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3,602 results on '"Allison, F"'

251. Vincristine/irinotecan/temsirolimus upfront window treatment of high‐risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 Study Committee

Author

Thompson, Patrick A., primary, Malogolowkin, Marcio H., additional, Furman, Wayne L., additional, Piao, Jin, additional, Krailo, Mark D., additional, Chung, Nadia, additional, Brock, Lindsay, additional, Towbin, Alexander J., additional, McCarville, Elizabeth B., additional, Finegold, Milton J., additional, Ranganathan, Sarangarajan, additional, Dunn, Stephen P., additional, Langham, Max R., additional, McGahren, Eugene D., additional, Tiao, Gregory M., additional, Weldon, Christopher B., additional, O'Neill, Allison F., additional, Rodriguez‐Galindo, Carlos, additional, Meyers, Rebecka L., additional, and Katzenstein, Howard M., additional

Published
2023
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253. Data from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author

Charbonneau, Bridget, primary, Moysich, Kirsten B., primary, Kalli, Kimberly R., primary, Oberg, Ann L., primary, Vierkant, Robert A., primary, Fogarty, Zachary C., primary, Block, Matthew S., primary, Maurer, Matthew J., primary, Goergen, Krista M., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Rider, David N., primary, Preston, Claudia, primary, Hartmann, Lynn C., primary, Lawrenson, Kate, primary, Wang, Chen, primary, Tyrer, Jonathan, primary, Song, Honglin, primary, deFazio, Anna, primary, Johnatty, Sharon E., primary, Doherty, Jennifer A., primary, Phelan, Catherine M., primary, Sellers, Thomas A., primary, Ramirez, Starr M., primary, Vitonis, Allison F., primary, Terry, Kathryn L., primary, Van Den Berg, David, primary, Pike, Malcolm C., primary, Wu, Anna H., primary, Berchuck, Andrew, primary, Gentry-Maharaj, Aleksandra, primary, Ramus, Susan J., primary, Diergaarde, Brenda, primary, Shen, Howard, primary, Jensen, Allan, primary, Menkiszak, Janusz, primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Ziogas, Argyrios, primary, Rothstein, Joseph H., primary, McGuire, Valerie, primary, Sieh, Weiva, primary, Lester, Jenny, primary, Walsh, Christine, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Despierre, Evelyn, primary, Garcia-Closas, Montserrat, primary, Yang, Hannah, primary, Brinton, Louise A., primary, Spiewankiewicz, Beata, primary, Rzepecka, Iwona K., primary, Dansonka-Mieszkowska, Agnieszka, primary, Seibold, Petra, primary, Rudolph, Anja, primary, Paddock, Lisa E., primary, Orlow, Irene, primary, Lundvall, Lene, primary, Olson, Sara H., primary, Hogdall, Claus K., primary, Schwaab, Ira, primary, du Bois, Andreas, primary, Harter, Philipp, primary, Flanagan, James M., primary, Brown, Robert, primary, Paul, James, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Hein, Alexander, primary, Eccles, Diana, primary, Lurie, Galina, primary, Hays, Laura E., primary, Bean, Yukie T., primary, Pejovic, Tanja, primary, Goodman, Marc T., primary, Campbell, Ian, primary, Fasching, Peter A., primary, Konecny, Gottfried, primary, Kaye, Stanley B., primary, Heitz, Florian, primary, Hogdall, Estrid, primary, Bandera, Elisa V., primary, Chang-Claude, Jenny, primary, Kupryjanczyk, Jolanta, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Karlan, Beth Y., primary, Whittemore, Alice S., primary, Culver, Hoda Anton, primary, Gronwald, Jacek, primary, Levine, Douglas A., primary, Kjaer, Susanne K., primary, Menon, Usha, primary, Schildkraut, Joellen M., primary, Pearce, Celeste Leigh, primary, Cramer, Daniel W., primary, Rossing, Mary Anne, primary, Chenevix-Trench, Georgia, primary, Pharoah, Paul D.P., primary, Gayther, Simon A., primary, Ness, Roberta B., primary, Odunsi, Kunle, primary, Sucheston, Lara E., primary, Knutson, Keith L., primary, and Goode, Ellen L., primary

Published
2023
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256. Supplementary Tables 1 - 4 from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author

Charbonneau, Bridget, primary, Moysich, Kirsten B., primary, Kalli, Kimberly R., primary, Oberg, Ann L., primary, Vierkant, Robert A., primary, Fogarty, Zachary C., primary, Block, Matthew S., primary, Maurer, Matthew J., primary, Goergen, Krista M., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Rider, David N., primary, Preston, Claudia, primary, Hartmann, Lynn C., primary, Lawrenson, Kate, primary, Wang, Chen, primary, Tyrer, Jonathan, primary, Song, Honglin, primary, deFazio, Anna, primary, Johnatty, Sharon E., primary, Doherty, Jennifer A., primary, Phelan, Catherine M., primary, Sellers, Thomas A., primary, Ramirez, Starr M., primary, Vitonis, Allison F., primary, Terry, Kathryn L., primary, Van Den Berg, David, primary, Pike, Malcolm C., primary, Wu, Anna H., primary, Berchuck, Andrew, primary, Gentry-Maharaj, Aleksandra, primary, Ramus, Susan J., primary, Diergaarde, Brenda, primary, Shen, Howard, primary, Jensen, Allan, primary, Menkiszak, Janusz, primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Ziogas, Argyrios, primary, Rothstein, Joseph H., primary, McGuire, Valerie, primary, Sieh, Weiva, primary, Lester, Jenny, primary, Walsh, Christine, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Despierre, Evelyn, primary, Garcia-Closas, Montserrat, primary, Yang, Hannah, primary, Brinton, Louise A., primary, Spiewankiewicz, Beata, primary, Rzepecka, Iwona K., primary, Dansonka-Mieszkowska, Agnieszka, primary, Seibold, Petra, primary, Rudolph, Anja, primary, Paddock, Lisa E., primary, Orlow, Irene, primary, Lundvall, Lene, primary, Olson, Sara H., primary, Hogdall, Claus K., primary, Schwaab, Ira, primary, du Bois, Andreas, primary, Harter, Philipp, primary, Flanagan, James M., primary, Brown, Robert, primary, Paul, James, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Hein, Alexander, primary, Eccles, Diana, primary, Lurie, Galina, primary, Hays, Laura E., primary, Bean, Yukie T., primary, Pejovic, Tanja, primary, Goodman, Marc T., primary, Campbell, Ian, primary, Fasching, Peter A., primary, Konecny, Gottfried, primary, Kaye, Stanley B., primary, Heitz, Florian, primary, Hogdall, Estrid, primary, Bandera, Elisa V., primary, Chang-Claude, Jenny, primary, Kupryjanczyk, Jolanta, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Karlan, Beth Y., primary, Whittemore, Alice S., primary, Culver, Hoda Anton, primary, Gronwald, Jacek, primary, Levine, Douglas A., primary, Kjaer, Susanne K., primary, Menon, Usha, primary, Schildkraut, Joellen M., primary, Pearce, Celeste Leigh, primary, Cramer, Daniel W., primary, Rossing, Mary Anne, primary, Chenevix-Trench, Georgia, primary, Pharoah, Paul D.P., primary, Gayther, Simon A., primary, Ness, Roberta B., primary, Odunsi, Kunle, primary, Sucheston, Lara E., primary, Knutson, Keith L., primary, and Goode, Ellen L., primary

Published
2023
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257. Figure S6A from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Winham, Stacey J., primary, Pirie, Ailith, primary, Chen, Yian Ann, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Earp, Madalene A., primary, Anton-Culver, Hoda, primary, Bandera, Elisa V., primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Goodman, Marc T., primary, Gronwald, Jacek, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Menon, Usha, primary, Ness, Roberta B., primary, Pearce, Celeste L., primary, Pejovic, Tanja, primary, Rossing, Mary Anne, primary, Wentzensen, Nicolas, primary, Bean, Yukie T., primary, Bisogna, Maria, primary, Brinton, Louise A., primary, Carney, Michael E., primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, deFazio, Anna, primary, Dicks, Ed M., primary, Edwards, Robert P., primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Gore, Martin, primary, Iversen, Edwin S., primary, Jensen, Allan, primary, Johnatty, Sharon E., primary, Lester, Jenny, primary, Lin, Hui-Yi, primary, Lissowska, Jolanta, primary, Lubinski, Jan, primary, Menkiszak, Janusz, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Orlow, Irene, primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Song, Honglin, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Tyrer, Jonathan P., primary, van den Berg, David J., primary, Vierkant, Robert A., primary, Vitonis, Allison F., primary, Walsh, Christine, primary, Wilkens, Lynne R., primary, Wu, Anna H., primary, Yang, Hannah, primary, Ziogas, Argyrios, primary, Berchuck, Andrew, primary, Schildkraut, Joellen M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pharoah, Paul D.P., primary, Fridley, Brooke L., primary, Sellers, Thomas A., primary, and Goode, Ellen L., primary

Published
2023
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258. Supplemental Table S1 from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Author

Wang, Sarah, primary, Hwang, Elizabeth E., primary, Guha, Rajarshi, primary, O'Neill, Allison F., primary, Melong, Nicole, primary, Veinotte, Chansey J., primary, Conway Saur, Amy, primary, Wuerthele, Kellsey, primary, Shen, Min, primary, McKnight, Crystal, primary, Alexe, Gabriela, primary, Lemieux, Madeleine E., primary, Wang, Amy, primary, Hughes, Emma, primary, Xu, Xin, primary, Boxer, Matthew B., primary, Hall, Matthew D., primary, Kung, Andrew, primary, Berman, Jason N., primary, Davis, Mindy I., primary, Stegmaier, Kimberly, primary, and Crompton, Brian D., primary

Published
2023
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259. Evaluation of added discriminatory ability from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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260. Spearman coefficients of correlation from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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261. Supplemental Figure Legends from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Winham, Stacey J., primary, Pirie, Ailith, primary, Chen, Yian Ann, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Earp, Madalene A., primary, Anton-Culver, Hoda, primary, Bandera, Elisa V., primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Goodman, Marc T., primary, Gronwald, Jacek, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Menon, Usha, primary, Ness, Roberta B., primary, Pearce, Celeste L., primary, Pejovic, Tanja, primary, Rossing, Mary Anne, primary, Wentzensen, Nicolas, primary, Bean, Yukie T., primary, Bisogna, Maria, primary, Brinton, Louise A., primary, Carney, Michael E., primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, deFazio, Anna, primary, Dicks, Ed M., primary, Edwards, Robert P., primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Gore, Martin, primary, Iversen, Edwin S., primary, Jensen, Allan, primary, Johnatty, Sharon E., primary, Lester, Jenny, primary, Lin, Hui-Yi, primary, Lissowska, Jolanta, primary, Lubinski, Jan, primary, Menkiszak, Janusz, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Orlow, Irene, primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Song, Honglin, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Tyrer, Jonathan P., primary, van den Berg, David J., primary, Vierkant, Robert A., primary, Vitonis, Allison F., primary, Walsh, Christine, primary, Wilkens, Lynne R., primary, Wu, Anna H., primary, Yang, Hannah, primary, Ziogas, Argyrios, primary, Berchuck, Andrew, primary, Schildkraut, Joellen M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pharoah, Paul D.P., primary, Fridley, Brooke L., primary, Sellers, Thomas A., primary, and Goode, Ellen L., primary

Published
2023
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262. Supplemental Tables from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Winham, Stacey J., primary, Pirie, Ailith, primary, Chen, Yian Ann, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Earp, Madalene A., primary, Anton-Culver, Hoda, primary, Bandera, Elisa V., primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Goodman, Marc T., primary, Gronwald, Jacek, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Menon, Usha, primary, Ness, Roberta B., primary, Pearce, Celeste L., primary, Pejovic, Tanja, primary, Rossing, Mary Anne, primary, Wentzensen, Nicolas, primary, Bean, Yukie T., primary, Bisogna, Maria, primary, Brinton, Louise A., primary, Carney, Michael E., primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, deFazio, Anna, primary, Dicks, Ed M., primary, Edwards, Robert P., primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Gore, Martin, primary, Iversen, Edwin S., primary, Jensen, Allan, primary, Johnatty, Sharon E., primary, Lester, Jenny, primary, Lin, Hui-Yi, primary, Lissowska, Jolanta, primary, Lubinski, Jan, primary, Menkiszak, Janusz, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Orlow, Irene, primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Song, Honglin, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Tyrer, Jonathan P., primary, van den Berg, David J., primary, Vierkant, Robert A., primary, Vitonis, Allison F., primary, Walsh, Christine, primary, Wilkens, Lynne R., primary, Wu, Anna H., primary, Yang, Hannah, primary, Ziogas, Argyrios, primary, Berchuck, Andrew, primary, Schildkraut, Joellen M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pharoah, Paul D.P., primary, Fridley, Brooke L., primary, Sellers, Thomas A., primary, and Goode, Ellen L., primary

Published
2023
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263. Data from Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author

Block, Matthew S., primary, Charbonneau, Bridget, primary, Vierkant, Robert A., primary, Fogarty, Zachary, primary, Bamlet, William R., primary, Pharoah, Paul D.P., primary, Rossing, Mary Anne, primary, Cramer, Daniel, primary, Pearce, Celeste Leigh, primary, Schildkraut, Joellen, primary, Menon, Usha, primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Gronwald, Jacek, primary, Culver, Hoda Anton, primary, Whittemore, Alice S., primary, Karlan, Beth Y., primary, Lambrechts, Diether, primary, Wentzensen, Nicolas, primary, Kupryjanczyk, Jolanta, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Fasching, Peter A., primary, Campbell, Ian, primary, Goodman, Marc T., primary, Pejovic, Tanja, primary, Bean, Yukie T., primary, Hays, Laura E., primary, Lurie, Galina, primary, Eccles, Diana, primary, Hein, Alexander, primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Paul, James, primary, Brown, Robert, primary, Flanagan, James M., primary, Harter, Philipp, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Hogdall, Claus K., primary, Lundvall, Lene, primary, Olson, Sara H., primary, Orlow, Irene, primary, Paddock, Lisa E., primary, Rudolph, Anja, primary, Eilber, Ursula, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Ziolkowska-Seta, Izabela, primary, Brinton, Louise A., primary, Yang, Hannah, primary, Garcia-Closas, Montserrat, primary, Despierre, Evelyn, primary, Lambrechts, Sandrina, primary, Vergote, Ignace, primary, Walsh, Christine S., primary, Lester, Jenny, primary, Sieh, Weiva, primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Ziogas, Argyrios, primary, Lubiński, Jan, primary, Cybulski, Cezary, primary, Menkiszak, Janusz, primary, Jensen, Allan, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Berchuck, Andrew, primary, Wu, Anna H., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Terry, Kathryn L., primary, Vitonis, Allison F., primary, Ramirez, Starr M., primary, Rider, David N., primary, Knutson, Keith L., primary, Sellers, Thomas A., primary, Phelan, Catherine M., primary, Doherty, Jennifer A., primary, Johnatty, Sharon E., primary, deFazio, Anna, primary, Song, Honglin, primary, Tyrer, Jonathan, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, and Goode, Ellen L., primary

Published
2023
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264. Supplementary Data from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Author

Wang, Sarah, primary, Hwang, Elizabeth E., primary, Guha, Rajarshi, primary, O'Neill, Allison F., primary, Melong, Nicole, primary, Veinotte, Chansey J., primary, Conway Saur, Amy, primary, Wuerthele, Kellsey, primary, Shen, Min, primary, McKnight, Crystal, primary, Alexe, Gabriela, primary, Lemieux, Madeleine E., primary, Wang, Amy, primary, Hughes, Emma, primary, Xu, Xin, primary, Boxer, Matthew B., primary, Hall, Matthew D., primary, Kung, Andrew, primary, Berman, Jason N., primary, Davis, Mindy I., primary, Stegmaier, Kimberly, primary, and Crompton, Brian D., primary

Published
2023
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265. Data from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Winham, Stacey J., primary, Pirie, Ailith, primary, Chen, Yian Ann, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Earp, Madalene A., primary, Anton-Culver, Hoda, primary, Bandera, Elisa V., primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Goodman, Marc T., primary, Gronwald, Jacek, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Menon, Usha, primary, Ness, Roberta B., primary, Pearce, Celeste L., primary, Pejovic, Tanja, primary, Rossing, Mary Anne, primary, Wentzensen, Nicolas, primary, Bean, Yukie T., primary, Bisogna, Maria, primary, Brinton, Louise A., primary, Carney, Michael E., primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, deFazio, Anna, primary, Dicks, Ed M., primary, Edwards, Robert P., primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Gore, Martin, primary, Iversen, Edwin S., primary, Jensen, Allan, primary, Johnatty, Sharon E., primary, Lester, Jenny, primary, Lin, Hui-Yi, primary, Lissowska, Jolanta, primary, Lubinski, Jan, primary, Menkiszak, Janusz, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Orlow, Irene, primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Song, Honglin, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Tyrer, Jonathan P., primary, van den Berg, David J., primary, Vierkant, Robert A., primary, Vitonis, Allison F., primary, Walsh, Christine, primary, Wilkens, Lynne R., primary, Wu, Anna H., primary, Yang, Hannah, primary, Ziogas, Argyrios, primary, Berchuck, Andrew, primary, Schildkraut, Joellen M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pharoah, Paul D.P., primary, Fridley, Brooke L., primary, Sellers, Thomas A., primary, and Goode, Ellen L., primary

Published
2023
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267. ROC curves and C-statistics by tumor stage from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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269. C-statistics by tumor histology from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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270. Supplementary Tables 1 through 3 from Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author

Block, Matthew S., primary, Charbonneau, Bridget, primary, Vierkant, Robert A., primary, Fogarty, Zachary, primary, Bamlet, William R., primary, Pharoah, Paul D.P., primary, Rossing, Mary Anne, primary, Cramer, Daniel, primary, Pearce, Celeste Leigh, primary, Schildkraut, Joellen, primary, Menon, Usha, primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Gronwald, Jacek, primary, Culver, Hoda Anton, primary, Whittemore, Alice S., primary, Karlan, Beth Y., primary, Lambrechts, Diether, primary, Wentzensen, Nicolas, primary, Kupryjanczyk, Jolanta, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Fasching, Peter A., primary, Campbell, Ian, primary, Goodman, Marc T., primary, Pejovic, Tanja, primary, Bean, Yukie T., primary, Hays, Laura E., primary, Lurie, Galina, primary, Eccles, Diana, primary, Hein, Alexander, primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Paul, James, primary, Brown, Robert, primary, Flanagan, James M., primary, Harter, Philipp, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Hogdall, Claus K., primary, Lundvall, Lene, primary, Olson, Sara H., primary, Orlow, Irene, primary, Paddock, Lisa E., primary, Rudolph, Anja, primary, Eilber, Ursula, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Ziolkowska-Seta, Izabela, primary, Brinton, Louise A., primary, Yang, Hannah, primary, Garcia-Closas, Montserrat, primary, Despierre, Evelyn, primary, Lambrechts, Sandrina, primary, Vergote, Ignace, primary, Walsh, Christine S., primary, Lester, Jenny, primary, Sieh, Weiva, primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Ziogas, Argyrios, primary, Lubiński, Jan, primary, Cybulski, Cezary, primary, Menkiszak, Janusz, primary, Jensen, Allan, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Berchuck, Andrew, primary, Wu, Anna H., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Terry, Kathryn L., primary, Vitonis, Allison F., primary, Ramirez, Starr M., primary, Rider, David N., primary, Knutson, Keith L., primary, Sellers, Thomas A., primary, Phelan, Catherine M., primary, Doherty, Jennifer A., primary, Johnatty, Sharon E., primary, deFazio, Anna, primary, Song, Honglin, primary, Tyrer, Jonathan, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, and Goode, Ellen L., primary

Published
2023
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271. Case characteristics from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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272. Data from Risk of Ovarian Cancer and the NF-κB Pathway: Genetic Association with IL1A and TNFSF10

Author

Charbonneau, Bridget, primary, Block, Matthew S., primary, Bamlet, William R., primary, Vierkant, Robert A., primary, Kalli, Kimberly R., primary, Fogarty, Zachary, primary, Rider, David N., primary, Sellers, Thomas A., primary, Tworoger, Shelley S., primary, Poole, Elizabeth, primary, Risch, Harvey A., primary, Salvesen, Helga B., primary, Kiemeney, Lambertus A., primary, Baglietto, Laura, primary, Giles, Graham G., primary, Severi, Gianluca, primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Chenevix-Trench, Georgia, primary, Whittemore, Alice S., primary, Sieh, Weiva, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Terry, Kathryn, primary, Goodman, Marc T., primary, Thompson, Pamela J., primary, Cook, Linda S., primary, Rossing, Mary Anne, primary, Ness, Roberta B., primary, Narod, Steven A., primary, Kupryjanczyk, Jolanta, primary, Lu, Karen, primary, Butzow, Ralf, primary, Dörk, Thilo, primary, Pejovic, Tanja, primary, Campbell, Ian, primary, Le, Nhu D., primary, Bunker, Clareann H., primary, Bogdanova, Natalia, primary, Runnebaum, Ingo B., primary, Eccles, Diana, primary, Paul, James, primary, Wu, Anna H., primary, Gayther, Simon A., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Karlan, Beth Y., primary, Anton-Culver, Hoda, primary, Gronwald, Jacek, primary, Hogdall, Claus K., primary, Lambrechts, Diether, primary, Fasching, Peter A., primary, Menon, Usha, primary, Schildkraut, Joellen, primary, Pearce, Celeste Leigh, primary, Levine, Douglas A., primary, Kjaer, Susanne Kruger, primary, Cramer, Daniel, primary, Flanagan, James M., primary, Phelan, Catherine M., primary, Brown, Robert, primary, Massuger, Leon F.A.G., primary, Song, Honglin, primary, Doherty, Jennifer A., primary, Krakstad, Camilla, primary, Liang, Dong, primary, Odunsi, Kunle, primary, Berchuck, Andrew, primary, Jensen, Allan, primary, Lubiński, Jan, primary, Nevanlinna, Heli, primary, Bean, Yukie T., primary, Lurie, Galina, primary, Ziogas, Argyrios, primary, Walsh, Christine, primary, Despierre, Evelyn, primary, Brinton, Louise, primary, Hein, Alexander, primary, Rudolph, Anja, primary, Dansonka-Mieszkowska, Agnieszka, primary, Olson, Sara H., primary, Harter, Philipp, primary, Tyrer, Jonathan, primary, Vitonis, Allison F., primary, Brooks-Wilson, Angela, primary, Aben, Katja K., primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Wik, Elisabeth, primary, Cybulski, Cezary, primary, Lin, Jie, primary, Sucheston, Lara, primary, Edwards, Robert, primary, McGuire, Valerie, primary, Lester, Jenny, primary, du Bois, Andreas, primary, Lundvall, Lene, primary, Wang-Gohrke, Shan, primary, Szafron, Lukasz M., primary, Lambrechts, Sandrina, primary, Yang, Hannah, primary, Beckmann, Matthias W., primary, Pelttari, Liisa M., primary, Van Altena, Anne M., primary, van den Berg, David, primary, Halle, Mari K., primary, Gentry-Maharaj, Aleksandra, primary, Schwaab, Ira, primary, Chandran, Urmila, primary, Menkiszak, Janusz, primary, Ekici, Arif B., primary, Wilkens, Lynne R., primary, Leminen, Arto, primary, Modugno, Francesmary, primary, Friel, Grace, primary, Rothstein, Joseph H., primary, Vergote, Ignace, primary, Garcia-Closas, Montserrat, primary, Hildebrandt, Michelle A.T., primary, Sobiczewski, Piotr, primary, Kelemen, Linda E., primary, Pharoah, Paul D.P., primary, Moysich, Kirsten, primary, Knutson, Keith L., primary, Cunningham, Julie M., primary, Fridley, Brooke L., primary, and Goode, Ellen L., primary

Published
2023
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273. Supplementary Tables 1 - 5 from Risk of Ovarian Cancer and the NF-κB Pathway: Genetic Association with IL1A and TNFSF10

Author

Charbonneau, Bridget, primary, Block, Matthew S., primary, Bamlet, William R., primary, Vierkant, Robert A., primary, Kalli, Kimberly R., primary, Fogarty, Zachary, primary, Rider, David N., primary, Sellers, Thomas A., primary, Tworoger, Shelley S., primary, Poole, Elizabeth, primary, Risch, Harvey A., primary, Salvesen, Helga B., primary, Kiemeney, Lambertus A., primary, Baglietto, Laura, primary, Giles, Graham G., primary, Severi, Gianluca, primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Chenevix-Trench, Georgia, primary, Whittemore, Alice S., primary, Sieh, Weiva, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Terry, Kathryn, primary, Goodman, Marc T., primary, Thompson, Pamela J., primary, Cook, Linda S., primary, Rossing, Mary Anne, primary, Ness, Roberta B., primary, Narod, Steven A., primary, Kupryjanczyk, Jolanta, primary, Lu, Karen, primary, Butzow, Ralf, primary, Dörk, Thilo, primary, Pejovic, Tanja, primary, Campbell, Ian, primary, Le, Nhu D., primary, Bunker, Clareann H., primary, Bogdanova, Natalia, primary, Runnebaum, Ingo B., primary, Eccles, Diana, primary, Paul, James, primary, Wu, Anna H., primary, Gayther, Simon A., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Karlan, Beth Y., primary, Anton-Culver, Hoda, primary, Gronwald, Jacek, primary, Hogdall, Claus K., primary, Lambrechts, Diether, primary, Fasching, Peter A., primary, Menon, Usha, primary, Schildkraut, Joellen, primary, Pearce, Celeste Leigh, primary, Levine, Douglas A., primary, Kjaer, Susanne Kruger, primary, Cramer, Daniel, primary, Flanagan, James M., primary, Phelan, Catherine M., primary, Brown, Robert, primary, Massuger, Leon F.A.G., primary, Song, Honglin, primary, Doherty, Jennifer A., primary, Krakstad, Camilla, primary, Liang, Dong, primary, Odunsi, Kunle, primary, Berchuck, Andrew, primary, Jensen, Allan, primary, Lubiński, Jan, primary, Nevanlinna, Heli, primary, Bean, Yukie T., primary, Lurie, Galina, primary, Ziogas, Argyrios, primary, Walsh, Christine, primary, Despierre, Evelyn, primary, Brinton, Louise, primary, Hein, Alexander, primary, Rudolph, Anja, primary, Dansonka-Mieszkowska, Agnieszka, primary, Olson, Sara H., primary, Harter, Philipp, primary, Tyrer, Jonathan, primary, Vitonis, Allison F., primary, Brooks-Wilson, Angela, primary, Aben, Katja K., primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Wik, Elisabeth, primary, Cybulski, Cezary, primary, Lin, Jie, primary, Sucheston, Lara, primary, Edwards, Robert, primary, McGuire, Valerie, primary, Lester, Jenny, primary, du Bois, Andreas, primary, Lundvall, Lene, primary, Wang-Gohrke, Shan, primary, Szafron, Lukasz M., primary, Lambrechts, Sandrina, primary, Yang, Hannah, primary, Beckmann, Matthias W., primary, Pelttari, Liisa M., primary, Van Altena, Anne M., primary, van den Berg, David, primary, Halle, Mari K., primary, Gentry-Maharaj, Aleksandra, primary, Schwaab, Ira, primary, Chandran, Urmila, primary, Menkiszak, Janusz, primary, Ekici, Arif B., primary, Wilkens, Lynne R., primary, Leminen, Arto, primary, Modugno, Francesmary, primary, Friel, Grace, primary, Rothstein, Joseph H., primary, Vergote, Ignace, primary, Garcia-Closas, Montserrat, primary, Hildebrandt, Michelle A.T., primary, Sobiczewski, Piotr, primary, Kelemen, Linda E., primary, Pharoah, Paul D.P., primary, Moysich, Kirsten, primary, Knutson, Keith L., primary, Cunningham, Julie M., primary, Fridley, Brooke L., primary, and Goode, Ellen L., primary

Published
2023
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278. Dynamical System Modeling of Immune Reconstitution after Allogeneic Stem Cell Transplantation Identifies Patients at Risk for Adverse Outcomes

Author

Toor, Amir A., Sabo, Roy T., Roberts, Catherine H., Moore, Bonny L., Salman, Salman R., Scalora, Allison F., Aziz, May T., Shubar Ali, Ali S., Hall, Charles E., Meier, Jeremy, Thorn, Radhika M., Wang, Elaine, Song, Shiyu, Miller, Kristin, Rizzo, Kathryn, Clark, William B., McCarty, John M., Chung, Harold M., Manjili, Masoud H., and Neale, Michael C.

Published
2015
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282. Association between endometriosis and lower urinary tract symptoms

Author

Iwona Gabriel, Allison F. Vitonis, Stacey A. Missmer, Ayòtúndé Fadayomi, Amy D. DiVasta, Kathryn L. Terry, and Vatche A. Minassian

Subjects
Adult, Cross-Sectional Studies, Adolescent, Lower Urinary Tract Symptoms, Reproductive Medicine, Surveys and Questionnaires, Urinary Incontinence, Stress, Endometriosis, Humans, Obstetrics and Gynecology, Female
Abstract

To determine if women with endometriosis experience lower urinary tract symptoms (LUTSs) more often than those without.Cross-sectional analysis at enrollment in a longitudinal cohort.Enrollment at 2 academic hospitals and from the local community.This analysis included 1,161 women with (n = 520) and without (n = 641) surgically confirmed endometriosis who were enrolled in the Women's Health Study: from Adolescence to Adulthood between 2012 and 2018.Not applicable.Prevalence of LUTSs, including stress incontinence, urgency and frequency, straining with urination, incomplete bladder emptying, hematuria, dysuria, and bladder pain using standardized questionnaires.The primary outcomes were that women with endometriosis reported the following more often than those without: difficulty passing urine (7.9% vs. 2%; crude odds ratio [OR], 4.14 [95% confidence interval {CI}, 2.19-7.80]; adjusted OR [aOR], 4.31 [95% CI, 2.07-8.95]); still feeling full after urination (18.8% vs. 4.7%; crude OR, 4.73 [95% CI, 3.08-7.25]; aOR, 4.67 [95% CI, 2.88-7.56]); having to urinate again within minutes of urinating (33.1% vs. 17.0%; crude OR, 2.41 [95% CI, 1.83-3.18]; aOR, 2.49 [95% CI, 1.81-3.43]), dysuria (11.7% vs. 4.9%; crude OR, 2.55 [95% CI, 1.62-4.01]; aOR, 2.38 [95% CI, 1.40-4.02]); and pain when the bladder is full (23.0% vs. 4.9%; crude OR, 5.79 [95% CI, 3.82-8.78]; aOR, 6.04 [95% CI, 3.74-9.76]). For the secondary outcomes, among female participants with endometriosis, we observed that the odds of LUTS did not differ by the revised American Society for Reproductive Medicine stage (I/II vs. III/IV) or duration of endometriosis-associated symptoms.Women with surgically confirmed endometriosis were more likely to report LUTS than those without.

Published
2022
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283. Moderators of the Association Between Teaching Students With Disabilities and General Education Teacher Turnover

Author

Allison F. Gilmour, Sabina R. Neugebauer, and Lia E. Sandilos

Subjects
mental disorders, education, Developmental and Educational Psychology, behavioral disciplines and activities, Education
Abstract

We examined the association between the percentage of students with disabilities (SWD) in general education teachers’ classes and their likelihood of turnover, investigating potential internal and external resources (certification, experience, preparation, classroom management, and working conditions) as moderators and disaggregating types of teacher mobility. Before accounting for other variables, the percentage of SWD, and the percentage of students with most specific disabilities, in teachers’ classes were positively associated with moving within and moving between districts. These associations were not significant after accounting for student, teacher, and school characteristics. We identified a negative association between leaving teaching in the state and the percentage of SWD in teachers’ classes, even after accounting for other variables. Dual-certification and instructional leadership moderated some of these associations. Results suggest that future research is needed to identify the supports teachers have access to when they teach higher percentages of SWD.

Published
2022
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284. Vincristine/irinotecan/temsirolimus upfront window treatment of high‐risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 Study Committee

Author

Patrick A. Thompson, Marcio H. Malogolowkin, Wayne L. Furman, Jin Piao, Mark D. Krailo, Nadia Chung, Lindsay Brock, Alexander J. Towbin, Elizabeth B. McCarville, Milton J. Finegold, Sarangarajan Ranganathan, Stephen P. Dunn, Max R. Langham, Eugene D. McGahren, Gregory M. Tiao, Christopher B. Weldon, Allison F. O'Neill, Carlos Rodriguez‐Galindo, Rebecka L. Meyers, and Howard M. Katzenstein

Subjects
Oncology, Pediatrics, Perinatology and Child Health, Hematology
Published
2023
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285. Supplementary Tables 1 - 4 from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author

Ellen L. Goode, Keith L. Knutson, Lara E. Sucheston, Kunle Odunsi, Roberta B. Ness, Simon A. Gayther, Paul D.P. Pharoah, Georgia Chenevix-Trench, Mary Anne Rossing, Daniel W. Cramer, Celeste Leigh Pearce, Joellen M. Schildkraut, Usha Menon, Susanne K. Kjaer, Douglas A. Levine, Jacek Gronwald, Hoda Anton Culver, Alice S. Whittemore, Beth Y. Karlan, Diether Lambrechts, Nicolas Wentzensen, Jolanta Kupryjanczyk, Jenny Chang-Claude, Elisa V. Bandera, Estrid Hogdall, Florian Heitz, Stanley B. Kaye, Gottfried Konecny, Peter A. Fasching, Ian Campbell, Marc T. Goodman, Tanja Pejovic, Yukie T. Bean, Laura E. Hays, Galina Lurie, Diana Eccles, Alexander Hein, Matthias W. Beckmann, Arif B. Ekici, James Paul, Robert Brown, James M. Flanagan, Philipp Harter, Andreas du Bois, Ira Schwaab, Claus K. Hogdall, Sara H. Olson, Lene Lundvall, Irene Orlow, Lisa E. Paddock, Anja Rudolph, Petra Seibold, Agnieszka Dansonka-Mieszkowska, Iwona K. Rzepecka, Beata Spiewankiewicz, Louise A. Brinton, Hannah Yang, Montserrat Garcia-Closas, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Christine Walsh, Jenny Lester, Weiva Sieh, Valerie McGuire, Joseph H. Rothstein, Argyrios Ziogas, Jan Lubiński, Cezary Cybulski, Janusz Menkiszak, Allan Jensen, Howard Shen, Brenda Diergaarde, Susan J. Ramus, Aleksandra Gentry-Maharaj, Andrew Berchuck, Anna H. Wu, Malcolm C. Pike, David Van Den Berg, Kathryn L. Terry, Allison F. Vitonis, Starr M. Ramirez, Thomas A. Sellers, Catherine M. Phelan, Jennifer A. Doherty, Sharon E. Johnatty, Anna deFazio, Honglin Song, Jonathan Tyrer, Chen Wang, Kate Lawrenson, Lynn C. Hartmann, Claudia Preston, David N. Rider, Julie M. Cunningham, Brooke L. Fridley, Krista M. Goergen, Matthew J. Maurer, Matthew S. Block, Zachary C. Fogarty, Robert A. Vierkant, Ann L. Oberg, Kimberly R. Kalli, Kirsten B. Moysich, and Bridget Charbonneau

Abstract

PDF file - 157K, Supplemental Table 1. Regulatory T cell genes included in this study (N=25). Supplemental Table 2. Regulatory T cell SNPs included in this study. Supplemental Table 3. Participating invasive epithelial ovarian cancer studies. Supplemental Table 4. Association between clinical variables and overall survival.

Published
2023
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286. Data from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author

Ellen L. Goode, Keith L. Knutson, Lara E. Sucheston, Kunle Odunsi, Roberta B. Ness, Simon A. Gayther, Paul D.P. Pharoah, Georgia Chenevix-Trench, Mary Anne Rossing, Daniel W. Cramer, Celeste Leigh Pearce, Joellen M. Schildkraut, Usha Menon, Susanne K. Kjaer, Douglas A. Levine, Jacek Gronwald, Hoda Anton Culver, Alice S. Whittemore, Beth Y. Karlan, Diether Lambrechts, Nicolas Wentzensen, Jolanta Kupryjanczyk, Jenny Chang-Claude, Elisa V. Bandera, Estrid Hogdall, Florian Heitz, Stanley B. Kaye, Gottfried Konecny, Peter A. Fasching, Ian Campbell, Marc T. Goodman, Tanja Pejovic, Yukie T. Bean, Laura E. Hays, Galina Lurie, Diana Eccles, Alexander Hein, Matthias W. Beckmann, Arif B. Ekici, James Paul, Robert Brown, James M. Flanagan, Philipp Harter, Andreas du Bois, Ira Schwaab, Claus K. Hogdall, Sara H. Olson, Lene Lundvall, Irene Orlow, Lisa E. Paddock, Anja Rudolph, Petra Seibold, Agnieszka Dansonka-Mieszkowska, Iwona K. Rzepecka, Beata Spiewankiewicz, Louise A. Brinton, Hannah Yang, Montserrat Garcia-Closas, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Christine Walsh, Jenny Lester, Weiva Sieh, Valerie McGuire, Joseph H. Rothstein, Argyrios Ziogas, Jan Lubiński, Cezary Cybulski, Janusz Menkiszak, Allan Jensen, Howard Shen, Brenda Diergaarde, Susan J. Ramus, Aleksandra Gentry-Maharaj, Andrew Berchuck, Anna H. Wu, Malcolm C. Pike, David Van Den Berg, Kathryn L. Terry, Allison F. Vitonis, Starr M. Ramirez, Thomas A. Sellers, Catherine M. Phelan, Jennifer A. Doherty, Sharon E. Johnatty, Anna deFazio, Honglin Song, Jonathan Tyrer, Chen Wang, Kate Lawrenson, Lynn C. Hartmann, Claudia Preston, David N. Rider, Julie M. Cunningham, Brooke L. Fridley, Krista M. Goergen, Matthew J. Maurer, Matthew S. Block, Zachary C. Fogarty, Robert A. Vierkant, Ann L. Oberg, Kimberly R. Kalli, Kirsten B. Moysich, and Bridget Charbonneau

Abstract

The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated genes (CD28, CTLA4, FOXP3, IDO1, IL10, IL10RA, IL15, 1L17RA, IL23A, IL23R, IL2RA, IL6, IL6R, IL8, LGALS1, LGALS9, MAP3K8, STAT5A, STAT5B, TGFB1, TGFB2, TGFB3, TGFBR1, TGRBR2, and TGFBR3) in relation to ovarian cancer survival. We analyzed genotype and overall survival in 10,084 women with invasive epithelial ovarian cancer, including 5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous carcinoma cases of European descent across 28 studies from the Ovarian Cancer Association Consortium (OCAC). The strongest associations were found for endometrioid carcinoma and IL2RA SNPs rs11256497 [HR, 1.42; 95% confidence interval (CI), 1.22–1.64; P = 5.7 × 10−6], rs791587 (HR, 1.36; 95% CI, 1.17–1.57; P = 6.2 × 10−5), rs2476491 (HR, = 1.40; 95% CI, 1.19–1.64; P = 5.6 × 10−5), and rs10795763 (HR, 1.35; 95% CI, 1.17–1.57; P = 7.9 × 10−5), and for clear cell carcinoma and CTLA4 SNP rs231775 (HR, 0.67; 95% CI, 0.54–0.82; P = 9.3 × 10−5) after adjustment for age, study site, population stratification, stage, grade, and oral contraceptive use. The rs231775 allele associated with improved survival in our study also results in an amino acid change in CTLA4 and previously has been reported to be associated with autoimmune conditions. Thus, we found evidence that SNPs in genes related to Tregs seem to play a role in ovarian cancer survival, particularly in patients with clear cell and endometrioid epithelial ovarian cancer. Cancer Immunol Res; 2(4); 332–40. ©2014 AACR.

Published
2023
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287. Supplementary Table S1, Table S2, Table S3, Table S4, Table S5 from Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk

Author

Kathryn L. Terry, Shelley S. Tworoger, Britton Trabert, Daniel W. Cramer, Linda Titus, Allison F. Vitonis, Ana Babic, and Naoko Sasamoto

Abstract

Supplementary Table S1 shows characteristics among ovarian cancer cases, Supplementary Table S2 shows the association between duration of analgesic use and ovarian cancer risk, Supplementary Table S3 shows the association between frequency of analgesic use and ovarian cancer risk, Supplementary Table S4 shows the association between age at first use of analgesics and ovarian cancer risk, Supplementary Table S5 shows the associations between analgesic use and ovarian cancer risk stratified by oral contraceptive use and history of endometriosis

Published
2023
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288. Data from Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk

Author

Kathryn L. Terry, Shelley S. Tworoger, Britton Trabert, Daniel W. Cramer, Linda Titus, Allison F. Vitonis, Ana Babic, and Naoko Sasamoto

Abstract

Menstrual pain has been associated with increased ovarian cancer risk, presumably through increased inflammation, which is known to play a critical role in ovarian carcinogenesis. Analgesic medications are frequently used to treat menstrual pain, some of which lower ovarian cancer risk. In this study, we examined the association between analgesic use for menstrual pain during the premenopausal period and ovarian cancer risk among women with history of menstrual pain. We used data from the New England Case-Control Study, including 1,187 epithelial ovarian cancer cases and 1,225 population-based controls enrolled between 1998 and 2008 with detailed information on analgesic use for their menstrual pain. We used unconditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between analgesic use (i.e., aspirin, ibuprofen, acetaminophen) for menstrual pain and ovarian cancer risk. We further conducted a stratified analysis by intensity of menstrual pain (mild/moderate, severe). Among women with menstrual pain during their 20s and 30s, ever use of analgesics for menstrual pain was not significantly associated with ovarian cancer risk. However, among women with severe menstrual pain, ever use of aspirin or acetaminophen for menstrual pain was inversely associated with risk (OR, 0.41; 95% CI, 0.18–0.94 and OR, 0.43; 95% CI, 0.21–0.88 compared with never users, respectively). No significant association was observed between analgesic use and ovarian cancer risk among women with mild/moderate menstrual pain (Pinteraction ≤ 0.03). Our results suggest that use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer.Prevention Relevance:This study investigates whether analgesic use specifically for menstrual pain during the premenopausal period influences ovarian cancer risk. Our results suggest use of aspirin or acetaminophen for severe menstrual pain may be associated with lower risk of ovarian cancer among women with severe menstrual pain.

Published
2023
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289. Data from Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a 64Cu-Labeled Anti-CD99 Antibody

Author

Andrew L. Kung, Alan B. Packard, Antonio R. Perez-Atayde, Monica L. Calicchio, Jon C. Aster, Yanping Sun, Tanya Tupper, Yuchuan Wang, Jason L.J. Dearling, and Allison F. O'Neill

Abstract

Purpose: Ewing sarcoma is a tumor of the bone and soft tissue characterized by diffuse cell membrane expression of CD99 (MIC2). Single-site, surgically resectable disease is associated with an excellent 5-year event-free survival; conversely, patients with distant metastases have a poor prognosis. Noninvasive imaging is the standard approach to identifying sites of metastatic disease. We sought to develop a CD99-targeted imaging agent for staging Ewing sarcoma and other CD99-expressing tumors.Experimental Design: We identified a CD99 antibody with highly specific binding in vitro and labeled this antibody with 64Cu. Mice with either subcutaneous Ewing sarcoma xenograft tumors or micrometastases were imaged with the 64Cu-labeled anti-CD99 antibody and these results were compared with conventional MRI and 2[18F]fluoro-2-deoxy-d-glucose–positron emission tomography (FDG–PET) imaging.Results:64Cu-labeled anti-CD99 antibody demonstrated high avidity for the CD99-positive subcutaneous tumors, with a high tumor-to-background ratio, greater than that demonstrated with FDG–PET. Micrometastases, measuring 1 to 2 mm on MRI, were not detected with FDG–PET but were readily visualized with the 64Cu-labeled anti-CD99 antibody. Probe biodistribution studies demonstrated high specificity of the probe for CD99-positive tumors.Conclusions:64Cu-labeled anti-CD99 antibody can detect subcutaneous Ewing sarcoma tumors and metastatic sites with high sensitivity, outperforming FDG–PET in preclinical studies. This targeted radiotracer may have important implications for the diagnosis, surveillance, and treatment of Ewing sarcoma. Similarly, it may impact the management of other CD99 positive tumors. Clin Cancer Res; 20(3); 678–87. ©2013 AACR.

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2023
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290. Figure S3 from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Ellen L. Goode, Thomas A. Sellers, Brooke L. Fridley, Paul D.P. Pharoah, Catherine M. Phelan, Jennifer Permuth-Wey, Joellen M. Schildkraut, Andrew Berchuck, Argyrios Ziogas, Hannah Yang, Anna H. Wu, Lynne R. Wilkens, Christine Walsh, Allison F. Vitonis, Robert A. Vierkant, David J. van den Berg, Jonathan P. Tyrer, Pamela J. Thompson, Kathryn L. Terry, Honglin Song, Susan J. Ramus, Malcolm C. Pike, Irene Orlow, Kirsten B. Moysich, Francesmary Modugno, Janusz Menkiszak, Jan Lubinski, Jolanta Lissowska, Hui-Yi Lin, Jenny Lester, Sharon E. Johnatty, Allan Jensen, Edwin S. Iversen, Martin Gore, Aleksandra Gentry-Maharaj, Simon A. Gayther, Robert P. Edwards, Ed M. Dicks, Anna deFazio, Cezary Cybulski, Julie M. Cunningham, Michael E. Carney, Louise A. Brinton, Maria Bisogna, Yukie T. Bean, Nicolas Wentzensen, Mary Anne Rossing, Tanja Pejovic, Celeste L. Pearce, Roberta B. Ness, Usha Menon, Douglas A. Levine, Susanne K. Kjaer, Beth Y. Karlan, Jacek Gronwald, Marc T. Goodman, Jennifer A. Doherty, Daniel Cramer, Elisa V. Bandera, Hoda Anton-Culver, Madalene A. Earp, Zachary C. Fogarty, Melissa C. Larson, Yian Ann Chen, Ailith Pirie, and Stacey J. Winham

Abstract

Supplemental Figure S 3

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2023
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291. Data from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Author

Brian D. Crompton, Kimberly Stegmaier, Mindy I. Davis, Jason N. Berman, Andrew Kung, Matthew D. Hall, Matthew B. Boxer, Xin Xu, Emma Hughes, Amy Wang, Madeleine E. Lemieux, Gabriela Alexe, Crystal McKnight, Min Shen, Kellsey Wuerthele, Amy Conway Saur, Chansey J. Veinotte, Nicole Melong, Allison F. O'Neill, Rajarshi Guha, Elizabeth E. Hwang, and Sarah Wang

Abstract

Purpose:Ewing sarcoma is an aggressive solid tumor malignancy of childhood. Although current treatment regimens cure approximately 70% of patients with localized disease, they are ineffective for most patients with metastases or relapse. New treatment combinations are necessary for these patients.Experimental Design:Ewing sarcoma cells are dependent on focal adhesion kinase (FAK) for growth. To identify candidate treatment combinations for Ewing sarcoma, we performed a small-molecule library screen to identify compounds synergistic with FAK inhibitors in impairing Ewing cell growth. The activity of a top-scoring class of compounds was then validated across multiple Ewing cell lines in vitro and in multiple xenograft models of Ewing sarcoma.Results:Numerous Aurora kinase inhibitors scored as synergistic with FAK inhibition in this screen. We found that Aurora kinase B inhibitors were synergistic across a larger range of concentrations than Aurora kinase A inhibitors when combined with FAK inhibitors in multiple Ewing cell lines. The combination of AZD-1152, an Aurora kinase B–selective inhibitor, and PF-562271 or VS-4718, FAK-selective inhibitors, induced apoptosis in Ewing sarcoma cells at concentrations that had minimal effects on survival when cells were treated with either drug alone. We also found that the combination significantly impaired tumor progression in multiple xenograft models of Ewing sarcoma.Conclusions:FAK and Aurora kinase B inhibitors synergistically impair Ewing sarcoma cell viability and significantly inhibit tumor progression. This study provides preclinical support for the consideration of a clinical trial testing the safety and efficacy of this combination for patients with Ewing sarcoma.

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2023
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292. C-statistics by tumor histology from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Rudolf Kaaks, Daniel W. Cramer, Elio Riboli, Melissa A. Merritt, Marc J. Gunter, Ruth C. Travis, Karl Smith Byrne, Kay-Tee Khaw, Nicholas J. Wareham, Jonas Manjer, Karin Jirström, Eva Lundin, Annika Idahl, Carmen Navarro, Nerea Etxezarreta, Eva Ardanaz, Maria-Jose Sanchez, Eric J. Duell, Elisabete Weiderpass, Inger Torhild Gram, Petra H. Peeters, N. Charlotte Onland-Moret, H. Bas Bueno-de-Mesquita, Salvatore Panico, Elisabetta Kuhn, Vittorio Krogh, Antonia Trichopoulou, Pagona Lagiou, Vassiliki Benetou, Heiner Boeing, Sabina Rinaldi, Laure Dossus, Gianluca Severi, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Anne Tjønneland, Kim Overvad, Theron Johnson, Allison F. Vitonis, Hidemi S. Yamamoto, Raina N. Fichorova, Anika Hüsing, Renée T. Fortner, Helena Schock, and Kathryn L. Terry

Abstract

C-statistics by tumor histology for variable lag-times since blood donation

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2023
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293. Data from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Rudolf Kaaks, Daniel W. Cramer, Elio Riboli, Melissa A. Merritt, Marc J. Gunter, Ruth C. Travis, Karl Smith Byrne, Kay-Tee Khaw, Nicholas J. Wareham, Jonas Manjer, Karin Jirström, Eva Lundin, Annika Idahl, Carmen Navarro, Nerea Etxezarreta, Eva Ardanaz, Maria-Jose Sanchez, Eric J. Duell, Elisabete Weiderpass, Inger Torhild Gram, Petra H. Peeters, N. Charlotte Onland-Moret, H. Bas Bueno-de-Mesquita, Salvatore Panico, Elisabetta Kuhn, Vittorio Krogh, Antonia Trichopoulou, Pagona Lagiou, Vassiliki Benetou, Heiner Boeing, Sabina Rinaldi, Laure Dossus, Gianluca Severi, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Anne Tjønneland, Kim Overvad, Theron Johnson, Allison F. Vitonis, Hidemi S. Yamamoto, Raina N. Fichorova, Anika Hüsing, Renée T. Fortner, Helena Schock, and Kathryn L. Terry

Abstract

Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.Experimental Design: We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.Results: We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.Conclusions: CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases. Clin Cancer Res; 22(18); 4664–75. ©2016 AACR.See related commentary by Skates, p. 4542

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2023
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294. Case characteristics from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Rudolf Kaaks, Daniel W. Cramer, Elio Riboli, Melissa A. Merritt, Marc J. Gunter, Ruth C. Travis, Karl Smith Byrne, Kay-Tee Khaw, Nicholas J. Wareham, Jonas Manjer, Karin Jirström, Eva Lundin, Annika Idahl, Carmen Navarro, Nerea Etxezarreta, Eva Ardanaz, Maria-Jose Sanchez, Eric J. Duell, Elisabete Weiderpass, Inger Torhild Gram, Petra H. Peeters, N. Charlotte Onland-Moret, H. Bas Bueno-de-Mesquita, Salvatore Panico, Elisabetta Kuhn, Vittorio Krogh, Antonia Trichopoulou, Pagona Lagiou, Vassiliki Benetou, Heiner Boeing, Sabina Rinaldi, Laure Dossus, Gianluca Severi, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Anne Tjønneland, Kim Overvad, Theron Johnson, Allison F. Vitonis, Hidemi S. Yamamoto, Raina N. Fichorova, Anika Hüsing, Renée T. Fortner, Helena Schock, and Kathryn L. Terry

Abstract

Case characteristics (median (min-max) or n (%)) by histologic subtypes in the EPIC cohort

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2023
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295. Supplemental Table S7 from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Author

Brian D. Crompton, Kimberly Stegmaier, Mindy I. Davis, Jason N. Berman, Andrew Kung, Matthew D. Hall, Matthew B. Boxer, Xin Xu, Emma Hughes, Amy Wang, Madeleine E. Lemieux, Gabriela Alexe, Crystal McKnight, Min Shen, Kellsey Wuerthele, Amy Conway Saur, Chansey J. Veinotte, Nicole Melong, Allison F. O'Neill, Rajarshi Guha, Elizabeth E. Hwang, and Sarah Wang

Abstract

Supplemental Table S7. Reverse Phase Protein Array (RPPA) data. Total protein and phosphorylation levels in untreated and treated A673 and TC32 cells are normalized to total protein levels in each sample.

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2023
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296. Supplementary Figure Legends from Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a 64Cu-Labeled Anti-CD99 Antibody

Author

Andrew L. Kung, Alan B. Packard, Antonio R. Perez-Atayde, Monica L. Calicchio, Jon C. Aster, Yanping Sun, Tanya Tupper, Yuchuan Wang, Jason L.J. Dearling, and Allison F. O'Neill

Abstract

PDF file 17K, Supplementary Figure 1: Staining of additional Ewing sarcoma cell lines. All Ewing sarcoma cell lines tested stain equivalently positive for DN16. In all panels, unstained and isotype matched IgG are controls. Supplementary Figure 2: MRI detection of experimental metastases. Experimental liver metastases were induced by IV injection of TC32 cells. Imaging with a 7T MRI demonstrates 1-2 mm metastatic lesions in the liver (white arrows)

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2023
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297. Data from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Ellen L. Goode, Thomas A. Sellers, Brooke L. Fridley, Paul D.P. Pharoah, Catherine M. Phelan, Jennifer Permuth-Wey, Joellen M. Schildkraut, Andrew Berchuck, Argyrios Ziogas, Hannah Yang, Anna H. Wu, Lynne R. Wilkens, Christine Walsh, Allison F. Vitonis, Robert A. Vierkant, David J. van den Berg, Jonathan P. Tyrer, Pamela J. Thompson, Kathryn L. Terry, Honglin Song, Susan J. Ramus, Malcolm C. Pike, Irene Orlow, Kirsten B. Moysich, Francesmary Modugno, Janusz Menkiszak, Jan Lubinski, Jolanta Lissowska, Hui-Yi Lin, Jenny Lester, Sharon E. Johnatty, Allan Jensen, Edwin S. Iversen, Martin Gore, Aleksandra Gentry-Maharaj, Simon A. Gayther, Robert P. Edwards, Ed M. Dicks, Anna deFazio, Cezary Cybulski, Julie M. Cunningham, Michael E. Carney, Louise A. Brinton, Maria Bisogna, Yukie T. Bean, Nicolas Wentzensen, Mary Anne Rossing, Tanja Pejovic, Celeste L. Pearce, Roberta B. Ness, Usha Menon, Douglas A. Levine, Susanne K. Kjaer, Beth Y. Karlan, Jacek Gronwald, Marc T. Goodman, Jennifer A. Doherty, Daniel Cramer, Elisa V. Bandera, Hoda Anton-Culver, Madalene A. Earp, Zachary C. Fogarty, Melissa C. Larson, Yian Ann Chen, Ailith Pirie, and Stacey J. Winham

Abstract

Background: While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variants may be associated with overall EOC survival and assessed their contribution in two exome-based genotyping projects of the Ovarian Cancer Association Consortium (OCAC).Methods: The primary patient set (Set 1) included 14 independent EOC studies (4,293 patients) and 227,892 variants, and a secondary patient set (Set 2) included six additional EOC studies (1,744 patients) and 114,620 variants. Because power to detect rare variants individually is reduced, gene-level tests were conducted. Sets were analyzed separately at individual variants and by gene, and then combined with meta-analyses (73,203 variants and 13,163 genes overlapped).Results: No individual variant reached genome-wide statistical significance. A SNP previously implicated to be associated with EOC risk and, to a lesser extent, survival, rs8170, showed the strongest evidence of association with survival and similar effect size estimates across sets (Pmeta = 1.1E−6, HRSet1 = 1.17, HRSet2 = 1.14). Rare variants in ATG2B, an autophagy gene important for apoptosis, were significantly associated with survival after multiple testing correction (Pmeta = 1.1E−6; Pcorrected = 0.01).Conclusions: Common variant rs8170 and rare variants in ATG2B may be associated with EOC overall survival, although further study is needed.Impact: This study represents the first exome-wide association study of EOC survival to include rare variant analyses, and suggests that complementary single variant and gene-level analyses in large studies are needed to identify rare variants that warrant follow-up study. Cancer Epidemiol Biomarkers Prev; 25(3); 446–54. ©2016 AACR.

Published
2023
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298. Data from Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author

Ellen L. Goode, Julie M. Cunningham, Brooke L. Fridley, Kimberly R. Kalli, Jonathan Tyrer, Honglin Song, Anna deFazio, Sharon E. Johnatty, Jennifer A. Doherty, Catherine M. Phelan, Thomas A. Sellers, Keith L. Knutson, David N. Rider, Starr M. Ramirez, Allison F. Vitonis, Kathryn L. Terry, David Van Den Berg, Malcolm C. Pike, Anna H. Wu, Andrew Berchuck, Aleksandra Gentry-Maharaj, Susan J. Ramus, Simon A. Gayther, Allan Jensen, Janusz Menkiszak, Cezary Cybulski, Jan Lubiński, Argyrios Ziogas, Joseph H. Rothstein, Valerie McGuire, Weiva Sieh, Jenny Lester, Christine S. Walsh, Ignace Vergote, Sandrina Lambrechts, Evelyn Despierre, Montserrat Garcia-Closas, Hannah Yang, Louise A. Brinton, Izabela Ziolkowska-Seta, Iwona K. Rzepecka, Agnieszka Dansonka-Mieszkowska, Ursula Eilber, Anja Rudolph, Lisa E. Paddock, Irene Orlow, Sara H. Olson, Lene Lundvall, Claus K. Hogdall, Ira Schwaab, Andreas du Bois, Philipp Harter, James M. Flanagan, Robert Brown, James Paul, Arif B. Ekici, Matthias W. Beckmann, Alexander Hein, Diana Eccles, Galina Lurie, Laura E. Hays, Yukie T. Bean, Tanja Pejovic, Marc T. Goodman, Ian Campbell, Peter A. Fasching, Stanley B. Kaye, Florian Heitz, Estrid Hogdall, Elisa V. Bandera, Jenny Chang-Claude, Jolanta Kupryjanczyk, Nicolas Wentzensen, Diether Lambrechts, Beth Y. Karlan, Alice S. Whittemore, Hoda Anton Culver, Jacek Gronwald, Douglas A. Levine, Susanne K. Kjaer, Usha Menon, Joellen Schildkraut, Celeste Leigh Pearce, Daniel Cramer, Mary Anne Rossing, Paul D.P. Pharoah, William R. Bamlet, Zachary Fogarty, Robert A. Vierkant, Bridget Charbonneau, and Matthew S. Block

Abstract

Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an important role in many immune and inflammatory responses, including the response to cancer. We studied common inherited variation in 210 genes in the NF-κB family in 10,084 patients with invasive EOC (5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous) from the Ovarian Cancer Association Consortium. Associations between genotype and overall survival were assessed using Cox regression for all patients and by major histology, adjusting for known prognostic factors and correcting for multiple testing (threshold for statistical significance, P < 2.5 × 10−5). Results were statistically significant when assessed for patients of a single histology. Key associations were with caspase recruitment domain family, member 11 (CARD11) rs41324349 in patients with mucinous EOC [HR, 1.82; 95% confidence interval (CI), 1.41–2.35; P = 4.13 × 10−6] and tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) rs7501462 in patients with endometrioid EOC (HR, 0.68; 95% CI, 0.56–0.82; P = 2.33 × 10−5). Other associations of note included TNF receptor–associated factor 2 (TRAF2) rs17250239 in patients with high-grade serous EOC (HR, 0.84; 95% CI, 0.77–0.92; P = 6.49 × 10−5) and phospholipase C, gamma 1 (PLCG1) rs11696662 in patients with clear cell EOC (HR, 0.43; 95% CI, 0.26–0.73; P = 4.56 × 10−4). These associations highlight the potential importance of genes associated with host inflammation and immunity in modulating clinical outcomes in distinct EOC histologies. Cancer Epidemiol Biomarkers Prev; 23(7); 1421–7. ©2014 AACR.

Published
2023
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299. Supplementary Data from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Author

Brian D. Crompton, Kimberly Stegmaier, Mindy I. Davis, Jason N. Berman, Andrew Kung, Matthew D. Hall, Matthew B. Boxer, Xin Xu, Emma Hughes, Amy Wang, Madeleine E. Lemieux, Gabriela Alexe, Crystal McKnight, Min Shen, Kellsey Wuerthele, Amy Conway Saur, Chansey J. Veinotte, Nicole Melong, Allison F. O'Neill, Rajarshi Guha, Elizabeth E. Hwang, and Sarah Wang

Abstract

Supplemental Methods and Figures Supplemental Figure S1. Aurora kinase expression in Ewing sarcoma Supplemental Figure S2. Effects of cell growth on response to AZD-1152 as a function of duration of treatment. Supplemental Figure S3. Aurora kinase and FAK inhibitor combinations are synergistic in Ewing sarcoma cell lines Supplemental Figure S4. Response of Ewing cell lines treated with combinations of Aurora kinase and FAK inhibitors Supplemental Figure S5. Cell cycle and apoptotic effects of Aurora kinase B knock out in Ewing sarcoma cell lines Supplemental Figure S6. PYK2 is poorly expressed in Ewing sarcoma cells Supplemental Figure S7. Zebrafish and Murine studies

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2023
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300. Supplemental Tables from Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Author

Ellen L. Goode, Thomas A. Sellers, Brooke L. Fridley, Paul D.P. Pharoah, Catherine M. Phelan, Jennifer Permuth-Wey, Joellen M. Schildkraut, Andrew Berchuck, Argyrios Ziogas, Hannah Yang, Anna H. Wu, Lynne R. Wilkens, Christine Walsh, Allison F. Vitonis, Robert A. Vierkant, David J. van den Berg, Jonathan P. Tyrer, Pamela J. Thompson, Kathryn L. Terry, Honglin Song, Susan J. Ramus, Malcolm C. Pike, Irene Orlow, Kirsten B. Moysich, Francesmary Modugno, Janusz Menkiszak, Jan Lubinski, Jolanta Lissowska, Hui-Yi Lin, Jenny Lester, Sharon E. Johnatty, Allan Jensen, Edwin S. Iversen, Martin Gore, Aleksandra Gentry-Maharaj, Simon A. Gayther, Robert P. Edwards, Ed M. Dicks, Anna deFazio, Cezary Cybulski, Julie M. Cunningham, Michael E. Carney, Louise A. Brinton, Maria Bisogna, Yukie T. Bean, Nicolas Wentzensen, Mary Anne Rossing, Tanja Pejovic, Celeste L. Pearce, Roberta B. Ness, Usha Menon, Douglas A. Levine, Susanne K. Kjaer, Beth Y. Karlan, Jacek Gronwald, Marc T. Goodman, Jennifer A. Doherty, Daniel Cramer, Elisa V. Bandera, Hoda Anton-Culver, Madalene A. Earp, Zachary C. Fogarty, Melissa C. Larson, Yian Ann Chen, Ailith Pirie, and Stacey J. Winham

Abstract

Supplemental Table S1: Number of invasive EOC patients by study site. Supplemental Table S2: Results of Set 1 single variant analysis, for variants with P

Published
2023
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