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A complex of research has been conducted to establish the causes of the accident of the main gas pipeline made of 1420x15.7 mm X70 steel after 20 years of operation. It is found that pipe destruction was initiated by the longitudinal crack with a length of 470 mm and a maximum depth of 6.8 mm, oriented in the direction of the pipe and perpendicular to the outer surface of the pipe identified as stress-corrosion cracking. The crack initiation is due to the disboundment of the tape protection coating, the high corrosion activity of the soil, and the complex stress-strain state caused by deviations from the design objectives during construction. The chemical composition the base metal of all investigated pipes corresponds to the requirements of the technical conditions for steel pipes in category X70; pipes welding are performed with the typical materials used in pipe welding plants. Despite the differences, the structural and mechanical characteristics (yield strength, ultimate strength, and impact strength) of the steel and weld metal of the studied pipes are identical. The relative elongation (d5) of the operated pipes is below the normalized values, but, it is necessary to take into account the possibility of deviations in these characteristics of steel in the initial state. Significant reserves of toughness indirectly indicate low damage of metal and, accordingly, satisfactory resistance to destruction of the metal of the studied pipes.

The purpose of the study: to establish the clinical and prognostic value of fibronectin and circulating immune complexes of blood in children with viral meningitis, depending on the period, severity, course and outcome of the disease. Material and methods.The concentration of plasma fibronectin and the total amount of circulating immune complexes were determined by enzyme immunoassay in 167 children of patients with viral meningitis of various etiologies. The etiology of meningitis was confirmed by positive results of the PCR reaction and by enzyme immunoassay. The biological material for the study was: cerebrospinal fluid and/or blood. Results: In the acute period of moderate-severity viral meningitis, the concentration of fibronectin decreased and found.

BACKGROUND. Hormonal dependence of ovarian cancer remains a debatable issue in modern oncogynecology. Its decision will allow not only to clarify the pathogenesis of the development of ovarian cancer, its prognosis, but also to substantiate the indications for hormone therapy as a component of complex treatment. OBJECTIVE. To study the experience of domestic and foreign specialists regarding the pathogenetic rationale for prescribing hormone therapy to patients with ovarian cancer and its effectiveness. MATERIALS AND METHODS. Generalization and analysis of scientific publications on the research topic. RESULTS. The article summarizes data on the pathogenetic rationale for the appointment of hormone therapy, as well as the effectiveness of antiestrogens and aromatase inhibitors in the treatment of primary ovarian cancer and recurrences of the disease. CONCLUSIONS. To date, indications for the appointment and criteria for the use of hormone therapy in the complex treatment of ovarian cancer are not developed. The question of the reliability of the factors of the disease prognosis, taking into account the hormonal receptor status of ovarian cancer, remains open.

The article analyses the functioning of the war-time Ukrainian humorous discourse in media communication in general and the cognitive mechanisms of humor, including the ‘Availability Heuristic’ cognitive pattern in particular.’ The study aims to examine twelve Ukrainian war-time jokes and to reveal the main cognitive patterns and accompanying stylistic figures producing the comic effect. All jokes manifest the application of the ‘Availability heuristic’ cognitive pattern inherent to the war period when old pre-war realities are changed with new war-time realities and explained in a funny way. The study addresses some cognitive and pragmatic aspects of war-time Ukrainian humor, focusing on the role of cognitive patterns in selecting stylistic humor devices while processing the incoming information and shaping the cognitive frameworks of humor perception and creation. The paper reveals the main cognitive patterns, including the ‘Availability Heuristic,’ the ‘Distinct contrast,’ ‘Negativity Thinking,’ the ‘Superiority or Illusionary Superiority,’ the ‘Easel,’ and their humorous actualization through such stylistic figures as paraprosdokian, irony, bathos, double entendre, pun, metaphor and pastiche in its narrow meaning. The researched Ukrainian jokes are interwoven with the situational context of the dramatic events within the temporality of the speedy streaming news of the Russian-Ukrainian war. The paper explores the main pragmatic functions of Ukrainian war-time humorous discourse and makes additional remarks about a number of affirmations from some humor theories. The war-time Ukrainian humorous discourse is set against the background of the current cruel Russian-Ukrainian war realities. It differs from the pre-war Ukrainian humorous discourse stylistically, pragmatically, and cognitively.

The article aims to describe the technique of schematic visualization of the client's emotional sphere, which is developed for use in group psychotherapy and is aimed at increasing the level of the client's reflexivity by increasing the quality of the process of reflection in this sphere. For productive work with the client in most psychotherapeutic methods, especially the humanistic paradigm, one of the important factors is such a property of the client's personality as the possibility of the existence of the process of self-knowledge, i.e. the client's reflexivity, but it is not always developed to a level sufficient for psychotherapeutic work (in this case, "reflexivity” is used as a broader concept than “reflection”). To solve this issue, it is necessary to develop new techniques, which is proposed by the author of the work. The use of this technique contributes to increasing the ability to manifest one's own emotions and feelings and to the client's visual demonstration and awareness of the features of the structure of his emotional sphere and formations in it, which are characteristic of persons with traumatic emotional experience. For example: "gluing" of emotions of asthenic and sthenic circles; destructive connotation of positive emotions with negative ones; inability to feel "pure" emotion; the phenomenon of potentiation of negative emotionality; loss of resourcefulness of certain emotions, which are contaminated by other emotions; the existence of "through" emotions, which become core characteristics of the emotional sphere of the individual. During the application of the technique, the work is structured in such a way as to maximally involve the dynamics of the group, emotional, cognitive and behavioral levels to increase the quality of reflection of the emotional sphere and the client's reflexivity as a whole. The classification of reflexivity is used for the analytical part in the application of the technique (for example, the comparison of emotional manifestations characteristic of the client in retrospective, prospective and situational vectors), and the idea of "surreality" at the stage of transformation and modeling. In this work, 9 stages of technique application are provided in detail and the role and tasks of the psychotherapist, client and group members at each of them are described.

The review is devoted to the nutritional significance and prospects of garden rhubarb (Rheum rhabarbarum L.) utilization in food industry. High yield of juice reaching 90% and the ability to complex rhubarb stems processing for juice production and pectin extraction from rhubarb stem pomace are empathized. Rhubarb stems pomace recorded up to 21-23 % of pectin, which is significantly higher than in natural industrial sources of pectin. Medicinal value of rhubarb juice is discussed: antioxidant, anti-inflammatory, anti-carcinogenic, cardioprotective and anti-diabetic properties are indicated. Examples of high antioxidant content and unique organic acids composition of rhubarb juice are highlighted. Sorbic and benzoic acids are indicated as important components of juice widely used in food industry as food preservatives. Citric acid is shown to be the main component of rhubarb organic acids in spring. Special attention is paid to the non-waste production of juice thanks to the possibility of pomace processing for pectin recovery. Juice biochemical characteristics of four garden rhubarb cultivars (selection of Federal Scientific Center of Vegetable Production) are described: Udalets, Malakhit, Zaryanka and Krupnochereshkovy). Expediency of further selection on high anthocyanin content in rhubarb stems are empathized.

Epizootiological monitoring studies on parasitoses of domestic ruminants indicate that one of the most common causes of nematodes of the digestive tract in large and small cattle are helminths of the genus Trichuris. Those helminths develop directly – without intermediate hosts, and their embryonic stages became invasive in the environment under favorable conditions. The eggs of those parasites are incredibly resistant and can be infective for a long time contaminating environmental objects. So, to improve the parasitological situation in livestock farms, we have to look for the most effective methods of disinfestation of environmental objects. This study aimed to establish the ovicidal effect of the modern disinfectant “Arquadez-plus” on eggs of nematodes Trichuris skrjabini parasitizing sheep. This product's high level of ovicidal efficiency was seen in experimental cultures of nematodes' eggs at 1.5 % concentration and 60 min exposure (94.2 %) and 2.0 % concentration and 10–60 min exposure (98.3–100.0 %). The ovicidal effect of “Arquadez-plus” on eggs of T. skrjabini was seen as a cessation of development; shrinking embryo plugs destruction, the release of underdeveloped larvae from eggs, and their death. During the use of this disinfectant, the changes in morphometric data of Trichuris eggs in test cultures were noticeable. At the most effective disinfectant concentrations and exposures, the dimensions of eggs were changed significantly: length smaller by 3.8–3.9 % (71.9–72.0 μm) and width more significant by 5.0–5.2 % (34.9–35.0 μm) as compared to those parameters in control (74.8 and 33.2 μm). This is evidence of the violations in nematodes' egg development. The data obtained allow us to recommend the disinfectant of domestic production, “Arquadez-plus”, for effectively controlling and preventing trichurosis in sheep on livestock farms.

This article aims to ground education as a competitive advantage of business based on content and bibliometric analysis. The paper examines the relationship between education level and business quality and leadership. It is highlighted that matching the level of education with business needs can ensure a higher level of labour productivity and better company results. The higher the level of education, the more an employee can benefit the company by working more efficiently and working with more ideas and innovations. The article also considers the importance of continuous learning and skill development for increasing business competitiveness and leadership in the modern world. For reaching the research goal, the methodology of data collection, content analysis, and synthesis from various sources, as well as bibliometric analysis of scientific publications indexed by the Scopus database using Bibliometrix and VosViewer software and R Studio programming language, was used. Over the past few years, the impact of education on business has received significant interest in the scientific community, as evidenced by the growing number of publishing articles indexed by the Scopus database. Four research clusters covered 10,914 keywords, and 95,636 connections in this context were formed. Multiple Correspondence Analysis allows the discovery of underlying structures in a set of categorical data (niche topics; developing topics; declining themes; most common topics and main topics). The research also covers case studies of companies that invest in training their employees to study the impact of such investments on business efficiency and competitiveness and analyses the opinions of business and education experts to assess the impact of education on business and the economy. The results of the conducted analysis confirm that investing in education is useful for business, contributes to the attraction of highly qualified employees, increases the level of productivity and competitiveness, and is also a guarantee of ensuring the successful functioning of the company in unpredictable conditions.

The purpose of this article is to characterise challenges and opportunities in the ‘business-education-science’ system in the context of innovation development based on cross-country cluster analysis. The article examines the relationship between science, education and business and their mutual influence on modern society. The main challenges facing science, education and business are considered, and opportunities for cooperation between these fields to overcome them are identified. Key factors that influence the effectiveness of scientific research, the quality of education, and the success of business are also determined, with an emphasis on the important role of cooperation in the ‘business-education-science’ system in ensuring their impact. To reach article’s purpose, a complex methodology was applied, which includes the following stages: collection of information about the current state of science, education, and business; a review of expert opinions and analytical reports on the problems of the interaction of science, education and business; methods of cross-country cluster analysis using STATISTICA 10 software (the k-Means method, the square of the Euclidean metric, etc. for a comparative analysis between 19 countries from a sample to find out which of them have better indicators in the respective fields). The statistical base is formed from the European Union and the WIPO data, which cover 10 key indicators in the context of the development of science, education and business and their affect the country's competitiveness in the global world. As a result, there are two formed clusters: the first includes the USA and China that have the highest level of education-science-business development and the second cluster includes other countries from the sample with a less developed education-science-business sector. For these countries the recommendations have been developed to strengthen their education-science-business sector, in particular: creating favourable conditions for investing in science and business, attracting talented scientists, and supporting their activities, increasing allocations for education, and improving the quality of education, strengthening partnerships between universities and enterprises to create innovative projects and other activities. The obtained results can be useful for further research and for making managerial decisions at different levels of government in the context of innovation development, including through the strengthening of coopetition between business, education, and science.

The purpose of this article is to present psychological study of the functional state of the patient. Methods of the research. The following theoretical methods of the research were used to solve the tasks formulated in the article: a categorical method, structural and functional methods, the methods of the analysis, systematization, modeling, generalization. The method of organizing an empirical research was used as an experimental method. The results of the research. The results show, that there are four primary clusters. They consist of one basic variable, with the help of which we identify them. These clusters characterize the current state of patients with ischemic stroke at the time of the start of rehabilitation measures. The interaction of “Factor of deviation from the autogenous norm, pathology of the somatic state” and “Factor of instability of health and well-being” make up the first and second primary clusters, which are dominant. “Anxiety Factor” and “The Factor of passivity, physical limitation of activity” form the third and the fourth primary clusters. Conclusions. Such interaction of the studied variables indicates the presence of psychological discomfort or a state of a physiological discomfort. It is a source of anxiety. In the first place, in order of significance, the restoration of lost motor functions appears in a case of such patients, when the patient feels only a certain anxiety from the view of his/her psycho-physiological state, without giving himself/herself an account of the reason for the presence of anxiety. The limits of psychological capabilities of patients are significantly narrowed – this is evidenced by the value of the interaction of the indicator “Factor of deviation from the autogenous norm, pathology of the somatic state” and “Anxiety Factor”. These indicators are quite low, although their rehabilitation potential is often high (forecast by a specialist neurologist). Such patients are not fully oriented to the process of physical rehabilitation, they have no or rather low motivation to engage in physical exercises. This should also be taken into account when planning and implementing rehabilitation measures, which we have done in the formative experiment.

The subject of this study is systems for detection and identification (D&I) of explosive ordnance (EO). The aim of this study is to develop a concept, general structure, and models of a robotic-biological system for D&I of EO (RBS-D&I). The objectives are as follows: 1) to classify mobile systems for D&I of EO and suggest a concept of RBS-D&I; 2) to develop the general structure of RBS-D&I consisting of robotic (flying and ground) and biological subsystems; 3) to develop models of RBS-D&I including automaton, hierarchical, and operational ones; 4) to describe tasks and planned results of the article-related scientific project; and 5) to discuss research results. The following results were obtained. 1) The general structure of the RBS-D&I. The structure comprises the following levels: control and processing centres (mobile ground control and processing centre (MGCPC) and virtual control and processing centre); forces for detection and identification (fleet of unmanned aerial vehicles (FoU), biological detection information subsystem (BDIS), and robotic detection information subsystem (RDIS)); interference; natural covers and a bedding surface; and target objects (all munitions containing explosives, nuclear fission or fusion materials and biological and chemical agents). 2) A concept of RBS-D&I. The concept is based on RBS-D&I description, analysis, development, and operation as an integrated complex cyber-physical and cyber-biological system running in changing physical and information environments. 3) The RBS-D&I automata model. The model describes RBS-D&I operating in two modes. In mode 1, FoU and BDIS operate separately and interact through the MGCPC only. In mode 2, depending on the specifics of the tasks performed, FoU and RDIS can directly interact among themselves or through the MGCPC. 4) hierarchical model. The model has two sets of vertices: EO detection and platforms equipped with the necessary sensors. 5) An operational cycle model. The model describes land release operations via a methodology of functional modeling and graphic description of IDEF0 processes. Conclusions. The proposed concept and RBS-D&I solutions can provide high-performance and guaranteed EO detection in designated areas by the implementation of an intelligent platform and tools for planning the use of multifunctional fleets of UAVs and other RBS-D&I subsystems.

Introduction. The antigen complex of opportunistic pathogenic bacteria (ACOPB) has a protective effect against avian influenza viruses, herpes virus type 2, and other viruses that cause acute respiratory viral infections. In the context of the COVID-19 pandemic, an important task is to find out whether ACOPB has a protective effect against SARS-CoV-2. The purpose of the study was to evaluate in vitro the ACOPB virus-inhibitory activity against the Dubrovka laboratory strain of SARS-CoV-2. Materials and methods. The study was performed using Vero cell line CCL-81, human peripheral blood mononuclear cells (PBMCs), mouse monoclonal anti-idiotypic antibodies structurally mimicking biological effects of human interferons (IFNs), the Dubrovka laboratory strain of SARS-CoV-2. The infectivity of the virus was assessed by two methods: by virus titration using cell cultures and the limiting dilution method when the results are assessed by a cytopathic effect; the second method was a plaque assay. The in vitro virus inhibition test was performed using the cell culture susceptible to SARS-CoV-2; the mixture containing a specific dose of the virus and a two-fold dilution of ACOPB was transferred to the cell culture after the ACOPB medication had interacted with the virus at 4C for 2 hours. The ACOPB virus-inhibitory activity against SARS-CoV-2 was assessed by the functional activity of / and IFN receptors (RIFN) in human PBMCs induced in vitro by ACOPB and the ACOPB mixture with the specific dose of SARS-CoV-2. The RIFN expression level was measured by the indirect membrane immunofluorescence test. Results. Hemagglutination assay using chicken, mouse, guinea pig, and human red blood cells was performed for detection of the SARS-CoV-2 inhibitory protein. The lysate of Vero CCL-81 cells infected with SARS-CoV-2 Dubrovka demonstrated the highest hemagglutination activity with guinea pig red blood cells and low titers of hemagglutination in the virus-containing fluid. The virus inhibition test in the Vero CCL-81 cell culture demonstrated that ACOPB inhibited 10 doses of SARS-CoV-2 Dubrovka with the titer 1 : 32, providing 100% protection of the cell culture for 8 days (the monitoring period). ACOPB induced / and RIFN expression on membranes of human PBMCs in in vitro cultures and decreased RIFN / and expression after its interaction with SARS-CoV-2 Dubrovka. Conclusion. The experimental studies including the virus inhibition test in the cell culture susceptible to SARS-CoV-2 Dubrovka and the indirect membrane immunofluorescence assay using monoclonal anti-idiotypic antibodies mimicking IFN-like properties demonstrated that ACOPB had both an immunomodulatory and a virus-inhibitory effect.

With the continuous development of science and technology, information technology has promoted the development of knowledge economy, advanced science and technology has become an important development in the era of knowledge economy. In this era, knowledge workers are at the core competitiveness, and knowledge compound talents have become the pivotal resources. In order to enhance the enterprise market competitiveness, daily work efficiency and technological innovation and development, one is bound to try to improve and innovate in the enterprise human resource management. The main aim of the article was to substantiate and prove the importance of personnel development management for the competitiveness of enterprises using the example of human resources in China. To achieve the goal, the following main tasks were formulated: in the personnel management system, the place of the personnel development management system is determined and its structure is formed; in accordance with the obtained structure, a conceptual model for managing the development of personnel of enterprises is elaborated, adapting the classification of types of training of personnel in working conditions, forming a system of professional development of personnel at the enterprise, clarifying the meaning of the concept of «personnel development management». The methodological basis of the study was the basis of dialectical logic, attributive and system approaches to the study of the processes of managing the development of personnel of enterprises.

Introduction. The application of non-price criteria in road sector public procurement procedure is an important step towards harmonizing European approaches to tendering. Although Ukrainian legislation allows the use of non-price criteria during the procurement process, it should be noted that the methodology for applying non-price criteria for the implementation of environmental protection measures is not yet sufficiently developed. Problem statement. One of the prerequisites for such criteria effective application in road sector public procurement procedure is methodology updating for evaluating tenders, taking into account European approaches to their evaluation. Purpose. Thus, the aim of this study is to develop non-price criteria for environmental measures implementation (or environmental friendliness of resources used) for public procurement in the field of road management.

The use of modern breeding methods, biotechnology, and molecular genetics makes it possible to identify promising accessions with specified economically important traits at early pre-breeding stages. The success of creating new varieties depends on the availability of unique collections of plant genetic resources, information about genomes, possibility of in vitro cultivation with high regenerative capacity, and practical skills and competencies in this area. One of the advanced methods for accelerating the breeding process is genome editing using the CRISPR/Cas system. This method allows the effective modification of genes in order to obtain varieties with desired traits. In 2022, a new youth laboratory of genetics, breeding, biotechnology of ornamental and berry crops was set up at VIR as part of the National Project "Science and Universities". It is noteworthy that this event coincided with the 135th anniversary of the birth of N.I. Vavilov. The work of the laboratory is aimed at obtaining lines with desired properties for the further breeding process; identifying target genes of economically important traits for obtaining new varieties, lines, and hybrids; as well as creating protocols for the accelerated reproduction of virus-free material of commercially demanded varieties oriented towards import substitution. This review discusses current trends in breeding of ornamental and berry crops: e.g., flower color change in snapdragon and peony; flower aroma improvement in rose; architectonics change in actinidia; and increase of resistance to stress factors in blackberries, strawberries, and grapes.

This paper presents the results of an evaluation of corrosion properties of PEO pretreated AlMg3 aluminum alloy samples with polymer coatings obtained by dip-coating in a suspension of superdispersed polytetrafluoroethylene (SPTFE) in a solution of polyvinylidene fluoride (PVDF) in N-methyl-2-pyrrolidone at different PVDF:SPTFE ratios (1:1, 1:3, 1:5, and 1:10). The electrochemical tests showed that samples with a coating formed at a ratio of PVDF to SPTFE of 1:5 possessed the best corrosion properties. The corrosion current density of these samples was more than five orders of magnitude lower than this parameter for bare aluminum alloy. During the 40-day salt spray test (SST) for samples prepared in a suspension at a PVDF:SPTFE ratio of 1:1–1:5, the formation of any pittings or defects was not detected. The PVDF:SPTFE 1:5 sample demonstrated, as a result of the 40-day SST, an increase in corrosion current density of less than an order of magnitude. The evolution of the protective properties of the studied samples was assessed by a two-year field atmospheric corrosion test on the coast of the Sea of Japan. It was revealed that the samples with the PVDF:SPTFE 1:5 coating had electrochemical parameters that remained consistently high throughout the one year of exposure. After this period, the polymer layer was destroyed, which led to a deterioration in the protective characteristics of the coatings. [ABSTRACT FROM AUTHOR]

In the rapidly evolving domain of cryptocurrency trading, accurate market data analysis is crucial for informed decision making. Candlestick patterns, a cornerstone of technical analysis, serve as visual representations of market sentiment and potential price movements. However, the sheer volume and complexity of cryptocurrency price time-series data presents a significant challenge to traders and analysts alike. This paper introduces an innovative rule-based methodology for recognizing candlestick patterns in cryptocurrency markets using Python. By focusing on Ethereum, Bitcoin, and Litecoin, this study demonstrates the effectiveness of the proposed methodology in identifying key candlestick patterns associated with significant market movements. The structured approach simplifies the recognition process while enhancing the precision and reliability of market analysis. Through rigorous testing, this study shows that the automated recognition of these patterns provides actionable insights for traders. This paper concludes with a discussion on the implications, limitations, and potential future research directions that contribute to the field of computational finance by offering a novel tool for automated analysis in the highly volatile cryptocurrency market.

We present a union of three measurement systems on the basis of the Siberian lidar station and mobile ozone lidar. The lidars are designed for studying the ozonosphere using the method of differential absorption and scattering, as well as for studying aerosol fields using elastic single scattering. The systems are constructed on the basis of Nd:YAG lasers (SOLAR) and an Nd:YAG laser (LOTIS TII), a XeCl laser (Lambda Physik) and receiving telescopes assembled using the Kassegrain system with a diameter 0.35 m and the Newtonian 0.5 m system. Lidars operate in photon-counting mode and record lidar signals with a spatial resolution from 1.5 m to 160 m at sensing wavelengths of 299/341 nm in the altitude range of ~0.1–12 km and ~5–20, and at 308/353 nm in the altitude range of ~15–45 km. The union of these three measurement systems was used to carry out field experiments of atmospheric lidar sensing in Tomsk and to present the results of retrieving the vertical profile of the ozone concentration. In this study, coverage of the entire ozonosphere by the lidars was carried out for the first time in Russia.

The alloy element Nb plays an important role in improving the performance of zirconium alloys in nuclear reactors. The effect mechanism of Nb doping on mechanical and thermodynamic properties was investigated using experimental and theoretical methods. The results of this study showed us that Nb doping refines grains and enhances hardness. The hardness increases from 2.67 GPa of pure Zr to 2.99 GPa of Zr1.5Nb. Depending on the first-principles calculations, the hardness decreases with the increase in the Nb concentration in the Zr matrix, namely from 2.45 Gpa of pure Zr to 1.78 GPa of Zr1.5Nb. If the first-principles calculations indicate that the hardness decreases with the increase in the Nb concentration in the Zr matrix, grain refinement or defects could play a major role in the increase in hardness. Furthermore, regarding the effect of Nb doping on thermal expansion coefficients, the increase in Nb content causes the thermal expansion coefficients to decrease, which might stem from the strong binding energy between Nb and Zr atoms. The thermal conductivities of three samples show similar changing trends, indicating that thermal conductivity begins to decrease at room temperature and reaches a minimum value of around 400 °C. The thermal conductivity of pure zirconium samples is consistently higher, is more obvious than that of Nb-doped samples in the test range, and decreases with an increase in the doping concentration. The possible reasons for this might stem from the distortion of the Zr matrix due to Nb substitution doping and grain refinement, both of which cause phonon propagation scattering and thus hinder the propagation of phonons. The results obtained herein may be useful for the development of advanced nuclear fuels and waste forms that utilize zirconium in applications beyond their current usage.

Perylenediimides (PDIs) are composed of a central perylene ring, on which are grafted two imide groups at the peri positions. Thionated PDIs are characterized by the substitution of one or more oxygen atoms of these imide functions with sulfur atoms. This structural modification alters the electronic properties with a redshift of the optical absorption accompanied by modification of the charge transport characteristics compared to their non-thionated counterparts. These properties make them suitable candidates for applications in optoelectronic devices, such as organic light-emitting diodes and organic photovoltaics. Moreover, the presence of sulfur atom(s) can favor the promotion of reactive oxygen species production for photodynamic and photothermal therapies. These thionated PDIs can be synthesized through the post-functionalization of PDIs by using a sulfurizing reagent. Nevertheless, the main drawbacks remain the difficulties in adjusting the degree of thionation and obtaining tri- and tetrathionated PDIs. Up to now, this thionation reaction has been described almost exclusively using Lawesson’s reagent. In the current study, we present our first investigations into an alternative reagent to enhance selectivity and achieve a greater degree of thionation. The association of phosphorus pentasulfide with hexamethyldisiloxane (Curphey’s reagent) clearly demonstrated higher reactivity compared with Lawesson’s reagent to attain multi-thionated PDIs.

The enhancement of the plant seed yield and quality represents the basis of the successful productivity of the deriving crop. The effect of single and combined foliar treatments of lettuce plants with sodium selenate and garlic bulb extract on seed yield and quality and on mature plant biochemical characteristics was investigated using four lettuce cultivars (Bouquet, Picnic, Moskovsky parnikovy and Cavalier). The seed production of plants treated with Se increased by 20–41%, compared to the untreated control plants, while the augmentation was as much as 10–23% and 17–27% under garlic extract and the joint application of Se and garlic, respectively. Garlic extract stimulated the accumulation of Se in lettuce seeds, which rose by 1.21–1.29 times compared to the Se-treated plants. The proline levels in lettuce seeds exceeded the corresponding values recorded in the control ones by 1.32–1.64 times in the case of the Se supply, 1.10–1.47 times upon garlic extract application and 1.09–1.31 times under the combined Se/garlic treatment. All the treatments given to lettuce plants increased the leaf weight by 1.10–1.30 times, compared to the untreated control. The seed Se levels positively correlated with the leaf weight (r = 0.621; p < 0.005), chlorophyll (r = 0.672, p < 0.002) and total antioxidant activity (AOA; r = 0.730, p < 0.001) of plants grown from these seeds. Positive correlations were also recorded between the seed proline content and lettuce plant leaf weight, chlorophyll and AOA (r = 0.868, 0.811 and 0.815, respectively, at p < 0.001). Lettuce yield was positively correlated with the leaf AOA, chlorophyll and ascorbic acid content (r = 0.942, 0.921 and 0.665, respectively, at p < 0.001). The results indicate high prospects of Na2SeO4 and garlic extract application to seed-addressed lettuce plants, to improve seed productivity and quality, as well as lettuce yield and quality.

The article analyses the functioning of the war-time Ukrainian humorous discourse in general and the cognitive mechanisms of humor, including the “Availability Heuristic” cognitive pattern in particular. The study aims to examine 12 Ukrainian war-time jokes and to reveal main cognitive patterns and accompanying stylistic figures producing the comic effect. All jokes manifest the application of the “Availability heuristic” cognitive pattern inherent to the war period when old pre-war realities are changed with new war-time realities and explained in a funny way. The study addresses some cognitive and pragmatic aspects of the war-time Ukrainian humor, focusing on the role of cognitive patterns in selecting stylistic humor devices, while processing the incoming information and shaping the cognitive frameworks of humor perception and creation. The paper reveals the main cognitive patterns, including the “Availability Heuristic,” the “Distinct contrast,” the “Negativity Thinking,” the “Superiority or Illusionary Superiority,” the “Easel,” and their humorous actualization through such stylistic figures as paraprosdokian, irony, bathos, double entendre, pun, metaphor, and pastiche in its narrow meaning. The researched Ukrainian jokes are interwoven with the situational context of the dramatic events within the temporality of the speedy streaming news of the Russian-Ukrainian war. The paper explores the main pragmatic functions of Ukrainian war-time humorous discourse and makes additional remarks about a number of affirmations from some humor theories.

Дана стаття присвячена визначенню та ана­лізу основних методів російської інформаційної пропаганди і дослідженню їх реального впливу на створення негативного іміджу України у між­народному співтоваристві. Аналіз зарубіжної преси показав, що західний інформаційний простір представляє собою суміш професійних досліджень, фальсифікацій, пропаганди, відкритого маніпулювання та примітивних тверджень. Важливо відзначити, що сьогодні іс­нує достатньо велика кількість закордонних ви­дань, які, підтримуючи путінський режим, все ще розглядають Україну і росію як нероздільний об'єкт і які практично завжди публікують нега­тивні матеріали про Україну та її народ. До та­ких джерел належать деякі інформаційні ресурси Сербії, Франції, Норвегії, Туреччини тощо. Більш об'єктивну та правдиву інформацію за­хідні оглядачі мають змогу отримувати від офі­ційних представників держави, дипломатів, від впливових світових видань, які надають якісну аналітику та експертні висновки. Через сайти ор­ганізацій, які надають аналітичні та статистичні матеріали. Також відомі блогери, відверто заяв­ляючи про свої політичні вподобання та підтрим­ку, можуть формувати думку частини людей. Серед основних інформаційних методів, що застосовуються росією в боротьбі проти Украї­ни, є маніпуляція історією та подіями сьогоден­ня, перекручування історичних фактів та подій сучасності, створення негативної ідентичності України в очах міжнародної громадськості, спе­куляція фактами, видуванням рейкових новин тощо. Загалом, поширення російської пропаганди щодо України має негативний вплив на сприй­няття її в світі. А це, в свою чергу, може ство­рювати суттєві перешкоди для збереження та підтримки суверенітету України, а також її між­народної інтеграції. Для боротьби з цим явищем важливо продовжувати зміцнювати міжнародну співпрацю у сфері інформаційної безпеки та від­крито висвітлювати факти та правдиву інформа­цію про Україну.

The purpose of the article is to study the peculiarities of the implementation of innovative strategies by Ukrainian farmers, to identify influencing factors, including the influence of global market factors on the effectiveness of the implementation of strategies, and to develop a mathematical approach to assessing the influence of uncertain factors. The methodological basis of the article is the methods and forms of scientific knowledge accepted in science, such as methods: of comparative and abstract-logical analysis, induction and deduction, abstraction, and mathematical formalization. A stratification of the factors of the negative impact of globalization, which slow down the implementation of the innovative strategy and create threats to the activity of agricultural enterprises, is carried out. It is indicated that the main directions of improvement of the innovation strategy should be assessment, consideration, and neutralization of the influence of globalization factors. It is also indicated that this leads to the heterogeneity of the implementation of the innovative management strategy of agricultural enterprises. Prospective directions for the implementation of innovative strategies in agricultural production are stratified. The stages of the implementation of the innovation strategy in the conditions of globalization and the tasks of management for the implementation of the innovation strategy in the global conditions are determined. Peculiarities of the implementation of innovative strategies in Ukraine are revealed. A mathematical model was developed to assess the influence of uncertain global factors, which will allow for reducing risks for the implementation of significant innovative strategies. It is indicated that significant innovative projects could lead to the transformation of agribusiness activities and the need for permanent implementation of innovative processes. It is indicated that thanks to the systemic innovation process, a synthesis of the resource and innovation model of enterprise development could be formed. Taking into account the specifics of innovative strategies and using the developed mathematical approach to assess the influence of uncertain global factors will allow reducing risks in the implementation of innovative strategies and improving their management.

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.

Leukemic relapse remains a major barrier to successful allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aggressive hematologic malignancies. The basis for relapse of advanced lymphoid malignancies remains incompletely understood and may involve escape from the graft-versus-leukemia (GvL) effect. We hypothesized that for patients with chronic lymphocytic leukemia (CLL) treated with allo-HSCT, leukemic cell-intrinsic features influence transplant outcomes by directing the evolutionary trajectories of CLL cells. Integrated genetic, transcriptomic, and epigenetic analyses of CLL cells from 10 patients revealed that the clinical kinetics of post-HSCT relapse are shaped by distinct molecular dynamics. Early relapses after allo-HSCT exhibited notable genetic stability; single CLL cell transcriptional analysis demonstrated a cellular heterogeneity that was static over time. In contrast, CLL cells relapsing late after allo-HSCT displayed notable genetic evolution and evidence of neoantigen depletion, consistent with marked single-cell transcriptional shifts that were unique to each patient. We observed a greater rate of epigenetic change for late relapses not seen in early relapses or relapses after chemotherapy alone, suggesting that the selection pressures of the GvL bottleneck are unlike those imposed by chemotherapy. No selective advantage for human leukocyte antigen (HLA) loss was observed, even when present in pretransplant subpopulations. Gain of stem cell modules was a common signature associated with leukemia relapse regardless of posttransplant relapse kinetics. These data elucidate the biological pathways that underlie GvL resistance and posttransplant relapse.

Study of stress-corrosion cracking of welded joints made of X70 steel at cathodic polarization in near neutral solution NS4 was carried out. It was established that the tendency of base metal of X70 steel to stress-corrosion cracking, estimated by KS coefficient, increases from 1.07 to 1.13 whereas polarization potential changing from the corrosion potential to maximum protective potential -1.05 V. Such regularity correlates with increasing of hydrogen penetration through X70 steel, which at maximum protective potential -1.05 V is equal to 0.000518 mol/m3 . Susceptibility of welded joint is lower than the base metal, KS coefficient change not much near the value 1.0. With increasing of polarization potential from -0,75V to -1.05V fracture surface of X70 steel characterized by decreasing in the size of holes and the appearance of flat areas, through that the rupture occurred. A similar nature of the rupture was observed for the welded joint, but visually larger proportion of flat areas can be noted. It was established that the rupture of the welded joint occurs on the base metal, which allows to propose stress-corrosion cracking susceptibility factor KS to be legitimately used for estimation to stress-corrosion cracking of welded joint, provided the weld is performed in a high-quality manner. Stress-corrosion cracking results of welded joint of X70 steel correlate satisfactorily with the experience of stress-corrosion cracking on main gas pipelines, where stress-corrosion cracks form and develop along the base metal of gas pipelines.