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251. Interstrand Crosslinking Involving Guanine: A New Major UVC Laser‐Induced Biphotonic Oxidatively Generated DNA Damage†.

Author

Angelov, Dimitar, Lone, Imtiaz Nisar, Menoni, Hervé, and Cadet, Jean

Subjects
IONIZING radiation, DNA, RADICAL cations, LASER pulses, DNA damage, GUANINE
Abstract

Several classes of oxidatively generated DNA damage including oxidized purine and pyrimidine bases, interstrand base crosslinks and DNA‐protein crosslinks have been previously shown to be generated in both isolated DNA and cellular DNA upon exposure to either 266‐nm laser irradiation or one‐electron oxidants. In this study, we provide evidence that biphotonic ionization of guanine bases by UVC laser irradiation of double‐stranded deoxyoligonucleotides in aerated aqueous solutions induces the formation of interstrand crosslinks (ICLs). This is supported by various experiments including sequencing gel analyses of formed photoproducts and effects of UVC laser intensity on their formation. This constitutes a novel example of the diversity of reactions of guanine radical cation that can be generated by various one‐electron oxidants including UVC laser biphotonic ionization, direct effect of ionization radiation and type I photosensitizers. However, the exact structure of the interstrand base adducts that is a challenging analytical issue remains to be further established. Examples of relevant biochemical/structural applications of biphotonic induction of ICLs in DNA samples by high‐intensity UVC laser pulses are provided. [ABSTRACT FROM AUTHOR]

Published
2022
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258. Interplay of intrinsic and environmental effects on the magnetic properties of free radicals issuing from H-atom addition to cytosine

Author

Adamo, Carlo, Heitzmann, Marie, Meilleur, Flora, Rega, Nadia, Scalmani, Giovanni, Grand, Andre, Cadet, Jean, and Barone, Vincenzo

Subjects
Free radical reactions -- Research, Hydrogen -- Research, Chemistry
Abstract

Research into possible radical reaction products issuing from H-atom addition to cytosine is presented. It was found that the 5,6-dihydrocytos-5yl radical is effectively planar, while the 5,6-dihydrocytos-6yl radical has a half-chair conformation at low temperature.

Published
2001

259. Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions

Author

Douki, Thierry and Cadet, Jean

Subjects
DNA damage -- Research, Ultraviolet radiation -- Research, Biological sciences, Chemistry
Abstract

TT and TC bipyrimidine sites are the most reactive sequences to UVB radiation whereas CT and CC seem to be less reactive. Dewar valence isomers are not produced in detectable amounts, nor are cytosine-cytosine photoproducts.

Published
2001

264. Investigating the Long-Range Transport of Aerosol Plumes Following the Amazon Fires (August 2019): A Multi-Instrumental Approach from Ground-Based and Satellite Observations

Author

Bencherif, Hassan, primary, Bègue, Nelson, additional, Kirsch Pinheiro, Damaris, additional, du Preez, David Jean, additional, Cadet, Jean-Maurice, additional, da Silva Lopes, Fábio Juliano, additional, Shikwambana, Lerato, additional, Landulfo, Eduardo, additional, Vescovini, Thomas, additional, Labuschagne, Casper, additional, Silva, Jonatan João, additional, Anabor, Vagner, additional, Coheur, Pierre-François, additional, Mbatha, Nkanyiso, additional, Hadji-Lazaro, Juliette, additional, Sivakumar, Venkataraman, additional, and Clerbaux, Cathy, additional

Published
2020
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266. Increased amphetamine-induced hyperactivity in translin (Tsn) KO mice is driven by elevated adiposity

Author

Fu, Xiuping, primary, Shah, Aparna P., additional, Keighron, Jacqueline, additional, Mou, Ta-Chung M., additional, Ladenheim, Bruce, additional, Alt, Jesse, additional, Fukudome, Daisuke, additional, Niwa, Minae, additional, Tamashiro, Kellie, additional, Tanda, Gianluigi, additional, Sawa, Akira, additional, Cadet, Jean-Lud, additional, Rais, Rana, additional, and Baraban, Jay M., additional

Published
2020
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267. The Lancet NCDI Poverty Commission: bridging a gap in universal health coverage for the poorest billion

Author

Bukhman, Gene, primary, Mocumbi, Ana O, additional, Atun, Rifat, additional, Becker, Anne E, additional, Bhutta, Zulfiqar, additional, Binagwaho, Agnes, additional, Clinton, Chelsea, additional, Coates, Matthew M, additional, Dain, Katie, additional, Ezzati, Majid, additional, Gottlieb, Gary, additional, Gupta, Indrani, additional, Gupta, Neil, additional, Hyder, Adnan A, additional, Jain, Yogesh, additional, Kruk, Margaret E, additional, Makani, Julie, additional, Marx, Andrew, additional, Miranda, J Jaime, additional, Norheim, Ole F, additional, Nugent, Rachel, additional, Roy, Nobhojit, additional, Stefan, Cristina, additional, Wallis, Lee, additional, Mayosi, Bongani, additional, Adjaye-Gbewonyo, Kafui, additional, Adler, Alma, additional, Amegashie, Fred, additional, Amuyunzu-Nyamongo, Mary Kigasia, additional, Arwal, Said Habib, additional, Bassoff, Nicole, additional, Beste, Jason A., additional, Boudreaux, Chantelle, additional, Byass, Peter, additional, Cadet, Jean Roland, additional, Dagnaw, Wubaye Walelgne, additional, Eagan, Arielle Wilder, additional, Feigl, Andrea, additional, Gathecha, Gladwell, additional, Haakenstad, Annie, additional, Haileamlak, Abraham Mitike, additional, Johansson, Kjell Arne, additional, Kamanda, Mamusu, additional, Karmacharya, Biraj, additional, Kasomekera, Noel, additional, Kintu, Alex, additional, Koirala, Bhagawan, additional, Kwan, Gene F., additional, Larco, Nancy Charles, additional, Maongezi, Sarah, additional, Masiye, Jones, additional, Mayige, Mary, additional, McLaughlin, Amy, additional, Memirie, Solomon Tessema, additional, Muquingue, Humberto Nelson, additional, Mwangi, Kibachio Joseph Muiruri, additional, Ndayisaba, Gilles Francois, additional, Noble, Christopher A., additional, Noormal, Bashir, additional, Olsen, Maia, additional, Park, Paul, additional, Aguilar, Gisela Robles, additional, Sankoh, Osman A., additional, Saxena, Akshar, additional, Schwartz, Leah N., additional, Schwarz, Dan K., additional, Shaffer, Jonathan D., additional, Sumner, Andrew P., additional, Doe, Zoe Taylor, additional, Upreti, Senendra Raj, additional, Verguet, Stéphane, additional, Watkins, David, additional, and Wroe, Emily B., additional

Published
2020
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280. Contributors

Author

Aminoff, Michael J., primary, Baehring, Joachim M., additional, Barboi, Alexandru C., additional, Bartt, Russell E., additional, Belman, Anita L., additional, Benarroch, Eduardo, additional, Berg, Bruce O., additional, Bhatia, Sanjay, additional, Bianco, Brian A., additional, Biller, José, additional, Bleck, Thomas P., additional, Boeve, Bradley F., additional, Bolla, Karen I., additional, Bönnemann, Carsten G., additional, Brackmann, Derald E., additional, Brewer, James B., additional, Bromley, Steven M., additional, Brown, Paul, additional, Cadet, Jean Lud, additional, Camicioli, Richard, additional, Campero, Mario S., additional, Caplan, Louis R., additional, Caselli, Richard J., additional, Castillo, José Luis, additional, Cea, Gabriel, additional, Chervin, Ronald D., additional, Chou, Kelvin L., additional, Chung, Chin-Sang, additional, Cochrane, Thomas I., additional, Cohen, Bruce H., additional, Consens, Flavia B., additional, Cummings, Jeffrey L., additional, Dastur, Cyrus K., additional, Diener, Hans Christoph, additional, Doty, Richard L., additional, Dyken, Paul Richard, additional, Evans, Randolph W., additional, Fahn, Stanley, additional, Faro, Scott H., additional, Ferrante, Mark A., additional, Feske, Steven K., additional, Fetterman, Bruce L., additional, Fletcher, Jeffrey J., additional, Foldvary-Schaefer, Nancy, additional, Freeman, Roy, additional, Friedman, Joseph H., additional, Gabrieli, John D.E., additional, Galetta, Steven L., additional, Garbern, James Y., additional, Gascon, Generoso G., additional, Golden, Jeffrey A., additional, Gonzalez-Rothi, Leslie J., additional, Goodwin, James, additional, Griggs, Robert C., additional, Hain, Timothy C., additional, Hammerstad, John P., additional, Heilman, Kenneth M., additional, Hening, Wayne A., additional, Hermanowicz, Neal, additional, Hershey, Beverly L., additional, Hochberg, Fred H., additional, Horn, Stacy S., additional, Jankovic, Joseph, additional, Janus, Todd J., additional, Kaufmann, Horacio, additional, Kinsella, Laurence J., additional, Klockgether, Thomas, additional, Koenigsberg, Robert A., additional, Kompoliti, Katie, additional, Kupsky, William J., additional, LeWitt, Peter A., additional, Liu, Grant T., additional, Love, Betsy B., additional, Maertens, Paul, additional, Maletic-Savatic, Mirjana, additional, Mendez, Mario F., additional, Meriggioli, Matthew N., additional, Mohamed, Feroze B., additional, Nasreddine, Ziad S., additional, Nathan, Barnett R., additional, Newman, Nancy J., additional, Noseworthy, John H., additional, Nutt, John G., additional, Osborne, Benjamin J., additional, Ozand, Pinar T., additional, Pirko, Istvan, additional, Prasad, Sashank, additional, Preston, Alison R., additional, Quant, Eudocia, additional, Riley, David E., additional, Roos, Karen L., additional, Rose, Michael, additional, Rosen, Allyson C., additional, Rowin, Julie, additional, Shields, Robert W., additional, Siddique, Nailah, additional, Siddique, Teepu, additional, Siegal, Todd L., additional, Silberstein, Stephen D., additional, Stebbins, Glenn T., additional, Stevens, Suzanne, additional, Stickles, Scott, additional, Sufit, Robert, additional, Swanberg, Lt. Col. Margaret M., additional, Timmann, Dagmar, additional, Topel, Jordan L., additional, Tsai, Fong Y., additional, Vaidya, Chandan J., additional, Verdugo, Renato J., additional, Watson, Robert T., additional, Wilberger, Jack E., additional, Wilbourn, Asa J., additional, Wyllie, Elaine, additional, Young, William B., additional, and Yung, W. K. Alfred, additional

Published
2007
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283. Oxaluric acid as the major product of singlet oxygen-mediated oxidation of 8-oxo-7,8-dihydroguanine in DNA

Author

Duarte, Victor, Gasparutto, Didier, Yamaguchi, Lydia F., Ravanat, Jean-Luc, Martinez, Glaucia R., Medeiros, Marisa H.G., Di Mascio, Paolo, and Cadet, Jean

Subjects
DNA -- Research, Oxidation-reduction reaction -- Research, Chemistry
Abstract

Oxidative degradation of DNA is examined in the context of oxaluric acid, a major product of singlet oxygen-mediated oxidation.

Published
2000

285. Solution structure by NMR and molecular dynamics of a duplex containing a guanine opposite a N-(2-deoxy-beta-D-erythro-pentofuranosyl)formamide lesion

Author

Maufrais, Corinne, Fazakerley, G. Victor, Cadet, Jean, and Boulard, Yves

Subjects
Biochemistry -- Research, Nuclear magnetic resonance spectroscopy -- Usage, Molecular dynamics -- Analysis, Guanine -- Research, Biological sciences, Chemistry
Abstract

Research has been conducted on the ring fragmentation thymine product N-(2-deoxy-beta-D-erythro-pentofuranosyl)formamide residue. The use of the one- and two-dimensional NMR spectroscopy is described.

Published
2000

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