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Objetivo: A escala Richimond de Agitação-Sedação (RASS) auxilia na assistência, diminuindo a dosagem e o tempo da sedação e consequentemente, o tempo de ventilação mecânica. OBJETIVOS: associar o perfil, nível de sedação e os critérios de sua interrupção com mortalidade em pacientes sob ventilação mecânica. Métodos: Estudo prospectivo, longitudinal e quantitativo, com 204 pacientes, por meio da Escala RASS e Sepse Related Organ Failure Assessment (SOFA), A análise estatística foi por teste de Tukey, Pearson e Qui quadrado. Resultados: Da amostra, 61,3% era do sexo masculino, 38,7% do feminino, idade média 56,1 anos, tempo de permanência na UTI 10,7 dias. RASS médio -2,4 e SOFA 15,8, considerado de alto risco. Nos pacientes sedados de um a cinco dias, a droga mais utilizada foi o fentanil em 50,9%. Aqueles com RASS de -3 à -5 receberam alta hospitalar 48,8% e 51,1% morreram. Quanto aos pacientes que foram desligados diariamente a sedação, 40,3% receberam alta. Os que apresentavam SOFA médio de 3,1, e 59,7% morreram, com média SOFA de 8,1 (p=0,035). Dos que não tiveram a sedação interrompida diariamente, 43,9% receberam alta da UTI, com média SOFA de 2,8 e morreram 56,1% pacientes, com média SOFA de 9,6 (p<0,001). Conclusão: A avaliação do nível da sedação e interrupção diária auxilia na assistência em UTI, favorece a adequação ao tratamento e melhor recuperação do paciente, porém, não se configurou como fator independente para previsão de mortalidade. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Medicina e Saúde de Brasília is the property of Revista de Medicina e Saude de Brasilia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objetivo: A Unidade de terapia intensiva pode gerar um ambiente altamente estressor onde os pacientes vivenciam experiências de desconforto físico e psicológico como, por exemplo, a dor, que quando não tratada pode contribuir para um desfecho desfavorável e aumento da mortalidade. O objetivo deste estudo é Identificar o perfil sociodemográfico/clínico de pacientes em UTI, associar presença de dor com a utilização de analgo-sedação com mortalidade; verificar eficiência do Sequencial Organ Failure Assessment e identificar a vigência de dor como indicador prognóstico. Métodos: Estudo transversal com amostra de 240 pacientes. A coleta de dados foi realizada através da Escala de sedação e agitação de Richmond (RASS), Escala de dor visual e numérica (EVN) e Behavioral Pain Scale (BPS). Os dados clínicos foram obtidos de prontuário eletrônico e os dados posteriormente foram submetidos à análise de Variância, teste de comparação múltipla de médias de Tukey e Quiquadrado. Resultados: Prevaleceram pacientes não idosos, masculinos, neurológicos, cirúrgicos, com sedação profunda. Houve maior mortalidade em pacientes com sedação profunda, dor intensa, cirúrgicos e idosos e maior tempo de internação naqueles com sedação moderada. A analgo-sedação não suprimiu a dor, mas a controlou sua intensidade. O Fentanil foi a droga mais utilizada. O SOFA não atuou como bom índice prognóstico, já a dor intensa mostrou-se como boa preditora de mortalidade. Conclusão: Conclui-se que a identificação da dor por meio de escalas auxilia nas tomadas de decisão e no manejo da analgo-sedação em unidade de terapia intensiva. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Medicina e Saúde de Brasília is the property of Revista de Medicina e Saude de Brasilia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de Medicina e Saúde de Brasília is the property of Revista de Medicina e Saude de Brasilia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of the study was to identify the civil servants' perceptions about organizational values in public institutions of indirect federal administration and to observe variations in conformity to hierarchical position and type of entity. Four institutions were focused, using a sample of 128 civil servants, to whom the Organizational Values Inventory (TAMAYO; MENDES; PAZ, 2000) and a socio- -demographic form were applied. The results showed that there is agreement between managers and subordinates about the set values that constitute the priorities of the institutions analyzed, but the managers consider more relevant the values of autonomy and the subordinates the values of hierarchy. Regarding the value priorities in each entity, the civil servants' perceptions indicated some elements of differentiation, so that the autarchy and the public foundation emphasized the values of autonomy and the public company and the mixed capital company emphasized the values of mastery. The similarity in values structures, however, prevailed among the institutions, since they attributed greater relevance to the values of hierarchy and conservatism. It shows that these institutions, despite the efforts implemented since the reform in the 1990s, are still characterized by values related to conservation of its structure, customs, norms and traditions. Furthermore, they focus on the authority, obedience and social power. The implications, limitations and contributions of the study are discussed, with suggestions for future research. [ABSTRACT FROM AUTHOR]

Contamination of enteral diets represents a high risk of compromising the patient's medical condition. To assess the microbiological quality and aseptic conditions in the preparation and administration of handmade and industrialized enteral diets offered in a hospital in the Valley of Jequitinhonha, MG, Brazil, we performed a microbiological analysis of 50 samples of diets and 27 samples of surfaces, utensils, and water used in the preparation of the diets. In addition, we assessed the good handling practices of enteral diets according to the requirements specified by the Brazilian legislation. Both kinds of enteral diets showed contamination by coliforms and Pseudomonas spp. No sample was positive for Staphylococcus aureus and Salmonella spp. On the other hand, Listeria spp. was detected in only one sample of handmade diets. Contamination was significantly higher in the handmade preparations (p < 0.05). Nonconformities were detected with respect to good handling practices, which may compromise the diet safety. The results indicate that the sanitary quality of the enteral diets is unsatisfactory, especially handmade diets. Contamination by Pseudomonas spp. is significant because it is often involved in infection episodes. With regard to aseptic practices, it was observed the need of implementing new procedures for handling enteral diets.

Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively. Their schistosomicidal, trypanocidal, and leishmanicidal activities were evaluated in vitro against Schistosoma mansoni adult worms, trypomastigote and amastigotes forms of Trypanosoma cruzi, and promastigote forms of Leishmania amazonensis. Compound 1 did not display significant schistosomicidal activity, but it presented potent trypanocidal activity, since it induced death of trypomastigotes and amastigotes with IC50/24h of 9.3μM and 7.3μM, respectively. Compound 2 had slight trypanocidal and schistosomicidal activities. None of the compounds were active against L. amazonensis. These results demonstrated that furofuran lignans are potentially useful for anti-parasitic drugs development and should be further investigated., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

The objective of the study was to validate the content of the dimensions that constituted nonadherence to treatment of arterial systemic hypertension. It was a methodological study of content validation. Initially an integrative review was conducted that demonstrated four dimensions of nonadherence: person, disease/treatment, health service, and environment. Definitions of these dimensions were evaluated by 17 professionals, who were specialists in the area, including: nurses, pharmacists and physicians. The Content Validity Index was calculated for each dimension (IVCi) and the set of the dimensions (IVCt), and the binomial test was conducted. The results permitted the validation of the dimensions with an IVCt of 0.88, demonstrating reasonable systematic comprehension of the phenomena of nonadherence.

This paper assesses the quality of assistance in a clinical trial outpatient center as well as the patients understanding of the informed consent (IC); determine the reasons why they participate and detail socio-economic levels. A cross-sectional study was adopted in a clinical trial outpatient center using a self-explanatory questionnaire. All 100 respondents considered the assistance at the center excellent (86%) or good (9%). Almost all of them were well informed about the content of the IC. Their knowledge about the right to "confidentiality", present in all ICs, was 6 times higher than their knowledge about their right to "access the results", generally not included in the IC. The main reasons for participating were "to know more about ones health" (59%) and to "to benefit other people in the future" (47%). The participants income varied from 3 to 5 minimum wages (48%) and most (66%) concluded at least the 4th grade of basic education in Brazil. The subjects showed the economical characteristics of the average population of Rio de Janeiro. Their level of education allowed them to sign and to understand what they were signing. They were aware of the existence of the IC and its content. The main reason for participating was for one s own benefit and for the benefit of others.