Search

Your search keyword '"Zhu Dalong"' showing total 831 results
Start Over Author "Zhu Dalong"
831 results on '"Zhu Dalong"'

209. Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice

Author

Wang, Weimin, primary, Zhang, Dongming, additional, Yang, Rongze, additional, Xia, Wei, additional, Qian, Kun, additional, Shi, Zhengrong, additional, Brown, Robert, additional, Zhou, Huifen, additional, Xi, Yue, additional, Shi, Lin, additional, Chen, Ling, additional, Xu, Feng, additional, Sun, Xiaojian, additional, Zhu, Dalong, additional, and Gong, Da-Wei, additional

Published
2018
Full Text
View/download PDF

211. Comparative effectiveness of metformin monotherapy in extended release and immediate release formulations for the treatment of type 2 diabetes in treatment-naïve Chinese patients: Analysis of results from the CONSENT trial

Author

Ji, Linong, primary, Liu, Jing, additional, Yang, Jing, additional, Li, Yufeng, additional, Liang, Li, additional, Zhu, Dalong, additional, Li, Quanmin, additional, Ma, Tianrong, additional, Xu, Haiyan, additional, Yang, Yanlan, additional, Zeng, Jiaoe, additional, Feng, Bo, additional, Qu, Shen, additional, Li, Yiming, additional, Ma, Lizhen, additional, Lin, Shanshan, additional, Wang, Jianping, additional, Li, Wei, additional, Song, Weihong, additional, Li, Xiaoxing, additional, Luo, Yong, additional, Xi, Shugang, additional, Lin, Mei, additional, Liu, Yu, additional, and Liang, Zerong, additional

Published
2018
Full Text
View/download PDF

216. Efficacy and safety of lixisenatide in a predominantly A sian population with type 2 diabetes insufficiently controlled with basal insulin: T he GetGoal‐L‐C randomized trial

Author

Yang, Wenying, primary, Min, Kyungwan, additional, Zhou, Zhiguang, additional, Li, Ling, additional, Xu, XiangJin, additional, Zhu, Dalong, additional, Venkateshwar Rao, A., additional, Murthy, Laxminarayanappa Sreenivasa, additional, Zhang, Nianxian, additional, Li, Ivy, additional, Niemoeller, Elisabeth, additional, and Shang, Shuhua, additional

Published
2017
Full Text
View/download PDF

223. The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

Author

Zou, Xiantong, primary, Zhou, Xianghai, additional, Ji, Linong, additional, Yang, Wenying, additional, Lu, Juming, additional, Weng, Jianping, additional, Jia, Weiping, additional, Shan, Zhongyan, additional, Liu, Jie, additional, Tian, Haoming, additional, Ji, Qiuhe, additional, Zhu, Dalong, additional, Ge, Jiapu, additional, Lin, Lixiang, additional, Chen, Li, additional, Guo, Xiaohui, additional, Zhao, Zhigang, additional, Li, Qiang, additional, and Zhou, Zhiguang, additional

Published
2017
Full Text
View/download PDF

232. Pregnancy outcomes in patients with type 1 diabetes in China: a retrospective study

Author

Zheng, Xueying, primary, Yan, Jinhua, additional, Yang, Daizhi, additional, Luo, Sihui, additional, Zhu, Dalong, additional, Ran, Xingwu, additional, Zhao, Jiajun, additional, Xiao, Xinhua, additional, Guo, Xiaohui, additional, Yang, Tao, additional, Huang, Qin, additional, Zhou, Zhiguang, additional, Liu, Fang, additional, Hu, Ji, additional, Lu, Jing, additional, Ma, Jing, additional, Zhou, Xinli, additional, Ping, Fan, additional, Gu, Nan, additional, Zhang, Mei, additional, Li, Wenwen, additional, Yang, Yaling, additional, Fang, Chen, additional, Yang, Huixia, additional, and Weng, Jianping, additional

Published
2016
Full Text
View/download PDF

233. Multiple organ-specific autoantibodies in patients with phenotypic type 2 diabetes in China: a post-hoc analysis of the China National Diabetes and Metabolic Disorders Study

Author

Xiang, Yufei, primary, Huang, Gan, additional, Ji, Linong, additional, Jia, Weiping, additional, Weng, Jianping, additional, Lu, Juming, additional, Zhu, Yaxi, additional, Feng, Qiong, additional, Li, Xia, additional, Yang, Tubao, additional, Liu, Zhenqi, additional, Shan, Zhongyan, additional, Liu, Jie, additional, Tian, Haoming, additional, Ji, Qiuhe, additional, Zhu, Dalong, additional, Ge, Jiapu, additional, Lin, Lixiang, additional, Chen, Li, additional, Guo, Xiaohui, additional, Zhao, Zhigang, additional, Li, Qiang, additional, Zuo, Xuan, additional, Liu, Xinyuan, additional, Yang, Wenying, additional, and Zhou, Zhiguang, additional

Published
2016
Full Text
View/download PDF

237. Surface Patterning of PEDOT:PSS by Photolithography for Organic Electronic Devices

Author

Ouyang, Shihong, Xie, Yingtao, Wang, Dongping, Zhu, Dalong, Xu, Xin, Tan, Te, and Fong, Hon Hang

Subjects
Article Subject
Abstract

Along with the development of organic electronics, conductive polymer of PEDOT:PSS has been attracting more and more attention because they possess various novel electrical, optical, and mechanical properties, which render them useful in modern organic optoelectronic devices. Due to its organic nature, it is lightweight and can be fabricated into flexible devices. For better device processing and integrating, it is essential to tune their surface morphologies, and photolithography is the best choice at present. In this paper, current PEDOT:PSS patterning approaches using photolithography are reviewed, and some of our works are also briefly introduced. Appropriate photolithographic patterning process for PEDOT:PSS will enable its application in future organic electronics.

Published
2015
Full Text
View/download PDF

238. Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies.

Author

Zhou Zhang, Bing Zhang, Xin Wang, Xin Zhang, Yang, Qing X., Zhao Qing, Wen Zhang, Dalong Zhu, Yan Bi, Zhang, Zhou, Zhang, Bing, Wang, Xin, Zhang, Xin, Qing, Zhao, Zhang, Wen, Zhu, Dalong, and Bi, Yan

Subjects
SMELL, TYPE 2 diabetes, GLUCAGON-like peptide 1, MONTREAL Cognitive Assessment, GLYCEMIC control, OBESITY
Abstract

Objective: Large numbers of people with type 2 diabetes are obese. However, changes in cognition and related brain function in obese people with diabetes have not been characterized. Here, we investigated cognition, olfactory function, and odor-induced brain alterations in these patients and therapeutic effects of glucagon-like peptide 1 receptor agonists (GLP-1Ras) on their psychological behavior and olfactory networks.Research Design and Methods: Cognitive, olfactory, and odor-induced brain activation assessments were administered to 35 obese and 35 nonobese people with type 2 diabetes and 35 control subjects matched for age, sex, and education. Among them, 20 obese individuals with diabetes with inadequate glycemic control and metformin monotherapy received GLP-1Ra treatment for 3 months and were reassessed for metabolic, cognitive, olfactory, and neuroimaging changes.Results: Obese subjects with diabetes demonstrated lower general cognition and olfactory threshold scores, decreased left hippocampal activation, and disrupted seed-based functional connectivity with right insula compared with nonobese subjects with diabetes. Negative associations were found between adiposity and episodic memory and between fasting insulin and processing speed test time in diabetes. Mediation analyses showed that olfactory function and left hippocampus activation mediated these correlations. With 3-month GLP-1Ra treatment, obese subjects with diabetes exhibited improved Montreal Cognitive Assessment (MoCA) score, olfactory test total score, and enhanced odor-induced right parahippocampus activation.Conclusions: Obese subjects with type 2 diabetes showed impaired cognition and dysfunctional olfaction and brain networks, the latter of which mediated adiposity in cognitive impairment of diabetes. GLP-1Ras ameliorated cognitive and olfactory abnormalities in obese subjects with diabetes, providing new perspectives for early diagnosis and therapeutic approaches for cognitive decrements in these patients. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

240. Identification of autoimmune type 1 diabetes and multiple organ‐specific autoantibodies in adult‐onset non‐insulin‐requiring diabetes in China: A population‐based multicentre nationwide survey.

Author

Xiang, Yufei, Huang, Gan, Zhu, Yaxi, Zuo, Xuan, Liu, Xinyuan, Feng, Qiong, Li, Xia, Yang, Tubao, Lu, Juming, Shan, Zhongyan, Liu, Jie, Tian, Haoming, Ji, Qiuhe, Zhu, Dalong, Ge, Jiapu, Lin, Lixiang, Chen, Li, Guo, Xiaohui, Zhao, Zhigang, and Li, Qiang

Subjects
TYPE 1 diabetes, AUTOANTIBODIES, AUTOIMMUNE diseases, DIABETES, TYPE 2 diabetes, GLUTAMIC acid
Abstract

Aims: To investigate the prevalence of adult‐onset autoimmune diabetes (ADM) and predisposition to autoimmune diseases by quantifying serum organ‐specific autoantibodies in people with phenotype of type 2 diabetes (T2D). Materials and methods: We included a nationally representative sample of 46 239 adults aged ≥20 years from 14 provinces, of whom 4671 had diabetes, plus 1000 control subjects with normal glucose tolerance (NGT). Participants were screened centrally for autoantibodies to glutamic acid decarboxylase (GAD), islet antigen 2 (IA2) and zinc transporter isoform‐8 (Znt8) and were defined as having ADM where positive for these antibodies. We then assayed thyroid peroxidase (TPO), tissue transglutaminase (tTG) and 21‐hydroxylase (21‐OH) autoantibodies in randomly selected participants with ADM and in age‐matched, sex‐matched and non‐ADM controls with T2D plus controls with NGT. Results: Post‐normalization, the standardized prevalence rate of ADM was 6.0% (95% confidence interval [CI] 5.3‐6.8) in initially non‐insulin‐requiring participants with ADM, corresponding to six million adults in China, in whom adjusted antibody positivity was: TPO autoantibodies 16.3% (95% CI 10.8‐21.8), tTG autoantibodies 2.1% (95% CI 0.0‐4.2), and 21‐OH autoantibodies 1.8% (95% CI ‐0.2 to 3.8). Those participants with ADM who were GAD autoantibody‐positive had high risk of TPO autoantibody positivity (odds ratio [OR] 2.39, P = 0.0031) and tTG autoantibody positivity (OR 6.98, P = 0.027), while those positive for IA2 autoantibodies had a high risk of tTG autoantibody positivity (OR 19.05, P = 0.001). Conclusions: A proportion of people with phenotype of T2D in China have ADM, with diabetes‐associated autoantibodies, and may be at risk of developing other organ‐specific autoimmune diseases; therefore, it may be clinically relevant to consider screening such Chinese populations. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

241. Direct medical costs for patients with type 2 diabetes in 16 tertiary hospitals in urban China: A multicenter prospective cohort study.

Author

Li, Xiang, Xu, Zhangrong, Ji, Linong, Guo, Lixin, Liu, Jing, Feng, Kun, Xu, Yushan, Zhu, Dalong, Jia, Weiping, Ran, XinWu, Chen, Limin, Zhao, Shi, Shi, Bingying, Zhu, Jun, Shan, Zhongyan, Zhou, Zhiguang, Zeng, Longyi, Weng, Jianping, Ren, Qian, and Zhou, Yan

Subjects
MEDICAL care costs, GLUCAGON-like peptide-1 receptor, TYPE 2 diabetes, GLUCAGON-like peptide-1 agonists, DIRECT costing, HEALTH care reform
Abstract

Aims/Introduction: To investigate the direct medical costs for patients with type 2 diabetes in China and to examine the influencing factors. Materials and Methods: In the present multicenter study, 1,070 patients with type 2 diabetes from 16 tertiary hospitals in 14 major cities of China were enrolled. Patient data and direct medical costs were collected during a follow‐up period of 6 months at intervals of 1 month. The log‐transformed direct medical costs were fitted by a generalized estimation equation to indicator variables for demographics, metabolic control, treatments, complications and comorbidities. Results: Data of 871 participants were included in the analysis. The mean annual total direct medical costs and outpatient medical costs were $1,990.20 and $1,687.20 respectively. The average costs per inpatient per admission were $2,127.10. The share of out‐of‐pocket for total medical costs, outpatient costs and cost per inpatient per admission were 45.4, 46.3 and 26.0% respectively. Independent determinants of total medical costs were diabetes duration, dyslipidemia and diabetic complications, such as neuropathy and nephropathy, as well as diabetes treatment, such as the use of glucagon‐like peptide‐1 receptor agonists. Costs showed prominent variation across centers. Conclusions: Diabetes is imposing a growing economic burden in patients with type 2 diabetes in China. Diabetes‐related complications and comorbidities have a great impact on the medical costs. As different health policies, economic development and regional health inequalities also have an important influence on the direct medical cost, healthcare reform needs to optimize resource allocation in health service delivery systems, and provide more equitable and affordable healthcare. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

242. Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high‐fat diet‐fed mice.

Author

Jing, Yali, Sun, Qingmin, Xiong, Xiaolu, Meng, Ran, Tang, Sunyinyan, Cao, Shu, Bi, Yan, and Zhu, Dalong

Subjects
HEPATOCYTE growth factor, TYPE 2 diabetes, FARNESOID X receptor, INSULIN resistance, LIPID metabolism
Abstract

Aims/Introduction: Type 2 diabetes mellitus is frequently accompanied by fatty liver disease. Lipid accumulation within the liver is considered as one of the risk factors for insulin resistance. Hepatocyte growth factor (HGF) is used to treat liver dysfunction; however, the effect and mechanism of HGF on hepatic lipid metabolism are still not fully understood. Materials and Methods: Male C57BL/6 mice were induced with a high‐fat diet for 12 weeks, followed by a 4‐week treatment of HGF or vehicle saline. The levels of fasting blood glucose, fasting insulin and homeostatic model assessment of insulin resistance were calculated for insulin sensitivity. Biochemical plasma parameters were also measured to assess the effect of HGF on lipid accumulation. Additionally, genes in the lipid metabolism pathway were evaluated in palmitic acid‐treated HepG2 cells and high‐fat diet mice. Results: HGF treatment significantly decreased the levels of fasting blood glucose, hepatic triglyceride and cholesterol contents. Additionally, HGF‐regulated expression levels of sterol regulatory element‐binding protein‐1c/fatty acid synthase, peroxidase proliferator‐activated receptor‐α, and upstream nuclear receptors, such as farnesoid X receptor and small heterodimer partner. Furthermore, c‐Met inhibitor could partially reverse the effects of HGF. Conclusions: HGF treatment can ameliorate hepatic insulin resistance and steatosis through regulation of lipid metabolism. These effects might occur through farnesoid X receptor–small heterodimer partner axis‐dependent transcriptional activity. HGF reduced the levels of fasting blood glucose, blood lipid level, and improved the HFD‐fed mice. HGF significantly regulated lipogenesis‐related genes SREBP‐1c/FAS as well as PPARα, and nuclear receptors such as FXR, SHP. HGF ameliorates hyperglycemia and by improving hepatic insulin resistance and steatosis in HFD‐fed C57BL/6 mice. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

245. The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

Author

Liu, Jin, primary, Bian, Lingling, additional, Ji, Li, additional, Chen, Yang, additional, Chen, Heng, additional, Gu, Yong, additional, Ma, Bingqin, additional, Gu, Wei, additional, Xu, Xinyu, additional, Shi, Yun, additional, Wang, Jian, additional, Zhu, Dalong, additional, Sun, Zilin, additional, Ma, Jianhua, additional, Jin, Hui, additional, Shi, Xing, additional, Miao, Heng, additional, Xin, Bing, additional, Zhu, Yan, additional, Zhang, Zhenwen, additional, Bu, Ruifang, additional, Xu, Lan, additional, Shi, Guangde, additional, Tang, Wei, additional, Li, Wei, additional, Zhou, Dongmei, additional, Liang, Jun, additional, Cheng, Xingbo, additional, Shi, Bimin, additional, Dong, Jixiang, additional, Hu, Ji, additional, Fang, Chen, additional, Zhong, Shao, additional, Yu, Weinan, additional, Lu, Weiping, additional, Wu, Chenguang, additional, Qian, Li, additional, Yu, Jiancheng, additional, Gao, Jialin, additional, Fei, Xiaoqiang, additional, Zhang, Qingqing, additional, Wang, Xueqin, additional, Cui, Shiwei, additional, Cheng, Jinluo, additional, Xu, Ning, additional, Wang, Guofeng, additional, Han, Guoqing, additional, Xu, Chunrong, additional, Xie, Yun, additional, An, Minmin, additional, Zhang, Wei, additional, Wang, Zhixiao, additional, Cai, Yun, additional, Fu, Qi, additional, Fu, Yu, additional, Zheng, Shuai, additional, Yang, Fan, additional, Hu, Qingfang, additional, Dai, Hao, additional, Jin, Yu, additional, Zhang, Zheng, additional, Xu, Kuanfeng, additional, Li, Yifan, additional, Shen, Jie, additional, Zhou, Hongwen, additional, He, Wei, additional, Zheng, Xuqin, additional, Han, Xiao, additional, Yu, Liping, additional, She, Jinxiong, additional, Zhang, Mei, additional, and Yang, Tao, additional

Published
2016
Full Text
View/download PDF

250. Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes.

Author

Zhou Zhang, Bing Zhang, Xin Wang, Xin Zhang, Qing X. Yang, Zhao Qing, Jiaming Lu, Yan Bi, Dalong Zhu, Zhang, Zhou, Zhang, Bing, Wang, Xin, Zhang, Xin, Yang, Qing X, Qing, Zhao, Lu, Jiaming, Bi, Yan, and Zhu, Dalong

Subjects
PEOPLE with diabetes, COGNITION disorders, ODORS, NEURAL circuitry, OLFACTORY perception, MAGNETIC resonance imaging, PSYCHOLOGY, TYPE 2 diabetes & psychology, BRAIN, COMPARATIVE studies, NEUROPSYCHOLOGICAL tests, RESEARCH methodology, MEDICAL cooperation, NEUROLOGIC examination, TYPE 2 diabetes, SENSORY perception, REGRESSION analysis, RESEARCH, EVALUATION research, CASE-control method, NEURAL pathways, EXECUTIVE function
Abstract

Type 2 diabetes is reported to be associated with olfactory dysfunction and cognitive decline. However, whether and how olfactory neural circuit abnormalities involve cognitive impairment in diabetes remains uncovered. This study thus aimed to investigate olfactory network alterations and the associations of odor-induced brain activity with cognitive and metabolic parameters in type 2 diabetes. Participants with normal cognition, including 51 patients with type 2 diabetes and 41 control subjects without diabetes, underwent detailed cognitive assessment, olfactory behavior tests, and odor-induced functional MRI measurements. Olfactory brain regions showing significantly different activation between the two groups were selected for functional connectivity analysis. Compared with the control subjects, patients with diabetes demonstrated significantly lower olfactory threshold score, decreased brain activation, and disrupted functional connectivity in the olfactory network. Positive associations of the disrupted functional connectivity with decreased neuropsychology test scores and reduced pancreatic function were observed in patients with diabetes. Notably, the association between pancreatic function and executive function was mediated by olfactory behavior and olfactory functional connectivity. Our results suggested the alteration of olfactory network is present before clinically measurable cognitive decrements in type 2 diabetes, bridging the gap between the central olfactory system and cognitive decline in diabetes. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results