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201. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiovasculaire Immunologie, Centraal Diagnostisch Laboratorium, Infection & Immunity, Aios en Stafsecr. Cardiologie, Arts Assistenten Cardiologie, Experimentele Afd. Cardiologie 2, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, Hoefer, Imo E., Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiovasculaire Immunologie, Centraal Diagnostisch Laboratorium, Infection & Immunity, Aios en Stafsecr. Cardiologie, Arts Assistenten Cardiologie, Experimentele Afd. Cardiologie 2, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, and Hoefer, Imo E.

Published
2017

202. Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients

Author

Barasa, Benjamin A, van Oirschot, Brigitte A, Bianchi, Paola, van Solinge, Wouter W, Heck, Albert J R, van Wijk, Richard, Slijper, Monique, Barasa, Benjamin A, van Oirschot, Brigitte A, Bianchi, Paola, van Solinge, Wouter W, Heck, Albert J R, van Wijk, Richard, and Slijper, Monique

Abstract

PURPOSE: To date it still remains a challenge to correctly and timely diagnose red blood cell (RBC) enzymopathies that result in hereditary non-spherocytic hemolytic anemia, the third most common of which is pyrimidine 5'-nucleotidase (P5N) deficiency with just over 100 cases recognized and confirmed worldwide.EXPERIMENTAL DESIGN: We have investigated the RBC proteome of a patient with P5N deficiency due to a homozygous frameshift mutation in the NT5C3A gene. Protein expression levels were analyzed against healthy controls and against patients with hemolytic anemia of different origin, to account for the patient's elevated reticulocyte versus RBC ratio.RESULTS: Stringent relative quantification of the patient's protein levels revealed reduced levels of P5N, and unexpectedly, also decreased levels of transketolase, an enzyme involved in the non-oxidative phase of the pentose phosphate pathway, one of the few key pathways active in RBCs. Immunoblotting of whole blood samples from this and other P5N deficient patients with dissimilar mutations indicated that P5N deficiency was correlated with reduced transketolase levels.CONCLUSIONS AND CLINICAL RELEVANCE: Consequently, insight into patient RBC proteomes illustrates potential benefit of coupling quantitative proteomics strategies with routine HNSHA diagnostic procedures. Proteomics facilitates finding novel biomarkers for HNSHA patients, e.g. suffering from P5N deficiency, providing new prospects for future diagnosis and therapy. This article is protected by copyright. All rights reserved.

Published
2016

205. Translational failure of anti-inflammatory compounds for myocardial infarction : a meta-analysis of large animal models

Author

van Hout, GPJ, Jansen of Lorkeers, SJ, Wever, Kimberly E, Sena, Emily S, Kouwenberg, Lisanne H J A, van Solinge, Wouter W, Macleod, Malcolm R, Doevendans, Pieter A, Pasterkamp, Gerard, Chamuleau, Steven A J, Höfer, IE, van Hout, GPJ, Jansen of Lorkeers, SJ, Wever, Kimberly E, Sena, Emily S, Kouwenberg, Lisanne H J A, van Solinge, Wouter W, Macleod, Malcolm R, Doevendans, Pieter A, Pasterkamp, Gerard, Chamuleau, Steven A J, and Höfer, IE

Published
2016

206. Validity of diagnostic codes and laboratory measurements to identify patients with idiopathic acute liver injury in a hospital database

Author

Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Udo, Renate, Maitland-van der Zee, Anke H., Egberts, Toine C. G., den Breeijen, Johanna H., Leufkens, Hubert G. M., van Solinge, Wouter W., De Bruin, Marie L., Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Udo, Renate, Maitland-van der Zee, Anke H., Egberts, Toine C. G., den Breeijen, Johanna H., Leufkens, Hubert G. M., van Solinge, Wouter W., and De Bruin, Marie L.

Published
2016

207. Patient monitoring: the hidden costs of antipsychotic treatment

Author

Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Nederlof, Mariëtte, Frederix, Geert W J, Stoker, Lennart J, van Solinge, Wouter W, Egberts, Toine C G, Heerdink, Eibert R, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Nederlof, Mariëtte, Frederix, Geert W J, Stoker, Lennart J, van Solinge, Wouter W, Egberts, Toine C G, and Heerdink, Eibert R

Published
2016

209. Routinely analyzed leukocyte characteristics improve prediction of mortality after coronary angiography

Author

Gijsberts, Crystel M, Ellenbroek, Guilielmus HJM, ten Berg, Maarten J, Huisman, Albert, van Solinge, Wouter W, Asselbergs, Folkert W, den Ruijter, Hester M, Pasterkamp, Gerard, de Kleijn, Dominique PV, Höfer, Imo E., Gijsberts, Crystel M, Ellenbroek, Guilielmus HJM, ten Berg, Maarten J, Huisman, Albert, van Solinge, Wouter W, Asselbergs, Folkert W, den Ruijter, Hester M, Pasterkamp, Gerard, de Kleijn, Dominique PV, and Höfer, Imo E.

Published
2016

210. Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma

Author

Bastian,Okan, Kuijer,Anne, Koenderman,Leo, Stellato,Rebecca K., van Solinge,Wouter W., Leenen,Luke P.H., Blokhuis,Taco J., Bastian,Okan, Kuijer,Anne, Koenderman,Leo, Stellato,Rebecca K., van Solinge,Wouter W., Leenen,Luke P.H., and Blokhuis,Taco J.

Abstract

Okan W Bastian,1 Anne Kuijer,1 Leo Koenderman,2 Rebecca K Stellato,3 Wouter W van Solinge,4 Luke PH Leenen,1 Taco J Blokhuis1 1Department of Traumatology, 2Department of Respiratory Medicine, 3Department of Biostatistics and Research Support, Julius Center, 4Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands Abstract: Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia. The peripheral blood-count curves of leukocytes, neutrophils, monocytes, and thrombocytes differed significantly between patients with normal and impaired fracture healing during the first 2 weeks after trauma (P-values were 0.0122, 0.0083, 0.0204, and <0.0001, respectively). Mean myeloid cell counts were above reference values during the second week after injury. Our data indicate that leukocyte kinetics differ significantly between patients with normal and impaired fracture healing during the first 2 weeks after major injury. This finding suggests that the systemic immune response to major trauma can disturb tissue regeneration. Keywords: SIRS, inflammation, neutrophils, myelopoiesis, regeneration

Published
2016

211. Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients

Author

Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Biomol.Mass Spectrometry & Proteom., Barasa, Benjamin A, van Oirschot, Brigitte A, Bianchi, Paola, van Solinge, Wouter W, Heck, Albert J R, van Wijk, Richard, Slijper, Monique, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Biomol.Mass Spectrometry & Proteom., Barasa, Benjamin A, van Oirschot, Brigitte A, Bianchi, Paola, van Solinge, Wouter W, Heck, Albert J R, van Wijk, Richard, and Slijper, Monique

Published
2016

212. New mAb therapies in multiple myeloma: interference with blood transfusion compatibility testing

Author

Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, de Vooght, Karen M K, Oostendorp, Marlies, van Solinge, Wouter W., Other research (not in main researchprogram), CDL Staf Patiëntenzorg KC, LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, de Vooght, Karen M K, Oostendorp, Marlies, and van Solinge, Wouter W.

Published
2016

213. Patient monitoring: the hidden costs of treatment with antipsychotics

Author

HTA Onderzoek Team 1, HEE, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Apotheek, Nederlof, Mariëtte, Frederix, Geert W J, Stoker, Lennart J., van Solinge, Wouter W., Egberts, Toine C G, Heerdink, Eibert R., HTA Onderzoek Team 1, HEE, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Apotheek, Nederlof, Mariëtte, Frederix, Geert W J, Stoker, Lennart J., van Solinge, Wouter W., Egberts, Toine C G, and Heerdink, Eibert R.

Published
2016

214. Overestimation of hypoglycemia in infants with a high hematocrit

Author

LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, CDL Staf Patiëntenzorg KC, Kemperman, Hans, van Solinge, Wouter W, de Vooght, Karen MK, LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, CDL Staf Patiëntenzorg KC, Kemperman, Hans, van Solinge, Wouter W, and de Vooght, Karen MK

Published
2016

215. Routinely analyzed leukocyte characteristics improve prediction of mortality after coronary angiography

Author

Experimentele Afd. Cardiologie 1, Cardiovasculaire Immunologie, LKCH Staf Patiëntenzorg, Infection & Immunity, Circulatory Health, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Gijsberts, Crystel M, Ellenbroek, Guilielmus HJM, ten Berg, Maarten J, Huisman, Albert, van Solinge, Wouter W, Asselbergs, Folkert W, den Ruijter, Hester M, Pasterkamp, Gerard, de Kleijn, Dominique PV, Höfer, Imo E., Experimentele Afd. Cardiologie 1, Cardiovasculaire Immunologie, LKCH Staf Patiëntenzorg, Infection & Immunity, Circulatory Health, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Gijsberts, Crystel M, Ellenbroek, Guilielmus HJM, ten Berg, Maarten J, Huisman, Albert, van Solinge, Wouter W, Asselbergs, Folkert W, den Ruijter, Hester M, Pasterkamp, Gerard, de Kleijn, Dominique PV, and Höfer, Imo E.

Published
2016

216. Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Author

CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, CDL Staf Research, Kooijmans, Sander A A, Aleza, Clara Gómez, Roffler, Steve R, van Solinge, Wouter W, Vader, Pieter, Schiffelers, Raymond M, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, CDL Staf Research, Kooijmans, Sander A A, Aleza, Clara Gómez, Roffler, Steve R, van Solinge, Wouter W, Vader, Pieter, and Schiffelers, Raymond M

Published
2016

217. Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

Author

Cardiologie Arts-onderzoekers, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Cardiologie, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, van Hout, GPJ, Jansen of Lorkeers, SJ, Wever, Kimberly E, Sena, Emily S, Kouwenberg, Lisanne H J A, van Solinge, Wouter W, Macleod, Malcolm R, Doevendans, Pieter A, Pasterkamp, Gerard, Chamuleau, Steven A J, Höfer, IE, Cardiologie Arts-onderzoekers, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Cardiologie, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, van Hout, GPJ, Jansen of Lorkeers, SJ, Wever, Kimberly E, Sena, Emily S, Kouwenberg, Lisanne H J A, van Solinge, Wouter W, Macleod, Malcolm R, Doevendans, Pieter A, Pasterkamp, Gerard, Chamuleau, Steven A J, and Höfer, IE

Published
2016

218. Validity of diagnostic codes and laboratory measurements to identify patients with idiopathic acute liver injury in a hospital database

Author

Apotheek, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Udo, Renate, Maitland-van der Zee, Anke H., Egberts, Toine C G, den Breeijen, Johanna H., Leufkens, Hubert G M, van Solinge, Wouter W., De Bruin, Marie L., Apotheek, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Udo, Renate, Maitland-van der Zee, Anke H., Egberts, Toine C G, den Breeijen, Johanna H., Leufkens, Hubert G M, van Solinge, Wouter W., and De Bruin, Marie L.

Published
2016

221. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Author

van Hout, Gerardus P.J., primary, Bosch, Lena, additional, Ellenbroek, Guilielmus H.J.M., additional, de Haan, Judith J., additional, van Solinge, Wouter W., additional, Cooper, Matthew A., additional, Arslan, Fatih, additional, de Jager, Saskia C.A., additional, Robertson, Avril A.B., additional, Pasterkamp, Gerard, additional, and Hoefer, Imo E., additional

Published
2016
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222. One-Year Mortality, Causes of Death, and Cardiac Interventions in Patients with Postoperative Myocardial Injury

Author

van Waes, Judith A. R., primary, Grobben, Remco B., additional, Nathoe, Hendrik M., additional, Kemperman, Hans, additional, de Borst, Gert Jan, additional, Peelen, Linda M., additional, van Klei, Wilton A., additional, Buhre, Wolfgang F., additional, de Graaff, Jurgen C., additional, Kalkman, Cor J., additional, van Wolfswinkel, Leo, additional, Doevendans, Pieter A., additional, Grobbee, Diederik E., additional, van Solinge, Wouter W., additional, Leiner, Tim, additional, Leenen, Loek P. H., additional, and Moll, Frans L., additional

Published
2016
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227. Reducing Test Utilization in Hospital Settings: A Narrative Review.

Author

Bindraban, Renuka S., ten Berg, Maarten J., Naaktgeboren, Christiana A., Kramer, Mark H. H., van Solinge, Wouter W., and Nanayakkara, Prabath W. B.

Subjects
HOSPITAL laboratories, LABORATORY test panels, CLINICAL trials, META-analysis
Abstract

Background: Studies addressing the appropriateness of laboratory testing have revealed approximately 20% overutilization. We conducted a narrative review to (1) describe current interventions aimed at reducing unnecessary laboratory testing, specifically in hospital settings, and (2) provide estimates of their efficacy in reducing test order volume and improving patient-related clinical outcomes. Methods: The PubMed, Embase, Scopus, Web of Science, and Canadian Agency for Drugs and Technologies in Health-Health Technology Assessment databases were searched for studies describing the effects of interventions aimed at reducing unnecessary laboratory tests. Data on test order volume and clinical outcomes were extracted by one reviewer, while uncertainties were discussed with two other reviewers. Because of the heterogeneity of interventions and outcomes, no meta-analysis was performed. Results: Eighty-four studies were included. Interventions were categorized into educational, (computerized) provider order entry [(C)POE], audit and feedback, or other interventions. Nearly all studies reported a reduction in test order volume. Only 15 assessed sustainability up to two years. Patient-related clinical outcomes were reported in 45 studies, two of which found negative effects. Conclusions: Interventions from all categories have the potential to reduce unnecessary laboratory testing, although long-term sustainability is questionable. Owing to the heterogeneity of the interventions studied, it is difficult to conclude which approach was most successful, and for which tests. Most studies had methodological limitations, such as the absence of a control arm. Therefore, well-designed, controlled trials using clearly described interventions and relevant clinical outcomes are needed. [ABSTRACT FROM AUTHOR]

Published
2018
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229. Contributors

Author

Aarsand, Aasne K., Abbott, April N., Adeli, Khosrow, Anderson, Neil W., Apple, Fred S., Ayling, Ruth M., Babady, Esther, Badminton, Michael N., Badrick, Tony, Bais, Renze, Bazydlo, Lindsay A.L., Bechtel, Laura K., Bertholf, Roger L., Best, D. Hunter, Bjarnason, Ingvar, Block, Darci R., Blum, Lee M., Bossuyt, Patrick M.M., Boyd, James C., Brown, Sarah M., Buchan, Blake W., Burnett, David, Burnett, Leslie, Bystrom, Cory, Cappellini, Maria Domenica, Caulfield, Adam J., Ceriotti, Ferruccio, Chabot-Richards, Devon, Chen, Derrick J., Chen, Dong, Cheng, Steven, Cheung, Nai-Kong V., Chiu, Rossa W.K., Clarke, Nigel J., Cole, Timothy J., Cooper, Mark, Dayspring, Thomas D., Delaney, Michael P., Dietzen, Dennis J., Doern, Christopher D., D’Orazio, Paul, Eisenhofer, Graeme, Ellervik, Christina, Florkowski, Christopher M., Forbes, Betty A., Fraser, Callum G., Fraser, William D., Freedman, Danielle B., Genzen, Jonathan R., George, Tracy I., Gettings, Katherine B., Glasziou, Paul, Goetze, Jens Peter, Grant, Russell P., Grebe, Stefan, Green, Ralph, Gronowski, Ann M., Guder, Walter G., Hage, David S., Halsall, David, Haverstick, Doris M., Hawker, Charles D., Heaton, Phillip, Higgins, Russell A., Hilmarsdóttir, Ingibjörg, Holstege, Chris, Hoofnagle, Andrew N., Hoon, Dave, Horowitz, Gary, Horvath, Andrea Rita, Howe, John Greg, Humphries, Romney M., Jaffe, Allan S., Jones, Graham R.D., Jones, Patricia M., Jungheim, Emily, Kelley, Todd W., Kitchen, Steve, Kricka, Larry J., Kushnir, Mark M., Lamb, Edmund J., Landers, James P., Langman, Loralie J., Laterza, Omar, Lau, Anna F., Lianidou, Evi, Liesman, Rachael M., Linnet, Kristian, Lo, Stanley F., Lo, Y.M. Dennis, Longo, Nicola, Mackay, Mark, Makrigiorgos, G. Mike, Manis, John P., Mardis, Elaine R., Marshall, William J., McCormack, Ann, McMillin, Gwendolyn A., Meier, Brenton M., Miller, W. Greg, Milone, Michael C., Moons, Karel G.M., Nerenz, Robert D., Nieuwesteeg, Michelle, Nikolac, Nora, Nolte, Frederick S., Panteghini, Mauro, Park, Jason Y., Pasquali, Marzia, Patel, Jay L., Patel, Robin, Podini, Daniele S., Pratt, Victoria M., Price, Christopher P., Pritt, Bobbi S., Quillen, Karen, Rappold, Brian A., Rashidi, Hooman H., Remaley, Alan T., Rifai, Nader, Roberts, Norman B., Rockwood, Alan L., Rosenberg, William, Sacks, David B., Sandberg, Sverre, Sardh, Eliane, Sarno, Mark J., Schindler, Emily I., Schuetz, Audrey N., Scott, Mitchell G., Sethi, Amar A., Shapiro, Howard M., Shaw, Leslie M., Sherwood, Roy A., Simundic, Ana-Maria, Sodi, Ravinder, St John, Andrew, Stout, Molly, Strathmann, Frederick G., Sturgeon, Catharine, Swinkels, Dorine W., Tanwar, Sudeep, Taylor, Andrew, Thatcher, Stephanie A., van Solinge, Wouter W., van Wijk, Richard, Vaught, Jim, Vnencak-Jones, Cindy L., Wadelius, Mia, Walsham, Natalie E., Warnick, G. Russell, Weedn, Victor W., Wells, David A., Wengenack, Nancy L., Whatley, Sharon D., Winter, William E., Wittwer, Carl T., Yarbrough, Melanie L., and Zhang, Qian-Yun

Published
2018
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232. Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients

Author

Uijtendaal, Esther V, Zwart-van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, Egberts, Toine C G, Uijtendaal, Esther V, Zwart-van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, and Egberts, Toine C G

Abstract

INTRODUCTION: Tight glucose control therapy (TGC) has been implemented to control hyperglycemia in ICU patients. TGC may also influence serum potassium concentrations. We therefore investigated the influence of TGC on both serum glucose and serum potassium concentrations and associated mortality.METHOD: We performed a retrospective analysis including all patients admitted to the ICU of a tertiary hospital for 24 hours or more and with at least three serum glucose and serum potassium concentrations between 1999-2001 (conventional period), 2002-2006 (implementation period) or 2007-2009 (TGC period). Segmented regression analysis was used to estimate changes in outcomes that occurred after the intervention controlling for pre-intervention trends. Means and standard deviations (SDs) of serum glucose and serum potassium concentrations, and rate of severe hypoglycemia (≤ 2.2 mmol/L) and hypokalemia (≤ 3 mmol/L), were compared between the TGC and conventional period.RESULTS: Although mean serum glucose concentrations dropped 2.1 mmol/L (95% CI =-1.8 to -2.3 mmol/L, p<0.002), mean serum potassium concentrations did not change (absolute increase 0.02 mmol/L; 95% CI = -0.06 to 0.09 mmol/L, p=0.64). The rate of severe hypoglycemia increased with 5.9% (95% CI=-3.0 to -8.9, p<0.002), but the rate of hypokalemia remained equal (absolute reduction 4.8%; 95% CI = -11.1% to 1.5%, p=0.13). The SD of serum glucose concentrations within a patient did not change, while the SD of serum potassium concentrations even decreased 0.04 mmol/L (95% CI = -0.01 to -0.07, p = 0.01). ICU mortality decreased but this decrease was not significant (absolute difference -3.63%; 95% CI = -9.33 to 2.09, p = 0.20). Mean serum glucose concentrations, mean serum potassium concentrations and SDs of both serum glucose and serum potassium concentrations were all independently associated with ICU mortality. Highest mortality rates were seen at both the lowest and highest mean values (U/J-s

Published
2015

233. Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction

Author

van Hout, Gerardus P J, Teuben, Michel P J, Heeres, Marjolein, de Maat, Steven, de Jong, Renate, Maas, Coen, Kouwenberg, Lisanne H J A, Koenderman, Leo, van Solinge, Wouter W, de Jager, Saskia C A, Pasterkamp, Gerard, Höfer, IE, van Hout, Gerardus P J, Teuben, Michel P J, Heeres, Marjolein, de Maat, Steven, de Jong, Renate, Maas, Coen, Kouwenberg, Lisanne H J A, Koenderman, Leo, van Solinge, Wouter W, de Jager, Saskia C A, Pasterkamp, Gerard, and Höfer, IE

Published
2015

234. Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis

Author

van Zwieten, Rob, van Oirschot, Brigitte A, Veldthuis, Martijn, Dobbe, Johannes G, Streekstra, Geert J, van Solinge, Wouter W, Schutgens, Roger E G, van Wijk, Richard, van Zwieten, Rob, van Oirschot, Brigitte A, Veldthuis, Martijn, Dobbe, Johannes G, Streekstra, Geert J, van Solinge, Wouter W, Schutgens, Roger E G, and van Wijk, Richard

Published
2015

235. Hematological Parameters Improve Prediction of Mortality and Secondary Adverse Events in Coronary Angiography Patients : A Longitudinal Cohort Study

Author

Gijsberts, Crystel M, den Ruijter, Hester M, de Kleijn, Dominique P V, Huisman, Albert, ten Berg, Maarten J, van Wijk, Richard H A, Asselbergs, Folkert W, Voskuil, Michiel, Pasterkamp, Gerard, van Solinge, Wouter W, Hoefer, Imo E, Gijsberts, Crystel M, den Ruijter, Hester M, de Kleijn, Dominique P V, Huisman, Albert, ten Berg, Maarten J, van Wijk, Richard H A, Asselbergs, Folkert W, Voskuil, Michiel, Pasterkamp, Gerard, van Solinge, Wouter W, and Hoefer, Imo E

Published
2015

236. Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis : Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms

Author

Bartels, M, van der Zalm, M.M., van Oirschot - Hermans, B.A., Lee, Frank S., Giles, R, Kruip, Marieke J. H. A., Gitz-Francois, Jerney J. J. M., Van Solinge, Wouter W., Bierings, MB, van Wijk, Richard, Bartels, M, van der Zalm, M.M., van Oirschot - Hermans, B.A., Lee, Frank S., Giles, R, Kruip, Marieke J. H. A., Gitz-Francois, Jerney J. J. M., Van Solinge, Wouter W., Bierings, MB, and van Wijk, Richard

Published
2015

239. Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients

Author

Dep Farmaceutische wetenschappen, Sub Pharmacotherapy, Theoretical, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Uijtendaal, Esther V, Zwart-van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, Egberts, Toine C G, Dep Farmaceutische wetenschappen, Sub Pharmacotherapy, Theoretical, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Uijtendaal, Esther V, Zwart-van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, and Egberts, Toine C G

Published
2015

240. Adherence with Dosing Guideline in Patients with Impaired Renal Function at Hospital Discharge

Author

Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Drenth-van Maanen, A Clara, van Marum, Rob J, Jansen, Paul A F, Zwart, Jeannette E F, van Solinge, Wouter W, Egberts, Toine C G, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Drenth-van Maanen, A Clara, van Marum, Rob J, Jansen, Paul A F, Zwart, Jeannette E F, van Solinge, Wouter W, and Egberts, Toine C G

Published
2015

241. Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients

Author

Apotheek Bereidingen, Apotheek Klinische Farmacie, Medische Staf Intensive Care, Apotheek Opleiding, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Apotheek, Uijtendaal, Esther V, van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, Egberts, Toine C G, Apotheek Bereidingen, Apotheek Klinische Farmacie, Medische Staf Intensive Care, Apotheek Opleiding, Centraal Diagnostisch Laboratorium, Infection & Immunity, Circulatory Health, Apotheek, Uijtendaal, Esther V, van Rijkom, Jeannette E F, de Lange, Dylan W, Lalmohamed, Arief, van Solinge, Wouter W, and Egberts, Toine C G

Published
2015

242. Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis

Author

Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Nanomedicine, van Zwieten, Rob, van Oirschot, Brigitte A, Veldthuis, Martijn, Dobbe, Johannes G, Streekstra, Geert J, van Solinge, Wouter W, Schutgens, Roger E G, van Wijk, Richard, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Nanomedicine, van Zwieten, Rob, van Oirschot, Brigitte A, Veldthuis, Martijn, Dobbe, Johannes G, Streekstra, Geert J, van Solinge, Wouter W, Schutgens, Roger E G, and van Wijk, Richard

Published
2015

243. Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction

Author

Experimentele Afd. Cardiologie 1, Zorgeenheid Traumatologie, CDL Contact activatie, Experimentele Afdeling Longziekten, Cancer, Centraal Diagnostisch Laboratorium, Circulatory Health, Cardiovasculaire Immunologie, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, van Hout, Gerardus P J, Teuben, Michel P J, Heeres, Marjolein, de Maat, Steven, de Jong, Renate, Maas, Coen, Kouwenberg, Lisanne H J A, Koenderman, Leo, van Solinge, Wouter W, de Jager, Saskia C A, Pasterkamp, Gerard, Höfer, IE, Experimentele Afd. Cardiologie 1, Zorgeenheid Traumatologie, CDL Contact activatie, Experimentele Afdeling Longziekten, Cancer, Centraal Diagnostisch Laboratorium, Circulatory Health, Cardiovasculaire Immunologie, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, van Hout, Gerardus P J, Teuben, Michel P J, Heeres, Marjolein, de Maat, Steven, de Jong, Renate, Maas, Coen, Kouwenberg, Lisanne H J A, Koenderman, Leo, van Solinge, Wouter W, de Jager, Saskia C A, Pasterkamp, Gerard, and Höfer, IE

Published
2015

244. Hematological Parameters Improve Prediction of Mortality and Secondary Adverse Events in Coronary Angiography Patients: A Longitudinal Cohort Study

Author

Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Nanomedicine, Cardiologie, Centraal Diagnostisch Laboratorium, CDL Staf Research, CDL Arcadia, Gijsberts, Crystel M, den Ruijter, Hester M, de Kleijn, Dominique P V, Huisman, Albert, ten Berg, Maarten J, van Wijk, Richard H A, Asselbergs, Folkert W, Voskuil, Michiel, Pasterkamp, Gerard, van Solinge, Wouter W, Hoefer, Imo E, Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), CDL Nanomedicine, Cardiologie, Centraal Diagnostisch Laboratorium, CDL Staf Research, CDL Arcadia, Gijsberts, Crystel M, den Ruijter, Hester M, de Kleijn, Dominique P V, Huisman, Albert, ten Berg, Maarten J, van Wijk, Richard H A, Asselbergs, Folkert W, Voskuil, Michiel, Pasterkamp, Gerard, van Solinge, Wouter W, and Hoefer, Imo E

Published
2015

245. Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms

Author

Haematologie patientenzorg, Centraal Diagnostisch Laboratorium, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Infection & Immunity, Haematologie, Child Health, CDL Nanomedicine, Bartels, M, van der Zalm, M.M., van Oirschot - Hermans, B.A., Lee, Frank S., Giles, R, Kruip, Marieke J. H. A., Gitz-Francois, Jerney J. J. M., Van Solinge, Wouter W., Bierings, MB, van Wijk, Richard, Haematologie patientenzorg, Centraal Diagnostisch Laboratorium, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Infection & Immunity, Haematologie, Child Health, CDL Nanomedicine, Bartels, M, van der Zalm, M.M., van Oirschot - Hermans, B.A., Lee, Frank S., Giles, R, Kruip, Marieke J. H. A., Gitz-Francois, Jerney J. J. M., Van Solinge, Wouter W., Bierings, MB, and van Wijk, Richard

Published
2015

246. Adherence with dosing guideline in patients with impaired renal function at hospital discharge

Author

MS Geriatrie, Apotheek Klinische Farmacie, Centraal Diagnostisch Laboratorium, Apotheek, Drenth-van Maanen, Clara, Van Marum, Rob J., Jansen, Paul A F, Zwart-van Rijkom, JEF, Van Solinge, Wouter W., Egberts, Toine C G, MS Geriatrie, Apotheek Klinische Farmacie, Centraal Diagnostisch Laboratorium, Apotheek, Drenth-van Maanen, Clara, Van Marum, Rob J., Jansen, Paul A F, Zwart-van Rijkom, JEF, Van Solinge, Wouter W., and Egberts, Toine C G

Published
2015

247. When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy

Author

LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Other research (not in main researchprogram), Oostendorp, Marlies, Lammerts Van Bueren, Jeroen J., Doshi, Parul, Khan, Imran, Ahmadi, Tahamtan, Parren, Paul W H I, Van Solinge, Wouter W., De Vooght, Karen M K, LKCH Staf Patiëntenzorg, Centraal Diagnostisch Laboratorium, Infection & Immunity, Other research (not in main researchprogram), Oostendorp, Marlies, Lammerts Van Bueren, Jeroen J., Doshi, Parul, Khan, Imran, Ahmadi, Tahamtan, Parren, Paul W H I, Van Solinge, Wouter W., and De Vooght, Karen M K

Published
2015

250. Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-linede novomutation

Author

Mañú-Pereira, María Del Mar, primary, Gonzalez-Roca, Eva, additional, van Solinge, Wouter W., additional, Llaudet-Planas, Esther, additional, Sevilla, Julián, additional, Montllor, Laura, additional, Mensa-Vilaro, Anna, additional, Ploos van Amstel, Hans Kristian, additional, van Wijk, Richard, additional, and Vives-Corrons, JoanLluis, additional

Published
2015
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