212,488 results on '"An, Clemens"'
Search Results
252. Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial
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Schuler, Martin, Cuppens, Kristof, Plönes, Till, Wiesweg, Marcel, Du Pont, Bert, Hegedus, Balazs, Köster, Johannes, Mairinger, Fabian, Darwiche, Kaid, Paschen, Annette, Maes, Brigitte, Vanbockrijck, Michel, Lähnemann, David, Zhao, Fang, Hautzel, Hubertus, Theegarten, Dirk, Hartemink, Koen, Reis, Henning, Baas, Paul, Schramm, Alexander, and Aigner, Clemens
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- 2024
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253. Two-dimensional few-atom noble gas clusters in a graphene sandwich
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Längle, Manuel, Mizohata, Kenichiro, Mangler, Clemens, Trentino, Alberto, Mustonen, Kimmo, Åhlgren, E. Harriet, and Kotakoski, Jani
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- 2024
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254. Therapie des kolorektalen Karzinoms - Neues und Bewährtes
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Wirth, Ulrich, Holch, Julian, Brandlhuber, Martina, Walter, Franziska, Gießen-Jung, Clemens, Angele, Martin, Werner, Jens, and Kühn, Florian
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- 2024
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255. Ethnic minorities treated with new-generation drug-eluting coronary stents in two European randomised clinical trials
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Ploumen, Eline H., Semedo, Edimir, Doggen, Carine J. M., Schotborgh, Carl E., Anthonio, Rutger L., Danse, Peter W., Benit, Edouard, Aminian, Adel, Stoel, Martin G., Hartmann, Marc, van Houwelingen, K. Gert, Scholte, Martijn, Roguin, Ariel, Linssen, Gerard C. M., Zocca, Paolo, and von Birgelen, Clemens
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- 2024
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256. Anforderungen an eine Ausbildung zum:zur diplomierten Notfallsanitäter:in: Weiterentwicklungen im österreichischen Rettungswesen
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Trimmel, Helmut, Zahorka, Florian, Kaltenberger, Clemens, Fohringer, Christian, and Dünser, Martin
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- 2024
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257. Predictors of 30-day recurrent emergency department visits for hyperglycemia in patients with types 1 and 2 diabetes: a population-based cohort study
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Yan, Justin W., Vujcic, Branka, Le, Britney N., Van Aarsen, Kristine, Chen, Tom, Halane, Fardowsa, and Clemens, Kristin K.
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- 2024
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258. Additional Guidance on the Use of the PRESERFLO™ MicroShunt in the Treatment of Glaucoma: Insights from a Second Delphi Consensus Panel
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Khawaja, Anthony P., Abegão Pinto, Luís, Stalmans, Ingeborg, Aptel, Florent, Barkander, Anna, Barton, Keith, Beckers, Henny, Iliev, Milko, Klink, Thomas, Marchini, Giorgio, Martínez de la Casa, Jose, Pillunat, Karin R., Simonsen, Jan H., and Vass, Clemens
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- 2024
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259. Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management
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Kümpfel, Tania, Giglhuber, Katrin, Aktas, Orhan, Ayzenberg, Ilya, Bellmann-Strobl, Judith, Häußler, Vivien, Havla, Joachim, Hellwig, Kerstin, Hümmert, Martin W., Jarius, Sven, Kleiter, Ingo, Klotz, Luisa, Krumbholz, Markus, Paul, Friedemann, Ringelstein, Marius, Ruprecht, Klemens, Senel, Makbule, Stellmann, Jan-Patrick, Bergh, Florian Then, Trebst, Corinna, Tumani, Hayrettin, Warnke, Clemens, Wildemann, Brigitte, and Berthele, Achim
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- 2024
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260. Persons with multiple sclerosis older than 55 years: an analysis from the German MS registry
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Goereci, Yasemin, Ellenberger, David, Rommer, Paulus, Dunkl, Veronika, Golla, Heidrun, Zettl, Uwe, Stahmann, Alexander, and Warnke, Clemens
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- 2024
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261. Characteristics and demography of low energy fall injuries in patients > 60 years of age: a population-based analysis over a decade with focus on undertriage
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Aarsland, Martine A., Weber, Clemens, Enoksen, Cathrine H., Dalen, Ingvild, Tjosevik, Kjell Egil, Oord, Pieter, and Thorsen, Kenneth
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- 2024
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262. Survey in radiation oncology departments in Germany, Austria, and Switzerland: state of digitalization by 2023
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Janssen, Stefan, El Shafie, Rami A., Grohmann, Maximilian, Knippen, Stefan, Putora, Paul M., Beck, Marcus, Baehr, Andrea, Clemens, Patrick, Stefanowicz, Sarah, Rades, Dirk, Becker, Jan-Niklas, and Fahlbusch, Fabian B.
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- 2024
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263. MR 4D flow–derived left atrial acceleration factor for differentiating advanced left ventricular diastolic dysfunction
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Reiter, Clemens, Reiter, Ursula, Kräuter, Corina, Kolesnik, Ewald, Scherr, Daniel, Schmidt, Albrecht, Fuchsjäger, Michael, and Reiter, Gert
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- 2024
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264. Impaired immune responses and prolonged viral replication in lung allograft recipients infected with SARS-CoV-2 in the early phase after transplantation
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Glueck, Olaf M., Liang, Xiaoling, Badell, Irina, Wratil, Paul R., Graf, Alexander, Krebs, Stefan, Blum, Helmut, Hellmuth, Johannes C., Scherer, Clemens, Hollaus, Alexandra, Spaeth, Patricia M., Karakoc, Burak, Fuchs, Thimo, Zimmermann, Julia, Kauke, Teresa, Moosmann, Andreas, Keppler, Oliver T., Schneider, Christian, and Muenchhoff, Maximilian
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- 2024
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265. Why we need to abandon fixed cutoffs for goodness-of-fit indices: An extensive simulation and possible solutions
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Groskurth, Katharina, Bluemke, Matthias, and Lechner, Clemens M.
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- 2024
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266. Magnetointerferometry of multiterminal Josephson junctions
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Mélin, Régis, Winkelmann, Clemens B., and Danneau, Romain
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Condensed Matter - Superconductivity ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We report a theoretical study of multiterminal Josephson junctions under the influence of a magnetic field $B$. We consider a ballistic rectangular two-dimensional metal $N_0$ connected by the edges to the left, right, top and bottom superconductors $S_L$, $S_R$, $S_T$ and $S_B$, respectively. We numerically calculate in the large-gap approximation the critical current $I_c$ versus $B$ between the left and right $S_L$ and $S_R$ for various aspect ratios, with the top and bottom $S_T$ and $S_B$ playing the role of superconducting mirrors. We find the critical current $I_c$ to be enhanced by orders of magnitude, especially at long distance, due to the phase rigidity provided by the mirrors. We obtain superconducting quantum interference device-like magnetic oscillations. With symmetric couplings, the self-consistent superconducting phase variables of the top and bottom mirrors take the values $0$ or $\pi$, as for emerging Ising degrees of freedom. We propose a simple effective Josephson junction circuit model that is compatible with these microscopic numerical calculations. From the $I_c(B)$ patterns we infer where the supercurrent flows in various device geometries. In particular in the elongated geometry, we show that the supercurrent flows between all pairs of contacts, which allows exploring the full phase space of the relevant phase differences., Comment: 15 pages, 6 figures, minor modifications
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- 2023
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267. Discovering Effective Policies for Land-Use Planning with Neuroevolution
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Miikkulainen, Risto, Francon, Olivier, Young, Daniel, Meyerson, Elliot, Schwingshackl, Clemens, Bieker, Jacob, Cunha, Hugo, and Hodjat, Babak
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Computer Science - Neural and Evolutionary Computing ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
How areas of land are allocated for different uses, such as forests, urban areas, and agriculture, has a large effect on the terrestrial carbon balance, and therefore climate change. Based on available historical data on land-use changes and a simulation of the associated carbon emissions and removals, a surrogate model can be learned that makes it possible to evaluate the different options available to decision-makers efficiently. An evolutionary search process can then be used to discover effective land-use policies for specific locations. Such a system was built on the Project Resilience platform and evaluated with the Land-Use Harmonization dataset LUH2 and the bookkeeping model BLUE. It generates Pareto fronts that trade off carbon impact and amount of land-use change customized to different locations, thus providing a potentially useful tool for land-use planning.
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- 2023
268. Fluctuation-induced Forces on Nanospheres in External Fields
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Jakubec, Clemens, Solano, Pablo, Delić, Uroš, and Sinha, Kanu
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Quantum Physics - Abstract
We analyze the radiative forces between two dielectric nanospheres mediated via the quantum and thermal fluctuations of the electromagnetic field in the presence of an external drive. We generalize the scattering theory description of fluctuation forces to include external quantum fields, allowing them to be in an arbitrary quantum state. The known trapping and optical binding potentials are recovered for an external coherent state. We demonstrate that an external squeezed vacuum state creates similar potentials to a laser, despite its zero average intensity. Moreover, Schr\"odinger cat states of the field can enhance or suppress the optical potential depending on whether they are odd or even. Considering the nanospheres trapped by optical tweezers, we examine the total interparticle potential as a function of various experimentally relevant parameters, such as the field intensity, polarization, and phase of the trapping lasers. We demonstrate that an appropriate set of parameters could produce mutual bound states of the two nanospheres with potential depth as large as $\sim200$ K. Our results are pertinent to ongoing experiments with trapped nanospheres in the macroscopic quantum regime, paving the way for engineering interactions among macroscopic quantum systems.
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- 2023
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269. GistScore: Learning Better Representations for In-Context Example Selection with Gist Bottlenecks
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Gupta, Shivanshu, Rosenbaum, Clemens, and Elenberg, Ethan R.
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Computer Science - Computation and Language - Abstract
In-context Learning (ICL) is the ability of Large Language Models (LLMs) to perform new tasks when conditioned on prompts comprising a few task examples. However, ICL performance can be critically sensitive to the choice of examples. To dynamically select the best examples for every test input, we propose Example Gisting, a novel approach for training example encoders through supervised fine-tuning with an attention bottleneck between the inputs and outputs. These gist models form the basis for GistScore, a novel metric for scoring and selecting informative examples. Further, we experiment with two variations: (1) fine-tuning gist models for each dataset and (2) multi-task training a single model on a large collection of datasets. The latter can be used for new tasks out-of-the-box, enabling a training-free ICL pipeline. Evaluations with 21 datasets spanning 9 tasks and 8 diverse LLMs show that our fine-tuned models get state-of-the-art ICL performance with over 20% absolute gain over off-the-shelf retrievers and 5% over the best prior methods. Further, our multi-task model generalizes well to new tasks, datasets, and prompt templates. Selection using this model matches or outperforms prior methods while being three orders of magnitude faster than the strongest training-free baseline.
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- 2023
270. Magnetic fields of the starless core L 1512
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Lin, Sheng-Jun, Lai, Shih-Ping, Pattle, Kate, Berry, David, Clemens, Dan P., Pagani, Laurent, Ward-Thompson, Derek, Thieme, Travis J., and Ching, Tao-Chung
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Astrophysics - Astrophysics of Galaxies - Abstract
We present JCMT POL-2 850 um dust polarization observations and Mimir H band stellar polarization observations toward the starless core L1512. We detect the highly-ordered core-scale magnetic field traced by the POL-2 data, of which the field orientation is consistent with the parsec-scale magnetic fields traced by Planck data, suggesting the large-scale fields thread from the low-density region to the dense core region in this cloud. The surrounding magnetic field traced by the Mimir data shows a wider variation in the field orientation, suggesting there could be a transition of magnetic field morphology at the envelope scale. L1512 was suggested to be presumably older than 1.4 Myr in a previous study via time-dependent chemical analysis, hinting that the magnetic field could be strong enough to slow the collapse of L1512. In this study, we use the Davis-Chandrasekhar-Fermi method to derive a plane-of-sky magnetic field strength ($B_{pos}$) of 18$\pm$7 uG and an observed mass-to-flux ratio ($\lambda_{obs}$) of 3.5$\pm$2.4, suggesting that L1512 is magnetically supercritical. However, the absence of significant infall motion and the presence of an oscillating envelope are inconsistent with the magnetically supercritical condition. Using a Virial analysis, we suggest the presence of a hitherto hidden line-of-sight magnetic field strength of ~27 uG with a mass-to-flux ratio ($\lambda_{tot}$) of ~1.6, in which case both magnetic and kinetic pressures are important in supporting the L1512 core. On the other hand, L1512 may have just reached supercriticality and will collapse at any time., Comment: 25 pages, 10 figures, accepted for publication in ApJ
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- 2023
271. Recycling of beta-Li3PS4-based all-solid-state Li-ion batteries: Interactions of electrode materials and electrolyte in a dissolution-based separation process
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Wissel, Kerstin, Haben, Aaron, Küster, Kathrin, Starke, Ulrich, Kautenburger, Ralf, Ensinger, Wolfgang, and Clemens, Oliver
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Condensed Matter - Materials Science - Abstract
All-solid-state batteries are currently developed at high pace and show a strong potential for market introduction within the next years. Though their performance has improved considerably over the last years, investigation of their sustainability and the development of suitable recycling strategies have received less attention. However, their potential for efficient circular processes must be accessed comprehensively. In this article, we investigate the separation of the solid electrolyte beta-Li3PS4 from different lithium transition metal oxide electrode materials (LiCoO2, LiMn2O4, LiNi0.8Mn0.1Co0.1O2, LiFePO4, LiNi0.85Co0.1Al0.05O2 and Li4Ti5O12) via an approach based on the dissolution and subsequent recrystallization of the thiophosphate using N-methylformamide as solvent. A combination of X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, inductively coupled plasma-mass spectrometry, iodometric titration and X-ray photoelectron spectroscopy as well as electrochemical impedance spectroscopy and electrochemical characterization was used to characterize the electrolyte and electrode materials before and after separation. We find that the presence of electrode materials in the dissolution process can lead to significant chemical reactions. These interactions can (but most not) lead to strong alteration of the electrochemical characteristics of the individual compounds. Thus, we show that an efficient recovery of materials will likely depend on the precise material combination within an all-solid-state battery.
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- 2023
272. Non-Uniform Magnetic Fields for Single-Electron Control
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Ballicchia, Mauro, Etl, Clemens, Nedjalkov, Mihail, and Weinbub, Josef
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Controlling single-electron states becomes increasingly important due to the wide-ranging advances in electron quantum optics. Single-electron control enables coherent manipulation of individual electrons and the ability to exploit the wave nature of electrons, which offers various opportunities for quantum information processing, sensing, and metrology. A unique opportunity offering new degrees of freedom for single-electron control is provided when considering non-uniform magnetic fields. Considering the modeling perspective, conventional electron quantum transport theories are commonly based on gauge-dependent electromagnetic potentials. A direct formulation in terms of intuitive electromagnetic fields is thus not possible. In an effort to rectify this, a gauge-invariant formulation of the Wigner equation for general electromagnetic fields has been proposed in [Nedjalkov et al., Phys. Rev. B., 2019, 99, 014423]. However, the complexity of this equation requires to derive a more convenient formulation for linear electromagnetic fields [Nedjalkov et al., Phys. Rev. A., 2022, 106, 052213]. This formulation directly includes the classical formulation of the Lorentz force and higher-order terms depending on the magnetic field gradient, that are negligible for small variations of the magnetic field. In this work, we generalize this equation in order to include a general, non-uniform electric field and a linear, non-uniform magnetic field. The thus obtained formulation has been applied to investigate the capabilities of a linear, non-uniform magnetic field to control single-electron states in terms of trajectory, interference patterns, and dispersion. This has led to explore a new type of transport inside electronic waveguides based on snake trajectories and also to explore the possibility to split wavepackets to realize edge states.
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- 2023
273. A quantum dot coupled to a suspended-beam mechanical resonator: from the unresolved- to the resolved-sideband regime
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Spinnler, Clemens, Nguyen, Giang N., Wang, Ying, Erbe, Marcel, Javadi, Alisa, Zhai, Liang, Scholz, Sven, Wieck, Andreas D., Ludwig, Arne, Lodahl, Peter, Midolo, Leonardo, and Warburton, Richard J.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics ,Quantum Physics - Abstract
We present experiments in which self-assembled InAs quantum dots are coupled to a thin, suspended-beam GaAs resonator. The quantum dots are driven resonantly and the resonance fluorescence is detected. The narrow quantum-dot linewidths, just a factor of three larger than the transform limit, result in a high sensitivity to the mechanical motion. We show that one quantum dot couples to eight mechanical modes spanning a frequency range from $30$ to $600~\mathrm{MHz}$: one quantum dot provides an extensive characterisation of the mechanical resonator. The coupling spans the unresolved-sideband to the resolved-sideband regimes. Finally, we present the first detection of thermally-driven phonon sidebands (at $4.2~\mathrm{K}$) in the resonance-fluoresence spectrum.
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- 2023
274. A single-photon emitter coupled to a phononic-crystal resonator in the resolved-sideband regime
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Spinnler, Clemens, Nguyen, Giang N., Wang, Ying, Zhai, Liang, Javadi, Alisa, Erbe, Marcel, Scholz, Sven, Wieck, Andreas D., Ludwig, Arne, Lodahl, Peter, Midolo, Leonardo, and Warburton, Richard J.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics ,Quantum Physics - Abstract
A promising route towards the heralded creation and annihilation of single-phonons is to couple a single-photon emitter to a mechanical resonator. The challenge lies in reaching the resolved-sideband regime with a large coupling rate and a high mechanical quality factor. We achieve all of this by coupling self-assembled InAs quantum dots to a small-mode-volume phononic-crystal resonator with mechanical frequency $\Omega_\mathrm{m}/2\pi = 1.466~\mathrm{GHz}$ and quality factor $Q_\mathrm{m} = 2.1\times10^3$. Thanks to the high coupling rate of $g_\mathrm{ep}/2\pi = 2.9~\mathrm{MHz}$, and by exploiting a matching condition between the effective Rabi and mechanical frequencies, we are able to observe the interaction between the two systems. Our results represent a major step towards quantum control of the mechanical resonator via a single-photon emitter.
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- 2023
275. The Repeating Flaring Activity of Blazar AO 0235+164
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Pedrosa, Juan Escudero, Agudo, Iván, Tramacere, Andrea, Marscher, Alan P., Jorstad, Svetlana, Weaver, Z. R., Casadio, Carolina, Thum, Clemens, Myserlis, Ioannis, Fuentes, Antonio, Traianou, Efthalia, Kim, Jae-Young, Kramer, Joana, López-Coto, Rubén, D'Ammando, Filippo, Bernardos, M., Bonnoli, Giacomo, Blinov, Dmitriy A., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionov, V. M., Larionova, L. V., Morozova, D. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., and Vasilyev, A. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Context. Blazar AO 0235+164, located at redshift z = 0.94, has undergone several sharp multi-spectral-range flaring episodes during the last decades. In particular, the episodes peaking in 2008 and 2015, that received extensive multi-wavelength coverage, exhibited interesting behavior. Aims. We study the actual origin of these two observed flares by constraining the properties of the observed photo-polarimetric variability, those of the broad-band spectral energy-distribution and the observed time-evolution behavior of the source as seen by ultra-high resolution total-flux and polarimetric Very-long-baseline interferometry (VLBI) imaging. Methods. The analysis of VLBI images allows us to constrain kinematic and geometrical parameters of the 7 mm jet. We use the Discrete Correlation Function to compute the statistical correlation and the delays between emission at different spectral ranges. Multi-epoch modeling of the spectral energy distributions allows us to propose specific models of emission; in particular for the unusual spectral features observed in this source in the X-ray region of the spectrum during strong multi spectral-range flares. Results. We find that these X-ray spectral features can be explained by an emission component originating in a separate particle distribution than the one responsible for the two standard blazar bumps. This is in agreement with the results of our correlation analysis that do not find a strong correlation between the X-rays and the remaining spectral ranges. We find that both external Compton dominated and synchrotron self-Compton dominated models can explain the observed spectral energy distributions. However, synchrotron self-Compton models are strongly favored by the delays and geometrical parameters inferred from the observations.
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- 2023
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276. Universal symmetry of optimal control at the microscale
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Loos, Sarah A. M., Monter, Samuel, Ginot, Felix, and Bechinger, Clemens
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Statistical Mechanics - Abstract
Optimizing the energy efficiency of driving processes provides valuable insights into the underlying physics and is of crucial importance for numerous applications, from biological processes to the design of machines and robots. Knowledge of optimal driving protocols is particularly valuable at the microscale, where energy supply is often limited. Here we investigate experimentally and theoretically the paradigmatic optimization problem of moving a potential carrying a load through a fluid, in a finite time and over a given distance, in such a way that the required work is minimal. An important step towards more realistic systems is the consideration of memory effects in the surrounding fluid, which are ubiquitous in real-world applications. Therefore, our experiments were performed in viscous and viscoelastic media, which are typical environments for synthetic and biological processes on the microscale. Despite marked differences between the protocols in both fluids, we find that the optimal control protocol and the corresponding average particle trajectory always obey a time-reversal symmetry. We show that this symmetry, which surprisingly applies here to a class of processes far from thermal equilibrium, holds universally for various systems, including active, granular, and long-range correlated media in their linear regimes. The uncovered symmetry provides a rigorous and versatile criterion for optimal control that greatly facilitates the search for energy-efficient transport strategies in a wide range of systems. Using a machine learning algorithm, we demonstrate that the algorithmic exploitation of time-reversal symmetry can significantly enhance the performance of numerical optimization algorithms., Comment: 16 pages with 10 figures, accepted for publication in PRX
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- 2023
277. Fast, multicolour optical sectioning over extended fields of view by combining interferometric SIM with machine learning
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Ward, Edward N., McClelland, Rebecca M., Lamb, Jacob R., Rubio-Sánchez, Roger, Christensen, Charles N., Mazumder, Bismoy, Kapsiani, Sofia, Mascheroni, Luca, Di Michele, Lorenzo, Schierle, Gabriele S. Kaminski, and Kaminski, Clemens F.
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Physics - Optics ,Electrical Engineering and Systems Science - Image and Video Processing ,Physics - Biological Physics - Abstract
Structured illumination can reject out-of-focus signal from a sample, enabling high-speed and high-contrast imaging over large areas with widefield detection optics. Currently, this optical-sectioning technique is limited by image reconstruction artefacts and the need for sequential imaging of multiple colour channels. We combine multicolour interferometric pattern generation with machine-learning processing, permitting high-contrast, real-time reconstruction of image data. The method is insensitive to background noise and unevenly phase-stepped illumination patterns. We validate the method in silico and demonstrate its application on diverse specimens, ranging from fixed and live biological cells to synthetic biosystems, imaging at up to 37 Hz across a 44 x 44 $\mu m^2$ field of view.
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- 2023
278. Proceedings of the First Workshop on Trends in Configurable Systems Analysis
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ter Beek, Maurice H. and Dubslaff, Clemens
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Computer Science - Software Engineering ,Computer Science - Formal Languages and Automata Theory ,Computer Science - Logic in Computer Science - Abstract
The analysis of configurable systems, i.e., systems those behaviors depend on parameters or support various features, is challenging due to the exponential blowup arising in the number of configuration options. This volume contains the post-proceedings of TiCSA 2023, the first workshop on Trends in Configurable Systems Analysis, where current challenges and solutions in configurable systems analysis were presented and discussed.
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- 2023
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279. Motility-induced clustering of active particles under soft confinement
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Knippenberg, Timo, Jayaram, Ashreya, Speck, Thomas, and Bechinger, Clemens
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Condensed Matter - Soft Condensed Matter - Abstract
We investigate the structural and dynamic properties of active Brownian particles (APs) confined within a soft annulus-shaped channel. Depending on the strength of the confinement and the P\'eclet number, we observe a novel re-entrant behavior that is not present in unconfined systems. Our findings are substantiated by numerical simulations and analytical considerations, revealing that this behavior arises from the strong coupling between the P\'eclet number and the effective confining dimensionality of the APs. Beyond highlighting the important influence of soft boundaries on APs, our research holds significance for future applications of micro-robotic systems.
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- 2023
280. Nanoscale transient polarization gratings
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Foglia, Laura, Wehinger, Björn, Perosa, Giovanni, Mincigrucci, Riccardo, Allaria, Enrico, Armillotta, Francesco, Brynes, Alexander, Cucini, Riccardo, De Angelis, Dario, De Ninno, Giovanni, Engel, W. Dieter, Fainozzi, Danny, Giannessi, Luca, Khatu, Nupur N., Laterza, Simone, Paltanin, Ettore, Pelli-Cresi, Jacopo Stefano, Penco, Giuseppe, Puntel, Denny, Ribič, Primož Rebernik, Sottocorona, Filippo, Trovò, Mauro, Schmising, Clemens von Korff, Yao, Kelvin, Masciovecchio, Claudio, Bonetti, Stefano, and Bencivenga, Filippo
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Condensed Matter - Materials Science ,Physics - Accelerator Physics ,Physics - Optics - Abstract
We present the generation of transient polarization gratings at the nanoscale, achieved using a tailored accelerator configuration of the FERMI free electron laser. We demonstrate the capabilities of such a transient polarization grating by comparing its induced dynamics with the ones triggered by a more conventional intensity grating on a thin film ferrimagnetic alloy. While the signal of the intensity grating is dominated by the thermoelastic response of the system, such a contribution is suppressed in the case of the polarization grating. This exposes helicity-dependent magnetization dynamics that have so-far remained hidden under the large thermally driven response. We anticipate nanoscale transient polarization gratings to become useful for the study of any physical, chemical and biological systems possessing chiral symmetry.
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- 2023
281. A Near Magnetic-to-kinetic Energy Equipartition Flare from the Relativistic Jet in AO 0235+164 during 2013-2019
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Cheong, Whee Yeon, Lee, Sang-Sung, Kim, Sang-Hyun, Kang, Sincheol, Kim, Jae Young, Rani, Bindu, Readhead, Anthony C. S., Kiehlmann, Sebastian, Lähteenmäki, Anne, Tornikoski, Merja, Tammi, Joni, Ramakrishnan, Venkatessh, Agudo, Iván, Fuentes, Antonio, Traianou, Efthalia, Escudero, Juan, Thum, Clemens, Myserlis, Ioannis, Casadio, Carolina, and Gurwell, Mark
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the multiwavelength flaring activity of the blazar AO 0235+164 during its recent active period from 2013 to 2019. From a discrete correlation function (DCF) analysis, we find a significant (>95%) correlation between radio and $\gamma$-ray light curves with flares at longer wavelengths following flares at shorter wavelengths. We identify a new jet component in 43 GHz VLBA data that was ejected from the radio core on MJD $57246^{+26}_{-30}$ (2015 August 12), during the peak of the 2015 radio flare. From the analysis of the jet component, we derived a Doppler factor of $\delta_{\rm var}=28.5\pm8.4$, a bulk Lorentz factor of $\Gamma=16.8^{+3.6}_{-3.1}$, and an intrinsic viewing angle of $\theta_{\rm v}=1.42^{+1.07}_{-0.52}\textrm{ degrees}$. Investigation of the quasi-simultaneous radio data revealed a partially absorbed spectrum with the turnover frequency varying in the range of $10-70$ GHz and the peak flux density varying in the range of $0.7-4$ Jy. We find the synchrotron self-absorption magnetic field strength to be $B_{\rm SSA}=15.3^{+12.6}_{-14.0}$ mG at the peak of the 2015 radio flare, which is comparable to the equipartition magnetic field strength of $B_{\rm EQ}=43.6^{+10.6}_{-10.4}$ mG calculated for the same epoch. Additional analysis of the radio emission region in the relativistic jet of AO 0235+164 suggests that it did not significantly deviate from equipartition during its recent flaring activity., Comment: 13 pages, 11 figures, 4 tables; Accepted for publication in MNRAS
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- 2023
282. Stabilization of associated prime ideals of monomial ideals -- Bounding the copersistence index
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Heuberger, Clemens, Rath, Jutta, and Rissner, Roswitha
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Mathematics - Commutative Algebra ,13F20, 16W50, 13A02, 90C10, 13B25, 13E05 - Abstract
The sequence $(\operatorname{Ass}(R/I^n))_{n\in\mathbb{N}}$ of associated primes of powers of a monomial ideal $I$ in a polynomial ring $R$ eventually stabilizes by a known result by Markus Brodmann. L\^e Tu\^an Hoa gives an upper bound for the index where the stabilization occurs. This bound depends on the generators of the ideal and is obtained by separately bounding the powers of $I$ after which said sequence is non-decreasing and non-increasing, respectively. In this paper, we focus on the latter and call the smallest such number the copersistence index. We take up the proof idea of L\^e Tu\^an Hoa, who exploits a certain system of inequalities whose solution sets store information about the associated primes of powers of $I$. However, these proofs are entangled with a specific choice for the system of inequalities. In contrast to that, we present a generic ansatz to obtain an upper bound for the copersistence index that is uncoupled from this choice of the system. We establish properties for a system of inequalities to be eligible for this approach to work. We construct two suitable inequality systems to demonstrate how this ansatz yields upper bounds for the copersistence index and compare them with Hoa's. One of the two systems leads to an improvement of the bound by an exponential factor.
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- 2023
283. Realizing Topological Superconductivity in Tunable Bose-Fermi Mixtures with Transition Metal Dichalcogenide Heterostructures
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Zerba, Caterina, Kuhlenkamp, Clemens, Imamoğlu, Ataç, and Knap, Michael
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Quantum Gases ,Condensed Matter - Strongly Correlated Electrons ,Quantum Physics - Abstract
Heterostructures of two-dimensional transition metal dichalcogenides (TMDs) are emerging as a promising platform for investigating exotic correlated states of matter. Here, we propose to engineer Bose-Fermi mixtures in these systems by coupling inter-layer excitons to doped charges in a trilayer structure. Their interactions are determined by the inter-layer trion, whose spin-selective nature allows excitons to mediate an attractive interaction between charge carriers of only one spin species. Remarkably, we find that this causes the system to become unstable to topological p+ip superconductivity at low temperatures. We then demonstrate a general mechanism to develop and control this unconventional state by tuning the trion binding energy using a solid-state Feshbach resonance., Comment: 11 pages, 5 figures. Final version
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- 2023
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284. Feshbach resonances of composite charge carrier states in atomically thin semiconductor heterostructures
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Wagner, Marcel, Ołdziejewski, Rafał, Rose, Félix, Köder, Verena, Kuhlenkamp, Clemens, İmamoğlu, Ataç, and Schmidt, Richard
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Quantum Gases ,Condensed Matter - Strongly Correlated Electrons ,Quantum Physics - Abstract
Feshbach resonances play a vital role in the success of cold atoms investigating strongly-correlated physics. The recent observation of their solid-state analog in the scattering of holes and intralayer excitons in transition metal dichalcogenides [Schwartz et al., Science 374, 336 (2021)] holds compelling promise for bringing fully controllable interactions to the field of semiconductors. Here, we demonstrate how tunneling-induced layer hybridization can lead to the emergence of two distinct classes of Feshbach resonances in atomically thin semiconductors. Based on microscopic scattering theory we show that these two types of Feshbach resonances allow to tune interactions between electrons and both short-lived intralayer, as well as long-lived interlayer excitons. We predict the exciton-electron scattering phase shift from first principles and show that the exciton-electron coupling is fully tunable from strong to vanishing interactions. The tunability of interactions opens the avenue to explore Bose-Fermi mixtures in solid-state systems in regimes that were previously only accessible in cold atom experiments., Comment: 6+3 pages, 4+1 figures
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- 2023
285. Wigner transport in linear electromagnetic fields
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Etl, Clemens, Ballicchia, Mauro, Nedjalkov, Mihail, and Weinbub, Josef
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Quantum Physics ,Mathematical Physics - Abstract
Applying a Weyl-Stratonovich transform to the evolution equation of the Wigner function in an electromagnetic field yields a multidimensional gauge-invariant equation which is numerically very challenging to solve. In this work, we apply simplifying assumptions for linear electromagnetic fields and the evolution of an electron in a plane (two-dimensional transport), which reduces the complexity and enables to gain first experiences with a gauge-invariant Wigner equation. We present an equation analysis and show that a finite difference approach for solving the high-order derivatives allows for reformulation into a Fredholm integral equation. The resolvent expansion of the latter contains consecutive integrals, which is favorable for Monte Carlo solution approaches. To that end, we present two stochastic (Monte Carlo) algorithms that evaluate averages of generic physical quantities or directly the Wigner function. The algorithms give rise to a quantum particle model, which interprets quantum transport in heuristic terms.
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- 2023
- Full Text
- View/download PDF
286. Centrality of the Fingerprint Core Location
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Ruzicka, Laurenz, Strobl, Bernhard, Kohn, Bernhard, and Heitzinger, Clemens
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Fingerprints have long been recognized as a unique and reliable means of personal identification. Central to the analysis and enhancement of fingerprints is the concept of the fingerprint core. Although the location of the core is used in many applications, to the best of our knowledge, this study is the first to investigate the empirical distribution of the core over a large, combined dataset of rolled, as well as plain fingerprint recordings. We identify and investigate the extent of incomplete rolling during the rolled fingerprint acquisition and investigate the centrality of the core. After correcting for the incomplete rolling, we find that the core deviates from the fingerprint center by 5.7% $\pm$ 5.2% to 7.6% $\pm$ 6.9%, depending on the finger. Additionally, we find that the assumption of normal distribution of the core position of plain fingerprint recordings cannot be rejected, but for rolled ones it can. Therefore, we use a multi-step process to find the distribution of the rolled fingerprint recordings. The process consists of an Anderson-Darling normality test, the Bayesian Information Criterion to reduce the number of possible candidate distributions and finally a Generalized Monte Carlo goodness-of-fit procedure to find the best fitting distribution. We find the non-central Fischer distribution best describes the cores' horizontal positions. Finally, we investigate the correlation between mean core position offset and the NFIQ 2 score and find that the NFIQ 2 prefers rolled fingerprint recordings where the core sits slightly below the fingerprint center.
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- 2023
287. Tool Wear Segmentation in Blanking Processes with Fully Convolutional Networks based Digital Image Processing
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Schlegel, Clemens, Molitor, Dirk Alexander, Kubik, Christian, Martin, Daniel Michael, and Groche, Peter
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
The extend of tool wear significantly affects blanking processes and has a decisive impact on product quality and productivity. For this reason, numerous scientists have addressed their research to wear monitoring systems in order to identify or even predict critical wear at an early stage. Existing approaches are mainly based on indirect monitoring using time series, which are used to detect critical wear states via thresholds or machine learning models. Nevertheless, differentiation between types of wear phenomena affecting the tool during blanking as well as quantification of worn surfaces is still limited in practice. While time series data provides partial insights into wear occurrence and evolution, direct monitoring techniques utilizing image data offer a more comprehensive perspective and increased robustness when dealing with varying process parameters. However, acquiring and processing this data in real-time is challenging. In particular, high dynamics combined with increasing strokes rates as well as the high dimensionality of image data have so far prevented the development of direct image-based monitoring systems. For this reason, this paper demonstrates how high-resolution images of tools at 600 spm can be captured and subsequently processed using semantic segmentation deep learning algorithms, more precisely Fully Convolutional Networks (FCN). 125,000 images of the tool are taken from successive strokes, and microscope images are captured to investigate the worn surfaces. Based on findings from the microscope images, selected images are labeled pixel by pixel according to their wear condition and used to train a FCN (U-Net).
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- 2023
288. Hadamard Domain Training with Integers for Class Incremental Quantized Learning
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Schiemer, Martin, Schaefer, Clemens JS, Vap, Jayden Parker, Horeni, Mark James, Wang, Yu Emma, Ye, Juan, and Joshi, Siddharth
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Computer Science - Machine Learning - Abstract
Continual learning is a desirable feature in many modern machine learning applications, which allows in-field adaptation and updating, ranging from accommodating distribution shift, to fine-tuning, and to learning new tasks. For applications with privacy and low latency requirements, the compute and memory demands imposed by continual learning can be cost-prohibitive for resource-constraint edge platforms. Reducing computational precision through fully quantized training (FQT) simultaneously reduces memory footprint and increases compute efficiency for both training and inference. However, aggressive quantization especially integer FQT typically degrades model accuracy to unacceptable levels. In this paper, we propose a technique that leverages inexpensive Hadamard transforms to enable low-precision training with only integer matrix multiplications. We further determine which tensors need stochastic rounding and propose tiled matrix multiplication to enable low-bit width accumulators. We demonstrate the effectiveness of our technique on several human activity recognition datasets and CIFAR100 in a class incremental learning setting. We achieve less than 0.5% and 3% accuracy degradation while we quantize all matrix multiplications inputs down to 4-bits with 8-bit accumulators.
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- 2023
289. Relative fixed points of functors
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Schoen, Ezra, Master, Jade, and Kupke, Clemens
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Mathematics - Category Theory ,Computer Science - Logic in Computer Science - Abstract
We show how the relatively initial or relatively terminal fixed points for a well-behaved functor $F$ form a pair of adjoint functors between $F$-coalgebras and $F$-algebras. We use the language of locally presentable categories to find sufficient conditions for existence of this adjunction. We show that relative fixed points may be characterized as (co)equalizers of the free (co)monad on $F$. In particular, when $F$ is a polynomial functor on $\mathsf{Set}$ the relative fixed points are a quotient or subset of the free term algebra or the cofree term coalgebra. We give examples of the relative fixed points for polynomial functors and an example which is the Sierpinski carpet. Lastly, we prove a general preservation result for relative fixed points., Comment: 26 pages
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- 2023
290. Integrated patient-to-room and nurse-to-patient assignment in hospital wards
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Brandt, Tabea, Klein, Tom Lorenz, Reuter-Oppermann, Melanie, Schäfer, Fabian, Thielen, Clemens, van de Vrugt, Maartje, and Viana, Joe
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Mathematics - Optimization and Control - Abstract
Assigning patients to rooms and nurses to patients are critical tasks within hospitals that directly affect patient and staff satisfaction, quality of care, and hospital efficiency. Both patient-to-room assignments and nurse-to-patient assignments are typically agreed upon at the ward level, and they interact in several ways such as jointly determining the walking distances nurses must cover between different patient rooms. This motivates to consider both problems jointly in an integrated fashion. This paper presents the first optimization models and algorithms for the integrated patient-to-room and nurse-to-patient assignment problem. We provide a mixed integer programming formulation of the integrated problem that considers the typical objectives from the single problems as well as additional objectives that can only be properly evaluated when integrating both problems. Moreover, motivated by the inherent complexity that results from integrating these two NP-hard and already computationally challenging problems, we devise an efficient heuristic for the integrated patient-to-room and nurse-to-patient assignment problem. To evaluate the running time and quality of the solution obtained with the heuristic, we conduct extensive computational experiments on both artificial and real-world instances. The artificial instances are generated by a parameterized instance generator for the integrated problem that is made freely available.
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- 2023
291. Applying Security Testing Techniques to Automotive Engineering
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Pekaric, Irdin, Sauerwein, Clemens, and Felderer, Michael
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Computer Science - Cryptography and Security ,Computer Science - Software Engineering - Abstract
The openness of modern IT systems and their permanent change make it challenging to keep these systems secure. A combination of regression and security testing called security regression testing, which ensures that changes made to a system do not harm its security, are therefore of high significance and the interest in such approaches has steadily increased. In this article we present a systematic classification of available security regression testing approaches based on a solid study of background and related work to sketch which parts of the research area seem to be well understood and evaluated, and which ones require further research. For this purpose we extract approaches relevant to security regression testing from computer science digital libraries based on a rigorous search and selection strategy. Then, we provide a classification of these according to security regression approach criteria: abstraction level, security issue, regression testing techniques, and tool support, as well as evaluation criteria, for instance evaluated system, maturity of the system, and evaluation measures. From the resulting classification we derive observations with regard to the abstraction level, regression testing techniques, tool support as well as evaluation, and finally identify several potential directions of future research.
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- 2023
- Full Text
- View/download PDF
292. Polar ionospheric currents and high temporal resolution geomagnetic field models
- Author
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Kloss, Clemens, Finlay, Christopher C., Laundal, Karl M., and Olsen, Nils
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Physics - Space Physics ,Physics - Geophysics - Abstract
Estimating high resolution models of the Earth's core magnetic field and its time variation in the polar regions requires that one can adequately account for magnetic signals produced by polar ionospheric currents, which vary on a wide range of time and length scales. Limitations of existing ionospheric field models in the challenging polar regions can adversely affect core field models, which in turn has important implications for studies of the core flow dynamics in those regions. Here we implement a new approach to co-estimate a climatological model of the ionospheric field together with a model of the internal and magnetospheric fields within the CHAOS geomagnetic field modelling framework. The parametrization of the ionospheric field exploits non-orthogonal magnetic coordinates and scales linearly with external driving parameters related to the solar wind and the interplanetary magnetic field. Using this approach we derive a new geomagnetic field model from measurements of the magnetic field collected by low Earth orbit satellites, which in addition to the internal field provides estimates of the typical current system in the polar ionosphere. We find that the time derivative of the estimated internal field is less contaminated by the polar currents, which is mostly visible in the zonal and near-zonal terms at high spherical harmonic degrees. Distinctive patches of strong secular variation at the core-mantle boundary, which have important implications for core dynamics, persist. Relaxing the temporal regularisation reveals annual oscillations, which could indicate remaining ionospheric field or related induced signals in the internal field model. Using principal component analysis we find that the annual oscillations mostly affect the zonal low-degree spherical harmonics of the internal field., Comment: 26 pages, 15 figures, 3 tables
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- 2023
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293. Arithmetical subword complexity of automatic sequences
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Konieczny, Jakub and Müllner, Clemens
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Mathematics - Number Theory ,Computer Science - Formal Languages and Automata Theory ,Mathematics - Combinatorics - Abstract
We fully classify automatic sequences $a$ over a finite alphabet $\Omega$ with the property that each word over $\Omega$ appears is $a$ along an arithmetic progression. Using the terminology introduced by Avgustinovich, Fon-Der-Flaass and Frid, these are the automatic sequences with the maximal possible arithmetical subword complexity. More generally, we obtain an asymptotic formula for arithmetical (and even polynomial) subword complexity of a given automatic sequence $a$., Comment: 14 pages, comments welcome
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- 2023
294. Object-Size-Driven Design of Convolutional Neural Networks: Virtual Axle Detection based on Raw Data
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Riedel, Henik, Lorenzen, Robert Steven, and Hübler, Clemens
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Computer Science - Computer Vision and Pattern Recognition - Abstract
As infrastructure ages, the need for efficient monitoring methods becomes increasingly critical. Bridge Weigh-In-Motion (BWIM) systems are crucial for cost-efficient load and thus residual service life determination of road and railway infrastructure. However, conventional BWIM systems require additional sensors for axle detection, which have to be installed in potentially inaccessible locations or in locations that interfere with bridge operation. This study addresses this challenge by replacing dedicated axle detectors with a novel approach to real-time detection of train axles using sensors arbitrarily placed on bridges. The proposed Virtual Axle Detector with Enhanced Receptive Field (VADER) has been validated on a single-track railway bridge, demonstrating that it achieves to detect 99.9% of axles with a spatial error of 3.69cm using only acceleration measurements. Using raw data as input outperforms the state-of-the-art spectrogram-based method in both speed and memory usage by 99%, making real-time application feasible for the first time. Additionally, we introduce the Maximum Receptive Field (MRF) rule, a novel approach to optimise hyperparameters of Convolutional Neural Networks (CNNs) based on the size of objects, which in this case relates to the fundamental frequency of a bridge. The MRF rule effectively narrows the hyperparameter search space, potentially replacing the need for extensive hyperparameter tuning. Since the MRF rule is theoretically applicable to all unstructured data, it could have implications for a wide range of deep learning problems from earthquake prediction to object recognition.
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- 2023
295. Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.
- Author
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Meier, Maria, Kantelhardt, Sina, Gurri, Laura, Stadler, Christina, Schmid, Marc, Clemens, Vera, ODonovan, Aoife, Boonmann, Cyril, Bürgin, David, and Unternaehrer, Eva
- Subjects
Childhood trauma ,DNA methylation ,Hannum’s clock ,Horvath’s clock ,Trauma infantil ,aceleración de la edad ,age deceleration ,early life stress ,edad epigenética ,epigenetic aging ,estrés temprano ,metilación del ADN ,reloj de Hannum ,reloj de Horvath ,trauma ,Humans ,Female ,Male ,Adult ,Epigenesis ,Genetic ,Surveys and Questionnaires ,DNA Methylation ,Adverse Childhood Experiences ,Young Adult ,Aging - Abstract
Background: Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined links between early adversity and epigenetic aging is growing, results have been heterogeneous.Objective: In the current work, we explored the link between early adversity and epigenetic aging in a sample of formerly out-of-home placed young adults.Method: A total of N = 117 young adults (32% women, age mean = 26.3 years, SD = 3.6 years) with previous youth residential care placements completed the Childhood Trauma Questionnaire (CTQ) and the Life Events Checklist (LEC-R) and provided blood samples for the analysis of DNA methylation using the Illumina Infinium MethylationEPIC BeadChip Microarray. Epigenetic age was estimated using Hovarths and Hannums epigenetic clocks. Furthermore, Hovarths and Hannums epigenetic age residuals were calculated as a proxy of epigenetic aging by regressing epigenetic age on chronological age. The statistical analysis plan was preregistered (https://osf.io/b9ev8).Results: Childhood trauma (CTQ) was negatively associated with Hannums epigenetic age residuals, β = -.23, p = .004 when controlling for sex, BMI, smoking status and proportional white blood cell type estimates. This association was driven by experiences of physical neglect, β = -.25, p = .001. Lifetime trauma exposure (LEC-R) was not a significant predictor of epigenetic age residuals.Conclusion: Childhood trauma, and physical neglect in particular, was associated with decelerated epigenetic aging in our sample. More studies focusing on formerly institutionalized at-risk populations are needed to better understand which factors affect stress-related adaptations following traumatic experiences.
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- 2024
296. Effects of N-glycans on the structure of human IgA2
- Author
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Ruocco, Valentina, Grünwald-Gruber, Clemens, Rad, Behzad, Tscheliessnig, Rupert, Hammel, Michal, and Strasser, Richard
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Biotechnology ,Cancer ,2.1 Biological and endogenous factors ,IgA antibodies ,N-linked glycan ,SAXS ,flexibility ,protein assembly ,protein stability ,Biochemistry and cell biology ,Medical biochemistry and metabolomics - Abstract
The transition of IgA antibodies into clinical development is crucial because they have the potential to create a new class of therapeutics with superior pathogen neutralization, cancer cell killing, and immunomodulation capacity compared to IgG. However, the biological role of IgA glycans in these processes needs to be better understood. This study provides a detailed biochemical, biophysical, and structural characterization of recombinant monomeric human IgA2, which varies in the amount/locations of attached glycans. Monomeric IgA2 antibodies were produced by removing the N-linked glycans in the CH1 and CH2 domains. The impact of glycans on oligomer formation, thermal stability, and receptor binding was evaluated. In addition, we performed a structural analysis of recombinant IgA2 in solution using Small Angle X-Ray Scattering (SAXS) to examine the effect of glycans on protein structure and flexibility. Our results indicate that the absence of glycans in the Fc tail region leads to higher-order aggregates. SAXS, combined with atomistic modeling, showed that the lack of glycans in the CH2 domain results in increased flexibility between the Fab and Fc domains and a different distribution of open and closed conformations in solution. When binding with the Fcα-receptor, the dissociation constant remains unaltered in the absence of glycans in the CH1 or CH2 domain, compared to the fully glycosylated protein. These results provide insights into N-glycans' function on IgA2, which could have important implications for developing more effective IgA-based therapeutics in the future.
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- 2024
297. Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States
- Author
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Fang, Fang, Clemens, John David, Zhang, Zuo-Feng, and Brewer, Timothy F
- Subjects
Epidemiology ,Public Health ,Health Sciences ,Vaccine Related ,Infectious Diseases ,Immunization ,Lung ,Emerging Infectious Diseases ,Prevention ,3.4 Vaccines ,Prevention of disease and conditions ,and promotion of well-being ,Good Health and Well Being ,Humans ,COVID-19 ,COVID-19 Vaccines ,United States ,Incidence ,SARS-CoV-2 ,Female ,Male ,Vaccine Efficacy ,Vaccination ,Middle Aged ,Adult ,Vaccination Coverage ,Immunization ,Secondary ,General Science & Technology - Abstract
BackgroundGiven the waning of vaccine effectiveness and the shifting of the most dominant strains in the U.S., it is imperative to understand the association between vaccination coverage and Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease and mortality at the community levels and whether that association might vary according to the dominant SARS-CoV-2 strains in the U.S.MethodsGeneralized estimating equations were used to estimate associations between U.S. county-level cumulative vaccination rates and booster distribution and the daily change in county-wide Coronavirus 2019 disease (COVID-19) risks and mortality during Alpha, Delta and Omicron predominance. Models were adjusted for potential confounders at both county and state level. A 2-week lag and a 4-week lag were introduced to assess vaccination rate impact on incidence and mortality, respectively.ResultsAmong 3,073 counties in 48 states, the average county population complete vaccination rate of all age groups was 50.79% as of March 11th, 2022. Each percentage increase in vaccination rates was associated with reduction of 4% (relative risk (RR) 0.9607 (95% confidence interval (CI): 0.9553, 0.9661)) and 3% (RR 0.9694 (95% CI: 0.9653, 0.9736)) in county-wide COVID-19 cases and mortality, respectively, when Alpha was the dominant variant. The associations between county-level vaccine rates and COVID-19 incidence diminished during the Delta and Omicron predominance. However, each percent increase in people receiving a booster shot was associated with reduction of 6% (RR 0.9356 (95% CI: 0.9235, 0.9479)) and 4% (RR 0.9595 (95% CI: 0.9431, 0.9761)) in COVID-19 incidence and mortality in the community, respectively, during the Omicron predominance.ConclusionsAssociations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunity over time. Vaccine boosters were associated with notable protection against Omicron disease and mortality.
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- 2024
298. The IAAM LTBP4 Haplotype is Protective Against Dystrophin-Deficient Cardiomyopathy.
- Author
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Bello, Luca, Sabbatini, Daniele, Fusto, Aurora, Gorgoglione, Domenico, Borin, Giovanni, Penzo, Martina, Riguzzi, Pietro, Villa, Matteo, Vianello, Sara, Calore, Chiara, Melacini, Paola, Vio, Riccardo, Barp, Andrea, DAngelo, Grazia, Gandossini, Sandra, Politano, Luisa, Berardinelli, Angela, Messina, Sonia, Vita, Gian, Pedemonte, Marina, Bruno, Claudio, Albamonte, Emilio, Sansone, Valeria, Baranello, Giovanni, Masson, Riccardo, Astrea, Guja, DAmico, Adele, Bertini, Enrico, Pane, Marika, Lucibello, Simona, Mercuri, Eugenio, Spurney, Christopher, Clemens, Paula, Morgenroth, Lauren, Gordish-Dressman, Heather, Hoffman, Eric, Pegoraro, Elena, and McDonald, Craig
- Subjects
Duchenne muscular dystrophy ,LTBP4 ,dilated cardiomyopathy ,genetic modifiers ,glucocorticoid treatment ,Humans ,Dystrophin ,Haplotypes ,Retrospective Studies ,Stroke Volume ,Ventricular Function ,Left ,Muscular Dystrophy ,Duchenne ,Cardiomyopathies ,Protein Isoforms ,Latent TGF-beta Binding Proteins - Abstract
BACKGROUND: Dilated cardiomyopathy (DCM) is a major complication of, and leading cause of mortality in Duchenne muscular dystrophy (DMD). Its severity, age at onset, and rate of progression display wide variability, whose molecular bases have been scarcely elucidated. Potential DCM-modifying factors include glucocorticoid (GC) and cardiological treatments, DMD mutation type and location, and variants in other genes. METHODS AND RESULTS: We retrospectively collected 3138 echocardiographic measurements of left ventricular ejection fraction (EF), shortening fraction (SF), and end-diastolic volume (EDV) from 819 DMD participants, 541 from an Italian multicentric cohort and 278 from the Cooperative International Neuromuscular Group Duchenne Natural History Study (CINRG-DNHS). Using generalized estimating equation (GEE) models, we estimated the yearly rate of decrease of EF (-0.80%) and SF (-0.41%), while EDV increase was not significantly associated with age. Utilizing a multivariate generalized estimating equation (GEE) model we observed that mutations preserving the expression of the C-terminal Dp71 isoform of dystrophin were correlated with decreased EDV (-11.01 mL/m2, p = 0.03) while for dp116 were correlated with decreased EF (-4.14%, p =
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- 2024
299. A collaboration team to build social service partnerships within a safety-net health system
- Author
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Carson, Savanna L, Cameron, Francesca, Lee, Diamond, Zúñiga, Diana, Poole, Kelli, Jones, Adjoa, Herman, Cristina, Ramirez, Mayra, Harlow, Simone, Johnson, Jeannette, Agonafer, Etsemaye P, Hong, Clemens S, and Brown, Arleen F
- Subjects
Health Services and Systems ,Public Health ,Health Sciences ,Clinical Research ,Behavioral and Social Science ,Health Services ,Prevention ,Health and social care services research ,8.1 Organisation and delivery of services ,Generic health relevance ,Good Health and Well Being ,Infant ,United States ,Humans ,Social Work ,Los Angeles ,Safety net ,Community engagement ,Health and social care integration ,Health disparities ,Social determinants of health ,Public Health and Health Services ,Epidemiology ,Health services and systems ,Public health - Abstract
BackgroundTo facilitate safety-net healthcare system partnerships with community social service providers, the Los Angeles County Department of Health Services (LAC DHS) created a new collaboration team to spur cross-agency social and medical referral networks and engage communities affected by health disparities as part of a Sect. 1115 Medicaid waiver in Los Angeles County entitled Whole Person Care-Los Angeles (WPC-LA).MethodsThis observational research reviews three years of collaboration team implementation (2018-2020) through Medicaid-reportable engagement reports, a collaboration team qualitative survey on challenges, facilitators, and recommendations for community engagement. Member reflections for survey findings were conducted with the collaboration team and LAC DHS WPC-LA leadership.ResultsCollaboration team Medicaid engagement reports (n = 144) reported > 2,700 events, reaching > 70,000 individuals through cross-agency and community-partnered meetings. The collaboration team survey (n = 9) and member reflection sessions portrayed engagement processes through outreach, service assessments, and facilitation of service partnerships. The collaboration team facilitated community engagement processes through countywide workgroups on justice-system diversion and African American infant and maternal health. Recommendations for future safety net health system engagement processes included assessing health system readiness for community engagement and identifying strategies to build mutually beneficial social service partnerships.ConclusionsA dedicated collaboration team allowed for bi-directional knowledge exchange between county services, populations with lived experience, and social services, identifying service gaps and recommendations. Engagement with communities affected by health disparities resulted in health system policy recommendations and changes.
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- 2024
300. Findings from the Longitudinal CINRG Becker Natural History Study.
- Author
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Clemens, Paula, Gordish-Dressman, Heather, Niizawa, Gabriela, Gorni, Ksenija, Guglieri, Michela, Connolly, Anne, Wicklund, Matthew, Bertorini, Tulio, Mah, Jean, Thangarajh, Mathula, Smith, Edward, Kuntz, Nancy, Mcdonald, Craig, Henricson, Erik, Upadhyayula, S, Byrne, Barry, Manousakis, Georgios, Harper, Amy, Iannaccone, Susan, and Dang, Utkarsh
- Subjects
Muscular dystrophies ,dystrophin ,muscle ,natural history ,skeletal ,Adult ,Adolescent ,Humans ,Child ,Muscular Dystrophy ,Duchenne ,Prospective Studies ,Cross-Sectional Studies ,Phenotype ,Myocardium - Abstract
BACKGROUND: Becker muscular dystrophy is an X-linked, genetic disorder causing progressive degeneration of skeletal and cardiac muscle, with a widely variable phenotype. OBJECTIVE: A 3-year, longitudinal, prospective dataset contributed by patients with confirmed Becker muscular dystrophy was analyzed to characterize the natural history of this disorder. A better understanding of the natural history is crucial to rigorous therapeutic trials. METHODS: A cohort of 83 patients with Becker muscular dystrophy (5-75 years at baseline) were followed for up to 3 years with annual assessments. Muscle and pulmonary function outcomes were analyzed herein. Age-stratified statistical analysis and modeling were conducted to analyze cross-sectional data, time-to-event data, and longitudinal data to characterize these clinical outcomes. RESULTS: Deletion mutations of dystrophin exons 45-47 or 45-48 were most common. Subgroup analysis showed greater pairwise association between motor outcomes at baseline than association between these outcomes and age. Stronger correlations between outcomes for adults than for those under 18 years were also observed. Using cross-sectional binning analysis, a ceiling effect was seen for North Star Ambulatory Assessment but not for other functional outcomes. Longitudinal analysis showed a decline in percentage predicted forced vital capacity over the life span. There was relative stability or improved median function for motor functional outcomes through childhood and adolescence and decreasing function with age thereafter. CONCLUSIONS: There is variable progression of outcomes resulting in significant heterogeneity of the clinical phenotype of Becker muscular dystrophy. Disease progression is largely manifest in adulthood. There are implications for clinical trial design revealed by this longitudinal analysis of a Becker natural history dataset.
- Published
- 2024
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