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Recommended technologies for the tourism system, such as the travelocity.com and visiteurope.com, have gained tremendous popularity in the past few years. Although many research works have been dedicated to improving recommendation services and overcoming recommendation challenges, little attention has been attached to the application of recommended technology in Rural Tourism. In order to solve the difficult ‘what to choose’ problem caused by information overload, this paper combines the features of Rural Tourism, giving a first attempt in this field. First, an effective method of seasonal feature extraction is proposed. Next, a detailed method of geographical distribution feature extraction is described. In particular, a block-number basing on the geographical distribution feature to the Attractions is proposed. Furthermore, the FM-based (Factorization Machines) algorithm is presented as a recommended solution for Rural Tourism. Finally, the comparative experiments are provided to prove the effectiveness of this solution.

Background: The ratios of systemic inflammatory cells, neutrophil lymphocyte (NLR), platelet lymphocyte (PLR) and lymphocyte monocyte (LMR) can be used as prognostic indicators of breast cancer (BC). The purpose of this study was to explore the value of inflammatory markers in predicting the pathological reaction and prognosis of patients with BC after surgical treatment. Methods: A total of 144 BC patients who received standard neoadjuvant therapy in Shangqiu First People’s Hospital from January 2016 to January 2018 were analyzed retrospectively. The clinical data of patients were collected and the effects of NLR, PLR and LMR on disease-free survival were evaluated by chi-square test and COX regression. The diagnostic value of NLR, PLR and LMR in BC recurrence was analyzed by receiver operating characteristic (ROC) curve. Results: Of the 144 patients, 20 (13.89%) had local or distant metastasis. The areas under the ROC curve of NLR, PLR and LMR in peripheral blood for the diagnosis of BC recurrence were 0.713, 0.683 and 0.765, respectively. Multivariate Cox regression analysis showed that T stage, lymph node metastasis, PLR, LMR and HER2 were independent risk factors for prognosis. Conclusion: Inflammatory markers based on NLR, PLR and LMR may become biological indicators to predict the pathological features and prognosis of invasive BC in the future.

In power Internet of Things environment, the existing border-based protection system and the “one-time authentication, one-time authorization, and long-term effective” approach are difficult to deal with the threat of attacks from internal and external devices and users with legal authority. In order to solve the problem of authorized access of power equipment and users, combined with behavior risk assessment, a continuous trust evaluation scheme of power equipment and users is presented in this paper. The scheme is evaluated by the combination of direct trust, indirect trust, and comprehensive trust and adds the penalty reward factor and time attenuation function to improve the reliability of the results. In addition, this paper will quantify the risk of the behavior of power equipment and users and regard it as a factor affecting the degree of trust, so as to achieve continuous trust evaluation of equipment and users.

Sugar alcohols are the prominent alternatives of sugars in food, medical, and health industries. The ruthenium supported on multiwalled carbon nanotubes (Ru/MWCNTs) catalysts were prepared based on the Ru valence regulation strategy and applied for selective sugar hydrogenation to prepare various sugar alcohols including xylitol, arabinitol, sorbitol, mannitol, and galactitol for the first time, with high selectivity (>99.0%) and yield (>98.0%) under mild conditions (≤110 °C, 3.0 MPa H2 pressure). The hydrogenation reaction of xylose was further optimized and under mild conditions (100 °C, 3.0 MPa H2 pressure, and 500 rpm), which were lower than ever reported for high efficient synthesis of xylitol, 99.8% xylose conversion and 99.0% xylitol yield were achieved after 120 min of reaction.

Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied two algorithms to uncover the immune infiltration landscape of the immune microenvironment in 491 HCC patients. Three immune infiltration patterns were defined using the CIBERSORT method, and the immune cell infiltration (ICI) scores were established using principal component analysis. In the high ICI score group, the activation of the Wnt/β-catenin pathway was significantly enriched and expressions of immune checkpoint genes increased, which showed a pessimistic outcome. The low ICI score group was characterized by increased TMB and enrichment of metabolism-related pathways. Further analysis found that the ICI score exhibited a significant difference in age ≥65/age

Background: Pegylated recombinant human granulocyte colony-stimulating factors (PEG-rhG-CSFs) are more commonly and widely used than recombinant human granulocyte colony-stimulating factors (rhG-CSFs) in preventing chemotherapy-induced neutropenia in patients with stage II-IV breast cancer. To reduce the financial burden on these patients, the corresponding medical insurance directory needs to be revised.Objectives: To evaluate the cost-effectiveness of PEG-rhG-CSF versus rhG-CSF in patients with stage II-IV breast cancer in central China.Methods: Two Markov models, a chemotherapy model and a post-chemotherapy model, were developed to study the effects and costs, with a time horizon of 12 weeks and 35 years, respectively. Cost and probability input data were primarily obtained from a retrospective real-world study conducted in five tertiary hospitals. Propensity score matching was adopted to overcome retrospective bias. Other parameters were extracted from literature as well as advice from clinical experts. Univariate and probabilistic sensitivity analyses were conducted.Results: In the first chemotherapy model, PEG-rhG-CSF was associated with fewer episodes of febrile neutropenia (FN) (N = 19 per 1000 patients treated), infections (N = 24 per 1000 patients treated) and deaths (N = 2 per 1000 patients treated), but higher costs (¥36 more per patient treated). The post-chemotherapy model indicated that PEG-rhG-CSF led to higher gains in quality-adjusted life years (QALYs) (11.695 versus 11.516) in comparison to rhG-CSF. Sensitivity analysis showed that the cost of PEG-rhG-CSF had the greatest impact on the incremental costs, and incremental QALYs were very sensitive to the risk of RDI Conclusion: According to this economic evaluation based on real-world data, PEG-rhG-CSF may be considered as a more cost-effective strategy relative to rhG-CSF for stage II-IV breast cancer patients in central China. However, to reflect a national perspective, further evidence is needed using data from larger-scale studies.

Additional file 1.

Additional file 1: Figure S1. Scatterplot of polymyxin B AUCss,24h versus dosage. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state. Figure S2. Scatterplot of polymyxin B AUCss,24h (a) and C0h (b) stratified for different stages of acute kidney injury. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration. Figure S3. Kaplan-Meier estimates of survival to 30 days after administration of polymyxin B. Stratified by AUCss,24h (a) and C0h (b). AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration.