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Precipitation is an important component in the climate system and plays a key role in water resources protection, drought and flood prevention. Innovation Trend Analysis (ITA) method, R/S method, maximum entropy spectrum analysis and wavelet analysis were used to study the evolution characteristics of the Yellow River Delta annual precipitation from 1954 to 2014. The results suggest that the precipitation series changed significantly and showed an overall downward trend, and may show an upward trend in the future, which is relatively strong. There are three-time scales of annual precipitation variation: 20-32a, 8-18a, and 3-6a. The quasi-27 year was the main oscillation period of the average annual precipitation in the Yellow River Delta, the secondary major period was 13 years, and the small-scale oscillation period was 5 years. Precipitation changed suddenly in 1980 and 2003. In contrast, there was no significant mutation point in 2002-2014.

The current study is an endeavour to measure the bioaccumulation potentials of heavy metals in different parts of chilli plants (Capsicum annuum L.) grown in artificially contaminated soil with various concentrations of Cr and Pb. The concentrations of heavy metals were estimated by Atomic Absorption Spectroscopy (AAS) technique. The mean concentration of Cr and Pb accumulated in different parts of plants in high, medium, and low levels of contamination was in the following order: roots > leaves > shoots > fruits. Cr concentration in fruits was lower than that of the WHO standard. However, fruits grown on medium contaminated soil contained 0.695 mg/kg Cr which did not follow the safe guideline by SEPA. A significant amount of Pb was traced in fruits grown in highly contaminated soil that exceeded the standard limit set by FAO/WHO. Accumulation of Pb was higher than Cr at different levels of contamination in every part of the chilli plants. The transfer factor for Cr and Pd was found in the following order, leaves > shoots > fruits> roots and leaves > shoots > roots > fruits, correspondingly at every level of contamination. The bioconcentration factors were higher in Pb than Cr. The daily intake of metals in combination with health and carcinogenic risk indexes indicated that the edible parts of chilli plants are safe to consume as recommended by SEPA/WHO/FAO. The present study can be considered a reference for assessment and monitoring of heavy metals associated with human health risks in chilli plants at different industrially contaminated sites.

Graphical abstract, Introduction Hard coatings are primarily based on carbides, nitrides and carbonitrides of transition metal elements such as W, Ti, Zr, etc. Zr-based hard coatings show good resistance to wear, erosion, and corrosion as well as exhibit high hardness, high temperature stability, and biocompatibility, making them suitable candidates for tribological, biomedical, and electrical applications. Objectives The present study aims to synthesize uniform and adherent hard Zr-based coatings that demonstrate sound mechanical integrity. Methods Stainless steel (SS316) samples were coated with single layers of Zr, Zr-nitride, and Zr-carbonitride using magnetron sputter deposition technique. Deposition conditions were controlled to produce each coating with two different thickness i.e., 2 and 3 μm. Calotest was employed to confirm coatings thickness. Scanning electron microscope fitted with energy dispersive x-ray spectrometer was used to ascertain the morphology and elemental constitution of coatings. Cross-sectional samples were examined to ascertain coatings thickness and adhesion. X-ray diffractometer was employed for structural analysis. Instrumented nanoindentation hardness and elastic modulus were determined with nanoindenter. Ratio of nanohardness to elastic modulus was evaluated to observe the effect of coatings thickness on tribological behavior. Results Three coating compositions were produced namely hcp-Zr, fcc-ZrN and fcc-Zr2CN. The highest hardness and elastic modulus were shown by ZrN coatings while pure Zr coatings showed the lowest values. Conclusion All coating compositions were found to be relatively uniform, continuous and adherent with no evidence of decohesion at the coating-substrate interface. Coatings produced in this study are thought to be suitable for tribological applications.

Teucrioside, 9′-decarboxyrosmarinic acid 4′-O-α-rhamnosyl-(1‴→6‴)-O-β-galactosyl-(1‴→4″)-Oα-rhamnoside is a natural phenolic compound. It has been isolated and identified from the genus Teucrium. Teucrium genus is widely used in traditional medicine for its antioxidant, diuretic, antiulcer, antitumor, anti-inflammatory, antispasmodic and antibacterial properties. Since silver nanoparticles have superior physicochemical properties, they have an important role in biology and medicine. In this study, the biosynthesis of silver nanoparticles was carried out using Teucrioside and AgNO3. The effect of five independent variables (pH, AgNO3 concentration, Teucrioside volume/total volume, microwave power and time) on nanoparticle formation was evaluated using a central composite design (CCD) based response surface methodology (RSM). Nanoparticle formation was demonstrated by UV-Vis spectroscopy and FTIR analysis. The particle size and zeta potential of silver nanoparticles were determined by dynamic light scattering method (DLS). The results showed that 5 mM AgNO3, Teucrioside volume/total volume:0.3, 475 watt, 60 sec. and pH:7.5 were optimal reaction parameters. The antibacterial activity of biosynthesized silver nanoparticles was tested against common pathogens such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumonia. Obtained results demonstrated that biosynthesized silver nanoparticles from Teucrioside have great potential as a new antibacterial agent.

Intending to remove toxic graphene oxide (GO) from wastewater, LDH (layered double hydroxide) was employed to recover GO by adsorption method. The adsorption performance and the mechanism of LDH for GO have been systematically studied by diverse characterization technologies and methods. The relevant effects of solution pH (2-9), absorbent dosage (5-25mg) and the concentration of GO (20-160mg/L) were investigated in detail. The main driving force of GO condensation on LDH may be electrostatic interaction and hydrogen bonding, SEM, TEM, AFM, FT-IR and XRD analysis further confirmed this. XPS test shows that the adsorption process is carried out through C−O and O−C=O. We have got a high removal rate of 92% and an adsorption capacity of 1472 mg/g under an optimized conditions (pH = 3.0, equilibrium time = 6.0 h, dosage = 10mg, C0 = 160 mg/L). The analyses implied that LDH will be a very promising candidate for recovery of GO from wastewater.

Ushbu maqoladada STEAM ta`lim tizimi nima va uning vazifalari, samaradorligi, qanday ta`lim sohalarda qo’llash mumkinligi haqida ma`lumot beriladi. Davomida esa, bu ta`lim tizimida xorijiy tillarnni o’qitilsa qanday natija bo’lishi haqida qisqacha tushunchalar berilgan.

Oʻrta va katta quvvatli elektr yuritmalar uchun tiristorli oʻzgartkich uzlukli tok zonasining arzimas boʻlishi sababli oʻzgartkichning bu tok rejimi amaliyotda koʻpincha hisobga olinmaydi. Ammo kuzatuvchi elektr yuritma tizimlarida, yaʼni boshqaruv kichik signallar asosida boshqariladigan tiristorli oʻzgartkichli elektr yuritmalarda uzlukli tok rejimini hisobga olish zarurdir.

In this paper, a new copula model with given unit marginals is proposed, based on Rüschendorf’s Method. A new bivariate copula family is introduced by adding a proper term to independence copula. Thus, we avoid the complexity of the proposed copula model. By choosing a baseline copula from the same marginal, we derive a new copula that can approach from above towards the independence copula. Furthermore, it is established that a bivariate copula constructed by this method allows some flexibility in the dependence measure according to Spearman’s correlation coefficient. Additionally, tail dependence measures are investigated. Illustrative examples are given taking into account the specific choices of a baseline copula.

Bizga ma’lumki maktabgacha ta’lim muassasalari uzluksiz ta’limning asosiy negizini tashkil etadi. Mustaqillik yillarida malakali tarbiyachi va pedagog kadrlarni ustuvor ravishda tayorlashda alohida e’tibor berilishi natijasida uning samaradorligi oshdi. Maktabgacha ta’lim dasturlari qayta ishlandi. Zamonaviy o’quv – uslubiy qo’llanmalar texnik vositalar o’yinchoqlar ishlab chiqildi. Maktabgacha yoshdagi bolalarning aqliy, ruxiy, jismoniy, shaxsiy, madaniy rivojlanishiga alohida e’tibor qaratildi. Maktabgacha yoshdagi bolalarning milliy va umuminsoniy qadriyatlar asosida ma’naviy – axloqiy jihatdan tarbiyalash uchun pedagogik shart sharoitlar yaratildi. Ilmiy – tadqiqot ishlari amalgam oshirildi.

Ушбу мақолада пахта тозалаш корхоналаридан чиқаётган чангли ҳаво устида олиб борилган амалий тажриба натижалари ва таркибидаги чанг заррачаларининг фракцион таркиби таҳлили келтирилган.

В образовательном сообществе резко возросло использование информационных и коммуникационных технологий (ИКТ) в преподавании и изучении иностранных языков. Учителя получают доступ к инновациям и внедряют их, не всегда осознавая их значение для них и своих учеников. Однако это не обязательно отрицательно, потому что, если бы никто не использовал инновации, прогресс был бы небольшой, и оценивать было бы нечего. В статье представлены некоторые особенности ИКТ, которые можно использовать с пользой в богатой учебной среде, а также использование видео в качестве инструмента ИКТ на уроках иностранного языка. В документе также обсуждается роль учителя во внедрении технологий, и мы утверждаем, что именно учитель, а не технология, определяет качество обучения и преподавания. Есть люди, которые опасаются, что роль учителя будет поставлена ​​под угрозу, если мы интегрируем информационно-коммуникационные технологии в образование; однако мы выступаем за «техно гуманистическую» систему, в которой учителя, учащиеся и технологии образуют прочный и значимый союз.

Graphical abstract, Introduction The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter receptors is essential for synaptic function. In case of GlyRs, only beta subunits were known until now to mediate synaptic anchoring. Objectives We identified a poly-proline II helix (PPII) in position 365–373 of the intra-cellular TM3-4 loop of the human GlyRα1 subunit as a novel potential synaptic anchoring site. The potential role of the PPII helix as synaptic anchoring site was tested. Methods Glycine receptors and collybistin variants were generated and recombinantly expressed in HEK293 cells and cultured neurons. Receptor function was assessed using patch-clamp electrophysiology, protein-protein interaction was studied using co-immuno-precipitation and pulldown experiments. Results Recombinantly expressed collybistin bound to isolated GlyRα1 TM3-4 loops in GST-pulldown assays. When the five proline residues P365A, P366A, P367A, P369A, P373A (GlyRα1P1-5A) located in the GlyRα1-PPII helix were replaced by alanines, the PPII secondary structure was disrupted. Recombinant GlyRα1P1-5A mutant subunits displayed normal cell surface expression and wildtype-like ion channel function, but binding to collybistin was abolished. The GlyRα1-collybistin interaction was independently confirmed by o-immunoprecipitation assays using full-length GlyRα1 subunits. Surprisingly, the interaction was not mediated by the SH3 domain of collybistin, but by its Pleckstrin homology (PH) domain. The mutation GlyRα1P366L, identified in a hyperekplexia patient, is also disrupting the PPII helix, and caused reduced collybistin binding. Conclusion Our data suggest a novel interaction between α1 GlyR subunits and collybistin, which is physiologically relevant in vitro and in vivo and may contribute to postsynaptic anchoring of glycine receptors.

Мақолада кичик бизнес молиясини бошқариш тизимининг ҳозирги замон хусусиятлари ва муаммолари корпоратив молия нуқтаи-назаридан кўриб чиқилган. Рақобатли бозор иқтисодиётига ўтиш жараёнларини тезлаштириш ва иқтисодиётда хусусий секторни жадал ривожлантириш устуворлиги кичик бизнес молиясини бошқариш тизимини такомиллаштиришнинг концептуал асосларини яратишни талаб этади.

Graphical abstract, Introduction Luffa aegyptiaca Mill, sponge gourd or Egyptian cucumber, is grown worldwide for its edible fruit consumed as a vegetable like cucumber. Unlike young fruit (YF), the fully mature ripened fruit (MF) is strongly fibrous and is used as a cleanser to make scrubbing bath sponges. YF undergoes a complex series of physiological and biochemical changes during fruit ripening. However, the chemical compositional differences between YF and MF in Luffa aegyptiaca have not been distinguished to date. Objectives Comprehensively compare the metabolites profile of YF and MF to give insight on how maturation stage affects chemical composition. Methods Mass-based metabolomics comprising GC/MS and UHPLC/MS were adopted in this study targeting its volatile and non-volatile metabolites coupled with chemometrics to rationalize for the differences. Results A total of 53 volatile metabolites were identified via headspace solid phase microextraction (SPME) comprising 66.2% aldehydes/furans, 51.6% alcohols, 38.2% ketones, 15.1% acids and 10.1% aromatics of which aldehydes/ furans were dominant at both fruit stages. Young fruit was in general more erniched in metabolites as revealed from UHPLC/MS and GC/MS analyses. The YF group encompassed higher levels of short chain alcohols (1-octen-3-ol) and aldehydes ((E)-2-hexenal and cucumber aldehyde) in addition to terpenoids (linalool). In contrast, fatty acids (octanoic acid) predominated MF specimens. UHPLC/MS analysis revealed for several oleanene triterpene glycosides as major secondary bioactive compounds, dihydroxy-oxo-oleanenoic acid glycoside found more abundant in YF versus MF as revealed from multivariate data analyses. Conclusions Our results reveal for the distinct metabolite changes in L. aegyptiaca fruit in its different stages and to rationalize for its different usage.

The long-term use of sewage to irrigate farmland will increase the content of heavy metals in the soil and cause soil pollution. Heavy metal pollution in soils will restrict the sustainable development of local agriculture and will have a negative impact on the ecological environment. In this paper, the irrigation areas using domestic sewage, mixed sewage and industrial sewage as an irrigation water source for many years have been selected as the research objects, and the content of the heavy metals lead (Pb), copper (Cu), zinc (Zn) and cadmium (Cd) in the soil with the depth of 0-20cm, 20-50cm and 50-80cm of three kinds of sewage irrigation areas are assessed using single factor pollution index method and Nemerow comprehensive index method, and the potential ecological risks of heavy metals in the soil are assessed using Hakanson ecological risk index method. The results show that the content of heavy metals Pb, Cu, Zn and Cd in different depths of the three sewage irrigation areas does not exceed the national standard limit, and the heavy metal pollution grade in the soil belongs to the safety grade, indicating that the content of heavy metals in the soil has not reached the alert level. The potential ecological risks of heavy metals in the soil show minor ecological risks judging from single indexes, while Cd shows that the ecological risks are at a strong level. Judging from the comprehensive potential ecological risk index, the potential ecological risks of the heavy metals in the study area is minor in graded, but the heavy metals in the soil of the mixed sewage irrigation area and the industrial sewage irrigation area have a moderate grade of potential ecological risks at the depth of 50-80 cm. Therefore, although the content of the heavy metals in the soil of the three kinds of sewage irrigation areas in the study area is safe, the potential ecological risk of Cd is quite high, which should be paid attention to.

Texnika va texnologiya jadal rivojanayotgan bir vaqtda fan, sanoat va ishlab chiqarishni axborot kommunilatsion texnologiyalarsiz tasavvur etib bo’lmaydi. Ayniqsa xar bir fanni o’qitishda ushbu axborot kommunilatsion texnologiyalardan foydalanish talabalarning fanga bo’lgan qiziqishini oshiribgina qolmay, balki mavzularni chuqur o’zlashtirishga, yangicha go’yalarni shakllantirishga asos bo’ladi. Kimyo fanida ham AKTni ta’lim tizimiga jalb qilish, o’qitishning yangicha uslublarini qo’llash imkoniyatlari yoritilgan.

Uranium (U) is a common radionuclide in soil and groundwater. Uranium contamination often results from uranium mining and processing, nuclear energy power plants, nuclear weapon tests and nuclear accidents. Due to its toxicity and bioaccumulation, it was necessary to treat it effectively. Biochar and FeS nanoparticles were prepared for the treatment of U(VI) in solution. The characteristics of biochar and FeS nanoparticles were determined by Scanning Electron Microscopy, Energy Dispersive Spectrum and Fourier Transform Infrared Spectroscopy and BET adsorption method. The results showed that a large number of functional groups were present on the surface of biochar and FeS nanoparticles. The influencing factors, such as contact time, pH of the solution, initial concentration U(VI) and solution temperature, had an important influence on the adsorption capacity of U(VI) by biochar and FeS nanoparticles.

Инсоннинг маънавий қиёфаси, айниқса, ижтимоий тарбияси оилада шаклланади. Зеро мустақиллигимиз пойдеворини мустаҳкамлайдиган, мамлакатимиздаги оламшумул аҳамиятга молик ўзгаришларни амалга оширадиган шахс хам оилада тарбияланади. Ҳар қандай тарбия, аввало оиладан бошланади.

The present study was designed to display the integrated model of nitrogen discharge process (i.e. nitrites and nitrates; ammonia; chlorophyll and dissolved nitrogen, dissolved oxygen) which is part of the complete model of shrimp aquaculture of an Integrated Shrimp Aquaculture Park (i-Sharp) ecosystem in System Dynamic Model Aquaculture-System Policy (SD-AQEP). This study offers a comprehensive elaboration concerning the long-term process of nitrogen accumulation, as well as its effects on shrimp activities. Furthermore, the analysis of the model and the simulation results also show the conditions of nitrogen with several strategies for control and manipulation. For example, in situations where mixing of stock density is high and providing feed into ponds supplies is excessive, the nitrogen dynamic rapidly hits alarming levels. Aforementioned, the typical strategy in this setting such as stocking density and the best time to harvest could be established. Additionally, the model structure represents the discharge derived from the nitrogen process on varied settings of variables in aquaculture development. In conclusion, this model provides an experimental simulation platform that can be implemented by policy makers on long-term strategic management for developing or maintaining large-scale aquaculture development projects in the future.

The object of the study: Uterine fibroids (UF) in women of early reproductive age. The problem to be solved: Improving the effectiveness of postoperative rehabilitation in women of early reproductive age with uterine fibroids based on the study of its morphological features and improvement of rehabilitation measures. The main scientific results: It was found that in women of early reproductive age with UF the most common complaints are posthemorrhagic anemia (61.0 %, or 61 women). Regarding the menstrual cycle, the most common dysmenorrhea – 26.0 % (in 26 women). The importance of heredity in the development of such pathology in young women (32.0 %, or 32 women) was confirmed. The most common localization of fibroids is interstitial – 79.0 % (in 79 women). Morphological study found that women of early reproductive age most often have a simple UF, namely 96 % (96 women). Uterine leiomyoma was present in 56 % (56 women). A study of the hormonal status of women of early reproductive age found that the mean values ​​of hormones such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, prolactin and testosterone were higher before surgery than after. When comparing rehabilitation methods (combined oral contraceptives (COCs) or gonadotropin-releasing hormone agonists (GnRH agonists), it was found that postoperative rehabilitation by using COCs for 6-12 months provides significantly better indicators of recovery of hormonal status, indicating the effectiveness of rehabilitation method. Scope of practical application of research results: Practical medicine specializing in the diagnosis, treatment and prevention of recurrence of uterine fibroids. Innovative technological product: Improved algorithm of postoperative rehabilitation measures by applying COC for 6-12 months after myomectomy, which provides significantly better results in restoring hormonal status during rehabilitation. Scope of application of innovative technological product: clinical medical practice related to the diagnosis, treatment and prevention of recurrence of uterine fibroids.

Penelitian ini bertujuan menerapkan model pembelajaran Curious Note Program (CNP) untuk meningkatkan keterampilan berpikir kritis peserta didik. Jenis penelitian yang digunakan adalah pre-experimental dengan menggunakan one group pre-test post-test design . Populasi yang digunakan dalam penelitian ini adalah peserta didik kelas X MIPA SMAN 1 Wonoayu dengan menggunakan dua kelas sebagai sampel, yaitu kelas X MIPA 6 sebagai kelas eksperimen dan kelas X MIPA 7 sebagai kelas replikasi. Sampel yang digunakan menggunakan teknik simple random sampling dengan memberikan peluang yang sama bagi setiap populasi untuk dipilih menjadi sampel secara acak. Instrumen penelitian berupa lembar pengamatan keterlaksanaan pembelajaran dan tes keterampilan berpikir kritis yang diberikan kepada peserta didik untuk mendapatkan data penelitian. Teknik analisis data yang digunakan yaitu deskriptif kuantitatif untuk keterlaksanaan pembelajaran, uji normalitas untuk mengetahui kategori terdistribusi normal, uji homogenitas untuk mengetahui kedua kelas homogen, uji t-berpasangan untuk menguji perbedaan nilai pre-test dan post-test, dan analisis n-gain untuk mengetahui peningkatan keterampilan berpikir kritis peserta didik. Kesimpulan dari penelitian yang telah dilakukan adalah keterlaksanaan model pembelajaran Curious Note Program (CNP) dikategorikan sangat baik dan dapat meningkatkan keterampilan berpikir kritis pada kategori sedang untuk kedua kelas.

The object of research: the procedural order of fiscal and accounting regulation of revenues from export agricultural products (export receipts, the export duty). Investigated problem: obtaining stable and repetitive connection between the accounting part, the fiscal part of the regulation and exports of agricultural goods with possibility of improvement. The main scientific results: it is revealed that the first stage of fiscal-accounting regulation of exported agricultural products is transactions’ accounting on accounts. It should be noted that, after the abolition of the mandatory sale in Ukraine, there is no need to apply the distributive account in export of agricultural products. It will help to reduce the time of enrollment the currency and its using by exporters for their needs. It is determined too, that the second stage of the regulation is the export receipts and revenues from the export duty. Moreover, using economic (mathematical) modeling, based on correlation-regression analysis, it is illustrated positive effects for reducing of export duty rates on revenues from export agricultural products in Ukraine. The area of practical use of the research results: Government of Ukraine in formation of export strategy, and exporters – in the context of accounting. Innovative technological product: the regulation technology of the cyclical accounting and fiscal parts in agricultural exports with using modeling econometric analysis for determination of direction of its development. Scope of the innovative technological product: Ukraine’s Government practice in using mathematic modeling for determination of trends of agricultural exports.

Object of research: degradation processes occurring in the blades of a gas-pumping unit (GPU) during its long-term operation and cause the appearance of defects that lead to a change in their technical condition and breakage of the working blades and, as a result, to accidents. Solved problem: obtaining a method for diagnosing the GPU blades, which can be used to determine its technical condition during the GPU operation. The main scientific results: a classification of methods for diagnosing the GPU blades and their analysis was developed, according to the results of which it was established that the improvement of a new method of aerodynamic calculation of profiles relative to the GPU blades by developing mathematical models of the deformation process and flow around the GPU blades and calculation formulas for assessing their aerodynamic characteristics, will allow to simulate possible options for changing the technical state of the blades (the amount of wear of the blades, their number, deformation, etc.), to study their influence on the parameters of the oscillatory processes of the blades and to compile a dictionary (base) of diagnostic signs of their state. The use of such a base will make it possible to quickly determine the technical condition of the blades during the GPU operation and prevent the occurrence of emergency situations The area of practical use of the research results: the enterprises of the gas transmission system, which operate GPU with a gas turbine drive An innovative technological product: a method of direct aerodynamic calculation of airfoils relative to GPU blades to determine their technical condition during operation. Scope of application of the innovative technological product: gas-pumping units with a gas turbine drive with a capacity of 6.3 MW to 25.0 MW

This paper aimed to design an autonomous indirect solar dryer, which can dehydrate the aguaymanto in a costeffective manner, yielding a quality product suitable for export from the central part highland of Peru. To complete this task, it was proposed to design a prototype of autonomous solar dryer of 100 kg per batch of aguaymanto, equipped with flat reflectors and forced air feed, and powered with photovoltaic energy. This system allows to dry aguaymanto fruit at the requirements needed for its exportation. The fryer has the following dimensions: inner dimensions of the drying chamber: bottom 0.60 m, width 1.40 m, and height 1.10 m, with additional 0.05 m for insulation. Hence, the outer measures are bottom 0.70 m, width 1.50 m, and height 1.20 m. Two solar collectors are proposed with the dimensions of each: 1.50 m wide, 2.40 m long, and 0.15 m height; 2 flat mirror reflectors are required. A 80 Wp photovoltaic panel was selected for the forced air system and process control. This solar dryer is expected to cope with the problem of post-harvest deterioration. Also, it will facilitate the export by improving product quality and providing a cost-effective technology.

La evaluación de metales pesados en la leche puede considerarse como indicador de contaminación ambiental de un lugar, por lo que el objetivo de la investigación fue determinar la presencia de plomo, mercurio y arsénico en leche cruda de Machachi, Provincia de Pichincha-Ecuador. Se recolectaron 58 muestras provenientes de 29 fincas lecheras con sistema de pastoreo extensivo y ubicadas hasta máximo un kilómetro a la redonda del Municipio de Machachi, donde existe actividad industrial y está cerca de la Panamericana Sur. Las muestras fueron analizadas mediante la técnica de espectrofotometría de absorción atómica por generador de hidruros (mercurio y arsénico) y con horno de grafito (plomo). Todas las muestras analizadas mostraron niveles de plomo, con una media de 0,208 mg kg1 (rango entre 0,0016 a 0,719 mg kg1), de las cuales el 98,28% (57/58) contienen niveles superiores a los máximos permitidos por la NTE INEN 9 de 0,02 mg kg1. También se detectó mercurio y arsénico en cuatro y dos muestras de leche, respectivamente, encontrándose en el primer caso en una media de 0,00009 mg kg1 (rango entre 0,00 a 0,002 mg kg1) y en el segundo caso un promedio de 0,00003 mg kg1 (0,00 a 0,001 mg kg1), y aunque los niveles son muy bajos, los mismos son bastante preocupantes ya que son capaces de acumularse y ser potencialmente cancerígenos. Con los resultados obtenidos, se concluye que se ha detectado contaminación por plomo en el área estudiada, pero sobre todo por dos sustancias altamente tóxicas (arsénico y mercurio), para lo cual es necesario un monitoreo continuo en la leche, y sobre todo para buscar posibles fuentes de contaminación.// The presence of heavy metals in milk is an indicator of local environmental contamination. The objective of this investigation was to test raw milk from Machachi, Pichincha Province, Ecuador for the presence of lead, mercury, and arsenic. Fifty eight samples were collected from twenty nine dairy farms with extensive grazing systems located up to one kilometer from the Municipality of Machachi. Machachi is a site of industrial activity and is located near the Panamericana Sur highway. The samples were analyzed using atomic absorption spectrophotometry with a hydride generator (mercury and arsenic) and a graphite furnace (lead). All analyzed samples indicated the presence of lead, with an average abundance of 0.208 mg kg1 (range between 0.0016 to 0.719 mg kg1). Of these samples, 98.28% (57/58) contained lead at levels higher than the maximum allowed by the NTE INEN 9, 0.02 mg kg1. Mercury was detected in four samples with a mean abundance of 0.00009 mg kg1 (range between 0.00 to 0.002 mg kg1); and arsenic was detected in two samples with a mean abundance of 0.00003 mg kg1 (0.00 to 0.001 mg kg1). Although these levels are very low, they remain worrisome because these carcinogenic elements are capable of accumulating. Based on these results, it can be concluded that lead contamination has occurred in the studied area. Furthermore, the detection of arsenic and mercury, two highly toxic substances, warrants continuous monitoring of the regional milk supply and a search for possible sources of contamination.

La predicción de niveles de agua en ríos es importante para prevenir pérdidas económicas así como de vidas humanas causadas por inundaciones. Los modelos hidráulicos son comúnmente usados para predecir estos niveles de agua y tomar acciones para mitigar el daño debido a inundaciones. En la presente investigación, se analizó una aproximación 2D para resolver las ecuaciones promediadas en profundidad de Reynolds Average Navier Stokes (RANS), llamado Conveyance Estimation System (CES), para explorar sus capacidades predictivas. Este artículo presenta una ampliación del estudio realizado por Knight y col., 2009. De igual forma, en esta investigación se explora una caracterización más detallada del parámetro de rugosidad y del número de zonas de rugosidad produciendo diversos escenarios. Se evaluó el desempeño de cada escenario mediante diferentes funciones de ajuste usando curvas de descarga para comparación. La investigación muestra que el uso de una adecuada descripción de la rugosidad, como un factor de rugosidad calibrado para toda la sección transversal o un modelo de rugosidad para cantos rodados calibrado para el lecho junto con valores de rugosidad obtenidos en valores sugeridos por el CES para los bancos, produce resultados del modelo óptimos en un río de montaña.// The prediction of water levels in rivers is important to prevent economical as well as human losses caused by flooding. Hydraulic models are commonly used to predict those water levels and take actions to mitigate flooding damage. In this research, a 2D approach to solve the depth average Reynolds Average Navier Stokes (RANS) equations, called Conveyance Estimation System (CES), is analyzed to explore its capabilities for prediction. This article presents an extension of the study performed in Knight y col., 2009. More specifically, in this study, a more detailed characterization of the roughness parameter and the number of roughness zones is explored producing additional scenarios. The performance of each scenario is evaluated by means of different fitting functions using rating curves for comparison. The research shows that the use of an adequate roughness description, such as a roughness factor calibrated for the whole cross section or a boulder roughness model calibrated for the channel bed plus roughness values from the CES roughness advisor for banks, leads to optimal model results in a mountain river.

El estudio tuvo como objetivo determinar el volumen de humedecimiento (bulbo húmedo) del hidrogel aplicado en tres tipos de suelo. Se utilizaron suelos: a) arcilloso (arcilla 52%; limo 32%; arena 16%); b) franco arcilloso limoso (arcilla 36%; limo 56%; arena 6%) c) franco arenoso (arcilla 12%; limo 32%; arena 56%), a los cuales se aplicó hidrogel al 1% de potasio. La aplicación se realizó con hidrogel previamente hidratado, en tres diámetros que fueron: 4.7, 7.0 y 10.5 cm con una longitud de 10 cm donde se obtuvieron los siguientes volúmenes iniciales 173.5, 384.8 y 866 cm3 que ocupaba el hidrogel. Se midió el volumen de humedecimiento (cm3), porcentaje de humedad y la hidratación del hidrogel en el suelo. Los resultados indican que el volumen de humedecimiento depende del volumen inicial, de manera que a mayor volumen inicial se tendrá mayor volumen de humedecimiento indiferente del tipo de suelo; sin embargo, el suelo franco arenoso presenta un mayor volumen de humedecimiento, seguramente por la movilidad del agua en el mismo. La zona humedecida incrementa su humedad en un 14% indiferentemente del tipo de suelo. La hidratación del hidrogel en el suelo solo alcanza un 42% en comparación con la hidratación en agua libre. La determinación del volumen de humedecimiento permite estimar la cantidad y ubicación de hidrogel que se debe aplicar en un cultivo en función del bulbo que se requiere formar en el suelo.// The objective of the study was to determine the wetting volume (wet bulb) of the hydrogel applied to three types of soil. Soils used were: a) clay (clay 52%; silt 32%; sand 16%); b) silty clay loam (36% clay; 56% silt; 6% sand) c) sandy loam (12% clay; 32% silt; 56% sand), to which 1% potassium hydrogel was applied. The application was made with previously hydrated hydrogel, in three diameters that were: 4.7, 7.0 and 10.5 cm with a length of 10 cm where the following initial volumes were obtained 173.5, 384.8 and 866 cm3 occupied by the hydrogel. The wetting volume (cm3), moisture percent, and the hydration of the hydrogel in the soil were measured. The results indicate that the humidification volume depends on the initial volume, so the higher the initial volume, the greater the humidification volume regardless of the type of soil; however, it presents a greater volume of humidification in the sandy loam soil, probably due to mobility of the water in it. The moistened area increases its humidity by 14% regardless of the type of soil. The hydration of the hydrogel in the soil only reaches 42% compared to hydrating it in free water. Determining the volume of wetting allows estimating the amount and location of hydrogel to be applied to a crop based on the bulb that needs to be formed in the soil.

The projections of replacement of cash for Automated Teller Machine (ATM) ATM for bank self-service provides to a banking network optimization and greater efficiency in all process of replacement of values in ATMs, as a result providing security, cost reduction, and balance in relation to seasonality. The aim of this work was to develop an Artificial Neural Network (ANN) to estimate the daily withdrawal values, also considering other variables that could influence the seasonality of these movements. The Artificial Neural Network, of the FeedForward Multilayer Perceptron (MLP) type, was trained based on ATM movement data from different location points. In the intermediate and output layers, activation functions of the relu-adam type were used. Thus, the performance of the developed ANN proved to be satisfactory, and it can be considered as a model for the implementation of effective use in the operation of cash replacement in ATMs of the bank networks or in shared ATMs

Alzheimer's disease is responsible for 60% of dementia in the world, affecting more than 35 million people, mostly the elderly population over 65 years old. The disease impairs not only memory, but also cognitive skills and emotional control of the patient. Those who contain the disease are not only ones to face this challenge; the family also suffers a lot of wear and tear with the problem. Thus, with the growth of portable and accessible devices, this work aims to present an application named Alzheimer Helper, which helps both an Alzheimer's patient and his family to deal with the disease, so that it is possible for the patient to develop his cognition, train their memory and avoid functional dependence.

Hospitals use germicidal lamps at ultraviolet wavelengths (UV-C -254 nm) to sterilize equipment, water and the environment in operating rooms. The food and medicine industries use them to disinfect various types of products, containers and packaging. Thistechnology is currently being used to disinfect environments, medical and hospital equipment and protective equipment in common use in the face of the current COVID-19 pandemic. In view of the UV-C applications to perform sterilization of environments andobjects, this project involves the development of a prototype using a hardware electronic prototyping platform of a chamber with portable UV lamps for disinfecting objectives. This prototype consists of a hardware module and a software module. In the hardware module, the necessary components for the assembly of the physical system were evaluated, as well as its basic functions, such as the activation of lamps and safety devices, while in the software module, the timing system, the activation and shutdown control were developed. of the lamps, the user interface and security, the exposure to radiation through a magnetic reed switch sensor to check the state of the door.

The present study aims to analyze the usability of DataScienceprograms for database analysis. Therefore, a database extracted from a public platform was used and applied in two programs, Python and Orange, in order to obtain a comparison between both. The bibliographic research served as a basis for the understanding of the programs and to base the obtained results. The Python program required work with the database, in file conversion as well as the need for programming language knowledge and learning. In the Orange program, the original database was used and its intuitive functionality allowed to obtain faster results, since their tools have names associated with what you want to get. With the obtained results it was possible to verify that the use of the Orange program proved to be more convenient for analysis of the manipulated database

Currently, the final destination of organic residues and aquatic macrophytes does not occur effectively, directly interfering with the environment and causing environmental problems. Therefore, the work aimed to reuse the organic waste from UNOESTE Campus 2, which comes from the university restaurant, urban cleaning and dairy cattle manure, as well as the aquatic macrophytes of the Cica dam in the municipality of President Prudent, using the vermicomposting technique in different treatments, analyzing the physical and chemical properties of the final compound and suggesting a better destination for such residues. Four treatments were carried out, with three repetitions each, namely: T1 (Dung, Organic waste), T2 (Aquatic Macrophyte, Dung, Organic waste), T3 (Urban cleaning waste, Dung, Organic waste) and T4 (Macrophyte, Waste urban cleaning, manure, organic waste).After collecting the compost, laboratory analyzes were carried out, which showed a significant increase in humidity when compared to the parametersof Normative Instruction SDA No. 25 of 2009. In the treatments carried out, T4 was highlighted by the breeding of earthworms. Therefore, through the execution of this work it was possible to confirm that the application of the vermicomposting technique is feasible for the treatment of organic waste.

In bioengineering there is a great motivation in studying the Hindmarsh-Rose (HR) neuron model due to the fact that it represents well the biological neuron, making it possible to simulate several behaviors of a real neuron, including periodic, aperiodic and chaotic behaviors, for example. Based on this model, this article proposes applying a linear optimal control design to the uncertain and chaotic behavior established by changes in the parameters of the system. To do so, the mathematical system of the RH model and its chaotic behavior are presented; afterwards, the fixed parametersare replaced by uncertain ones, and the chaotic dynamics of the system is investigated. At last, the linear optimal control is proposed as a method for controlling the chaotic behavior of the model, and numerical simulations are presented to show the efficiency of this proposal.

Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan menggunakan instrumen berupa angket kerja keras dan soal pilihan ganda materi fisika. Adapun, tujuan dari penelitian ini yaitu untuk mengetahui pengaruh karakter kerja keras terhadap hasil belajar siswa. Subjek penelitian ini adalah siswa kelas XII MIPA di SMA Negeri 1 Kota Jambi tahun ajaran 2020/2021. Penelitian ini menggunakan metode survey. Teknik analisis data pada penelitian ini menggunakan program SPSS dengan melakukan pengujian normalitas, korelasi, dan juga regresi linear sederhana. Dapat di lihat hasil signifikansi pada uji korelasi karakter kerja keras terhadap hasil belajar fisika didapatkan 0,000. Dari hasil tersebut dapat di lihat bahwa 0,000 < 0,05 yang artinya kedua variabel berkorelasi. Kemudian, ditinjau pada pearson correlation didapatkan hasil 0,927 yang berarti derajat hubungan atau nilai pearson correlation masuk pada kategori korelasi sangat kuat. Artinya, tingkat kerja keras siswa dalam mata pelajaran fisika sangat berhubungan dan berpengaruh pada hasil belajar siswa. Kemudian, dilakukan pula uji regresi linear sederhana dengan hasil analisis diperoleh persamaan regresi Y = -3,33 + 0,943 X . t hit = 15,235 dan p-value = 0,000 / 2 = 0,000

Slender structural systems susceptible to unstable buckling generally losestability at lower load levels than the linear buckling load of the perfect structure. This is mainly due to the geometric imperfections present in real structures. The objective of this work is to determine the integrity measures, together with the stability of the post-critical solutions of a mechanical system subject to unstable symmetrical buckling, Burtterfly-type bifurcation, using a discrete degree of freedom model. Uncertainties in the order of 10% will be considered in its deterministic parameters, to obtain lower and reliable limits for the project. The proposed uncertainty in the spring stiffness parameters does not change the type of bifurcation and the value of the critical load, only the value of the minimum post-critical of the bifurcation diagrams. The results showed the erosion of the attraction basin and the decrease of the factors of integrity, local and global, for the trivial solutions with the increase of the static load, for the investigated bifurcation.

Accurate forecast of aggregate end-users electric load profiles is becoming a hot topic in research for those main issues addressed in many fields such as the electricity services market. Hence, load forecast is an extremely important task which should be understood more in depth. In this research paper, the dependency of the day-ahead load forecast accuracy on the basis of the data typology employed in the training of LSTM has been inspected. A real case study of an Italian industrial load with samples recorded every 15 min for the year 2017 and 2018 was studied. The effect in the load forecast accuracy of different dataset cleaning approaches was investigated. In addition, the Generalised Extreme Studentized Deviate hypothesis testing was introduced to identify the outliers present in the dataset. The populations were constructed on the basis of an autocorrelation analysis that allowed for identifying a weekly correlation of the samples. The accuracy of the prediction obtained from different input dataset has been therefore investigated by calculating the most commonly used error metrics, showing the importance of data processing before employing them for load forecast.

Este estudo descreveu duas atividades do livro didático de inglês para negócios, nível elementar Business Result, Student’s Book (GRANT; HUGHES; REBECCA, 2012). Inicialmente, apresentou-se o perfil profissional do Secretariado Executivo (SE) no contexto atual e as habilidades necessárias para a sua formação profissional, destacando-se o uso da linguagem. Na sequência, tomaram-se como referência teórica as perspectivas sobre gêneros da linguagem e gramática do design visual (GDV). Teve-se como objetivo principal analisar duas atividades do referido livro, descrevendo-se ações e representações sociais, instituídas por meio de gêneros da linguagem, e seu vínculo com o cotidiano dos profissionais de SE. A metodologia foi de base interpretativista e descritiva, seguindo os padrões da pesquisa qualitativa. A análise mostrou que as atividades se reportam à área da comunicação, ações ecologicamente corretas, tecnologias avançadas e o uso de documentos administrativos e pessoais. A partir do estudo sobre a formação profissional dos assistentes administrativos, ou SE, gêneros da linguagem e GDV constatou-se que os temas e as imagens analisadas nas duas atividades fazem parte das rotinas administrativas das organizações em geral. Da mesma forma, o ensino de línguas para negócios procura reproduzir ações pedagógicas voltadas para esse contexto, podendo ser empregado para a formação profissional do SE. ABSTRACTThis study described two activities in the Business English textbook, elementary level, Business Result, Student's Book (GRANT; HUGHES;REBECCA, 2012). Initially, the Executive Secretariat (ES) professional profile was presented, as well as the skills for its professional training, highlighting the use of language. Then, the perspectives about language genres and visual design grammar (VDG) were approached. The main objective was to analyze two activities, describing social actions, and representations, instituted by means of language genres, and their connection to ES professionals. The methodology was interpretive and descriptive, following the qualitative patterns. The analysis showed that the activities refer to communication studies, ecolocally correct actions, advanced technologies and the use of administrative and personal documents. Based on the studies of future challenges for the executive and administrative assistants, or ES, language genders, and GDV, it was possible to conclude that the themes and images in the two activities are part of the administrative routines of organizations in general. Finally, the teaching of languages for business seeks to reproduce specific pedagogical actions for that context and can be applied for the ES professional training.

A fractal is a figure that has a unique characteristic that will be present in the entire domain of the figure. There are several different types of fractals, some of which are constructed from a simple figure such as a triangle ofplane geometry or a tetrahedron of spatial geometry. From the initial construction of a two-dimensional fractal starting with an equilateral triangle and using Napoleon's Theorem, in this article, we present a construction of a new three-dimensional fractal using ideas similar to Napoleon's Theorem in a tetrahedron. Using concepts of plane and spatial geometry, this fractal can be built from a regular tetrahedron, and from the midpoints of its edges a new tetrahedron with a 1/2 ratio side is built in relation to the initial tetrahedron. After this construction, the characteristics of the infinite application fractal are studied, such as the sum of the surface areas and the total volume of the formed figure.

Bugungi kunda ko’plab neft va gaz quduqlarini ta’mirlash ehtiyoji mavjud bo’lib, ta’mirlash ishlarini samarali hamda tezkor amalga oshirish muhim ahamiyatli hisoblanadi. Chunki neft va gazga bo’lgan talab kun sayin ortib bormoqda, ushbu talabni qondirish maqsadida neft va gaz quduqlarini to’xtovsiz ishlatish, ta’mirlashda zamonaviy texnologiyalardan foydalanish zarurdir. Shunday texnologiyalardan biri bu “Kaltyubing” texnologiyasi hisoblanadi.

Ушбу мақолада олий таълим йўналиш талбаларга фолклор адабиётинининг асосий мавзуларидан бири “Гўрўғли” достонлари ва уларнинг шаклланишига асос бўлган жиҳатлар, эпик анъана ва тарихий воқелик хусусида сўз юритилиб, эпоснинг мотив ва сюжет асослари қиёсий таҳлилга тортилади. Шу асосда мазкур достонлар вариант ёки алоҳида достон эканликлари ёритиб берилган.

In this article, graphic and methodical recommendations on the implementation of the project of the modern building of the center of entrepreneurs with the help of graphic programs are given.

Graphical abstract, Introduction The concentration of fluid and its analysis in human skin is innately a challenge due to its continuous movement and involvement in maximum life processes. The concentration of the fluid gets affected by the diffusion of fluids through the skin, which acts as the main barrier between the human body and the external environment. Therefore, it becomes imperative to study the process and impact of the diffusion of fluids through the skin. The problem becomes more interesting when the human body is immersed in water. Objectives The present paper studies the change in the fluid distribution of human skin during its immersion in water of different temperatures. The application part of the paper visualizes various impaired vascular function and muscle soreness by water immersion during the physiotherapy treatment. Methods A mathematical model based on the two-dimensional diffusion equation, along with appropriate boundary conditions, has been formulated. The maximum of the relevant parameters, such as fluid regulation, transfer coefficient, evaporation rate, etc., influencing the fluid distribution, have been incorporated. The model has been solved by variational finite element method, and numerical results have been obtained by the Crank-Nicholson scheme. Results The increase in fluid concentration due to treatment with cold and acute hot water immersion has been noted, and the role of water immersion in enhancing the recovery in exercise-induced muscular damage has been analyzed. Conclusions The paper addressed the issue of rate of water diffusion through human skin, which otherwise couldn't be drawn from the analogy of gas diffusion through the membrane due to the variation in permeabilities of the two processes. The paper has applications in water immersion therapies and other activities like monitoring swimming induced pulmonary edema, etc.

Graphical abstract, miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

The article discusses the issues of improving the performance of electrical systems of cars based on adaptive converters of electrical energy. The economic development of Uzbekistan depends on the level of development of the machine-building industry, its competitiveness in the world market in terms of technical, technological, operational and economic indicators as a machine. In a market economy, the rapid modernization of production based on new modern equipment, the widespread introduction of the most advanced technological processes and fast adaptive production are of great importance.

Newborns with severe congenital malformations need radical surgical correction as soon as possible for ensure the quality of life of the infant in the future. Pathological changes associated with the underlying pathology may be accompanied to severe disturbances of homeostasis in the postoperative period. The aim of the study. To assess the level of ionic composition of plasma in infants with congenital malformations during surgical correction and various types of combined anesthesia. Investigated problem: To prevent electrolyte peri- and postoperative complications, it is obligatory to perform preoperative preparation and stabilization of laboratory parameters, for a child with congenital malformations and to monitor they throughout the operation. The main scientific results: The electrolyte composition in the examined groups of infants did not show significant differences from age norms. The concentration of potassium was the lowest in group III of the examined in comparison with groups I and II at the stage of preparation for surgery (p=0.0041; p=0.0102), induction of anesthesia (p=0.0053; p=0.0054), while children of groups I and II were diagnosed with a tendency to the upper limit of normal serum potassium levels during all observation periods. Elevated sodium levels were diagnosed in group III at all stages of surgical treatment and in group II of infants with congenital malformations at the stage of the most painful and traumatic moment of surgery (159.94±4.89 – II, 139.27±3.043 – III, p=0.1857). The area of practical use of the research results: pediatric anesthesiology Innovative technological product: laboratory control Scope of the innovative technological product: neonatal intensive care unit, surgery

Ушбу мақоланинг мазмуни, моҳияти шундан иборатки, бугуни кун масалалари кўпроқ катта сонлар усида бажарилмоқда. Ушбу катта сонлар устида амаллар бажарилганда айрим ноқулайликларга дуч келамиз. Келтирилган айрим ноқулайликларни бартараф этишга қаратилган.

Статья посвящена проблеме языкового означивания эмоций в поэтической речи И.А. Бунина. Слово, объективируя в языке результаты когнитивноаффективной деятельности автора, выступает выразителем «живого» знания и «значащих переживаний» субъекта речи, что обеспечивает доступ к информационной, смысловой и эмоционально-образной базе художника слова.

In this article, the author tries to analyze the problems of generational change and gives information on how these problems are solved during the period of independence. It tells about the creation of branches of the Youth Union of Uzbekistan in the Republic of Karakalpakstan, regions and the city of Tashkent to increase the effectiveness of state youth policy, to further increase the effectiveness of the support system, to create the necessary conditions for their full and active participation in the socio-political life of the country, ensuring peace and tranquility in society and in the family, as well as educating the younger generation in the spirit of respect for centuries-old traditions.

Ушбу мақолада электр энергияси ва электр ускуналаридан оқилона фойдаланиш самарадорлигини ошириш зарурати тўғрисидаги муаммо ёритилган. Шу билан биргаликда электр станцияларининг ўрнатилган қувватлар таркиби, электр станцияларида ёқилғи истеъмолининг таркиби, иқтисодиёт соҳалари ва аҳоли бўйича электр энергияси истеъмолининг таркиби тўғрисидаги маълумотлар ҳамда эксплуатация самарадорлигини ошири борасида эътиборни қаралиш керак бўлган ишдан чиқиш сабаблари келтирилган.

The article examines the appearance of the term "women's prose" in modern Russian literature.