262 results on '"C A, Maggi"'
Search Results
252. The effect of the isotope on the H-mode density limit
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A. Huber, G. Sips, E. Joffrin, G. F. Matthews, F. Reimold, M. Wischmeier, S. Wiesen, T. Eich, A. G. Meigs, C. F. Maggi, Ch. Linsmeier, C.G. Lowry, Gennady Sergienko, Ph. Mertens, E. Delabie, P. Abreu, E. Viezzer, V. Huber, A. Kallenbach, Peter Lang, M.F. Stamp, A. Boboc, M. Brix, A. V. Chankin, Jet Contributors, C. Guillemaut, U. Kruezi, S. Jachmich, H. Zohm, J. Schweinzer, D. Carralero, S. Brezinsek, H. G. Esser, M. Bernert, JET Contributors, and ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society
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Nuclear and High Energy Physics ,Materials science ,Isotope ,Mode (statistics) ,Plasma ,Condensed Matter Physics ,01 natural sciences ,010305 fluids & plasmas ,Metal ,Deuterium ,Physics::Plasma Physics ,visual_art ,0103 physical sciences ,visual_art.visual_art_medium ,Density limit ,Atomic physics ,010306 general physics - Abstract
In order to understand the mechanisms for the H-mode density limit in machines with fully metallic walls, systematic investigations of H-mode density limit plasmas in experiments with deuterium and ...
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253. The second phase of JET operation with the ITER-like wall
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Isabel L. Nunes, I. T. Chapman, G. Sips, P. de Vries, C. F. Maggi, S. Brezinsek, G. F. Matthews, J. Hobirk, Efda-Jet Contributors, L. D. Horton, F.G. Rimini, and EFDA-JET Contributors
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Jet (fluid) ,Plasma parameters ,Divertor ,Nuclear engineering ,chemistry.chemical_element ,Plasma ,Edge (geometry) ,Tungsten ,Condensed Matter Physics ,01 natural sciences ,7. Clean energy ,Instability ,Atomic and Molecular Physics, and Optics ,010305 fluids & plasmas ,Material selection ,chemistry ,0103 physical sciences ,Environmental science ,010306 general physics ,Mathematical Physics - Abstract
The first priority for the 2013 JET campaigns will be to provide relevant data for the ITER decision on the day one divertor material selection. In particular, a tungsten melt experiment using a specially modified divertor module will study the characteristics and impact of edge localised mode (ELM) induced melting on plasma operation—only JET has large enough ELMs to perform such a test. The second priority is to better understand why the change to an all metal wall has restricted access to scenarios with high normalized energy confinement ( H -factor). This unexpected result may be partly due to the impact of the higher fuelling needed to control tungsten levels but in some scenarios there is also an effect related to the loss of a beneficial effect of carbon as a plasma impurity. In parallel with pushing JET's core plasma parameters as close as possible to those in ITER, we also intend to develop ITER demonstration pulses including as many of ITER's requirements as possible but not focusing on core performance. Another high priority item is the study of the generation and mitigation of runaway electrons which are so far not created in JET disruptions but are potentially very challenging for JET and ITER. Finally, there is still important work to be continued on key plasma–wall interaction issues ranging from material migration to fuel removal studies.
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254. The near infrared imaging system for the real-time protection of the JET ITER-like wall
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I. Balboa, P. J. Lomas, S. Collins, Ch. Linsmeier, G. Arnoux, Jet Contributors, P. McCullen, P. Puglia, A. G. Meigs, C. Balorin, Pedro Carvalho, K.-D. Zastrow, P. Carman, N. J. Conway, G. F. Matthews, A. Huber, S. Jachmich, C.G. Lowry, V. Riccardo, C. F. Maggi, V. Huber, F.G. Rimini, M. Price, M. Tsalas, Ph. Mertens, D. Kinna, Isabel L. Nunes, B. Lomanowski, T. May-Smith, Gennady Sergienko, and M. Jouve
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Jet (fluid) ,Materials science ,business.industry ,Astrophysics::High Energy Astrophysical Phenomena ,Near-infrared spectroscopy ,Imaging diagnostic ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Plasma ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,010305 fluids & plasmas ,Optics ,0103 physical sciences ,High Energy Physics::Experiment ,Near infrared imaging ,010306 general physics ,business ,Astrophysics::Galaxy Astrophysics ,Mathematical Physics - Abstract
This paper describes the design, implementation and operation of the near infrared (NIR) imaging diagnostic system of the JET ITER-like wall (JET-ILW) plasma experiment and its integration into the ...
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255. The near infrared imaging system for the real-time protection of the JET ITER-like wall.
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A Huber, D Kinna, V Huber, G Arnoux, I Balboa, C Balorin, P Carman, P Carvalho, S Collins, N Conway, P McCullen, S Jachmich, M Jouve, Ch Linsmeier, B Lomanowski, P J Lomas, C G Lowry, C F Maggi, G F Matthews, and T May-Smith
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- 2017
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256. EDGE2D-EIRENE modelling of near SOL E r: possible impact on the H-mode power threshold.
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A V Chankin, E Delabie, G Corrigan, D Harting, C F Maggi, H Meyer, and Contributors, JET
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DIVERTERS (Electronics) ,H-mode plasma confinement ,ELECTRIC fields ,PLASMA density ,SIMULATION methods & models - Abstract
Recent EDGE2D-EIRENE simulations of JET plasmas showed a significant difference between radial electric field (E
r ) profiles across the separatrix in two divertor configurations, with the outer strike point on the horizontal target (HT) and vertical target (VT) (Chankin et al 2016 Nucl. Mater. Energy, doi: 10.1016/j.nme.2016.10.004). Under conditions (input power, plasma density) where the HT plasma went into the H-mode, a large positive Er spike in the near scrape-off layer (SOL) was seen in the code output, leading to a very large E × B shear across the separatrix over a narrow region of a fraction of a cm width. No such Er feature was obtained in the code solution for the VT configuration, where the H-mode power threshold was found to be twice as high as in the HT configuration. It was hypothesised that the large E × B shear across the separatrix in the HT configuration could be responsible for the turbulence suppression leading to an earlier (at lower input power) L–H transition compared to the VT configuration. In the present work these ideas are extended to cover some other experimental observations on the H-mode power threshold variation with parameters which typically are not included in the multi-machine H-mode power threshold scalings, namely: ion mass dependence (isotope H–D–T exchange), dependence on the ion ∇B drift direction, and dependence on the wall material composition (ITER-like wall versus carbon wall in JET). In all these cases EDGE2D-EIRENE modelling shows larger positive Er spikes in the near SOL under conditions where the H-mode power threshold is lower, at least in the HT configuration. [ABSTRACT FROM AUTHOR]- Published
- 2017
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257. Impact of divertor geometry on radiative divertor performance in JET H-mode plasmas.
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A E Jaervinen, S Brezinsek, C Giroud, M Groth, C Guillemaut, P Belo, M Brix, G Corrigan, P Drewelow, D Harting, A Huber, K D Lawson, B Lipschultz, C F Maggi, G F Matthews, A G Meigs, D Moulton, M F Stamp, S Wiesen, and Contributors, JET
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FUSION reactor divertors ,GEOMETRY ,PLASMA density ,SIMULATION methods & models ,HEAT flux - Abstract
Radiative divertor operation in JET high confinement mode plasmas with the ITER-like wall has been experimentally investigated and simulated with EDGE2D-EIRENE in horizontal and vertical low field side (LFS) divertor configurations. The simulations show that the LFS divertor heat fluxes are reduced with N2-injection in similar fashion in both configurations, qualitatively consistent with experimental observations. The simulations show no substantial difference between the two configurations in the reduction of the peak LFS heat flux as a function of divertor radiation, nitrogen concentration, or pedestal Zeff. Consistently, experiments show similar divertor radiation and nitrogen injection levels for similar LFS peak heat flux reduction in both configurations. Nevertheless, the LFS strike point is predicted to detach at 20% lower separatrix density in the vertical than in the horizontal configuration. However, since the peak LFS heat flux in partial detachment in the vertical configurations is shifted towards the far scrape-off layer (SOL), the simulations predict no benefit in the reduction of LFS peak heat flux for a given upstream density in the vertical configuration relative to a horizontal one. A factor of 2 reduction of deuterium ionization source inside the separatrix is observed in the simulations when changing to the vertical configuration. The simulations capture the experimentally observed particle and heat flux reduction at the LFS divertor plate in both configurations, when adjusting the impurity injection rate to reproduce the measured divertor radiation. However, the divertor D
α -emissions are underestimated by a factor of 2–5, indicating a short-fall in radiation by the fuel species. In the vertical configuration, detachment is experimentally measured and predicted to start next to the strike point, extending towards the far SOL with increasing degree of detachment. In contrast, in the horizontal configuration, the entire divertor particle flux profile is reduced uniformly with increasing degree of detachment. [ABSTRACT FROM AUTHOR]- Published
- 2016
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258. Determination of tungsten and molybdenum concentrations from an x-ray range spectrum in JET with the ITER-like wall configuration.
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T Nakano, A E Shumack, C F Maggi, M Reinke, K D Lawson, I Coffey, T Pütterich, S Brezinsek, B Lipschultz, G F Matthews, M Chernyshova, K Jakubowska, M Scholz, J Rzadkiewicz, T Czarski, W Dominik, G Kasprowicz, K Pozniak, W Zabolotny, and K-D Zastrow
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TUNGSTEN ,MOLYBDENUM ,X-rays ,X-ray spectrometers ,MAGNETIC fields ,REFLECTANCE spectroscopy - Abstract
The and 3p–4d inner shell excitation lines in addition to 2p–3s lines have been identified from the spectrum taken by an upgraded high-resolution x-ray spectrometer. It is found from analysis of the absolute intensities of the and lines that W and Mo concentrations are in the range of and , respectively, with a ratio of ∼5% in JET with the ITER-like wall configuration for ELMy H-mode plasmas with a plasma current of 2.0–2.5 MA, a toroidal magnetic field of 2.7 T and a neutral beam injection power of 14–18 MW. For the purpose of checking self-consistency, it is confirmed that the W concentration determined from the line is in agreement with that from the line within 20% and that the plasma effective charge determined from the continuum of the first order reflection spectrum is also in agreement with that from the second order within 50%. Further, the determined plasma effective charge is in agreement with that determined from a visible spectroscopy, confirming that the sensitivity of the x-ray spectrometer is valid and that the W and the Mo concentrations are also likely to be valid. [ABSTRACT FROM AUTHOR]
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- 2015
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259. ELM control at the L → H transition by means of pellet pacing in the ASDEX Upgrade and JET all-metal-wall tokamaks.
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P T Lang, H Meyer, G Birkenmeier, A Burckhart, I S Carvalho, E Delabie, L Frassinetti, G Huijsmans, G Kocsis, A Loarte, C F Maggi, M Maraschek, B Ploeckl, F Rimini, F Ryter, S Saarelma, T Szepesi, E Wolfrum, and Contributors, ASDEX Upgrade Team and J. E. T.
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TOKAMAKS ,PLASMA confinement ,MAGNETOHYDRODYNAMICS ,PLASMA waves - Abstract
In ITER, pellets are used for ELM pacing and fueling. More importantly, ELM control and in particular control of the first ELM needs to be demonstrated in the non-nuclear phase of ITER during operation in H or He. Whilst D pellets have been established as an ELM control technique in the stationary phase with D target plasmas in devices with C as plasma-facing component, the behavior of other isotopes in non-stationary phases are not so well known. Here, we report on new pellet triggering experiments in ASDEX Upgrade and JET that mimic specific ITER operating scenarios. Both machines are equipped with an all-metal wall; recent investigations have shown that pellet triggering and pacing become more intricate when an all-metal wall surface is employed. In both machines, ELM triggering has been shown to occur after injection of D pellets into D plasmas during extended ELM-free phases, often following the L → H transition. In both devices the pellets are found to induce ELMs under conditions far from the stability boundary for type-I ELMs. Near the L → H transition, induced ELMs in some cases are more likely to have type-III rather than type-I characteristics. Furthermore, in ASDEX Upgrade this study was conducted during L → H transitions in the current ramp-up phase as envisaged for ITER. In addition, the pellet’s ELM trigger potential has been proven in ASDEX Upgrade with a correct isotopic compilation for the non-nuclear phase in ITER, viz. H pellets into either He or H plasmas.Results from this study are encouraging since they have demonstrated the pellets’ potential to provoke ELMs even under conditions that are quite far from the stability boundaries attributed to the occurrence of spontaneous ELMs. However, with the recent change from carbon to an all-metal plasma-facing component, examples have been found in both machines where pellets failed to establish ELM control under conditions where this would be expected and needed. Consequently, a major task of future investigations in this field will be to shed more light on the underlying physics of the pellet ELM triggering process to allow sound predictions for ITER. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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260. Theoretical description of heavy impurity transport and its application to the modelling of tungsten in JET and ASDEX upgrade.
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F J Casson, L Garzotti, C Giroud, C Angioni, R Bilato, T Odstrcil, T Pütterich, J Hobirk, C F Maggi, E A Belli, P Mantica, M Valisa, J Mlynar, and M L Reinke
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TUNGSTEN ,PLASMA flow ,ELECTROSTATIC fields ,TOMOGRAPHY ,SOFT X rays - Abstract
The effects of poloidal asymmetries and heated minority species are shown to be necessary to accurately describe heavy impurity transport in present experiments in JET and ASDEX Upgrade. Plasma rotation, or any small background electrostatic field in the plasma, such as that generated by anisotropic external heating can generate strong poloidal density variation of heavy impurities. These asymmetries have recently been added to numerical tools describing both neoclassical and turbulent transport and can increase neoclassical tungsten transport by an order of magnitude. Modelling predictions of the steady-state two-dimensional tungsten impurity distribution are compared with tomography from soft x-ray diagnostics. The modelling identifies neoclassical transport enhanced by poloidal asymmetries as the dominant mechanism responsible for tungsten accumulation in the central core of the plasma. Depending on the bulk plasma profiles, turbulent diffusion and neoclassical temperature screening can prevent accumulation. Externally heated minority species can significantly enhance temperature screening in ICRH plasmas. [ABSTRACT FROM AUTHOR]
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- 2015
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261. A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627
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Carlo Alberto Maggi, Vincenzo Pavone, A.R. Renzetti, Laura Quartara, Angelina Lombardi, Carlo Pedone, L., Quartara, Pavone, Vincenzo, C., Pedone, Lombardi, Angelina, A. R., Renzetti, and C. A., Maggi
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Agonist ,Male ,Physiology ,medicine.drug_class ,Stereochemistry ,Clinical Biochemistry ,Hamster ,Peptide ,Biochemistry ,Peptides, Cyclic ,Cellular and Molecular Neuroscience ,Endocrinology ,In vivo ,Cricetinae ,medicine ,Animals ,Humans ,chemistry.chemical_classification ,Bicyclic molecule ,Chemistry ,Antagonist ,Biological activity ,Receptors, Neurokinin-2 ,Rats ,Competitive antagonist ,Drug Design ,Rabbits - Abstract
We review the reported data on the design, the conformational features and the pharmacological properties of the bicyclic peptide tachykinin NK2 receptor antagonist MEN 10,627 or cyclo(Met-Asp-Trp-Phe-Dap-Leu)cyclo(2 beta-5 beta). MEN 10,627 possesses a highly constrained structure characterized by two consecutive beta-turns, as confirmed by the almost coincident results of NMR and X-ray analyses. The compound has been efficiently synthesized by solid-phase methodology using either Boc or Fmoc strategies. It is quite stable to metabolic degradation and is endowed with high affinity and selectivity for NK2 receptor expressed in various species. At the hamster NK2 receptor MEN 10,627 is about 30-fold more potent than the nonpeptide NK2 receptor antagonist, SR 48,968, while the converse is true for the rabbit NK2 receptor. MEN 10,627 and SR 48,968 show comparable affinities for the human NK2 receptor. MEN 10,627 produces a long lasting inhibition of the response to the selective NK2 receptor agonist [beta Ala8]NKA(4-10) in the rat urinary bladder in vivo after intravenous, intranasal and intraduodenal administration. Therefore different administration routes are possible for this compound that overcomes the usual drawbacks for the application of peptides as drugs.
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- 1996
262. Conformational Rigidity Versus Flexibility in a Novel Peptidic Neurokinin A Receptor Antagonist
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Vincenzo Pavone, Laura Quartara, Carlo Alberto Maggi, Carlo Pedone, Angelina Lombardi, Pavone, Vincenzo, Lombardi, Angelina, L., Quartara, C. A., Maggi, and C., Pedone
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Male ,medicine.drug_class ,Protein Conformation ,Guinea Pigs ,Urinary Bladder ,Pharmacology ,In Vitro Techniques ,Biochemistry ,Peptides, Cyclic ,chemistry.chemical_compound ,Structure-Activity Relationship ,Protein structure ,Structural Biology ,Cricetinae ,Drug Discovery ,medicine ,Structure–activity relationship ,Animals ,Amino Acid Sequence ,Receptor ,Molecular Biology ,chemistry.chemical_classification ,Molecular Structure ,Organic Chemistry ,Rational design ,Biological activity ,Muscle, Smooth ,General Medicine ,Receptors, Neurokinin-2 ,Receptor antagonist ,Cyclic peptide ,Rats ,chemistry ,Drug Design ,Molecular Medicine ,Neurokinin A ,Rabbits - Abstract
Neurokinin A receptor antagonists have been proposed as a new class of drugs for several applications in humans (asthama, intestinal motility, etc.). The rational design, synthesis, structural characterization and biological activity evaluation of a new potent, highly selective, long-lasting, peptide-based receptor antagonist are reported. The structure–activity relationship indicates that the conformational rigidity determines potency, specificity and especially the long life of the molecule in the living body. MEN 10627 is the prototype of a new class of cyclic, peptide-based, neurokinin A receptor antagonists and it is a suitable candidate for clinical testing in humans.
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- 1995
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