement in the SOS results between both devices. There was a moderate positive linear correlation (r2> 0.6) between bending moment and peak force. No significant linear correlation was observed between the bone diameter and the bending moment or the peak force, or between SOS or bone ash content and any of the mechanical properties measured. A nominal logistic fit model was used to compare low vs normal bone density to the biomechanical properties. A bone was defined to have low density if its SOS was below one standard deviation from the mean. A model that linked all 3 biomechanical properties (P=0.0173) was significantly correlated with the density (low vs normal) of tibiotarsi. Furthermore, the hen's tarsometatarsus with a higher bending moment and lower peak force had an increased odds ratio of low density tibiotarsi (P=0.0293). This study failed to demonstrate a relation between the SOS and biomechanical properties of bone. While QUS was non-invasive assessment, the devices provided minimal or no association with the mechanical or ash content of the bones. Testing and validation of non-invasive tools are needed to expand our understanding of bone health and offer early detection of bone loss mass in layer flocks in longitudinal studies to develop effective management and intervention strategies.

Published
2024
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258. Nuclear astrophysics with radioactive ions at FAIR

Author

Reifarth, R., Altstadt, S., Göbel, K., Heftrich, T., Heil, M., Koloczek, A., Langer, C., Plag, R., Pohl, M., Sonnabend, K., Weigand, M., Adachi, T., Aksouh, F., Al-Khalili, J., Algarawi, M., Alghamdi, S., Alkhazov, G., Alkhomashi, N., Alvarez-Pol, H., Alvarez-Rodriguez, R., Andreev, V., Andrei, B., Atar, L., Aumann, T., Avdeichikov, V., Bacri, C., Bagchi, S., Barbieri, C., Beceiro, S., Beck, C., Beinrucker, C., Belier, G., Bemmerer, D., Bendel, M., Benlliure, J., Benzoni, G., Berjillos, R., Bertini, D., Bertulani, C., Bishop, S., Blasi, N., Bloch, T., Blumenfeld, Y., Bonaccorso, A., Boretzky, K., Botvina, A., Boudard, A., Boutachkov, P., Boztosun, I., Bracco, A., Brambilla, S., Monago, J. B., Caamano, M., Caesar, C., Camera, F., Casarejos, E., Catford, W., Cederkall, J., Cederwall, B., Chartier, M., Chatillon, A., Cherciu, M., Chulkov, L., Coleman-Smith, P., Cortina-Gil, D., Crespi, F., Crespo, R., Cresswell, J., Csatlós, M., Déchery, F., Davids, B., Davinson, T., Derya, V., Detistov, P., Fernandez, P. D., Dijulio, D., Dmitry, S., Doré, D., Dueñas, J., Dupont, E., Egelhof, P., Egorova, I., Elekes, Z., Enders, J., Endres, J., Ershov, S., Ershova, O., Fernandez-Dominguez, B., Fetisov, A., Fiori, E., Fomichev, A., Fonseca, M., Fraile, L., Freer, M., Friese, J., Borge, M. G., Redondo, D. G., Gannon, S., Garg, U., Gasparic, I., Gasques, L., Gastineau, B., Geissel, H., Gernhäuser, R., Ghosh, T., Gilbert, M., Glorius, J., Golubev, P., Gorshkov, A., Gourishetty, A., Grigorenko, L., Gulyas, J., Haiduc, M., Hammache, F., Harakeh, M., Hass, M., Heine, M., Hennig, A., Henriques, A., Herzberg, R., Holl, M., Ignatov, A., Ignatyuk, A., Ilieva, S., Ivanov, M., Iwasa, N., Jakobsson, B., Johansson, H., Jonson, B., Joshi, P., Junghans, A., Jurado, B., Körner, G., Kalantar, N., Kanungo, R., Kelic-Heil, A., Kezzar, K., Khan, E., Khanzadeev, A., Kiselev, O., Kogimtzis, M., Körper, D., Kräckmann, S., Kröll, T., Krücken, R., Krasznahorkay, A., Kratz, J., Kresan, D., Krings, T., Krumbholz, A., Krupko, S., Kulessa, R., Kumar, S., Kurz, N., Kuzmin, E., Labiche, M., Langanke, K., Lazarus, I., Le Bleis, T., Lederer, C., Lemasson, A., Lemmon, R., Liberati, V., Litvinov, Y., Löher, B., Herraiz, J. L., Münzenberg, G., Machado, J., Maev, E., Mahata, K., Mancusi, D., Marganiec, J., Perez, M. M., Marusov, V., Mengoni, D., Million, B., Morcelle, V., Moreno, O., Movsesyan, A., Nacher, E., Najafi, M., Nakamura, T., Naqvi, F., Nikolski, E., Nilsson, T., Nociforo, C., Nolan, P., Novatsky, B., Nyman, G., Ornelas, A., Palit, R., Pandit, S., Panin, V., Paradela, C., Parkar, V., Paschalis, S., Pawłowski, P., Perea, A., Pereira, J., Petrache, C., Petri, M., Pickstone, S., Pietralla, N., Pietri, S., Pivovarov, Y., Potlog, P., Prokofiev, A., Rastrepina, G., Rauscher, T., Ribeiro, G., Ricciardi, M., Richter, A., Rigollet, C., Riisager, K., Rios, A., Ritter, C., Frutos, T. R., Vignote, J. R., Röder, M., Romig, C., Rossi, D., Roussel-Chomaz, P., Rout, P., Roy, S., Söderström, P., Sarkar, M. S., Sakuta, S., Salsac, M., Sampson, J., Del Rio Saez, J. S., Rosado, J. S., Sanjari, S., Sarriguren, P., Sauerwein, A., Savran, D., Scheidenberger, C., Scheit, H., Schmidt, S., Schmitt, C., Schnorrenberger, L., Schrock, P., Schwengner, R., Seddon, D., Sherrill, B., Shrivastava, A., Sidorchuk, S., Silva, J., Simon, H., Simpson, E., Singh, P., Slobodan, D., Sohler, D., Spieker, M., Stach, D., Stan, E., Stanoiu, M., Stepantsov, S., Stevenson, P., Strieder, F., Stuhl, L., Suda, T., Sümmerer, K., Streicher, B., Taieb, J., Takechi, M., Tanihata, I., Taylor, J., Tengblad, O., Ter-Akopian, G., Terashima, S., Teubig, P., Thies, R., Thoennessen, M., Thomas, T., Thornhill, J., Thungström, Göran, Timar, J., Togano, Y., Tomohiro, U., Tornyi, T., Tostevin, J., Townsley, C., Trautmann, W., Trivedi, T., Typel, S., Uberseder, E., Udias, J., Uesaka, T., Uvarov, L., Vajta, Z., Velho, P., Vikhrov, V., Volknandt, M., Volkov, V., Von Neumann-Cosel, P., Von Schmid, M., Wagner, A., Wamers, F., Weick, H., Wells, D., Westerberg, L., Wieland, O., Wiescher, M., Wimmer, C., Wimmer, K., Winfield, J. S., Winkel, M., Woods, P., Wyss, R., Yakorev, D., Yavor, M., Cardona, J. Z., Zartova, I., Zerguerras, T., Zgura, M., Zhdanov, A., Zhukov, M., Zieblinski, M., Zilges, A., Zuber, K., Reifarth, R., Altstadt, S., Göbel, K., Heftrich, T., Heil, M., Koloczek, A., Langer, C., Plag, R., Pohl, M., Sonnabend, K., Weigand, M., Adachi, T., Aksouh, F., Al-Khalili, J., Algarawi, M., Alghamdi, S., Alkhazov, G., Alkhomashi, N., Alvarez-Pol, H., Alvarez-Rodriguez, R., Andreev, V., Andrei, B., Atar, L., Aumann, T., Avdeichikov, V., Bacri, C., Bagchi, S., Barbieri, C., Beceiro, S., Beck, C., Beinrucker, C., Belier, G., Bemmerer, D., Bendel, M., Benlliure, J., Benzoni, G., Berjillos, R., Bertini, D., Bertulani, C., Bishop, S., Blasi, N., Bloch, T., Blumenfeld, Y., Bonaccorso, A., Boretzky, K., Botvina, A., Boudard, A., Boutachkov, P., Boztosun, I., Bracco, A., Brambilla, S., Monago, J. B., Caamano, M., Caesar, C., Camera, F., Casarejos, E., Catford, W., Cederkall, J., Cederwall, B., Chartier, M., Chatillon, A., Cherciu, M., Chulkov, L., Coleman-Smith, P., Cortina-Gil, D., Crespi, F., Crespo, R., Cresswell, J., Csatlós, M., Déchery, F., Davids, B., Davinson, T., Derya, V., Detistov, P., Fernandez, P. D., Dijulio, D., Dmitry, S., Doré, D., Dueñas, J., Dupont, E., Egelhof, P., Egorova, I., Elekes, Z., Enders, J., Endres, J., Ershov, S., Ershova, O., Fernandez-Dominguez, B., Fetisov, A., Fiori, E., Fomichev, A., Fonseca, M., Fraile, L., Freer, M., Friese, J., Borge, M. G., Redondo, D. G., Gannon, S., Garg, U., Gasparic, I., Gasques, L., Gastineau, B., Geissel, H., Gernhäuser, R., Ghosh, T., Gilbert, M., Glorius, J., Golubev, P., Gorshkov, A., Gourishetty, A., Grigorenko, L., Gulyas, J., Haiduc, M., Hammache, F., Harakeh, M., Hass, M., Heine, M., Hennig, A., Henriques, A., Herzberg, R., Holl, M., Ignatov, A., Ignatyuk, A., Ilieva, S., Ivanov, M., Iwasa, N., Jakobsson, B., Johansson, H., Jonson, B., Joshi, P., Junghans, A., Jurado, B., Körner, G., Kalantar, N., Kanungo, R., Kelic-Heil, A., Kezzar, K., Khan, E., Khanzadeev, A., Kiselev, O., Kogimtzis, M., Körper, D., Kräckmann, S., Kröll, T., Krücken, R., Krasznahorkay, A., Kratz, J., Kresan, D., Krings, T., Krumbholz, A., Krupko, S., Kulessa, R., Kumar, S., Kurz, N., Kuzmin, E., Labiche, M., Langanke, K., Lazarus, I., Le Bleis, T., Lederer, C., Lemasson, A., Lemmon, R., Liberati, V., Litvinov, Y., Löher, B., Herraiz, J. L., Münzenberg, G., Machado, J., Maev, E., Mahata, K., Mancusi, D., Marganiec, J., Perez, M. M., Marusov, V., Mengoni, D., Million, B., Morcelle, V., Moreno, O., Movsesyan, A., Nacher, E., Najafi, M., Nakamura, T., Naqvi, F., Nikolski, E., Nilsson, T., Nociforo, C., Nolan, P., Novatsky, B., Nyman, G., Ornelas, A., Palit, R., Pandit, S., Panin, V., Paradela, C., Parkar, V., Paschalis, S., Pawłowski, P., Perea, A., Pereira, J., Petrache, C., Petri, M., Pickstone, S., Pietralla, N., Pietri, S., Pivovarov, Y., Potlog, P., Prokofiev, A., Rastrepina, G., Rauscher, T., Ribeiro, G., Ricciardi, M., Richter, A., Rigollet, C., Riisager, K., Rios, A., Ritter, C., Frutos, T. R., Vignote, J. R., Röder, M., Romig, C., Rossi, D., Roussel-Chomaz, P., Rout, P., Roy, S., Söderström, P., Sarkar, M. S., Sakuta, S., Salsac, M., Sampson, J., Del Rio Saez, J. S., Rosado, J. S., Sanjari, S., Sarriguren, P., Sauerwein, A., Savran, D., Scheidenberger, C., Scheit, H., Schmidt, S., Schmitt, C., Schnorrenberger, L., Schrock, P., Schwengner, R., Seddon, D., Sherrill, B., Shrivastava, A., Sidorchuk, S., Silva, J., Simon, H., Simpson, E., Singh, P., Slobodan, D., Sohler, D., Spieker, M., Stach, D., Stan, E., Stanoiu, M., Stepantsov, S., Stevenson, P., Strieder, F., Stuhl, L., Suda, T., Sümmerer, K., Streicher, B., Taieb, J., Takechi, M., Tanihata, I., Taylor, J., Tengblad, O., Ter-Akopian, G., Terashima, S., Teubig, P., Thies, R., Thoennessen, M., Thomas, T., Thornhill, J., Thungström, Göran, Timar, J., Togano, Y., Tomohiro, U., Tornyi, T., Tostevin, J., Townsley, C., Trautmann, W., Trivedi, T., Typel, S., Uberseder, E., Udias, J., Uesaka, T., Uvarov, L., Vajta, Z., Velho, P., Vikhrov, V., Volknandt, M., Volkov, V., Von Neumann-Cosel, P., Von Schmid, M., Wagner, A., Wamers, F., Weick, H., Wells, D., Westerberg, L., Wieland, O., Wiescher, M., Wimmer, C., Wimmer, K., Winfield, J. S., Winkel, M., Woods, P., Wyss, R., Yakorev, D., Yavor, M., Cardona, J. Z., Zartova, I., Zerguerras, T., Zgura, M., Zhdanov, A., Zhukov, M., Zieblinski, M., Zilges, A., and Zuber, K.

Abstract

The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process, β-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes., Conference Paper

Published
2016
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259. Nuclear astrophysics with radioactive ions at FAIR

Author

Reifarthl, R., Altstadt, S., Goebell, K., Heftrich, T., Heil, M., Koloczek, A., Langer, C., Plag, R., Pohl, M., Sonnabend, K., Weigand, M., Adachi, T., Aksouh, F., Al-Khalili, J., AlGarawi, M., AlGhamdi, S., Alkhazov, G., Alkhomashi, N., Alvarez-Pol, H., Alvarez-Rodriguez, R., Andreev, V., Andrei, B., Atar, L., Aumann, T., Adeichikov, V., Bacri, C., Bagchi, S., Barbieri, C., Beceiro, S., Beck, C., Beinrucker, C., Belier, G., Bemmerer, D., Bendel, M., Benlliure, J., Benzoni, G., Berjillos, R., Bertini, D., Bertulani, C., Bishop, S., Blasi, N., Bloch, T., Blumenfeld, Y., Bonaccorso, A., Boretzky, K., Botvina, A., Boudard, A., Boutachkov, P., Boztosun, I., Bracco, A., Brambilla, S., Briz Monago, J., Caamano, M., Caesar, C., Camera, F., Casarejos, E., Catford, W., Cederkall, J., Cederwall, Bo, Chartier, M., Chatillon, A., Cherciu, M., Chulkov, L., Coleman-Smith, P., Cortina-Gil, D., Crespi, F., Crespo, R., Cresswell, J., Csatlos, M., Dechery, F., Davids, B., Davinson, T., Derya, V., Detistov, P., Diaz Fernandez, P., DiJuliot, D., Dmitry, S., Dore, D., Duenas, J., Dupont, E., Egelhof, P., Egorova, I., Elekes, Z., Enders, J., Endres, J., Ershov, S., Ershova, O., Fernandez-Dominguez, B., Fetisov, A., Fiori, E., Fomichev, A., Fonseca, M., Fraile, L., Freer, M., Friese, J., Borge, M. G., Galaviz Redondo, D., Gannon, S., Garg, U., Gasparic, I., Gasques, L., Gastineau, B., Geissel, H., Gernhaeuser, R., Ghosh, T., Gilbert, M., Glorius, J., Golubev, P., Gorshkov, A., Gourishett, A., Grigorenko, L., Gulyas, J., Haiduc, M., Hammache, F., Harakeh, M., Hass, M., Heine, M., Hennig, A., Henriques, A., Herzberg, R., Holl, M., Ignatov, A., Ignatyuk, A., Ilieva, S., Ivanov, M., Iwasa, N., Jakobsson, B., Johansson, H., Jonson, B., Joshi, P., Junghans, A., Jurado, B., Koerner, G., Kalantar, N., Kanungo, R., Kelic-Heil, A., Kezzar, K., Khan, E., Khanzadeev, A., Kiselev, O., Kogimtzis, M., Koerper, D., Kraeckmann, S., Kroell, T., Kruecken, R., Krasznahorkay, A., Kratz, J., Kresan, D., Krings, T., Krumbholz, A., Krupko, S., Kulessa, R., Kumar, S., Kurz, N., Kuzmin, E., Labiche, M., Langanke, K., Lazarus, I., Le Bleis, T., Lederer, C., Lemasson, A., Lemmon, R., Liberati, V., Litvinov, Y., Loeher, B., Lopez Herraiz, J., Muenzenberg, G., Machado, J., Maev, E., Mahata, K., Mancusi, D., Marganiec, J., Martinez Perez, M., Marusov, V., Mengoni, D., Million, B., Morcelle, V., Moreno, O., Movsesyan, A., Nacher, E., Najafi, M., Nakamura, T., Naqvi, F., Nikolski, E., Nilsson, T., Nociforo, C., Nolan, P., Novatsky, B., Nyman, G., Ornelas, A., Palit, R., Pandit, S., Panin, V., Paradela, C., Parkar, V., Paschalis, S., Pawlowski, P., Perea, A., Pereira, J., Petrache, C., Petri, M., Pickstone, S., Pietralla, N., Pietri, S., Pivovarov, Y., Potlog, P., Prokofiev, A., Rastrepina, G., Rauscher, T., Ribeiro, G., Ricciardi, M., Richter, A., Rigollet, C., Riisager, K., Rios, A., Ritter, C., Frutos, T. Rodriguez, Rodriguez Vignote, J., Roeder, M., Romig, C., Rossi, D., Roussel-Chomaz, P., Rout, P., Roy, S., Soederstroem, P., Sarkar, M. Saha, Sakuta, S., Salsac, M., Sampson, J., del Rio Saez, J. Sanchez, Sanchez Rosado, J., Sanjari, S., Sarriguren, P., Sauerwein, A., Savran, D., Scheidenberger, C., Scheit, H., Schmidt, S., Schmitt, C., Schnorrenberger, L., Schrock, P., Schwengner, R., Seddon, D., Sherrill, B., Shrivastava, A., Sidorchuk, S., Silva, J., Simon, H., Simpson, E., Singh, P., Slobodan, D., Sohler, D., Spieker, M., Stach, D., Stan, E., Stanoiu, M., Stepantsov, S., Stevenson, P., Strieder, F., Stuhl, L., Suda, T., Suemmerer, K., Streicher, B., Taieb, J., Takechi, M., Tanihata, I., Taylor, J., Tengblad, O., Ter-Akopian, G., Terashima, S., Teubig, P., Thies, R., Thoennessen, M., Thomas, T., Thornhill, J., Thungstrom, G., Timar, J., Togano, Y., Tomohiro, U., Tornyi, T., Tostevin, J., Townsley, C., Trautmann, W., Trivedi, T., Typel, S., Uberseder, E., Udias, J., Uesaka, T., Uvarov, L., Vajta, Z., Velho, P., Vikhrov, V., Volknandt, M., Volkov, V., von Neumann-Cose, P., von Schmid, M., Wagner, A., Wamers, F., Weick, H., Wells, D., Westerberg, L., Wieland, O., Wiescher, M., Wimmer, C., Wimmer, K., Winfield, J. S., Winkel, M., Woods, P., Wyss, Ramon, Yakorev, D., Yavor, M., Cardona, J. Zamora, Zartova, I., Zerguerras, T., Zgura, I., Zhdanov, A., Zhukov, M., Zieblinski, M., Zilges, A., Zuber, K., Reifarthl, R., Altstadt, S., Goebell, K., Heftrich, T., Heil, M., Koloczek, A., Langer, C., Plag, R., Pohl, M., Sonnabend, K., Weigand, M., Adachi, T., Aksouh, F., Al-Khalili, J., AlGarawi, M., AlGhamdi, S., Alkhazov, G., Alkhomashi, N., Alvarez-Pol, H., Alvarez-Rodriguez, R., Andreev, V., Andrei, B., Atar, L., Aumann, T., Adeichikov, V., Bacri, C., Bagchi, S., Barbieri, C., Beceiro, S., Beck, C., Beinrucker, C., Belier, G., Bemmerer, D., Bendel, M., Benlliure, J., Benzoni, G., Berjillos, R., Bertini, D., Bertulani, C., Bishop, S., Blasi, N., Bloch, T., Blumenfeld, Y., Bonaccorso, A., Boretzky, K., Botvina, A., Boudard, A., Boutachkov, P., Boztosun, I., Bracco, A., Brambilla, S., Briz Monago, J., Caamano, M., Caesar, C., Camera, F., Casarejos, E., Catford, W., Cederkall, J., Cederwall, Bo, Chartier, M., Chatillon, A., Cherciu, M., Chulkov, L., Coleman-Smith, P., Cortina-Gil, D., Crespi, F., Crespo, R., Cresswell, J., Csatlos, M., Dechery, F., Davids, B., Davinson, T., Derya, V., Detistov, P., Diaz Fernandez, P., DiJuliot, D., Dmitry, S., Dore, D., Duenas, J., Dupont, E., Egelhof, P., Egorova, I., Elekes, Z., Enders, J., Endres, J., Ershov, S., Ershova, O., Fernandez-Dominguez, B., Fetisov, A., Fiori, E., Fomichev, A., Fonseca, M., Fraile, L., Freer, M., Friese, J., Borge, M. G., Galaviz Redondo, D., Gannon, S., Garg, U., Gasparic, I., Gasques, L., Gastineau, B., Geissel, H., Gernhaeuser, R., Ghosh, T., Gilbert, M., Glorius, J., Golubev, P., Gorshkov, A., Gourishett, A., Grigorenko, L., Gulyas, J., Haiduc, M., Hammache, F., Harakeh, M., Hass, M., Heine, M., Hennig, A., Henriques, A., Herzberg, R., Holl, M., Ignatov, A., Ignatyuk, A., Ilieva, S., Ivanov, M., Iwasa, N., Jakobsson, B., Johansson, H., Jonson, B., Joshi, P., Junghans, A., Jurado, B., Koerner, G., Kalantar, N., Kanungo, R., Kelic-Heil, A., Kezzar, K., Khan, E., Khanzadeev, A., Kiselev, O., Kogimtzis, M., Koerper, D., Kraeckmann, S., Kroell, T., Kruecken, R., Krasznahorkay, A., Kratz, J., Kresan, D., Krings, T., Krumbholz, A., Krupko, S., Kulessa, R., Kumar, S., Kurz, N., Kuzmin, E., Labiche, M., Langanke, K., Lazarus, I., Le Bleis, T., Lederer, C., Lemasson, A., Lemmon, R., Liberati, V., Litvinov, Y., Loeher, B., Lopez Herraiz, J., Muenzenberg, G., Machado, J., Maev, E., Mahata, K., Mancusi, D., Marganiec, J., Martinez Perez, M., Marusov, V., Mengoni, D., Million, B., Morcelle, V., Moreno, O., Movsesyan, A., Nacher, E., Najafi, M., Nakamura, T., Naqvi, F., Nikolski, E., Nilsson, T., Nociforo, C., Nolan, P., Novatsky, B., Nyman, G., Ornelas, A., Palit, R., Pandit, S., Panin, V., Paradela, C., Parkar, V., Paschalis, S., Pawlowski, P., Perea, A., Pereira, J., Petrache, C., Petri, M., Pickstone, S., Pietralla, N., Pietri, S., Pivovarov, Y., Potlog, P., Prokofiev, A., Rastrepina, G., Rauscher, T., Ribeiro, G., Ricciardi, M., Richter, A., Rigollet, C., Riisager, K., Rios, A., Ritter, C., Frutos, T. Rodriguez, Rodriguez Vignote, J., Roeder, M., Romig, C., Rossi, D., Roussel-Chomaz, P., Rout, P., Roy, S., Soederstroem, P., Sarkar, M. Saha, Sakuta, S., Salsac, M., Sampson, J., del Rio Saez, J. Sanchez, Sanchez Rosado, J., Sanjari, S., Sarriguren, P., Sauerwein, A., Savran, D., Scheidenberger, C., Scheit, H., Schmidt, S., Schmitt, C., Schnorrenberger, L., Schrock, P., Schwengner, R., Seddon, D., Sherrill, B., Shrivastava, A., Sidorchuk, S., Silva, J., Simon, H., Simpson, E., Singh, P., Slobodan, D., Sohler, D., Spieker, M., Stach, D., Stan, E., Stanoiu, M., Stepantsov, S., Stevenson, P., Strieder, F., Stuhl, L., Suda, T., Suemmerer, K., Streicher, B., Taieb, J., Takechi, M., Tanihata, I., Taylor, J., Tengblad, O., Ter-Akopian, G., Terashima, S., Teubig, P., Thies, R., Thoennessen, M., Thomas, T., Thornhill, J., Thungstrom, G., Timar, J., Togano, Y., Tomohiro, U., Tornyi, T., Tostevin, J., Townsley, C., Trautmann, W., Trivedi, T., Typel, S., Uberseder, E., Udias, J., Uesaka, T., Uvarov, L., Vajta, Z., Velho, P., Vikhrov, V., Volknandt, M., Volkov, V., von Neumann-Cose, P., von Schmid, M., Wagner, A., Wamers, F., Weick, H., Wells, D., Westerberg, L., Wieland, O., Wiescher, M., Wimmer, C., Wimmer, K., Winfield, J. S., Winkel, M., Woods, P., Wyss, Ramon, Yakorev, D., Yavor, M., Cardona, J. Zamora, Zartova, I., Zerguerras, T., Zgura, I., Zhdanov, A., Zhukov, M., Zieblinski, M., Zilges, A., and Zuber, K.

Abstract

The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process beta-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes., QC 20160224

Published
2016
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260. Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae.

Author

Bossé, JT, Chaudhuri, RR, Li, Y, Leanse, LG, Fernandez Crespo, R, Coupland, P, Holden, MTG, Bazzolli, DM, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR, Bossé, JT, Chaudhuri, RR, Li, Y, Leanse, LG, Fernandez Crespo, R, Coupland, P, Holden, MTG, Bazzolli, DM, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, and Langford, PR

Abstract

We report here the complete annotated genome sequence of a clinical serovar 8 isolate Actinobacillus pleuropneumoniae MIDG2331. Unlike the serovar 8 reference strain 405, MIDG2331 is amenable to genetic manipulation via natural transformation as well as conjugation, making it ideal for studies of gene function.

Published
2016

262. [Untitled]

Author

Bremmer Jr., R.H., Porck, M.H., Crespo, R., Jacobs, J.G.A.M., Onderdelinden, S., Smith, P.J., Ruiter, F., Walthaus, R., and Wilbers, U.

Published
2014

264. Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study

Author

Roberts, J. A., Stove, V., De Waele, J. J., Sipinkoski, B., McWhinney, B., Ungerer, J. P. J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, K. -M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Starr, T., Wallis, S. C., Lipman, J., Paul, S., Ribas, A. M., DeCrop, L., Spapen, H., Wauters, J., Dugernier, T., Jorens, P., Dapper, I., De Backer, D., Taccone, F. S., Ruano, L., Afonso, E., Alvarez-Lerma, F., Gracia-Arnillas, M. P., Fernández, F., Feijoo, N., Bardolet, N., Rovira, A., Garro, P., Colon, D., Castillo, C., Fernado, J., Lopez, M. J., Fernandez, J. L., Arribas, A. M., Teja, J. L., Ots, E., Montejo, J. C., Catalan, M., Prieto, I., Gonzalo, G., Galvan, B., Blasco, M. A., Meyer, E., Nogal, F. D., Vidaur, L., Sebastian, R., Garde, P. M., Velasco Mdel, M., Crespo, R. Z., Esperatti, M., Torres, A., Baldesi, O., Dupont, H., Mahjoub, Y., Lasocki, S., Constantin, J. M., Payen, J. F., Albanese, J., Malledant, Y., Pottecher, J., Lefrant, J. Y., Jaber, S., Joannes-Boyau, O., Orban, C., Ostermann, M., McKenzie, C., Berry, W., Smith, J., Lei, K., Rubulotta, F., Gordon, A., Brett, S., Stotz, M., Templeton, M., Ebm, C., Moran, C., Pettilä, V., Xristodoulou, A., Theodorou, V., Kouliatsis, G., Sertaridou, E., Anthopoulos, G., Choutas, G., Rantis, T., Karatzas, S., Balla, M., Papanikolaou, M., Myrianthefs, P., Gavala, A., Fildisis, G., Koutsoukou, A., Kyriakopoulou, M., Petrochilou, K., Kompoti, M., Michalia, M., Clouva-Molyvdas, F. M., Gkiokas, G., Nikolakopoulos, F., Psychogiou, V., Malliotakis, P., Akoumianaki, E., Lilitsis, E., Koulouras, V., Nakos, G., Kalogirou, M., Komnos, A., Zafeiridis, T., Chaintoutis, C., Arvaniti, K., Matamis, D., Kydona, C., Gritsi-Gerogianni, N., Giasnetsova, T., Giannakou, M., Soultati, I., Chytas, I., Antoniadou, E., Antipa, E., Lathyris, D., Koukoubani, T., Paraforou, T., Spiropoulou, K., Bekos, V., Spring, A., Kalatzi, T., Nikolaou, H., Laskou, M., Strouvalis, I., Aloizos, S., Kapogiannis, S., Soldatou, O., Adembri, C., Villa, G., Giarratano, A., Raineri, S. M., Cortegiani, A., Montalto, F., Strano, M. T., Ranieri, V. M., Sandroni, C., De Pascale, G., Molin, A., Pelosi, P., Montagnani, L., Urbino, R., Mastromauro, I., DeRosa, F. G., Cardoso, T., Afonso, S., Gonçalves-Pereira, J., Baptista, J. P., Özveren, A., Roberts JA, Lipman J, Starr T, Wallis SC, Paul S, Ribas AM, De Waele JJ, DeCrop L, Spapen H, Wauters J, Dugernier T, Jorens P, Dapper I, De Backer D, Taccone FS, Rello J, Ruano L, Afonso E, Alvarez-Lerma F, Gracia-Arnillas MP, Fernández F, Feijoo N, Bardolet N, Rovira A, Garro P, Colon D, Castillo C, Fernado J, Lopez MJ, Fernandez JL, Arribas AM, Teja JL, Ots E, Montejo JC, Catalan M, Prieto I, Gonzalo G, Galvan B, Blasco MA, Meyer E, Nogal FD, Vidaur L, Sebastian R, Garde PM, Velasco Mdel M, Crespo RZ, Esperatti M, Torres A, Montravers P, Baldesi O, Dupont H, Mahjoub Y, Lasocki S, Constantin JM, Payen JF, Martin C, Albanese J, Malledant Y, Pottecher J, Lefrant JY, Jaber S, Joannes-Boyau O, Orban C, Ostermann M, McKenzie C, Berry W, Smith J, Lei K, Rubulotta F, Gordon A, Brett S, Stotz M, Templeton M, Rhodes A, Ebm C, Moran C, Kaukonen KM, Pettilä V, Dimopoulos G, Koulenti D, Xristodoulou A, Theodorou V, Kouliatsis G, Sertaridou E, Anthopoulos G, Choutas G, Rantis T, Karatzas S, Balla M, Papanikolaou M, Myrianthefs P, Gavala A, Fildisis G, Koutsoukou A, Kyriakopoulou M, Petrochilou K, Kompoti M, Michalia M, Clouva-Molyvdas FM, Gkiokas G, Nikolakopoulos F, Psychogiou V, Malliotakis P, Akoumianaki E, Lilitsis E, Koulouras V, Nakos G, Kalogirou M, Komnos A, Zafeiridis T, Chaintoutis C, Arvaniti K, Matamis D, Kydona C, Gritsi-Gerogianni N, Giasnetsova T, Giannakou M, Soultati I, Chytas I, Antoniadou E, Antipa E, Lathyris D, Koukoubani T, Paraforou T, Spiropoulou K, Bekos V, Spring A, Kalatzi T, Nikolaou H, Laskou M, Strouvalis I, Aloizos S, Kapogiannis S, Soldatou O, Bassetti M, Adembri C, Villa G, Giarratano A, Raineri SM, Cortegiani A, Montalto F, Strano MT, Ranieri VM, Sandroni C, De Pascale G, Molin A, Pelosi P, Montagnani L, Urbino R, Mastromauro I, DeRosa FG, Cardoso T, Afonso S, Gonçalves-Pereira J, Baptista JP, Akova M, Özveren A, Hôpital Nord [CHU - APHM], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Roberts, J.A., Stove, V., De Waele, J.J., Sipinkoski, B., McWhinney, B., Ungerer, J.P.J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, K.-M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Starr, T., Wallis, S.C., Lipman, J., Paul, S., Ribas, A.M., DeCrop, L., Spapen, H., Wauters, J., Dugernier, T., Jorens, P., Dapper, I., De Backer, D., Taccone, F.S., Ruano, L., Afonso, E., Alvarez-Lerma, F., Gracia-Arnillas, M.P., Fernández, F., Feijoo, N., Bardolet, N., Rovira, A., Garro, P., Colon, D., Castillo, C., Fernado, J., Lopez, M.J., Fernandez, J.L., Arribas, A.M., Teja, J.L., Ots, E., Montejo, J.C., Catalan, M., Prieto, I., Gonzalo, G., Galvan, B., Blasco, M.A., Meyer, E., Nogal, F.D., Vidaur, L., Sebastian, R., Garde, P.M., Velasco Mdel, M., Crespo, R.Z., Esperatti, M., Torres, A., Baldesi, O., Dupont, H., Mahjoub, Y., Lasocki, S., Constantin, J.M., Payen, J.F., Albanese, J., Malledant, Y., Pottecher, J., Lefrant, J.Y., Jaber, S., Joannes-Boyau, O., Orban, C., Ostermann, M., McKenzie, C., Berry, W., Smith, J., Lei, K., Rubulotta, F., Gordon, A., Brett, S., Stotz, M., Templeton, M., Ebm, C., Moran, C., Pettilä, V., Xristodoulou, A., Theodorou, V., Kouliatsis, G., Sertaridou, E., Anthopoulos, G., Choutas, G., Rantis, T., Karatzas, S., Balla, M., Papanikolaou, M., Myrianthefs, P., Gavala, A., Fildisis, G., Koutsoukou, A., Kyriakopoulou, M., Petrochilou, K., Kompoti, M., Michalia, M., Clouva-Molyvdas, F.M., Gkiokas, G., Nikolakopoulos, F., Psychogiou, V., Malliotakis, P., Akoumianaki, E., Lilitsis, E., Koulouras, V., Nakos, G., Kalogirou, M., Komnos, A., Zafeiridis, T., Chaintoutis, C., Arvaniti, K., Matamis, D., Kydona, C., Gritsi-Gerogianni, N., Giasnetsova, T., Giannakou, M., Soultati, I., Chytas, I., Antoniadou, E., Antipa, E., Lathyris, D., Koukoubani, T., Paraforou, T., Spiropoulou, K., Bekos, V., Spring, A., Kalatzi, T., Nikolaou, H., Laskou, M., Strouvalis, I., Aloizos, S., Kapogiannis, S., Soldatou, O., Adembri, C., Villa, G., Giarratano, A., Raineri, S.M., Cortegiani, A., Montalto, F., Strano, M.T., Ranieri, V.M., Sandroni, C., De Pascale, G., Molin, A., Pelosi, P., Montagnani, L., Urbino, R., Mastromauro, I., DeRosa, F.G., Cardoso, T., Afonso, S., Gonçalves-Pereira, J., Baptista, J.P., Özveren, A., and İç Hastalıkları

Subjects
Male, validity, validation proce, International Cooperation, Settore MED/41 - Anestesiologia, drug protein binding, Gastroenterology, law.invention, Plasma, Staphylococcus infection, Critically ill patients, Interquartile range, law, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Antibiotics, antibiotic therapy, Pharmacology (medical), Pharmacology & Pharmacy, Glycopeptides, Hypoalbuminaemia, ICU, Pharmacokinetics, Adult, Aged, Anti-Bacterial Agents, Chromatography, Critical Illness, Female, Humans, Middle Aged, Protein Binding, Teicoplanin, Young Adult, Drug Monitoring, Microbiology (medical), Infectious Diseases, clinical article, medicine.diagnostic_test, drug dose regimen, critical illne, Medicine (all), article, clinical trial, General Medicine, trough time concentration, drug protein binding variability, Intensive care unit, Glycopeptides, Antibiotics, Critically ill patients, Pharmacokinetics, Hypoalbuminaemia, ICU, 3. Good health, antiinfective agent, drug distribution, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, priority journal, multicenter study (topic), Vancomycin, blood sampling, Critically ill patient, Human, medicine.drug, medicine.medical_specialty, high performance liquid chromatography, area under the curve, ultraviolet spectroscopy, mid dose concentration, chemistry, Glycopeptide, Microbiology, teicoplanin, adult, enterococcal infection, young adult, Adult, drug clearance, Therapeutic index, Internal medicine, Anti-Bacterial Agent, medicine, steady state, Dosing, business.industry, drug half life, Antibiotic, recommended drug dose, calibration, Surgery, multicenter study, Therapeutic drug monitoring, drug blood level, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, free plasma drug concentration, business, metabolism
Abstract

The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The following are the median (interquartile range) total and free concentrations (mg/L): midpoint, total 13.6(11.2-26.0) and free 1.5 (0.7-2.5); trough, total 11.9 (10.2-22.7) and free 1.8 (0.6-2.6). The percentage free teicoplanin for the mid-dose and trough time points was 6.9% (4.5-15.6%) and 8.2% (5.5-16.4%), respectively. The correlation between total and free antibiotic concentrations was moderate for both the midpoint (rho=0.79, P = 0.0021) and trough (rho = 0.63, P = 0.027). Only 42% and 58% of patients were in the lower and higher therapeutic ranges, respectively. In conclusion, use of standard dosing for teicoplanin leads to inappropriate concentrations in a high proportion of critically ill patients. Variability in teicoplanin protein binding is very high, placing significant doubt on the validity of total concentrations for therapeutic drug monitoring in critically ill patients. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Published
2014

271. Nuclear astrophysics with radioactive ions at FAIR

Author

Reifarth, R, primary, Altstadt, S, additional, Göbel, K, additional, Heftrich, T, additional, Heil, M, additional, Koloczek, A, additional, Langer, C, additional, Plag, R, additional, Pohl, M, additional, Sonnabend, K, additional, Weigand, M, additional, Adachi, T, additional, Aksouh, F, additional, Al-Khalili, J, additional, AlGarawi, M, additional, AlGhamdi, S, additional, Alkhazov, G, additional, Alkhomashi, N, additional, Alvarez-Pol, H, additional, Alvarez-Rodriguez, R, additional, Andreev, V, additional, Andrei, B, additional, Atar, L, additional, Aumann, T, additional, Avdeichikov, V, additional, Bacri, C, additional, Bagchi, S, additional, Barbieri, C, additional, Beceiro, S, additional, Beck, C, additional, Beinrucker, C, additional, Belier, G, additional, Bemmerer, D, additional, Bendel, M, additional, Benlliure, J, additional, Benzoni, G, additional, Berjillos, R, additional, Bertini, D, additional, Bertulani, C, additional, Bishop, S, additional, Blasi, N, additional, Bloch, T, additional, Blumenfeld, Y, additional, Bonaccorso, A, additional, Boretzky, K, additional, Botvina, A, additional, Boudard, A, additional, Boutachkov, P, additional, Boztosun, I, additional, Bracco, A, additional, Brambilla, S, additional, Monago, J Briz, additional, Caamano, M, additional, Caesar, C, additional, Camera, F, additional, Casarejos, E, additional, Catford, W, additional, Cederkall, J, additional, Cederwall, B, additional, Chartier, M, additional, Chatillon, A, additional, Cherciu, M, additional, Chulkov, L, additional, Coleman-Smith, P, additional, Cortina-Gil, D, additional, Crespi, F, additional, Crespo, R, additional, Cresswell, J, additional, Csatlós, M, additional, Déchery, F, additional, Davids, B, additional, Davinson, T, additional, Derya, V, additional, Detistov, P, additional, Fernandez, P Diaz, additional, DiJulio, D, additional, Dmitry, S, additional, Doré, D, additional, Dueñas, J, additional, Dupont, E, additional, Egelhof, P, additional, Egorova, I, additional, Elekes, Z, additional, Enders, J, additional, Endres, J, additional, Ershov, S, additional, Ershova, O, additional, Fernandez-Dominguez, B, additional, Fetisov, A, additional, Fiori, E, additional, Fomichev, A, additional, Fonseca, M, additional, Fraile, L, additional, Freer, M, additional, Friese, J, additional, Borge, M G., additional, Redondo, D Galaviz, additional, Gannon, S, additional, Garg, U, additional, Gasparic, I, additional, Gasques, L, additional, Gastineau, B, additional, Geissel, H, additional, Gernhäuser, R, additional, Ghosh, T, additional, Gilbert, M, additional, Glorius, J, additional, Golubev, P, additional, Gorshkov, A, additional, Gourishetty, A, additional, Grigorenko, L, additional, Gulyas, J, additional, Haiduc, M, additional, Hammache, F, additional, Harakeh, M, additional, Hass, M, additional, Heine, M, additional, Hennig, A, additional, Henriques, A, additional, Herzberg, R, additional, Holl, M, additional, Ignatov, A, additional, Ignatyuk, A, additional, Ilieva, S, additional, Ivanov, M, additional, Iwasa, N, additional, Jakobsson, B, additional, Johansson, H, additional, Jonson, B, additional, Joshi, P, additional, Junghans, A, additional, Jurado, B, additional, Körner, G, additional, Kalantar, N, additional, Kanungo, R, additional, Kelic-Heil, A, additional, Kezzar, K, additional, Khan, E, additional, Khanzadeev, A, additional, Kiselev, O, additional, Kogimtzis, M, additional, Körper, D, additional, Kräckmann, S, additional, Kröll, T, additional, Krücken, R, additional, Krasznahorkay, A, additional, Kratz, J, additional, Kresan, D, additional, Krings, T, additional, Krumbholz, A, additional, Krupko, S, additional, Kulessa, R, additional, Kumar, S, additional, Kurz, N, additional, Kuzmin, E, additional, Labiche, M, additional, Langanke, K, additional, Lazarus, I, additional, Bleis, T Le, additional, Lederer, C, additional, Lemasson, A, additional, Lemmon, R, additional, Liberati, V, additional, Litvinov, Y, additional, Löher, B, additional, Herraiz, J Lopez, additional, Münzenberg, G, additional, Machado, J, additional, Maev, E, additional, Mahata, K, additional, Mancusi, D, additional, Marganiec, J, additional, Perez, M Martinez, additional, Marusov, V, additional, Mengoni, D, additional, Million, B, additional, Morcelle, V, additional, Moreno, O, additional, Movsesyan, A, additional, Nacher, E, additional, Najafi, M, additional, Nakamura, T, additional, Naqvi, F, additional, Nikolski, E, additional, Nilsson, T, additional, Nociforo, C, additional, Nolan, P, additional, Novatsky, B, additional, Nyman, G, additional, Ornelas, A, additional, Palit, R, additional, Pandit, S, additional, Panin, V, additional, Paradela, C, additional, Parkar, V, additional, Paschalis, S, additional, Pawłowski, P, additional, Perea, A, additional, Pereira, J, additional, Petrache, C, additional, Petri, M, additional, Pickstone, S, additional, Pietralla, N, additional, Pietri, S, additional, Pivovarov, Y, additional, Potlog, P, additional, Prokofiev, A, additional, Rastrepina, G, additional, Rauscher, T, additional, Ribeiro, G, additional, Ricciardi, M, additional, Richter, A, additional, Rigollet, C, additional, Riisager, K, additional, Rios, A, additional, Ritter, C, additional, Frutos, T Rodriguez, additional, Vignote, J Rodriguez, additional, Röder, M, additional, Romig, C, additional, Rossi, D, additional, Roussel-Chomaz, P, additional, Rout, P, additional, Roy, S, additional, Söderström, P, additional, Sarkar, M Saha, additional, Sakuta, S, additional, Salsac, M, additional, Sampson, J, additional, Sanchez, J, additional, Saez, del Rio, additional, Rosado, J Sanchez, additional, Sanjari, S, additional, Sarriguren, P, additional, Sauerwein, A, additional, Savran, D, additional, Scheidenberger, C, additional, Scheit, H, additional, Schmidt, S, additional, Schmitt, C, additional, Schnorrenberger, L, additional, Schrock, P, additional, Schwengner, R, additional, Seddon, D, additional, Sherrill, B, additional, Shrivastava, A, additional, Sidorchuk, S, additional, Silva, J, additional, Simon, H, additional, Simpson, E, additional, Singh, P, additional, Slobodan, D, additional, Sohler, D, additional, Spieker, M, additional, Stach, D, additional, Stan, E, additional, Stanoiu, M, additional, Stepantsov, S, additional, Stevenson, P, additional, Strieder, F, additional, Stuhl, L, additional, Suda, T, additional, Sümmerer, K, additional, Streicher, B, additional, Taieb, J, additional, Takechi, M, additional, Tanihata, I, additional, Taylor, J, additional, Tengblad, O, additional, Ter-Akopian, G, additional, Terashima, S, additional, Teubig, P, additional, Thies, R, additional, Thoennessen, M, additional, Thomas, T, additional, Thornhill, J, additional, Thungstrom, G, additional, Timar, J, additional, Togano, Y, additional, Tomohiro, U, additional, Tornyi, T, additional, Tostevin, J, additional, Townsley, C, additional, Trautmann, W, additional, Trivedi, T, additional, Typel, S, additional, Uberseder, E, additional, Udias, J, additional, Uesaka, T, additional, Uvarov, L, additional, Vajta, Z, additional, Velho, P, additional, Vikhrov, V, additional, Volknandt, M, additional, Volkov, V, additional, von Neumann-Cosel, P, additional, von Schmid, M, additional, Wagner, A, additional, Wamers, F, additional, Weick, H, additional, Wells, D, additional, Westerberg, L, additional, Wieland, O, additional, Wiescher, M, additional, Wimmer, C, additional, Wimmer, K, additional, Winfield, J S, additional, Winkel, M, additional, Woods, P, additional, Wyss, R, additional, Yakorev, D, additional, Yavor, M, additional, Cardona, J Zamora, additional, Zartova, I, additional, Zerguerras, T, additional, Zgura, M, additional, Zhdanov, A, additional, Zhukov, M, additional, Zieblinski, M, additional, Zilges, A, additional, and Zuber, K, additional

Published
2016
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272. Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae.

Author

Bossé, JT, Li, Y, Walker, S, Atherton, T, Fernandez Crespo, R, Williamson, SM, Rogers, J, Chaudhuri, RR, Weinert, LA, Oshota, O, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR, BRaDP1T Consortium, Bossé, JT, Li, Y, Walker, S, Atherton, T, Fernandez Crespo, R, Williamson, SM, Rogers, J, Chaudhuri, RR, Weinert, LA, Oshota, O, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR, and BRaDP1T Consortium

Abstract

OBJECTIVES: The objective of this study was to determine the distribution and genetic basis of trimethoprim resistance in Actinobacillus pleuropneumoniae isolates from pigs in England. METHODS: Clinical isolates collected between 1998 and 2011 were tested for resistance to trimethoprim and sulphonamide. The genetic basis of trimethoprim resistance was determined by shotgun WGS analysis and the subsequent isolation and sequencing of plasmids. RESULTS: A total of 16 (out of 106) A. pleuropneumoniae isolates were resistant to both trimethoprim (MIC >32 mg/L) and sulfisoxazole (MIC ≥256 mg/L), and a further 32 were resistant only to sulfisoxazole (MIC ≥256 mg/L). Genome sequence data for the trimethoprim-resistant isolates revealed the presence of the dfrA14 dihydrofolate reductase gene. The distribution of plasmid sequences in multiple contigs suggested the presence of two distinct dfrA14-containing plasmids in different isolates, which was confirmed by plasmid isolation and sequencing. Both plasmids encoded mobilization genes, the sulphonamide resistance gene sul2, as well as dfrA14 inserted into strA, a streptomycin-resistance-associated gene, although the gene order differed between the two plasmids. One of the plasmids further encoded the strB streptomycin-resistance-associated gene. CONCLUSIONS: This is the first description of mobilizable plasmids conferring trimethoprim resistance in A. pleuropneumoniae and, to our knowledge, the first report of dfrA14 in any member of the Pasteurellaceae. The identification of dfrA14 conferring trimethoprim resistance in A. pleuropneumoniae isolates will facilitate PCR screens for resistance to this important antimicrobial.

Published
2015

273. Maternidade

Author

Lenita Crespo R. Ferraz de Sampaio

Subjects
pintura, acrílico em tela, lcsh:R, lcsh:Medicine
Published
2013

274. De médico e louco

Author

Lenita Crespo R. F. de Sampaio

Subjects
lcsh:R, lcsh:Medicine
Published
2013

275. General model for explicitly hole-doped superconductor parent compounds: Electronic structure of Ca2-xNaxCuO2Cl2 as a case study

Author

RIVERO, P, MOREIRA, IDPR, GRAU-CRESPO, R, DATTA, SN, and ILLAS, F

Subjects
Density-Functional Theory, Cuprate Superconductors, Augmented-Wave Method, Systems, Ca2cuo2cl2, High-Tc Superconductivity, Sr2cuo2cl2, Exchange, La2cuo4, Spectra
Abstract

Periodic density functional theory (DFT) + U calculations using sufficiently large supercells to explicitly account for dopant disorder are reported for undoped Ca2CuO2Cl2 and for the doped Ca2-xNaxCuO2Cl2 (x = 0.125 and x = 0.250). For the undoped material, the charge-transfer antiferromagnetic character is properly reproduced. For the doped systems, a metallic character is predicted with the conduction band dominated by the O(2p) states, with doping having a small effect on the antiferromagnetic order of the Cu2+ cations within the CuO2 planes while maintaining the diamagnetic character in the rest of centers. The analysis of the spin density plots for the doped material evidences the appearance of a new feature reminiscent of the so-called Zhang-Rice singlet, thus providing unbiased independent support to the corresponding model Hamiltonian. However, it is also worth pointing out that the present DFT picture provides only an average static representation of what is expected to be a dynamic electronic structure.

Published
2013

276. [Untitled]

Author

Bremmer, R.H., Porck, M.H., Onderdelinden, S., Jacobs, J.G.A.M., Smith, P.J., Crespo, R., Wilbers, U., and Walthaus, C.

Published
2013

277. Assessing natural infection with Zika virus in the southern house mosquito, Culex quinquefasciatus, during 2016 in Puerto Rico.

Author

YEE, D. A., DEJESUS‐CRESPO, R., HUNTER, F. F., and BAI, F.

Subjects
*ZIKA virus, *CULEX quinquefasciatus, *MYALGIA, *VERTICAL transmission (Communicable diseases), *INSECT trapping, *VIRAL transmission
Abstract

Abstract: The epidemic of Zika in the Western hemisphere has led to intense investigations of all species important in the transmission of Zika virus (ZikV), including putative mosquito vectors. Although evidence points to Stegomyia (= Aedes) (Diptera: Culicidae) mosquitoes as the primary vectors in nature among humans, there remains the possibility that other common mosquito species may be implicated in the rapid spread of the virus. Herein, field‐caught Culex quinquefasciatus (Diptera: Culicidae) collected during June 2016 in different neighbourhoods in San Juan, Puerto Rico were examined for the presence of natural infection with ZikV. Stegomyia aegypti (= Aedes aegypti) from the same locations were also analysed. None of the Cx. quinquefasciatus tested showed natural infection for ZikV, whereas S. aegypti tested positive at seven sites. The present results suggest that Cx. quinquefasciatus was not involved in the transmission of ZikV in San Juan, Puerto Rico in 2016. [ABSTRACT FROM AUTHOR]

Published
2018
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278. A personal knowledge management metamodel based on semantic analysis and social information.

Author

López-Quintero, J. F., Cueva Lovelle, J. M., González Crespo, R., and García-Díaz, V.

Subjects
KNOWLEDGE management, SEMANTICS, SOCIAL informatics, ONLINE social networks, MACHINE learning
Abstract

This article describes the development of a functional architecture for personal knowledge management (PKM), defined from the lessons-learnt concept registered in a mass-use social network analyzed with an algorithm of machine learning. This functional architecture applies, in practical manner, the implementation of a registry system of the personal lessons learnt in the cloud through a Facebook social network. The process starts by acquiring data from the connection to a non-relational database (NoSql) in Amazon’s SimpleDB and to which a complementary analysis algorithm of machine learning has been configured for the semantic analysis of the information registered from lessons learnt and, thus, to study the generation of organizational knowledge management from PKM. The result is the design of a functional architecture that permits integrating the Web 2.0 application and a semantic analysis algorithm from unstructured information by applying machine learning techniques. [ABSTRACT FROM AUTHOR]

Published
2018
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279. Estenosis esofágica en un perro. Resolución endoscópica

Author

Crespo, R., Gil, A., and Ayala, I.

Subjects
Álcali, Alkali, Dilatación con balón, Esophagoscopy, Estenosis esofágica, Esofagoscopia, Balloon dilation, Esophageal stricture
Abstract

Un perro de 3 años de edad, macho, raza Pomerania, es remitido al Hospital Clínico Veterinario con signos de disfagia esofágica desde hace tres días, coincidiendo con la aparición de una botella de fertilizante mordida. El fertilizante es un álcali. La analítica sanguínea, la radiografía simple torácica y el esofagograma de contraste torácico no evidencian alteraciones. Se realiza la esofagoscopia y el diagnóstico definitivo es estenosis esofágica, acompañada de inflamación y un grado grave de daño en la mucosa. Como terapéutica para resolver la estenosis se lleva a cabo el tratamiento de elección, que es la dilatación con balón guiada endoscópicamente, donde se realizan varias dilataciones con el mismo procedimiento. Posteriormente, se instaura un tratamiento médico-dietético para resolver la inflamación esofágica y conseguir la recuperación sistémica del animal. La evolución del paciente es favorable, dejando de presentar los signos clínicos, aunque se mantiene un tratamiento dietético a base de dieta húmeda. En este artículo se incluye un caso completo de una de las causas propuestas como posibles desencadenantes de estenosis esofágica o, al menos, de esofagitis grave.

Published
2012

280. Moisture dependence on mechanical properties of pine nuts from Pinus pinea L

Author

Cárcel, L. M., Bon Corbín, José, Acuna, Luis, Nevares, Ignacio, Del Álamo Sanza, María, and Crespo, R.

Subjects
TECNOLOGIA DE ALIMENTOS, Pine nut, Mechanical properties, Moisture
Abstract

[EN] Mechanical properties of pine nut shell are very important in the cracking process. Before industrial cracking shell moisture is adjusted by water soaking in order to avoid the breaking up of the nuts. In this work the moisture dependence of the mechanical properties of pine nut shells were studied in order to improve the industrial cracking process. Relationship between nut size and moisture content was studied and no significant differences were found for shell dimensions at four different moisture levels, 9.79%, 16.71%, 20.98% and 25.05% (dry basis). Compression tests were carried out on pine nuts at nine different moisture contents between 1.38% and 25.48% (db) and their main mechanical parameters were evaluated. Nut shell has a characteristic behavior under compression loading. Rupture force, rupture deformation, elasticity and rupture energy of shell were found to be moisture dependent. Values of rupture force decreased linearly from 0.24 to 0.49 kN, rupture deformation and rupture energy increased initially with moisture until stabilization at asymptotic values of about 1.8 mm and 0.22 J, respectively. Elasticity index of the shell decreased linearly with moisture from 1 to 0.4 kN/mm. (C) 2011 Elsevier Ltd. All rights reserved.

Published
2012

281. O papel do eletrocardiograma no diagnóstico da Miocardiopatia Takotsubo

Author

Crespo, R, Paulino, R, Bernardo, R, and Raposo, N

Subjects
Electrocardiografia, Cardiomiopatia de Takotsubo
Abstract

A Miocardiopatia Takotsubo (MT) ocorre maioritariamente em doentes idosos do género feminino, com associação causal a fatores de stress emocional ou físico. O stress poderá provocar elevações nos níveis de catecolaminas e hiperexpressividade do sistema nervoso simpático, resultando num quadro semelhante a stunning miocárdico neurogénico, onde ocorre “balonamento” dos segmentos meso‐apicais do ventrículo esquerdo (VE). Este traduz‐se em alterações da cinética das paredes do VE e é identificado por ecocardiografia ou ventriculografia. A coronariografia, tipicamente, revela ausência de estenose superior a 50%, oclusões do lúmen ou rutura de placa, mas a apresentação clínica na fase aguda é sugestiva de Síndrome Coronário Agudo (SCA) e o eletrocardiograma (ECG) apresenta alterações sugestivas de Enfarte Agudo do Miocárdio (EAM) anterior. Os achados mais comuns são o supradesnivelamento do segmento ST e inversão da onda T nas derivações pré‐cordiais. Alterações de repolarização nas derivações inferiores ou laterais, ausência de alterações eletrocardiográficas, bloqueio de ramo de novo, taquicardia ventricular (TV) ou fibrilhação ventricular (FV) podem ocorrer, ainda que com menor frequência. O supradesnivelamento do segmento ST reverte ao fim de poucos dias, mas persistem ondas T negativas e um prolongamento do intervalo QT com duração que pode ir até quatro meses. Este prolongamento do intervalo QT indicia um maior risco de disritmias ventriculares malignas em doentes com vulnerabilidade por QT longo prévio. Assim, o ECG tem utilidade limitada no diagnóstico da MT, mas permite avaliar a sua evolução e identificar os doentes em risco de desenvolver arritmias malignas

Published
2012

282. Resonant breakup of C19 on a proton target

Author

Crespo, R., Rodríguez Gallardo, Manuela, Moro, A.M., Deltuva, A. Cravo, E., and Fonseca, A.C.

Subjects
Nuclear Theory, Nuclear Experiment
Abstract

The resonant breakup of C19 on a proton target at 70 MeV/nucleon is analyzed using Faddeev-Alt, Grassberger, Sandhas (Faddeev-AGS) and continuum-discretized coupled-channels (CDCC) reaction frameworks, where in both cases a three-body model (18C+n+p) for the reaction is considered. Taking a C18 + p potential from a global nucleon-nucleus parametrization and a L-independent Gaussian proton-neutron potential, both methods provide very similar results for the calculated observables. However, when this simplified proton-neutron potential is replaced by the more realistic CD-Bonn potential, the breakup cross section, calculated with the Faddeev AGS formalism, decreases by almost one order of magnitude, largely underestimating the experimental data. From this calculation, we conclude that, within a core + valence neutron model, the single-particle mechanism gives a negligible contribution to the calculated resonant breakup and therefore core-excitation mechanisms should be taken into account. © 2011 American Physical Society., We are grateful to Y. Satou for providing us the experimental data in tabular form. The authors are supported by the FCT Grants PTDC/FIS/65736/2006 and PTDC/FIS/103902/2008, the Complementary Action Portugal-Spain PORT2008-05, and the Spanish Ministerio de Ciencia e Innovacion under Project FPA2009-07653.

Published
2011

286. Involuntary outpatient treatment (IOT) in Spain

Author

Hernández-Viadel, M., primary, Cañete-Nicolás, C., additional, Bellido-Rodriguez, C., additional, Asensio-Pascual, P., additional, Lera-Calatayud, G., additional, Calabuig-Crespo, R., additional, and Leal-Cercós, C., additional

Published
2015
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288. Probing nucleon-nucleon interactions in breakup of a one-neutron halo $^{11}$Be on a proton target

Author

Cravo, E., Crespo, R., Moro, A. M., and Deltuva, A.

Subjects
Nuclear Theory (nucl-th), Nuclear Theory, FOS: Physical sciences, Nuclear Experiment
Abstract

A comparison between full few-body Faddeev/Alt-Grassberger-Sandhas (Faddeev/AGS) and continuum-discretized coupled channels (CDCC) calculations is made for the resonant and nonresonant breakup of $^{11}$Be on proton target at 63.7 MeV/u incident energy. A simplified two-body model is used for $^{11}$Be which involves an inert $^{10}$Be(0$^+$) core and a valence neutron. The sensitivity of the calculated observables to the nucleon-nucleon potential dynamical input is analysed. We show that with the present NN and N-core dynamics the results remain a puzzle for the few-body problem of scattering from light exotic halo nuclei., To be published Phys Rev Rapid Communication

Published
2010

289. Thermochemistry of strontium incorporation in aragonite from atomistic simulations

Author

Grau-Crespo, R., Ruiz-Hernández, S. E., Ruiz-Salvador, A. R., and De Leeuw, N. H.

Subjects
Coral reefs, Aragonite, Strontium, Thermodynamic activity
Abstract

We have investigated the thermodynamics of mixing between aragonite (orthorhombic CaCO3) and strontianite (SrCO3). In agreement with experiment, our simulations predict that there is a miscibility gap between the two solids at ambient conditions. All SrxCa1 xCO3 solids with compositions 0.12 < x < 0.87 are metastable with respect to separation into a Ca-rich and a Sr-rich phase. The concentration of Sr in coral aragonites (x 0.01) lies in the miscibility region of the phase diagram, and therefore formation of separated Sr-rich phases in coral aragonites is not thermodynamically favorable. The miscibility gap disappears at around 380 K. The enthalpy of mixing, which is positive and nearly symmetric with respect to x = 0.5, is the dominant contribution to the excess free energy, while the vibrational and configurational entropic contributions are small and of opposite sign. We provide a detailed comparison of our simulation results with available experimental data. Se investigó la actividad termodinámica existente entre la mezcla de la aragonita y el estroncio. Se ofrecen todos los datos experimentales y los resultados de la simulación efectuada predicen que hay un vacío en condiciones de ambiente. Published aragonita, estroncio, arrecife de coral, actividad termodinámica

Published
2010

290. Thermodynamics of hydrogen vacancies in MgH2 from first-principles calculations and grand-canonical statistical mechanics

Author

Grau-Crespo, R., Smith, K. C., Fisher, T. S., de Leeuw, N. H., and Waghmare, U. V.

Subjects
Condensed Matter - Materials Science, Condensed Matter::Materials Science, ab initio calculations, hydrogen, hydrogen storage, magnesium compounds, statistical mechanics, thermodynamics, vacancies (crystal), Statistical Mechanics (cond-mat.stat-mech), Physics::Atomic and Molecular Clusters, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Condensed Matter - Statistical Mechanics, Nanoscience and Nanotechnology
Abstract

Ab initio calculations and statistical mechanics are combined to elucidate the thermodynamics of H vacancies in MgH2. A general method based on a grand-canonical ensemble of defect configurations is introduced to model the exchange of hydrogen between crystalline MgH2 and gas-phase H2. We find that, at temperatures and hydrogen partial pressures of practical interest, MgH2 is capable of accommodating only very small concentrations of hydrogen vacancies, which consist mainly of isolated defects rather than vacancy clusters, contrary to what is expected from a simple energetic analysis., 13 pages, 5 figures. Paper accepted in Physical Review B

Published
2009

291. Reflujo vesicoureteral bilateral grave y nefropatía renal en pacientes varones recién nacidos: Síndrome de válvulas-Like o Micción no coordinada en el feto varón

Author

Rafael Luque Mialdea and Martín-Crespo R

Subjects
Gynecology, medicine.medical_specialty, business.industry, Urology, Medicine, General Medicine, business
Abstract

OBJETIVOS Diversos trabajos se han publicado en la ultima decada, que diferencian el reflujo vesico ureteral (RVU) neonatal con afectacion grave renal, de otro grupo mayoritario de neonatos con RVU neonatal sin lesion renal y los diagnosticados en edades mas tardias generalmente relacionados con infeccion urinaria (ITU). Conviniendo en que el RVU forma parte de un amplio espectro tanto en la expresion clinica como por lo tanto de su patogenesis, se han descrito diversas teorias para explicar la existencia de este tipo de RVU congenito en varones. La existencia de una malfuncion vesico uretral fetal, expresada postnatalmente con una vejiga de alto riesgo, definida esta mediante estudio urodinamico en el 1o trimestre de vida extrauterina, explica la aparicion de RVU grave fetal con afectacion funcional de una o ambas unidades renales ya en el recien nacido y que precisa de su reconocimiento para un adecuado planteamiento terapeutico, este cuadro lo hemos caracterizado como Sindrome de Valvulas-Like o Miccion no coordinada fetal en el varon.

Published
2008

292. Spectroscopy of the unbound: One-neutron knockout reaction of $^{14}$Be

Author

Crespo, R., Deltuva, A., Rodríguez-Gallardo, M., Cravo, E., and Fonseca, A. C.

Subjects
Nuclear Theory (nucl-th), Nuclear Theory, FOS: Physical sciences, Nuclear Experiment
Abstract

Full Faddeev-type calculations are performed for one-neutron knockout reaction of $^{14}$Be on proton target at 69 MeV/u incident energy. Inclusive transverse momentum distributions for the outgoing ($^{12}$Be + n) system and semi-inclusive cross sections are presented. A significant proton-core single scattering contribution emerges where the valence neutron has non zero angular momentum relative to the core. This indicates that distorted-wave impulse approximation is inadequate and the complete multiple scattering series must be taken into account for the considered reaction. The magnitude of the semi-inclusive cross section at quasifree scattering conditions is a clear signature of the angular momentum of the valence nucleon., Comment: To be published in Published in Phys Rev C

Published
2008
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293. Redox Behavior of the Model Catalyst Pd/CeO 2− x /Pt(111)

Author

Wilson , E. L., Grau-Crespo , R., Pang , C. L., Cabailh , Gregory, Chen , Q., Purton , J. A., Catlow , C. R. A., Brown , W. A., de Leeuw , N. H., Thornton , G., London Centre for Nanotechnology, and University College of London [London] ( UCL )

Subjects
[ PHYS ] Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

297. Estado actual del abordaje retroperitoneoscópico en en urología pediátrica

Author

Luis A. Díaz, L Moreno, C Carrero, Martín-Crespo R, and Rafael Luque Mialdea

Subjects
business.industry, Abordaje retroperitoneal laparoscópico, Urology, Pieloplastia, General Medicine, Retroperitoneoscopia, Edad pediatrica, Medicine, Historia retroperitoneoscopia, Nefrectomía, business, Humanities, Infantil, Cirugía robótica
Abstract

La retroperitoneoscopia urológica pediátrica presenta tres etapas diferenciadas que han condicionado su desarrollo, aunque no impedido: 1) limitadas indicaciones en la edad pediátrica, debido a que la cirugía pediátrica convencional se caracteriza por ser poco invasiva; 2) adecuación del desarrollo tecnológico realizado en el adulto a la edad pediátrica; 3) superar las controversias entre cirujanos pediátricos y no laparoscopistas. Tras superar ésta etapa, la retroperitoneoscopia se ha impuesto como herramienta imprescindible para el tratamiento de las diversas patologías de la celda renal, siendo de las indicaciones ablativos la nefrectomía su "gold estándar", y de las reconstructivas la pieloplastia, por abordaje retroperitoneoscopico completo o asistido.

Published
2007

298. P0601 - Verfahren zur Kontrolle von Bestrahlungen an Bestrahlungseinrichtungen mit in-beam Positronenemissionstomographen

Author

Crespo, R., Enghardt, W., Fiedler, F., and Heidel, K.

Abstract

Verfahren zur Kontrolle von Bestrahlungen an Bestrahlungseinrichtungen mit in-beam Positronenemissionstomographen, wobei die Mikrostruktur des Strahls verwendet wird, dadurch gekennzeichnet, – dass die Flugzeitdifferenz der Annihilationsquanten gemessen wird und – die Korrelation des Annihilationsortes mit den Strahlortskoordinaten in ein Echtzeitdatenerfassungssystem eingespeist wird und – aus der Korrelation des Annihilationsortes und der Strahlortskoordinaten und der Mikro- und Makrostruktur des Strahls eine off-line-Korrektur der Abbildungsfehler auf Grund physiologischer Prozesse durch Abtrennung der lang- und kurzlebigen Positronenemitter erfolgt.

Published
2007

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