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255. Brief-ANT as a tool for measuring the influence of roadside advertisements content on the drivers’ attentional processes

Author

Olejniczak-Serowiec Anna, Maliszewski Norbert, and Harasimczuk Justyna

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

The question of roadside advertisement’s influence on road safety is complex and multi-faceted. The list of advertisements characteristics which may play significant role for road safety includes: the size, colours, shape, luminance, contrast, localization, and many more. One of the aspects is advertisement’s content. Advertising industry uses emotional and cognitive mechanisms which are likely to engage the addressees’ attention and therefore make the brand/product more salient for their minds. As far as such a strategy might be effective for advertisers, it may be dangerous for road safety, when used in roadside advertisement. Cognitive, especially attentional, resources play key role in vehicle driving, which requires constant maintenance of situational awareness. Attention distraction, both visual and cognitive, is a proven safety-decreasing factor in vehicle driving. A method for measuring the influence of different advertisement content on attentional resources management - a short, version of the ANT, Brief-ANT, was developed. The results of a nationwide study conducted, revealed that reaction time in Brief-ANT differed significantly depending on the type of content used as the fixation cue, which leads us to a conclusion that Brief-ANT might be a good measure of the content’s influence on attentional resources management.

Published
2018
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256. (029) INVESTIGATING THE OVERLAPPING PRESENTATION OF IRRITABLE BOWEL SYNDROME AND VULVODYNIA: A SYSTEMATIC REVIEW OF THE EVIDENCE AND MECHANISMS.

Author

Perelmuter, S, Maliszewski, K, and Soogoor, A

Subjects
*IRRITABLE colon, *VULVODYNIA, *DELAYED diagnosis, *OLDER women, *MOLECULAR association
Abstract

Introduction: Vulvodynia is a complex and multifactorial medical condition characterized by pain and discomfort in the vulvar and vaginal area without any identifiable cause. Despite its prevalence, vulvodynia remains underdiagnosed, especially in the United States, leading to delayed diagnosis, increased risk of sexual dysfunction, and reduced quality of life. Concurrently, irritable bowel syndrome (IBS) is a gastrointestinal disorder with a global prevalence predominantly affecting women. Vulvodynia and IBS frequently co-occur in women, with a 2 to 4-fold increased likelihood of IBS diagnosis in those with vulvodynia (1). These comorbid conditions may share common underlying causes, highlighting the need for comprehensive research to better understand the underlying molecule mechanisms and develop effective management strategies. Recognizing the interplay between vulvodynia and IBS is crucial for improving women's health and well-being. Objective: The aim of this review was to assess the evidence and mechanism of simultaneous presentation of IBS and vulvodynia, and whether the incidence of one condition predicts the incidence or increases susceptibility of the other condition. Additionally, this review aims to assess whether treating one condition impacts the presentation, prognosis, or outcome of the other. Methods: A systematic search was conducted in 6 electronic databases: PubMed, Web of Science, Scopus, Science Direct, Google Scholar, and Cochrane Library (publication dates between January 1950 and August 2023). Primary research about the overlap of presentation, diagnosis, or treatment of IBS and vulvodynia was included. Data were extracted from eligible studies, summarized, and collated. Results: Of the 306 unique articles identified, 38 were included in the final analysis: 33 were cross-sectional studies, along with 2 case reports, 1 open-label non-comparative study, 1 cohort study, and 1 nested case-control study. The data represents patients from 21 countries. Common themes amongst the studies included a hypothesis of central hypersensitization which can manifest as either and/or both vulvodynia and IBS, the incidence of vulvodynia being higher in younger and older women (women in their mid-40s had the lowest odds), the significant diagnostic delay in vulvodynia, and the need for a multimodal treatment strategy. Conclusions: Our review adds to the evidence that there is a pervasive association with vulvodynia and IBS. Despite this, research on the underlying molecular mechanisms of the association is scarce, and diagnostic delays persist for vulvodynia. Increasing awareness of the overlap of these conditions will improve screening for vulvodynia in the IBS patient population, therefore improving the diagnostic delay. Further studies over longer time periods, and utilizing randomized study designs are needed to elucidate the mechanism of simultaneous presentation of IBS and vulvodynia, and how we can leverage their pathophysiology clinically to optimize diagnosis and treatment. Disclosure: No. [ABSTRACT FROM AUTHOR]

Published
2024
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259. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in europe. the ACVC-EAPCI EORP STEMI registry of the european society of cardiology

Author

Zeymer, U., Ludman, P., Danchin, N., Kala, P., Laroche, C., Sadeghi, M., Caporale, R., Shaheen, S. M., Legutko, J., Iakobsishvili, Z., Alhabib, K. F., Motovska, Z., Studencan, M., Mimoso, J., Becker, D., Alexopoulos, D., Kereseselidze, Z., Stojkovic, S., Zelveian, P., Goda, A., Mirrakhimov, E., Bajraktari, G., Al-Farhan, H., Serpytis, P., Raungaard, B., Marandi, T., Moore, A. M., Quinn, M., Karjalainen, P. P., Tatu-Chitolu, G., Gale, C. P., Maggioni, A. P., Weidinger, F., Sinnaeve, P., Ferrari, R., Karamfilov, K., Lidon, R. -M., Kereselidze, Z., Iakobishvili, Z., Erglis, A., Kedev, S., Dudek, D., Tatu-Chitoiu, G., Shlyakhto, E., Bunc, M., Mourali, M. S., Konte, M., Larras, F., Lefrancq, E. F., Mekhaldi, S., Shuka, N., Pavli, E., Tafaj, E., Gishto, T., Dibra, A., Duka, A., Gjana, A., Kristo, A., Knuti, G., Demiraj, A., Dado, E., Hasimi, E., Simoni, L., Siqeca, M., Sisakian, H., Hayrapetyan, H., Markosyan, S., Galustyan, L., Arustamyan, N., Kzhdryan, H., Pepoyan, S., Zirkik, A., Von Lewinski, D., Paetzold, S., Kienzl, I., Matyas, K., Neunteufl, T., Nikfardjam, M., Neuhold, U., Mihalcz, A., Glaser, F., Steinwender, C., Reiter, C., Grund, M., Hrncic, D., Hoppe, U., Hammerer, M., Hinterbuchner, L., Hengstenberg, C., Delle Karth, G., Lang, I., Winkler, W., Hasun, M., Kastner, J., Havel, C., Derntl, M., Oberegger, G., Hajos, J., Adlbrecht, C., Publig, T., Leitgeb, M. -C., Wilfing, R., Jirak, P., C. -Y., Ho, Puskas, L., Schrutka, L., Spinar, J., Parenica, J., Hlinomaz, O., Fendrychova, V., Semenka, J., Sikora, J., Sitar, J., Groch, L., Rezek, M., Novak, M., Kramarikova, P., Stasek, J., Dusek, J., Zdrahal, P., Polasek, R., Karasek, J., Seiner, J., Sukova, N., Varvarovsky, I., Lazarak, T., Novotny, V., Matejka, J., Rokyta, R., Volovar, S., Belohlavek, J., Siranec, M., Kamenik, M., Kralik, R., Ravkilde, J., Jensen, S. E., Villadsen, A., Villefrance, K., Schmidt Skov, C., Maeng, M., Moeller, K., Hasan-Ali, H., Ahmed, T. A., Hassan, M., Elguindy, A., Farouk Ismail, M., Ibrahim Abd El-Aal, A., El-Sayed Gaafar, A., Magdy Hassan, H., Ahmed Shafie, M., Nabil El-Khouly, M., Bendary, A., Darwish, M., Ahmed, Y., Amin, O. A., Abdelhakim, A., Abosaif, K., Kandil, H., Galal, M. A. G., El Hefny, E. E., El Sayed, M., Aly, K., Mokarrab, M., Osman, M., Abdelhamid, M., Mantawy, S., Ali, M. R., Kaky, S. D., Khalil, V. A., Saraya, M. E. A., Talaat, A., Nabil, M., Mounir, W. M., Mahmoud, K., Aransa, A., Kazamel, G., Anwar, S., Al-Habbaa, A., Abd El Monem, M., Ismael, A., Amin Abu-Sheaishaa, M., Abd Rabou, M. M., Hammouda, T. M. A., Moaaz, M., Elkhashab, K., Ragab, T., Rashwan, A., Rmdan, A., Abdelrazek, G., Ebeid, H., Soliman Ghareeb, H., Farag, N., Zaki, M., Seleem, M., Torki, A., Youssef, M., Allah Nasser, N. A., Rafaat, A., Selim, H., Makram, M. M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. P., Papadopoulos, C., Tzikas, S., Vogiatzis, I., Datsios, A., Galitsianos, I., Koutsampasopoulos, K., Grigoriadis, S., Douras, A., Baka, N., Spathis, S., Kyrlidis, T., Hatzinikolaou, H., Kiss, R. G., Nowotta, F., Toth, K., Szabo, S., Lakatos, C., Jambrik, Z., Ruzsa, J., Ruzsa, Z., Rona, S., Toth, J., Vargane Kosik, A., Toth, K. S. B., Nagy, G. G., Ondrejko, Z., Koromi, Z., Botos, B., Pourmoghadas, M., Salehi, A., Massoumi, G., Soleimani, A., Sarrafzadegan, N., Roohafza, H., Azarm, M., Mirmohammadsadeghi, A., Rajabi, D., Rahmani, Y., Siabani, S., Najafi, F., Hamzeh, B., Karim, H., Siabani, H., Saleh, N., Charehjoo, H., Zamzam, L., Al-Temimi, G., Al-Yassin, A., Mohammad, A., Ridha, A., Al-Saedi, G., Atabi, N., Sabbar, O., Mahmood, S., Dakhil, Z., Yaseen, I. F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, Giuseppe, Andò, Giuseppe, Carerj, Scipione, Saporito, Francesco, Cimmino, Michele, Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. M., Sedky, E., Alsihati, Z., Mimish, L., Selem, A., Malik, A., Majeed, O., Altnji, I., Alshehri, M., Aref, A., Alhabib, K., Aldosary, M., Tayel, S., Abd Alrahman, M., Asfina, K. N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. M., Gonzalez-Cambeiro, C., Gonzalez-Babarro, E., Domingo-Del Valle, J., Royuela, N., Burgos, V., Canteli, A., Castrillo, C., Cobo, M., Ruiz, M., Abu-Assi, E., Garcia Acuna, J., Zeymer, U., Ludman, P., Danchin, N., Kala, P., Laroche, C., Sadeghi, M., Caporale, R., Shaheen, S. M., Legutko, J., Iakobsishvili, Z., Alhabib, K. F., Motovska, Z., Studencan, M., Mimoso, J., Becker, D., Alexopoulos, D., Kereseselidze, Z., Stojkovic, S., Zelveian, P., Goda, A., Mirrakhimov, E., Bajraktari, G., Al-Farhan, H., Serpytis, P., Raungaard, B., Marandi, T., Moore, A. M., Quinn, M., Karjalainen, P. P., Tatu-Chitolu, G., Gale, C. P., Maggioni, A. P., Weidinger, F., Sinnaeve, P., Ferrari, R., Karamfilov, K., Lidon, R. -M., Kereselidze, Z., Iakobishvili, Z., Erglis, A., Kedev, S., Dudek, D., Tatu-Chitoiu, G., Shlyakhto, E., Bunc, M., Mourali, M. S., Konte, M., Larras, F., Lefrancq, E. F., Mekhaldi, S., Shuka, N., Pavli, E., Tafaj, E., Gishto, T., Dibra, A., Duka, A., Gjana, A., Kristo, A., Knuti, G., Demiraj, A., Dado, E., Hasimi, E., Simoni, L., Siqeca, M., Sisakian, H., Hayrapetyan, H., Markosyan, S., Galustyan, L., Arustamyan, N., Kzhdryan, H., Pepoyan, S., Zirkik, A., Von Lewinski, D., Paetzold, S., Kienzl, I., Matyas, K., Neunteufl, T., Nikfardjam, M., Neuhold, U., Mihalcz, A., Glaser, F., Steinwender, C., Reiter, C., Grund, M., Hrncic, D., Hoppe, U., Hammerer, M., Hinterbuchner, L., Hengstenberg, C., Delle Karth, G., Lang, I., Winkler, W., Hasun, M., Kastner, J., Havel, C., Derntl, M., Oberegger, G., Hajos, J., Adlbrecht, C., Publig, T., Leitgeb, M. -C., Wilfing, R., Jirak, P., Ho, C. -Y., Puskas, L., Schrutka, L., Spinar, J., Parenica, J., Hlinomaz, O., Fendrychova, V., Semenka, J., Sikora, J., Sitar, J., Groch, L., Rezek, M., Novak, M., Kramarikova, P., Stasek, J., Dusek, J., Zdrahal, P., Polasek, R., Karasek, J., Seiner, J., Sukova, N., Varvarovsky, I., Lazarak, T., Novotny, V., Matejka, J., Rokyta, R., Volovar, S., Belohlavek, J., Siranec, M., Kamenik, M., Kralik, R., Ravkilde, J., Jensen, S. E., Villadsen, A., Villefrance, K., Schmidt Skov, C., Maeng, M., Moeller, K., Hasan-Ali, H., Ahmed, T. A., Hassan, M., Elguindy, A., Farouk Ismail, M., Ibrahim Abd El-Aal, A., El-Sayed Gaafar, A., Magdy Hassan, H., Ahmed Shafie, M., Nabil El-Khouly, M., Bendary, A., Darwish, M., Ahmed, Y., Amin, O. A., Abdelhakim, A., Abosaif, K., Kandil, H., Galal, M. A. G., El Hefny, E. E., El Sayed, M., Aly, K., Mokarrab, M., Osman, M., Abdelhamid, M., Mantawy, S., Ali, M. R., Kaky, S. D., Khalil, V. A., Saraya, M. E. A., Talaat, A., Nabil, M., Mounir, W. M., Mahmoud, K., Aransa, A., Kazamel, G., Anwar, S., Al-Habbaa, A., Abd El Monem, M., Ismael, A., Amin Abu-Sheaishaa, M., Abd Rabou, M. M., Hammouda, T. M. A., Moaaz, M., Elkhashab, K., Ragab, T., Rashwan, A., Rmdan, A., Abdelrazek, G., Ebeid, H., Soliman Ghareeb, H., Farag, N., Zaki, M., Seleem, M., Torki, A., Youssef, M., Allah Nasser, N. A., Rafaat, A., Selim, H., Makram, M. M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. P., Papadopoulos, C., Tzikas, S., Vogiatzis, I., Datsios, A., Galitsianos, I., Koutsampasopoulos, K., Grigoriadis, S., Douras, A., Baka, N., Spathis, S., Kyrlidis, T., Hatzinikolaou, H., Kiss, R. G., Nowotta, F., Toth, K., Szabo, S., Lakatos, C., Jambrik, Z., Ruzsa, J., Ruzsa, Z., Rona, S., Toth, J., Vargane Kosik, A., Toth, K. S. B., Nagy, G. G., Ondrejko, Z., Koromi, Z., Botos, B., Pourmoghadas, M., Salehi, A., Massoumi, G., Soleimani, A., Sarrafzadegan, N., Roohafza, H., Azarm, M., Mirmohammadsadeghi, A., Rajabi, D., Rahmani, Y., Siabani, S., Najafi, F., Hamzeh, B., Karim, H., Siabani, H., Saleh, N., Charehjoo, H., Zamzam, L., Al-Temimi, G., Al-Yassin, A., Mohammad, A., Ridha, A., Al-Saedi, G., Atabi, N., Sabbar, O., Mahmood, S., Dakhil, Z., Yaseen, I. F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, G., Ando, G., Carerj, S., Saporito, F., Cimmino, M., Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. M., Sedky, E., Alsihati, Z., Mimish, L., Selem, A., Malik, A., Majeed, O., Altnji, I., Alshehri, M., Aref, A., Alhabib, K., Aldosary, M., Tayel, S., Abd Alrahman, M., Asfina, K. N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. M., Gonzalez-Cambeiro, C., Gonzalez-Babarro, E., Domingo-Del Valle, J., Royuela, N., Burgos, V., Canteli, A., Castrillo, C., Cobo, M., Ruiz, M., Abu-Assi, E., and Garcia Acuna, J.

Subjects
Registrie, medicine.medical_specialty, medicine.medical_treatment, Cardiology, Myocardial Reperfusion, 030204 cardiovascular system & hematology, 03 medical and health sciences, Hospital, 0302 clinical medicine, Reperfusion therapy, Percutaneous Coronary Intervention, Internal medicine, Fibrinolysis, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Registries, Prospective Studies, Prospective cohort study, Observational studies, observational studies, reperfusion therapy, business.industry, Mortality rate, Primary percutaneous coronary intervention, ST-elevation myocardial infarction, Europe, Hospitals, Treatment Outcome, ST Elevation Myocardial Infarction, Percutaneous coronary intervention, medicine.disease, primary percutaneous coronary intervention, Observational studie, 3. Good health, Prospective Studie, Cohort, Conventional PCI, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims The aim of this study was to determine the contemporary use of reperfusion therapy in the European Society of Cardiology (ESC) member and affiliated countries and adherence to ESC clinical practice guidelines in patients with ST-elevation myocardial infarction (STEMI). Methods and results Prospective cohort (EURObservational Research Programme STEMI Registry) of hospitalized STEMI patients with symptom onset Conclusions The use of reperfusion therapy for STEMI in the ESC member and affiliated countries was high. Primary PCI was the most frequently used treatment and associated total in-hospital mortality was below 5%. However, there was geographic variation in the use of primary PCI, which was associated with differences in in-hospital mortality.

Published
2021
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260. Nawiedzanie słów, turbulencja i sekret edukacji. Czytając Adolphe’a Gesche’a

Author

Krzysztof Maliszewski

Subjects
Education
Abstract

The Belgian theologian, the philosopher and the specialist in literature Adolphe Gesche (1928–2003) writes that it is necessary to frequent old words. He interprets traditional terms of the Christian message (e.g. the salvation, the eternity, the resurrection) and tries to wake them up, to make them clear, accessible to the contemporary sensitivity. One isn’t allowed to close the Christian address in the exclusive range of the confessio, it is an essential part of the contemporary culture. Adolphe Gesche is leading out the category of salvation from the more and more poorly understood religious idiom to wide waters of the humanistic discourse. A question about the salvation is one of the crucial human questions, and it is arising from longing for the secret of living above all, rather than from the fear and feeling the fault only. The revival of meanings in the Adolphe Gesche’s work shows the Christianity vital, dynamic, feeding on the affirmation of the freedom and the life, but not on resentment to the present time. Gesche doesn’t prove the existence of God and the eternal life. He is only persuading not to leave former questions and old replies rashly. Theology is a turbulence in the science. The faith is a means of conveying the powerful, peculiar discourse upon the man. It is setting the anthropological reflection in motion. In the theological perspective the man is a riddle, something elusive and incomprehensible stays inside him. The education has the important task: to help the man to raise his oddness, mystery, non-transparency, strangeness, without escaping into a simple and a seeming answers. Gesche’s achievements is an example of the opened, modern recognition which doesn’t fear the meetings – but it is drawing the power from the joints and tensions. Paedagogia_

Published
2009
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268. MOCCA-SURVEY Database II -- Properties of Intermediate Mass Black Holes escaping from star clusters

Author

Konrad Maliszewski, Mirek Giersz, Dorota Gondek-Rosinska, Abbas Askar, and Arkadiusz Hypki

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics::Galaxy Astrophysics
Abstract

In this work we investigate properties of intermediate-mass black holes (IMBHs) that escape from star clusters due to dynamical interactions. The studied models were simulated as part of the preliminary second survey carried out using the MOCCA code (MOCCA-SURVEY Database II), which is based on the Monte Carlo N-body method and does not include gravitational wave recoil kick prescriptions of the binary black hole merger product. We have found that IMBHs are more likely to be formed and ejected in models where both initial central density and central escape velocities have high values. Most of our studied objects escape in a binary with another black hole (BH) as their companion and have masses between $100$ and $140\: M_{\odot}$. Escaping IMBHs tend to build-up mass most effectively through repeated mergers in a binary with BHs due to gravitational wave emission. Binaries play a key role in their ejection from the system as they allow these massive objects to gather energy needed for escape. The binaries in which IMBHs escape tend to have very high binding energy at the time of escape and the last interaction is strong but does not involve a massive intruder. These IMBHs gain energy needed to escape the cluster gradually in successive dynamical interactions. We present specific examples of the history of IMBH formation and escape from star cluster models. We also discuss the observational implications of our findings as well as the potential influence of the gravitational wave recoil kicks on the process., 11 pages, 11 figures, accepted for publish to MNRAS

Published
2021

269. Novel wing display and divergent agonistic behaviors of two incipient Psolodesmus damselflies

Author

Leocris S. Batucan, Yu Hsun Hsu, Jak W. Maliszewski, Chung Ping Lin, and Liang-Jong Wang

Subjects
education.field_of_study, animal structures, Wing, Psolodesmus mandarinus, Population, Zoology, General Medicine, Biology, biology.organism_classification, Odonata, White (mutation), Calopterygidae, Sexual selection, Agonistic behaviour, education, Ecology, Evolution, Behavior and Systematics
Abstract

Sexual selection via male competition is a strong evolutionary force that can drive rapid changes in competitive traits and subsequently lead to population divergence and speciation. Territorial males of many odonates are known to use their colorful wings as visual signals and to perform agonistic displays toward intruders. Psolodesmus mandarinus dorothea and Psolodesmus mandarinus mandarinus are two parapatrically distributed sister damselflies that share similar ecological characteristics but differ markedly in wing coloration. The wings of P. m. dorothea are mostly clear, whereas those of P. m. mandarinus have a large area of black pigmentation and a central white patch. We investigated whether territorial males of the two damselflies at breeding sites display distinct agonistic behaviors associated with their respective wing colors. Behavioral interactions between territorial and intruder males and their wing kinematics were filmed and analyzed for P. m. dorothea in Lienhuachih of central Taiwan, and P. m. mandarinus in Tianxiyuan and Fusan of northern Taiwan. We observed that the P. m. mandarinus males exhibited a novel set of perched wing displays, which was not only absent in its sister P. m. dorothea but also previously unknown in Odonata. At breeding sites, perched rival males of P. m. mandarinus with pigmented wings exhibited escalating agonistic wing-flapping and wing-hitting displays toward each other. In contrast, territorial males of P. m. dorothea with clear wings engaged only in aerial chase or face-to-face hovering when intruder males approached from the air. These results indicate that the two sister P. mandarinus damselflies diverged behaviorally in territorial contests and support the hypothesis of coadaptation on the basis of wing colors and types of wing movement in Odonata. Our findings further suggest that divergent agonistic wing displays may play a pivotal role in the speciation mechanism of P. mandarinus damselflies. The sequential analyses of behavioral characteristics and progression suggest that P. m. mandarinus damselflies likely use mutual assessment of rivals in territorial contests.

Published
2021
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270. Incidence of mechanical complications following myocardial infarction during the first two months of the COVID-19 pandemic in the Southern Poland region: a multicenter study

Author

Jerzy Matysek, Maciej Maliszewski, Grzegorz Filip, Łukasz Rzeszutko, Krzysztof Bartuś, Jacek Godlewski, Bogusław Kapelak, Andrzej Wiśniewski, Radosław Litwinowicz, Jarosław Blicharz, Magdalena Bryndza, Paweł Kocik, Łukasz Wiśniowski, Marcin Nosal, Anna Orzechowska, Artur Klecha, Jacek Legutko, Stanisław Bartuś, and Renata Korpak-Wysocka

Subjects
Adult, Male, 2019-20 coronavirus outbreak, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pandemic, medicine, Humans, Myocardial infarction, Pandemics, Aged, Aged, 80 and over, SARS-CoV-2, business.industry, Incidence, Incidence (epidemiology), Follow up studies, COVID-19, Middle Aged, medicine.disease, Respiration, Artificial, Multicenter study, ST Elevation Myocardial Infarction, Female, Poland, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, Forecasting
Published
2021
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275. Application of FT-IR technique to bituminous materials

Author

Adam Zofka, Dominika Maliszewska, and Maciej Maliszewski

Subjects
spectroscopy, electromagnetic spectrum, infrared, FT-IR, aging, bitumen, Architecture, NA1-9428, Engineering (General). Civil engineering (General), TA1-2040, Industrial engineering. Management engineering, T55.4-60.8
Abstract

Spectroscopy is a fundamental method used in the material science that relies on the interaction of the electromagnetic radiation with a matter. Infrared spectroscopy allows for material fingerprinting as well as detection and quantification of compounds in a sample. In principle, IR spectrometers record the absorption of electromagnetic energy by chemical bounds in a sample as a function of wavelength. Chemical bounds have unique spectra bands at specific wavelengths regardless of the composition of the remaining molecular structure. The absorbance at these specific wavelengths can be used to quantify a particular functional group in the analyzed material. Absorbance peaks are easily identified on the IR spectra and can be used to fingerprint a compound in a mixture, especially when compared to the original unmodified IR spectra. In the recent years, the FT-IR method has become a popular tool for the quality assurance in the practical applications as well as it became a very useful tool in studying various construction materials, e.g. portland cement, bitumen, etc.

Published
2014
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279. Platinum-Catalyzed Alkene Hydrosilylation: Solvent-Free Process Development from Batch to a Membrane-Integrated Continuous Process

Author

Dominic Ormerod, Tahani Al Chami Al Bayrakdar, Steven P. Nolan, Fady Nahra, and Benon P. Maliszewski

Subjects
chemistry.chemical_classification, Chemistry, Hydrosilylation, Alkene, General Chemical Engineering, chemistry.chemical_element, Homogeneous catalysis, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, General Energy, Membrane, Imidazolidine, Yield (chemistry), Environmental Chemistry, General Materials Science, Platinum
Abstract

The integration of a membrane separation protocol with the platinum-catalyzed hydrosilylation of olefins is investigated. The catalytic reaction is first optimized in batch where [Pt(IPr*)(dms)Cl2 ] (IPr*=1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazol-2-ylidene, dms=dimethyl sulfide) demonstrates superior activity compared to the less sterically encumbered [Pt(SIPr)(dms)Cl2 ] (SIPr=1,3-bis(2,6-diisopropylphenyl)imidazolidine) congener. Filtration conditions are identified in membrane screening experiments. Hydrosilylation of 1-octene catalyzed by [Pt(IPr*)(dms)Cl2 ] is conducted in continuous mode and the platinum catalyst is separated efficiently over the commercially available Borsig oNF-2 membrane, all under solvent-free conditions. An advantage of this process is that both reaction and separation are coupled in a single step. Moreover, at the end of the process the intact catalyst was recovered in 80 % yield as an off-white solid without any further purification.

Published
2021

280. 1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors

Author

Agnieszka Wróbel, Beata Kolesinska, Justyna Frączyk, Danuta Drozdowska, and Dawid Maliszewski

Subjects
Aché, Stereochemistry, Pharmaceutical Science, Peptide, GPI-Linked Proteins, 01 natural sciences, Analytical Chemistry, β-secretase, 03 medical and health sciences, chemistry.chemical_compound, QD241-441, 1,3,5-Triazine, 1,3,5-triazine, Drug Discovery, mental disorders, Aspartic Acid Endopeptidases, Humans, Physical and Theoretical Chemistry, IC50, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Dipeptide, 010405 organic chemistry, Triazines, Communication, Organic Chemistry, acetylcholinesterase, Acetylcholinesterase, language.human_language, 0104 chemical sciences, nitrogen mustards, Enzyme, Förster resonance energy transfer, chemistry, Chemistry (miscellaneous), Nitrogen Mustard Compounds, language, Molecular Medicine, Cholinesterase Inhibitors, Amyloid Precursor Protein Secretases, Peptides
Abstract

A series of new analogs of nitrogen mustards (4a–4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and β-secretase (BACE1) enzymes. The AChE inhibitory activity studies were carried out using Ellman’s colorimetric method, and the BACE1 inhibitory activity studies were carried out using fluorescence resonance energy transfer (FRET). All compounds displayed considerable AChE and BACE1 inhibition. The most active against both AChE and BACE1 enzymes were compounds A and 4a, with an inhibitory concentration of AChE IC50 = 0.051 µM; 0.055 µM and BACE1 IC50 = 9.00 µM; 11.09 µM, respectively.

Published
2021

295. Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

Author

Danuta Drozdowska, Dawid Maliszewski, Agnieszka Wróbel, and Karolina Arciszewska

Subjects
0301 basic medicine, medicine.drug_class, 030106 microbiology, Antibiotics, Review Article, 01 natural sciences, Trimethoprim, 03 medical and health sciences, Antibiotic resistance, Drug Development, Drug Discovery, Dihydrofolate reductase, medicine, Humans, heterocyclic compounds, Pharmacology, chemistry.chemical_classification, biology, 010405 organic chemistry, Drug discovery, Antimicrobial, Dihydrofolate reductase inhibitor, Anti-Bacterial Agents, 0104 chemical sciences, Tetrahydrofolate Dehydrogenase, Enzyme, chemistry, Biochemistry, Drug Design, biology.protein, Folic Acid Antagonists, medicine.drug
Abstract

The development of new mechanisms of resistance among pathogens, the occurrence and transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases have been a serious clinical problem around the world for over 50 years. Therefore, intense searching of new leading structures and active substances, which may be used as new drugs, especially against strain resistant to all available therapeutics, is very important. Dihydrofolate reductase (DHFR) has attracted a lot of attention as a molecular target for bacterial resistance over several decades, resulting in a number of useful agents. Trimethoprim (TMP), (2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine) is the well-known dihydrofolate reductase inhibitor and one of the standard antibiotics used in urinary tract infections (UTIs). This review highlights advances in design, synthesis, and biological evaluations in structural modifications of TMP as DHFR inhibitors. In addition, this report presents the differences in the active site of human and pathogen DHFR. Moreover, an excellent review of DHFR inhibition and their relevance to antimicrobial and parasitic chemotherapy was presented.

Published
2019
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296. Facilitating Transfer Student Success: Exploring Sources of Transfer Student Capital

Author

Casey Maliszewski Lukszo and Shannon Hayes

Subjects
Self-efficacy, business.industry, Capital (economics), ComputingMilieux_COMPUTERSANDEDUCATION, Peer influence, Public relations, Community college, business, Education, Social capital
Abstract

Objective: This study seeks to expand understanding of transfer student capital (TSC), including sources of TSC and how TSC is used by community college transfer students to navigate transfer to a public, 4-year institution. Method: Using the TSC framework, a descriptive case study design was employed. Data sources include 17 transfer student interviews, eight observations of pre-transfer meetings between students and advisors, and a review of documents. Data were analyzed inductively and deductively using a pattern matching coding technique. Results: Family and peers appear to be the most common way that students gain TSC to navigate the transfer process. High schools also provide critical transfer information to students. Transfer advisors and faculty either at community colleges or 4-year colleges sometimes provide important transfer information but serve in a critical role of building students’ self-efficacy for transfer rather than merely passing along transfer information. Contributions: This study indicates that high schools, family members, and peers are influential sources of TSC, in addition to previously well-understood sources, such as community college faculty and transfer advisors. This study introduces a new term, self-efficacy for transfer, and offers an expanded TSC conceptual model.

Published
2019
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297. 'So that finally it is all about life in poetry'. Lyrics by Bogusław Kierc

Author

Karol Maliszewski

Subjects
Literature, Transcendence (philosophy), Poetry, business.industry, media_common.quotation_subject, Musical, Art, Lyrics, Originality, Spirituality, HERO, business, Mysticism, media_common
Abstract

‘So that finally it is all about life in poetry’. Lyrics by Boguslaw Kierc The author of this article analyzes the poetry of Boguslaw Kierc, a poet from Wroclaw, pointing to the separateness and originality of this artist. Originality is revealed in risky and bold themes and a form that is a combination of something avant-garde with something very traditional. The language used by the poet, concerning ultimate and mystical problems, captivates with harmonious, musical finesse. Pictures in this poetry are seen, heard and experienced. The hero of these poems sees in his somatic and erotic experiences the source of potential mysticism, the possibility of approaching transcendence.

Published
2019
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299. Synthesis of the non-adjacent bis(tetrahydrofuran) core of squamostanin C by silicon-tethered, size-selective triple ring-closing metathesis

Author

Justin H. Markowski, Patrick J. Miller, Kevin J. Quinn, Yun Hu, Michaella A. Caporello, Ryan T. Walsh, and Mary L. Maliszewski

Subjects
Silicon, 010405 organic chemistry, Chemistry, Organic Chemistry, chemistry.chemical_element, Core (manufacturing), One-Step, 010402 general chemistry, Metathesis, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, Ring-closing metathesis, Yield (chemistry), Drug Discovery, Polymer chemistry, Stereoselectivity, Tetrahydrofuran
Abstract

Synthesis of the C2-symmetric, non-adjacent bis(tetrahydrofuran) core of squamostanin C in seven steps and 24% overall yield from (R,R)-1,5-hexadiene-3,4-diol is reported. Silicon-tethered, size-selective triple ring-closing metathesis of an acyclic hexaene is employed for assembly of the central 1,4-diol unit and concurrent chain extension via lactone formation. Stereoselective construction of both tetrahydrofuran rings is achieved in one step through the use of two-directional Mukaiyama aerobic alkenol cyclization.

Published
2019
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300. Rola dialogu w procesie wychowawczym – ujęcie filozoficzne i pedagogiczne

Author

Rafał Maliszewski

Abstract

This article shows the dialog as an important aspect of the upbringing process, which leads individuals to discover both themselves and the reality from the perspective of truth. The dialog which is inspired by the Socrates tradition and the dialog philosophy is a key element of the dialog pedagogy, in which particular attitudes influence upon the development of interpersonal relationships. The article aims at showing the school as a place where an educator meets a student and where love and justice, leading to a complete development of a human being as a physical-psychological-spiritual being, are developed.

Published
2019
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