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1,644 results on '"Barnes K."'

252. The Gene Encoding SET and MYND domain containing 3 (SMYD3) is Associated with Asthma in Populations of African Descent

Author

Vergara, C.I., primary, Mathias, R.A., additional, Rafaels, N., additional, Hand, T., additional, Campbell, M., additional, Faruque, M., additional, Dunston, G., additional, Beaty, T., additional, Oliveira, R., additional, Ponte, E., additional, Carvalho, E., additional, Araujo, M.I., additional, Watson, H., additional, Caraballo, L., additional, Knight-Madden, J., additional, and Barnes, K., additional

Published
2010
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256. BOARD-INVITED REVIEW: The biology and regulation of preadipocytes and adipocytes in meat animals1,2

Author

Hausman, G. J., primary, Dodson, M. V., additional, Ajuwon, K., additional, Azain, M., additional, Barnes, K. M., additional, Guan, L. L., additional, Jiang, Z., additional, Poulos, S. P., additional, Sainz, R. D., additional, Smith, S., additional, Spurlock, M., additional, Novakofski, J., additional, Fernyhough, M. E., additional, and Bergen, W. G., additional

Published
2009
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257. Leptin receptor polymorphisms and lung function decline in COPD

Author

Hansel, N. N., primary, Gao, L., additional, Rafaels, N. M., additional, Mathias, R. A., additional, Neptune, E. R., additional, Tankersley, C., additional, Grant, A. V., additional, Connett, J., additional, Beaty, T. H., additional, Wise, R. A., additional, and Barnes, K. C., additional

Published
2009
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260. QED's 'PC Plus': Training Program Introduces Novices to PC Fundamentals

Author

Barnes, K.

Subjects
User training, PC Plus -- Evaluation, User training, Computer-assisted instruction
Abstract

Since there is no shortage of PC introductory training programs on the market, PC Plus, from QED Corp. of Wellesley, Mass., is a bit of a latecomer. This product will, […]

Published
1985

261. 'Speed Reading': Despite Installation Problems, Software Quickens Reading Pace

Author

Barnes, K.

Subjects
Speed Reading The Computer Course -- Evaluation, Courseware -- Evaluation -- Product/service Evaluations, Computer-assisted instruction, Evaluation
Abstract

We live in an information age, and the printed word is a prime source of that information. The ability to determine what to read and then read the chosen material […]

Published
1985

262. Software Support Dilemma: Sources Differ on Service Mandate

Author

Barnes, K.

Subjects
Support services, User need, Direct market channel, Mainframe computer, Software quality, Customer service, Cost reduction, Retail/reseller channel, End user, Distribution channels, Software, Computer software industry, Cost control, End users, Mainframe computers, Customer service
Abstract

Nearly every microcomputer user can recount at least one story of trial and tribulation in getting product support after purchasing software. Veterans of these efforts complain of frustration due to […]

Published
1985

263. Call for Experts

Author

Barnes, K. and Barnes, H.

Subjects
Direct market channel, Software quality, Retail/reseller channel, Distribution channels, Software, Consultants, Evaluation
Abstract

Despite the fact that the purchase and use of personal computers represents a major corporate investment, many business users prefer to reman unfamiliar with the ins and outs of computing […]

Published
1984

264. CBT Products Are Being Developed to Train Managers

Author

Barnes, K.

Subjects
Courseware, Computer-assisted instruction, Management
Abstract

A popular misconception about computer-based training is that it is only used to teach people about computer systems. Actually, computer-based training (CBT) is also used in management training. Management training […]

Published
1984

265. Computer Training Groups, Ccnferences Available Nationwide

Author

Barnes, K.

Subjects
Computer education, Software/hardware leasing, Microcomputer industry, Computer industry, Computers, Computer industry, Education, Continuing education
Abstract

There are many professional groups and conferences addressing the interests of trainers and even more serving computer professionals in general. But where do people who are interested in computers and […]

Published
1984

266. Buyer Beware

Author

Barnes, K.

Subjects
Software quality, Computer science literature, Software, Software selection, Computer literature
Abstract

Personal-computer publications are notorious for their thickness and weight, and their size is directly attributable to the amount of advertising they carry. All that advertising has value. Certainly the publishers […]

Published
1984

268. Interactive Videotape Stops the Gap Between Computers, Videodisks

Author

Barnes, K.

Subjects
Videodiscs
Abstract

Videodisks coupled with computers have received attention. However, many corporations are shying away from them, considering the videodisk an immature technology. As one corporate manager put it, 'Why should I […]

Published
1984

269. 'Pascal Tutor': Sophisticated Users Are Trained Quickly in Spite of Tedium

Author

Barnes, K.

Subjects
Programming language, Educational/training software, Pascal Tutor -- Evaluation, PASCAL, Programming languages -- Evaluation -- Product/service Evaluations, Computer-assisted instruction, Educational software -- Evaluation -- Product/service Evaluations
Abstract

Now you can learn the programming language Pascal by computer. Pascal Tutor, by Gamma Software, is composed of a floppy disk, which holds the course along with program exaples, and […]

Published
1984

270. 'dBase II' Tutorial

Author

Barnes, K.

Subjects
DBMS, Educational/training software, DBMS utility, User training, Beginning Instructions dBase II -- Evaluation, User training, Database management systems -- Evaluation -- Product/service Evaluations, Evaluation, Educational software -- Evaluation -- Product/service Evaluations
Abstract

Beginning Instructions for dBASE II' is a self-paced tutorial distributed by Data Processing Educational Corporation (DPEC). The course consists of two 'Instant Tutor!' floppy disks and a reference guide. The […]

Published
1984

271. CBT Authoring Tools

Author

Barnes, K.

Subjects
Computer-assisted instruction
Abstract

A major southwestern bank had an ongoing need to retrain tellers. Since the training would involve a high number of persons in distributed areas, and since tellers are familiar with […]

Published
1984

277. The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients.

Author

Kredo, T., Mauff, K., Workman, L., Van der Walt, J. S., Wiesner, L., Smith, P. J., Maartens, G., Cohen, K., and Barnes, K. I.

Subjects
DRUG interactions, ANTIRETROVIRAL agents, HIV-positive persons, LOPINAVIR-ritonavir, HIV infections, THERAPEUTICS, ANTIMALARIALS, CLINICAL trials, COMPARATIVE studies, ETHANOLAMINES, HETEROCYCLIC compounds, HIV, HYDROCARBONS, RESEARCH methodology, MEDICAL cooperation, RESEARCH, EVALUATION research, ANTI-HIV agents, RITONAVIR
Abstract

Background: Artemether-lumefantrine is currently the most widely recommended treatment of uncomplicated malaria. Lopinavir-based antiretroviral therapy is the commonly recommended second-line HIV treatment. Artemether and lumefantrine are metabolised by cytochrome P450 isoenzyme CYP3A4, which lopinavir/ritonavir inhibits, potentially causing clinically important drug-drug interactions.Methods: An adaptive, parallel-design safety and pharmacokinetic study was conducted in HIV-infected (malaria-negative) patients: antiretroviral-naïve and those stable on lopinavir/ritonavir-based antiretrovirals. Both groups received the recommended six-dose artemether-lumefantrine treatment. The primary outcome was day-7 lumefantrine concentrations, as these correlate with antimalarial efficacy. Adverse events were solicited throughout the study, recording the onset, duration, severity, and relationship to artemether-lumefantrine.Results: We enrolled 34 patients. Median day-7 lumefantrine concentrations were almost 10-fold higher in the lopinavir than the antiretroviral-naïve group [3170 versus 336 ng/mL; p = 0.0001], with AUC(0-inf) and Cmax increased five-fold [2478 versus 445 μg.h/mL; p = 0.0001], and three-fold [28.2 versus 8.8 μg/mL; p < 0.0001], respectively. Lumefantrine Cmax, and AUC(0-inf) increased significantly with mg/kg dose in the lopinavir, but not the antiretroviral-naïve group. While artemether exposure was similar between groups, Cmax and AUC(0-8h) of its active metabolite dihydroartemisinin were initially two-fold higher in the lopinavir group [p = 0.004 and p = 0.0013, respectively]. However, this difference was no longer apparent after the last artemether-lumefantrine dose. Within 21 days of starting artemether-lumefantrine there were similar numbers of treatment emergent adverse events (42 vs. 35) and adverse reactions (12 vs. 15, p = 0.21) in the lopinavir and antiretroviral-naïve groups, respectively. There were no serious adverse events and no difference in electrocardiographic QTcF- and PR-intervals, at the predicted lumefantrine Tmax.Conclusion: Despite substantially higher lumefantrine exposure, intensive monitoring in our relatively small study raised no safety concerns in HIV-infected patients stable on lopinavir-based antiretroviral therapy given the recommended artemether-lumefantrine dosage. Increased day-7 lumefantrine concentrations have been shown previously to reduce the risk of malaria treatment failure, but further evidence in adult patients co-infected with malaria and HIV is needed to assess the artemether-lumefantrine risk : benefit profile in this vulnerable population fully. Our antiretroviral-naïve patients confirmed previous findings that lumefantrine absorption is almost saturated at currently recommended doses, but this dose-limited absorption was overcome in the lopinavir group.Trial Registration: Clinical Trial Registration number NCT00869700. Registered on clinicaltrials.gov 25 March 2009. [ABSTRACT FROM AUTHOR]

Published
2016
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282. N-halamine biocidal coatings

Author

Liang, J., primary, Wu, R., additional, Wang, J.-W., additional, Barnes, K., additional, Worley, S. D., additional, Cho, U., additional, Lee, J., additional, Broughton, R. M., additional, and Huang, T.-S., additional

Published
2006
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285. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families

Author

Barnes, K C, primary, Grant, A V, additional, Baltadzhieva, D, additional, Zhang, S, additional, Berg, T, additional, Shao, L, additional, Zambelli-Weiner, A, additional, Anderson, W, additional, Nelsen, A, additional, Pillai, S, additional, Yarnall, D P, additional, Dienger, K, additional, Ingersoll, R G, additional, Scott, A F, additional, Fallin, M D, additional, Mathias, R A, additional, Beaty, T H, additional, Garcia, J G N, additional, and Wills-Karp, M, additional

Published
2005
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286. Injury

Author

Khan, Munir, primary, Waseem, M., additional, and Barnes, K., additional

Published
2005
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