1,114 results on '"Beglinger, C"'
Search Results
252. Effect of exocrine pancreatic secretagogues on circulating somatostatin in dogs.
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BEGLINGER, C., RIBES, G., WHITEHOUSE, I., LOUBATIERES-MARIANI, M. M., GRÖTZINGER, U., and GYR, K.
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- 1986
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253. Helicobacter pylori infection in the young in Bangladesh: prevalence, socioeconomic and nutritional aspects.
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MAHALANABIS, DILIP, RAHMAN, MOHAMMED M, SARKER, SHAFIQUL A, BARDHAN, PRADIP K, HILDEBRAND, PIUS, BEGLINGER, CHRIS, GYR, KLAUS, Mahalanabis, D, Rahman, M M, Sarker, S A, Bardhan, P K, Hildebrand, P, Beglinger, C, and Gyr, K
- Abstract
Background: The gastric acid barrier, an important host defence against small bowel infection, may be compromised by infection with Helicobacter pylori. In developing countries, H. pylori infection occurs early in life and prevalence of hypochlorhydria is high particularly in the malnourished, which may predispose a child to repeated gastrointestinal infection and diarrhoea. Diarrhoea being a leading cause of childhood mortality and morbidity in developing countries, we investigated the prevalence of H. pylori infection in children in a poor Bangladeshi community and explored its association with socioeconomic and nutritional status.Methods: The study was conducted in a poor periurban community among 469 children aged 1-99 months. Parents were interviewed using a questionnaire. To detect active infection with H. pylori a 13C-urea breath test was performed and weight was recorded on a beam balance with a sensitivity of 20 g.Results: In all, 61% of 36 infants aged 1-3 months were positive for H. pylori; this rate dropped steadily with increasing age and was 33% in 10-15 month old children and then rose to 84% in 6-9 year olds. Overall H. pylori infection had no association with nutritional state of the child, or family income but the infection rate was 2.5 times higher in children of mothers with no schooling.Conclusions: The H. pylori infection rate is very high in early infancy in a poor periurban community of Bangladesh. The reason for a drop in the infection rate in late infancy is unclear but could be due to initial clearance of the infection by the body's defence mechanisms but with possible alteration of the gastric mucosa which sustains infection. Maternal education may be protective and may operate through some unidentified proximate behavioural determinants. The rate of H. pylori infection in infants and young children may predispose them to repeated gastrointestinal infection and diarrhoea. [ABSTRACT FROM AUTHOR]- Published
- 1996
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254. Reduction in Early Recurrence of Variceal Bleeding by Propranolol.
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Marbet, U. A., Straumann, A., Gyr, K. E., Beglinger, C., Schaub, N., Vögtlin, J., Loosli, J., Kiowski, W., Ritz, R., and Stalder, G. A.
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- 1988
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255. Human Pharmacological Effects of SMS 201-995 on Gastric Secretion.
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Gyr, K. E., Whitehouse, I., Beglinger, C., Köhler, E., Dettwiler, S., and Fried, M.
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- 1986
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256. Influence of age, gender, hormonal status and smoking habits on colonic transit time.
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Meier, Rémy, BEGLINGER, C., DEDERDING, J. P., MEYER-WYSS, B., FUMAGALLI, M., ROWEDDER, A., TURBERG, Y., and BRIGNOLI, R.
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- 1995
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257. Therapeutic effects of loxiglumide, a cholecystokinin antagonist, on chronic constipation in elderly patients: a prospective, randomized, double-blind, controlled trial.
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MEIER, R., BEGLINGER, C., THUMSHIRN, M., MEYER, B., ROVATI, L. C., GIACOVELLI, G., D'AMATO, M., and GYR, K.
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- 1993
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258. Intracolonic bioavailability of human calcitonin in man.
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Beglinger, C., Born, W., Muff, R., Drewe, J., Dreyfuss, J., Bock, A., Mackay, M., and Fischer, J.
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Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to intravenously administered hCT (area under the concentrationtime curve). With intravenous hCT serum calcium was lowered and the fractional urinary excretion of calcium, phosphorus, sodium and chloride was significantly stimulated. With the intracolonic hCT, the fractional urinary excretions of calcium, sodium and chloride were also marginally stimulated relative to intracolonic vehicle (placebo). In conclusion, hCT is absorbed intact from the colon, but the bioavailability is low and highly variable. [ABSTRACT FROM AUTHOR]
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- 1992
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259. Calcitonin gene-related peptide (CGRP) causes redistribution of blood flow in humans.
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Jäger, K., Muench, R., Seifert, H., Beglinger, C., Bollinger, A., and Fischer, J.
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In normal human subjects ( n=6), blood flow in the common carotid artery, assessed with an ultrasonic duplex-scanning unit, was increased up to 152% of basal levels by 60-min infusions of human calcintonin gene-related peptide I (αCGRP) 80 pmol·kg·h, but it was not affected by 20 pmol·kg·h CGRP or 88 pmol·kg·h human calcitonin. In the superior mesenteric artery, on the other hand, blood flow was reduced by 80 pmol·kg·h CGRP to 58% of the basal level, but not by 20 pmol·kg·h CGRP or with 88 pmol·kg·h calcitonin. Blood flow in the abdominal aorta remained largely unchanged under the same conditions. Skin blood flow, assessed by a laser Doppler unit, was increased up to 682% of the basal level by 80 pmol·kg·h CGRP, but not by 20 pmol·kg·h CGRP or calcitonin. Thus CGRP increased regional blood flow to the brain and the skin at the expense of the gastrointestinal tract. [ABSTRACT FROM AUTHOR]
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- 1990
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260. Absorption of an aqueous solution of a new synthetic somatostatin analogue administered to man by gavage.
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Köhler, E., Duberow-Drewe, M., Drewe, J., Ribes, G., Loubatières-Mariani, M., Mazer, N., Gyr, K., and Beglinger, C.
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To determine the local gastrointestinal absorption of a new synthetic somatostatin analogue (SMS 201-995 = Sandostatin), an intestinal tube was passed in eight healthy volunteers and on different days an aqueous solution was administered at four different locations: stomach, proximal duodenum, ligament of Treitz and jejunum. In a follow-up study, an oro-ileal tube was passed in six of the original volunteers and the drug solution was administered in to the terminal ileum. The aqueous solution of SMS was rapidly absorbed from the gastrointestinal tract after local application, and it was well tolerated. Absorption of the drug from the different sites was comparable, although there was a tendency to decreased peptide absorption after ileal administration. Absorption of the drug was quite variable between the subjects and the different locations. The dose-corrected systemic availability relative to subcutaneous administration in another study was 0.28%. However, significant plasma SMS concentrations were achieved, suggesting that oral delivery of the polypeptide may eventually be possible for long-term treatment of a variety of disorders. [ABSTRACT FROM AUTHOR]
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- 1987
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261. Specific activation of AP-1 but not Stat3 in regenerating liver in mice.
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HEIM, M. H., GAMBONI, G., BEGLINGER, C., and GYR, K.
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- 1997
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262. Identification of functional GRP-preferring bombesin receptors on human melanoma cells.
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Pansky, A., Peng, F., Eberhard, M., Baselgia, L., Siegrist, W., Baumann, J. B., Eberle, A. N., Beglinger, C., and Hildebrand, P.
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- 1997
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263. Intestinal phase of human antro-pyloro-duodenal motility: cholinergic and CCK-mediated regulation.
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KATSCHINSKI, M., SCHIRRA, J., BEGLINGER, C., LANGBEIN, S., WANK, U., D'AMATO, M., and ARNOLD, R.
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- 1996
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264. Hormones as regulators of pancreatic secretion in man.
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ADLER, G. and BEGLINGER, C.
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- 1990
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265. Stimulation of pancreatic secretion in man by a protease inhibitor (camostate).
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ADLER, G., MÜLLENHOFF, A., KOOP, I., BOZKURT, T., GÖKE, B., BEGLINGER, C., and ARNOLD, R.
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- 1988
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266. Helicobacter pylori colonization in infants and young children is not necessarily associated with diarrhoea.
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Rahman, M. M., Mahalanabis, D., Sarker, S. A., Bardhan, P. K., Alvarez, J. O., Hildebrand, P., Beglinger, C., Gyr, Klaus, and Gyr, K
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- 1998
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267. Comparison of the Effects of the M1-Receptor Antagonist Telenzepine and the CCK-Receptor Antagonist Loxiglumide on the Pancreatic Secretory Response to Intraduodenal Tryptophan in Dogs.
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Teyssen, S., Niebergall-Roth, E., Rausch, A., Beglinger, C., Riepl, R. L., Chari, S., and Singer, M. V.
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- 1996
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268. What Is the Maximal Effective Dose of Caerulein in Stimulating Pancreatic Secretion in Man?
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Beglinger, C., Köhler, E., Stalder, G.A., Jansen, J., and Gyr, K.
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- 1986
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269. The Effect of Adding Albumin to Solutions of Somatostatin (SST-14) on Inhibiting Pentagastrin-Stimulated Acid Secretion in Man.
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Whitehouse, I., Beglinger, C., Bally, H., and Gyr, K.
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- 1986
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270. The Release of Pancreatic Polypeptide by Exogenous CCK in Man and Dog.
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Beglinger, C., Meyer, F., Häcki, W., and Gyr, K.
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- 1981
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271. Induction of the fed pattern of human exocrine pancreatic secretion by nutrients: role of cholecystokinin and neurotensin.
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Katschinski, M., Dippel, C., Reinshagen, M., Schirra, J., Arnold, R., Nustede, R., Beglinger, C., and Adler, G.
- Abstract
The aim of the present study was to assess the role of cholecystokinin and neurotensin in converting the cyclical interdigestive pattern of pancreatic secretion into the non-cyclical fed pattern. Six healthy male volunteers were studied on 4 separate days. During each experiment a mixed liquid meal or solutions of individual nutrients were perfused intraduodenally for 180 min at 2 ml/min. The mixed meal contained 4.3 g glucose, 2.0 g fractionated soya oil, and 1.7 g casein hydrolysate per 100 ml, which delivered a caloric load of 0.9 kcal/min into the duodenum. The isocaloric and isotonic solutions of individual nutrients contained 44.5 g glucose, 17.8 g fractionated soya oil, or 44.5 g hydrolysed serum bovine albumin per liter and delivered 0.36 kcal/min into the duodenum. Duodenal aspirates and blood samples were collected at regular intervals for determination of pancreatic enzyme outputs and plasma levels of cholecystokinin and neurotensin, respectively. The mixed meal converted the cyclical interdigestive secretory pattern into the noncyclical fed pattern whereas none of the three individual nutrients abolished the interdigestive pattern. Not only the mixed meal but also lipid and protein perfusion consistently stimulated cholecystokinin release. Integrated incremental cholecystokinin release amounted to 32.3±9.9 pg/ml × 180 min with the mixed meal, 23.2±6.5 with lipid perfusion ( P< 0.05 versus mixed meal) and 13.4±3.8 with protein perfusion ( P<0.05 versus mixed meal). The carbohydrate solution did not significantly release cholecystokinin. None of the duodenal perfusates raised neurotensin plasma levels. We conclude that (a) intraduodenal delivery of a mixed meal at 0.9 kcal/min converts the interdigestive pattern of pancreatic secretion, (b) cholecystokinin but not neurotensin is involved in converting this pattern in response to low-caloric meals, and (c) a threshold amount of CCK release must be exceeded to convert the secretory pattern. [ABSTRACT FROM AUTHOR]
- Published
- 1992
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272. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
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Straumann, A., Spichtin, H.p., Grize, L., Bucher, K.A., Beglinger, C., and Simon, H.u.
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Background & Aims: Primary eosinophilic esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus. The leading symptom in adults is uniform attacks of dysphagia, and the established histologic sign is a dense eosinophilic infiltration of the esophageal epithelium. Before this study, the natural course of eosinophilic esophagitis had not been defined and information regarding potential long-term risks was lacking. Methods: This prospective case series included 30 adult patients with eosinophilic esophagitis (22 men and 8 women; mean age, 40.6 years) whose diagnosis had been made >1 year before study debut based on typical history, consistent endoscopic abnormalities, and infiltration of the esophageal epithelium with >24 eosinophils/high-power field. After a mean of 7.2 years, patients underwent a comprehensive follow-up examination. Results: All patients survived the study period in good health and stable nutritional state. Dysphagia persisted in 29 patients, exerting a major negative effect on socioprofessional activities on 1 patient and a minor impact on 15. Attacks of dysphagia were more frequent in patients with blood eosinophilia or pronounced endoscopic alterations. The esophageal eosinophilic infiltration persisted in all symptomatic patients, but cell numbers spontaneously decreased significantly (78.7 vs. 40.3 cells/high-power field). The inflammatory process evoked fibrosis of the esophageal lamina propria but did not spread to the stomach or duodenum. No case evolved to a hypereosinophilic syndrome. Conclusions: Eosinophilic esophagitis, a primary and chronic disease restricted to the esophagus, leads to persistent dysphagia and structural esophageal alterations but does not impact the nutritional state. To date, no malignant potential has been associated with this disease.
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- 2003
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273. Fragility of the esophageal mucosa: A pathognomonic endoscopic sign of primary eosinophilic esophagitis?
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Straumann, A., Rossi, L., Simon, H.-U., Heer, P., Spichtin, H.-P., and Beglinger, C.
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Background: Primary eosinophilic esophagitis, a chronic inflammatory disorder of the esophagus, evokes recurrent dysphagia. Endoscopy is often unremarkable, and no consensus exists regarding management of resultant dysphagia. The response of a series of patients with primary eosinophilic esophagitis to dilation is reported together with a description of a possibly pathognomonic sign: fragile esophageal mucosa, for which the term ''crepe-paper'' mucosa is introduced. Methods: Five men underwent endoscopy because of dysphagia confirmed (clinically, endoscopically, and histologically) to be caused by primary eosinophilic esophagitis and were treated by bouginage. Observations: All patients had extremely fragile, inelastic, and delicate mucosa, which tore easily even with minor trauma. After the procedure, patients remained asymptomatic for 3 to 24 months. Conclusions: Primary eosinophilic esophagitis is characterized by fragile esophageal mucosa that readily tears in response to minor trauma during otherwise uneventful diagnostic endoscopy. This ''crepe-paper'' sign may alert endoscopists to the presence of the disease when other mucosal alterations are lacking. Dilation is effective for patients with symptoms with minimal morbidity, despite development of disquieting lesions in response to the procedure.
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- 2003
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274. The release of pancreatic polypeptide by CCK-octapeptide and some analogues in the dog
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Dieter Gillessen, Beglinger C, G.A. Stalder, Gyr K, F. D. Meyer, W.H. Hacki, L. Varga, L. Jeker, and L. Kayasseh
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Methoxinine ,medicine.medical_specialty ,Methionine ,Hepatology ,Chemistry ,digestive, oral, and skin physiology ,Gastroenterology ,Stimulation ,Radioimmunoassay ,chemistry.chemical_compound ,Pancreatic secretion ,Endocrinology ,Internal medicine ,medicine ,Potency ,Pancreatic polypeptide ,hormones, hormone substitutes, and hormone antagonists ,Cholecystokinin - Abstract
In dogs with gastric and pancreatic Thomas fistulas the effect of different cholecystokinin-like peptides upon pancreatic polypeptide (PP) release was studied in three ways: (a) Plasma PP concentrations were determined by radioimmunoassay in response to 135 pmol/kg/h of the synthetic C-terminal octapeptide of cholecystokinin (CCK-OP) (A), of three of its analogues (B, C, D) where methionine has been replaced by methoxinine, and in response to 45 pmol/kg/h of caerulein. The greatest rise in plasma PP concentration expressed as ΔPP was achieved with caerulein (327 ± 37 pM), when taking into account the threefold smaller dose used, followed by CCK-OP (536 ± 67 pM) and analogues B (343 ± 51 pM), C (87 ± 46 pM), and D (32 ± 15 pM). The order of potency with respect to stimulation of exocrine pancreatic secretion was the same: E and A precede B, C, and D. ΔPP correlated linearly with the pancreatic protein output (r = 0.98, p
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- 1981
275. The effect of cholecystokinin in controlling appetite and food intake in humans
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Degen, L., Matzinger, D., Drewe, J., and Beglinger, C.
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- 2001
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276. Stem cell transplantation for inflammatory bowel disease: practical and ethical issues.
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Hawkey, C J, Snowden, J A, Lobo, A, Beglinger, C, and Tyndall, A
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- 2000
277. Urinary Choloyl-PABA Excretion in Diagnosing Small Intestinal Bacterial Overgrowth
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Bardhan, Pradip, Feger, Alain, Kogon, Manuela, Muller, Jan, Gillessen, Dieter, Beglinger, C., and Gyr, Niklaus
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The synthetic substrate cholyl-PABA, developed by conjugating cholic acid with paraaminobenzoic acid, is hydrolyzed by the bacterial enzyme cholyl hydrolase to release free PABA. This study aimed to evaluate whether quantitating urinary excretion of PABA after oral administration of cholyl-PABA can detect small intestinal bacterial overgrowth. In the first phase, investigations were performed on 10 healthy volunteers to study the dynamics of urinary excretion of PABA and any adverse reactions after oral administration of 1.2 g of cholyl-PABA. Another 10 healthy volunteers and 25 adult patients with various gastrointestinal disorders participated in the second phase, where the urinary cholyl-PABA test was compared to the [14C]xylose breath test (XBT). The upper limit of normal levels of urinary PABA excretion at the end of 4 h was 1.1% of the administered dose of cholyl-PABA. The urinary PABA excretion after 4 hr [median (range), in percentage] in the XBT-positive group was 1.6 (0.6–35.0), which was significantly higher than those in the XBT-negative group [0.7 (0.4–1.8)] and the healthy controls [0.7 (0.2–1.1)]. The agreement between the XBT and the urinary cholyl-PABA test was 85.7% (P< 0.01). No adverse effect was noted. In conclusion, the urinary cholyl-PABA test offers a simple, safe, noninvasive, and rapid method for diagnosing small intestinal bacterial overgrowth and warrants further clinical evaluation.
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- 2000
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278. Progressive development of diffuse liver hemangiomatosis
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Lehmann, F. S., Beglinger, C., Schnabel, K., and Terracciano, L.
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- 1999
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279. HIV protease inhibitor ritonivar: A more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833
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Drewe, J., Gutmann, H., Fricker, G., Toeroek, M., Beglinger, C., and Huwyler, J.
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- 1999
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280. 35th Annual Meeting of the European Association for the Study of Diabetes
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y.-S., Sternesjö, J., Sandler, S., Chen, M.-C., Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Bréant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., van der Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, De Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessières-Lacombe, S., Tauber, J.-P., Home, P. D., Lindholm, A., Riis, A., Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Steiner, G., Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Vergès, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph., Benko, B., Ljubić, S., Turk, Z., Granić, M., März, W., Wollschläger, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O’Rahilly, S., Hattersley, A. T., McCarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., de Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. 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H., Telting, D., van der Zon, G. C. M., Dorrestijn, J., Maassen, J. A., Clapham, J. C., Holder, J. C., Tomlinson, K. M., Pickavance, L., Buckingham, R., Wilding, J., Jacinto, S. M., Harrold, J., Ljung, B., Kjellstedt, A., Thalén, P., Widdowson, P., Williams, G., Oakes, N., Aoki, K., Saito, T., Satoh, S., Mukasa, K., Kaneshiro, M., Kawasaki, S., Hoshino, K., Okamura, A., Sekihara, H., Smith, U., Johansson, A., Nilsson, E., Olausson, T., Nakazawa, T., Suzuki, M., Martinez, J., Murado, P., Azal, Ö., Yönem, A., Çakır, B., Polat, Z., Kutlu, M., Çorakçı, A., Bayraktar, M., Gürlek, A., Koray, Z., Damian, M. S., Linn, T., Laube, H., Arzner, S., Meißner, H.-P., Giunti, S., Comune, M., Cassader, M., Conte, M. R., Sacchi, C., Musso, G., Mecca, F., Depetris, N., Gambino, R., Perin, P. Cavallo, Kawakami, S., Sandqvist, M., Jansson, P.-A., Šindelka, G., Widimský, J., Haas, T., Prázný, M., Mari, A., Nolan, J. J., Uusitupa, M. I. J., Karşıdağ, K., Hacıhanefioğlu, B., Dinççağ, N., Drivsholm, T., Palacios, R. T., Vølund, A., Pedersen, Oluf B., Letiexhe, M. R., Scheen, A. J., Quiñones Galvan, A., Simeoni, M., Basu, A., Uosukainen, A., Mäkimattila, S., Schlenzka, A., Adler, A. I., Levy, J., Stevens, R., Matthews, D., Holman, R., Boland, B. J., Jeanjean, M., Hermans, M. P., Maudoigt, C., Tonglet, R., Robert, A., Quiñones-Galvan, A., Cini, G., Galetta, F., Sanna, G., Gernone, F., Janssen, M. J., Gonera, R. K., Wolffenbuttel, B. H. R., de Leeuw, P. W., Schaper, N. C., Molęda, P., Kuczerowski, R., Czech, A., Tatoń, J., Taddei, S., Patiag, D., Qu, X., Wilkes, M., Gray, S., Seale, J. P., Donnelly, R., Campión, J., Maestro, B., Dávila, N., Carranza, M. C., Calle, C., Hales, C. N., Fernández-Real, J. M., Grasa, M., Pugeat, M., Barret, C., Ricart, W., Lindmark, S., Olsson, T., Tufvesson, M., Loeblein, K., Mehnert, B., Haering, H. U., Rave, Klaus, Heise, Tim, Clauson, Per, Hirschberger, Sabine, Heinemann, Lutz, Claret, M., Nadal, B., Truc, A., Rossi, L., Hildebrand, P., Ketterer, S., Beglinger, C., Keller, U., Gyr, K., Parvin, S., Overkamp, D., Vayreda, M., González-Huix, F., G-Huix, F., Zavaroni, I., Gasparini, P., Massironi, P., Zuccarelli, A., Delsignore, R., Reaven, G. M., Sheu, W. H. H., Lee, W. J., Chen, Y.-T., Iraklianou, S., Tournis, S., Volonakis, I., Spylopoulou, M., Bilianou, E., Melidonis, A., Foussas, S., Güler, Serdar, çakir, Bekir, Demi̇rbaş, Berrin, Gürsoy, Gül, Serter, Rüştü, Aral, Yalçin, Morton, G., Lee, S., Fahey, R., de Silva, A., Cai, X. J., Buckingham, R. E., Arch, J. R. S., Wilson, S., Clausen, J. T., Kristensen, P., Nielsen, P. F., Wulff, B. S., Thim, L., Holness, M. J., Sugden, M. C., Fryer, L. G. D., Munns, M. J., Mannucci, E., Ognibene, A., Cremasco, F., Bardini, G., Mencucci, A., Ciani, S., Pierazzuoli, E., Tsuchihashil, K., Rigalleau, V., Delafaye, C., Baillet, L., Vergnot, V., Brunou, P., Gatta, B., Gin, H., Felber, J. P., Munger, R., Assimacopoulos, F., Bobbioni, E., Golay, A., Wilken, M., Larsen, F. S., Buckley, D., Molina, L. M., Marquez, L., Arbeo, A., Hernandez, C., Kofod, H., Damholt, A. B., Buchan, A., Márquez, L., Luque, M. A., Sarti, L., Sutton, P. J., Behle, K., Heimesaat, M. M., Hüfner, M., Gravholt, Claus Højbjerg, Mølier, Niels, Christiansen, Jens Sandahl, Schmitz, Ole, Deacon, C. F., Brock, B., Knudsen, L. B., Agersø, H., Huusfeldt, P. O., Kelly, C. M. N., Brunn, C., Schioos, J., Sewing, S., Lemansky, P., Wawro, S., Mest, H. J., Taguchi, T., Motoshima, H., Yoshizato, K., Guenifi, Amel, Henriksson, M., Johansson, J., Shafqat, J., Tally, M., Wahren, J., Jömvall, H., Ekberg, K., Rigler, R., Pramanik, A., Kratz, G., Johansson, B.-L., Uhlén, M., Jörnvall, H., Forst, T., Dufayet De La Tour, D., Kunt, T., Pfützner, A., Goitom, K., Pohlmann, T., Schneider, S., Johansson, B. L., Löbig, M., Engelbach, M., Beyer, J., Ekman, Bertil, Nyström, Fredrik, Arnqvist, Hans J., Halvatsiotis, P. G., Meek, S., Bigelow, M., Nair, K. S., Maghsoudi, S., Fisker, S., Vølund, A. A., Jörgensen, J. O. L., Christiansen, J. S., Hilsted, J., Mazerkina, N. A., Tiulpakov, A. N., Gorelyshev, S. K., Peterkova, V. A., Macut, D. J., Dieguez, C., Casanueva, F. F., Catalina, P. F., Mallo, F., Andrade, A., García-Mayor, R. V. G., Popova, V. V., ter Maaten, J. C., Popp-Snijders, C., Madsen, L., Ukropec, J., Bergene, E., Rnstan, A. C., Berge, R., Arner, P., Wahl, G., Häring, H., Bryson, J. M., Curtis, S. E., Caterson, I. D., Winzell, M. Sörhede, Svensson, H., Ahnén, B., Holm, C., Phillips, C., Madigan, C., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Cabezas, M. Castro, van Oostrom, A. J. H. H. M., Erkelens, D. W., Summers, L. K. M., Fielding, B. A., Ilic, V., Clark, M. L., Frayn, K. N., Pietzsch, J., Julius, U., Nitzsche, S., Fischer, S., Lindgren, C., Amrot-Fors, L., Hoffmann, M. M., Luft, D., Schmülling, R.-M., D’Adamo, M., Leonetti, F., Paoloni, A., Ribaudo, M. C., Basso, M. S., Elmore, U., Restuccia, A., Sbraccia, P., Emilsson, V., O’Dowd, J., Heyman, R., Cawthorne, M. A., Pelikánová, T., Kazdová, L., Žák, A., Chvojková, Š., Özer, E. M., Kadıoğlu, P., Korugan, Ü., Hatemi, H., Rivellese, A. A., Dullaart, R. P. F., Riemens, S. C., Sluiter, W. J., van Tol, A., Farnier, M., Megnien, S., Turpin, G., Stulp, B. K., Brambilla, P., Brunelli, A., Riva, M. C., Manzoni, P., de Poli, S., Riboni, S., Stolk, R. P., Meijer, R., Wink, O., Zelissen, P. M. J., van Gils, A. P. G., Grobbee, D. 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W., Taverna, M., Guerre-Millo, M., Chevalier, A., Pacher, N., Slama, G., Gorshunska, M., Buyken, A. E., Heitkamp, G., Kabir, M., Oppert, J. M., Wursch, P., Bruzzo, F., Rahman, M. H., Fatima, K., Ahmed, S., Mondal, H. N., Yilmaz, M., Öztok, U., Karakoç, A., Çakır, N., Düzgün, E., Yetkin, İ., Arslan, M., Şardaş, S., Wilding, John, Géloën, A., Baret, G., Dalmaz, Y., Peyronnet, J., Clémenceau, B., Martignat, L., Lalain, S., Gouin, E., Kenda-Ropson, N., Miller, A. O. A., You, S., Aguilera, E., Recasens, M., Flores, L., Ricart, M. J., Fernández-Cruz, L., Esmatjes, E., Crenier, L., Noël, C., Le Moine, A., Mahy, M., Danguy, A., Kiss, R., Goldman, M., Bracci, C., De Haan, B., Nilsson, K., Deschamps, J. Y., Glagoličová, A., Smrčková, I., Dieterle, C., Illner, W. D., Land, W., Feldmeier, H., Scheuer, R., Lalli, C., Di Loreto, C., Ellringmann, U., Balks, H. J., v. zur Mühlen, A., Dengler, R., Weissenborn, K., Rasmussen, B. M., Ørskov, L., Watson, J., Owen, G., Barrett, G., Ingleby, J., Weiss, M., Deary, I., Cavan, D., Kerr, D., Bruneiii, A., Cuce’, A., Elsing, H. G., Kühne, D., Quinn, N. D., Warner, D. P., Buysschaert, M., Jamal, R., O’Brien, T., Latare, P., Mullen, J., Rein, A., Wargo, M., Parkes, J. L., Ginsberg, B., Sotiropoulos, A., Peppas, Th. A., Kotsini, V., Apostolou, O., Bousboulas, S., Michailidis, E., Sawala, M., Pappas, S., Nilsson, P. M., Nilsson, J. Å., Berglund, G., Molins, T., Esteban, J. I., Genescà, J., Paris, I., Haufroid, V., Selvais, Ph., Petit, J. M., Duong, M., Grappin, M., Guiguet, M., Rudoni, S., Portier, H., Brun, J. M., Bagg, W., Plank, L., Drury, P. L., Sharpe, N., Braatvedt, G. D., Carrascosa, J. M., Molero, J. C., Fermίn, Y., Andrés, A., Satrústegui, J., Rietzsch, H., Patzak, A., Schwanebeck, U., Simpson, H., Robertson-Mackay, F., Montegriffo, E., Fox, C., Chiasson, J.-L., Josse, R. G., Dorman, J. M., Gerstein, H. C., Lau, D., Leiter, L. A., Maheux, P., Meneilly, G. S., Murphy, L., Rodger, N. W., Ross, S. A., Ryan, E., Yale, J.-F., Wolever, T. M. S., Haller, T., Elias, I., Segal, P., Standi, E., Rybka, J., Sencer, E., Satman, I., Schlcnzka, A., Vakkilainen, J., Tsaglis, H., Ioannidis, I., Giakoumaki, A., Amantou, A., Komitopoulos, N., Georgiou, S., Varsamis, E., Katsilambros, N., El Gayar, M., Shereba, N., Botros, R., Fikry, R., Jackson, D., Balme, M., Silva-Nunes, J., Alves, J., Bogalho, P., Gardete-Correia, L., Nunes-Corrêa, J., Kot’átková, A., Němcová, D., Vrbíková, J., Zamrazil, V., Meyer, L., Delbachian, I., Lehert, P., Cugnardey, N., Drouin, P., Guerci, B., Wagner, O. F., Jones, N. P., Vallance, S. E., Thompson, K. A., Miller, A. K., Inglis, A. M. L., Patterson, S., Jorkasky, D., Freed, M. I., Mathisen, A. L., Schneider, R., Rubin, C., Houser, V., Beebe, K. L., Kortboyer, J. M., Eckland, D. J. A., Cranmer, H., Mori, Y., Kurokawa, N., Komiya, H., Horikoshi, H., Yokoyama, J., Tajima, N., Ikeda, Y., Bakst, A., Hemyari, P., Lönnqvist, F., Owen, S., Vikramadithyan, R. K., Chakrabarti, R., Misra, P., Prem Kumar, M., Sunil Kumar, K. B., Ghosh, A., Rajagopalan, R., Goldstein, B., Katoh, S., Tsuruoka, N., Hata, S., Matsushima, M., Ikemoto, S., Inoue, Y., Edwards, G., Fonseca, V., Biswas, N., Bakris, G., Viberti, G., Rebuck, A. S., Weill, S., Abel, M. G., Klappoth, W., Brodesser, A., Linkeschowa, R., Pushparaj, P., Tan, C. H., Tan, B. K. H., Bahner, A., Parker, J., Waite, G., Lipson, V., Nahar, N., Rokeya, B., Parveen, S., Nur-e-Alam, M., Mosihuzzaman, M., Hansen, A. Kornerup, Lepore°, M., Kurzhals, R., Pampanelli°, S., Fanelli°, C. G., Bolli°, G. B., Ratner, R. E., Hirsch, I. B., Mecca, T. E., Wilson, C. A., Mohideen, P., Mudaliar, S., Deutsch, R., Ciaraldi, T., Armstrong, D., Kim, B., Morrill, B., Sha, X., Henry, R., Meyer, B. H., Scholtz, H. E., van Niekerk, N., Rosenkranz, B., Schoenle, E., Witthaus, Elke, Bradley, Clare, Stewart, John, Barbeau, M., Myers, S., Flora, D., DiMarchi, R., Chance, R., Plum, A., Larsen, P. S., Larsen, U. D., Kristensen, J. B., Jansen, J. A., Olsen, B., Mortensen, H., Hylleberg, B., Jacobsen, L. V., Gall, M.-A., Søgaard, B., Ewing, F. M., Ireland, R. H., Hoogwerf, B., Raskin, P., Jovanovic, L., Leiter, L., Boss, A. H., Bott, U., Ebrahim, S., Hirschberger, S., Leukel, P., Sieber, H. J., McGill, J., Kilo, C., Kamp, N. M., Wutte, A., Le Thai, F., Balarac, N., Allicar, M. P., Cazeneuve, B., Augendre, B., Wise, S. D., Seah, E. S., Koivisto, V., Torlone, E., Del Sindaco, P., Ciofetta, M., Hedman, C., Orre Pettersson, A.-C., Lindström, T., Cernigoi, A. M., Kong, N., Kitchen, M. M., Ryder, R. E. J., Petkova, M., Angelova-Gateva, P., Malone, J., Arora, V., Bue-Valleskey, J., Pein, M., Diebler, F., Roach, P., Gudat, U., Dreyer, M., Hanusch, U., Ristic, S., McLeod, J., Hirschberg, Y., Garreffa, S., Keilson, L., Mather, S., Gagen, K., Chen, W., Dragonas, N., Chuang, L. M., Juang, J. H., Wu, H. P., Chiang, Y. D., Li, K. L., Jorgensen, L. N., Tai, T. Y., Cheatham, W. W., Kennedy, F., Woo, V., Jain, R., Boss, A., Moses, R., Clauson, P., Fischer, T., Björk, S., Østergaard, A., Langendorf, K. W., Hatorp, V., Hasslacher, C., Farrar, N. S., Chambers, N. J., Denyer, G. S., Johnston, G. A. R., Hashiguchi, S., Jönsson, A., Hallengren, B., Rydberg, T., Herbaut, C., Turc, A., Mourand, I., Chevassus, H., Molinier, N., Christensen, A.-B. L., Mathiesen, E. R., Stage, E., Damm, P., Boivin, S., Gross, P., Pennington, M., Harder, T., Kohlhoff, R., Dörner, G., Rohde, W., Plagemann, A., Ferdeghini, M., Murru, S., Maffei, M., Cecchetti, P., Dunne, F., Brydon, P., Smith, T., Proffitt, M., Holder, R., Gee, H., Goulis, D. G., Teoh, T. G., Asatiani, N., Elphick, A., Natsvlishvili, M., Chanturia, T., Shelestova, E., Ramazashvili, M., Hod, M., Cederberg, J., Casi, A. Leunda, Pampfer, S., De Hertogh, R., Hinck, L., Aly, S., Bertie, J., Botta, R. M., Imbergamo, M. P., Impiccichè, M. G., Todaro, B., Greco, D., Ekbom, P., Clausen, P., Feldt-Rasmussen, U., Feldt-Rasmussen, B., Mølsted Pedersen, L., Nørgaard, K., Svenningsen, A., Nielsen, L., Zmudzińska, M., Ziętek, I., Min, Y., Crawford, M. A., Bozzoni, F., Corubolo, C., Borrello, E., Di Biase, N., Spagnolo, S., Hawthorne, G., Sen, D., Bagust, A., Maier, W., Currie, C. J., Sailesh, S., Patel, V., Hayes, D., Cockrill, B., Gatling, W., Budd, S., Mullee, M. A., Savill, A. W., Smithers, M. G., Davies, R. R., Sandford, A., Stutz, L., Vadstrup, S., Simonsen, V., Musaeus, L., Molsing, B., Lyholm, B., Turner, B. C., Jenkins, E., Hejlesen, O. J., Andreassen, S., Hovorka, R., Cavan, D. A., Klinge, A., Strauss, K. W., Guthrie, R., Testa, M., Zimmerman, R., Sandberg, M., Steinfatt, H., Hardenberg, R., Gottsmann, M., König, A., Schmauß, S., Hierl, F. X., Renders, C. M., Valk, G. D., van Eijk, J. Th. M., van der Wal, G., Jermendy, G., Hídvégi, T., Müller, U. A., Junghänel, J., Köhler, S., Köhler, C., Schumann, M., Use, G., de Valk, H. W., Blankestijn, J. G., de Bruin, H. J., Bottomley, J., Gillam, S., Holmes, J., Murphy, M., Madani, S. F., Müller, R., Hunger Dathe, W., Grüßer, M., Roien, D., Hussain, M., Vibe-Petersen, J., Braun, A., Schiel, R., Höfer, A., Leppert, K., Trento, M., Passera, P., Tomalino, M., Bajardi, M., Vaccari, P., Pagnozzi, F., Pomero, F., Molinatti, G. M., Porta, M., Blaauwwiekel, E. E., Hania, M., Scholten-Jaegers, S. M. H. J., Links, T. 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E., Dell’Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Matthäei, S., Pfohl, M., McInerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvári, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Pótó, L., Wagner, L., Mazák, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D’Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A.-S., Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O’Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
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- 1999
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281. European Panel on the Appropriateness of Gastrointestinal Endoscopy (EPAGE): Conclusion and WWW Site
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Vader, J.-P., Froehlich, F., Dubois, R. W., Beglinger, C., Wietlisbach, V., Pittet, V., Ebel, N., Gonvers, J.-J., and Burnand, B.
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- 1999
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282. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release
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Hildebrand, P., Petrig, C., Burckhardt, B., Ketterer, S., Lengsfeld, H., Fleury, A., Hadvary, P., and Beglinger, C.
- Abstract
Background & Aims: The hypothesis that cholecystokinin release requires adequate dietary fat digestion in the small intestine was investigated in 10 healthy volunteers, and the consequences of reduced fat hydrolysis on pancreaticobiliary secretions were assessed. Methods: Fat hydrolysis was inhibited by intraduodenal perfusion of tetrahydrolipstatin, an irreversible lipase inhibitor. An oil emulsion containing 0, 30, 60, or 120 mg tetrahydrolipstatin was perfused. After a 40-minute basal period, a test meal was eaten to stimulate cholecystokinin release and pancreaticobiliary responses. Results: In the control without tetrahydrolipstatin, lipase output increased threefold with meal ingestion and remained doubled for 4 hours. At the ligament of Treitz, free fatty acid concentration averaged 60% of total fatty acids. Increasing doses of tetrahydrolipstatin induced a dose-dependent inhibition of duodenal lipase activity (P < 0.01); 120 mg tetrahydrolipstatin eliminated the postprandial lipase peak activity, free fatty acid levels decreased to <5% of total fatty acids, and plasma cholecystokinin levels were suppressed by 77% (P < 0.01). Amylase and trypsin outputs were reduced by 77% and 59%, respectively, and bilirubin secretion was virtually abolished (P < 0.01). Conclusions: These findings show that tetrahydrolipstatin prevents triglyceride hydrolysis and that plasma cholecystokinin release, gallbladder emptying, and pancreatic enzyme secretion require adequate triglyceride digestion. These data also support the concept of negative feedback regulation of cholecystokinin secretion. GASTROENTEROLOGY 1998;114:123-129
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- 1998
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283. The Ileocecal Reservoir for Rectal Replacement in Complicated Radiation Proctitis
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Fluee, M. O. Von, Degen, L. P., Beglinger, C., and Harder, F. H.
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- 1996
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284. Comparison of the Effects of the M1Receptor Antagonist Telenzepine and the CCKReceptor Antagonist Loxiglumide on the Pancreatic Secretory Response to Intraduodenal Tryptophan in Dogs
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Teyssen, S., Niebergall-Roth, E., Rausch, A., Beglinger, C., Riepl, R. L., Chari, S., and Singer, M. V.
- Abstract
In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses (20.25 to 81.0 nmol/kg/h) of the muscarinic M1-receptor antagonist telenzepine, the cholecystokinin (CCK) antagonist loxiglumide (2.5 to 10.0 mg/kg/h) and several combinations of both drugs on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37–10.0 mmol/h) given against a background of secretin (20.5 pmol/kg/h i.v.). Except for 20.25 nmol/kg/h telenzepine, all tested doses of telen-zepine and/or loxiglumide decreased the 180-min integrated bicarbonate response to tryptophan by 55 to 119. Except of 20.25 nmol/kg/h telenzepine and/or 2.5 mg/kg/h loxiglumide, all tested doses of telenzepine and/or loxiglumide inhibited the tryptophan stimulated integrated pancreatic protein response by 54 to 88. While telenzepine mainly inhibited the bicarbonate and protein response to the lower loads of tryptophan (0.37–1.1 mmol/h), loxiglumide decreased the response to all loads of tryptophan. The inhibition evoked by the combinations of telenzepine and loxiglumide was not significantly greater than that by single infusion of either drug. The CCK plasma levels basally and in response to tryptophan were not significantly altered by telenzepine and/or loxiglumide. These findings indicate that (1) both enteropancreatic cholinergic reflexes and the hormone CCK are mediators of the protein response to intraduodenal tryptophan, (2) enteropancreatic cholinergic reflexes are probably the dominant mediators of the response to low amounts of tryptophan, whereas CCK is the major mediator of the response to high loads of tryptophan, (3) the two mediators seem to act independently of each other, and (4) the release of CCK by intestinal tryptophan is not influenced by telenzepine or loxiglumide.
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- 1996
285. LowDose Octreotide Treatment Is Not Effective in Patients with Advanced Pancreatic Cancer
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Friess, H., Buchler, M., Beglinger, C., Weber, A., Kunz, J., Fritsch, K., Dennler, H. J., and Beger, H. G.
- Abstract
Octreotide (SMS 201–999, a long-acting somatostatin analogue, has been shown to decelerate growth of human pancreatic cancer in vitro and in vivo. We analyzed the efficacy of octreotide treatment in 22 patients (14 men, 8 women) with histologically verified ductal pancreatic cancer. All patients had advanced tumor stages (stage 111: 13 patients; stage IV: 9 patients). Octreotide was given by self-administered subcutaneous injection (3 × 100 kg/day). When there was evidence of tumor progression, the dose of octreotide was increased to 3 × 200 μg/day. A monthly follow-up, including clinical status, CT scan or ultrasonography, and tumor marker carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19–9 determination was carried out. There were no severe side effects apart from slight burning sensation at the injection site. No partial or complete remission was seen. Eighteen patients showed tumor progression with a median survival time of 17 weeks (range 3–42 weeks). In three patients a “no change” evaluation with a median survival time of 46 weeks (range 40–68 weeks) was registered. In these three patients the serum tumor markers CA 19–9 and CEA did not show an increase to more than twice the baseline value during this time. One patient discontinued the octreotide treatment because of tumor progression. The results of the analysis indicate that lowdose octreotide treatment is not effective in patients suffering from advanced tumor stages of pancreatic cancer.
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- 1993
286. Physiological role of cholecystokinin on postprandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor antagonist loxiglumide
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Fried, M., Schwizer, W., Beglinger, C., Keller, U., Jansen, J., and Lamers, C.
- Abstract
Cholecystokinin was previously proposed to play an important role in the regulation of postprandial insulin secretion either indirectly, by inhibiting gastric meal emptying, or directly, by acting as an incretin promoting the release of insulin. The aim of this investigation was therefore to clarify the role of endogenous cholecystokinin in the regulation of insulin release and gastric emptying applying the highly potent and specific cholecystokinin receptor antagonist loxiglumide. Five healthy volunteers were examined after an overnight fast. Gastric meal emptying was measured by the double indicator technique using a multiple lumen tube in the duodenum and 99mTc-diethylenetriamine pentaacetate as a meal marker and polyethylene glycol 4000 as a duodenal perfusion marker. Postprandial insulin, C-peptide, cholecystokinin and glucose levels were measured after ingestion of two isocaloric meals of a) Ensure (containing fat, protein and glucose), and b) a pure glucose meal (1.11 mol/l). The meals were given either with an intravenous infusion of loxiglumide (22 μmol·kg−1·h−1) or placebo. The infusion of loxiglumide markedly accelerated the gastric emptying of the mixed meal (area under curve, 5576±352 min vs 3498±109 min; p<0.001) and the pure glucose meal (area under curve 5662±537 min vs 3551±534 min; p<0.05). Simultaneously, loxiglumide induced a more rapid rise in postprandial insulin levels after both meals resulting in significantly higher (p<0.05) insulin levels during the first postprandial hour, but similar insulin levels in the second postprandial hour. Accordingly, we found a close correlation between meal emptying and insulin release (r=0.748, p<0.01). Integrated insulin and C-peptide levels for the whole 2-h experimental period tended to be higher during loxiglumide infusion, but the difference did not reach statistical significance. Similar plasma glucose levels at all time periods were observed with and without loxiglumide infusion. Higher cholecystokinin levels were measured during loxiglumide infusion after the mixed (p<0.01) and the pure dextrose (p<0.05) meals. We conclude that postprandially released cholecystokinin exerts an important role in the regulation of gastric meal emptying and consecutively the postprandial pattern of insulin release. In contrast, no evidence was found for an insulinotropic role for cholecystokinin in man.
- Published
- 1991
- Full Text
- View/download PDF
287. Neue technische Entwicklungen
- Author
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A. Beham, B. C. Manegold, C. J. Cahill, R. Bähr, G. Hauck, F. Schier, C. Ackermann, A.-K. Eckstein, Beglinger C, R. Elfeldt, W. Hartel, F. G. Krammling, J. C. Patel, Rothenbühler Jm, B. Meier, K. H. Fuchs, Hans Troidl, B. Zederfeldt, K. H. Vestweber, Marx A, J. Jeekel, Ernst Eypasch, H. F. Kienzle, Ch. Sebening, J. A. Gruwez, A. Kohlstetter, Siegfried Walgenbach, W. Stenzl, U. Mechtersheimer, L. Kronberger, W. Wahl, M. Betzler, R. Kirchner, C. Mick, H. Schaube, T. R. DeMeester, M. Jung, J. Radomsky, Th. Junginger, H. Hamelmann, S. Uranüs, F. Harder, and J. Waldschmidt
- Abstract
Vom 1. 9. 1985 bis zum 31. 12. 1988 wurden 87 Anastomosen gefertigt; 59 wegen Sigmadivertikultitis, 21 bei Morbus Crohn/Colitis ulcerosa, 4 nach Radiatio und 3 nach ischamischer Kolitis. 47 manuelle Anastomosen, vorwiegend im rektosigmoidalen Ubergang stehen 40 Stapleranastomosen, besonders im oberen und mittleren Rektumdrittel gegenuber. Nach Klammernaht setzte die Stuhltatigkeit fruher ein, die Infusionsdauer war kurzer. Ein symptomatischer Nahtbruch entstand nach Anwendung des EEA-Premiumgerates. Kein Patient verstarb. Narbige Anastomosenstenosen entwickelten sich nicht. Besonders im oberen und mittleren Rektum stellen die Stapler eine wichtige Erganzung der chirurgischen Technik dar.
- Published
- 1989
288. Secretin and pancreatic enzyme secretion.
- Author
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Beglinger, C, Köhler, E, Whitehouse, I, and Gyr, K
- Published
- 1985
289. Screening for tuberculosis infection before the initiation of an anti-TNF-alpha therapy
- Author
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Beglinger C, Dudler J, Mottet C, Laurent P Nicod, Seibold F, Pm, Villiger, and Jp, Zellweger
- Subjects
Time Factors ,Immune Reconstitution Inflammatory Syndrome ,Tumor Necrosis Factor-alpha ,Mandatory Testing ,Antitubercular Agents ,Antibodies, Monoclonal ,Humans ,Antibodies, Monoclonal/therapeutic use ,Antitubercular Agents/therapeutic use ,Bacterial Infections/diagnosis ,Immune Reconstitution Inflammatory Syndrome/chemically induced ,Immune Reconstitution Inflammatory Syndrome/prevention & control ,Sensitivity and Specificity ,Skin Tests ,Tuberculosis, Pulmonary/diagnosis ,Tuberculosis, Pulmonary/drug therapy ,Tuberculosis, Pulmonary/prevention & control ,Tumor Necrosis Factor-alpha/antagonists & inhibitors ,Bacterial Infections ,Tuberculosis, Pulmonary
290. PAN-EUROPEAN REGISTRY ON H-PYLORI MANAGEMENT (HP-EUREG): FIRST-LINE TREATMENTS AND INTERIM ANALYSIS OF 11 272 PATIENTS
- Author
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Mcnicholl, A. G., Gasbarrini, A., Tepes, B., Bordin, D. S., Lerang, F., Leja, M., Rokkas, T., Vaira, D., Shvets, O., Kupcinskas, L., Perez-Aisa, A., Axon, T., Buzas, G. M., Castro, M., Simsek, I., Katicic, M., Machado, J. C., Lamy, V., Przytulski, K., Rodrigo, L., Boyanova, L., Bytzer, P., Beglinger, C., Cappelle, L. G., Goldis, A., Veijola, L., Vujasinovic, M., Luis Bujanda, Molina-Infante, J., Caldas, M., Ramas, M., Donday, M. G., Megraud, F., O Morain, C., and Gisbert, J. P.
291. PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): BACTERIAL RESISTANCE
- Author
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Mcnicholl, A. G., Gasbarrini, A., Tepes, B., Bordin, D. S., Lerang, F., Leja, M., Rokkas, T., Vaira, D., Shvets, O., Kupcinskas, L., Perez-Aisa, A., Axon, T., Buzas, G. M., Castro, M., Simsek, I., Katicic, M., Machado, J. C., Lamy, V., Przytulski, K., Rodrigo, L., Boyanova, L., Bytzer, P., Beglinger, C., Cappelle, L. G., Goldis, A., Veijola, L., Vujasinovic, M., Luis Bujanda, Molina-Infante, J., Caldas, M., Ramas, M., Donday, M. G., Megraud, F., O Morain, C., and Gisbert, J. P.
292. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
- Author
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. 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V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. 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A., Reljanovic, M., Barada, A., Milicevic, Z., Tack, Cees J., Croatian Study Group for Diabetic Amyotrophy, Goldstein, David S., Huysen, C., Stevens, M. J., Cao, X., Sundkvist, G., Dahlin, L-B, Eriksson, K-F, Rosen, I., Lattimer, S. A., Sima, A. A. F., Sullivan, K., Shaw, J. E., Courten, M. P., Zimmet, P. Z., Gourdy, P., Ruidavets, J. B., Arveiler, D., Amouyel, Ph, Bingham, A., Tauber, J. P., Lam, K. S. L., Wat, N. M. S., Lam, T. H., Janus, E. D., Pablos, P., Rodriguez, F., Martinez, J., Sanchez, V., Santana, C., Garcia, I., Macias, A., Levin, K., Hother-Nielsen, O., Henriksen, J. E., Beck-Nielsen, H., Brechtel, K., Machann, J., Koch, M., Nielsen, M., Loblein, K., Becker, R., Denignger, M., Renn, W., Machicao, F., Claussen, C. 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F., Cros, G., Bringer, J., Del Aguila, L. F., Krishnan, R. K., Farrell, P. A., Ulbrecht, J., Correll, P. H., Kirwan, J. P., Mei, J., Rahn-Landstrom, T., Brindley, D., Manganiello, V., Degerman, E., Ziv, E., Shafrir, E., Kaiman, R., Galer, S., Bar-On, H., Gero, L., Foldes, K., Janssen, J., Jaray, J., Perner, F., Haap, M., Houdali, B., Schmit, M. B., Dietze, G. J., Perrini, S., Natalicchio, A., Montrone, C., Robertis, O., Pergola, G., Strack, V., Kellerer, M., Kausch, C., Condorelli, G., Beguinot, F., Haring, H-U, Song, X. M., Chibalin, A. V., Ryder, J. W., Jiang, X. J., Alessi, D. R., Hennige, A. M., Metzinger, E., Seipke, G., Trub, T., Hey, A., Sorensen, A. R., Schaffer, L., Drejer, K., Kurtzhals, P., Hansen, B. F., Matozaki, T., Noguchi, T., Yamao, T., Takada, T., Ochi, F., Takeda, H., Inagaki, K., Hosoka, T., Kasuga, M., Schurt, M., Meier, M., Drenckhan, M., Meyer, M., Aries, S. P., Klein, H. H., Telting, D., Zon, G. C. M., Dorrestijn, J., Maassen, J. A., Clapham, J. C., Holder, J. 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U., Rave, Klaus, Heise, Tim, Clauson, Per, Hirschberger, Sabine, Heinemann, Lutz, Claret, M., Nadal, B., Truc, A., Rossi, L., Hildebrand, P., Ketterer, S., Beglinger, C., Keller, U., Gyr, K., Parvin, S., Overkamp, D., Vayreda, M., Gonzalez-Huix, F., G-Huix, F., Zavaroni, I., Gasparini, P., Massironi, P., Zuccarelli, A., Delsignore, R., Reaven, G. M., Sheu, W. H. H., Lee, W. J., Chen, Y-T, Iraklianou, S., Tournis, S., Volonakis, I., Spylopoulou, M., Bilianou, E., Melidonis, A., Foussas, S., Guler, Serdar, Cakir, Bekir, Demi Rbas, Berrin, Gursoy, Gul, Serter, Rustu, Aral, Yalcin, Morton, G., Lee, S., Fahey, R., Silva, A., Cai, X. J., Buckingham, R. E., Arch, J. R. S., Wilson, S., Clausen, J. T., Kristensen, P., Nielsen, P. F., Wulff, B. S., Thim, L., Holness, M. J., Sugden, M. C., Fryer, L. G. D., Munns, M. 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Sorhede, Svensson, H., Ahnen, B., Holm, C., Phillips, C., Madigan, C., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Cabezas, M. Castro, Oostrom, A. J. H. H. M., Erkelens, D. W., Summers, L. K. M., Fielding, B. A., Ilic, V., Clark, M. L., Frayn, K. N., Pietzsch, J., Julius, U., Nitzsche, S., Fischer, S., Lindgren, C., Amrot-Fors, L., Hoffmann, M. M., Luft, D., Schmulling, R-M, D Adamo, M., Leonetti, F., Paoloni, A., Ribaudo, M. C., Basso, M. S., Elmore, U., Restuccia, A., Sbraccia, P., Emilsson, V., O Dowd, J., Heyman, R., Cawthorne, M. A., Pelikanova, T., Kazdova, L., Zak, A., Chvojkova, S., Ozer, E. M., Kadioglu, P., Korugan, U., Hatemi, H., Rivellese, A. A., Dullaart, R. P. F., Riemens, S. C., Sluiter, W. J., Tol, A., Farnier, M., Megnien, S., Turpin, G., Cerivastatin Combination Therapy Study Group, Stulp, B. K., Brambilla, P., Brunelli, A., Riva, M. C., Manzoni, P., Poli, S., Riboni, S., Stolk, R. P., Meijer, R., Wink, O., Zelissen, P. M. J., Gils, A. P. G., Grobbee, D. 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293. Fatal invasive pulmonary aspergillosis associated with adalimumab therapy
- Author
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Manz, M, Beglinger, C, and Vavricka, S R
- Subjects
3. Good health
294. Helicobacter pylori Colonization in Infants and Young Children is Not Necessarily Associated with Diarrhoea
- Author
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Rahman, M. M., Mahalanabis, D., Sarker, S. A., Bardhan, P. K., Alvarez, J. O., Hildebrand, P., Beglinger, C., Gyr, Klaus, Rahman, M. M., Mahalanabis, D., Sarker, S. A., Bardhan, P. K., Alvarez, J. O., Hildebrand, P., Beglinger, C., and Gyr, Klaus
- Abstract
A cohort of 151 infants and young children aged 1-23 months from a poor peri-urban community of Bangladesh was studied to determine the relationship between Helicobacter pylori colonization and morbidity due to diarrhoea. A 13C urea breath test was performed to detect the presence of H. pylori.Children were followed up at home every alternate day for 6 months and diarrhoeal morbidity datawere collected. Diarrhoeal morbidity was compared between H. pylori-positive and H. pylori-negative children. Sixty-eight (45 per cent) children were H. pylori positive and 83 (55 per cent) were H. pylori negative. During the first 1-month period following the breath test, three (4.4 per cent) H. pylori-positive and four (4.8 per cent) H. pylori-negative children had diarrhoea. Thirty-two (47 per cent) of the children in the positive group and 43 (52 per cent) in the negative group had one or more episodesof diarrhoea during the 6-month follow-up period. Median number of diarrhoeal episodes was 1.0(range 1.0-4.0) in the H. pylori-positive children and 2.0 (range 1.0-5.0) in the H. pylori-negativechildren (p = 0.19). No significant difference was observed in the cumulative days with diarrhoea.The results of this study suggest that H. pylori colonization is not associated with diarrhoealmorbidity in infants and young children
295. Acid-Stimulated Ductular Bile Flow
- Author
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Beglinger, C., primary, Whitehouse, I., additional, Fried, M., additional, and Gyr, K., additional
- Published
- 1984
- Full Text
- View/download PDF
296. Pancreatic polypeptide inhibits exocrine pancreatic responses to six stimulants
- Author
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Beglinger, C., primary, Taylor, I. L., additional, Grossman, M. I., additional, and Solomon, T. E., additional
- Published
- 1984
- Full Text
- View/download PDF
297. Interaction between stimulants of exocrine pancreatic secretion in dogs
- Author
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Beglinger, C., primary, Grossman, M. I., additional, and Solomon, T. E., additional
- Published
- 1984
- Full Text
- View/download PDF
298. The release of pancreatic polypeptide by CCK-octapeptide and some analogues in the dog
- Author
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Meyer, F.D., primary, Gyr, K., additional, Hacki, W.H., additional, Beglinger, C., additional, Jeker, L., additional, Varga, L., additional, Kayasseh, L., additional, Gillessen, D., additional, and Stalder, G.A., additional
- Published
- 1981
- Full Text
- View/download PDF
299. Cephalic phase of pancreatic secretion
- Author
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Beglinger, C., primary, Gyr, K., additional, Fried, M., additional, and Whitehouse, I., additional
- Published
- 1985
- Full Text
- View/download PDF
300. Bioactivity of cholecystokinin analogues: CCK-8 is not more potent than CCK-33
- Author
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Solomon, T. E., primary, Yamada, T., additional, Elashoff, J., additional, Wood, J., additional, and Beglinger, C., additional
- Published
- 1984
- Full Text
- View/download PDF
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