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251. Fixed points of (0,2) Landau-Ginzburg renormalization group flows and the chiral algebra

Author: Bertolini, Marco, Melnikov, Ilarion V., and Plesser, M. Ronen
Subjects: High Energy Physics - Theory
Abstract: We discuss renormalization group flows in two-dimensional quantum field theories with (0,2) supersymmetry. We focus on theories with UV described by a Landau-Ginzburg Lagrangian and use the chiral algebra to constrain the IR dynamics. We present examples where the structure of the chiral algebra is incompatible with unitarity of the IR superconformal theory and discuss the implications of this result for programs of classifying (0,2) SCFTs as endpoints of flows from simple Lagrangian theories., Comment: 44 pages; v2: minor changes to discussion, fixed typos
Published: 2021
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252. Constraints on dark photon dark matter using data from LIGO's and Virgo's third observing run

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adhikari, N., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Allocca, A., Altin, P. A., Amato, A., Anand, C., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrić, T., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koji, Arai, Koya, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Assiduo, M., Aston, S. M., Astone, P., Aubin, F., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Badger, C., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhardwaj, U., Bhattacharjee, D., Bhaumik, S., Bilenko, I. A., Billingsley, G., Bini, S., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bonavena, L. D., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Cameron, J., Camp, J. B., Canepa, M., Canevarolo, S., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carrillo, G., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Ceasar, M., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y-K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, S., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Davis, M. C., Daw, E. J., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Freed, J. P., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Gould, D. W., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerra, D., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heidt, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Hernandez, A. G., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jeunon, M., Jia, W., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, P., Jung, k., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kuijer, P., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kuwahara, S., Kwak, K., Lagabbe, P., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leonardi, M., Leroy, N., Letendre, N., Levesque, C., Levin, Y., Leviton, J. N., Leyde, K., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llamas, F., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Lousto, C. O., Lovelace, G., Lucaccioni, J. F., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Lynam, J. E., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, S., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., McCann, J. J., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGuire, S. C., McIsaac, C., McIver, J., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Miller, A., Miller, B., Millhouse, M., Mills, J. C., Milotti, E., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Moguel, E., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Muusse, S., Nadji, S. L., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Napolano, V., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neubauer, P., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nitoglia, E., Nocera, F., Norman, M., North, C., Nozaki, S., Nuttall, L. K., Oberling, J., O'Brien, B. D., Obuchi, Y., O'Dell, J., Oelker, E., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Oram, R., O'Reilly, B., Ormiston, R. G., Ormsby, N. D., Ortega, L. F., O'Shaughnessy, R., O'Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Otabe, S., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Pan, K., Panda, P. K., Pang, H., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Panther, F. H., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, H., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patricelli, B., Patron, A. S., Patrone, S., Paul, S., Payne, E., Pedraza, M., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C. J., Périgois, C., Perkins, C. C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pinto, I. M., Pinto, M., Piotrzkowski, K., Pirello, M., Pitkin, M. D., Placidi, E., Planas, L., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Poulton, R., Powell, J., Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rapagnani, P., Rapol, U. D., Ray, A., Raymond, V., Raza, N., Razzano, M., Read, J., Rees, L. A., Regimbau, T., Rei, L., Reid, S., Reid, S. W., Reitze, D. H., Relton, P., Renzini, A., Rettegno, P., Rezac, M., Ricci, F., Richards, D., Richardson, J. W., Richardson, L., Riemenschneider, G., Riles, K., Rinaldi, S., Rink, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J. G., Romanelli, M., Romano, R., Romel, C. L., Romero-Rodríguez, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Rosa, L., Rose, C. A., Rosińska, D., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, S., Roy, Santosh, Roy, Soumen, Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O. S., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sanchez, E. J., Sanchez, J. 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Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We present a search for dark photon dark matter that could couple to gravitational-wave interferometers using data from Advanced LIGO and Virgo's third observing run. To perform this analysis, we use two methods, one based on cross-correlation of the strain channels in the two nearly aligned LIGO detectors, and one that looks for excess power in the strain channels of the LIGO and Virgo detectors. The excess power method optimizes the Fourier Transform coherence time as a function of frequency, to account for the expected signal width due to Doppler modulations. We do not find any evidence of dark photon dark matter with a mass between $m_{\rm A} \sim 10^{-14}-10^{-11}$ eV/$c^2$, which corresponds to frequencies between 10-2000 Hz, and therefore provide upper limits on the square of the minimum coupling of dark photons to baryons, i.e. $U(1)_{\rm B}$ dark matter. For the cross-correlation method, the best median constraint on the squared coupling is $\sim2.65\times10^{-46}$ at $m_{\rm A}\sim4.31\times10^{-13}$ eV/$c^2$; for the other analysis, the best constraint is $\sim 2.4\times 10^{-47}$ at $m_{\rm A}\sim 5.7\times 10^{-13}$ eV/$c^2$. These limits improve upon those obtained in direct dark matter detection experiments by a factor of $\sim100$ for $m_{\rm A}\sim [2-4]\times 10^{-13}$ eV/$c^2$, and are, in absolute terms, the most stringent constraint so far in a large mass range $m_A\sim$ $2\times 10^{-13}-8\times 10^{-12}$ eV/$c^2$., Comment: 20 pages, 7 figures; In the latest version, we integrated the changes reported in the published erratum (DOI: https://doi.org/10.1103/PhysRevD.109.089902). Essentially, we overestimated the sensitivity of the cross-correlation search to a dark photon dark matter signal and have corrected this, making the BSD limits the most stringent in this search at most dark photon masses
Published: 2021
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253. Searches for continuous gravitational waves from young supernova remnants in the early third observing run of Advanced LIGO and Virgo

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. 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Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present results of three wide-band directed searches for continuous gravitational waves from 15 young supernova remnants in the first half of the third Advanced LIGO and Virgo observing run. We use three search pipelines with distinct signal models and methods of identifying noise artifacts. Without ephemerides of these sources, the searches are conducted over a frequency band spanning from 10~Hz to 2~kHz. We find no evidence of continuous gravitational radiation from these sources. We set upper limits on the intrinsic signal strain at 95\% confidence level in sample sub-bands, estimate the sensitivity in the full band, and derive the corresponding constraints on the fiducial neutron star ellipticity and $r$-mode amplitude. The best 95\% confidence constraints placed on the signal strain are $7.7\times 10^{-26}$ and $7.8\times 10^{-26}$ near 200~Hz for the supernova remnants G39.2--0.3 and G65.7+1.2, respectively. The most stringent constraints on the ellipticity and $r$-mode amplitude reach $\lesssim 10^{-7}$ and $ \lesssim 10^{-5}$, respectively, at frequencies above $\sim 400$~Hz for the closest supernova remnant G266.2--1.2/Vela Jr., Comment: https://dcc.ligo.org/P2000479
Published: 2021
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254. Search for lensing signatures in the gravitational-wave observations from the first half of LIGO-Virgo's third observing run

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Asali, Y., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Bagnasco, S., Bai, Y., Baird, J., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Byer, R. L., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Cain III, H. W., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, J., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. 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M., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Easter, P. J., Ebersold, M., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Ezquiaga, J. M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. 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W., Hartwig, D., Haskell, B., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Hines, A. S., Hochheim, S., Hofman, D., Hohmann, J. N., Holgado, A. M., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hopkins, P., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsu, Y., Huang, Y., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Inchauspe, H., Ingram, C., Intini, G., Isi, M., Isleif, K., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. 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Y., Watchi, J., Weaver, B., Wei, L., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilken, D., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Winkler, W., Wipf, C. C., Wlodarczyk, T., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wright, M., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, F. W., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Yeung, M. C., Ying, M., Yoon, A., Yu, Hang, Yu, Haocun, Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhao, C., Zhao, G., Zhao, Y., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zucker, M. E., and Zweizig, J.
Subjects: General Relativity and Quantum Cosmology, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We search for signatures of gravitational lensing in the gravitational-wave signals from compact binary coalescences detected by Advanced LIGO and Advanced Virgo during O3a, the first half of their third observing run. We study: 1) the expected rate of lensing at current detector sensitivity and the implications of a non-observation of strong lensing or a stochastic gravitational-wave background on the merger-rate density at high redshift; 2) how the interpretation of individual high-mass events would change if they were found to be lensed; 3) the possibility of multiple images due to strong lensing by galaxies or galaxy clusters; and 4) possible wave-optics effects due to point-mass microlenses. Several pairs of signals in the multiple-image analysis show similar parameters and, in this sense, are nominally consistent with the strong lensing hypothesis. However, taking into account population priors, selection effects, and the prior odds against lensing, these events do not provide sufficient evidence for lensing. Overall, we find no compelling evidence for lensing in the observed gravitational-wave signals from any of these analyses., Comment: 31 pages and 6 figures. Accepted by the Astrophysical Journal
Published: 2021
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255. Os fatores que envolvem o desenvolvimento de produtos ecoinovadores em incubadoras de empresas brasileiras/The factors that involve the development of eco-innovative products at brazilian business incubators

Author: Pellin, Alecxandro, Trento, FranÃ§ois Fabiane, Neto, Pedro Lachovicz, Bertolini, Geysler Rogis Flor, and Johann, Jerry Adriani
Published: 2023
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256. Virulence Potential, Biofilm Formation, and Disinfectants Control of Escherichia coli from Raw Milk Bulk Tanks in the Southeast of Brazil

Author: Sâmea Joaquim Aguiar Soares, Felipe de Freitas Guimarães, Gabriel Augusto Marques Rossi, Simony Trevizan Guerra, Felipe Morales Dalanezi, Bruna Churocof Lopes, Mateus de Souza Ribeiro Mioni, Ana Carolina Yamakawa, Evelyn Cristine da Silva, Gustavo Nunes de Moraes, Amanda Bezerra Bertolini, Márcio Garcia Ribeiro, José Carlos de Figueiredo Pantoja, Simone Baldini Lucheis, Vera Lucia Mores Rall, Rodrigo Tavanelli Hernandes, Domingos da Silva Leite, and Helio Langoni
Subjects: dairy, disinfectants, enterobacteria, ExPEC, milk, pathogen, Dairy processing. Dairy products, SF250.5-275
Abstract: Escherichia coli is a major player in foodborne illnesses, capable of forming biofilms on dairy facilities, leading to milk contamination. Thus, we examined the capacity of E. coli strains from raw milk bulk tanks to form biofilms on surfaces made of polystyrene, stainless steel, and silicone; the potential links between biofilm formation with genes responsible for fimbriae and virulence factors of extra-intestinal E. coli (ExPEC); and the susceptibility of biofilm-forming isolates to iodine and chlorhexidine digluconate. Out of 149 E. coli strains, 42.28% (63/149) formed biofilm on polystyrene, 56.38% (84/149) on silicone, and 21.48% (32/149) on stainless steel. The frequency of genes was: fimH (100%), hlyA (5.4%), irp2 (2.7%), sitA (10.7%), ompT (43.6%), and traT (98%). No biofilm developed when disinfectants were used prior to biofilm formation. However, iodine and chlorhexidine digluconate allowed 25.40% (16/63) of isolates displaying growth after a mature biofilm was formed. The presence of biofilm on different surfaces emphasizes the vital need for thorough equipment cleaning, both in farms and in industrial dairy settings. Rapid disinfection is crucial, given the reduced susceptibility of potentially pathogenic E. coli after biofilm maturity.
Published: 2023
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257. Influência do Comprimento de Corpos-de-Prova na Obtenção do Módulo de Elasticidade Ec0

Author: Marília da Silva Bertolini, Diogo Aparecido Lopes Silva, Amós Magalhães de Souza, Carlito Calil Neto, and Francisco Antonio Rocco Lahr
Subjects: madeira, compressão paralela às fibras, módulo de elasticidade, comprimento de corpos-de-prova., Forestry, SD1-669.5
Abstract: RESUMO As dimensões de corpos-de-prova para caracterização da madeira são estabelecidas sempre buscando situações em que seja anulada a interferência do atrito nas medidas de deformação. A NBR 7190 (ABNT, 1997) - Anexo B adota corpos-de-prova para o ensaio de compressão paralela às fibras com relação 1:3 entre uma aresta da seção transversal (50 mm) e o comprimento, enquanto a COPANT 464 (COPANT, 1972) e ASTM D 143 (ASTM, 1982) estabelecem a de 1:4. Este trabalho objetivou determinar se as proporções 1:3, 1:4 e 1:5 nos corpos-de-prova, referentes aos comprimentos de 150, 200 e 250 mm, respectivamente, influenciam o Ec0 obtido na compressão paralela às fibras. As análises foram realizadas nas espécies Canelão (Nectandra membranacea), Corymbia citriodora e Angelim (Vatairea sp.). Os valores de Ec0 para as espécies citadas apresentaram-se estatisticamente equivalentes entre si, ao nível de 5% de significância, demonstrando que as variações nos comprimentos dos corpos-de-prova não afetaram esta propriedade.
Published: 2023
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258. Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling

Author: Ilaria Petraroia, Patrizia Ghidotti, Giulia Bertolini, Francesca Pontis, Luca Roz, Melissa Balsamo, Paola Suatoni, Ugo Pastorino, Anna Maria Ferretti, Gabriella Sozzi, and Orazio Fortunato
Subjects: Cytology, QH573-671
Abstract: Abstract Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their extracellular vesicles (EVs). We aimed to evaluate the potential role of circulating EVs from COPD subjects in lung cancer onset. Plasma-EVs were isolated by ultracentrifugation from heavy smoker volunteers with (COPD-EVs) or without (heavy smoker-EVs, HS-EV) COPD and characterized following MISEV guidelines. Immortalized human bronchial epithelial cells (CDK4, hTERT-HBEC3-KT), genetically modified with different oncogenic alterations commonly found in lung cancer (sh-p53, KRASV12), were used to test plasma-EVs pro-tumorigenic activity in vitro. COPD-EVs mainly derived from immune and endothelial cells. COPD-EVs selectively increased the subset of CD133+CXCR4+ metastasis initiating cells (MICs) in HBEC-sh-p53-KRASV12high cells and stimulated 3D growth, migration/invasion, and acquisition of mesenchymal traits. These effects were not observed in HBEC cells bearing single oncogenic mutation (sh-p53 or KRASV12). Mechanistically, hypoxia-inducible factor 1-alpha (HIF-1α) transferred from COPD-EVs triggers CXCR4 pathway activation that in turn mediates MICs expansion and acquisition of pro-tumorigenic effects. Indeed, HIF-1α inhibition or CXCR4 silencing prevented the acquisition of malignant traits induced by COPD-EVs alone. Hypoxia recapitulates the effects observed with COPD-EVs in HBEC-sh-p53-KRASV12high cells. Notably, higher levels of HIF-1α were observed in EVs from COPD subjects who subsequently developed cancer compared to those who remained cancer-free. Our findings support a role of COPD-EVs to promote the expansion of MICs in premalignant epithelial cells through HIF-1α-CXCR4 axis activation thereby potentially sustaining lung cancer progression.
Published: 2023
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259. May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?

Author: Ciro Mazzarella, Silvia Chiesa, Lucrezia Toppi, Stefan Hohaus, Simona Gaudino, Francesco D’Alo, Nicola Dinapoli, Resta Davide, Tiziano Zinicola, Serena Bracci, Antonella Martino, Francesco Beghella Bartoli, Elisabetta Lepre, Roberta Bertolini, Silvia Mariani, Cesare Colosimo, Vincenzo Frascino, Gian Carlo Mattiucci, Maria Antonietta Gambacorta, Vincenzo Valentini, and Mario Balducci
Subjects: PCNSL, Hippocampal sparing, WBRT, IMRT, Neuro-toxicity, Personalized treatment, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Purpose One of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment of neurocognitive functions (NCFs), which is mainly caused by radiation-induced injury to the hippocampus. With a view to preventing NCF impairment and personalizing treatment, we explored the feasibility of sparing the hippocampus during WBRT by correlating the sites of PCNSL lesions with the hippocampus. Methods and materials Pre-treatment MR images from patients who underwent WBRT between 2010 and January 2020—and post-radiotherapy images in cases of relapse—were imported into the Varian Eclipse treatment-planning system and registered with the simulation CT. We constructed three 3-dimensional envelopes around the hippocampus at distances of 5, 10 and 15 mm and also contoured primary lesions and recurrences. Results We analyzed 43 patients with 66 primary lesions: 9/66 (13.6%) involved the hippocampus and 11/66 (16.7%) were located within 5 mm of it. Thirty-six lesions (54.5%) were situated more than 15 mm from the hippocampus, while 10/66 (15.2%) were between 5 and 15 mm from it. The most common location was in deep brain structures (31%). Thirty-five of the 66 lesions relapsed: in field in 14/35 (40%) and outfield in 21/35 (60%) in different sites. Globally, 16/35 recurrences (45.7%) were located in the hippocampus or within 5 mm of it. Conclusion These data show that routinely sparing the hippocampus is not feasible. This approach could be considered in selected patients, when the lesion is more than 15 mm from the hippocampus.
Published: 2023
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260. Development of poly(vinylidene fluoride)/thermoplastic polyurethane/carbon black‐polypyrrole composites with enhanced piezoelectric properties

Author: Mayara C. Bertolini, Nico Zamperlin, Guilherme M. O. Barra, and Alessandro Pegoretti
Subjects: fused filament fabrication, nanofiller, piezoelectric, polymer blend, PVDF, β phase, Polymers and polymer manufacture, TP1080-1185
Abstract: Abstract Poly(vinylidene fluoride)/thermoplastic polyurethane (PVDF/TPU) composites filled with carbon‐black polypyrrole were prepared via melt compounding followed by compression molding and fused filament fabrication. CB‐PPy was added to the blends from 0 up to 15% to possible act as nucleating filler for PVDF β phase in order to increase its piezoelectric response. The influence of blending PVDF and TPU and of the addition of CB‐PPy on the overall crystallinity, content of β phase, and piezoelectric response of composites were investigated by differential scanning calorimetry (DSC), Fourier‐transformed infrared spectroscopy (FTIR), X‐ray diffraction (XRD) and determination of the piezoelectric coefficient (d33). It was found that the addition of TPU to PVDF induced an increase of the crystallinity degree and content of β phase in PVDF. Moreover, although the degree of crystallinity of the composites decreased with the addition of CB‐PPy, the percentage of β phase in PVDF was increased. This effect is more significant in samples with filler concentration higher than 6 wt%. As expected, the d33 of the composites increased as the content of the β phase increased. Furthermore, 3D printed samples displayed lower content of β phase and reduced piezoelectric responses when compared to compression molded samples with same composition.
Published: 2023
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261. Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds

Author: Ahmed M. Sallam, Henry Reyer, Klaus Wimmers, Francesca Bertolini, Adel Aboul-Naga, Camila U. Braz, and Alaa Emara Rabee
Subjects: Adaptation, Local breeds, Selection signature, Inbreeding, Homozygosity, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract: Abstract Understanding the genomic features of livestock is essential for successful breeding programs and conservation. This information is scarce for local goat breeds in Egypt. In the current study, genomic regions with selection signatures were identified as well as runs of homozygosity (ROH), genomic inbreeding coefficients (FROH) and fixation index (FST) were detected in Egyptian Nubian, Damascus, Barki and Boer goat breeds. A total of 46,268 SNP markers and 337 animals were available for the genomic analyses. On average, 145.44, 42.02, 87.90 and 126.95 ROHs were detected per individual in the autosomal genome of the respective breeds. The mean accumulative ROH lengths ranged from 46.5 Mb in Damascus to 360 Mb in Egyptian Nubian. The short ROH segments ( 16 Mb) were exclusively found in the Egyptian Nubian. The highest average FROH was observed in Egyptian Nubian (~ 0.12) followed by Boer (~ 0.11), while the lowest FROH was found in Damascus (~ 0.05) and Barki breed (~ 0.03). The estimated mean FST was 0.14 (Egyptian Nubian and Boer), 0.077 (Egyptian Nubian and Barki), 0.075 (Egyptian Nubian and Damascus), 0.071 (Barki and Boer), 0.064 (Damascus and Boer), and 0.015 (Damascus and Barki), for each pair of breeds. Interestingly, multiple SNPs that accounted for high FST values were observed on chromosome 6 in regions harboring ALPK1 and KCNIP4. Genomic regions overlapping both FST and ROH harbor genes related to immunity (IL4R, PHF23, GABARAP, GPS2, and CD68), reproduction (SPATA2L, TNFSF12, TMEM95, and RNF17), embryonic development (TCF25 and SOX15) and adaptation (MC1R, KDR, and KIT), suggesting potential genetic adaptations to local environmental conditions. Our results contribute to the understanding of the genetic architecture of different goat breeds and may provide valuable information for effective preservation and breeding programs of local goat breeds in Egypt.
Published: 2023
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262. Patient’s safety and satisfaction on same day discharge after robotic and laparoscopic radical prostatectomy versus discharge after 24 or 48 h: a longitudinal randomized prospective study

Author: Eliney Ferreira Faria, Roberto Dias Machado, Rodrigo José Costa Gualberto, Marina Assunção Valadares Milani, Lucas Tadeu Bidinotto, Marcos Tobias Machado, Ricardo dos Reis, and Daniele Natália Pacharone Bertolini Bidinotto
Subjects: Early hospital discharge, Minimally invasive radical prostatectomy, Patient satisfaction, Prostatectomy, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Abstract Background There is a tendency of prompted global health systems to reduce the length of hospital stay without compromising patient safety or satisfaction. We evaluated the safety and viability of early discharge in patients undergoing minimally invasive radical prostatectomy (MIRP), as well as patient satisfaction with this strategy. Methods This longitudinal prospective study included 72 patients who underwent MIRP for prostate cancer. Three groups were performed according to the day of hospital discharge following surgery: same day (G1), first day after (G2), and second day after (G3). Satisfaction, adverse events, and readmission were analyzed for each group. Associations between clinicopathologic variables and same-day discharge were analyzed by comparing data between G1 patients who did and did not achieve same-day discharge. Results 16.7% of patients were not discharged according to randomization (10 randomized to G1). 80% of G1 patients who did not achieve same-day discharge had Gleason scores of 3 + 4 or 4 + 3, which were observed in 35.7% of patients discharged on the same day (P
Published: 2023
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263. Information systems in family agriculture: monitoring the use of software for financial management of properties

Author: Evandro Mendes de Aguiar, Sandra Mara Stocker Lago, Giani Carla Ito, and Geysler Rogis Flor Bertolini
Subjects: sustainable development, financialization of agriculture, agricultural modernization, land income, Agriculture (General), S1-972, Geography (General), G1-922
Abstract: This article aimed to analyze the monitoring of the use of financial management software by family farmers. Data on the use of the software were collected and tabulated from ten producers in the west and northwest region of Paraná, in addition to conducting a semi-structured interview with a field professional from a service cooperative. During the interview, it was identified that the producers' knowledge about finance is basic and superficial. However, even with limited knowledge, producers use the practice of a handwritten cash flow. Finally, it was concluded that the producers lack training and technical depth in the financial management of the property, uncomplicated tools, and that have their operation on mobile devices, however, they demonstrate conditions to use basic controls such as cash flow. It also revealed that producers are not available to acquire information technology resources because they do not have the financial resources to acquire them.
Published: 2023
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264. Implementation of evidence-based primary cancer prevention interventions in MA community health centers: an explanatory sequential mixed methods study

Author: Rebekka M. Lee, James G. Daly, Kamini Mallick, Shoba Ramanadhan, Cristina Huebner Torres, Cassidy R. Hayes, Alyssa Bertolini, Ra’Shaun Nalls, Karen M. Emmons, and the ISCCCE Partnership
Subjects: Nutrition, Physical activity, Tobacco, Federally qualified health centers, Community, Partnership, Medicine (General), R5-920
Abstract: Abstract Background More than half of cancers could be prevented by employing evidence-based interventions (EBIs), including prevention interventions targeting nutrition, physical activity, and tobacco. Federally qualified health centers (FQHCs) are the primary source of patient care for over 30 million Americans — making them an optimal setting for ensuring evidence-based prevention that advances health equity. The aims of this study are to (1) determine the degree to which primary cancer prevention EBIs are being implemented within Massachusetts FQHCs and (2) describe how these EBIs are implemented internally and via community partnerships. Methods We used an explanatory sequential mixed methods design to assess the implementation of cancer prevention EBIs. First, we collected 34 quantitative surveys from staff at 16 FQHCs across Massachusetts to determine the frequency of EBI implementation. We followed up with 12 qualitative one-on-one interviews among a sample of staff to understand how the EBIs selected on the survey were implemented. Exploration of contextual influences on implementation and use of partnerships was guided by the Consolidated Framework for Implementation Research (CFIR). Quantitative data were summarized descriptively, and qualitative analyses used reflexive, thematic approaches, beginning deductively with codes from CFIR, then inductively coding additional categories. Results All FQHCs indicated they offered clinic-based tobacco interventions, such as clinician-delivered screening practices and prescription of tobacco cessation medications. Quitline interventions and some diet/physical activity EBIs were available at all FQHCs, but staff perceptions of penetration were low. Only 38% of FQHCs offered group tobacco cessation counseling and 63% referred patients to mobile phone-based cessation interventions. We found multilevel factors influenced implementation across intervention types — including the complexity of intervention trainings, available time and staffing, motivation of clinicians, funding, and external policies and incentives. While partnerships were described as valuable, only one FQHC reported using clinical-community linkages for primary cancer prevention EBIs. Conclusions Adoption of primary prevention EBIs in Massachusetts FQHCs is relatively high, but stable staffing and funding are required to successfully reach all eligible patients. FQHC staff are enthusiastic about the potential of community partnerships to foster improved implementation—providing training and support to build these relationships will be key to fulfilling that promise.
Published: 2023
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265. Postoperative Pain Management in Coronary Artery Bypass Grafting: An Integrative Review

Author: Bertolini, Bruna, dos Santos Felix, Márcia M., de Andrade, Érica V., Raponi, Maria B.G., Calegari, Isadora B., Barichello, Elizabeth, da Silva Pires, Patrícia, and Barbosa, Maria H.
Published: 2024
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266. Physical and dosimetric characterisation of different Contrast-Enhanced digital mammographic systems: A multicentric study

Author: Ghetti, Caterina, Ortenzia, Ornella, Pagan, Laura, Golinelli, Paola, Nitrosi, Andrea, Sghedoni, Roberto, Ravaglia, Valentina, Verzellesi, Laura, Angelini, Lidia, Venturi, Giovanna, Berardi, Paola, Acchiappati, Domenico, and Bertolini, Marco
Published: 2024
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267. Pathological findings and patterns of feline infectious peritonitis in the respiratory tract of cats

Author: Slaviero, Mônica, Cony, Fernanda G., da Silva, Rodrygo C., De Lorenzo, Cíntia, de Almeida, Bruno A., Bertolini, Marianna, Driemeier, David, Pavarini, Saulo P., and Sonne, Luciana
Published: 2024
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268. Biomechanical repercussion of sitting posture on lumbar intervertebral discs: A systematic review

Author: Zanola, Renan Luiz, Donin, Cristiane Buzanello, Bertolini, Gladson Ricardo Flor, and Buzanello Azevedo, Márcia Rosângela
Published: 2024
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269. Analysis of the Frequency of Intraoperative Complications in Anterior Lumbar Interbody Fusion: A Systematic Review

Author: Dias Pereira Filho, Aécio Rubens, Baptista, Vinicius Santos, Valadares Bertolini Mussalem, Matheus Galvão, Frota Carneiro Júnior, Francisco Cialdine, de Meldau Benites, Vinicius, Desideri, Alexandre Vinhal, Uehara, Milton Kiyonory, Colaço Aguiar, Nuno Rodolfo, and Baston, Arthur Cristiano
Published: 2024
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270. Adjuvant Hypofractionated Whole Breast Irradiation (WBI) vs. Accelerated Partial Breast Irradiation (APBI) in Postmenopausal Women with Early Stage Breast Cancer: 5Years Update of the HYPAB Trial

Author: Lo Faro, L., Fogliata, A., Franceschini, D., Spoto, R., Dominici, L., Bertolini, A., Stefanini, S., Vernier, V., Ilieva, M.B., and Scorsetti, M.
Published: 2024
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271. Eddy current losses model and physical parameters evaluation for ferrite magnetic cores in frequency domain

Author: Bertolini, Vittorio, Stella, Marco, Scorretti, Riccardo, Faba, Antonio, and Cardelli, Ermanno
Published: 2024
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272. Biomimetic proteolipid vesicles for reverting GPI deficiency in paroxysmal nocturnal hemoglobinuria

Author: Giudice, Valentina, Scala, Pasqualina, Lamparelli, Erwin P., Gorrese, Marisa, Serio, Bianca, Bertolini, Angela, Picone, Francesca, Della Porta, Giovanna, and Selleri, Carmine
Published: 2024
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273. 3D printing of potassium sodium niobate by binder jetting: Printing parameters optimisation and correlation to final porosity

Author: Bertolini, Francesco, Mariani, Marco, Mercadelli, Elisa, Baldisserri, Carlo, Galassi, Carmen, Capiani, Claudio, Ardito, Raffaele, and Lecis, Nora
Published: 2024
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274. A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis

Author: Tietz, Julia, Gunde, Tea, Warmuth, Stefan, Weinert, Christopher, Brock, Matthias, Simonin, Alexandre, Hess, Christian, Johansson, Maria, Spiga, Fabio, Muntwiler, Simone, Wickihalder, Belinda, Mahler, Dana, Diem, Dania, Zeberer, Julia, Heiz, Robin, Flückiger, Naomi, Shiraishi, Noriko, Miyake, Yoshihide, Takahashi, Nobuaki, Fehrholz, Markus, Bertolini, Marta, Lichtlen, Peter, Urech, David, and Snell, Daniel
Published: 2024
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275. Dynamics and drivers of carbon sequestration and storage capacity in Phragmites australis-dominated wetlands

Author: Silan, Giulia, Buosi, Alessandro, Bertolini, Camilla, and Sfriso, Adriano
Published: 2024
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276. Typical values of z-resolution for different Digital Breast Tomosynthesis systems evaluated in a multicenter study

Author: Dalmonte, S., Golinelli, P., Oberhofer, N., Strocchi, S., Rossetti, V., Berta, L., Porzio, M., Angelini, L., Paruccini, N., Villa, R., Bertolini, M., Delle Canne, S., Cavallari, M., D'Ercole, L., Guerra, G., Rosasco, R., Cannillo, B., D'Alessio, A., Di Nicola, E., Origgi, D., De Marco, P., Maldera, A., Scabbio, C., Rottoli, F., Castriconi, R., Lorenzini, E., Pasquali, G., Pietrobon, F., Bregant, P., Giovannini, G., Favuzza, V., Bruschi, A., D'Urso, D., Maestri, D., De Novellis, S., Fracassi, A., Boschiroli, L., Quattrocchi, M., Gilio, M.A., Roberto, E., Altabella, L., Califano, G., Cimmino, M.C., Bortoli, E., Deiana, E., Pagan, L., Berardi, P., Ardu, V., Azzeroni, R., Campoleoni, M., and Ravaglia, V.
Published: 2024
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277. Comparing accuracy of tomosynthesis plus digital mammography or synthetic 2D mammography in breast cancer screening: baseline results of the MAITA RCT consortium

Author: Giorgi Rossi, Paolo, Mancuso, Pamela, Pattacini, Pierpaolo, Campari, Cinzia, Nitrosi, Andrea, Iotti, Valentina, Ponti, Antonio, Frigerio, Alfonso, Correale, Loredana, Riggi, Emilia, Giordano, Livia, Segnan, Nereo, Di Leo, Giovanni, Magni, Veronica, Sardanelli, Francesco, Fornasa, Francesca, Romanucci, Giovanna, Montemezzi, Stefania, Falini, Patrizia, Auzzi, Noemi, Zappa, Marco, Ottone, Marta, Mantellini, Paola, Duffy, Stephen W., Armaroli, Paola, Coriani, Chiara, Pescarolo, Manuela, Stefanelli, Gloria, Tondelli, Giulio, Beretti, Filippo, Caffarri, Sabrina, Marchesi, Vanessa, Canovi, Laura, Colli, Marco, Boschini, Mirco, Bertolini, Marco, Ragazzi, Moira, Ginocchi, Vladimiro, Ravaioli, Sara, Vacondio, Rita, Caroli, Stefania, Braglia, Luca, Cavuto, Silvio, Mancuso., Pamela, Djuric, Olivera, Venturelli, Francesco, Vicentini, Massimo, Braghiroli, Maria Barbara, Lonetti, Jasmine, Davoli, Elena, Bonelli, Efrem, Lucchi, Ilaria, Martello, Gessica, Rossati, Claudia, Ambrogetti, Daniela, Iossa, Anna, Carnesciali, Eva, Mazzalupo, Vincenzo, Puliti, Donella, Battisti, Francesca, Auzzi., Noemi, Verdi, Simona, Degl’Innocenti, Carolina, Tramalloni, Daniela, Cavazza, Elena, Busoni, Simone, Betti, Elisa, Peruzzi, Francesca, Regini, Francesco, Sardanelli., Francesco, Di Leo., Giovanni, Carbonaro, Luca Alessandro, Magni., Veronica, Cozzi, Andrea, Spinelli, Diana, Monaco, Cristian Giuseppe, Schiaffino, Simone, Benedek, Adrienn, Menicagli, Laura, Ferraris, Raffaella, Favettini, Elisabetta, Dettori, Davide, Falco, Paolo, Presti, Pietro, Segnan., Nereo, Armaroli., Paola, Marra, Vincenzo, Milanesio, Luisella, Artuso, Franca, Di Leo, Aurora, Castellano, Isabella, Riggi., Emilia, Casella, Denise, Pitarella, Sabina, Vergini, Viviana, Graewingholt, Axel, Lang, Kristina, and Falcini, Fabio
Published: 2024
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278. Teaching loss of brand control to engineering entrepreneurship students through analogical mapping

Author: Siano, Alfonso, Bertolini, Alessandra, Conte, Francesca, and Vollero, Agostino
Published: 2024
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279. Experimental measurements and numerical modelling of additively manufactured Fe-Si cores

Author: Stella, M., Faba, A., Fulginei, F. Riganti, Quercio, M., Scorretti, R., Bertolini, V., Sabino, L., Tiismus, H., Kallaste, A., and Cardelli, E.
Published: 2024
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280. 3D-printed and conventional provisional single crown fabrication on anterior implants: A randomized clinical trial

Author: de Souza, Fernanda Angeloni, Blois, Matheus Coelho, Collares, Kaue, and dos Santos, Mateus Bertolini Fernandes
Published: 2024
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281. The effect of lithium battery overpotential on sulfurized-polyacrylonitrile (SPAN): A theoretical approach

Author: Bertolini, Samuel, Venezuela, Pedro, and Delcorte, Arnaud
Published: 2024
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282. Constraints from LIGO O3 data on gravitational-wave emission due to r-modes in the glitching pulsar PSR J0537-6910

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Byer, R. L., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Cain III, H. W., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, J., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. 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C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G., Gemme, G., Gennai, A., George, J., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup., Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Sourath, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimes, E., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerrero, J. G., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. 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J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y. -W., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Inchauspe, H., Ingram, C., Inoue, Y., Intini, G., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jeon, C., Jeunon, M., Jia, W., Jiang, J., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, K., Jung, P., Junker, J., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. 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Subjects: Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract: We present a search for continuous gravitational-wave emission due to r-modes in the pulsar PSR J0537-6910 using data from the LIGO-Virgo Collaboration observing run O3. PSR J0537-6910 is a young energetic X-ray pulsar and is the most frequent glitcher known. The inter-glitch braking index of the pulsar suggests that gravitational-wave emission due to r-mode oscillations may play an important role in the spin evolution of this pulsar. Theoretical models confirm this possibility and predict emission at a level that can be probed by ground-based detectors. In order to explore this scenario, we search for r-mode emission in the epochs between glitches by using a contemporaneous timing ephemeris obtained from NICER data. We do not detect any signals in the theoretically expected band of 86-97 Hz, and report upper limits on the amplitude of the gravitational waves. Our results improve on previous amplitude upper limits from r-modes in J0537-6910 by a factor of up to 3 and place stringent constraints on theoretical models for r-mode driven spin-down in PSR J0537-6910, especially for higher frequencies at which our results reach below the spin-down limit defined by energy conservation., Comment: 28 pages, 19 figures, accepted in ApJ
Published: 2021
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283. The ultimate performance of the Rasnik 3-point alignment system

Author: van der Graaf, Harry, Bertolini, Alessandro, van Heijningen, Joris, Bouwens, Bram, Fortman, Nelson de Gaay, van der Reep, Tom, and Otemann, Lennart
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Rasnik system is a 3-point optical displacement monitor with sub-nanometer precision. The CCD-Rasnik alignment system was developed in 1993 for the monitoring of the alignment of the muon chambers of the ATLAS Muon Spectrometer at CERN. Since then, the development has continued as new CMOS imaging pixel chips became available. The system's processes and parameters that limit the precision have been studied in detail. We conclude that only the quantum fluctuations to which the light level content of sensor pixels are subject to, is limiting the spatial resolution. The results of two Rasnik systems are compared to results from simulations, which are in good agreement: the best reached precision of $\SI{7}{pm/\sqrt{Hz}}$ is reported. Finally, some applications of high-precision Rasnik systems are set out.
Published: 2021

284. Parameterized Hypercomplex Graph Neural Networks for Graph Classification

Author: Le, Tuan, Bertolini, Marco, Noé, Frank, and Clevert, Djork-Arné
Subjects: Computer Science - Machine Learning
Abstract: Despite recent advances in representation learning in hypercomplex (HC) space, this subject is still vastly unexplored in the context of graphs. Motivated by the complex and quaternion algebras, which have been found in several contexts to enable effective representation learning that inherently incorporates a weight-sharing mechanism, we develop graph neural networks that leverage the properties of hypercomplex feature transformation. In particular, in our proposed class of models, the multiplication rule specifying the algebra itself is inferred from the data during training. Given a fixed model architecture, we present empirical evidence that our proposed model incorporates a regularization effect, alleviating the risk of overfitting. We also show that for fixed model capacity, our proposed method outperforms its corresponding real-formulated GNN, providing additional confirmation for the enhanced expressivity of HC embeddings. Finally, we test our proposed hypercomplex GNN on several open graph benchmark datasets and show that our models reach state-of-the-art performance while consuming a much lower memory footprint with 70& fewer parameters. Our implementations are available at https://github.com/bayer-science-for-a-better-life/phc-gnn., Comment: 22 pages, 13 figures, preprint version including appendix. Artificial Neural Networks and Machine Learning. ICANN 2021
Published: 2021
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285. Impact of Local Energy Markets on the Distribution Systems: A Comprehensive Review

Author: Dudjak, Viktorija, Neves, Diana, Alskaif, Tarek, Khadem, Shafi, Pena-Bello, Alejandro, Saggese, Pietro, Bowler, Benjamin, Andoni, Merlinda, Bertolini, Marina, Zhou, Yue, Lormeteau, Blanche, Mustafa, Mustafa A., Wang, Yingjie, Francis, Christina, Zobiri, Fairouz, Parra, David, and Papaemmanouil, Antonios
Subjects: Electrical Engineering and Systems Science - Systems and Control
Abstract: In recent years extensive research has been conducted on the development of different models that enable energy trading between prosumers and consumers due to expected high integration of distributed energy resources. Some of the most researched mechanisms include Peer-to-Peer energy trading, Community Self-Consumption and Transactive Energy Models. Here, we present an exhaustive review of existing research around Local Energy Market integration into distribution systems, in particular benefits and challenges that the power grid can expect from integrating these models. We also present a detailed overview of methods that are used to integrate physical network constraints into the market mechanisms, their advantages, drawbacks, and scaling potential. We find that financial energy transactions do not directly reflect the physical energy flows imposed by the constraints of the installed electrical infrastructure. Therefore, ensuring the stable and reliable delivery of electricity, it is vital to understand the impact of these transactions on the grid infrastructure, e.g., impacts on the control, operation, and planning of electricity distribution systems., Comment: 27 pages, 4 tables, 4 figures
Published: 2021
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286. Search for anisotropic gravitational-wave backgrounds using data from Advanced LIGO and Advanced Virgo's first three observing runs

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. 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Subjects: General Relativity and Quantum Cosmology
Abstract: We report results from searches for anisotropic stochastic gravitational-wave backgrounds using data from the first three observing runs of the Advanced LIGO and Advanced Virgo detectors. For the first time, we include Virgo data in our analysis and run our search with a new efficient pipeline called {\tt PyStoch} on data folded over one sidereal day. We use gravitational-wave radiometry (broadband and narrow band) to produce sky maps of stochastic gravitational-wave backgrounds and to search for gravitational waves from point sources. A spherical harmonic decomposition method is employed to look for gravitational-wave emission from spatially-extended sources. Neither technique found evidence of gravitational-wave signals. Hence we derive 95\% confidence-level upper limit sky maps on the gravitational-wave energy flux from broadband point sources, ranging from $F_{\alpha, \Theta} < {\rm (0.013 - 7.6)} \times 10^{-8} {\rm erg \, cm^{-2} \, s^{-1} \, Hz^{-1}},$ and on the (normalized) gravitational-wave energy density spectrum from extended sources, ranging from $\Omega_{\alpha, \Theta} < {\rm (0.57 - 9.3)} \times 10^{-9} \, {\rm sr^{-1}}$, depending on direction ($\Theta$) and spectral index ($\alpha$). These limits improve upon previous limits by factors of $2.9 - 3.5$. We also set 95\% confidence level upper limits on the frequency-dependent strain amplitudes of quasimonochromatic gravitational waves coming from three interesting targets, Scorpius X-1, SN 1987A and the Galactic Center, with best upper limits range from $h_0 < {\rm (1.7-2.1)} \times 10^{-25},$ a factor of $\geq 2.0$ improvement compared to previous stochastic radiometer searches., Comment: 23 Pages, 9 Figures
Published: 2021
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287. Smooth determinantal varieties and critical loci in Multiview Geometry

Author: Bertolini, Marina, Notari, Roberto, and Turrini, Cristina
Subjects: Mathematics - Algebraic Geometry
Abstract: Linear projections from P^k to P^h appear in computer vision as models of images of dynamic or segmented scenes. Given multiple projections of the same scene, the identification of many enough correspondences between the images allows, in principle, to reconstruct the position of the projected objects. A critical locus for the reconstruction problem is a variety in P^k containing the set of points for which the reconstruction fails. Critical loci turn out to be determinantal varieties. In this paper we determine and classify all the smooth critical loci, showing that they are classical projective varieties.
Published: 2021

288. Suboccipital telovelar approach for microsurgical resection of a hemorrhagic brainstem cavernous malformation in an infant — how I do it

Author: Bertolini, Giacomo, Calamo Specchia, Francesco Maria, Bertolini, Patrizia, and Giombelli, Ermanno
Published: 2022
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289. Upper Limits on the Isotropic Gravitational-Wave Background from Advanced LIGO's and Advanced Virgo's Third Observing Run

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Byer, R. L., Cadonati, L., Caesar, M., Cagnoli, G., Cahillane, C., Cain III, H. W., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, J., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Champion, B., Chan, C. -H., Chan, C., Chan, C. L., Chan, M., Chandra, K., Chanial, P., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chen, A., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choate, S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y-K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colpi, M., Compton, C. M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Canton, T. Dal, Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danilishin, S. L., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dvorkin, I., Dwyer, S. E., Easter, P. J., Ebersold, M., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fishner, J. M., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G., Gemme, G., Gennai, A., George, J., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup., Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Sourath, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimes, E., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerrero, J. G., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J. N., Holgado, A. M., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y. -W., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Inchauspe, H., Ingram, C., Inoue, Y., Intini, G., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jeon, C., Jeunon, M., Jia, W., Jiang, J., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, K., Jung, P., Junker, J., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kwak, K., Kwang, S., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leon, E., Leonardi, M., Leroy, N., Letendre, N., Levin, Y., Leviton, J. N., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., Lollie, M. L., London, L. T., Longo, A., Lopez, D., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magazzù, C., Magee, R. M., Maggiore, R., Majorana, E., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., McCann, J. J., McCarthy, R., McClelland, D. E., McClincy, P., McCormick, S., McCuller, L., McGhee, G. I., McGuire, S. C., McIsaac, C., McIver, J., McManus, D. J., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Mishkin, A., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Nadji, S. L., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nocera, F., Noh, M., Norman, M., North, C., Nozaki, S., Nuttall, L. K., Oberling, J., O'Brien, B. D., Obuchi, Y., O'Dell, J., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Oram, R., O'Reilly, B., Ormiston, R. G., Ormsby, N. D., Ortega, L. F., O'Shaughnessy, R., O'Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Otabe, S., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, K., Panda, P. K., Pang, H., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Patricelli, B., Payne, E., Pechsiri, T. C., Pedraza, M., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C. J., Périgois, C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pilo, F., Pinard, L., Pinto, I. M., Piotrzkowski, B. J., Piotrzkowski, K., Pirello, M., Pitkin, M., Placidi, E., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Powell, J., Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Prestegard, T., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rapagnani, P., Rapol, U. D., Ratto, B., Raymond, V., Raza, N., Razzano, M., Read, J., Rees, L. A., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Relton, P., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Richardson, L., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rocha, J. A., Rodriguez, S., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, J. D., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Rose, C. A., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, Santosh, Roy, Soumen, Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O. S., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sassolas, B., Satari, H., Sato, S., Sato, T., Sauter, O., Savage, R. L., Savant, V., Sawada, T., Sawant, D., Sawant, H. L., Sayah, S., Schaetzl, D., Scheel, M., Scheuer, J., Schindler-Tyka, A., Schmidt, P., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schönbeck, A., Schulte, B. W., Schutz, B. F., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Seidel, E., Sekiguchi, T., Sekiguchi, Y., Sellers, D., Sergeev, A., Sengupta, A. S., Sennett, N., Sentenac, D., Seo, E. G., Sequino, V., Setyawati, Y., Shaffer, T., Shahriar, M. S., Shams, B., Shao, L., Sharifi, S., Sharma, A., Sharma, P., Shawhan, P., Shcheblanov, N. S., Shen, H., Shibagaki, S., Shikauchi, M., Shimizu, R., Shimoda, T., Shimode, K., Shink, R., Shinkai, H., Shishido, T., Shoda, A., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., ShyamSundar, S., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S. N., Somiya, K., Son, E. 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Subjects: General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO's and Advanced Virgo's third observing run (O3) combined with upper limits from the earlier O1 and O2 runs. Unlike in previous observing runs in the advanced detector era, we include Virgo in the search for the GWB. The results are consistent with uncorrelated noise, and therefore we place upper limits on the strength of the GWB. We find that the dimensionless energy density $\Omega_{\rm GW}\leq 5.8\times 10^{-9}$ at the 95% credible level for a flat (frequency-independent) GWB, using a prior which is uniform in the log of the strength of the GWB, with 99% of the sensitivity coming from the band 20-76.6 Hz; $\leq 3.4 \times 10^{-9}$ at 25 Hz for a power-law GWB with a spectral index of 2/3 (consistent with expectations for compact binary coalescences), in the band 20-90.6 Hz; and $\leq 3.9 \times 10^{-10}$ at 25 Hz for a spectral index of 3, in the band 20-291.6 Hz. These upper limits improve over our previous results by a factor of 6.0 for a flat GWB. We also search for a GWB arising from scalar and vector modes, which are predicted by alternative theories of gravity; we place upper limits on the strength of GWBs with these polarizations. We demonstrate that there is no evidence of correlated noise of magnetic origin by performing a Bayesian analysis that allows for the presence of both a GWB and an effective magnetic background arising from geophysical Schumann resonances. We compare our upper limits to a fiducial model for the GWB from the merger of compact binaries. Finally, we combine our results with observations of individual mergers andshow that, at design sensitivity, this joint approach may yield stronger constraints on the merger rate of binary black holes at $z \lesssim 2$ than can be achieved with individually resolved mergers alone. [abridged], Comment: 25 pages, 7 figures, Abstract abridged for arxiv submission
Published: 2021
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290. Constraints on cosmic strings using data from the third Advanced LIGO-Virgo observing run

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Auclair, P., Aufmuth, P., AultONeal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barnum, S., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. 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J., Richardson, J. W., Richardson, L., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rocha, J. A., Rodriguez, S., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero, A., Romero-Shaw, I. M., Romie, J. H., Rose, C. A., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, Santosh, Roy, Soumen, Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O. S., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sassolas, B., Satari, H., Sato, S., Sato, T., Sauter, O., Savage, R. L., Savant, V., Sawada, T., Sawant, D., Sawant, H. 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D., Telada, S., Tenorio, R., Terkowski, L., Test, M., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toland, K., Tolley, A. E., Tomaru, T., Tomigami, Y., Tomura, T., Tonelli, M., Torres-Forné, A., Torrie, C. I., Melo, I. Tosta e, Töyrä, D., Trapananti, A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsai, D. S., Tsai, D., Tsang, K. W., Tsang, T., Tsao, J-S., Tse, M., Tso, R., Tsubono, K., Tsuchida, S., Tsukada, L., Tsuna, D., Tsutsui, T., Tsuzuki, T., Turconi, M., Tuyenbayev, D., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Ueda, A., Uehara, T., Ueno, K., Ueshima, G., Ugolini, D., Unnikrishnan, C. S., Uraguchi, F., Urban, A. L., Ushiba, T., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., van Bakel, N., van Beuzekom, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., van Putten, M. H. P. M., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venneberg, J., Venugopalan, G., Verkindt, D., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Villa-Ortega, V., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., von Reis, E. R. G., von Wrangel, J., Vorvick, C., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J., Wang, J. Z., Wang, W. H., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watchi, J., Weaver, B., Wei, L., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilken, D., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Winkler, W., Wipf, C. C., Wlodarczyk, T., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wu, C., Wu, D. S., Wu, H., Wu, S., Wysocki, D. M., Xiao, L., Xu, W-R., Yamada, T., Yamamoto, H., Yamamoto, Kazuhiro, Yamamoto, Kohei, Yamamoto, T., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, L., Yang, Yang, Yang, Yi, Yang, Z., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Ying, M., Yokogawa, K., Yokoyama, J., Yokozawa, T., Yoon, A., Yoshioka, T., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhan, M., Zhang, H., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhao, C., Zhao, G., Zhao, Yue, Zhao, Yuhang, Zhou, Z., Zhu, X. J., Zhu, Z. -H., Zucker, M. E., and Zweizig, J.
Subjects: General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory
Abstract: We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 data set. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks and, for the first time, kink-kink collisions.cA template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension, $G\mu$, as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models.cAdditionally, we develop and test a third model which interpolates between these two models. Our results improve upon the previous LIGO-Virgo constraints on $G\mu$ by one to two orders of magnitude depending on the model which is tested. In particular, for one loop distribution model, we set the most competitive constraints to date, $G\mu\lesssim 4\times 10^{-15}$., Comment: 20 pages, 10 figures
Published: 2021
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291. Impact of Preprocessing Parameters in Medical Imaging-Based Radiomic Studies: A Systematic Review

Author: Valeria Trojani, Maria Chiara Bassi, Laura Verzellesi, and Marco Bertolini
Subjects: radiomics, preprocessing, biomarker, CT, MRI, CBCT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Lately, radiomic studies featuring the development of a signature to use in prediction models in diagnosis or prognosis outcomes have been increasingly published. While the results are shown to be promising, these studies still have many pitfalls and limitations. One of the main issues of these studies is that radiomic features depend on how the images are preprocessed before their computation. Since, in widely known and used software for radiomic features calculation, it is possible to set these preprocessing parameters before the calculation of the radiomic feature, there are ongoing studies assessing the stability and repeatability of radiomic features to find the most suitable preprocessing parameters for every used imaging modality. Materials and Methods: We performed a comprehensive literature search using four electronic databases: PubMed, Cochrane Library, Embase, and Scopus. Mesh terms and free text were modeled in search strategies for databases. The inclusion criteria were studies where preprocessing parameters’ influence on feature values and model predictions was addressed. Records lacking information on image acquisition parameters were excluded, and any eligible studies with full-text versions were included in the review process, while conference proceedings and monographs were disregarded. We used the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool to investigate the risk of bias. We synthesized our data in a table divided by the imaging modalities subgroups. Results: After applying the inclusion and exclusion criteria, we selected 43 works. This review examines the impact of preprocessing parameters on the reproducibility and reliability of radiomic features extracted from multimodality imaging (CT, MRI, CBCT, and PET/CT). Standardized preprocessing is crucial for consistent radiomic feature extraction. Key preprocessing steps include voxel resampling, normalization, and discretization, which influence feature robustness and reproducibility. In total, 44% of the included works studied the effects of an isotropic voxel resampling, and most studies opted to employ a discretization strategy. From 2021, several studies started selecting the best set of preprocessing parameters based on models’ best performance. As for comparison metrics, ICC was the most used in MRI studies in 58% of the screened works. Conclusions: From our work, we highlighted the need to harmonize the use of preprocessing parameters and their values, especially in light of future studies of prospective studies, which are still lacking in the current literature.
Published: 2024
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292. Proline Metabolism Genes in Transgenic Plants: Meta-Analysis under Drought and Salt Stress

Author: Marco Renzetti, Elisa Bertolini, and Maurizio Trovato
Subjects: proline metabolism genes, drought tolerance, salinity tolerance, transgenic plants, meta-analysis, Botany, QK1-989
Abstract: The amino acid proline accumulates in plants during abiotic stresses such as drought and salinity and is considered a reliable marker of environmental stress. While its accumulation is well established, its precise role in stress tolerance and its underlying molecular mechanism remain less clear. To address these issues, we performed a meta-analysis—a robust statistical technique that synthesizes results from multiple independent studies while accounting for experimental differences. We focused on 16 physiological and morphological parameters affected by drought and salt stress in transgenic plants expressing proline metabolic genes. For each parameter, we calculated the effect size as the response ratio (RR), which represents the logarithm of the mean value in the transgenic group over the mean value of the control group (lnRR). Under stress, most parameters exhibited significantly higher response ratios in the transgenic group, confirming the beneficial effects of proline during drought and salt stress. Surprisingly, under non-stressed conditions, most stress markers showed no significant differences between transgenic and non-transgenic plants, despite elevated proline levels in the former. These results suggest that the benefits of proline may be related to proline catabolism or may only become apparent during stress, possibly due to interactions with reactive oxygen species (ROS), which accumulate predominantly under stress conditions.
Published: 2024
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293. Adipose Tissue Derivatives in Peripheral Nerve Regeneration after Transection: A Systematic Review

Author: Rafael Silva de Araújo, Matheus Galvão Valadares Bertolini Mussalem, Gabriel Sant’Ana Carrijo, João Victor de Figueiredo Bani, and Lydia Masako Ferreira
Subjects: adipose tissue derivatives, adipose stem cells, microsurgery, nerve repair, nerve regeneration, functional analysis, Technology, Biology (General), QH301-705.5
Abstract: Introduction: Peripheral nerve injury (PNI) is increasingly prevalent and challenging to treat despite advances in microsurgical techniques. In this context, adipose tissue derivatives, such as adipose-derived stem cells, nanofat, and stromal vascular fraction have been gaining attention as potential allies in peripheral nerve regeneration. Objectives: This study aims to explore the use of adipose tissue derivatives in nerve regeneration following peripheral nerve transection in murine models. Thus, we assess and synthesize the key techniques and methods used for evaluating the obtained nerve regeneration to guide future experimental research and clinical interventions. Methodology: A systematic review was conducted in February 2024, adhering to the Cochrane and PRISMA 2020 guidelines, using the PubMed, SciELO, and LILACS databases. The focus was on experimental studies involving adipose tissue derivatives in nerve regeneration in animal models post-transection. Only experimental trials reporting nerve regeneration outcomes were included; studies lacking a comparator group or evaluation methods were excluded. Results: Out of 273 studies initially identified from MEDLINE, 19 were selected for detailed analysis. The average study included 32.5 subjects, with about 10.2 subjects per intervention subgroup. The predominant model was the sciatic nerve injury with a 10 mm gap. The most common intervention involved unprocessed adipose-derived stem cells, utilized in 14 articles. Conclusions: This review underscores the significant potential of current methodologies in peripheral nerve regeneration, particularly highlighting the use of murine models and thorough evaluation techniques.
Published: 2024
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294. STRILL: Phase I Trial Evaluating Stereotactic Body Radiotherapy (SBRT) Dose Escalation for Re-Irradiation of Inoperable Peripheral Lung Lesions

Author: Davide Franceschini, Mauro Loi, Antonio Marco Marzo, Luca Dominici, Ruggero Spoto, Anna Bertolini, Lorenzo Lo Faro, Francesco La Fauci, Beatrice Marini, Luciana Di Cristina, and Marta Scorsetti
Subjects: lung re-irradiation, stereotactic body radiation therapy, phase I, maximum tolerated dose, Medicine
Abstract: Few data are available on the role of SBRT re-irradiation for isolated recurrences. We designed a prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation, for peripheral lung lesions. RT was delivered with a dose escalation design from 30 Gy in five fractions up to 50 Gy in five fractions. The primary end point was the definition of the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. The dose-limiting toxicity was pneumonia ≥G3. Fifteen patients were enrolled. No cases of pneumonia ≥G3 occurred in any of our cohorts. Only one patient developed pneumonia G1 during treatment. Three patients developed acute toxicities that included dyspnea G1, cardiac failure G3, and chest wall pain. One patient developed G3 late toxicity with acute coronary syndrome. After a median follow-up of 21 months (range 3.6–29.1 months), six patients (40%) had a local relapse. Distant relapse occurred in five patients (33.3%). At the last follow-up, six patients died, all but two due to progressive disease. SBRT dose escalation for thoracic re-irradiation is an effective and well-tolerated option for patients with inoperable lung lesions after a first thoracic RT with acceptable acute and late toxicities.
Published: 2024
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295. Epidemic Information Extraction for Event-Based Surveillance using Large Language Models.

Author: Sergio Consoli, Peter Markov, Nikolaos I. Stilianakis, Lorenzo Bertolini, Antonio Puertas Gallardo, and Mario Ceresa
Published: 2024
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296. Digital Twin Generators for Disease Modeling.

Author: Nameyeh Alam, Jake Basilico, Daniele Bertolini, Satish Casie Chetty, Heather D'Angelo, Ryan Douglas, Charles K. Fisher, Franklin Fuller, Melissa Gomes, Rishabh Gupta, Alex H. Lang, Anton Loukianov, Rachel Mak-McCully, Cary Murray, Hanalei Pham, Susanna Qiao, Elena Ryapolova-Webb, Aaron M. Smith, Dimitri Theoharatos, Anil Tolwani, Eric W. Tramel, Anna Vidovszky, Judy Viduya, and Jonathan R. Walsh
Published: 2024
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297. BIOMERO: BioImage analysis in OMERO.

Author: Torec T. Luik, Rodrigo Rosas-Bertolini, Eric A. J. Reits, Ron A. Hoebe, and Przemek M. Krawczyk
Published: 2024
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298. Sharing sensitive data in life sciences: an overview of centralized and federated approaches.

Author: Maria A Rujano, Jan-Willem Boiten, Christian Ohmann, Steve Canham, Sergio Contrino, Romain David 0001, Jonathan Ewbank, Claudia Filippone, Claire Connellan, Ilse Custers, Rick van Nuland, Michaela Theresia Mayrhofer, Petr Holub, Eva García álvarez, Emmanuel Bacry, Nigel Hughes, Mallory Ann Freeberg, Birgit Schaffhauser, Harald Wagener, Alex Sánchez-Pla, Guido Bertolini, and Maria Panagiotopoulou
Published: 2024
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299. Rare Driver Mutations in Advanced, Oncogene-Addicted Non-Small Cell Lung Cancer: A North Italian, Real-World, Registry Experience

Author: Kalliopi Andrikou, Paola Ulivi, Elisabetta Petracci, Irene Azzali, Federica Bertolini, Giulia Alberti, Stefania Bettelli, Daniele Calistri, Elisa Chiadini, Laura Capelli, Paola Cravero, Giorgia Guaitoli, Francesca Zanelli, Marco Angelo Burgio, Maria Pagano, Alberto Verlicchi, Enrica Martinelli, Katia Di Emidio, Massimo Dominici, Carmine Pinto, and Angelo Delmonte
Subjects: NSCLC, oncogene addiction, inflammatory indexes, Medicine (General), R5-920
Abstract: The real-world, retrospective, NEROnE registry investigated the impact of next-generation sequencing (NGS) in advanced non-small-cell lung cancer (NSCLC) patients (pts) at three oncology units in the north of Italy between January 2020 and December 2022. We focused on the clinical characterization and outcomes of NSCLC with rare molecular alterations: EGFR exon 20 insertion, non-activating EGFR mutations, BRAF V600E and non-V600, ROS1 and RET rearrangements, MET, ErbB2, and FGFR mutations. Overall, these represented 6.4% (62/970) of the pts analysed with NGS in the daily practice. The most heavily represented rare alterations were ROS1 rearrangement (15 pts—24%) and MET exon 14 skipping mutation (11 pts—18%). No associations were found with the demographic and clinical features. Forty-nine pts received targeted therapies, of which 38.8% were first- and 9.8% were second-line. The remaining pts received chemotherapy and/or immunotherapy. In terms of the clinical outcomes, although not statistically significant, a tendency toward shorter OS was seen when therapies other than specific targeted therapies were used (HR: 1.84, 95% CI: 0.79–4.33, p = 0.158). The pts with co-mutations (19.4%) seemed to receive an advantage from the front-line chemotherapy-based regimen. Finally, an NLR score (a well-known inflammatory index) ≥ 4 seemed to be related to shorter OS among the pts treated with immunotherapy alone or in combination with chemotherapy (HR: 2.83, 95% CI: 1.08–7.40, p = 0.033). Prospective evaluations need to be performed to clarify whether these indexes may help to identify patients with oncogene-addicted NSCLC who could benefit from immunotherapy.
Published: 2024
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300. Modeling Disease Progression in Mild Cognitive Impairment and Alzheimer's Disease with Digital Twins

Author: Bertolini, Daniele, Loukianov, Anton D., Smith, Aaron M., Li-Bland, David, Pouliot, Yannick, Walsh, Jonathan R., and Fisher, Charles K.
Subjects: Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract: Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments. As clinical trials in AD increasingly focus on earlier stages of the disease, especially Mild Cognitive Impairment (MCI), the ability to model subject outcomes across the disease spectrum is extremely important. We use unsupervised machine learning models called Conditional Restricted Boltzmann Machines (CRBMs) to create Digital Twins of AD subjects. Digital Twins are simulated clinical records that share baseline data with actual subjects and comprehensively model their outcomes under standard-of-care. The CRBMs are trained on a large set of records from subjects in observational studies and the placebo arms of clinical trials across the AD spectrum. These data exhibit a challenging, but common, patchwork of measured and missing observations across subjects in the dataset, and we present a novel model architecture designed to learn effectively from it. We evaluate performance against a held-out test dataset and show how Digital Twins simultaneously capture the progression of a number of key endpoints in clinical trials across a broad spectrum of disease severity, including MCI and mild-to-moderate AD.
Published: 2020

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